%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Tom L. Schmidt, Nicholas H. Barton, Gordana Rašić, Andrew P. Turley, Brian L. Montgomery, Inaki Iturbe-Ormaetxe, Peter E. Cook, Peter A. Ryan, Scott A. Ritchie, Ary A. Hoffmann, Scott L. O’Neill, Michael Turelli
Local introduction and heterogeneous spatial spread of dengue-suppressing Wolbachia through an urban population of Aedes aegypti
www.ploscompbiol.org
www.ploscompbiol.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 14 0 R/Contents 15 0 R/TrimBox[0 0 612 792]>>
endobj
14 0 obj
[16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R]
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref001)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref002)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref003)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref004)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref005)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref006)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref007)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref008)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref009)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref010)>>
endobj
26 0 obj
<>/Border[0 0 0]/A 39 0 R>>
endobj
39 0 obj
<>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref011)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref012)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref013)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref014)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref011)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref014)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref015)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref016)>>
endobj
35 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref017)>>
endobj
36 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref018)>>
endobj
37 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref019)>>
endobj
38 0 obj
<>/Border[0 0 0]/A 40 0 R>>
endobj
40 0 obj
<>
endobj
15 0 obj
[41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R]
endobj
41 0 obj
<>stream
q
0.955 g
0 w
199.9998 713.9999 m
575.9997 713.9999 l
575.9997 494.0005 l
199.9998 494.0005 l
f*
0.83 0.64 0.02 0 k
481.6063 432.9071 m
486.3685 432.9071 l
h
f*
350.1921 406.9417 m
354.9543 406.9417 l
h
f*
353.4803 380.9197 m
358.2425 380.9197 l
h
f*
360.5102 380.9197 m
365.2724 380.9197 l
h
f*
246.2173 315.9496 m
250.9795 315.9496 l
h
f*
253.2472 315.9496 m
258.0094 315.9496 l
h
f*
260.2205 315.9496 m
264.9827 315.9496 l
h
f*
267.2504 315.9496 m
272.0126 315.9496 l
h
f*
274.2803 315.9496 m
279.0425 315.9496 l
h
f*
281.2535 315.9496 m
290.778 315.9496 l
h
f*
274.337 289.9276 m
446.7402 289.9276 l
h
f*
501.9024 250.9228 m
511.4268 250.9228 l
h
f*
513.6945 250.9228 m
523.1622 250.9228 l
h
f*
408.3591 211.9181 m
417.8835 211.9181 l
h
f*
420.1512 211.9181 m
429.6756 211.9181 l
h
f*
450.7087 185.8961 m
460.2331 185.8961 l
h
f*
553.7197 146.948 m
563.2441 146.948 l
h
f*
472.3087 133.9087 m
481.7764 133.9087 l
h
f*
360.6803 94.9039 m
370.2047 94.9039 l
h
f*
372.4724 94.9039 m
381.9969 94.9039 l
h
f*
384.2646 94.9039 m
393.7323 94.9039 l
h
f*
396 94.9039 m
405.5244 94.9039 l
h
f*
0 g
1 j
1 J
10 0 0 10 209.9905 696.9826 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Zika,)Tj
2.245 0 Td
(and)Tj
1.7291 0 Td
(other)Tj
2.3471 0 Td
(arboviruses)Tj
4.8075 0 Td
(that)Tj
1.7801 0 Td
(cause)Tj
2.3868 0 Td
(human)Tj
3.0784 0 Td
(disease.)Tj
/F8 1 Tf
3.2428 0 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
4.4561 0 Td
(invade)Tj
2.8799 0 Td
(populations)Tj
4.9493 0 Td
(by)Tj
-33.9021 -1.2982 Td
(causing)Tj
3.2484 0 Td
(cytoplasmic)Tj
4.972 0 Td
(incompatibility,)Tj
6.5706 0 Td
(a)Tj
0.652 0 Td
(phenomenon)Tj
5.5899 0 Td
(whereby)Tj
3.6113 0 Td
(embryos)Tj
3.668 0 Td
(from)Tj
2.2054 0 Td
(crosses)Tj
-30.5176 -1.2983 Td
(between)Tj
3.5319 0 Td
(infected)Tj
3.4186 0 Td
(males)Tj
2.5058 0 Td
(and)Tj
1.7291 0 Td
(uninfected)Tj
4.4957 0 Td
(females)Tj
3.2145 0 Td
(fail)Tj
1.457 0 Td
(to)Tj
1.0261 0 Td
(hatch.)Tj
2.6532 0 Td
(While)Tj
/F8 1 Tf
2.6532 0 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
4.4561 0 Td
(have)Tj
2.0636 0 Td
(been)Tj
-33.2048 -1.3039 Td
(shown)Tj
2.8516 0 Td
(to)Tj
1.0205 0 Td
(successfully)Tj
4.8642 0 Td
(invade)Tj
2.88 0 Td
(and)Tj
1.7291 0 Td
(remain)Tj
3.0841 0 Td
(established)Tj
4.5977 0 Td
(in)Tj
1.0318 0 Td
(isolated)Tj
/F8 1 Tf
3.2882 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.491 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
2.982 0 Td
(populations,)Tj
-29.8202 -1.2983 Td
(outward)Tj
3.5716 0 Td
(spread)Tj
2.8516 0 Td
(from)Tj
2.211 0 Td
(urban)Tj
2.6079 0 Td
(release)Tj
2.9026 0 Td
(zones)Tj
2.4718 0 Td
(has)Tj
1.5421 0 Td
(not)Tj
1.576 0 Td
(been)Tj
2.1203 0 Td
(previously)Tj
4.3483 0 Td
(documented.)Tj
5.4766 0 Td
(This)Tj
1.9842 0 Td
(is)Tj
0.8504 0 Td
(an)Tj
-34.5144 -1.2982 Td
(important)Tj
4.2802 0 Td
(step)Tj
1.8199 0 Td
(in)Tj
1.0374 0 Td
(demonstrating)Tj
6.0888 0 Td
(that)Tj
/F8 1 Tf
1.7802 0 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
4.4617 0 Td
(can)Tj
1.6214 0 Td
(be)Tj
1.1508 0 Td
(used)Tj
2.0636 0 Td
(to)Tj
1.0262 0 Td
(combat)Tj
3.2088 0 Td
(mosquito-borne)Tj
-28.539 -1.3039 Td
(infectious)Tj
4.1328 0 Td
(disease)Tj
3.0161 0 Td
(in)Tj
1.0375 0 Td
(cities.)Tj
2.4831 0 Td
(Here)Tj
2.2053 0 Td
(we)Tj
1.3323 0 Td
(describe)Tj
/F8 1 Tf
3.5206 0 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
4.4617 0 Td
(spread)Tj
2.8517 0 Td
(from)Tj
2.2053 0 Td
(2)Tj
0.6973 0 Td
(introduction)Tj
5.3121 0 Td
(areas)Tj
-33.2558 -1.2983 Td
(within)Tj
2.8119 0 Td
(Cairns)Tj
2.8686 0 Td
(in)Tj
1.0318 0 Td
(northeastern)Tj
5.3348 0 Td
(Australia)Tj
3.8438 0 Td
(at)Tj
0.9524 0 Td
(a)Tj
0.652 0 Td
(rate)Tj
1.7518 0 Td
(of)Tj
1.0148 0 Td
(about)Tj
2.4944 0 Td
(100200)Tj
3.5887 0 Td
(meters)Tj
2.9196 0 Td
(per)Tj
1.5307 0 Td
(year.)Tj
2.126 0 Td
(Spread)Tj
-32.9213 -1.2983 Td
(occurs)Tj
2.8346 0 Td
(only)Tj
1.9785 0 Td
(when)Tj
2.4038 0 Td
(introduction)Tj
5.3121 0 Td
(areas)Tj
2.245 0 Td
(are)Tj
1.4457 0 Td
(sufficiently)Tj
4.6148 0 Td
(large.)Tj
2.3867 0 Td
(The)Tj
1.7802 0 Td
(slow)Tj
2.0182 0 Td
(rates)Tj
2.109 0 Td
(of)Tj
1.0148 0 Td
(observed)Tj
-30.1434 -1.2982 Td
(spread)Tj
2.8573 0 Td
(are)Tj
1.4456 0 Td
(broadly)Tj
3.2712 0 Td
(consistent)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(mathematical)Tj
5.6465 0 Td
(predictions)Tj
4.7282 0 Td
(based)Tj
2.4775 0 Td
(on)Tj
1.2755 0 Td
(estimated)Tj
/F8 1 Tf
4.0706 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
-32.0256 -1.304 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
2.9876 0 Td
(dispersal)Tj
3.7304 0 Td
(distances,)Tj
/F8 1 Tf
4.0876 0 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
4.4617 0 Td
(dynamics,)Tj
4.2802 0 Td
(and)Tj
1.7292 0 Td
(effects)Tj
2.7269 0 Td
(seen)Tj
1.9729 0 Td
(in)Tj
1.0375 0 Td
(isolated)Tj
3.2881 0 Td
(populations.)Tj
-30.3021 -1.2982 Td
(Spread)Tj
2.965 0 Td
(is)Tj
0.8447 0 Td
(uneven)Tj
3.1464 0 Td
(and)Tj
1.7235 0 Td
(likely)Tj
2.3527 0 Td
(depends)Tj
3.549 0 Td
(on)Tj
1.2699 0 Td
(local)Tj
2.0749 0 Td
(characteristics)Tj
5.9017 0 Td
(\(e.g.,)Tj
2.1203 0 Td
(barriers\))Tj
3.6624 0 Td
(that)Tj
1.7744 0 Td
(affect)Tj
2.3755 0 Td
(mos-)Tj
-33.7604 -1.2983 Td
(quito)Tj
2.33 0 Td
(density)Tj
3.1011 0 Td
(and)Tj
1.7291 0 Td
(dispersal.)Tj
3.9515 0 Td
(Our)Tj
1.8652 0 Td
(data)Tj
1.9162 0 Td
(indicate)Tj
3.4129 0 Td
(that)Tj
/F8 1 Tf
1.7745 0 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
4.4617 0 Td
(can)Tj
1.627 0 Td
(be)Tj
1.1452 0 Td
(introduced)Tj
4.6431 0 Td
(locally)Tj
2.778 0 Td
(in)Tj
-34.7355 -1.3039 Td
(large)Tj
2.1599 0 Td
(cities,)Tj
2.4888 0 Td
(remain)Tj
3.0841 0 Td
(established)Tj
4.5978 0 Td
(where)Tj
2.6475 0 Td
(released,)Tj
3.6567 0 Td
(and)Tj
1.7291 0 Td
(slowly)Tj
2.7213 0 Td
(spread)Tj
2.8516 0 Td
(from)Tj
2.2053 0 Td
(release)Tj
2.9027 0 Td
(areas.)Tj
-31.0448 -1.2983 Td
(These)Tj
2.5681 0 Td
(dynamics)Tj
4.0535 0 Td
(indicate)Tj
3.4129 0 Td
(that)Tj
1.7802 0 Td
(high)Tj
/F8 1 Tf
2.0069 0 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
4.456 0 Td
(infection)Tj
3.7928 0 Td
(frequencies)Tj
4.7848 0 Td
(can)Tj
1.6271 0 Td
(be)Tj
1.1508 0 Td
(established)Tj
-29.6331 -1.2982 Td
(gradually)Tj
3.9287 0 Td
(across)Tj
2.6759 0 Td
(large)Tj
2.16 0 Td
(urban)Tj
2.6079 0 Td
(areas)Tj
2.245 0 Td
(through)Tj
3.4469 0 Td
(local)Tj
2.075 0 Td
(releases.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 450.9921 cm
BT
/F3 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 433.9842 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Dengue)Tj
3.3448 0 Td
(fever)Tj
2.177 0 Td
(is)Tj
0.8504 0 Td
(the)Tj
1.4683 0 Td
(most)Tj
2.2054 0 Td
(common)Tj
3.8494 0 Td
(arboviral)Tj
3.8097 0 Td
(disease)Tj
3.0161 0 Td
(affecting)Tj
3.6566 0 Td
(humans)Tj
3.4413 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.5987 0 Td
(Over)Tj
