---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21748'
abstract:
- lang: eng
text: Cells are defined by lipid membranes that differ in their structure across
the tree of life. While the membranes of most bacteria and eukaryotes consist
of single-headed bilayer lipids, the membranes of archaea are composed of mixtures
of single-headed bilayer lipids and double-headed bolalipids. Archaeal bolalipids
can adopt straight or u-shaped conformations, enabling them—together with bilayer
lipids—to control whether membranes form bilayer or monolayer structures. Yet,
the physical principles governing archaeal membranes remain largely unexplored,
especially how membrane structure couples to externally imposed curvature during
membrane remodeling. Here, we perform coarse-grained molecular dynamics simulations
of toroidal vesicles to systematically probe the effects of all relevant combinations
of mean and Gaussian curvatures on shape stability and lipid organization. We
find that soft bilayer membranes can sustain all curvatures induced, whereas rigid
bolalipid monolayer membranes either transition to different vesicle shapes or
rupture. Bilayer-mimicking u-shaped bolalipids and bilayer lipids are spatially
accumulated in regions of high mean membrane curvature independent of Gaussian
curvature. Our work identifies curvature–composition coupling as a physical signature
of archaeal membrane remodeling.
acknowledgement: F.F. acknowledges the financial support from the NOMIS foundation.
M.A. and A.Š. acknowledge the funding from the Volkswagen Foundation (Grant No.
Az 96727). A.Š. acknowledges the funding from ERC Starting Grant “NEPA” (Grant No.
802960) and the Vallee Scholarship.
article_number: '144902'
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
- first_name: Felix F
full_name: Frey, Felix F
id: a0270b37-8f1a-11ec-95c7-8e710c59a4f3
last_name: Frey
orcid: 0000-0001-8501-6017
- first_name: Miguel
full_name: Santana de Freitas Amaral, Miguel
id: 4f2d02dd-47a9-11ec-ad10-82820ed3f501
last_name: Santana de Freitas Amaral
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
citation:
ama: 'Frey FF, Santana de Freitas Amaral M, Šarić A. Cracking donuts and sorting
lipids: Geometry controls archaeal membrane stability and lipid organization.
Journal of Chemical Physics. 2026;164(14). doi:10.1063/5.0325170'
apa: 'Frey, F. F., Santana de Freitas Amaral, M., & Šarić, A. (2026). Cracking
donuts and sorting lipids: Geometry controls archaeal membrane stability and lipid
organization. Journal of Chemical Physics. AIP Publishing. https://doi.org/10.1063/5.0325170'
chicago: 'Frey, Felix F, Miguel Santana de Freitas Amaral, and Anđela Šarić. “Cracking
Donuts and Sorting Lipids: Geometry Controls Archaeal Membrane Stability and Lipid
Organization.” Journal of Chemical Physics. AIP Publishing, 2026. https://doi.org/10.1063/5.0325170.'
ieee: 'F. F. Frey, M. Santana de Freitas Amaral, and A. Šarić, “Cracking donuts
and sorting lipids: Geometry controls archaeal membrane stability and lipid organization,”
Journal of Chemical Physics, vol. 164, no. 14. AIP Publishing, 2026.'
ista: 'Frey FF, Santana de Freitas Amaral M, Šarić A. 2026. Cracking donuts and
sorting lipids: Geometry controls archaeal membrane stability and lipid organization.
Journal of Chemical Physics. 164(14), 144902.'
mla: 'Frey, Felix F., et al. “Cracking Donuts and Sorting Lipids: Geometry Controls
Archaeal Membrane Stability and Lipid Organization.” Journal of Chemical Physics,
vol. 164, no. 14, 144902, AIP Publishing, 2026, doi:10.1063/5.0325170.'
short: F.F. Frey, M. Santana de Freitas Amaral, A. Šarić, Journal of Chemical Physics
164 (2026).
corr_author: '1'
date_created: 2026-04-19T22:07:45Z
date_published: 2026-04-14T00:00:00Z
date_updated: 2026-05-05T12:40:41Z
day: '14'
ddc:
- '540'
department:
- _id: AnSa
doi: 10.1063/5.0325170
ec_funded: 1
external_id:
arxiv:
- '2603.15170'
file:
- access_level: open_access
checksum: 2e10c4f4531676e0771ef3730e4b63a9
content_type: application/pdf
creator: dernst
date_created: 2026-05-05T12:35:24Z
date_updated: 2026-05-05T12:35:24Z
file_id: '21801'
file_name: 2026_JourChemPhysics_Frey.pdf
file_size: 8764791
relation: main_file
success: 1
file_date_updated: 2026-05-05T12:35:24Z
has_accepted_license: '1'
intvolume: ' 164'
issue: '14'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
call_identifier: H2020
grant_number: '802960'
name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
publication: Journal of Chemical Physics
publication_identifier:
eissn:
- 1089-7690
issn:
- ' 0021-9606'
publication_status: published
publisher: AIP Publishing
quality_controlled: '1'
related_material:
record:
- id: '21800'
relation: research_data
status: public
scopus_import: '1'
status: public
title: 'Cracking donuts and sorting lipids: Geometry controls archaeal membrane stability
and lipid organization'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 164
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21749'
abstract:
- lang: eng
text: The collagen triple helix assembles hierarchically into bundled oligomers,
solvated networks, and fibers. Synthetic peptide assemblies, driven by supramolecular
interactions, can form single triple helices through intrahelical amino acid pairs;
however, the principles guiding interhelical associations into higher-order structures
remain unclear. Here, we incorporate cation−π and electrostatic charge pairs to
probe interhelical interactions and elucidate the mechanisms driving triple helix
assembly into fibrils, nanotubes, and nanosheets. Introducing cation−π pairs into
a fibrillating collagen mimetic resulted in D-periodic fibrils with pH-sensitive
gelation. By alternating the presentation of electrostatic and cation−π pairs,
the assembly of another D-periodic fibril featuring inner and outer triple-helical
layers was resolved by cryo electron microscopy to a resolution of 8 Å. At physiological
pH, antiparallel association of these triple helices leads to the formation of
nanotubes. The packing behavior of triple helices correlates with the interhelical
interactions, where parallel associations favor fibril formation and antiparallel
interactions drive nanotube and nanosheet assembly. These self-assembling triple-helical
peptides demonstrate how packing of higher-order structures can be tailored with
supramolecular interactions and establish the relationship of different hierarchical
collagen-mimetic assemblies as pH-dependent.
acknowledgement: The authors acknowledge Crispin Hetherington and L. Tracy Yu for
their technical assistance and insights. This work was funded in part by the National
Science Foundation (CHE 2203937), the National Science Foundation Graduate Research
Fellowship (Grant No. 1842494), the Welch Foundation (C-2141), the Swedish Research
Council (2020-04633), and the NIH (GM122510). This work benefited from using the
SasView application, originally developed under NSF award DMR-0520547. SasView contains
code developed with funding from the European Union’s Horizon 2020 research and
innovation program under the SINE2020 project, Grant Agreement No. 654000. This
work was partly done using the Shared Equipment Authority resources at Rice University.
article_processing_charge: No
article_type: original
author:
- first_name: Carson C.
full_name: Cole, Carson C.
last_name: Cole
- first_name: Mark A.B.
full_name: Kreutzberger, Mark A.B.
last_name: Kreutzberger
- first_name: Kevin
full_name: Klein, Kevin
id: 1e7ede04-9e54-11f0-9ec4-8d4d5563c398
last_name: Klein
- first_name: Kiana A.
full_name: Cahue, Kiana A.
last_name: Cahue
- first_name: Brett H.
full_name: Pogostin, Brett H.
last_name: Pogostin
- first_name: Adam C.
full_name: Farsheed, Adam C.
last_name: Farsheed
- first_name: Joseph W.R.
full_name: Swain, Joseph W.R.
last_name: Swain
- first_name: Thi H.
full_name: Bui, Thi H.
last_name: Bui
- first_name: Arghadip
full_name: Dey, Arghadip
last_name: Dey
- first_name: Jonathan T.
full_name: Makhoul, Jonathan T.
last_name: Makhoul
- first_name: Marija
full_name: Dubackic, Marija
last_name: Dubackic
- first_name: Antara
full_name: Pal, Antara
last_name: Pal
- first_name: Ulf
full_name: Olsson, Ulf
last_name: Olsson
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Edward H.
full_name: Egelman, Edward H.
last_name: Egelman
- first_name: Jeffrey D.
full_name: Hartgerink, Jeffrey D.
last_name: Hartgerink
citation:
ama: Cole CC, Kreutzberger MAB, Klein K, et al. Supramolecular assembly of collagen-mimetic
eptide D-periodic fibrils and nanoassemblies. Biomacromolecules. 2026;27(4):2956-2965.
doi:10.1021/acs.biomac.6c00345
apa: Cole, C. C., Kreutzberger, M. A. B., Klein, K., Cahue, K. A., Pogostin, B.
H., Farsheed, A. C., … Hartgerink, J. D. (2026). Supramolecular assembly of collagen-mimetic
eptide D-periodic fibrils and nanoassemblies. Biomacromolecules. American
Chemical Society. https://doi.org/10.1021/acs.biomac.6c00345
chicago: Cole, Carson C., Mark A.B. Kreutzberger, Kevin Klein, Kiana A. Cahue, Brett
H. Pogostin, Adam C. Farsheed, Joseph W.R. Swain, et al. “Supramolecular Assembly
of Collagen-Mimetic Eptide D-Periodic Fibrils and Nanoassemblies.” Biomacromolecules.
American Chemical Society, 2026. https://doi.org/10.1021/acs.biomac.6c00345.
ieee: C. C. Cole et al., “Supramolecular assembly of collagen-mimetic eptide
D-periodic fibrils and nanoassemblies,” Biomacromolecules, vol. 27, no.
4. American Chemical Society, pp. 2956–2965, 2026.
ista: Cole CC, Kreutzberger MAB, Klein K, Cahue KA, Pogostin BH, Farsheed AC, Swain
JWR, Bui TH, Dey A, Makhoul JT, Dubackic M, Pal A, Olsson U, Šarić A, Egelman
EH, Hartgerink JD. 2026. Supramolecular assembly of collagen-mimetic eptide D-periodic
fibrils and nanoassemblies. Biomacromolecules. 27(4), 2956–2965.
mla: Cole, Carson C., et al. “Supramolecular Assembly of Collagen-Mimetic Eptide
D-Periodic Fibrils and Nanoassemblies.” Biomacromolecules, vol. 27, no.
4, American Chemical Society, 2026, pp. 2956–65, doi:10.1021/acs.biomac.6c00345.
short: C.C. Cole, M.A.B. Kreutzberger, K. Klein, K.A. Cahue, B.H. Pogostin, A.C.
Farsheed, J.W.R. Swain, T.H. Bui, A. Dey, J.T. Makhoul, M. Dubackic, A. Pal, U.
Olsson, A. Šarić, E.H. Egelman, J.D. Hartgerink, Biomacromolecules 27 (2026) 2956–2965.
date_created: 2026-04-19T22:07:46Z
date_published: 2026-04-13T00:00:00Z
date_updated: 2026-05-06T05:43:44Z
day: '13'
department:
- _id: AnSa
doi: 10.1021/acs.biomac.6c00345
intvolume: ' 27'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2025.02.15.637692
month: '04'
oa: 1
oa_version: Preprint
page: 2956-2965
publication: Biomacromolecules
publication_identifier:
eissn:
- 1526-4602
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Supramolecular assembly of collagen-mimetic eptide D-periodic fibrils and nanoassemblies
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 27
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21761'
abstract:
- lang: eng
text: Neural tube closure is a critical morphogenetic process in vertebrate development,
and failure to close cranial regions such as the hindbrain neuropore (HNP) leads
to severe congenital malformations. While mechanical forces such as actomyosin
purse-string contraction and directional cell crawling have been implicated in
driving HNP closure, how these forces organize local cell shape and motion to
produce large-scale tissue remodeling remains poorly understood. Using live and
fixed imaging of mouse embryos combined with cell-based biophysical modeling,
we show that these force-generating mechanisms are insufficient to explain the
reproducible patterns of cell elongation and nematic alignment observed at the
HNP border. Instead, we show that local anisotropic stress and cytoskeletal organization
are required to generate these patterns and promote midline cell motion. Our model
captures key features of cell shape dynamics and emergent nematic order, which
we confirm experimentally, including the alignment of actin fibers with cell shape
and enhanced midline cell speed. Comparative analysis with chick embryos, which
lack supracellular purse strings, supports a conserved link between tension generation
and cellular patterning. These findings establish a physical framework connecting
force generation, cell shape anisotropy, and tissue morphodynamics during epithelial
gap closure.
acknowledgement: S.B. acknowledges support from the National Institutes of Health
(NIH R35 GM143042) and the National Science Foundation (NSF MCB-2203601). G.L.G.
acknowledges support from the Wellcome Trust (211112/Z/18/Z), the Royal Society
(RG\R2\232082), and the Leverhulme Trust (RPG-2024-147). E.M. acknowledges support
from European Union’s Horizon 2021 Marie Sklodowska-Curie grant agreement no. 101067028.
F.P.-V. acknowledges support from the NOMIS foundation. The surface subtraction
macro is courtesy of Dr. Dale Moulding and available on GitHub (https://github.com/DaleMoulding/Fiji-Macros).
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Fernanda L
full_name: Perez Verdugo, Fernanda L
id: 4ecec223-9070-11ef-a0a9-bc76077bea8d
last_name: Perez Verdugo
- first_name: Eirini
full_name: Maniou, Eirini
last_name: Maniou
- first_name: Gabriel L.
full_name: Galea, Gabriel L.
last_name: Galea
- first_name: Shiladitya
full_name: Banerjee, Shiladitya
last_name: Banerjee
citation:
ama: Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. Mechanosensitive feedback
organizes cell shape and motion during hindbrain neuropore morphogenesis. Current
Biology. 2026;36(8):1903-1917.e5. doi:10.1016/j.cub.2026.02.068
apa: Perez Verdugo, F. L., Maniou, E., Galea, G. L., & Banerjee, S. (2026).
Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore
morphogenesis. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2026.02.068
chicago: Perez Verdugo, Fernanda L, Eirini Maniou, Gabriel L. Galea, and Shiladitya
Banerjee. “Mechanosensitive Feedback Organizes Cell Shape and Motion during Hindbrain
Neuropore Morphogenesis.” Current Biology. Elsevier, 2026. https://doi.org/10.1016/j.cub.2026.02.068.
ieee: F. L. Perez Verdugo, E. Maniou, G. L. Galea, and S. Banerjee, “Mechanosensitive
feedback organizes cell shape and motion during hindbrain neuropore morphogenesis,”
Current Biology, vol. 36, no. 8. Elsevier, p. 1903–1917.e5, 2026.
ista: Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. 2026. Mechanosensitive feedback
organizes cell shape and motion during hindbrain neuropore morphogenesis. Current
Biology. 36(8), 1903–1917.e5.
mla: Perez Verdugo, Fernanda L., et al. “Mechanosensitive Feedback Organizes Cell
Shape and Motion during Hindbrain Neuropore Morphogenesis.” Current Biology,
vol. 36, no. 8, Elsevier, 2026, p. 1903–1917.e5, doi:10.1016/j.cub.2026.02.068.
short: F.L. Perez Verdugo, E. Maniou, G.L. Galea, S. Banerjee, Current Biology 36
(2026) 1903–1917.e5.
date_created: 2026-04-26T22:01:46Z
date_published: 2026-04-20T00:00:00Z
date_updated: 2026-04-28T13:15:42Z
day: '20'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1016/j.cub.2026.02.068
external_id:
pmid:
- '41881011'
file:
- access_level: open_access
checksum: 80ae45457b4682c50c84f54de15aa9a8
content_type: application/pdf
creator: dernst
date_created: 2026-04-28T13:13:40Z
date_updated: 2026-04-28T13:13:40Z
file_id: '21774'
file_name: 2026_CurrentBiology_PerezVerdugo.pdf
file_size: 13402043
relation: main_file
success: 1
file_date_updated: 2026-04-28T13:13:40Z
has_accepted_license: '1'
intvolume: ' 36'
issue: '8'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 1903-1917.e5
pmid: 1
publication: Current Biology
publication_identifier:
eissn:
- 1879-0445
issn:
- 0960-9822
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanosensitive feedback organizes cell shape and motion during hindbrain
neuropore morphogenesis
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 36
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21764'
abstract:
- lang: eng
text: "Colloidal fluids can exhibit complex phase behavior and determining phase
diagrams via experiments or computer simulations can be laborious. We demonstrate
that the dispersion relation ω(k), obtained from dynamical density functional
theory for the uniform density system, is a highly versatile tool for predicting
where in the phase diagram complex crystals form. The sign of ω(k) determines
whether density modes with wave number k grow or decay over time. We demonstrate
the predictive power by investigating the complex phase behavior of particles
interacting via core-shoulder pair potentials. With complementary Monte Carlo
simulations, we show that regions of the phase diagram where ωðkÞ has one or several
unstable (growing) wave numbers are also where crystalline phases occur. Going
further, by tuning these\r\nunstable wave numbers via the interaction-potential
and state-point parameters, we design systems with quasicrystals in the phase
diagram. We identify a system with a certain shoulder range exhibiting at least
ten different phases. Our general approach accelerates considerably the mapping
of complex phase diagrams, crucial for the design of new materials."
acknowledgement: "The authors thank Ms. Katrin Muck for her guidance related to the
use of HPC. The MC\r\ncomputer simulation results presented here were enabled via
a generous share of CPU time, offered by the Vienna Scientific Cluster (VSC) under
Project No. 71263. A. J. A. gratefully acknowledges support from the EPSRC under
Grant No. EP/P015689/1. This research was funded in part by the Austrian Science
Fund (FWF) [Grant DOI: 10.55776/PIN8759524], gratefully acknowledged by G. K ."
article_number: '148203'
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
- first_name: Michael
full_name: Wassermair, Michael
id: 23d132c4-4e98-11ef-b275-9e8d4cd8c917
last_name: Wassermair
orcid: 0009-0003-6339-4051
- first_name: Gerhard
full_name: Kahl, Gerhard
last_name: Kahl
- first_name: Roland
full_name: Roth, Roland
last_name: Roth
- first_name: Andrew J.
full_name: Archer, Andrew J.
last_name: Archer
citation:
ama: Wassermair M, Kahl G, Roth R, Archer AJ. Navigating complex phase diagrams
in soft matter systems. Physical Review Letters. 2026;136(14). doi:10.1103/nbvt-fgjy
apa: Wassermair, M., Kahl, G., Roth, R., & Archer, A. J. (2026). Navigating
complex phase diagrams in soft matter systems. Physical Review Letters.
American Physical Society. https://doi.org/10.1103/nbvt-fgjy
chicago: Wassermair, Michael, Gerhard Kahl, Roland Roth, and Andrew J. Archer. “Navigating
Complex Phase Diagrams in Soft Matter Systems.” Physical Review Letters.
American Physical Society, 2026. https://doi.org/10.1103/nbvt-fgjy.
ieee: M. Wassermair, G. Kahl, R. Roth, and A. J. Archer, “Navigating complex phase
diagrams in soft matter systems,” Physical Review Letters, vol. 136, no.
14. American Physical Society, 2026.
ista: Wassermair M, Kahl G, Roth R, Archer AJ. 2026. Navigating complex phase diagrams
in soft matter systems. Physical Review Letters. 136(14), 148203.
mla: Wassermair, Michael, et al. “Navigating Complex Phase Diagrams in Soft Matter
Systems.” Physical Review Letters, vol. 136, no. 14, 148203, American Physical
Society, 2026, doi:10.1103/nbvt-fgjy.
short: M. Wassermair, G. Kahl, R. Roth, A.J. Archer, Physical Review Letters 136
(2026).
date_created: 2026-04-26T22:01:47Z
date_published: 2026-04-10T00:00:00Z
date_updated: 2026-04-28T07:03:48Z
day: '10'
ddc:
- '530'
department:
- _id: AnSa
- _id: GradSch
doi: 10.1103/nbvt-fgjy
external_id:
arxiv:
- '2603.18918'
file:
- access_level: open_access
checksum: 8ffb139122a185fcddbe6a9c901a287c
content_type: application/pdf
creator: dernst
date_created: 2026-04-28T06:58:40Z
date_updated: 2026-04-28T06:58:40Z
file_id: '21769'
file_name: 2026_PhysicalReviewLetters_Wassermair.pdf
file_size: 4336488
relation: main_file
success: 1
file_date_updated: 2026-04-28T06:58:40Z
has_accepted_license: '1'
intvolume: ' 136'
issue: '14'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
publication: Physical Review Letters
publication_identifier:
eissn:
- 1079-7114
issn:
- 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Navigating complex phase diagrams in soft matter systems
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 136
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21800'
abstract:
- lang: eng
text: 'LAMMPS input scripts to simulate toroidal vesicles composed of pure bolalipid
membranes and archaeal mixture membranes for the following publication: "Cracking
donuts and sorting lipids: geometry controls archaeal membrane stability and lipid
organization" by Felix Frey, Miguel Amaral, and Andela Saric.'
article_processing_charge: No
author:
- first_name: Felix F
full_name: Frey, Felix F
id: a0270b37-8f1a-11ec-95c7-8e710c59a4f3
last_name: Frey
orcid: 0000-0001-8501-6017
- first_name: Miguel
full_name: Santana de Freitas Amaral, Miguel
id: 4f2d02dd-47a9-11ec-ad10-82820ed3f501
last_name: Santana de Freitas Amaral
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
citation:
ama: 'Frey FF, Santana de Freitas Amaral M, Šarić A. Cracking donuts and sorting
lipids: Geometry controls archaeal membrane stability and lipid organization.
2026. doi:10.5281/ZENODO.18772086'
apa: 'Frey, F. F., Santana de Freitas Amaral, M., & Šarić, A. (2026). Cracking
donuts and sorting lipids: Geometry controls archaeal membrane stability and lipid
organization. Zenodo. https://doi.org/10.5281/ZENODO.18772086'
chicago: 'Frey, Felix F, Miguel Santana de Freitas Amaral, and Anđela Šarić. “Cracking
Donuts and Sorting Lipids: Geometry Controls Archaeal Membrane Stability and Lipid
Organization.” Zenodo, 2026. https://doi.org/10.5281/ZENODO.18772086.'
ieee: 'F. F. Frey, M. Santana de Freitas Amaral, and A. Šarić, “Cracking donuts
and sorting lipids: Geometry controls archaeal membrane stability and lipid organization.”
Zenodo, 2026.'
ista: 'Frey FF, Santana de Freitas Amaral M, Šarić A. 2026. Cracking donuts and
sorting lipids: Geometry controls archaeal membrane stability and lipid organization,
Zenodo, 10.5281/ZENODO.18772086.'
mla: 'Frey, Felix F., et al. Cracking Donuts and Sorting Lipids: Geometry Controls
Archaeal Membrane Stability and Lipid Organization. Zenodo, 2026, doi:10.5281/ZENODO.18772086.'
short: F.F. Frey, M. Santana de Freitas Amaral, A. Šarić, (2026).
corr_author: '1'
date_created: 2026-05-05T12:11:52Z
date_published: 2026-02-25T00:00:00Z
date_updated: 2026-05-05T12:40:41Z
day: '25'
ddc:
- '540'
department:
- _id: AnSa
doi: 10.5281/ZENODO.18772086
main_file_link:
- open_access: '1'
url: https://doi.org/10.5281/ZENODO.18772086
month: '02'
oa: 1
oa_version: Published Version
publisher: Zenodo
related_material:
record:
- id: '21748'
relation: used_in_publication
status: public
status: public
title: 'Cracking donuts and sorting lipids: Geometry controls archaeal membrane stability
and lipid organization'
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21369'
abstract:
- lang: eng
text: 'Formation of new amyloid fibrils and oligomers from monomeric protein on
the surfaces of existing fibrils is an important driver of many disorders such
as Alzheimer’s and Parkinson’s diseases. The structural basis of this secondary
nucleation process, however, is poorly understood. Here, we ask whether secondary
nucleation sites are found predominantly at rare growth defects: irregularities
in the fibril core structure incorporated during their original assembly. We first
demonstrate using the specific inhibitor of secondary nucleation, Brichos, that
secondary nucleation sites on Alzheimer’s disease-associated fibrils composed
of Aβ40 and Aβ42 peptides are rare compared to the number of protein molecules
they contain. We then grow Aβ40 fibrils under conditions designed to eliminate
most growth defects while leaving the regular fibril morphology unchanged, and
confirm the latter using cryo-electron microscopy. We measure both the ability
of these annealed fibrils to promote secondary nucleation and the stoichiometry
of their secondary nucleation sites, finding that both are greatly reduced as
predicted. Re-analysis of published data for other proteins suggests that fibril
growth defects may also drive secondary nucleation generally across most amyloids.
These findings could unlock structure-based drug design of therapeutics that aim
to halt amyloid disorders by inhibiting secondary nucleation sites.'
acknowledgement: This work was supported by the Swedish Research Council (2019-02397
to E.S., 2015-00143 to S.L., and 2022-06641 to S.L. and E.S.), and the GenerationNano
project, the European Union’s Horizon 2020 research and innovation programme under
the Marie Skłodowska-Curie grant agreement No 945378 (S.L. co-PI). We acknowledge
support from the Wellcome Trust (T.P.J.K.), the Cambridge Centre for Misfolding
Diseases (T.P.J.K.), the BBSRC (T.P.J.K.), the Frances and Augustus Newman Foundation
(T.P.J.K.), the ERC PhysProt (agreement n 337969) (T.S., T.P.J.K., S.L.), ETC StG
“NEPA” (A.Š. and S.C.), the Royal Society (S.C., A.S.), the ERASMUS Programme (T.S.),
and The Danish Council for Independent Research ∣ Natural Sciences (FNU-11-113326)
(M.A.). This work was also funded by the Novo Nordisk Foundation (#NNF19OC0054635
to S.L.), ETH Zürich (T.C.T.M.), and the Swiss National Science Foundation (grant
no 219703 to A.J.D. and T.C.T.M.). We acknowledge the use of the nano-Characterisation
and nano-Manufacturing Research Equipment (nCHREM) facility for access to microscopy
instrumentation. We are grateful to the late Professor Sir Christopher Dobson for
invaluable conversations regarding the microfluidic diffusional sizing experiments.
We are also grateful to Quentin A. E. Peter and Thomas Müller for their guidance
on microfluidic device design. The cuvette-filled icon in Fig. 3d is by Servier
[https://smart.servier.com/]. It is licensed under CC-BY 3.0 Unported [https://creativecommons.org/licenses/by/3.0/].
