[{"citation":{"chicago":"Kücükdereli, Hakan, and Amelia M. Douglass. “Neuroscience: What Doesn’t Kill You Makes You Stronger.” <i>Current Biology</i>. Elsevier, 2026. <a href=\"https://doi.org/10.1016/j.cub.2025.11.056\">https://doi.org/10.1016/j.cub.2025.11.056</a>.","apa":"Kücükdereli, H., &#38; Douglass, A. M. (2026). Neuroscience: What doesn’t kill you makes you stronger. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2025.11.056\">https://doi.org/10.1016/j.cub.2025.11.056</a>","ieee":"H. Kücükdereli and A. M. Douglass, “Neuroscience: What doesn’t kill you makes you stronger,” <i>Current Biology</i>, vol. 36, no. 1. Elsevier, pp. R27–R29, 2026.","mla":"Kücükdereli, Hakan, and Amelia M. Douglass. “Neuroscience: What Doesn’t Kill You Makes You Stronger.” <i>Current Biology</i>, vol. 36, no. 1, Elsevier, 2026, pp. R27–29, doi:<a href=\"https://doi.org/10.1016/j.cub.2025.11.056\">10.1016/j.cub.2025.11.056</a>.","ama":"Kücükdereli H, Douglass AM. Neuroscience: What doesn’t kill you makes you stronger. <i>Current Biology</i>. 2026;36(1):R27-R29. doi:<a href=\"https://doi.org/10.1016/j.cub.2025.11.056\">10.1016/j.cub.2025.11.056</a>","short":"H. Kücükdereli, A.M. Douglass, Current Biology 36 (2026) R27–R29.","ista":"Kücükdereli H, Douglass AM. 2026. Neuroscience: What doesn’t kill you makes you stronger. Current Biology. 36(1), R27–R29."},"year":"2026","corr_author":"1","type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"lang":"eng","text":"Small amounts of stress are thought to have beneficial effects. A new study reports a mechanism by which the psychedelic drug, psilocybin, causes acute release of stress hormones, despite its known long-term anti-anxiety effects."}],"pmid":1,"scopus_import":"1","doi":"10.1016/j.cub.2025.11.056","day":"05","page":"R27-R29","publication":"Current Biology","date_created":"2026-01-11T23:01:33Z","issue":"1","OA_type":"closed access","article_type":"letter_note","language":[{"iso":"eng"}],"_id":"20972","intvolume":"        36","author":[{"id":"5d5f6ea4-ef9e-11f0-a10a-85e12a3552af","last_name":"Kücükdereli","full_name":"Kücükdereli, Hakan","first_name":"Hakan"},{"last_name":"Douglass","id":"de5f6fda-80fb-11ef-996f-a8c4ecd8e289","first_name":"Amelia May Barnett","full_name":"Douglass, Amelia May Barnett","orcid":"0000-0001-5398-6473"}],"article_processing_charge":"No","publisher":"Elsevier","title":"Neuroscience: What doesn’t kill you makes you stronger","external_id":{"pmid":["41494523"]},"date_updated":"2026-01-12T10:09:13Z","oa_version":"None","department":[{"_id":"AmDo"},{"_id":"SiHi"}],"date_published":"2026-01-05T00:00:00Z","publication_identifier":{"eissn":["1879-0445"],"issn":["0960-9822"]},"quality_controlled":"1","status":"public","volume":36,"month":"01"},{"_id":"21744","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","file_date_updated":"2026-05-04T11:58:51Z","intvolume":"        45","author":[{"last_name":"Li","full_name":"Li, Yuxi","first_name":"Yuxi"},{"last_name":"Butler","first_name":"Trevor C.","full_name":"Butler, Trevor C."},{"last_name":"Nardone","first_name":"Stefano","full_name":"Nardone, Stefano"},{"first_name":"Christopher L.","full_name":"Jacobs, Christopher L.","last_name":"Jacobs"},{"last_name":"Douglass","id":"de5f6fda-80fb-11ef-996f-a8c4ecd8e289","first_name":"Amelia May Barnett","full_name":"Douglass, Amelia May Barnett","orcid":"0000-0001-5398-6473"},{"last_name":"Madara","full_name":"Madara, Joseph C.","first_name":"Joseph C."},{"full_name":"McDonough, Miriam C.","first_name":"Miriam C.","last_name":"McDonough"},{"full_name":"Tao, Jenkang","first_name":"Jenkang","last_name":"Tao"},{"first_name":"Elijah D.","full_name":"Lowenstein, Elijah D.","last_name":"Lowenstein"},{"first_name":"Luhong","full_name":"Wang, Luhong","last_name":"Wang"},{"last_name":"Pant","first_name":"Deepti","full_name":"Pant, Deepti"},{"last_name":"Walker","first_name":"Samuel J.","full_name":"Walker, Samuel J."},{"last_name":"Wang","full_name":"Wang, Annette","first_name":"Annette"},{"last_name":"Srinivasan","full_name":"Srinivasan, Harini","first_name":"Harini"},{"full_name":"Yang, Zongfang","first_name":"Zongfang","last_name":"Yang"},{"full_name":"Campbell, John N.","first_name":"John N.","last_name":"Campbell"},{"last_name":"Tsai","full_name":"Tsai, Linus T.","first_name":"Linus T."