2.2167 0 Td
(2,500,000,000)Tj
-31.6344 -1.2982 Td
(people)Tj
2.8516 0 Td
(live)Tj
1.6157 0 Td
(in)Tj
1.0318 0 Td
(dengue-afflicted)Tj
6.6841 0 Td
(regions,)Tj
3.3902 0 Td
(and)Tj
1.7291 0 Td
(dengue)Tj
3.1351 0 Td
(incidence)Tj
4.0762 0 Td
(is)Tj
0.8447 0 Td
(increasing)Tj
4.3313 0 Td
(at)Tj
0.9525 0 Td
(an)Tj
1.2019 0 Td
(alarming)Tj
3.804 0 Td
(rate)Tj
-35.6482 -1.2983 Td
(in)Tj
1.0318 0 Td
(tropical)Tj
3.2881 0 Td
(and)Tj
1.7291 0 Td
(subtropical)Tj
4.6829 0 Td
(countries)Tj
3.9458 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
1.5987 0 Td
(A)Tj
0.9071 0 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(other)Tj
2.3471 0 Td
(arboviruses)Tj
4.8075 0 Td
(also)Tj
1.7632 0 Td
(represent)Tj
3.9628 0 Td
(emerg-)Tj
-34.4974 -1.3039 Td
(ing)Tj
1.5023 0 Td
(disease)Tj
3.016 0 Td
(risks,)Tj
2.3018 0 Td
(including)Tj
4.0421 0 Td
(chikungunya)Tj
5.4425 0 Td
(and)Tj
1.7292 0 Td
(Zika,)Tj
2.245 0 Td
(the)Tj
1.4683 0 Td
(latter)Tj
2.2904 0 Td
(being)Tj
2.4321 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.652 0 Td
(recent)Tj
-33.3749 -1.2983 Td
(explosive)Tj
3.8834 0 Td
(epidemic)Tj
3.8891 0 Td
(in)Tj
1.0375 0 Td
(South)Tj
2.5568 0 Td
(America)Tj
3.6397 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(].)Tj
2.3017 0 Td
(The)Tj
1.7858 0 Td
(main)Tj
2.2904 0 Td
(approach)Tj
3.9515 0 Td
(to)Tj
1.0261 0 Td
(controlling)Tj
4.6488 0 Td
(these)Tj
2.2507 0 Td
(diseases)Tj
-33.2615 -1.2982 Td
(has)Tj
1.542 0 Td
(been)Tj
2.1203 0 Td
(suppression)Tj
4.9833 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(principal)Tj
3.8154 0 Td
(mosquito)Tj
4.0138 0 Td
(vector,)Tj
/F8 1 Tf
2.9254 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.491 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
(,)Tj
3.2088 0 Td
(either)Tj
2.5341 0 Td
(through)Tj
3.4413 0 Td
(source)Tj
-32.5585 -1.3039 Td
(reduction)Tj
4.1158 0 Td
(or)Tj
1.0942 0 Td
(insecticide-based)Tj
7.0582 0 Td
(control)Tj
3.1181 0 Td
(programs.)Tj
4.2916 0 Td
(Given)Tj
2.6306 0 Td
(the)Tj
1.4683 0 Td
(increasing)Tj
4.3313 0 Td
(incidence)Tj
4.0762 0 Td
(of)Tj
/F8 1 Tf
1.0148 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
-33.1991 -1.2983 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
(-associated)Tj
7.37 0 Td
(human)Tj
3.0784 0 Td
(disease,)Tj
3.2428 0 Td
(it)Tj
0.788 0 Td
(is)Tj
0.8447 0 Td
(clear)Tj
2.1203 0 Td
(that)Tj
1.7802 0 Td
(current)Tj
3.1861 0 Td
(control)Tj
3.1181 0 Td
(measures)Tj
3.9401 0 Td
(are)Tj
1.4514 0 Td
(insufficient.)Tj
4.9549 0 Td
(In)Tj
-35.875 -1.2983 Td
(response)Tj
3.7303 0 Td
(to)Tj
1.0262 0 Td
(this)Tj
1.6724 0 Td
(problem,)Tj
3.8381 0 Td
(a)Tj
0.6576 0 Td
(number)Tj
3.4129 0 Td
(of)Tj
1.0148 0 Td
(new)Tj
1.8765 0 Td
(control)Tj
3.1238 0 Td
(approaches)Tj
4.7395 0 Td
(are)Tj
1.4456 0 Td
(currently)Tj
3.8835 0 Td
(being)Tj
2.4321 0 Td
(developed)Tj
-32.8533 -1.2982 Td
(and)Tj
1.7291 0 Td
(tested)Tj
2.5511 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(].)Tj
-3.084 -1.304 Td
(In)Tj
1.1111 0 Td
(contrast)Tj
3.464 0 Td
(to)Tj
1.0261 0 Td
(control)Tj
3.1181 0 Td
(efforts)Tj
2.7552 0 Td
(that)Tj
1.7802 0 Td
(require)Tj
3.1124 0 Td
(repeated)Tj
3.6397 0 Td
(population)Tj
4.5921 0 Td
(suppression,)Tj
5.2043 0 Td
(the)Tj
1.4684 0 Td
(Eliminate)Tj
-32.4678 -1.2982 Td
(Dengue)Tj
3.3448 0 Td
(Program)Tj
3.7474 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(http://www.eliminatedengue.c)Tj
12.4383 0 Td
(om/program)Tj
0 g
(\))Tj
5.6976 0 Td
(aims)Tj
2.1033 0 Td
(to)Tj
1.0262 0 Td
(modify)Tj
3.084 0 Td
(populations)Tj
-31.4416 -1.2983 Td
(using)Tj
2.3867 0 Td
(long-lasting)Tj
4.9606 0 Td
(local)Tj
2.075 0 Td
(introductions)Tj
5.6749 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(dengue-inhibiting)Tj
/F8 1 Tf
7.4494 0 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
4.4617 0 Td
(into)Tj
1.8426 0 Td
(naturally)Tj
3.7813 0 Td
(unin-)Tj
-34.2989 -1.3039 Td
(fected)Tj
2.6021 0 Td
(populations)Tj
4.9493 0 Td
(of)Tj
/F8 1 Tf
1.0148 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.4853 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
(.)Tj
3.2088 0 Td
(The)Tj
1.7859 0 Td
(strain,)Tj
/F8 1 Tf
2.7212 0 Td
[()]TJ
/F9 1 Tf
(Mel,)Tj
2.6702 0 Td
(was)Tj
1.6951 0 Td
(transferred)Tj
4.6375 0 Td
(from)Tj
/F8 1 Tf
2.2053 0 Td
[()-4()20()7(\r)-3()11()10()18()4()4()]TJ
4.5071 0 Td
[()6()15()4()16()6()2()2( )]TJ
-33.4826 -1.2983 Td
[(\r)9()11()2()]TJ
/F9 1 Tf
1.5987 0 Td
(into)Tj
1.8425 0 Td
(laboratory-raised)Tj
/F8 1 Tf
7.0866 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.491 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
(,)Tj
3.2088 0 Td
(who)Tj
1.9389 0 Td
(inherit)Tj
2.9253 0 Td
(the)Tj
1.4683 0 Td
(infection)Tj
3.7928 0 Td
(maternally)Tj
4.4957 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(].)Tj
3.2541 0 Td
(Following)Tj
-33.1027 -1.2982 Td
(introgression)Tj
5.5161 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(infection)Tj
3.7927 0 Td
(into)Tj
1.8425 0 Td
(a)Tj
0.652 0 Td
(native)Tj
2.6475 0 Td
(genetic)Tj
3.0671 0 Td
(background,)Tj
/F8 1 Tf
5.2554 0 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
(-infected)Tj
8.0106 0 Td
(mosqui-)Tj
-33.2671 -1.3039 Td
(toes)Tj
1.8084 0 Td
(are)Tj
1.4514 0 Td
(released)Tj
3.4299 0 Td
(into)Tj
1.8368 0 Td
(the)Tj
1.474 0 Td
(field)Tj
1.9729 0 Td
(to)Tj
1.0205 0 Td
(mate)Tj
2.1997 0 Td
(with)Tj
1.9955 0 Td
(wild)Tj
1.9446 0 Td
(uninfected)Tj
4.4957 0 Td
(mosquitoes,)Tj
5.023 0 Td
(and)Tj
/F8 1 Tf
1.7348 0 Td
[()]TJ
/F9 1 Tf
(Mel)Tj
2.4434 0 Td
(frequency)Tj
-32.8306 -1.2983 Td
(increases)Tj
3.8324 0 Td
(through)Tj
3.4469 0 Td
(cytoplasmic)Tj
4.9719 0 Td
(incompatibility)Tj
6.3382 0 Td
(\(CI\))Tj
1.9049 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(].)Tj
3.2542 0 Td
(CI)Tj
1.2245 0 Td
(describes)Tj
3.8835 0 Td
(the)Tj
1.4683 0 Td
(fact)Tj
1.6668 0 Td
(that)Tj
1.7801 0 Td
(unin-)Tj
-33.7717 -1.2983 Td
(fected)Tj
2.6021 0 Td
(females)Tj
3.2145 0 Td
(mated)Tj
2.7269 0 Td
(with)Tj
/F8 1 Tf
1.9956 0 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
(-infected)Tj
8.0107 0 Td
(males)Tj
2.5058 0 Td
(produce)Tj
3.5149 0 Td
(inviable)Tj
3.3675 0 Td
(embryos.)Tj
3.8892 0 Td
(In)Tj
/F8 1 Tf
1.1111 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.491 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
(,)Tj
-34.4293 -1.3039 Td
(this)Tj
1.6724 0 Td
(is)Tj
0.8504 0 Td
(believed)Tj
3.4922 0 Td
(to)Tj
1.0262 0 Td
(occur)Tj
2.4718 0 Td
(in)Tj
1.0374 0 Td
(100%)Tj
2.4038 0 Td
(of)Tj
1.0148 0 Td
(these)Tj
2.2507 0 Td
(incompatible)Tj
5.4822 0 Td
(crosses)Tj
3.0273 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(].)Tj
2.075 0 Td
(In)Tj
1.1112 0 Td
(contrast,)Tj
3.685 0 Td
(infected)Tj
-31.6004 -1.2983 Td
(females)Tj
3.2144 0 Td
(can)Tj
1.6271 0 Td
(mate)Tj
2.194 0 Td
(with)Tj
1.9956 0 Td
(either)Tj
2.5341 0 Td
(infected)Tj
3.4186 0 Td
(or)Tj
1.0998 0 Td
(uninfected)Tj
4.4957 0 Td
(males)Tj
2.5059 0 Td
(and)Tj
1.7291 0 Td
(produce)Tj
3.5206 0 Td
(almost)Tj
2.8856 0 Td
(100%)Tj
2.4038 0 Td
(infected)Tj
-33.6243 -1.2982 Td
(progeny.)Tj
3.7303 0 Td
(CI)Tj
1.2246 0 Td
(greatly)Tj
2.914 0 Td
(reduces)Tj
3.2768 0 Td
(the)Tj
1.4683 0 Td
(relative)Tj
3.1408 0 Td
(fitness)Tj
2.7666 0 Td
(of)Tj
1.0148 0 Td
(uninfected)Tj
4.4957 0 Td
(females)Tj
3.2202 0 Td
(when)Tj
2.4037 0 Td
(infected)Tj
3.4186 0 Td
(males)Tj
2.5058 0 Td
(are)Tj
-35.5802 -1.2983 Td
(common)Tj
3.8437 0 Td
(and)Tj
1.7291 0 Td
(drives)Tj
2.6249 0 Td
(rapid)Tj
2.3414 0 Td
(establishment)Tj
5.7316 0 Td
(of)Tj
/F8 1 Tf
1.0148 0 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
4.4617 0 Td
(in)Tj
1.0375 0 Td
(isolated)Tj
3.2825 0 Td
(mosquito)Tj
4.0138 0 Td
(populations)Tj
4.9493 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(],)Tj
-35.0303 -1.3039 Td
(given)Tj
2.3754 0 Td
(that)Tj
1.7801 0 Td
(there)Tj
2.2677 0 Td
(is)Tj
0.8447 0 Td
(no)Tj
1.2756 0 Td
(mating)Tj
3.0557 0 Td
(bias)Tj
1.7859 0 Td
(against)Tj
/F8 1 Tf
3.0273 0 Td
[()]TJ
/F9 1 Tf
(Mel-infected)Tj
/F8 1 Tf
5.9981 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.491 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
2.9877 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
-25.693 -1.2983 Td
(Although)Tj
/F8 1 Tf
4.0081 0 Td
[()]TJ
/F9 1 Tf
(Mel-infected)Tj
5.9924 0 Td
(females)Tj
3.2202 0 Td
(receive)Tj
3.0047 0 Td
(a)Tj
0.6519 0 Td
(frequency-dependent)Tj
8.7817 0 Td
(relative)Tj
3.1351 0 Td
(fitness)Tj
2.7666 0 Td
(advantage)Tj
-32.7569 -1.2982 Td
(from)Tj
2.2053 0 Td
(CI,)Tj
1.4457 0 Td
(they)Tj
1.9275 0 Td
(also)Tj
1.7688 0 Td
(suffer)Tj
2.4775 0 Td
(from)Tj
2.2053 0 Td
(frequency-independent)Tj
9.5924 0 Td
(fitness)Tj
2.7666 0 Td
(costs,)Tj
2.3981 0 Td
(including)Tj
4.0422 0 Td
(decreases)Tj
3.9684 0 Td
(in)Tj
-34.7978 -1.304 Td
(fecundity)Tj
3.9798 0 Td
(and)Tj
1.7291 0 Td
(larval)Tj
2.4038 0 Td
(competitive)Tj
4.9209 0 Td
(ability)Tj
2.6929 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(].)Tj
5.6069 0 Td
(Thus,)Tj
2.4774 0 Td
(CI)Tj
1.2189 0 Td
(does)Tj
2.0409 0 Td
(not)Tj