The authors would like to acknowledge Umeå Centre for Electron Microscopy (UCEM)
for technical assistance and access to electron microscopy. Support was provided
by SciLifeLab national Cryo-EM Unit at Umeå University.
article_number: '1933'
article_processing_charge: Yes
article_type: original
author:
- first_name: Jing
full_name: Hu, Jing
last_name: Hu
- first_name: Tom
full_name: Scheidt, Tom
last_name: Scheidt
- first_name: Dev
full_name: Thacker, Dev
last_name: Thacker
- first_name: Emil
full_name: Axell, Emil
last_name: Axell
- first_name: Elin
full_name: Stemme, Elin
last_name: Stemme
- first_name: Urszula
full_name: Łapińska, Urszula
last_name: Łapińska
- first_name: Stefan
full_name: Wennmalm, Stefan
last_name: Wennmalm
- first_name: Georg
full_name: Meisl, Georg
last_name: Meisl
- first_name: Samo
full_name: Curk, Samo
id: 031eff0d-d481-11ee-8508-cd12a7a86e5b
last_name: Curk
orcid: 0000-0001-6160-9766
- first_name: Maria
full_name: Andreasen, Maria
last_name: Andreasen
- first_name: Michele
full_name: Vendruscolo, Michele
last_name: Vendruscolo
- first_name: Paolo
full_name: Arosio, Paolo
last_name: Arosio
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Jeremy D.
full_name: Schmit, Jeremy D.
last_name: Schmit
- first_name: Tuomas P.J.
full_name: Knowles, Tuomas P.J.
last_name: Knowles
- first_name: Emma
full_name: Sparr, Emma
last_name: Sparr
- first_name: Sara
full_name: Linse, Sara
last_name: Linse
- first_name: Thomas C.T.
full_name: Michaels, Thomas C.T.
last_name: Michaels
- first_name: Alexander J.
full_name: Dear, Alexander J.
last_name: Dear
citation:
ama: Hu J, Scheidt T, Thacker D, et al. Structural defects in amyloid-β fibrils
drive secondary nucleation. Nature Communications. 2026;17. doi:10.1038/s41467-026-69377-1
apa: Hu, J., Scheidt, T., Thacker, D., Axell, E., Stemme, E., Łapińska, U., … Dear,
A. J. (2026). Structural defects in amyloid-β fibrils drive secondary nucleation.
Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-026-69377-1
chicago: Hu, Jing, Tom Scheidt, Dev Thacker, Emil Axell, Elin Stemme, Urszula Łapińska,
Stefan Wennmalm, et al. “Structural Defects in Amyloid-β Fibrils Drive Secondary
Nucleation.” Nature Communications. Springer Nature, 2026. https://doi.org/10.1038/s41467-026-69377-1.
ieee: J. Hu et al., “Structural defects in amyloid-β fibrils drive secondary
nucleation,” Nature Communications, vol. 17. Springer Nature, 2026.
ista: Hu J, Scheidt T, Thacker D, Axell E, Stemme E, Łapińska U, Wennmalm S, Meisl
G, Curk S, Andreasen M, Vendruscolo M, Arosio P, Šarić A, Schmit JD, Knowles TPJ,
Sparr E, Linse S, Michaels TCT, Dear AJ. 2026. Structural defects in amyloid-β
fibrils drive secondary nucleation. Nature Communications. 17, 1933.
mla: Hu, Jing, et al. “Structural Defects in Amyloid-β Fibrils Drive Secondary Nucleation.”
Nature Communications, vol. 17, 1933, Springer Nature, 2026, doi:10.1038/s41467-026-69377-1.
short: J. Hu, T. Scheidt, D. Thacker, E. Axell, E. Stemme, U. Łapińska, S. Wennmalm,
G. Meisl, S. Curk, M. Andreasen, M. Vendruscolo, P. Arosio, A. Šarić, J.D. Schmit,
T.P.J. Knowles, E. Sparr, S. Linse, T.C.T. Michaels, A.J. Dear, Nature Communications
17 (2026).
date_created: 2026-03-01T23:01:38Z
date_published: 2026-02-20T00:00:00Z
date_updated: 2026-03-02T09:36:48Z
day: '20'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1038/s41467-026-69377-1
ec_funded: 1
external_id:
pmid:
- '41708600'
file:
- access_level: open_access
checksum: fa2b55b3a0d8978de7d2d061c7ad8779
content_type: application/pdf
creator: dernst
date_created: 2026-03-02T09:34:18Z
date_updated: 2026-03-02T09:34:18Z
file_id: '21377'
file_name: 2026_NatureComm_Hu.pdf
file_size: 4821073
relation: main_file
success: 1
file_date_updated: 2026-03-02T09:34:18Z
has_accepted_license: '1'
intvolume: ' 17'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
call_identifier: H2020
grant_number: '802960'
name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Structural defects in amyloid-β fibrils drive secondary nucleation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '19846'
abstract:
- lang: eng
text: The Ca2+-release-activated Ca2+ (CRAC) channel Orai1 is activated by interaction
with the Ca2+ sensor Stromal Interaction Molecule 1 (STIM1). Owing to the lack
of structurally resolved Orai1/STIM1 complexes, the impact of their coupling on
individual Orai1 transmembrane domain (TM) movements is unclear. This study investigates
STIM1-independent and STIM1-dependent Orai1-TM dynamics using photocrosslinking
unnatural amino acids (UAAs) at each individual TM position. We primarily identify
CRAC-channel-like currents directly after UAA incorporation or additional UV-light
irradiation at TM3 sites that interface with non-pore-lining TMs. Using UAAs combined
with conventional site-directed mutagenesis and molecular dynamics simulations,
we discover that pore opening involves a widening of interfaces formed by TM3
with non-pore-lining TMs. Orai1 mutants with a UAA in TM3 exhibit weaker STIM1-induced
activation after UV exposure, possibly caused by a restricted widening of non-pore-lining
TM interfaces. We demonstrate that photocrosslinking UAAs are excellent tools
for improving our understanding of key determinants and ion channel dynamics modulating
pore opening.
acknowledgement: We thank S. Buchegger for excellent technical assistance. This research
was funded by the Austrian Science Fund (FWF) projects https://doi.org/10.55776/P32851,
https://doi.org/10.55776/P35900, and https://doi.org/10.55776/P36202 to I.D. and
https://doi.org/10.55776/PAT6871323 to A.T. N.M. is funded within the DOC program
of the OeAW (Austrian Academy of Science). For open access purposes, the author
has applied a CC BY public copyright license to any author-accepted manuscript version
arising from this submission.
article_number: '102623'
article_processing_charge: Yes
article_type: original
author:
- first_name: Hadil
full_name: Najjar, Hadil
last_name: Najjar
- first_name: Sarah
full_name: Weiß, Sarah
last_name: Weiß
- first_name: Ferdinand
full_name: Horvath, Ferdinand
id: b0dc7f61-21a3-11ef-a9b4-e6ab1aa6f21e
last_name: Horvath
- first_name: Valentina
full_name: Hopl, Valentina
last_name: Hopl
- first_name: Adéla
full_name: Tiffner, Adéla
last_name: Tiffner
- first_name: Lorenz
full_name: Höbarth, Lorenz
last_name: Höbarth
- first_name: Julia
full_name: Söllner, Julia
last_name: Söllner
- first_name: Maximilian
full_name: Fröhlich, Maximilian
last_name: Fröhlich
- first_name: Magdalena
full_name: Prantl, Magdalena
last_name: Prantl
- first_name: Nora
full_name: Müller, Nora
last_name: Müller
- first_name: Yuliia
full_name: Nazarenko, Yuliia
last_name: Nazarenko
- first_name: Selina
full_name: Harant, Selina
last_name: Harant
- first_name: Lukas
full_name: Weissenböck, Lukas
last_name: Weissenböck
- first_name: Herwig
full_name: Grabmayr, Herwig
last_name: Grabmayr
- first_name: Matthias
full_name: Sallinger, Matthias
last_name: Sallinger
- first_name: Lena
full_name: Maltan, Lena
last_name: Maltan
- first_name: Linda V.
full_name: Echefu, Linda V.
last_name: Echefu
- first_name: Tamara
full_name: Radiskovic, Tamara
last_name: Radiskovic
- first_name: Melanie
full_name: Leopold, Melanie
last_name: Leopold
- first_name: Sonja
full_name: Lindinger, Sonja
last_name: Lindinger
- first_name: Christina
full_name: Humer, Christina
last_name: Humer
- first_name: Carmen
full_name: Höglinger, Carmen
last_name: Höglinger
- first_name: Heinrich
full_name: Krobath, Heinrich
last_name: Krobath
- first_name: Thomas
full_name: Renger, Thomas
last_name: Renger
- first_name: Isabella
full_name: Derler, Isabella
last_name: Derler
citation:
ama: Najjar H, Weiß S, Horvath F, et al. STIM1-induced widening of non-pore-lining
TM interfaces is crucial for Orai1 pore opening. Cell Reports Physical Science.
2025;6(6). doi:10.1016/j.xcrp.2025.102623
apa: Najjar, H., Weiß, S., Horvath, F., Hopl, V., Tiffner, A., Höbarth, L., … Derler,
I. (2025). STIM1-induced widening of non-pore-lining TM interfaces is crucial
for Orai1 pore opening. Cell Reports Physical Science. Elsevier. https://doi.org/10.1016/j.xcrp.2025.102623
chicago: Najjar, Hadil, Sarah Weiß, Ferdinand Horvath, Valentina Hopl, Adéla Tiffner,
Lorenz Höbarth, Julia Söllner, et al. “STIM1-Induced Widening of Non-Pore-Lining
TM Interfaces Is Crucial for Orai1 Pore Opening.” Cell Reports Physical Science.
Elsevier, 2025. https://doi.org/10.1016/j.xcrp.2025.102623.
ieee: H. Najjar et al., “STIM1-induced widening of non-pore-lining TM interfaces
is crucial for Orai1 pore opening,” Cell Reports Physical Science, vol.
6, no. 6. Elsevier, 2025.
ista: Najjar H, Weiß S, Horvath F, Hopl V, Tiffner A, Höbarth L, Söllner J, Fröhlich
M, Prantl M, Müller N, Nazarenko Y, Harant S, Weissenböck L, Grabmayr H, Sallinger
M, Maltan L, Echefu LV, Radiskovic T, Leopold M, Lindinger S, Humer C, Höglinger
C, Krobath H, Renger T, Derler I. 2025. STIM1-induced widening of non-pore-lining
TM interfaces is crucial for Orai1 pore opening. Cell Reports Physical Science.
6(6), 102623.
mla: Najjar, Hadil, et al. “STIM1-Induced Widening of Non-Pore-Lining TM Interfaces
Is Crucial for Orai1 Pore Opening.” Cell Reports Physical Science, vol.
6, no. 6, 102623, Elsevier, 2025, doi:10.1016/j.xcrp.2025.102623.
short: H. Najjar, S. Weiß, F. Horvath, V. Hopl, A. Tiffner, L. Höbarth, J. Söllner,
M. Fröhlich, M. Prantl, N. Müller, Y. Nazarenko, S. Harant, L. Weissenböck, H.
Grabmayr, M. Sallinger, L. Maltan, L.V. Echefu, T. Radiskovic, M. Leopold, S.
Lindinger, C. Humer, C. Höglinger, H. Krobath, T. Renger, I. Derler, Cell Reports
Physical Science 6 (2025).
date_created: 2025-06-15T22:01:31Z
date_published: 2025-06-18T00:00:00Z
date_updated: 2025-09-30T12:53:15Z
day: '18'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1016/j.xcrp.2025.102623
external_id:
isi:
- '001516570500009'
file:
- access_level: open_access
checksum: 37ff7c396f966d0ec363e4691d63d402
content_type: application/pdf
creator: dernst
date_created: 2025-06-23T10:20:22Z
date_updated: 2025-06-23T10:20:22Z
file_id: '19868'
file_name: 2025_CellReportsPhysicalScience_Najjar.pdf
file_size: 9771117
relation: main_file
success: 1
file_date_updated: 2025-06-23T10:20:22Z
has_accepted_license: '1'
intvolume: ' 6'
isi: 1
issue: '6'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: Cell Reports Physical Science
publication_identifier:
eissn:
- 2666-3864
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: STIM1-induced widening of non-pore-lining TM interfaces is crucial for Orai1
pore opening
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 6
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
_id: '20318'
abstract:
- lang: eng
text: Lipid membranes and membrane deformations are a long-standing area of research
in soft matter and biophysics. Computer simulations have complemented analytical
and experimental approaches as one of the pillars in the field. However, setting
up and using membrane simulations can come with barriers due to the multidisciplinary
effort involved and the vast choice of existing simulations models. In this review,
we introduce the non-expert reader to coarse-grained membrane simulations at the
mesoscale. Firstly, we give a concise overview of the modelling approaches to
study fluid membranes, together with guidance to more specialized references.
Secondly, we provide a conceptual guide on how to develop mesoscale membrane simulations.
Lastly, we construct a hands-on tutorial on how to apply mesoscale membrane simulations,
by providing a pedagogical examination of membrane tether pulling, shape and mechanics
of membrane tubes, and membrane fluctuations with three different membrane models,
and discussing them in terms of their scope and how resource-intensive they are.
To ease the reader's venture into the field, we provide a repository with ready-to-run
tutorials.
acknowledgement: We thank Oded Farago, Angelo Cacciuto, Jeriann Beiter and Pietro
Sillano for helpful discussions and a critical reading of the manuscript. MMB and
AP acknowledge funding by the European Unions Horizon 2020 research and innovation
programme under Marie Skłodowska-Curie Grant Agreement No. 101034413. FF acknowledges
financial support by the NOMIS foundation. BM and AŠ acknowledge funding by ERC
Starting Grant “NEPA” 802960. MA and AŠ acknowledge funding by the Volkswagen Foundation
Grant Az 96727.