},{"last_name":"Lowell","full_name":"Lowell, Bradford B.","first_name":"Bradford B."},{"first_name":"Jon M.","full_name":"Resch, Jon M.","last_name":"Resch"}],"OA_type":"gold","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)"},"article_type":"original","language":[{"iso":"eng"}],"status":"public","quality_controlled":"1","DOAJ_listed":"1","acknowledgement":"We would like to thank Drs. Mark Andermann, Joel Geerling, and Clifford\r\nSaper, as well as the Lowell, Tsai, and Resch laboratories for helpful discussions;\r\nAlysia Berns, Jia Yu, and Yanfang Li for technical support; the BNORC\r\nFunctional Genomics and Bioinformatics Core (P30DK046200) and the Iowa\r\nInstitute for Human Genetics Genomics Division (IIHG, RRID: SCR_023422)\r\nfor helpful discussions and technical assistance with sc/snRNA-seq; Zachary\r\nNiziolek and the Bauer Core Facility at Harvard University, the BIDMC Flow Cytometry\r\nCore, and Heath Vignes, Michael Shey, and Thomas Kaufman of the\r\nFlow Cytometry Facility at the University of Iowa Carver College of Medicine\r\nfor helpful discussions and technical support; the ICCB-Longwood Screening\r\nFacility of Harvard Medical School for assistance with the snRNA-seq\r\nexperiments; Dr. Sayak Mitter and Vizgen support for technical assistance\r\nwith the MERSCOPE platform; and Mara Jendro and Li-Chun (Queena) Lin\r\nfor their assistance with MERSCOPE experiments within the Iowa\r\nNeuroBank Core in the Iowa Neuroscience Institute at the University of Iowa\r\nCarver College of Medicine. This research was funded by the following NIH\r\ngrants to L.T.T.: R01DK128406; to B.B.L.: R01DK075632, R01DK134427,\r\nand R01DK096010; to J.M.R.: R00HL144923 and R01NS141072; and to M.C.M.: F31HL170784; T.C.B. and M.C.M. were supported by a pharmacological\r\nsciences predoctoral training grant T32GM144636. Additional funding\r\nto J.M.R. came from the American Heart Association (AHA 935362), a University\r\nof Iowa Fraternal Order of Eagles Diabetes Research Center Pilot and\r\nFeasibility Catalyst Grant, and an Iowa Neuroscience Institute Early Stage\r\nInvestigator award from the Carver Trust. Y.L. was supported by a predoctoral\r\nfellowship from the American Heart Association (AHA 25PRE1372983). A.M.D.\r\nwas supported by a postdoctoral fellowship from the Charles A. King Trust.","volume":45,"month":"02","article_processing_charge":"Yes","title":"A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types","publisher":"Elsevier","external_id":{"pmid":["41581146"]},"date_updated":"2026-05-04T12:00:31Z","publication_status":"published","publication_identifier":{"eissn":["2211-1247"],"issn":["2639-1856"]},"date_published":"2026-02-24T00:00:00Z","department":[{"_id":"AmDo"}],"oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","has_accepted_license":"1","OA_place":"publisher","citation":{"ista":"Li Y, Butler TC, Nardone S, Jacobs CL, Douglass AM, Madara JC, McDonough MC, Tao J, Lowenstein ED, Wang L, Pant D, Walker SJ, Wang A, Srinivasan H, Yang Z, Campbell JN, Tsai LT, Lowell BB, Resch JM. 2026. A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types. Cell Reports. 45(2), 116904.","ama":"Li Y, Butler TC, Nardone S, et al. A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types. <i>Cell Reports</i>. 2026;45(2). doi:<a href=\"https://doi.org/10.1016/j.celrep.2025.116904\">10.1016/j.celrep.2025.116904</a>","short":"Y. Li, T.C. Butler, S. Nardone, C.L. Jacobs, A.M. Douglass, J.C. Madara, M.C. McDonough, J. Tao, E.D. Lowenstein, L. Wang, D. Pant, S.J. Walker, A. Wang, H. Srinivasan, Z. Yang, J.N. Campbell, L.T. Tsai, B.B. Lowell, J.M. Resch, Cell Reports 45 (2026).","ieee":"Y. Li <i>et al.