1.5761 0 Td
(produce)Tj
3.5149 0 Td
(a)Tj
0.6577 0 Td
(net)Tj
1.4853 0 Td
(fitness)Tj
-34.3046 -1.2982 Td
(advantage)Tj
4.2406 0 Td
(while)Tj
/F8 1 Tf
2.364 0 Td
[()]TJ
/F9 1 Tf
(Mel)Tj
2.4492 0 Td
(is)Tj
0.8447 0 Td
(rare,)Tj
2.0466 0 Td
(resulting)Tj
3.7303 0 Td
(in)Tj
1.0375 0 Td
(dynamics)Tj
4.0535 0 Td
(analogous)Tj
4.252 0 Td
(to)Tj
1.0261 0 Td
(those)Tj
2.3357 0 Td
(produced)Tj
4.0479 0 Td
(by)Tj
1.1792 0 Td
(an)Tj
1.2019 0 Td
(Allee)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 129.8268 23.6976 re
W* n
q
129.7701 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 371.9622 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Spread)Tj
3.3874 0 Td
(of)Tj
1.0417 0 Td
(dengue-suppr)Tj
6.0591 0 Td
(essing)Tj
/F7 1 Tf
3.0544 0 Td
(Wolbachi)Tj
4.0394 0 Td
(a)Tj
/F0 1 Tf
0.7653 0 Td
(in)Tj
/F7 1 Tf
0.978 0 Td
(Aedes)Tj
3.0118 0 Td
(aegypti)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
90.1417 34.9228 m
243.8362 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Biology)Tj
3.437 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.pb)Tj
5.1236 0 Td
(io.2001894)Tj
0 g
5.8536 0 Td
(May)Tj
2.0835 0 Td
(30,)Tj
1.5874 0 Td
(2017)Tj
34.4908 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(28)Tj
/F12 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(National)Tj
3.2386 0 Td
(Health)Tj
2.5724 0 Td
(and)Tj
1.5874 0 Td
(Medical)Tj
3.0969 0 Td
(Research)Tj
3.6992 0 Td
(Council)Tj
-14.1945 -1.3748 Td
(\(grant)Tj
2.459 0 Td
(number)Tj
3.1252 0 Td
(104469)Tj
2.8347 0 Td
(8\).)Tj
1.226 0 Td
(NHMRC)Tj
3.2599 0 Td
(to)Tj
0.9496 0 Td
(SAR.)Tj
2.0835 0 Td
(The)Tj
-15.9379 -1.3749 Td
(funder)Tj
2.622 0 Td
(had)Tj
1.5874 0 Td
(no)Tj
1.1693 0 Td
(role)Tj
1.6158 0 Td
(in)Tj
0.8858 0 Td
(study)Tj
2.2678 0 Td
(design,)Tj
2.8984 0 Td
(data)Tj
1.7929 0 Td
(collection)Tj
-14.8394 -1.3748 Td
(and)Tj
1.5874 0 Td
(analysis,)Tj
3.4087 0 Td
(decision)Tj
3.2953 0 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1464 0 Td
(or)Tj
0.9993 0 Td
(preparation)Tj
4.4362 0 Td
(of)Tj
-17.8229 -1.3748 Td
(the)Tj
1.3677 0 Td
(manuscript.)Tj
4.6417 0 Td
(National)Tj
3.2387 0 Td
(Health)Tj
2.5724 0 Td
(and)Tj
1.5874 0 Td
(Medical)Tj
-13.4079 -1.3748 Td
(Research)Tj
3.6992 0 Td
(Council.)Tj
3.1961 0 Td
(NHMRC)Tj
3.2598 0 Td
(program)Tj
3.43 0 Td
(and)Tj
1.5874 0 Td
(fellowship)Tj
-15.1725 -1.3748 Td
(funding)Tj
3.033 0 Td
(to)Tj
0.9497 0 Td
(AAH.)Tj
2.0834 0 Td
(The)Tj
1.5875 0 Td
(funder)Tj
2.6291 0 Td
(had)Tj
1.5874 0 Td
(no)Tj
1.1622 0 Td
(role)Tj
1.6158 0 Td
(in)Tj
0.8858 0 Td
(study)Tj
-15.5339 -1.3748 Td
(design,)Tj
2.8984 0 Td
(data)Tj
1.7929 0 Td
(collection)Tj
3.7418 0 Td
(and)Tj
1.5874 0 Td
(analysis,)Tj
3.4087 0 Td
(decision)Tj
3.2953 0 Td
(to)Tj
-16.7245 -1.3748 Td
(publish,)Tj
3.1464 0 Td
(or)Tj
0.9993 0 Td
(preparation)Tj
4.4433 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3677 0 Td
(manuscript.)Tj
4.6347 0 Td
(NIH)Tj
-15.541 -1.3748 Td
(\(grant)Tj
2.459 0 Td
(number)Tj
3.1252 0 Td
(R01)Tj
1.7505 0 Td
(GM10432)Tj
3.7063 0 Td
(5\).)Tj
1.226 0 Td
(NIH)Tj
1.6512 0 Td
(funding)Tj
3.0331 0 Td
(to)Tj
-16.9513 -1.3749 Td
(MT)Tj
1.4456 0 Td
(and)Tj
1.5874 0 Td
(AAH.)Tj
2.0835 0 Td
(The)Tj
1.5874 0 Td
(funder)Tj
2.6292 0 Td
(had)Tj
1.5874 0 Td
(no)Tj
1.1622 0 Td
(role)Tj
1.6158 0 Td
(in)Tj
0.8858 0 Td
(study)Tj
-14.5843 -1.3748 Td
(design,)Tj
2.8984 0 Td
(data)Tj
1.7929 0 Td
(collection)Tj
3.7418 0 Td
(and)Tj
1.5874 0 Td
(analysis,)Tj
3.4087 0 Td
(decision)Tj
3.2953 0 Td
(to)Tj
-16.7245 -1.3748 Td
(publish,)Tj
3.1464 0 Td
(or)Tj
0.9993 0 Td
(preparation)Tj
4.4433 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3677 0 Td
(manuscript.)Tj
/F11 1 Tf
-10.9063 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F12 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3748 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
3.3874 0 Td
(exist.)Tj
/F11 1 Tf
-10.3394 -2.126 Td
(Abbreviati)Tj
3.9118 0 Td
(ons:)Tj
/F12 1 Tf
1.8425 0 Td
(CI,)Tj
1.226 0 Td
(cytoplasmic)Tj
4.6701 0 Td
(incompatibi)Tj
4.3229 0 Td
(lity;)Tj
1.5095 0 Td
(D1,)Tj
-17.4828 -1.3748 Td
(first)Tj
1.6511 0 Td
(dry)Tj
1.4245 0 Td
(season;)Tj
3.0756 0 Td
(D2,)Tj
1.5024 0 Td
(second)Tj
2.9055 0 Td
(dry)Tj
1.4244 0 Td
(season;)Tj
3.0756 0 Td
(EHW,)Tj
-15.0591 -1.3748 Td
(Edge)Tj
2.0622 0 Td
(Hill/Whitf)Tj
3.4016 0 Td
(ield;)Tj
1.7291 0 Td
(MLE,)Tj
2.1402 0 Td
(maximum)Tj
3.9969 0 Td
(likelihood)Tj
-13.33 -1.3748 Td
(estimate;)Tj
3.5858 0 Td
(PP,)Tj
1.4953 0 Td
(Parramatta)Tj
4.3087 0 Td
(Park;)Tj
2.126 0 Td
(W1,)Tj
1.722 0 Td
(first)Tj
1.6512 0 Td
(wet)Tj
-14.889 -1.3749 Td
(season;)Tj
3.0756 0 Td
(W2,)Tj
1.722 0 Td
(second)Tj
2.9056 0 Td
(wet)Tj
1.5378 0 Td
(season;)Tj
3.0756 0 Td
(WC,)Tj
1.7787 0 Td
(Westcou)Tj
ET
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
endstream
endobj
52 0 obj
<>stream
endstream
endobj
53 0 obj
<>stream
endstream
endobj
54 0 obj
<>stream
endstream
endobj
55 0 obj
<>stream
endstream
endobj
56 0 obj
<>stream
endstream
endobj
57 0 obj
<>stream
endstream
endobj
58 0 obj
<>stream
endstream
endobj
59 0 obj
<>stream
endstream
endobj
60 0 obj
<>stream
endstream
endobj
61 0 obj
<>stream
BT
17.3623 56.4665 Td
(rt.)Tj
ET
Q
endstream
endobj
62 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 66 0 R/Contents 67 0 R/TrimBox[0 0 612 792]>>
endobj
66 0 obj
[68 0 R 69 0 R 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R 83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R 100 0 R 101 0 R 102 0 R 103 0 R 104 0 R 105 0 R 106 0 R 107 0 R 108 0 R 109 0 R 110 0 R 111 0 R 112 0 R 113 0 R 114 0 R 115 0 R]
endobj
68 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref020)>>
endobj
69 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref021)>>
endobj
70 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref022)>>
endobj
71 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref023)>>
endobj
72 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref024)>>
endobj
73 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref025)>>
endobj
74 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref026)>>
endobj
75 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref027)>>
endobj
76 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref023)>>
endobj
77 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref028)>>
endobj
78 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref029)>>
endobj
79 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref030)>>
endobj
80 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref031)>>
endobj
81 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref014)>>
endobj
82 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref019)>>
endobj
83 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref032)>>
endobj
84 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref031)>>
endobj
85 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref020)>>
endobj
86 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref029)>>
endobj
87 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref011)>>
endobj
88 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref014)>>
endobj
89 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref031)>>
endobj
90 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref014)>>
endobj
91 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref018)>>
endobj
92 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref033)>>
endobj
93 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref014)>>
endobj
94 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref020)>>
endobj
95 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref034)>>
endobj
96 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref035)>>
endobj
97 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref036)>>
endobj
98 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref037)>>
endobj
99 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref034)>>
endobj
100 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref038)>>
endobj
101 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref039)>>
endobj
102 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref040)>>
endobj
103 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref041)>>
endobj
104 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref042)>>
endobj
105 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref031)>>
endobj
106 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref042)>>
endobj
107 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref043)>>
endobj
108 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref044)>>
endobj
109 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref045)>>
endobj
110 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref046)>>
endobj
111 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref047)>>
endobj
112 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref048)>>
endobj
113 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref020)>>