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Maitane
full_name: Muñoz Basagoiti, Maitane
id: 1a8a7950-82cd-11ed-bd4f-9624c913a607
last_name: Muñoz Basagoiti
orcid: 0000-0003-1483-1457
- first_name: Felix F
full_name: Frey, Felix F
id: a0270b37-8f1a-11ec-95c7-8e710c59a4f3
last_name: Frey
orcid: 0000-0001-8501-6017
- first_name: Billie
full_name: Meadowcroft, Billie
id: a4725fd6-932b-11ed-81e2-c098c7f37ae1
last_name: Meadowcroft
orcid: 0000-0003-3441-1337
- first_name: Miguel
full_name: Santana de Freitas Amaral, Miguel
id: 4f2d02dd-47a9-11ec-ad10-82820ed3f501
last_name: Santana de Freitas Amaral
- first_name: Adam
full_name: Prada, Adam
id: a43ed60a-dd22-11ed-9bf7-b34133792ea9
last_name: Prada
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
citation:
ama: 'Muñoz Basagoiti M, Frey FF, Meadowcroft B, Santana de Freitas Amaral M, Prada
A, Šarić A. A tutorial for mesoscale computer simulations of lipid membranes:
Tether pulling, tubulation and fluctuations. Soft Matter. 2025;21(40):7736-7756.
doi:10.1039/d5sm00148j'
apa: 'Muñoz Basagoiti, M., Frey, F. F., Meadowcroft, B., Santana de Freitas Amaral,
M., Prada, A., & Šarić, A. (2025). A tutorial for mesoscale computer simulations
of lipid membranes: Tether pulling, tubulation and fluctuations. Soft Matter.
Royal Society of Chemistry. https://doi.org/10.1039/d5sm00148j'
chicago: 'Muñoz Basagoiti, Maitane, Felix F Frey, Billie Meadowcroft, Miguel Santana
de Freitas Amaral, Adam Prada, and Anđela Šarić. “A Tutorial for Mesoscale Computer
Simulations of Lipid Membranes: Tether Pulling, Tubulation and Fluctuations.”
Soft Matter. Royal Society of Chemistry, 2025. https://doi.org/10.1039/d5sm00148j.'
ieee: 'M. Muñoz Basagoiti, F. F. Frey, B. Meadowcroft, M. Santana de Freitas Amaral,
A. Prada, and A. Šarić, “A tutorial for mesoscale computer simulations of lipid
membranes: Tether pulling, tubulation and fluctuations,” Soft Matter, vol.
21, no. 40. Royal Society of Chemistry, pp. 7736–7756, 2025.'
ista: 'Muñoz Basagoiti M, Frey FF, Meadowcroft B, Santana de Freitas Amaral M, Prada
A, Šarić A. 2025. A tutorial for mesoscale computer simulations of lipid membranes:
Tether pulling, tubulation and fluctuations. Soft Matter. 21(40), 7736–7756.'
mla: 'Muñoz Basagoiti, Maitane, et al. “A Tutorial for Mesoscale Computer Simulations
of Lipid Membranes: Tether Pulling, Tubulation and Fluctuations.” Soft Matter,
vol. 21, no. 40, Royal Society of Chemistry, 2025, pp. 7736–56, doi:10.1039/d5sm00148j.'
short: M. Muñoz Basagoiti, F.F. Frey, B. Meadowcroft, M. Santana de Freitas Amaral,
A. Prada, A. Šarić, Soft Matter 21 (2025) 7736–7756.
corr_author: '1'
date_created: 2025-09-10T05:34:36Z
date_published: 2025-07-28T00:00:00Z
date_updated: 2025-12-30T10:16:52Z
day: '28'
ddc:
- '540'
department:
- _id: AnSa
doi: 10.1039/d5sm00148j
ec_funded: 1
external_id:
arxiv:
- '2502.09798'
isi:
- '001562846800001'
file:
- access_level: open_access
checksum: 590bedad19b6f6d40a7ee036a056a6d9
content_type: application/pdf
creator: dernst
date_created: 2025-12-30T10:16:40Z
date_updated: 2025-12-30T10:16:40Z
file_id: '20912'
file_name: 2025_SoftMatter_MunozBasagoiti.pdf
file_size: 4841140
relation: main_file
success: 1
file_date_updated: 2025-12-30T10:16:40Z
has_accepted_license: '1'
intvolume: ' 21'
isi: 1
issue: '40'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '07'
oa: 1
oa_version: Published Version
page: 7736-7756
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
call_identifier: H2020
grant_number: '802960'
name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
- _id: 9B861AAC-BA93-11EA-9121-9846C619BF3A
name: NOMIS Fellowship Program
- _id: eba0f67c-77a9-11ec-83b8-cc8501b3e222
grant_number: '96752'
name: 'The evolution of trafficking: from archaea to eukaryotes'
publication: Soft Matter
publication_identifier:
eissn:
- 1744-6848
issn:
- 1744-683X
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'A tutorial for mesoscale computer simulations of lipid membranes: Tether pulling,
tubulation and fluctuations'
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 21
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20477'
abstract:
- lang: eng
text: An electric double-layer capacitor (EDLC) stores energy by modulating the
spatial distribution of ions in the electrolytic solution that it contains. We
determine the mean-field timescales for planar EDLC relaxation to equilibrium
after a potential difference is applied. We tackle first the fully symmetric case,
where positive and negative ionic species have the same valence and diffusivity,
and then the general, more complex, asymmetric case. Depending on the applied
voltage and salt concentration, different regimes appear, revealing a remarkably
rich phenomenology relevant for nanocapacitors.
acknowledgement: This work has received funding from the European Union’s Horizon
2020 and Horizon Europe research and innovation programs under the Marie Skłodowska-Curie
Grants No. 674979-NANOTRANS (I. P., P. B. W., B. R., E. T.), No. 101034413 (I. P.),
and No. 101119598-FLUXIONIC (M. D., B. R., E. T.), as well as from the European
Research Council under Grant No. 863473 (B. R.). B. R. acknowledges financial support
from the French Agence Nationale de la Recherche (ANR) under Grant No. ANR-21-CE29-0021-02
(DIADEM). I. P. thanks Anđela Šarić for further support at ISTA.
article_number: '148002'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Ivan
full_name: Palaia, Ivan
id: 9c805cd2-4b75-11ec-a374-db6dd0ed57fa
last_name: Palaia
orcid: ' 0000-0002-8843-9485 '
- first_name: Adelchi J.
full_name: Asta, Adelchi J.
last_name: Asta
- first_name: Megh
full_name: Dutta, Megh
last_name: Dutta
- first_name: Patrick B.
full_name: Warren, Patrick B.
last_name: Warren
- first_name: Benjamin
full_name: Rotenberg, Benjamin
last_name: Rotenberg
- first_name: Emmanuel
full_name: Trizac, Emmanuel
last_name: Trizac
citation:
ama: Palaia I, Asta AJ, Dutta M, Warren PB, Rotenberg B, Trizac E. Charging dynamics
of electric double-layer nanocapacitors in mean field. Physical Review Letters.
2025;135(14). doi:10.1103/72b9-c8cq
apa: Palaia, I., Asta, A. J., Dutta, M., Warren, P. B., Rotenberg, B., & Trizac,
E. (2025). Charging dynamics of electric double-layer nanocapacitors in mean field.
Physical Review Letters. American Physical Society. https://doi.org/10.1103/72b9-c8cq
chicago: Palaia, Ivan, Adelchi J. Asta, Megh Dutta, Patrick B. Warren, Benjamin
Rotenberg, and Emmanuel Trizac. “Charging Dynamics of Electric Double-Layer Nanocapacitors
in Mean Field.” Physical Review Letters. American Physical Society, 2025.
https://doi.org/10.1103/72b9-c8cq.
ieee: I. Palaia, A. J. Asta, M. Dutta, P. B. Warren, B. Rotenberg, and E. Trizac,
“Charging dynamics of electric double-layer nanocapacitors in mean field,” Physical
Review Letters, vol. 135, no. 14. American Physical Society, 2025.
ista: Palaia I, Asta AJ, Dutta M, Warren PB, Rotenberg B, Trizac E. 2025. Charging
dynamics of electric double-layer nanocapacitors in mean field. Physical Review
Letters. 135(14), 148002.
mla: Palaia, Ivan, et al. “Charging Dynamics of Electric Double-Layer Nanocapacitors
in Mean Field.” Physical Review Letters, vol. 135, no. 14, 148002, American
Physical Society, 2025, doi:10.1103/72b9-c8cq.
short: I. Palaia, A.J. Asta, M. Dutta, P.B. Warren, B. Rotenberg, E. Trizac, Physical
Review Letters 135 (2025).
corr_author: '1'
date_created: 2025-10-16T13:09:30Z
date_published: 2025-09-29T00:00:00Z
date_updated: 2025-12-01T15:02:16Z
day: '29'
ddc:
- '530'
department:
- _id: AnSa
doi: 10.1103/72b9-c8cq
ec_funded: 1
external_id:
arxiv:
- '2301.00610'
isi:
- '001587121300010'
file:
- access_level: open_access
checksum: e29809fea48b18217d1779980f7117c4
content_type: application/pdf
creator: dernst
date_created: 2025-10-23T11:57:20Z
date_updated: 2025-10-23T11:57:20Z
file_id: '20526'
file_name: 2025_PhysReviewLetters_Palaia.pdf
file_size: 480414
relation: main_file
success: 1
file_date_updated: 2025-10-23T11:57:20Z
has_accepted_license: '1'
intvolume: ' 135'
isi: 1
issue: '14'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: Physical Review Letters
publication_identifier:
eissn:
- 1079-7114
issn:
- 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Charging dynamics of electric double-layer nanocapacitors in mean field
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 135
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20483'
abstract:
- lang: eng
text: A parallel plate capacitor containing an electrolytic solution is the simplest
model of a supercapacitor or electric double-layer capacitor. Using both analytical
and numerical techniques, we solve the Poisson-Nernst-Planck equations for such
a system, describing the mean-field charging dynamics of the capacitor, when a
constant potential difference is abruptly applied to its plates. Working at constant
total number of ions, we focus on the physical processes involved in the relaxation
and, whenever possible, give its functional shape and exact time constants. We
first review and study the case of a symmetric binary electrolyte, where we assume
the two ionic species to have the same charges and diffusivities. We then relax
these assumptions and present results for a generic strong (i.e fully dissociated)
binary electrolyte. At low electrolyte concentration, the relaxation is simple
to understand, as the dynamics of positive and negative ions appear decoupled.
At higher electrolyte concentration, we distinguish several regimes. In the linear
regime (low voltages), relaxation is multiexponential, it starts by the buildup
of the equilibrium charge profile and continues with neutral mass diffusion, and
the relevant timescales feature both the average and the Nernst-Hartley diffusion
coefficients. In the purely nonlinear regime (intermediate voltages), the initial
relaxation is slowed down exponentially due to increased capacitance, while bulk
effects become more and more evident. In the fully nonlinear regime (high voltages),
the dynamics of charge and mass are completely entangled and, asymptotically,
the relaxation is linear in time. We finally discuss nonideal behavior in real
capacitors and provide conditions for which mean-field is expected to hold.
acknowledgement: This work has received funding from the European Union's Horizon
2020 and Horizon Europe research and innovation programs under the Marie Skłodowska-Curie
Grants No. 674979-NANOTRANS (I.P., P.B.W., B.R., and E.T.), No. 101034413 (I.P.),
and No. 101119598-FLUXIONIC (M.D., B.R., and E.T.), as well as from the European
Research Council under Grant No. 863473 (B.R.). B.R. acknowledges financial support
from the French Agence Nationale de la Recherche (ANR) under Grant No. ANR-21-CE29-0021-02
(DIADEM). I.P. thanks Anđela Šarić for further support at ISTA.
article_number: '035417'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Ivan
full_name: Palaia, Ivan
id: 9c805cd2-4b75-11ec-a374-db6dd0ed57fa
last_name: Palaia
orcid: ' 0000-0002-8843-9485 '
- first_name: Adelchi J.
full_name: Asta, Adelchi J.
last_name: Asta
- first_name: Megh
full_name: Dutta, Megh
last_name: Dutta
- first_name: Patrick B.
full_name: Warren, Patrick B.
last_name: Warren
- first_name: Benjamin
full_name: Rotenberg, Benjamin
last_name: Rotenberg
- first_name: Emmanuel
full_name: Trizac, Emmanuel
last_name: Trizac
citation:
ama: 'Palaia I, Asta AJ, Dutta M, Warren PB, Rotenberg B, Trizac E. Poisson-Nernst-Planck
charging dynamics of an electric double-layer capacitor: Symmetric and asymmetric
binary electrolytes. Physical Review E. 2025;112(3). doi:10.1103/p4dg-snqf'
apa: 'Palaia, I., Asta, A. J., Dutta, M., Warren, P. B., Rotenberg, B., & Trizac,
E. (2025). Poisson-Nernst-Planck charging dynamics of an electric double-layer
capacitor: Symmetric and asymmetric binary electrolytes. Physical Review E.
American Physical Society. https://doi.org/10.1103/p4dg-snqf'
chicago: 'Palaia, Ivan, Adelchi J. Asta, Megh Dutta, Patrick B. Warren, Benjamin
Rotenberg, and Emmanuel Trizac. “Poisson-Nernst-Planck Charging Dynamics of an
Electric Double-Layer Capacitor: Symmetric and Asymmetric Binary Electrolytes.”
Physical Review E. American Physical Society, 2025. https://doi.org/10.1103/p4dg-snqf.'
ieee: 'I. Palaia, A. J. Asta, M. Dutta, P. B. Warren, B. Rotenberg, and E. Trizac,
“Poisson-Nernst-Planck charging dynamics of an electric double-layer capacitor:
Symmetric and asymmetric binary electrolytes,” Physical Review E, vol.
