@article{20972,
  abstract     = {Small amounts of stress are thought to have beneficial effects. A new study reports a mechanism by which the psychedelic drug, psilocybin, causes acute release of stress hormones, despite its known long-term anti-anxiety effects.},
  author       = {Kücükdereli, Hakan and Douglass, Amelia May Barnett},
  issn         = {1879-0445},
  journal      = {Current Biology},
  number       = {1},
  pages        = {R27--R29},
  publisher    = {Elsevier},
  title        = {{Neuroscience: What doesn’t kill you makes you stronger}},
  doi          = {10.1016/j.cub.2025.11.056},
  volume       = {36},
  year         = {2026},
}

@article{21744,
  abstract     = {The paraventricular hypothalamus (PVH) controls behavioral and physiologic processes, including appetite, social behavior, autonomic outflow, and pituitary hormone secretion. However, molecular markers for centrally projecting PVH neuron populations remain largely undefined, and a complete census of PVH cell types has not been established. Therefore, we performed extensive single-cell/nucleus RNA sequencing to catalog PVH neuron subtypes and multiplexed error-robust fluorescence in situ hybridization (MERFISH) to map them spatially. Our spatial transcriptomic atlas resolves 26 Sim1+ and 29 GABAergic neuron populations from the PVH and surrounding areas. Additionally, projection-based profiling identified neurons that project to the parabrachial region (PB) and spinal cord, helping to determine PVH populations that regulate satiety and sympathetic nervous system activity, respectively. Notably, activation of PB-projecting PVH neurons expressing Brs3 reduces food intake, and silencing them causes obesity. Together, this atlas contributes high-resolution PVH spatial and circuit-based gene expression profiles, representing a valuable resource for the field of homeostasis.},
  author       = {Li, Yuxi and Butler, Trevor C. and Nardone, Stefano and Jacobs, Christopher L. and Douglass, Amelia May Barnett and Madara, Joseph C. and McDonough, Miriam C. and Tao, Jenkang and Lowenstein, Elijah D. and Wang, Luhong and Pant, Deepti and Walker, Samuel J. and Wang, Annette and Srinivasan, Harini and Yang, Zongfang and Campbell, John N. and Tsai, Linus T. and Lowell, Bradford B. and Resch, Jon M.},
  issn         = {2211-1247},
  journal      = {Cell Reports},
  number       = {2},
  publisher    = {Elsevier},
  title        = {{A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types}},
  doi          = {10.1016/j.celrep.2025.116904},
  volume       = {45},
  year         = {2026},
}

@article{21955,
  abstract     = {AgRP neurons cause hunger, the drive to seek and consume food. Their activation by fasting is key for survival and is thought to be triggered by feedback when energy stores are low. However, we know that environmental cues can also regulate AgRP neurons since cues that predict future food intake rapidly inhibit AgRP neurons, but is the converse true: can the prediction of future fasting rapidly activate AgRP neurons? Here, we show in mice that such rapid fasting activation of AgRP neurons does occur. This rapid activation is driven by excitatory input from paraventricular hypothalamic (PVH) neurons expressing Sim2, which are bidirectionally sensitive to predictions of future energy state. Thus, cognitively processed contextual information conveyed by PVHSim2 neurons strongly activates AgRP neurons. Lastly, chronic silencing of PVHSim2 neurons causes persistent hypophagia. This PVHSim2-to-AgRP-neuron circuit, by anticipating and preventing negative energy balance, provides an important new dimension of hunger regulation.},
  author       = {Walker, Samuel J. and Lowenstein, Elijah D. and Douglass, Amelia May Barnett and Thomas, Callum M.P. and Madara, Joseph C. and Kucukdereli, Hakan and Barbosa-Meillon, Eunice A. and Tao, Jenkang and Resch, Jon M. and Lowell, Bradford B.},
  issn         = { 1097-4199},
  journal      = {Neuron},
  keywords     = {hunger, hypothalamus, AGRP neurons, neuroscience, metabolism, homeostasis, feeding, food intake, energy balance, appetite},
  publisher    = {Elsevier},
  title        = {{A hypothalamic circuit for anticipating future changes in energy balance}},
  doi          = {10.1016/j.neuron.2026.05.010},
  year         = {2026},
}