endobj
114 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref031)>>
endobj
115 0 obj
<>/Border[0 0 0]/A 116 0 R>>
endobj
116 0 obj
<>
endobj
67 0 obj
[117 0 R 118 0 R 119 0 R 120 0 R 121 0 R 122 0 R 123 0 R 124 0 R 125 0 R 126 0 R 127 0 R 128 0 R 129 0 R 130 0 R 131 0 R 132 0 R 133 0 R 134 0 R 135 0 R 136 0 R 137 0 R 138 0 R 139 0 R 140 0 R 141 0 R 142 0 R 143 0 R 144 0 R 145 0 R 146 0 R 147 0 R 148 0 R 149 0 R 150 0 R]
endobj
117 0 obj
<>stream
q
0.83 0.64 0.02 0 k
269.8583 706.337 m
279.3827 706.337 l
h
f*
281.6504 706.337 m
291.1748 706.337 l
h
f*
521.5181 693.2976 m
531.0425 693.2976 l
h
f*
533.3102 693.2976 m
542.8346 693.2976 l
h
f*
545.0457 693.2976 m
554.5701 693.2976 l
h
f*
295.5402 641.1969 m
305.0646 641.1969 l
h
f*
307.3323 641.1969 m
316.8 641.1969 l
h
f*
319.0677 641.1969 m
328.5921 641.1969 l
h
f*
242.4756 628.1575 m
252 628.1575 l
h
f*
376.5543 615.1748 m
386.022 615.1748 l
h
f*
369.2976 602.1921 m
378.822 602.1921 l
h
f*
320.315 563.1874 m
329.8394 563.1874 l
h
f*
302.5134 550.148 m
312.0378 550.148 l
h
f*
541.8709 550.148 m
551.3386 550.148 l
h
f*
450.085 537.1654 m
459.5528 537.1654 l
h
f*
461.8205 537.1654 m
471.3449 537.1654 l
h
f*
419.5276 511.1433 m
428.9953 511.1433 l
h
f*
203.4142 445.7197 m
212.9386 445.7197 l
h
f*
215.1496 445.7197 m
224.674 445.7197 l
h
f*
522.4252 432.6803 m
531.8929 432.6803 l
h
f*
534.1606 432.6803 m
543.685 432.6803 l
h
f*
545.9528 432.6803 m
555.4205 432.6803 l
h
f*
203.4142 393.7323 m
212.9386 393.7323 l
h
f*
501.9024 393.7323 m
511.4268 393.7323 l
h
f*
370.0346 367.7102 m
379.5591 367.7102 l
h
f*
411.4205 328.7055 m
420.9449 328.7055 l
h
f*
376.1008 250.6961 m
385.6252 250.6961 l
h
f*
479.1685 224.7307 m
488.6929 224.7307 l
h
f*
490.9606 224.7307 m
500.4283 224.7307 l
h
f*
502.6961 224.7307 m
512.2205 224.7307 l
h
f*
246.5575 198.7087 m
256.0252 198.7087 l
h
f*
385.9087 185.726 m
395.3764 185.726 l
h
f*
397.6441 185.726 m
407.1685 185.726 l
h
f*
409.4362 185.726 m
418.9606 185.726 l
h
f*
421.1717 185.726 m
430.6961 185.726 l
h
f*
432.9638 185.726 m
442.4882 185.726 l
h
f*
444.6992 185.726 m
454.2236 185.726 l
h
f*
297.8079 172.6866 m
307.3323 172.6866 l
h
f*
309.6 172.6866 m
319.1244 172.6866 l
h
f*
321.3354 172.6866 m
330.8598 172.6866 l
h
f*
469.2472 172.6866 m
478.7717 172.6866 l
h
f*
445.4929 159.7039 m
455.0173 159.7039 l
h
f*
457.285 159.7039 m
466.7528 159.7039 l
h
f*
469.0205 159.7039 m
478.5449 159.7039 l
h
f*
480.8126 159.7039 m
490.337 159.7039 l
h
f*
543.1181 133.6819 m
552.6425 133.6819 l
h
f*
554.8535 133.6819 m
564.378 133.6819 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(effect)Tj
2.364 0 Td
(in)Tj
1.0375 0 Td
(ecology)Tj
3.2428 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(])Tj
3.0274 0 Td
(and)Tj
1.7348 0 Td
(by)Tj
1.1792 0 Td
(natural)Tj
3.0784 0 Td
(selection)Tj
3.719 0 Td
(on)Tj
1.2756 0 Td
(a)Tj
0.6577 0 Td
(locus)Tj
2.2847 0 Td
(\(or)Tj
1.4343 0 Td
(alternative)Tj
4.422 0 Td
(karyotypes\))Tj
4.8812 0 Td
(in)Tj
-34.3386 -1.3039 Td
(which)Tj
2.6475 0 Td
(heterozygotes)Tj
5.6976 0 Td
(are)Tj
1.4457 0 Td
(less)Tj
1.61 0 Td
(fit)Tj
1.0772 0 Td
(than)Tj
2.0296 0 Td
(either)Tj
2.5285 0 Td
(homozygotes)Tj
5.5048 0 Td
(\(i.e.,)Tj
1.9276 0 Td
(underdominance,)Tj
7.3416 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(]\).)Tj
-31.8101 -1.2982 Td
(The)Tj
1.7801 0 Td
(interaction)Tj
4.6091 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(frequency-dependent)Tj
8.776 0 Td
(advantage)Tj
4.2406 0 Td
(associated)Tj
4.2577 0 Td
(with)Tj
1.9955 0 Td
(CI)Tj
1.2246 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(frequency-)Tj
-32.5698 -1.2983 Td
(independent)Tj
5.2724 0 Td
(cost\(s\))Tj
2.8516 0 Td
(produces)Tj
3.8778 0 Td
(bistable)Tj
3.6566 0 Td
(dynamics)Tj
4.4504 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.6519 0 Td
(threshold)Tj
4.0139 0 Td
(frequency)Tj
4.1896 0 Td
(of)Tj
1.0148 0 Td
(infection)Tj
-31.9746 -1.3153 Td
(\(denoted)Tj
/F15 1 Tf
0 Tc
3.8324 0.0794 Td
(^)Tj
/F8 1 Tf
-0.017 -0.0794 Td
[()]TJ
/F9 1 Tf
-0.004 Tc
0.5272 0 Td
(\))Tj
0.5613 0 Td
(below)Tj
2.5908 0 Td
(which)Tj
2.6475 0 Td
(the)Tj
1.4684 0 Td
(infection)Tj
3.7927 0 Td
(will)Tj
1.6668 0 Td
(be)Tj
1.1452 0 Td
(locally)Tj
2.7779 0 Td
(eliminated)Tj
4.4787 0 Td
(and)Tj
1.7291 0 Td
(above)Tj
2.5455 0 Td
(which)Tj
2.6532 0 Td
(frequencies)Tj
-32.3997 -1.2982 Td
(systematically)Tj
5.7429 0 Td
(increase)Tj
3.4696 0 Td
([)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(].)Tj
-8.0163 -1.304 Td
(Curtis)Tj
2.7099 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(])Tj
1.8538 0 Td
(first)Tj
1.8028 0 Td
(proposed)Tj
3.9515 0 Td
(transforming)Tj
5.5049 0 Td
(pest)Tj
1.8198 0 Td
(populations)Tj
4.9492 0 Td
(by)Tj
1.1793 0 Td
(introducing)Tj
4.9719 0 Td
(translocations)Tj
5.828 0 Td
(that)Tj
-35.7673 -1.2982 Td
(are)Tj
1.4456 0 Td
(expected)Tj
3.7247 0 Td
(to)Tj
1.0261 0 Td
(show)Tj
2.2961 0 Td
(bistable)Tj
3.2655 0 Td
(dynamics)Tj
4.0592 0 Td
(\(cf.)Tj
1.4967 0 Td
([)Tj
0.83 0.64 0.02 0 k
(28)Tj
0 g
(]\).)Tj
2.4151 0 Td
(The)Tj
1.7801 0 Td
(bistable)Tj
3.2655 0 Td
(model)Tj
2.7439 0 Td
(for)Tj
/F8 1 Tf
1.389 0 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
4.456 0 Td
(spread)Tj
-33.3635 -1.2983 Td
(was)Tj
1.6951 0 Td
(introduced)Tj
4.6431 0 Td
(by)Tj
1.1849 0 Td
(Turelli)Tj
2.9139 0 Td
(and)Tj
1.7292 0 Td
(Hoffmann)Tj
4.422 0 Td
([)Tj
0.83 0.64 0.02 0 k
(29)Tj
0 g
(])Tj
1.8482 0 Td
(to)Tj
1.0261 0 Td
(explain)Tj
3.1238 0 Td
(the)Tj
1.4683 0 Td
(rapid)Tj
2.3357 0 Td
(spread)Tj
2.8573 0 Td
(of)Tj
/F8 1 Tf
1.0148 0 Td
[()]TJ
/F9 1 Tf
(Ri,)Tj
1.9956 0 Td
(a)Tj
0.6576 0 Td
(CI-causing)Tj
/F8 1 Tf
-32.9156 -1.3039 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
4.456 0 Td
(variant,)Tj
3.2541 0 Td
(through)Tj
3.4469 0 Td
(California)Tj
4.2463 0 Td
(populations)Tj
4.9493 0 Td
(of)Tj
/F8 1 Tf
1.0148 0 Td
[()-4()20()7(\r)-3()11()10()18()4()4()]TJ
4.507 0 Td
[(\r)10()12()18()4()4()16(\r)]TJ
/F9 1 Tf
(.)Tj
3.9288 0 Td
(Although)Tj
4.0025 0 Td
(this)Tj
-33.8057 -1.2983 Td
(interpretation)Tj
5.7939 0 Td
(of)Tj
/F8 1 Tf
1.0148 0 Td
[()]TJ
/F9 1 Tf
(Ri)Tj
1.7688 0 Td
(dynamics)Tj
4.0592 0 Td
(has)Tj
1.5421 0 Td
(now)Tj
1.9615 0 Td
(been)Tj
2.1203 0 Td
(challenged)Tj
4.4844 0 Td
(by)Tj
1.1849 0 Td
(more)Tj
2.3414 0 Td
(recent)Tj
2.7099 0 Td
(data)Tj
1.9105 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(spread)Tj
2.8573 0 Td
(of)Tj
-36.4929 -1.2982 Td
(natural)Tj
/F8 1 Tf
3.0784 0 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
4.4617 0 Td
(infections)Tj
4.1499 0 Td
([)Tj
0.83 0.64 0.02 0 k
(30)Tj
0 g
(],)Tj
2.0749 0 Td
(3)Tj
0.6973 0 Td
(lines)Tj
2.0693 0 Td
(of)Tj
1.0148 0 Td
(evidence)Tj
3.7077 0 Td
(nevertheless)Tj
5.0853 0 Td
(support)Tj
3.3222 0 Td
(bistability)Tj
4.1272 0 Td
(of)Tj
/F8 1 Tf
1.0148 0 Td
[()]TJ
/F9 1 Tf
(Mel-)Tj
-34.8035 -1.3039 Td
(transinfected)Tj
/F8 1 Tf
5.4311 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.491 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
2.9877 0 Td
([)Tj
0.83 0.64 0.02 0 k
(31)Tj
0 g
(]:)Tj
2.075 0 Td
(\(1\))Tj
1.3776 0 Td
(frequency)Tj
4.1896 0 Td
(dynamics)Tj
4.0535 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4684 0 Td
(original)Tj
3.3278 0 Td
(field)Tj
1.9729 0 Td
(releases)Tj
3.2655 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(],)Tj
2.075 0 Td
(\(2\))Tj
-35.9204 -1.2983 Td
(direct)Tj
2.5284 0 Td
(experimental)Tj
5.4595 0 Td
(evidence)Tj
3.7134 0 Td
(for)Tj
1.3833 0 Td
(lower)Tj
2.4548 0 Td
(fecundity)Tj
3.9798 0 Td
(and)Tj
1.7291 0 Td
(viability)Tj
3.4186 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(32)Tj
0 g
(],)Tj
3.2485 0 Td
(and)Tj
1.7348 0 Td
(\(3\))Tj
1.3719 0 Td
(new)Tj
1.8765 0 Td
(data)Tj
1.9162 0 Td
(show-)Tj
-34.8148 -1.2983 Td
(ing)Tj
1.5023 0 Td
(that)Tj
1.7745 0 Td
(persistent)Tj
4.0932 0 Td
(influx)Tj
2.5625 0 Td
(over)Tj
1.9729 0 Td
(2)Tj
0.6973 0 Td
(years)Tj
2.262 0 Td
(of)Tj
/F8 1 Tf
1.0148 0 Td
[()]TJ
/F9 1 Tf
(Mel-infected)Tj
/F8 1 Tf
5.9981 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.491 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
2.9877 0 Td
(into)Tj
1.8425 0 Td
(a)Tj
0.652 0 Td
(relatively)Tj
3.8381 0 Td
(isolated)Tj
-32.6889 -1.3039 Td
(population)Tj
4.5864 0 Td
(has)Tj
1.5477 0 Td
(not)Tj
1.5704 0 Td
(led)Tj
1.4173 0 Td
(to)Tj
1.0261 0 Td
(establishment)Tj
5.7373 0 Td
(of)Tj
/F8 1 Tf
1.0148 0 Td
[()]TJ
/F9 1 Tf
(Mel)Tj
2.4435 0 Td
(there)Tj
2.2677 0 Td
([)Tj
0.83 0.64 0.02 0 k
(31)Tj
0 g
(].)Tj
-20.415 -1.2983 Td
(In)Tj
1.1111 0 Td
(order)Tj
2.4208 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(invasion)Tj
3.6057 0 Td
(to)Tj
1.0261 0 Td
(spread)Tj
2.8573 0 Td
(spatially)Tj
3.4753 0 Td
(under)Tj
2.6192 0 Td
(bistability,)Tj
4.3539 0 Td
(new)Tj
1.8766 0 Td
(uncolonised)Tj
5.108 0 Td
(areas)Tj
2.245 0 Td
(must)Tj
-34.7525 -1.2982 Td
(receive)Tj
3.0047 0 Td
(infected)Tj
3.4242 0 Td
(immigrants)Tj
4.8699 0 Td
(at)Tj
0.9524 0 Td
(a)Tj
0.652 0 Td
(rate)Tj
1.7461 0 Td
(high)Tj
2.0126 0 Td