112, no. 3. American Physical Society, 2025.'
ista: 'Palaia I, Asta AJ, Dutta M, Warren PB, Rotenberg B, Trizac E. 2025. Poisson-Nernst-Planck
charging dynamics of an electric double-layer capacitor: Symmetric and asymmetric
binary electrolytes. Physical Review E. 112(3), 035417.'
mla: 'Palaia, Ivan, et al. “Poisson-Nernst-Planck Charging Dynamics of an Electric
Double-Layer Capacitor: Symmetric and Asymmetric Binary Electrolytes.” Physical
Review E, vol. 112, no. 3, 035417, American Physical Society, 2025, doi:10.1103/p4dg-snqf.'
short: I. Palaia, A.J. Asta, M. Dutta, P.B. Warren, B. Rotenberg, E. Trizac, Physical
Review E 112 (2025).
corr_author: '1'
date_created: 2025-10-16T13:15:16Z
date_published: 2025-09-29T00:00:00Z
date_updated: 2025-12-01T13:06:51Z
day: '29'
ddc:
- '530'
department:
- _id: AnSa
doi: 10.1103/p4dg-snqf
ec_funded: 1
external_id:
arxiv:
- '2303.07859'
isi:
- '001586173200001'
file:
- access_level: open_access
checksum: 658a9b1ce6b2edcf138b54c55a566f0e
content_type: application/pdf
creator: dernst
date_created: 2025-10-23T09:15:56Z
date_updated: 2025-10-23T09:15:56Z
file_id: '20521'
file_name: 2025_PhysReviewE_Palaia.pdf
file_size: 1211712
relation: main_file
success: 1
file_date_updated: 2025-10-23T09:15:56Z
has_accepted_license: '1'
intvolume: ' 112'
isi: 1
issue: '3'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: Physical Review E
publication_identifier:
eissn:
- 2470-0053
issn:
- 2470-0045
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Poisson-Nernst-Planck charging dynamics of an electric double-layer capacitor:
Symmetric and asymmetric binary electrolytes'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 112
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '18820'
abstract:
- lang: eng
text: 'Feature selection is essential in the analysis of molecular systems and many
other fields, but several uncertainties remain: What is the optimal number of
features for a simplified, interpretable model that retains essential information?
How should features with different units be aligned, and how should their relative
importance be weighted? Here, we introduce the Differentiable Information Imbalance
(DII), an automated method to rank information content between sets of features.
Using distances in a ground truth feature space, DII identifies a low-dimensional
subset of features that best preserves these relationships. Each feature is scaled
by a weight, which is optimized by minimizing the DII through gradient descent.
This allows simultaneously performing unit alignment and relative importance scaling,
while preserving interpretability. DII can also produce sparse solutions and determine
the optimal size of the reduced feature space. We demonstrate the usefulness of
this approach on two benchmark molecular problems: (1) identifying collective
variables that describe conformations of a biomolecule, and (2) selecting features
for training a machine-learning force field. These results show the potential
of DII in addressing feature selection challenges and optimizing dimensionality
in various applications. The method is available in the Python library DADApy.'
acknowledgement: The authors thank Dr. Matteo Carli for providing the CLN025 replica
exchange MD trajectory and Matteo Allione for the fruitful discussions connected
with the idea of the linear scaling estimator. This work was partially funded by
NextGenerationEU through the Italian National Centre for HPC, Big Data, and Quantum
Computing (Grant No. CN00000013 received by A.L.). A.L. also acknowledges financial
support by the region Friuli Venezia Giulia (project F53C22001770002 received by
A.L.).
article_number: '270'
article_processing_charge: Yes
article_type: original
author:
- first_name: Romina
full_name: Wild, Romina
last_name: Wild
- first_name: Felix
full_name: Wodaczek, Felix
id: 8b4b6a9f-32b0-11ee-9fa8-bbe85e26258e
last_name: Wodaczek
orcid: 0009-0000-1457-795X
- first_name: Vittorio
full_name: Del Tatto, Vittorio
last_name: Del Tatto
- first_name: Bingqing
full_name: Cheng, Bingqing
id: cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9
last_name: Cheng
orcid: 0000-0002-3584-9632
- first_name: Alessandro
full_name: Laio, Alessandro
last_name: Laio
citation:
ama: Wild R, Wodaczek F, Del Tatto V, Cheng B, Laio A. Automatic feature selection
and weighting in molecular systems using Differentiable Information Imbalance.
Nature Communications. 2025;16. doi:10.1038/s41467-024-55449-7
apa: Wild, R., Wodaczek, F., Del Tatto, V., Cheng, B., & Laio, A. (2025). Automatic
feature selection and weighting in molecular systems using Differentiable Information
Imbalance. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-024-55449-7
chicago: Wild, Romina, Felix Wodaczek, Vittorio Del Tatto, Bingqing Cheng, and Alessandro
Laio. “Automatic Feature Selection and Weighting in Molecular Systems Using Differentiable
Information Imbalance.” Nature Communications. Springer Nature, 2025. https://doi.org/10.1038/s41467-024-55449-7.
ieee: R. Wild, F. Wodaczek, V. Del Tatto, B. Cheng, and A. Laio, “Automatic feature
selection and weighting in molecular systems using Differentiable Information
Imbalance,” Nature Communications, vol. 16. Springer Nature, 2025.
ista: Wild R, Wodaczek F, Del Tatto V, Cheng B, Laio A. 2025. Automatic feature
selection and weighting in molecular systems using Differentiable Information
Imbalance. Nature Communications. 16, 270.
mla: Wild, Romina, et al. “Automatic Feature Selection and Weighting in Molecular
Systems Using Differentiable Information Imbalance.” Nature Communications,
vol. 16, 270, Springer Nature, 2025, doi:10.1038/s41467-024-55449-7.
short: R. Wild, F. Wodaczek, V. Del Tatto, B. Cheng, A. Laio, Nature Communications
16 (2025).
date_created: 2025-01-12T23:04:00Z
date_published: 2025-01-02T00:00:00Z
date_updated: 2025-02-27T12:41:25Z
day: '02'
ddc:
- '570'
department:
- _id: AnSa
- _id: BiCh
doi: 10.1038/s41467-024-55449-7
external_id:
isi:
- '001389959100009'
pmid:
- '39747013'
file:
- access_level: open_access
checksum: b3d0f3568d9a87c494cf231a5324029a
content_type: application/pdf
creator: dernst
date_created: 2025-01-14T06:59:25Z
date_updated: 2025-01-14T06:59:25Z
file_id: '18846'
file_name: 2025_NatureComm_Wild.pdf
file_size: 1216738
relation: main_file
success: 1
file_date_updated: 2025-01-14T06:59:25Z
has_accepted_license: '1'
intvolume: ' 16'
isi: 1
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Automatic feature selection and weighting in molecular systems using Differentiable
Information Imbalance
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20530'
abstract:
- lang: eng
text: Cells must coordinate DNA segregation with cytokinesis to ensure that each
daughter cell inherits a complete genome. Here, we explore how DNA segregation
and division are mechanistically coupled in archaeal relatives of eukaryotes,
which lack Cyclin-dependent kinase (CDK)/Cyclins. Using live cell imaging, we
first describe the series of sequential changes in DNA organization that accompany
cell division in Sulfolobus, which computational modeling shows likely aid genome
segregation. Through a perturbation analysis we identify a regulatory checkpoint
which ensures that the compaction of the genome into two spatially segregated
nucleoids only occurs once cells have assembled a division ring—which also defines
the axis of DNA segregation. Finally, we show that DNA compaction and segregation
depend, in part, on a ParA homologue, SegA, and its partner SegB, whose absence
leads to bridging DNA. Taken together, these data show how regulatory checkpoints
like those operating in eukaryotes aid high-fidelity division in an archaeon.
acknowledgement: We thank Matthew Kenneth for his assistance with live cell imaging.
We thank Arthur Charles-Orszag and Dyche Mullins for generously gifting the SegA
and SegB antibodies, and Sonja-Verena Albers for gifting the CdvA-HA overexpression
plasmid. We thank the Light Microscopy and Flow Cytometry facilities at the MRC-LMB,
and all the core staff at the MRC-LMB for their support. We thank all members of
the Baum lab for helpful discussions. We would like to thank Magdalena Lechowska,
Gautam Dey, Laura Downie, and Iva Tolic for critical reading of the manuscript.
J.P. was supported by the Medical Research Council—Laboratory of Molecular Biology
(MC_UP_1201/27). A.C. was funded by an EMBO Postdoctoral fellowship (ALTF_1041-2021),
a Marie Sklodowska-Curie Individual Fellowship (101068523) provided by UKRI and
by the Wellcome Trust (222460/Z/21/Z). B.H. was supported by Wellcome Trust (203276/A/16/Z).
Y.-W.K. was supported by an EMBO postdoctoral fellowship (ALTF 903-2021) and by
the Medical Research Council—Laboratory of Molecular Biology (MC_UP_1201/27); S.F.
was supported by the Wellcome Trust (222460/Z/21/Z); B.B. received support from
the MRC LMB, the Wellcome Trust (203276/Z/16/Z) and (222460/Z/21/Z), the VW Foundation
(94933), and from the Gordon and Betty Moore Foundation’s Symbiosis in Aquatic Systems
Initiative (9346). V.S. and A.Š. acknowledge funding from the European Research
Council under the European Union’s Horizon 2020 research and innovation programme
(grant no.802960 to A.Š.), the Vallee Scholarship, and the EMBO Young Investigator
Programme (A.Š.). The collaborative work of A.Š.’s and B.B. teams was also supported
by a Moore–Simons Project on the Origin of the Eukaryotic Cell, Simons Foundation
735929LPI.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Joe
full_name: Parham, Joe
last_name: Parham
- first_name: Valerio
full_name: Sorichetti, Valerio
id: ef8a92cb-c7b6-11ec-8bea-e1fd5847bc5b
last_name: Sorichetti
orcid: 0000-0002-9645-6576
- first_name: Alice
full_name: Cezanne, Alice
last_name: Cezanne
- first_name: Sherman
full_name: Foo, Sherman
last_name: Foo
- first_name: Yin Wei
full_name: Kuo, Yin Wei
last_name: Kuo
- first_name: Baukje
full_name: Hoogenberg, Baukje
last_name: Hoogenberg
- first_name: Arthur
full_name: Radoux-Mergault, Arthur
last_name: Radoux-Mergault
- first_name: Eloise
full_name: Mawdesley, Eloise
last_name: Mawdesley
- first_name: Lydia Daniels
full_name: Gatward, Lydia Daniels
last_name: Gatward
- first_name: Jerome
full_name: Boulanger, Jerome
last_name: Boulanger
- first_name: Ulrike
full_name: Schulze, Ulrike
last_name: Schulze
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Buzz
full_name: Baum, Buzz
last_name: Baum
citation:
ama: Parham J, Sorichetti V, Cezanne A, et al. Temporal and spatial coordination
of DNA segregation and cell division in an archaeon. Proceedings of the National
Academy of Sciences. 2025;122(42):e2513939122. doi:10.1073/pnas.2513939122
apa: Parham, J., Sorichetti, V., Cezanne, A., Foo, S., Kuo, Y. W., Hoogenberg, B.,
… Baum, B. (2025). Temporal and spatial coordination of DNA segregation and cell
division in an archaeon. Proceedings of the National Academy of Sciences.
National Academy of Sciences. https://doi.org/10.1073/pnas.2513939122
chicago: Parham, Joe, Valerio Sorichetti, Alice Cezanne, Sherman Foo, Yin Wei Kuo,
Baukje Hoogenberg, Arthur Radoux-Mergault, et al. “Temporal and Spatial Coordination
of DNA Segregation and Cell Division in an Archaeon.” Proceedings of the National
Academy of Sciences. National Academy of Sciences, 2025. https://doi.org/10.1073/pnas.2513939122.
ieee: J. Parham et al., “Temporal and spatial coordination of DNA segregation
and cell division in an archaeon,” Proceedings of the National Academy of Sciences,
vol. 122, no. 42. National Academy of Sciences, p. e2513939122, 2025.
ista: Parham J, Sorichetti V, Cezanne A, Foo S, Kuo YW, Hoogenberg B, Radoux-Mergault
A, Mawdesley E, Gatward LD, Boulanger J, Schulze U, Šarić A, Baum B. 2025. Temporal
and spatial coordination of DNA segregation and cell division in an archaeon.
Proceedings of the National Academy of Sciences. 122(42), e2513939122.
mla: Parham, Joe, et al. “Temporal and Spatial Coordination of DNA Segregation and
Cell Division in an Archaeon.” Proceedings of the National Academy of Sciences,
vol. 122, no. 42, National Academy of Sciences, 2025, p. e2513939122, doi:10.1073/pnas.2513939122.
short: J. Parham, V. Sorichetti, A. Cezanne, S. Foo, Y.W. Kuo, B. Hoogenberg, A.
Radoux-Mergault, E. Mawdesley, L.D. Gatward, J. Boulanger, U. Schulze, A. Šarić,
B. Baum, Proceedings of the National Academy of Sciences 122 (2025) e2513939122.
date_created: 2025-10-26T23:01:33Z
date_published: 2025-10-21T00:00:00Z
date_updated: 2026-02-16T12:32:31Z
day: '21'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1073/pnas.2513939122
ec_funded: 1
external_id:
isi:
- '001620648600001'
pmid:
- '41091768'
file:
- access_level: open_access
checksum: 3555d51f438d2e356039a9b697eac3ee
content_type: application/pdf
creator: dernst
date_created: 2025-10-27T08:12:59Z
date_updated: 2025-10-27T08:12:59Z
file_id: '20543'
file_name: 2025_PNAS_Parham.pdf
file_size: 2649194
relation: main_file
success: 1
file_date_updated: 2025-10-27T08:12:59Z
has_accepted_license: '1'
intvolume: ' 122'
isi: 1
issue: '42'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: e2513939122
pmid: 1
project:
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
call_identifier: H2020
grant_number: '802960'
name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
- _id: 349b6ff1-11ca-11ed-8bc3-f006047c2eeb
name: EMBO Young Investigator Program - Andela Saric
publication: Proceedings of the National Academy of Sciences
publication_identifier:
eissn:
- 1091-6490
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Temporal and spatial coordination of DNA segregation and cell division in an
archaeon
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 122
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21235'
abstract:
- lang: eng
text: The condensation of charged polymers is an important driver for the formation
of biomolecular condensates. Recent experiments suggest that this mechanism also
controls the clustering of eukaryotic chromosomes during the late stages of cell
division. In this process, interchromosome attraction is driven by the condensation
of cytoplasmic RNA and Ki-67, a charged intrinsically disordered protein that
coats the chromosomes as a brush. Attraction between chromosomes has been shown
to be specifically promoted by a localized charged patch on Ki-67, although the
physical mechanism remains unclear. To elucidate this process, we combine coarse-grained
simulations and analytical theory to study the RNA-mediated interaction between
charged polymer brushes on the chromosome surfaces. We show that the charged patch
on Ki-67 leads to interchromosome attraction via RNA bridging between the two
brushes, whereby the RNA preferentially interacts with the charged patches, leading
to stable, long-range forces. By contrast, if the brush is uniformly charged,
bridging is basically absent due to complete adsorption of RNA onto the brush.