</i>, “A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types,” <i>Cell Reports</i>, vol. 45, no. 2. Elsevier, 2026.","mla":"Li, Yuxi, et al. “A Spatial and Projection-Based Transcriptomic Atlas of Paraventricular Hypothalamic Cell Types.” <i>Cell Reports</i>, vol. 45, no. 2, 116904, Elsevier, 2026, doi:<a href=\"https://doi.org/10.1016/j.celrep.2025.116904\">10.1016/j.celrep.2025.116904</a>.","apa":"Li, Y., Butler, T. C., Nardone, S., Jacobs, C. L., Douglass, A. M., Madara, J. C., … Resch, J. M. (2026). A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types. <i>Cell Reports</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.celrep.2025.116904\">https://doi.org/10.1016/j.celrep.2025.116904</a>","chicago":"Li, Yuxi, Trevor C. Butler, Stefano Nardone, Christopher L. Jacobs, Amelia M. Douglass, Joseph C. Madara, Miriam C. McDonough, et al. “A Spatial and Projection-Based Transcriptomic Atlas of Paraventricular Hypothalamic Cell Types.” <i>Cell Reports</i>. Elsevier, 2026. <a href=\"https://doi.org/10.1016/j.celrep.2025.116904\">https://doi.org/10.1016/j.celrep.2025.116904</a>."},"type":"journal_article","year":"2026","article_number":"116904","file":[{"date_updated":"2026-05-04T11:58:51Z","success":1,"file_name":"2026_CellReports_Li.pdf","content_type":"application/pdf","file_id":"21793","date_created":"2026-05-04T11:58:51Z","file_size":38532865,"checksum":"82098dd9d0ca609119f9f2c6beb4fc1e","access_level":"open_access","relation":"main_file","creator":"dernst"}],"publication":"Cell Reports","date_created":"2026-04-16T13:51:29Z","issue":"2","ddc":["570"],"abstract":[{"text":"The paraventricular hypothalamus (PVH) controls behavioral and physiologic processes, including appetite, social behavior, autonomic outflow, and pituitary hormone secretion. However, molecular markers for centrally projecting PVH neuron populations remain largely undefined, and a complete census of PVH cell types has not been established. Therefore, we performed extensive single-cell/nucleus RNA sequencing to catalog PVH neuron subtypes and multiplexed error-robust fluorescence in situ hybridization (MERFISH) to map them spatially. Our spatial transcriptomic atlas resolves 26 Sim1+ and 29 GABAergic neuron populations from the PVH and surrounding areas. Additionally, projection-based profiling identified neurons that project to the parabrachial region (PB) and spinal cord, helping to determine PVH populations that regulate satiety and sympathetic nervous system activity, respectively. Notably, activation of PB-projecting PVH neurons expressing Brs3 reduces food intake, and silencing them causes obesity. Together, this atlas contributes high-resolution PVH spatial and circuit-based gene expression profiles, representing a valuable resource for the field of homeostasis.","lang":"eng"}],"pmid":1,"oa":1,"doi":"10.1016/j.celrep.2025.116904","scopus_import":"1","day":"24"},{"scopus_import":"1","doi":"10.1016/j.neuron.2026.05.010","oa":1,"day":"03","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2025.09.27.678865"}],"abstract":[{"lang":"eng","text":"AgRP neurons cause hunger, the drive to seek and consume food. Their activation by fasting is key for survival and is thought to be triggered by feedback when energy stores are low. However, we know that environmental cues can also regulate AgRP neurons since cues that predict future food intake rapidly inhibit AgRP neurons, but is the converse true: can the prediction of future fasting rapidly activate AgRP neurons? Here, we show in mice that such rapid fasting activation of AgRP neurons does occur. This rapid activation is driven by excitatory input from paraventricular hypothalamic (PVH) neurons expressing Sim2, which are bidirectionally sensitive to predictions of future energy state. Thus, cognitively processed contextual information conveyed by PVHSim2 neurons strongly activates AgRP neurons. Lastly, chronic silencing of PVHSim2 neurons causes persistent hypophagia. This PVHSim2-to-AgRP-neuron circuit, by anticipating and preventing negative energy balance, provides an important new dimension of hunger regulation."}],"pmid":1,"date_created":"2026-06-08T09:24:25Z","publication":"Neuron","year":"2026","type":"journal_article","citation":{"apa":"Walker, S. J., Lowenstein, E. D., Douglass, A. M., Thomas, C. M. P., Madara, J. C., Kucukdereli, H., … Lowell, B. B. (n.d.). A hypothalamic circuit for anticipating future changes in energy balance. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2026.05.010\">https://doi.org/10.1016/j.neuron.2026.05.010</a>","chicago":"Walker, Samuel J., Elijah D. Lowenstein, Amelia M. Douglass, Callum M.P. Thomas, Joseph C. Madara, Hakan Kucukdereli, Eunice A. Barbosa-Meillon, Jenkang Tao, Jon M. Resch, and Bradford B. Lowell. “A Hypothalamic Circuit for Anticipating Future Changes in Energy Balance.” <i>Neuron</i>. Elsevier, n.d. <a href=\"https://doi.org/10.1016/j.neuron.2026.05.010\">https://doi.org/10.1016/j.neuron.2026.05.010</a>.","mla":"Walker, Samuel J., et al. “A Hypothalamic Circuit for Anticipating Future Changes in Energy Balance.” <i>Neuron</i>, Elsevier, doi:<a href=\"https://doi.org/10.1016/j.neuron.2026.05.010\">10.1016/j.neuron.2026.05.010</a>.","ieee":"S. J. Walker <i>et al.</i>, “A hypothalamic circuit for anticipating future changes in energy balance,” <i>Neuron</i>. Elsevier.","ama":"Walker SJ, Lowenstein ED, Douglass AM, et al. A hypothalamic circuit for anticipating future changes in energy balance. <i>Neuron</i>. doi:<a href=\"https://doi.org/10.1016/j.neuron.2026.05.010\">10.1016/j.neuron.2026.05.010</a>","short":"S.J. Walker, E.D. Lowenstein, A.M. Douglass, C.M.P. Thomas, J.C. Madara, H. Kucukdereli, E.A. Barbosa-Meillon, J. Tao, J.M. Resch, B.B. Lowell, Neuron (n.d.).","ista":"Walker SJ, Lowenstein ED, Douglass AM, Thomas CMP, Madara JC, Kucukdereli H, Barbosa-Meillon EA, Tao J, Resch JM, Lowell BB. A hypothalamic circuit for anticipating future changes in energy balance. Neuron."},"OA_place":"repository","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","keyword":["hunger","hypothalamus","AGRP neurons","neuroscience","metabolism","homeostasis","feeding","food intake","energy balance","appetite"],"publication_status":"inpress","date_updated":"2026-06-16T08:35:11Z","external_id":{"pmid":["42235510"]},"oa_version":"Preprint","department":[{"_id":"AmDo"}],"date_published":"2026-06-03T00:00:00Z","publication_identifier":{"eissn":[" 1097-4199"],"issn":["0896-6273"]},"article_processing_charge":"No","publisher":"Elsevier","title":"A hypothalamic circuit for anticipating future changes in energy balance","month":"06","quality_controlled":"1","status":"public","acknowledgement":"We thank all members of the B.B.L. laboratory for helpful discussions. We\r\nthank the BADERC and BNORC transgenic cores (NIH P30DK057521 and\r\nP30DK046200) for performing embryo injections to generate knockin mouse\r\nlines. We also thank the BIDMC Energy Balance Core (supported by NIH\r\nS10OD028635 and the Boston Area Diabetes Endocrinology Research Centers, P30DK135043), where Marissa Cortopassi performed indirect calorimetry experiments and Alexander Banks assisted with data analysis and interpretation. Confocal imaging was performed at BIDMC’s Confocal Imaging\r\nCore. We thank Chen Wu for assistance in designing knockin mouse lines.\r\nThis work was supported by the NIH (R01DK134427, R01DK096010, and\r\nR01DK075632 to B.B.L.). Authors were supported by an EMBO Long-Term\r\nFellowship (770-2018, S.J.W.), a T32 Postdoctoral Training Fellowship\r\n(5T32DK007516, E.D.L.), the Charles A. King Trust Postdoctoral Research\r\nFellowship program (A.M.D.), and a K99 Career Development Award\r\n(K99HL144923, J.M.R.).","article_type":"original","OA_type":"green","language":[{"iso":"eng"}],"author":[{"last_name":"Walker","first_name":"Samuel J.","full_name":"Walker, Samuel J."},{"full_name":"Lowenstein, Elijah D.","first_name":"Elijah D.","last_name":"Lowenstein"},{"last_name":"Douglass","id":"de5f6fda-80fb-11ef-996f-a8c4ecd8e289","first_name":"Amelia May Barnett","full_name":"Douglass, Amelia May Barnett","orcid":"0000-0001-5398-6473"},{"full_name":"Thomas, Callum M.P.","first_name":"Callum M.P.","last_name":"Thomas"},{"last_name":"Madara","first_name":"Joseph C.","full_name":"Madara, Joseph C."},{"last_name":"Kucukdereli","full_name":"Kucukdereli, Hakan","first_name":"Hakan"},{"first_name":"Eunice A.","full_name":"Barbosa-Meillon, Eunice A.","last_name":"Barbosa-Meillon"},{"last_name":"Tao","full_name":"Tao, Jenkang","first_name":"Jenkang"},{"first_name":"Jon M.","full_name":"Resch, Jon M.","last_name":"Resch"},{"last_name":"Lowell","first_name":"Bradford B.","full_name":"Lowell, Bradford B."}],"_id":"21955"}]