(enough)Tj
3.2145 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(pushed)Tj
3.1067 0 Td
(past)Tj
1.8312 0 Td
(the)Tj
1.4683 0 Td
(threshold)Tj
4.0082 0 Td
(frequency,)Tj
/F15 1 Tf
0 Tc
-32.4565 -1.2359 Td
(^)Tj
/F8 1 Tf
-0.0113 -0.0794 Td
[()]TJ
/F9 1 Tf
-0.004 Tc
0.5272 0 Td
(.)Tj
0.4479 0 Td
(Under)Tj
2.8233 0 Td
(the)Tj
1.474 0 Td
(dynamics)Tj
4.0535 0 Td
(produced)Tj
4.0478 0 Td
(by)Tj
1.1792 0 Td
(CI-inducing)Tj
/F8 1 Tf
5.1534 0 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
(,)Tj
4.6828 0 Td
(spatial)Tj
2.7779 0 Td
(spread)Tj
2.8517 0 Td
(is)Tj
0.8503 0 Td
(expected)Tj
3.7247 0 Td
(in)Tj
1.0319 0 Td
(a)Tj
-35.6256 -1.3153 Td
(habitat)Tj
2.9876 0 Td
(with)Tj
1.9956 0 Td
(relatively)Tj
3.8381 0 Td
(homogeneous)Tj
5.8393 0 Td
(population)Tj
4.5921 0 Td
(densities)Tj
3.6964 0 Td
(if)Tj
/F15 1 Tf
0 Tc
0.788 0.0794 Td
(^)Tj
/F8 1 Tf
-0.017 -0.0794 Td
[()]TJ
/F9 1 Tf
-0.004 Tc
0.754 0 Td
(is)Tj
0.8447 0 Td
(below)Tj
2.5909 0 Td
(a)Tj
0.652 0 Td
(critical)Tj
2.9536 0 Td
(value)Tj
2.3018 0 Td
(near)Tj
2.0012 0 Td
(0.5)Tj
-35.8183 -1.3152 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(29)Tj
0 g
(].)Tj
3.2541 0 Td
(For)Tj
/F8 1 Tf
1.6214 0 Td
[()]TJ
/F9 1 Tf
(Mel)Tj
2.4491 0 Td
(in)Tj
/F8 1 Tf
1.0375 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.4853 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
2.9877 0 Td
(near)Tj
2.0013 0 Td
(Cairns,)Tj
/F15 1 Tf
0 Tc
3.1011 0.0794 Td
(^)Tj
/F8 1 Tf
-0.0114 -0.0794 Td
[()]TJ
/F9 1 Tf
-0.004 Tc
0.7484 0 Td
(is)Tj
0.8447 0 Td
(thought)Tj
3.3732 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(moderate)Tj
4.0252 0 Td
(\()Tj
/F15 1 Tf
0 Tc
0.3515 0.0794 Td
(^)Tj
/F8 1 Tf
-0.0114 -0.0794 Td
[()]TJ
/F16 1 Tf
0.8051 0 Td
()Tj
/F15 1 Tf
1.0488 0 Td
(0)Tj
/F17 1 Tf
(:)Tj
/F15 1 Tf
(2)Tj
/F16 1 Tf
1.4967 0 Td
( )Tj
/F15 1 Tf
0.9921 0 Td
(0)Tj
/F17 1 Tf
(:)Tj
/F15 1 Tf
(35)Tj
/F9 1 Tf
-0.004 Tc
(\))Tj
-33.7774 -1.3039 Td
(because)Tj
3.3165 0 Td
(of)Tj
1.0148 0 Td
(its)Tj
1.1508 0 Td
(relatively)Tj
3.8381 0 Td
(low)Tj
1.6554 0 Td
(fitness)Tj
2.7666 0 Td
(costs)Tj
2.1714 0 Td
(and)Tj
1.7291 0 Td
(near-perfect)Tj
5.0966 0 Td
(maternal)Tj
3.7928 0 Td
(transmission)Tj
5.3688 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(31)Tj
0 g
(].)Tj
-30.7047 -1.2983 Td
(Previously,)Tj
/F8 1 Tf
4.6204 0 Td
[()]TJ
/F9 1 Tf
(Mel-infected)Tj
/F8 1 Tf
5.9981 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.491 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
2.982 0 Td
(released)Tj
3.4299 0 Td
(in)Tj
1.0375 0 Td
(2)Tj
0.6973 0 Td
(relatively)Tj
3.8381 0 Td
(isolated)Tj
3.2882 0 Td
(communities)Tj
5.4821 0 Td
(in)Tj
-34.0608 -1.2983 Td
(Northern)Tj
4.0024 0 Td
(Queensland,)Tj
5.2328 0 Td
(Australia)Tj
3.8437 0 Td
(\(Gordonvale)Tj
5.2951 0 Td
(and)Tj
1.7291 0 Td
(Yorkeys)Tj
3.4696 0 Td
(Knob\),)Tj
3.0217 0 Td
(colonised)Tj
4.0309 0 Td
(each)Tj
2.0296 0 Td
(area)Tj
1.8822 0 Td
(rapidly)Tj
-34.5371 -1.2982 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(],)Tj
2.0749 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(infection)Tj
3.7871 0 Td
(has)Tj
1.542 0 Td
(persisted)Tj
3.7758 0 Td
(at)Tj
0.9524 0 Td
(high)Tj
2.0069 0 Td
(frequency)Tj
4.1839 0 Td
(\()Tj
/F17 1 Tf
0 Tc
(>)Tj
/F9 1 Tf
-0.004 Tc
(90%\))Tj
3.3846 0 Td
(at)Tj
0.9524 0 Td
(both)Tj
2.0579 0 Td
(sites)Tj
1.9276 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(].)Tj
2.0806 0 Td
(Moreover,)Tj
/F8 1 Tf
-31.9292 -1.304 Td
[()]TJ
/F9 1 Tf
(Mel)Tj
2.4434 0 Td
(continues)Tj
4.1272 0 Td
(to)Tj
1.0262 0 Td
(show)Tj
2.296 0 Td
(strong)Tj
2.7723 0 Td
(blockage)Tj
3.7247 0 Td
(of)Tj
1.0148 0 Td
(dengue)Tj
3.1351 0 Td
(transmission)Tj
5.3631 0 Td
(in)Tj
1.0375 0 Td
(laboratory-challenged)Tj
-26.9403 -1.2982 Td
(mosquitoes)Tj
4.7961 0 Td
(derived)Tj
3.2145 0 Td
(from)Tj
2.211 0 Td
(field)Tj
1.9672 0 Td
(collections)Tj
4.4731 0 Td
([)Tj
0.83 0.64 0.02 0 k
(33)Tj
0 g
(].)Tj
2.0806 0 Td
(Here)Tj
2.2053 0 Td
(we)Tj
1.3267 0 Td
(present)Tj
3.1634 0 Td
(data)Tj
1.9105 0 Td
(from)Tj
2.211 0 Td
(3)Tj
0.6917 0 Td
(subsequent)Tj
-30.2511 -1.2983 Td
(releases)Tj
3.2598 0 Td
(of)Tj
/F8 1 Tf
1.0148 0 Td
[()]TJ
/F9 1 Tf
(Mel-infected)Tj
/F8 1 Tf
5.998 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.4911 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
2.9877 0 Td
(in)Tj
1.0374 0 Td
(Cairns,)Tj
3.0898 0 Td
(Northern)Tj
4.0025 0 Td
(Queensland,)Tj
5.2327 0 Td
(a)Tj
0.652 0 Td
(city)Tj
1.6667 0 Td
(with)Tj
1.9956 0 Td
(about)Tj
-32.4281 -1.3039 Td
(150,000)Tj
3.2995 0 Td
(residents)Tj
3.7984 0 Td
(that)Tj
1.7801 0 Td
(is)Tj
0.8504 0 Td
(located)Tj
3.0784 0 Td
(between)Tj
3.5263 0 Td
(the)Tj
1.474 0 Td
(communities)Tj
5.4822 0 Td
(of)Tj
1.0147 0 Td
(Gordonvale)Tj
4.955 0 Td
(and)Tj
1.7291 0 Td
(Yorkeys)Tj
3.4639 0 Td
(Knob.)Tj
-34.452 -1.2983 Td
(These)Tj
2.5681 0 Td
(releases)Tj
3.2598 0 Td
(followed)Tj
3.651 0 Td
(protocols)Tj
3.9572 0 Td
(similar)Tj
2.9877 0 Td
(to)Tj
1.0261 0 Td
(those)Tj
2.3358 0 Td
(of)Tj
1.0147 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(],)Tj
2.075 0 Td
(but)Tj
1.5534 0 Td
(the)Tj
1.474 0 Td
(release)Tj
2.9026 0 Td
(zones)Tj
2.4718 0 Td
(were)Tj
2.1203 0 Td
(centred)Tj
-33.3975 -1.2982 Td
(within)Tj
2.8119 0 Td
(suburban)Tj
4.0025 0 Td
(landscapes,)Tj
4.7225 0 Td
(providing)Tj
4.1442 0 Td
(a)Tj
0.6576 0 Td
(continuous)Tj
4.7339 0 Td
(habitat)Tj
2.9877 0 Td
(for)Tj
/F8 1 Tf
1.3889 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.4854 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
(.)Tj
3.2145 0 Td
(This)Tj
1.9842 0 Td
(study)Tj
2.3924 0 Td
(investi-)Tj
-34.5257 -1.304 Td
(gates)Tj
2.1996 0 Td
(the)Tj
1.4684 0 Td
(capability)Tj
4.0705 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
/F8 1 Tf
1.4683 0 Td
[()]TJ
/F9 1 Tf
(Mel)Tj
2.4491 0 Td
(infection)Tj
3.7928 0 Td
(to)Tj
1.0204 0 Td
(spread)Tj
2.8573 0 Td
(spatially)Tj
3.481 0 Td
(through)Tj
3.4412 0 Td
(urban)Tj
/F8 1 Tf
2.6079 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.491 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
2.9877 0 Td
(popula-)Tj
-34.35 -1.2982 Td
(tions)Tj
2.1996 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4741 0 Td
(stability)Tj
3.3505 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(infection)Tj
3.7927 0 Td
(in)Tj
1.0375 0 Td
(invaded)Tj
3.4016 0 Td
(regions)Tj
3.1634 0 Td
(over)Tj
1.9786 0 Td
(time.)Tj
-23.414 -1.2983 Td
(Spread)Tj
2.9707 0 Td
(from)Tj
2.2053 0 Td
(localized)Tj
3.7077 0 Td
(releases)Tj
3.2655 0 Td
(to)Tj
1.0261 0 Td
(surrounding)Tj
5.2441 0 Td
(uninfected)Tj
4.4957 0 Td
(areas)Tj
2.245 0 Td
(depends)Tj
3.549 0 Td
(on)Tj
1.2756 0 Td
(mosquito)Tj
4.0138 0 Td
(dis-)Tj
-35.1947 -1.2982 Td
(persal)Tj
2.5738 0 Td
(and)Tj
1.7291 0 Td
(relative)Tj
3.1408 0 Td
(population)Tj
4.5864 0 Td
(densities.)Tj
3.9231 0 Td
(Spatial)Tj
2.8914 0 Td
(spread)Tj
2.8573 0 Td
(can)Tj
1.627 0 Td
(be)Tj
1.1509 0 Td
(slowed)Tj
2.965 0 Td
(or)Tj
1.0999 0 Td
(stopped)Tj
3.3732 0 Td
(if)Tj
0.7766 0 Td
(densities)Tj
-32.6945 -1.304 Td
(are)Tj
1.4456 0 Td
(higher)Tj
2.8063 0 Td
(in)Tj
1.0318 0 Td
(surrounding)Tj
5.2441 0 Td
(uninfected)Tj
4.4957 0 Td
(areas)Tj
2.245 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(].)Tj
2.075 0 Td
(Dispersal)Tj
3.9401 0 Td
(of)Tj
/F8 1 Tf
1.0148 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.491 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
2.9877 0 Td
(varies)Tj
2.5285 0 Td
(with)Tj
2.0012 0 Td
(local)Tj
2.075 0 Td
(envi-)Tj
-35.3818 -1.2982 Td
(ronmental)Tj
4.4163 0 Td
(conditions.)Tj
4.6998 0 Td
(Poor)Tj
2.1657 0 Td
(habitats)Tj
3.3448 0 Td
(generally)Tj
3.8324 0 Td
(induce)Tj
2.9424 0 Td
(larger)Tj
2.5285 0 Td
(dispersal)Tj
3.7303 0 Td
(distances)Tj
3.8665 0 Td
(as)Tj
1.0148 0 Td
(gravid)Tj
-32.5415 -1.2983 Td
(females)Tj
3.2144 0 Td
(must)Tj
2.228 0 Td
(travel)Tj
2.4492 0 Td
(further)Tj
3.0273 0 Td
(to)Tj
1.0262 0 Td
(find)Tj
1.8481 0 Td
(the)Tj
1.4684 0 Td
(relatively)Tj
3.8437 0 Td
(rare)Tj
1.8199 0 Td
(oviposition)Tj
4.7225 0 Td
(sites)Tj
1.9275 0 Td
([)Tj
0.83 0.64 0.02 0 k
(34)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(35)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(36)Tj
0 g
(].)Tj
4.4334 0 Td
(Despite)Tj
3.2428 0 Td
(its)Tj
-35.2514 -1.3039 Td
(global)Tj
2.6248 0 Td
(success)Tj
3.1011 0 Td
(as)Tj
1.0148 0 Td
(an)Tj
1.2019 0 Td
(invasive)Tj
3.4299 0 Td
(species)Tj
2.999 0 Td
(in)Tj
1.0318 0 Td
(tropical)Tj
3.2882 0 Td
(habitats,)Tj
3.5716 0 Td
(presumably)Tj
4.8812 0 Td
(through)Tj
3.447 0 Td
(dispersal)Tj
3.7303 0 Td
(of)Tj
1.0148 0 Td
(eggs)Tj
-35.3364 -1.2983 Td
(and)Tj
1.7291 0 Td
(larvae)Tj
2.5852 0 Td
([)Tj
0.83 0.64 0.02 0 k
(37)Tj
0 g
(],)Tj
2.0749 0 Td
(adult)Tj
/F8 1 Tf
2.2564 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.491 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
2.982 0 Td
(are)Tj
1.4513 0 Td
(generally)Tj
3.8325 0 Td
(considered)Tj
4.6034 0 Td
(weak)Tj
2.2564 0 Td
(dispersers.)Tj
4.4276 0 Td
(Females)Tj
3.4583 0 Td
(usually)Tj