Moreover, the RNA dynamics becomes caged in presence of the charged patch while
remaining diffusive with uniform charge. Our work sheds light on the physical
origin of chromosome clustering, while also suggesting a general mechanism for
cells to tune work production by biomolecular condensates via different charge
distributions.
acknowledgement: "This work was supported by the European Union’s Horizon 2020 research
and innovation programme (A.Š. and V.S., ERC grant Agreement No. 802960 to A.Š.,
I.P. and P.R.,\r\nMarie Skłodowska-Curie Grant Agreement No. 101034413), the German
Research Foundation (S.C-H. and A.H.-A., DFG Project No. 402723784 to S.C-H.), the
Vallee Scholarship\r\n(A.Š. and V.S.), the EMBO Young Investigator Programme (A.Š.),
and a Ph.D. fellowship from the Boehringer Ingelheim Fonds (A.H.-A.)."
article_number: '033010'
article_processing_charge: Yes
article_type: original
author:
- first_name: Valerio
full_name: Sorichetti, Valerio
id: ef8a92cb-c7b6-11ec-8bea-e1fd5847bc5b
last_name: Sorichetti
orcid: 0000-0002-9645-6576
- first_name: Paul
full_name: Robin, Paul
id: 48c58128-57b0-11ee-9095-dc28fd97fc1d
last_name: Robin
orcid: 0000-0002-5728-9189
- first_name: Ivan
full_name: Palaia, Ivan
id: 9c805cd2-4b75-11ec-a374-db6dd0ed57fa
last_name: Palaia
orcid: ' 0000-0002-8843-9485 '
- first_name: Alberto
full_name: Hernandez-Armendariz, Alberto
last_name: Hernandez-Armendariz
- first_name: Sara
full_name: Cuylen-Haering, Sara
last_name: Cuylen-Haering
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
citation:
ama: Sorichetti V, Robin P, Palaia I, Hernandez-Armendariz A, Cuylen-Haering S,
Šarić A. Charge distribution of the coating brush drives interchromosome attraction.
PRX Life. 2025;3(3). doi:10.1103/41fd-r847
apa: Sorichetti, V., Robin, P., Palaia, I., Hernandez-Armendariz, A., Cuylen-Haering,
S., & Šarić, A. (2025). Charge distribution of the coating brush drives interchromosome
attraction. PRX Life. American Physical Society. https://doi.org/10.1103/41fd-r847
chicago: Sorichetti, Valerio, Paul Robin, Ivan Palaia, Alberto Hernandez-Armendariz,
Sara Cuylen-Haering, and Anđela Šarić. “Charge Distribution of the Coating Brush
Drives Interchromosome Attraction.” PRX Life. American Physical Society,
2025. https://doi.org/10.1103/41fd-r847.
ieee: V. Sorichetti, P. Robin, I. Palaia, A. Hernandez-Armendariz, S. Cuylen-Haering,
and A. Šarić, “Charge distribution of the coating brush drives interchromosome
attraction,” PRX Life, vol. 3, no. 3. American Physical Society, 2025.
ista: Sorichetti V, Robin P, Palaia I, Hernandez-Armendariz A, Cuylen-Haering S,
Šarić A. 2025. Charge distribution of the coating brush drives interchromosome
attraction. PRX Life. 3(3), 033010.
mla: Sorichetti, Valerio, et al. “Charge Distribution of the Coating Brush Drives
Interchromosome Attraction.” PRX Life, vol. 3, no. 3, 033010, American
Physical Society, 2025, doi:10.1103/41fd-r847.
short: V. Sorichetti, P. Robin, I. Palaia, A. Hernandez-Armendariz, S. Cuylen-Haering,
A. Šarić, PRX Life 3 (2025).
corr_author: '1'
date_created: 2026-02-16T14:50:32Z
date_published: 2025-08-11T00:00:00Z
date_updated: 2026-02-17T11:16:26Z
day: '11'
ddc:
- '570'
department:
- _id: AnSa
- _id: EdHa
doi: 10.1103/41fd-r847
ec_funded: 1
file:
- access_level: open_access
checksum: 1702b9bdbfd902a7c08aa4f1479b390d
content_type: application/pdf
creator: dernst
date_created: 2026-02-17T11:12:30Z
date_updated: 2026-02-17T11:12:30Z
file_id: '21287'
file_name: 2025_PRXLife_Sorichetti.pdf
file_size: 3732843
relation: main_file
success: 1
file_date_updated: 2026-02-17T11:12:30Z
has_accepted_license: '1'
intvolume: ' 3'
issue: '3'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
call_identifier: H2020
grant_number: '802960'
name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
- _id: 349b6ff1-11ca-11ed-8bc3-f006047c2eeb
name: EMBO Young Investigator Program - Andela Saric
publication: PRX Life
publication_identifier:
eissn:
- 2835-8279
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Charge distribution of the coating brush drives interchromosome attraction
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21251'
abstract:
- lang: eng
text: Cellular membranes differ across the tree of life. In most bacteria and eukaryotes,
single-headed lipids self-assemble into flexible bilayer membranes. By contrast,
thermophilic archaea tend to possess bilayer lipids together with double-headed,
monolayer spanning bolalipids, which are thought to enable cells to survive in
harsh environments. Here, using a minimal computational model for bolalipid membranes,
we explore the trade-offs at play when forming membranes. We find that flexible
bolalipids form membranes that resemble bilayer membranes because they are able
to assume a U-shaped conformation. Conversely, rigid bolalipids, which resemble
the bolalipids with cyclic groups found in thermophilic archaea, take on a straight
conformation and form membranes that are stiff and prone to pore formation when
they undergo changes in shape. Strikingly, however, the inclusion of small amounts
of bilayer lipids in a bolalipid membrane is enough to achieve fluid bolalipid
membranes that are both stable and flexible, resolving this trade-off. Our study
suggests a mechanism by which archaea can tune the material properties of their
membranes as and when required to enable them to survive in harsh environments
and to undergo essential membrane remodelling events like cell division.
acknowledgement: MA, BB, and AŠ acknowledge funding by the Volkswagen Foundation Grant
Az 96727. FF acknowledges financial support by the NOMIS foundation. AŠ acknowledges
funding by ERC Starting Grant 'NEPA' 802960. We thank Claudia Flandoli for her help
with illustrations.
article_number: '105432'
article_processing_charge: Yes
article_type: original
author:
- first_name: Miguel
full_name: Santana de Freitas Amaral, Miguel
id: 4f2d02dd-47a9-11ec-ad10-82820ed3f501
last_name: Santana de Freitas Amaral
- first_name: Felix F
full_name: Frey, Felix F
id: a0270b37-8f1a-11ec-95c7-8e710c59a4f3
last_name: Frey
orcid: 0000-0001-8501-6017
- first_name: Xiuyun
full_name: Jiang, Xiuyun
last_name: Jiang
- first_name: Buzz
full_name: Baum, Buzz
last_name: Baum
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
citation:
ama: Santana de Freitas Amaral M, Frey FF, Jiang X, Baum B, Šarić A. Balancing stability
and flexibility when reshaping archaeal membranes. eLife. 2025;14. doi:10.7554/elife.105432
apa: Santana de Freitas Amaral, M., Frey, F. F., Jiang, X., Baum, B., & Šarić,
A. (2025). Balancing stability and flexibility when reshaping archaeal membranes.
ELife. eLife Sciences Publications. https://doi.org/10.7554/elife.105432
chicago: Santana de Freitas Amaral, Miguel, Felix F Frey, Xiuyun Jiang, Buzz Baum,
and Anđela Šarić. “Balancing Stability and Flexibility When Reshaping Archaeal
Membranes.” ELife. eLife Sciences Publications, 2025. https://doi.org/10.7554/elife.105432.
ieee: M. Santana de Freitas Amaral, F. F. Frey, X. Jiang, B. Baum, and A. Šarić,
“Balancing stability and flexibility when reshaping archaeal membranes,” eLife,
vol. 14. eLife Sciences Publications, 2025.
ista: Santana de Freitas Amaral M, Frey FF, Jiang X, Baum B, Šarić A. 2025. Balancing
stability and flexibility when reshaping archaeal membranes. eLife. 14, 105432.
mla: Santana de Freitas Amaral, Miguel, et al. “Balancing Stability and Flexibility
When Reshaping Archaeal Membranes.” ELife, vol. 14, 105432, eLife Sciences
Publications, 2025, doi:10.7554/elife.105432.
short: M. Santana de Freitas Amaral, F.F. Frey, X. Jiang, B. Baum, A. Šarić, ELife
14 (2025).
corr_author: '1'
date_created: 2026-02-16T15:43:57Z
date_published: 2025-10-07T00:00:00Z
date_updated: 2026-02-23T11:49:05Z
day: '07'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.7554/elife.105432
ec_funded: 1
external_id:
pmid:
- '41056191 '
file:
- access_level: open_access
checksum: 4116cd5143558ded995fb9ff5fcbc7e0
content_type: application/pdf
creator: dernst
date_created: 2026-02-17T13:02:02Z
date_updated: 2026-02-17T13:02:02Z
file_id: '21305'
file_name: 2025_elife_Amaral.pdf
file_size: 10668225
relation: main_file
success: 1
file_date_updated: 2026-02-17T13:02:02Z
has_accepted_license: '1'
intvolume: ' 14'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
call_identifier: H2020
grant_number: '802960'
name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
publication: eLife
publication_identifier:
eissn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
related_material:
record:
- id: '21304'
relation: software
status: public
status: public
title: Balancing stability and flexibility when reshaping archaeal membranes
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21256'
abstract:
- lang: eng
text: Collagen IV is one of the main components of the basement membrane, a layer
of material that lines the majority of tissues in multicellular organisms. Collagen
IV molecules assemble into networks, providing stiffness and elasticity to tissues
and informing cell and organ shape, especially during development. In this work,
we develop two coarse-grained models for collagen IV molecules that retain biochemical
bond specificity and coarse grain at different length scales. Through molecular-dynamics
simulations, we test the assembly and mechanics of the resulting networks and
measure their response to strain in terms of stress, microscopic alignment, and
bond dynamics. Within the basement membrane, collagen IV networks rearrange by
molecule turnover, which affects tissue organization and can be linked with enzyme
activity. Here we explore network rearrangements via bond remodeling, the process
of breaking and remaking of bonds between network molecules. We then investigate
the effects of active (enzymatic) bond remodeling. We find that this nonequilibrium
remodeling allows a network to keep its integrity under strain, while relaxing
fully over a variety of timescales, a dynamic response that is unavailable to
networks undergoing equilibrium remodeling.
acknowledgement: This work received funding from the European Research Council under
the European Union's Horizon 2020 research and innovation program through Grant
Agreement No. 802960 (B.M., V.S., I.P., and A.Š.), the European Union's Horizon
2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement
No. 101034413 (I.P.), the NOMIS Foundation (F.P.-V.), the National Centre for the
Replacement, Refinement and Reduction of Animals in Research Grant No. NC/T002425/1
(N.K.), Leverhulme Trust project Grant No. RPG-2020-068 (N.K.), MRC Fellowship No.
MR/W027437/1 (Y.M.), a Lister Institute Research Prize (Y.M.) and EMBO Young Investigator
Programme (Y.M. and A.Š.).
article_number: '033019'
article_processing_charge: Yes
article_type: original
author:
- first_name: Billie
full_name: Meadowcroft, Billie
id: a4725fd6-932b-11ed-81e2-c098c7f37ae1
last_name: Meadowcroft
orcid: 0000-0003-3441-1337
- first_name: Valerio
full_name: Sorichetti, Valerio
id: ef8a92cb-c7b6-11ec-8bea-e1fd5847bc5b
last_name: Sorichetti
orcid: 0000-0002-9645-6576
- first_name: Eryk
full_name: Ratajczyk, Eryk
last_name: Ratajczyk
- first_name: Fernanda L
full_name: Perez Verdugo, Fernanda L
id: 4ecec223-9070-11ef-a0a9-bc76077bea8d
last_name: Perez Verdugo
- first_name: Nargess
full_name: Khalilgharibi, Nargess
last_name: Khalilgharibi
- first_name: Yanlan
full_name: Mao, Yanlan
last_name: Mao
- first_name: Ivan
full_name: Palaia, Ivan
id: 9c805cd2-4b75-11ec-a374-db6dd0ed57fa
last_name: Palaia
orcid: ' 0000-0002-8843-9485 '
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
citation:
ama: Meadowcroft B, Sorichetti V, Ratajczyk E, et al. Nonequilibrium remodeling
of collagen IV networks in Silico. PRX Life. 2025;3. doi:10.1103/gdd5-rnh7
apa: Meadowcroft, B., Sorichetti, V., Ratajczyk, E., Perez Verdugo, F. L., Khalilgharibi,
N., Mao, Y., … Šarić, A. (2025). Nonequilibrium remodeling of collagen IV networks
in Silico. PRX Life. American Physical Society. https://doi.org/10.1103/gdd5-rnh7
chicago: Meadowcroft, Billie, Valerio Sorichetti, Eryk Ratajczyk, Fernanda L Perez
Verdugo, Nargess Khalilgharibi, Yanlan Mao, Ivan Palaia, and Anđela Šarić. “Nonequilibrium
Remodeling of Collagen IV Networks in Silico.” PRX Life. American Physical
Society, 2025. https://doi.org/10.1103/gdd5-rnh7.
ieee: B. Meadowcroft et al., “Nonequilibrium remodeling of collagen IV networks
in Silico,” PRX Life, vol. 3. American Physical Society, 2025.
ista: Meadowcroft B, Sorichetti V, Ratajczyk E, Perez Verdugo FL, Khalilgharibi
N, Mao Y, Palaia I, Šarić A. 2025. Nonequilibrium remodeling of collagen IV networks
in Silico. PRX Life. 3, 033019.
mla: Meadowcroft, Billie, et al. “Nonequilibrium Remodeling of Collagen IV Networks
in Silico.” PRX Life, vol. 3, 033019, American Physical Society, 2025,
doi:10.1103/gdd5-rnh7.
short: B. Meadowcroft, V. Sorichetti, E. Ratajczyk, F.L. Perez Verdugo, N. Khalilgharibi,
Y. Mao, I. Palaia, A. Šarić, PRX Life 3 (2025).
corr_author: '1'
date_created: 2026-02-16T15:55:03Z
date_published: 2025-09-05T00:00:00Z
date_updated: 2026-02-17T13:37:38Z
day: '05'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1103/gdd5-rnh7
ec_funded: 1
file:
- access_level: open_access
checksum: 04cae5231d97e533145c493880fadbd9
content_type: application/pdf
creator: dernst
date_created: 2026-02-17T13:36:01Z
date_updated: 2026-02-17T13:36:01Z
file_id: '21308'
file_name: 2025_PRXLife_Meadowcroft.pdf
file_size: 2277704
relation: main_file
success: 1
file_date_updated: 2026-02-17T13:36:01Z
has_accepted_license: '1'
intvolume: ' 3'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
project:
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
call_identifier: H2020
grant_number: '802960'
name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
- _id: 349b6ff1-11ca-11ed-8bc3-f006047c2eeb
name: EMBO Young Investigator Program - Andela Saric
publication: PRX Life
publication_identifier:
eissn:
- 2835-8279
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Nonequilibrium remodeling of collagen IV networks in Silico
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2025'
...
---
OA_place: repository
_id: '21427'
abstract:
- lang: eng
text: While tumor malignancy has been extensively studied under the prism of genetic
and epigenetic heterogeneity, tumor cell states also critically depend on reciprocal
interactions with the microenvironment. This raises the hitherto untested possibility
that heterogeneity of the untransformed tumor stroma can actively fuel malignant
progression. As biological heterogeneity is inherently difficult to control, we
adopted a reductionist approach and let tumor cells invade micro-engineered environments
harboring obstacles with precision-controlled geometry. We find that not only
the presence of obstacles, but more surprisingly their spatial disorder, causes
a drastic shift from a collective to a single-cell mode of invasion – comparable
in strength to cadherin loss. Combining live-imaging and perturbation experiments
with minimal biophysical modeling, we demonstrate that cell detachments result
both from local geometrical constraints and a global integration of spatial disorder
over time. We show that different types of microenvironments map onto different
universality classes of invasion dynamics - homogeneous substrates follow Kardar–Parisi–Zhang
(KPZ) scaling, while disordered ones exhibit exponents consistent with KPZ with
quenched disorder (KPZq). Our findings highlight generic physical principles for
how the mode of cancer cell invasion depends on environmental heterogeneity, with
potential implications to understand tumor evolution in vivo.
acknowledgement: "European Research Council, https://ror.org/0472cxd90, 101071793\r\nAustrian
Academy of Sciences, 26360"
article_processing_charge: No
author:
- first_name: Zuzana
full_name: Dunajova, Zuzana
id: 4B39F286-F248-11E8-B48F-1D18A9856A87
last_name: Dunajova
- first_name: Saren
full_name: Tasciyan, Saren
id: 4323B49C-F248-11E8-B48F-1D18A9856A87
last_name: Tasciyan
orcid: 0000-0003-1671-393X
- first_name: Juraj
full_name: Majek, Juraj
id: 3e6d9473-f38e-11ec-8ae0-c4e05a8aa9e1
last_name: Majek
- first_name: Jack
full_name: Merrin, Jack
id: 4515C308-F248-11E8-B48F-1D18A9856A87
last_name: Merrin
orcid: 0000-0001-5145-4609
- first_name: Erik
full_name: Sahai, Erik
last_name: Sahai
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
citation:
ama: Dunajova Z, Tasciyan S, Majek J, et al. Substrate heterogeneity promotes cancer
cell dissemination through interface roughening. doi:10.1101/2025.05.20.655037
apa: Dunajova, Z., Tasciyan, S., Majek, J., Merrin, J., Sahai, E., Sixt, M. K.,
& Hannezo, E. B. (n.d.). Substrate heterogeneity promotes cancer cell dissemination
through interface roughening. bioRxiv. https://doi.org/10.1101/2025.05.20.655037
chicago: Dunajova, Zuzana, Saren Tasciyan, Juraj Majek, Jack Merrin, Erik Sahai,
Michael K Sixt, and Edouard B Hannezo. “Substrate Heterogeneity Promotes Cancer
Cell Dissemination through Interface Roughening.” bioRxiv, n.d. https://doi.org/10.1101/2025.05.20.655037.
ieee: Z. Dunajova et al., “Substrate heterogeneity promotes cancer cell dissemination
through interface roughening.” bioRxiv.
ista: Dunajova Z, Tasciyan S, Majek J, Merrin J, Sahai E, Sixt MK, Hannezo EB. Substrate
heterogeneity promotes cancer cell dissemination through interface roughening.
10.1101/2025.05.20.655037.
mla: Dunajova, Zuzana, et al. Substrate Heterogeneity Promotes Cancer Cell Dissemination
through Interface Roughening. bioRxiv, doi:10.1101/2025.05.20.655037.
short: Z. Dunajova, S. Tasciyan, J. Majek, J. Merrin, E. Sahai, M.K. Sixt, E.B.
Hannezo, (n.d.).
corr_author: '1'
date_created: 2026-03-11T08:40:06Z
date_published: 2025-09-25T00:00:00Z
date_updated: 2026-06-10T09:41:11Z
day: '25'
ddc:
- '539'
- '570'
department:
- _id: GradSch
- _id: EdHa
- _id: MiSi
- _id: NanoFab
- _id: AnSa
doi: 10.1101/2025.05.20.655037
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2025.05.20.655037
month: '09'
oa: 1
oa_version: Preprint
project:
- _id: bd91e723-d553-11ed-ba76-fe7eeb2185fd
grant_number: '101071793'
name: 'Pushing from within: Control of cell shape, integrity and motility by cytoskeletal
pushing forces'
- _id: 34d75525-11ca-11ed-8bc3-89b6307fee9d
grant_number: '26360'
name: Motile active matter models of migrating cells and chiral filaments
publication_status: draft
publisher: bioRxiv
related_material:
record:
- id: '21423'
relation: dissertation_contains
status: public
- id: '21439'
relation: research_data
status: public
status: public
title: Substrate heterogeneity promotes cancer cell dissemination through interface
roughening
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: preprint
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2025'
...
---
_id: '18072'
abstract:
- lang: eng
text: The individualization of chromosomes during early mitosis and their clustering
upon exit from cell division are two key transitions that ensure efficient segregation
of eukaryotic chromosomes. Both processes are regulated by the surfactant-like
protein Ki-67, but how Ki-67 achieves these diametric functions has remained unknown.
Here, we report that Ki-67 radically switches from a chromosome repellent to a
chromosome attractant during anaphase in human cells. We show that Ki-67 dephosphorylation
during mitotic exit and the simultaneous exposure of a conserved basic patch induce
the RNA-dependent formation of a liquid-like condensed phase on the chromosome
surface. Experiments and coarse-grained simulations support a model in which the
coalescence of chromosome surfaces, driven by co-condensation of Ki-67 and RNA,
promotes clustering of chromosomes. Our study reveals how the switch of Ki-67
from a surfactant to a liquid-like condensed phase can generate mechanical forces
during genome segregation that are required for re-establishing nuclear-cytoplasmic
compartmentalization after mitosis.
acknowledgement: We thank Daniel W. Gerlich for providing cell lines, the EMBL Advanced
Light Microscopy Facility (ALMF) for support, Christian H. Haering and Thomas Quail
for input on the manuscript, and Martina Dees for cloning several Ki-67 constructs.
This work was supported by the German Research Foundation (DFG project number 402723784)
and the Human Frontier Science Program (CDA00045/2019). A.H.-A. and A.B. have received
PhD fellowships from the Boehringer Ingelheim Fonds, V.S. and A.Š. were supported
by the European Research Council (ERC) under the European Union’s Horizon 2020 research
and innovation programme (grant no. 802960), and Y.H. was supported by a fellowship
from the EMBL interdisciplinary Postdoc (EIPOD) program (Marie Sklodowska-Curie
Actions, COFUND grant agreement 664726).
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Alberto
full_name: Hernandez-Armendariz, Alberto
last_name: Hernandez-Armendariz
- first_name: Valerio
full_name: Sorichetti, Valerio
id: ef8a92cb-c7b6-11ec-8bea-e1fd5847bc5b
last_name: Sorichetti
orcid: 0000-0002-9645-6576
- first_name: Yuki
full_name: Hayashi, Yuki
last_name: Hayashi
- first_name: Zuzana
full_name: Koskova, Zuzana
last_name: Koskova
- first_name: Andreas
full_name: Brunner, Andreas
last_name: Brunner
- first_name: Jan
full_name: Ellenberg, Jan
last_name: Ellenberg
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Sara
full_name: Cuylen-Haering, Sara
last_name: Cuylen-Haering
citation:
ama: Hernandez-Armendariz A, Sorichetti V, Hayashi Y, et al. A liquid-like coat
mediates chromosome clustering during mitotic exit. Molecular Cell. 2024;84(17):P3254-3270.E9.
doi:10.1016/j.molcel.2024.07.022
apa: Hernandez-Armendariz, A., Sorichetti, V., Hayashi, Y., Koskova, Z., Brunner,
A., Ellenberg, J., … Cuylen-Haering, S. (2024). A liquid-like coat mediates chromosome
clustering during mitotic exit. Molecular Cell. Cell Press. https://doi.org/10.1016/j.molcel.2024.07.022
chicago: Hernandez-Armendariz, Alberto, Valerio Sorichetti, Yuki Hayashi, Zuzana
Koskova, Andreas Brunner, Jan Ellenberg, Anđela Šarić, and Sara Cuylen-Haering.
“A Liquid-like Coat Mediates Chromosome Clustering during Mitotic Exit.” Molecular
Cell. Cell Press, 2024. https://doi.org/10.1016/j.molcel.2024.07.022.
ieee: A. Hernandez-Armendariz et al., “A liquid-like coat mediates chromosome
clustering during mitotic exit,” Molecular Cell, vol. 84, no. 17. Cell
Press, p. P3254–3270.E9, 2024.
ista: Hernandez-Armendariz A, Sorichetti V, Hayashi Y, Koskova Z, Brunner A, Ellenberg
J, Šarić A, Cuylen-Haering S. 2024. A liquid-like coat mediates chromosome clustering
during mitotic exit. Molecular Cell. 84(17), P3254–3270.E9.
mla: Hernandez-Armendariz, Alberto, et al. “A Liquid-like Coat Mediates Chromosome
Clustering during Mitotic Exit.” Molecular Cell, vol. 84, no. 17, Cell
Press, 2024, p. P3254–3270.E9, doi:10.1016/j.molcel.2024.07.022.
short: A. Hernandez-Armendariz, V. Sorichetti, Y. Hayashi, Z. Koskova, A. Brunner,
J. Ellenberg, A. Šarić, S. Cuylen-Haering, Molecular Cell 84 (2024) P3254–3270.E9.
date_created: 2024-09-15T22:01:41Z
date_published: 2024-09-05T00:00:00Z
date_updated: 2025-09-08T09:23:02Z
day: '05'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1016/j.molcel.2024.07.022
ec_funded: 1
external_id:
isi:
- '001309051100001'
pmid:
- '39153474'
file:
- access_level: open_access
checksum: 3f360e0287b8ec79fb2b8b02b5070360
content_type: application/pdf
creator: dernst
date_created: 2024-09-16T07:38:38Z
date_updated: 2024-09-16T07:38:38Z
file_id: '18075'
file_name: 2024_MolecularCell_HernandezArmendariz.pdf
file_size: 11654644
relation: main_file
success: 1
file_date_updated: 2024-09-16T07:38:38Z
has_accepted_license: '1'
intvolume: ' 84'
isi: 1
issue: '17'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: P3254-3270.E9
pmid: 1
project:
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
call_identifier: H2020
grant_number: '802960'
name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
publication: Molecular Cell
publication_identifier:
eissn:
- 1097-4164
issn:
- 1097-2765
publication_status: published
publisher: Cell Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: A liquid-like coat mediates chromosome clustering during mitotic exit
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 84
year: '2024'
...