-33.1481 -1.2982 Td
(remain)Tj
3.084 0 Td
(within)Tj
2.812 0 Td
(50150)Tj
3.1181 0 Td
(m)Tj
1.0374 0 Td
(of)Tj
1.0148 0 Td
(their)Tj
2.109 0 Td
(eclosion)Tj
3.5036 0 Td
(site)Tj
1.5704 0 Td
([)Tj
0.83 0.64 0.02 0 k
(34)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(38)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(39)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(40)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(41)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(42)Tj
0 g
(].)Tj
7.9596 0 Td
(They)Tj
2.2337 0 Td
(appear)Tj
2.9197 0 Td
(to)Tj
1.0261 0 Td
(disperse)Tj
-32.3884 -1.304 Td
(poorly)Tj
2.8232 0 Td
(across)Tj
2.6759 0 Td
(highways)Tj
3.9402 0 Td
([)Tj
0.83 0.64 0.02 0 k
(31)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(42)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(43)Tj
0 g
(])Tj
4.2065 0 Td
(and)Tj
1.7292 0 Td
(through)Tj
3.4469 0 Td
(vegetated)Tj
3.9685 0 Td
(parkland)Tj
3.7927 0 Td
([)Tj
0.83 0.64 0.02 0 k
(44)Tj
0 g
(].)Tj
2.0806 0 Td
(Occasional)Tj
4.6091 0 Td
(long-)Tj
-33.2728 -1.2982 Td
(range)Tj
2.4604 0 Td
(dispersal,)Tj
3.9571 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4684 0 Td
(order)Tj
2.4207 0 Td
(of)Tj
1.0148 0 Td
(0.51)Tj
2.3868 0 Td
(km,)Tj
1.7631 0 Td
(has)Tj
1.5421 0 Td
(been)Tj
2.1259 0 Td
(observed)Tj
3.7928 0 Td
([)Tj
0.83 0.64 0.02 0 k
(45)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(46)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(47)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(48)Tj
0 g
(].)Tj
5.6069 0 Td
(However,)Tj
4.0762 0 Td
(given)Tj
2.381 0 Td
(the)Tj
-36.2718 -1.2983 Td
(bistable)Tj
3.2598 0 Td
(dynamics)Tj
4.0592 0 Td
(of)Tj
/F8 1 Tf
1.0148 0 Td
[()]TJ
/F9 1 Tf
(Mel)Tj
2.4434 0 Td
(in)Tj
/F8 1 Tf
1.0375 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.491 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
(,)Tj
3.2088 0 Td
(rare)Tj
1.8255 0 Td
(long-range)Tj
4.5751 0 Td
(dispersal)Tj
3.7304 0 Td
(will)Tj
1.6667 0 Td
(not)Tj
1.5704 0 Td
(accelerate)Tj
/F8 1 Tf
4.1215 0 Td
[()92()10()14()4( )]TJ
-34.0041 -1.3039 Td
[()13()18()4()]TJ
/F9 1 Tf
1.8481 0 Td
(spread)Tj
2.8573 0 Td
(because)Tj
3.3222 0 Td
(the)Tj
1.4684 0 Td
(infection)Tj
3.7927 0 Td
(will)Tj
1.6611 0 Td
(not)Tj
1.576 0 Td
(increase)Tj
3.4696 0 Td
(locally)Tj
2.7779 0 Td
(from)Tj
2.2054 0 Td
(low)Tj
1.6554 0 Td
(initial)Tj
2.5512 0 Td
(frequencies)Tj
4.7848 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(31)Tj
0 g
(].)Tj
-32.7739 -1.2983 Td
(We)Tj
1.61 0 Td
(document)Tj
4.2973 0 Td
(local)Tj
/F8 1 Tf
2.075 0 Td
[()]TJ
/F9 1 Tf
(Mel)Tj
2.4491 0 Td
(establishment)Tj
5.7373 0 Td
(and)Tj
1.7291 0 Td
(heterogeneous)Tj
6.0264 0 Td
(spatial)Tj
2.778 0 Td
(spread)Tj
2.8516 0 Td
(from)Tj
2.211 0 Td
(the)Tj
1.4683 0 Td
(2)Tj
0.6974 0 Td
(rela-)Tj
-35.1267 -1.2982 Td
(tively)Tj
2.364 0 Td
(large)Tj
2.16 0 Td
(release)Tj
2.9027 0 Td
(areas.)Tj
2.4661 0 Td
(Our)Tj
1.8709 0 Td
(new)Tj
1.8765 0 Td
(data)Tj
1.9105 0 Td
(demonstrate)Tj
5.2327 0 Td
(that)Tj
1.7802 0 Td
(local)Tj
/F8 1 Tf
2.0749 0 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
4.4617 0 Td
(introductions)Tj
-29.1002 -1.2983 Td
(can)Tj
1.627 0 Td
(succeed,)Tj
3.5546 0 Td
(persist)Tj
2.8177 0 Td
(for)Tj
1.3889 0 Td
(at)Tj
0.9525 0 Td
(least)Tj
1.9785 0 Td
(2)Tj
0.6974 0 Td
(years,)Tj
2.4888 0 Td
(and)Tj
1.7291 0 Td
(produce)Tj
3.5206 0 Td
(slow)Tj
2.0182 0 Td
(spatial)Tj
2.778 0 Td
(spread.)Tj
3.0784 0 Td
(Using)Tj
2.6022 0 Td
(graphical)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 129.8268 23.6976 re
W* n
q
129.7701 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 371.9622 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Spread)Tj
3.3874 0 Td
(of)Tj
1.0417 0 Td
(dengue-suppr)Tj
6.0591 0 Td
(essing)Tj
/F7 1 Tf
3.0544 0 Td
(Wolbachi)Tj
4.0394 0 Td
(a)Tj
/F0 1 Tf
0.7653 0 Td
(in)Tj
/F7 1 Tf
0.978 0 Td
(Aedes)Tj
3.0118 0 Td
(aegypti)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
90.1417 34.9228 m
243.8362 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Biology)Tj
3.437 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.pb)Tj
5.1236 0 Td
(io.2001894)Tj
0 g
5.8536 0 Td
(May)Tj
2.0835 0 Td
(30,)Tj
1.5874 0 Td
(2017)Tj
34.4908 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
118 0 obj
<>stream
endstream
endobj
119 0 obj
<>stream
endstream
endobj
120 0 obj
<>stream
endstream
endobj
121 0 obj
<>stream
endstream
endobj
122 0 obj
<>stream
endstream
endobj
123 0 obj
<>stream
endstream
endobj
124 0 obj
<>stream
endstream
endobj
125 0 obj
<>stream
endstream
endobj
126 0 obj
<>stream
endstream
endobj
127 0 obj
<>stream
endstream
endobj
128 0 obj
<>stream
endstream
endobj
129 0 obj
<>stream
endstream
endobj
130 0 obj
<>stream
endstream
endobj
131 0 obj
<>stream
endstream
endobj
132 0 obj
<>stream
endstream
endobj
133 0 obj
<>stream
endstream
endobj
134 0 obj
<>stream
endstream
endobj
135 0 obj
<>stream
endstream
endobj
136 0 obj
<>stream
endstream
endobj
137 0 obj
<>stream
endstream
endobj
138 0 obj
<>stream
endstream
endobj
139 0 obj
<>stream
endstream
endobj
140 0 obj
<>stream
endstream
endobj
141 0 obj
<>stream
endstream
endobj
142 0 obj
<>stream
endstream
endobj
143 0 obj
<>stream
endstream
endobj
144 0 obj
<>stream
endstream
endobj
145 0 obj
<>stream
endstream
endobj
146 0 obj
<>stream
endstream
endobj
147 0 obj
<>stream
endstream
endobj
148 0 obj
<>stream
endstream
endobj
149 0 obj
<>stream
endstream
endobj
150 0 obj
<>stream
BT
66.402 0 Td
(28)Tj
ET
Q
endstream
endobj
151 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 152 0 R/Contents 153 0 R/TrimBox[0 0 612 792]>>
endobj
152 0 obj
[154 0 R 155 0 R 156 0 R 157 0 R 158 0 R 159 0 R 160 0 R 161 0 R 162 0 R 163 0 R 164 0 R 165 0 R 166 0 R 167 0 R 168 0 R]
endobj
154 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref031)>>
endobj
155 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref049)>>
endobj
156 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref020)>>
endobj
157 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref024)>>
endobj
158 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref031)>>
endobj
159 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref050)>>
endobj
160 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref020)>>
endobj
161 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref020)>>
endobj
162 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref041)>>
endobj
163 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref051)>>
endobj
164 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.ref032)>>
endobj
165 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.g001)>>
endobj
166 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.s006)>>
endobj
167 0 obj
<>/Border[0 0 0]/Dest(Rpbio.2001894.g002)>>
endobj
168 0 obj
<>/Border[0 0 0]/A 169 0 R>>
endobj
169 0 obj
<>
endobj
153 0 obj
[170 0 R 171 0 R 172 0 R 173 0 R 174 0 R 175 0 R 176 0 R 177 0 R 178 0 R 179 0 R 180 0 R 181 0 R 182 0 R 183 0 R]
endobj
170 0 obj
<>stream
q
0.83 0.64 0.02 0 k
389.4803 641.1969 m
399.0047 641.1969 l
h
f*
441.0142 602.1921 m
450.5386 602.1921 l
h
f*
240.6047 536.9953 m
250.1291 536.9953 l
h
f*
252.3969 536.9953 m
261.9213 536.9953 l
h
f*
264.1323 536.9953 m
273.6567 536.9953 l
h
f*
275.9244 536.9953 m
285.4488 536.9953 l
h
f*
388.6299 420.0378 m
398.1543 420.0378 l
h
f*
401.8961 381.0331 m
411.3638 381.0331 l
h
f*
203.4142 355.011 m
212.9386 355.011 l
h
f*
215.1496 355.011 m
224.674 355.011 l
h
f*
357.6189 328.989 m
367.1433 328.989 l
h
f*
200.0126 224.9008 m
219.4583 224.9008 l
h
f*
210.2173 146.948 m
243.7228 146.948 l
h
f*
451.2189 81.9213 m
470.778 81.9213 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(summaries,)Tj
4.8302 0 Td
(we)Tj
1.3266 0 Td
(approximate)Tj
5.2724 0 Td
(the)Tj
1.474 0 Td
(rate)Tj
1.7461 0 Td
(of)Tj
1.0148 0 Td
(spatial)Tj
2.7779 0 Td
(spread)Tj
2.8517 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(width)Tj
2.5228 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(spreading)Tj
4.1385 0 Td
(wave.)Tj
2.4435 0 Td
(We)Tj
-36.0848 -1.3039 Td
(also)Tj
1.7688 0 Td
(show)Tj
2.296 0 Td
(that)Tj
1.7802 0 Td
(our)Tj
1.627 0 Td
(field)Tj
1.9729 0 Td
(data)Tj
1.9106 0 Td
(are)Tj
1.4513 0 Td
(broadly)Tj
3.2655 0 Td
(consistent)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(simple)Tj
2.8573 0 Td
(mathematical)Tj
5.6466 0 Td
(models)Tj
3.1067 0 Td
(that)Tj
-33.9361 -1.2982 Td
(depend)Tj
3.1861 0 Td
(critically)Tj
3.651 0 Td
(on)Tj
1.2756 0 Td
(bistable)Tj
3.2654 0 Td
(frequency)Tj
4.1896 0 Td
(dynamics)Tj
4.0535 0 Td
(for)Tj
/F8 1 Tf
1.389 0 Td
[()]TJ
/F9 1 Tf
(Mel)Tj
2.4435 0 Td
(transinfected)Tj
5.4368 0 Td
(into)Tj
/F8 1 Tf
1.8368 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.491 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
(.)Tj
-32.2183 -1.2983 Td
(These)Tj
2.5681 0 Td
(models)Tj
3.1011 0 Td
(involve)Tj
3.1238 0 Td
(only)Tj
1.9785 0 Td
(2)Tj
0.6917 0 Td
(parameters,)Tj
4.8982 0 Td