---
OA_place: publisher
OA_type: hybrid
_id: '18526'
abstract:
- lang: eng
text: Multivesicular endosomes (MVEs) sequester membrane proteins destined for degradation
within intralumenal vesicles (ILVs), a process mediated by the membrane-remodeling
action of Endosomal Sorting Complex Required for Transport (ESCRT) proteins. In
Arabidopsis, endosomal membrane constriction and scission are uncoupled, resulting
in the formation of extensive concatenated ILV networks and enhancing cargo sequestration
efficiency. Here, we used a combination of electron tomography, computer simulations,
and mathematical modeling to address the questions of when concatenated ILV networks
evolved in plants and what drives their formation. Through morphometric analyses
of tomographic reconstructions of endosomes across yeast, algae, and various land
plants, we have found that ILV concatenation is widespread within plant species,
but only prevalent in seed plants, especially in flowering plants. Multiple budding
sites that require the formation of pores in the limiting membrane were only identified
in hornworts and seed plants, suggesting that this mechanism has evolved independently
in both plant lineages. To identify the conditions under which these multiple
budding sites can arise, we used particle-based molecular dynamics simulations
and found that changes in ESCRT filament properties, such as filament curvature
and membrane binding energy, can generate the membrane shapes observed in multiple
budding sites. To understand the relationship between membrane budding activity
and ILV network topology, we performed computational simulations and identified
a set of membrane remodeling parameters that can recapitulate our tomographic
datasets.
acknowledgement: We would like to thank Janice Pennington for her support with electron
tomography data collection, Dr. Ingrid Jordon-Thaden, director of the Botany Garden
and Greenhouse of University of Wisconsin Madison, for her invaluable assistance
collecting plant materials, Dr. Marie Trest for providing Chara specimens, and Dr.
Nicholas Keuler for his advice on statistical analyses. We thank Charlie Hamilton
for exploring the initial computational model. This work was supported by grant
NSF MCB 2114603 and NIH 1S10OD026769-01 to M.S.O. F.F acknowledges support as a
NOMIS Fellow from the NOMIS Foundation. A.Š. acknowledges ERC Starting Grant “NEPA”
802960.
article_number: e2409407121
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Ethan
full_name: Weiner, Ethan
last_name: Weiner
- first_name: Elizabeth
full_name: Berryman, Elizabeth
last_name: Berryman
- first_name: Felix F
full_name: Frey, Felix F
id: a0270b37-8f1a-11ec-95c7-8e710c59a4f3
last_name: Frey
orcid: 0000-0001-8501-6017
- first_name: Ariadna González
full_name: Solís, Ariadna González
last_name: Solís
- first_name: André
full_name: Leier, André
last_name: Leier
- first_name: Tatiana Marquez
full_name: Lago, Tatiana Marquez
last_name: Lago
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Marisa S.
full_name: Otegui, Marisa S.
last_name: Otegui
citation:
ama: Weiner E, Berryman E, Frey FF, et al. Endosomal membrane budding patterns in
plants. Proceedings of the National Academy of Sciences of the United States
of America. 2024;121(44). doi:10.1073/pnas.2409407121
apa: Weiner, E., Berryman, E., Frey, F. F., Solís, A. G., Leier, A., Lago, T. M.,
… Otegui, M. S. (2024). Endosomal membrane budding patterns in plants. Proceedings
of the National Academy of Sciences of the United States of America. National
Academy of Sciences. https://doi.org/10.1073/pnas.2409407121
chicago: Weiner, Ethan, Elizabeth Berryman, Felix F Frey, Ariadna González Solís,
André Leier, Tatiana Marquez Lago, Anđela Šarić, and Marisa S. Otegui. “Endosomal
Membrane Budding Patterns in Plants.” Proceedings of the National Academy of
Sciences of the United States of America. National Academy of Sciences, 2024.
https://doi.org/10.1073/pnas.2409407121.
ieee: E. Weiner et al., “Endosomal membrane budding patterns in plants,”
Proceedings of the National Academy of Sciences of the United States of America,
vol. 121, no. 44. National Academy of Sciences, 2024.
ista: Weiner E, Berryman E, Frey FF, Solís AG, Leier A, Lago TM, Šarić A, Otegui
MS. 2024. Endosomal membrane budding patterns in plants. Proceedings of the National
Academy of Sciences of the United States of America. 121(44), e2409407121.
mla: Weiner, Ethan, et al. “Endosomal Membrane Budding Patterns in Plants.” Proceedings
of the National Academy of Sciences of the United States of America, vol.
121, no. 44, e2409407121, National Academy of Sciences, 2024, doi:10.1073/pnas.2409407121.
short: E. Weiner, E. Berryman, F.F. Frey, A.G. Solís, A. Leier, T.M. Lago, A. Šarić,
M.S. Otegui, Proceedings of the National Academy of Sciences of the United States
of America 121 (2024).
date_created: 2024-11-10T23:01:59Z
date_published: 2024-10-29T00:00:00Z
date_updated: 2025-09-08T14:38:35Z
day: '29'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1073/pnas.2409407121
ec_funded: 1
external_id:
isi:
- '001349500800007'
pmid:
- '39441629'
file:
- access_level: open_access
checksum: 21c82d2ab58ff99b2bd0489797be42e5
content_type: application/pdf
creator: dernst
date_created: 2024-11-11T09:35:15Z
date_updated: 2024-11-11T09:35:15Z
file_id: '18538'
file_name: 2024_PNAS_Weiner.pdf
file_size: 5268074
relation: main_file
success: 1
file_date_updated: 2024-11-11T09:35:15Z
has_accepted_license: '1'
intvolume: ' 121'
isi: 1
issue: '44'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
call_identifier: H2020
grant_number: '802960'
name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
publication: Proceedings of the National Academy of Sciences of the United States
of America
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Endosomal membrane budding patterns in plants
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 121
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '18704'
abstract:
- lang: eng
text: Clathrin-mediated endocytosis is the main pathway used by eukaryotic cells
to take up extracellular material, but the dominant physical mechanisms driving
this process are still elusive. Recently, several high-resolution imaging techniques
have been used on different cell lines to measure the geometrical properties of
clathrin-coated pits over their whole lifetime. Here, we first show that the combination
of all datasets with the recently introduced cooperative curvature model defines
a consensus pathway, which is characterized by a flat-to-curved transition at
finite area, followed by linear growth and subsequent saturation of curvature.
We then apply an energetic model for the composite of the plasma membrane and
clathrin coat to this consensus pathway to show that the dominant mechanism for
invagination could be coat stiffening, which might originate from cooperative
interactions between the different clathrin molecules and progressively drives
the system toward its intrinsic curvature. Our theory predicts that two length
scales determine the invagination pathway, namely the patch size at which the
flat-to-curved transition occurs and the final pit radius.
acknowledgement: We thank Markus Mund, Aline Tschanz, and Jonas Ries for helpful discussions
and a critical reading of the manuscript. We also kindly acknowledge Simon Scheuring
for providing the HS-AFM data for the analysis of clathrin coat invagination. We
thank the reviewers of previous versions of this manuscript for useful feedback
that helped us to improve this work. F.F. acknowledges financial support by the
NOMIS foundation. U.S.S. was supported by the Deutsche Forschungsgemeinschaft (DFG,
German Research Foundation) under Project No. 240245660 (SFB 1129). Moreover, he
is a member of the Interdisciplinary Center for Scientific Computing (IWR) at Heidelberg
and of the Max Planck School Matter to Life supported by the German Federal Ministry
of Education and Research (BMBF) in collaboration with the Max Planck Society.
article_number: '064403'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Felix F
full_name: Frey, Felix F
id: a0270b37-8f1a-11ec-95c7-8e710c59a4f3
last_name: Frey
orcid: 0000-0001-8501-6017
- first_name: Ulrich S.
full_name: Schwarz, Ulrich S.
last_name: Schwarz
citation:
ama: Frey FF, Schwarz US. Coat stiffening can explain invagination of clathrin-coated
membranes. Physical Review E. 2024;110(6). doi:10.1103/PhysRevE.110.064403
apa: Frey, F. F., & Schwarz, U. S. (2024). Coat stiffening can explain invagination
of clathrin-coated membranes. Physical Review E. American Physical Society.
https://doi.org/10.1103/PhysRevE.110.064403
chicago: Frey, Felix F, and Ulrich S. Schwarz. “Coat Stiffening Can Explain Invagination
of Clathrin-Coated Membranes.” Physical Review E. American Physical Society,
2024. https://doi.org/10.1103/PhysRevE.110.064403.
ieee: F. F. Frey and U. S. Schwarz, “Coat stiffening can explain invagination of
clathrin-coated membranes,” Physical Review E, vol. 110, no. 6. American
Physical Society, 2024.
ista: Frey FF, Schwarz US. 2024. Coat stiffening can explain invagination of clathrin-coated
membranes. Physical Review E. 110(6), 064403.
mla: Frey, Felix F., and Ulrich S. Schwarz. “Coat Stiffening Can Explain Invagination
of Clathrin-Coated Membranes.” Physical Review E, vol. 110, no. 6, 064403,
American Physical Society, 2024, doi:10.1103/PhysRevE.110.064403.
short: F.F. Frey, U.S. Schwarz, Physical Review E 110 (2024).
date_created: 2024-12-22T23:01:48Z
date_published: 2024-12-10T00:00:00Z
date_updated: 2025-09-09T11:56:34Z
day: '10'
department:
- _id: AnSa
doi: 10.1103/PhysRevE.110.064403
external_id:
arxiv:
- '2405.02820'
isi:
- '001379135100004'
pmid:
- '39916158'
intvolume: ' 110'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2405.02820
month: '12'
oa: 1
oa_version: Preprint
pmid: 1
publication: Physical Review E
publication_identifier:
eissn:
- 2470-0053
issn:
- 2470-0045
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Coat stiffening can explain invagination of clathrin-coated membranes
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 110
year: '2024'
...
---
_id: '14844'
abstract:
- lang: eng
text: 'Many cell functions require a concerted effort from multiple membrane proteins,
for example, for signaling, cell division, and endocytosis. One contribution to
their successful self-organization stems from the membrane deformations that these
proteins induce. While the pairwise interaction potential of two membrane-deforming
spheres has recently been measured, membrane-deformation-induced interactions
have been predicted to be nonadditive, and hence their collective behavior cannot
be deduced from this measurement. We here employ a colloidal model system consisting
of adhesive spheres and giant unilamellar vesicles to test these predictions by
measuring the interaction potential of the simplest case of three membrane-deforming,
spherical particles. We quantify their interactions and arrangements and, for
the first time, experimentally confirm and quantify the nonadditive nature of
membrane-deformation-induced interactions. We furthermore conclude that there
exist two favorable configurations on the membrane: (1) a linear and (2) a triangular
arrangement of the three spheres. Using Monte Carlo simulations, we corroborate
the experimentally observed energy minima and identify a lowering of the membrane
deformation as the cause for the observed configurations. The high symmetry of
the preferred arrangements for three particles suggests that arrangements of many
membrane-deforming objects might follow simple rules.'
acknowledgement: We gratefully acknowledge useful discussions with Casper van der
Wel, help by Yogesh Shelke with PAA coverslip preparation, and support by Rachel
Doherty with particle functionalization. A.A. and D.J.K. would like to thank Timon
Idema and George Dadunashvili for initial attempts to simulate the experimental
system. D.J.K. would like to thank the physics department at Leiden University for
funding the PhD position of A.A. B.M. and A.Š. acknowledge funding by the European
Union’s Horizon 2020 research and innovation programme (ERC starting grant no. 802960).
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Ali
full_name: Azadbakht, Ali
last_name: Azadbakht
- first_name: Billie
full_name: Meadowcroft, Billie
id: a4725fd6-932b-11ed-81e2-c098c7f37ae1
last_name: Meadowcroft
orcid: 0000-0003-3441-1337
- first_name: Juraj
full_name: Majek, Juraj
id: 3e6d9473-f38e-11ec-8ae0-c4e05a8aa9e1
last_name: Majek
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Daniela J.
full_name: Kraft, Daniela J.
last_name: Kraft
citation:
ama: Azadbakht A, Meadowcroft B, Majek J, Šarić A, Kraft DJ. Nonadditivity in interactions
between three membrane-wrapped colloidal spheres. Biophysical Journal.
2024;123(3):307-316. doi:10.1016/j.bpj.2023.12.020
apa: Azadbakht, A., Meadowcroft, B., Majek, J., Šarić, A., & Kraft, D. J. (2024).
Nonadditivity in interactions between three membrane-wrapped colloidal spheres.
Biophysical Journal. Elsevier. https://doi.org/10.1016/j.bpj.2023.12.020
chicago: Azadbakht, Ali, Billie Meadowcroft, Juraj Majek, Anđela Šarić, and Daniela
J. Kraft. “Nonadditivity in Interactions between Three Membrane-Wrapped Colloidal
Spheres.” Biophysical Journal. Elsevier, 2024. https://doi.org/10.1016/j.bpj.2023.12.020.
ieee: A. Azadbakht, B. Meadowcroft, J. Majek, A. Šarić, and D. J. Kraft, “Nonadditivity
in interactions between three membrane-wrapped colloidal spheres,” Biophysical
Journal, vol. 123, no. 3. Elsevier, pp. 307–316, 2024.
ista: Azadbakht A, Meadowcroft B, Majek J, Šarić A, Kraft DJ. 2024. Nonadditivity
in interactions between three membrane-wrapped colloidal spheres. Biophysical
Journal. 123(3), 307–316.
mla: Azadbakht, Ali, et al. “Nonadditivity in Interactions between Three Membrane-Wrapped
Colloidal Spheres.” Biophysical Journal, vol. 123, no. 3, Elsevier, 2024,
pp. 307–16, doi:10.1016/j.bpj.2023.12.020.
short: A. Azadbakht, B. Meadowcroft, J. Majek, A. Šarić, D.J. Kraft, Biophysical
Journal 123 (2024) 307–316.
date_created: 2024-01-21T23:00:56Z
date_published: 2024-02-06T00:00:00Z
date_updated: 2025-09-04T11:46:15Z
day: '06'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1016/j.bpj.2023.12.020
ec_funded: 1
external_id:
isi:
- '001185235900001'
pmid:
- '38158654'
file:
- access_level: open_access
checksum: 1c8fe1cf950394875b65b90da86428ff
content_type: application/pdf
creator: dernst
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title: Nonadditivity in interactions between three membrane-wrapped colloidal spheres
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