(one)Tj
1.7008 0 Td
(describing)Tj
4.3823 0 Td
(the)Tj
1.4684 0 Td
(position)Tj
3.4922 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(unstable)Tj
3.566 0 Td
(threshold)Tj
-33.4599 -1.3153 Td
(point,)Tj
/F15 1 Tf
0 Tc
2.5965 0.0794 Td
(^)Tj
/F8 1 Tf
-0.0114 -0.0794 Td
[()]TJ
/F9 1 Tf
-0.004 Tc
0.5273 0 Td
(,)Tj
0.4422 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4683 0 Td
(other,)Tj
/F8 1 Tf
2.5738 0 Td
[()]TJ
/F9 1 Tf
(,)Tj
0.9071 0 Td
(describing)Tj
4.3824 0 Td
(average)Tj
/F8 1 Tf
3.2258 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.491 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
2.9877 0 Td
(dispersal)Tj
3.7303 0 Td
(distance.)Tj
3.7304 0 Td
(Both)Tj
2.1317 0 Td
(parameters)Tj
-31.9179 -1.2982 Td
(can)Tj
1.627 0 Td
(be)Tj
1.1509 0 Td
(estimated)Tj
4.0705 0 Td
(independently)Tj
5.9754 0 Td
(of)Tj
1.0148 0 Td
(spread)Tj
2.8573 0 Td
(data)Tj
1.9105 0 Td
([)Tj
0.83 0.64 0.02 0 k
(31)Tj
0 g
(].)Tj
2.075 0 Td
(We)Tj
1.6101 0 Td
(also)Tj
1.7688 0 Td
(present)Tj
3.1634 0 Td
(likelihood-based)Tj
6.8428 0 Td
(data)Tj
-34.0665 -1.304 Td
(analyses)Tj
3.4809 0 Td
(that)Tj
1.7801 0 Td
(fit)Tj
1.0715 0 Td
(simple)Tj
2.8573 0 Td
(curves)Tj
2.7779 0 Td
(to)Tj
1.0262 0 Td
(estimate)Tj
3.5489 0 Td
(the)Tj
1.4684 0 Td
(shape)Tj
2.4831 0 Td
(and)Tj
1.7291 0 Td
(speed)Tj
2.4718 0 Td
(of)Tj
/F8 1 Tf
1.0148 0 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
4.4617 0 Td
(spread.)Tj
3.0784 0 Td
(The)Tj
1.7802 0 Td
(shape)Tj
-35.0303 -1.2982 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(advancing)Tj
4.3256 0 Td
(wave)Tj
2.2167 0 Td
(is)Tj
0.8447 0 Td
(summarized)Tj
5.1874 0 Td
(by)Tj
1.1792 0 Td
(wave)Tj
2.2167 0 Td
(width,)Tj
2.7496 0 Td
(defined)Tj
3.2258 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(inverse)Tj
3.0727 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(maximum)Tj
-32.4678 -1.2983 Td
(slope)Tj
2.2733 0 Td
(in)Tj
1.0375 0 Td
(infection)Tj
3.7927 0 Td
(frequencies,)Tj
5.006 0 Td
(averaged)Tj
3.753 0 Td
(over)Tj
1.9786 0 Td
(the)Tj
1.4683 0 Td
(wave)Tj
2.2167 0 Td
(front)Tj
2.2337 0 Td
([)Tj
0.83 0.64 0.02 0 k
(49)Tj
0 g
(].)Tj
2.0749 0 Td
(As)Tj
1.27 0 Td
(discussed)Tj
3.9968 0 Td
(below,)Tj
2.8119 0 Td
(wave)Tj
-33.9134 -1.3039 Td
(width)Tj
2.5228 0 Td
(provides)Tj
3.651 0 Td
(an)Tj
1.2019 0 Td
(estimate)Tj
3.5432 0 Td
(of)Tj
1.0148 0 Td
(dispersal)Tj
3.7304 0 Td
(distance)Tj
3.5036 0 Td
(averaged)Tj
3.7531 0 Td
(over)Tj
1.9785 0 Td
(time.)Tj
2.2564 0 Td
(Wave)Tj
2.4945 0 Td
(speed)Tj
2.4718 0 Td
(is)Tj
0.8503 0 Td
(defined)Tj
3.2258 0 Td
(as)Tj
-36.1981 -1.2983 Td
(the)Tj
1.4683 0 Td
(average)Tj
3.2258 0 Td
(rate)Tj
1.7461 0 Td
(of)Tj
1.0148 0 Td
(movement)Tj
4.5184 0 Td
(of)Tj
1.0148 0 Td
(an)Tj
1.2019 0 Td
(intermediate)Tj
5.3234 0 Td
(infection)Tj
3.7871 0 Td
(frequency)Tj
4.1896 0 Td
(\(e.g.,)Tj
2.1259 0 Td
(0.5.\))Tj
1.9616 0 Td
(The)Tj
1.7802 0 Td
(theory)Tj
2.8062 0 Td
(of)Tj
-36.1641 -1.3152 Td
(bistable)Tj
3.2598 0 Td
(waves)Tj
2.5795 0 Td
(leads)Tj
2.211 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.6577 0 Td
(simple)Tj
2.8516 0 Td
(prediction)Tj
4.371 0 Td
(for)Tj
1.389 0 Td
(wave)Tj
2.2166 0 Td
(speed)Tj
2.4718 0 Td
(in)Tj
1.0318 0 Td
(terms)Tj
2.4945 0 Td
(of)Tj
1.0148 0 Td
(wave)Tj
2.2167 0 Td
(width)Tj
2.5285 0 Td
(and)Tj
/F15 1 Tf
0 Tc
1.7404 0.0793 Td
(^)Tj
/F8 1 Tf
-0.0113 -0.0793 Td
[()]TJ
/F9 1 Tf
-0.004 Tc
0.5272 0 Td
(,)Tj
0.4479 0 Td
(the)Tj
-35.0246 -1.2983 Td
(threshold)Tj
4.0081 0 Td
(infection)Tj
3.7927 0 Td
(frequency)Tj
4.1896 0 Td
(above)Tj
2.5455 0 Td
(which)Tj
2.6476 0 Td
(local)Tj
2.0806 0 Td
(increases)Tj
3.8324 0 Td
(in)Tj
1.0318 0 Td
(infection)Tj
3.7927 0 Td
(frequencies)Tj
4.7849 0 Td
(\()Tj
/F8 1 Tf
[()]TJ
/F9 1 Tf
(\))Tj
1.3776 0 Td
(are)Tj
-34.0835 -1.3039 Td
(expected)Tj
3.719 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(31)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(50)Tj
0 g
(].)Tj
5.6069 0 Td
(The)Tj
1.7858 0 Td
(observed)Tj
3.7927 0 Td
(speed)Tj
2.4718 0 Td
(of)Tj
/F8 1 Tf
1.0148 0 Td
[()]TJ
/F9 1 Tf
(Mel)Tj
2.4491 0 Td
(spread)Tj
2.8517 0 Td
(in)Tj
1.0374 0 Td
(Cairns)Tj
2.8687 0 Td
(is)Tj
0.8447 0 Td
(broadly)Tj
3.2712 0 Td
(compatible)Tj
-31.7138 -1.2983 Td
(with)Tj
1.9955 0 Td
(this)Tj
1.6725 0 Td
(prediction,)Tj
4.5977 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4741 0 Td
(estimated)Tj
4.0705 0 Td
(wave)Tj
2.2167 0 Td
(width)Tj
2.5228 0 Td
(is)Tj
0.8504 0 Td
(also)Tj
1.7688 0 Td
(consistent)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(independent)Tj
5.2724 0 Td
(esti-)Tj
-34.4237 -1.2982 Td
(mates)Tj
2.5568 0 Td
(of)Tj
1.0148 0 Td
(dispersal.)Tj
3.9515 0 Td
(Moreover,)Tj
4.3993 0 Td
(the)Tj
1.4683 0 Td
(lack)Tj
1.8199 0 Td
(of)Tj
1.0148 0 Td
(clear)Tj
2.1203 0 Td
(establishment)Tj
5.7316 0 Td
(or)Tj
1.0998 0 Td
(spread)Tj
2.8573 0 Td
(from)Tj
2.2054 0 Td
(our)Tj
1.627 0 Td
(third,)Tj
2.4378 0 Td
(signifi-)Tj
-34.3046 -1.304 Td
(cantly)Tj
2.6248 0 Td
(smaller,)Tj
3.3449 0 Td
(release)Tj
2.9026 0 Td
(area)Tj
1.8822 0 Td
(\(only)Tj
2.3188 0 Td
(0.11)Tj
1.8708 0 Td
(km)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 362.6078 503.5464 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 366.1795 499.0677 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\))Tj
0.5612 0 Td
(is)Tj
0.8504 0 Td
(consistent)Tj
4.2519 0 Td
(with)Tj
2.0013 0 Td
(the)Tj
1.4683 0 Td
(prediction)Tj
4.371 0 Td
(for)Tj
1.389 0 Td
(bistable)Tj
-31.5096 -1.2982 Td
(dynamics)Tj
4.0535 0 Td
(that)Tj
1.7801 0 Td
(releases)Tj
3.2655 0 Td
(must)Tj
2.2224 0 Td
(be)Tj
1.1508 0 Td
(conducted)Tj
4.4276 0 Td
(over)Tj
1.9786 0 Td
(sufficiently)Tj
4.6148 0 Td
(large)Tj
2.1599 0 Td
(areas)Tj
2.2451 0 Td
(to)Tj
1.0204 0 Td
(initiate)Tj
3.0274 0 Td
(spatial)Tj
2.778 0 Td
(spread.)Tj
-33.5279 -1.2983 Td
(Our)Tj
1.8708 0 Td
(likelihood)Tj
4.235 0 Td
(analyses)Tj
3.4809 0 Td
(also)Tj
1.7688 0 Td
(quantify)Tj
3.5433 0 Td
(significant)Tj
4.3879 0 Td
(heterogeneity)Tj
5.6522 0 Td
(in)Tj
1.0375 0 Td
(rates)Tj
2.109 0 Td
(of)Tj
1.0148 0 Td
(spatial)Tj
2.7779 0 Td
(spread)Tj
2.8516 0 Td
(that)Tj
-35.9259 -1.2982 Td
(is)Tj
0.8447 0 Td
(apparent)Tj
3.7644 0 Td
(from)Tj
2.2053 0 Td
(our)Tj
1.6271 0 Td
(graphical)Tj
3.9061 0 Td
(representations.)Tj
6.5989 0 Td
(We)Tj
1.6101 0 Td
(attempt)Tj
3.3108 0 Td
(to)Tj
1.0262 0 Td
(link)Tj
1.7801 0 Td
(this)Tj
1.6724 0 Td
(heterogeneity)Tj
5.6523 0 Td
(to)Tj
1.0261 0 Td
(easily)Tj
-35.0245 -1.304 Td
(measured)Tj
4.1045 0 Td
(habitat)Tj
2.9877 0 Td
(variables.)Tj
3.9458 0 Td
(Heterogeneity)Tj
5.8903 0 Td
(in)Tj
1.0374 0 Td
(host)Tj
1.9106 0 Td
(population)Tj
4.5921 0 Td
(density)Tj
3.1011 0 Td
(is)Tj
0.8503 0 Td
(expected)Tj
3.7191 0 Td
(to)Tj
1.0261 0 Td
(strongly)Tj
-33.165 -1.2982 Td
(influence)Tj
/F8 1 Tf
3.9174 0 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
4.4561 0 Td
(invasions)Tj
3.9684 0 Td
(subject)Tj
3.0161 0 Td
(to)Tj
1.0261 0 Td
(bistable)Tj
3.2654 0 Td
(dynamics,)Tj
4.2803 0 Td
(especially)Tj
4.0195 0 Td
(affecting)Tj
3.6567 0 Td
(wave)Tj
2.2166 0 Td
(speed)Tj
-33.8226 -1.2983 Td
(and)Tj
1.7291 0 Td
(potentially)Tj
4.4617 0 Td
(restricting)Tj
4.3143 0 Td
(the)Tj
1.4683 0 Td
(extent)Tj
2.6816 0 Td
(of)Tj
1.0148 0 Td
(spread)Tj
2.8515 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(].)Tj
2.075 0 Td
(Even)Tj
2.2166 0 Td
(if)Tj
/F8 1 Tf
0.7767 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.491 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
2.9877 0 Td
(disperse)Tj
3.4696 0 Td
(equally)Tj
3.0614 0 Td
(in)Tj
1.0375 0 Td
(all)Tj
-35.6368 -1.3039 Td
(directions,)Tj
4.439 0 Td
(heterogeneities)Tj
6.2475 0 Td
(in)Tj
1.0375 0 Td
(population)Tj
4.5921 0 Td
(density)Tj
3.101 0 Td
(produce)Tj
3.5149 0 Td
(asymmetries)Tj
5.2554 0 Td
(in)Tj
1.0375 0 Td
(net)Tj
1.491 0 Td
(migration.)Tj
4.422 0 Td
(This)Tj
-35.1379 -1.2983 Td
(asymmetry)Tj
4.6544 0 Td
(accelerates)Tj
4.4844 0 Td
(spread)Tj
2.8516 0 Td
(from)Tj
2.2054 0 Td
(high-density)Tj
5.2439 0 Td
(patches)Tj
3.2032 0 Td
(to)Tj
1.0261 0 Td
(low-density)Tj
4.8869 0 Td
(patches)Tj
3.2088 0 Td
(and)Tj
1.7291 0 Td
(deceler-)Tj
-33.4938 -1.2982 Td
(atesor)Tj
3.5376 0 Td
(haltsspread)Tj
5.6466 0 Td
(out)Tj
1.5533 0 Td
(of)Tj
1.0148 0 Td
(low-density)Tj
4.8868 0 Td
(patches)Tj
3.2088 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(].)Tj
2.075 0 Td
(Habitat)Tj
3.2258 0 Td
(variables)Tj
3.719 0 Td
(such)Tj
2.058 0 Td
(as)Tj
1.0147 0 Td
(shade,)Tj
2.7213 0 Td
(yard)Tj
-34.6617 -1.304 Td
(condition,)Tj
4.3369 0 Td
(and)Tj
1.7292 0 Td
(abundance)Tj
4.5921 0 Td
(of)Tj
1.0148 0 Td
(oviposition)Tj
4.7224 0 Td
(sites)Tj
1.9275 0 Td
(have)Tj
2.0579 0 Td
(been)Tj
2.126 0 Td
(correlated)Tj
4.2406 0 Td
(with)Tj
/F8 1 Tf
1.9956 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.491 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
2.9877 0 Td
(abundance)Tj
-33.2217 -1.2982 Td
([)Tj
0.83 0.64 0.02 0 k
(41)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(51)Tj
0 g
(];)Tj
3.2541 0 Td
(the)Tj
1.4684 0 Td
(frequency)Tj
4.1895 0 Td
(of)Tj
/F8 1 Tf
1.0148 0 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
4.4561 0 Td
(infection)Tj
3.7926 0 Td
(within)Tj
2.8119 0 Td
(the)Tj
1.4684 0 Td
(release)Tj
2.9026 0 Td
(zone)Tj
2.1147 0 Td
(in)Tj
1.0374 0 Td
(Gordonvale,)Tj
5.1761 0 Td
(Queens-)Tj
-33.6866 -1.2983 Td
(land,)Tj
2.1996 0 Td
(was)Tj
1.7008 0 Td
(higher)Tj
2.8006 0 Td
(in)Tj
1.0375 0 Td
(neighbourhoods)Tj
6.7974 0 Td
(with)Tj
1.9956 0 Td
(more)Tj
2.3413 0 Td
(brick)Tj
2.2847 0 Td
(and)Tj
1.7291 0 Td
(screened)Tj
3.7247 0 Td
(houses,)Tj
3.1522 0 Td
(which)Tj
2.6475 0 Td
(are)Tj
1.4513 0 Td
(associ-)Tj
-33.8623 -1.3039 Td
(ated)Tj
1.9048 0 Td
(with)Tj
1.9956 0 Td
(lower)Tj
/F8 1 Tf
2.4491 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
1.491 0 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
2.9877 0 Td
(abundance)Tj
4.5921 0 Td
([)Tj
0.83 0.64 0.02 0 k
(32)Tj
0 g
(].)Tj
2.0806 0 Td
(This)Tj
1.9842 0 Td
(motivates)Tj
4.0875 0 Td
(our)Tj
1.6214 0 Td
(attempts)Tj
3.6737 0 Td
(to)Tj
1.0261 0 Td
(understand)Tj
-29.8938 -1.2983 Td
(patterns)Tj
3.4695 0 Td
(of)Tj
1.0148 0 Td
(local)Tj
2.0807 0 Td
(spread)Tj
2.8516 0 Td
(by)Tj
1.1849 0 Td
(inferring)Tj
3.77 0 Td
(local)Tj
2.075 0 Td
(densities)Tj
3.6962 0 Td
(from)Tj
2.2054 0 Td
(easily)Tj
2.4094 0 Td
(measured)Tj
4.1102 0 Td
(habitat)Tj
2.982 0 Td
(variables.)Tj
-31.8497 -1.2982 Td
(However,)Tj
4.0762 0 Td
(the)Tj
1.4683 0 Td
(variables)Tj
3.719 0 Td
(we)Tj
1.3266 0 Td
(assessed)Tj
3.4753 0 Td
(did)Tj
1.542 0 Td
(not)Tj
1.5703 0 Td
(predict)Tj
3.0501 0 Td
(observed)Tj
3.7984 0 Td
(heterogeneities)Tj
6.2475 0 Td
(in)Tj
1.0375 0 Td
(spread)Tj
2.8516 0 Td
(beyond)Tj
-34.1628 -1.2983 Td
(the)Tj
1.4683 0 Td
(release)Tj
2.9027 0 Td
(zones.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 261.0141 cm
BT
/F3 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Results)Tj
/F0 1 Tf
0 -1.5023 Td
(Mosquito)Tj
4.2283 0 Td
(collections)Tj
4.8284 0 Td
(and)Tj
1.8614 0 Td
(abundance)Tj
ET
Q
q
0.83 0.64 0.02 0 k
1 j
1 J
0 w
10 0 0 10 200.0125 225.9779 cm
BT
/F9 1 Tf
1 TL
-0.009 Tc
0 0 Td
(Fig)Tj
1.4626 0 Td
(1)Tj
0 g
0.6917 0 Td
(shows)Tj
2.6362 0 Td
(the)Tj
1.4513 0 Td
(3)Tj
0.6916 0 Td
(areas)Tj
2.2224 0 Td
(in)Tj
1.0261 0 Td
(Cairns,)Tj
3.0501 0 Td
(Queensland,)Tj
5.1817 0 Td
(where)Tj
2.6249 0 Td
(Eliminate)Tj
4.0478 0 Td
(Dengue)Tj
3.3165 0 Td
(staff)Tj
1.8595 0 Td
(released)Tj
/F8 1 Tf
3.3959 0 Td
[(\n)30()]TJ
/F9 1 Tf
(.)Tj
/F8 1 Tf
-33.6583 -1.2982 Td
[()6()9()-21()-13()12()7()]TJ
/F9 1 Tf
2.948 0 Td
(adults)Tj
2.5851 0 Td
(infected)Tj
3.3789 0 Td
(with)Tj
1.9786 0 Td
(the)Tj
/F8 1 Tf
1.457 0 Td
[()]TJ
/F9 1 Tf
(Mel)Tj
2.4264 0 Td
(strain)Tj
2.4662 0 Td
(of)Tj
/F8 1 Tf
1.0091 0 Td
[()92()10()14()4()6()13()18()4()]TJ
/F9 1 Tf
4.4107 0 Td
(between)Tj
3.4922 0 Td
(January)Tj
3.2882 0 Td
(10th)Tj
1.9786 0 Td
(and)Tj
1.7121 0 Td
(April)Tj
2.279 0 Td
(24th,)Tj
-35.4101 -1.2983 Td
(2013.)Tj
2.3187 0 Td
(The)Tj
1.7688 0 Td
(release)Tj
2.8686 0 Td
(zones,)Tj
2.6702 0 Td
(located)Tj
3.0444 0 Td
(in)Tj
1.0262 0 Td
(the)Tj
1.4513 0 Td
(suburbs)Tj
3.3505 0 Td
(of)Tj
1.0035 0 Td
(Edge)Tj
2.1883 0 Td
(Hill/Whitfield)Tj
5.8167 0 Td
(\(EHW\),)Tj
3.3959 0 Td
(Parramatta)Tj
4.6261 0 Td
(Park)Tj
-35.5292 -1.3039 Td
(\(PP\),)Tj
2.2166 0 Td
(and)Tj
1.7178 0 Td
(Westcourt)Tj
4.3483 0 Td
(\(WC\),)Tj
2.7326 0 Td
(were)Tj
2.0976 0 Td
(within)Tj
2.7836 0 Td
(2)Tj
0.6917 0 Td
(km)Tj
1.525 0 Td
(of)Tj
1.0091 0 Td
(each)Tj
2.007 0 Td
(other)Tj
2.3244 0 Td
(and)Tj
1.7121 0 Td
(encompassed)Tj
5.5105 0 Td
(0.97)Tj
1.8538 0 Td
(km)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 538.3559 191.4519 cm
BT
/F9 1 Tf
1 TL
-0.012 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 541.8708 186.9732 cm
BT
/F9 1 Tf
1 TL
-0.009 Tc
0 0 Td
(,)Tj
0.4422 0 Td
(0.52)Tj
-34.6278 -1.2982 Td
(km)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 213.0519 178.4692 cm
BT
/F9 1 Tf
1 TL
-0.012 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 216.5669 173.9905 cm
BT
/F9 1 Tf
1 TL
-0.009 Tc
0 0 Td
(,)Tj
0.4422 0 Td
(and)Tj
1.7121 0 Td
(0.11)Tj
1.8538 0 Td
(km)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 269.6881 178.4692 cm
BT
/F9 1 Tf
1 TL
-0.012 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 273.2031 173.9905 cm
BT
/F9 1 Tf
1 TL
-0.009 Tc
0 0 Td
(,)Tj
0.4422 0 Td
(respectively.)Tj
5.0456 0 Td
(Mosquitoes)Tj
4.8189 0 Td
(were)Tj
2.1033 0 Td
(released)Tj
3.3902 0 Td
(evenly)Tj
2.7439 0 Td
(throughout)Tj
4.7281 0 Td
(each)Tj
2.007 0 Td
(release)Tj
2.8686 0 Td
(zone)Tj
-35.4668 -1.2982 Td
(at)Tj
0.9411 0 Td
(weekly)Tj
2.9197 0 Td
(intervals.)Tj
3.7983 0 Td
(Total)Tj
2.2904 0 Td
(BG-Sentinel)Tj
5.0456 0 Td
(trap)Tj
1.8199 0 Td
(collections)Tj
4.4163 0 Td
(for)Tj
1.372 0 Td
(EHW,)Tj
2.7269 0 Td
(PP,)Tj
1.5477 0 Td
(and)Tj
1.7178 0 Td
(WC)Tj
1.8368 0 Td
(are)Tj
1.4343 0 Td
(summarised)Tj
-31.8668 -1.2983 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0205 0 Td
(S1)Tj
1.1509 0 Td
(Table)Tj
0 g
(.)Tj
2.6305 0 Td
(Our)Tj
1.8425 0 Td
(collections)Tj
4.4106 0 Td
(continued)Tj
4.2406 0 Td
(for)Tj
1.3663 0 Td
(about)Tj
2.4604 0 Td
(2)Tj
0.686 0 Td
(years)Tj
2.2337 0 Td
(and)Tj
1.7065 0 Td
(are)Tj
1.4286 0 Td
(summarized)Tj
5.125 0 Td
(in)Tj
1.0205 0 Td
(4)Tj
0.686 0 Td
(time)Tj
2.0012 0 Td
(intervals.)Tj
-34.0098 -1.3039 Td
(The)Tj
1.7688 0 Td
(first)Tj
1.7802 0 Td
(dry)Tj
1.559 0 Td
(season)Tj
2.8232 0 Td
(D1)Tj
1.423 0 Td
(\(May)Tj
2.3187 0 Td
(2013October)Tj
5.8564 0 Td
(2013\),)Tj
2.6589 0 Td
(began)Tj
2.5738 0 Td
(immediately)Tj
5.1477 0 Td
(after)Tj
2.0069 0 Td
(the)Tj
1.457 0 Td
(releases,)Tj
3.4412 0 Td
(fol-)Tj
-34.8148 -1.2983 Td
(lowed)Tj
2.5796 0 Td
(by)Tj
1.1735 0 Td
(the)Tj
1.457 0 Td
(first)Tj
1.7801 0 Td
(wet)Tj
1.61 0 Td
(season)Tj
2.8233 0 Td
(W1)Tj
1.6497 0 Td
(\(November)Tj
4.7622 0 Td
(2013April)Tj
4.6715 0 Td
(2014\),)Tj
2.6589 0 Td
(the)Tj
1.457 0 Td
(second)Tj
2.982 0 Td
(dry)Tj
1.559 0 Td
(season)Tj
2.8233 0 Td
(D2)Tj
1.423 0 Td
(\(May)Tj
-35.4101 -1.2982 Td
(2014October)Tj
5.8564 0 Td
(2014\),)Tj
2.6588 0 Td
(and)Tj
1.7121 0 Td
(the)Tj
1.457 0 Td
(second)Tj
2.982 0 Td
(wet)Tj
1.6101 0 Td
(season)Tj
2.8233 0 Td
(W2)Tj
1.6497 0 Td
(\(November)Tj
4.7622 0 Td
(2014April)Tj
4.6715 0 Td
(2015\).)Tj
-0.004 Tc
-28.9868 -1.3039 Td
(Weekly)Tj
3.2314 0 Td
(trap)Tj
1.8425 0 Td
(yields)Tj
2.5001 0 Td
(at)Tj
0.9524 0 Td
(EHW)Tj
2.5228 0 Td
(and)Tj
1.7292 0 Td
(PP)Tj
1.3379 0 Td
(decreased)Tj
4.1386 0 Td
(progressively)Tj
5.4424 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.4683 0 Td
(onset)Tj
2.3584 0 Td
(of)Tj
1.0148 0 Td
(each)Tj
2.0296 0 Td
(dry)Tj
1.5761 0 Td
(sea-)Tj
-35.5462 -1.2983 Td
(son)Tj
1.6328 0 Td
(but)Tj
1.5534 0 Td
(rose)Tj
1.8822 0 Td
(again)Tj
2.3696 0 Td
(sharply)Tj
3.1351 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4684 0 Td
(beginning)Tj
4.2633 0 Td
(of)Tj
1.0148 0 Td
(each)Tj
2.0239 0 Td
(wet)Tj
1.6271 0 Td
(season)Tj
2.8573 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(2)Tj
0 g
(\).)Tj
1.2586 0 Td
(Mosquitoes)Tj
4.8755 0 Td
(were)Tj
2.1203 0 Td
(caught)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 129.8268 23.6976 re
W* n
q
129.7701 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 371.9622 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Spread)Tj
3.3874 0 Td
(of)Tj
1.0417 0 Td
(dengue-suppr)Tj
6.0591 0 Td
(essing)Tj
/F7 1 Tf
3.0544 0 Td
(Wolbachi)Tj
4.0394 0 Td
(a)Tj
/F0 1 Tf
0.7653 0 Td
(in)Tj
/F7 1 Tf
0.978 0 Td
(Aedes)Tj
3.0118 0 Td
(aegypti)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
90.1417 34.9228 m
243.8362 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Biology)Tj
3.437 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.pb)Tj
5.1236 0 Td
(io.2001894)Tj
0 g
5.8536 0 Td
(May)Tj
2.0835 0 Td
(30,)Tj
1.5874 0 Td
(2017)Tj
34.4908 0 Td
(4)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
171 0 obj
<>stream
endstream
endobj
172 0 obj
<>stream
endstream
endobj
173 0 obj
<>stream
endstream
endobj
174 0 obj
<>stream
endstream
endobj
175 0 obj
<>stream
endstream
endobj
176 0 obj
<>stream
endstream
endobj
177 0 obj
<>stream
endstream
endobj
178 0 obj
<>stream
endstream
endobj
179 0 obj
<>stream
endstream
endobj
180 0 obj
<>stream
endstream
endobj
181 0 obj
<>stream
endstream
endobj
182 0 obj
<>stream
endstream
endobj
183 0 obj
<>stream
BT
66.402 0 Td
(28)Tj
ET
Q
endstream
endobj
184 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 186 0 R/Contents 187 0 R/TrimBox[0 0 612 792]>>
endobj
185 0 obj
<>stream
xřnjZVU^mЮ6jsP @`@IHDw8ㄍm8&ƀ1`Ԕ473=gUo("("("("("("("("("("("("("("("("("("("("("("("("("("("("("("("(+c}n"("("("("("(B{yꩧ|ܸq"("("("("("(@zزe_W)KȳҊlI)*2)*_#%H%`wʾ#=(=UW\\\RR¿%*s<̥F6=~ .snqIfE o[)RGy:?<%RR\T@eOS!SE@oԪwmS]SSS4k֬k<~J[)ӎin-:+T.rJ/M֤;م@UUUccٳ+*w+++2e
'ܹsw剖JUMFm>de7o}Ą2Ϝ
SO?N&U7E *5:Zsssuuuz01S;Wya"d
'yMgyDnߑ"'&lz:Zn| FjZ?~FʩV3)#J )t"(@"0n@
O晎c=?-M'sJҲS:fN:_A"pHگ+3VVn[ez):)wc1aנJ!
F1iAXjkUg/^d 0&](#7wvv.Xܸ-ZDDqJ'JˮM:ƺCu_fҕhc#0wc`:Oދ"n268ۙgEz|q_imѝ,=,\:wI]]Wߨ+hR3n "牬?E@P