[{"acknowledgement":"We acknowledge K. Kubiasová for excellent technical assistance, J. Neuhold, A. Lehner and A. Sedivy for technical assistance with protein production and purification at Vienna Biocenter Core Facilities; Creoptix for performing GCI; and the Bioimaging, Electron Microscopy and Life Science Facilities at ISTA, the Plant Sciences Core Facility of CEITEC Masaryk University, the Core Facility CELLIM (MEYS CR, LM2018129 Czech-BioImaging) and J. Sprakel for their assistance. J.F. is grateful to R. Napier for many insightful suggestions and support. We thank all past and present members of the Friml group for their support and for other contributions to this effort to clarify the controversial role of ABP1 over the past seven years. The project received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement no. 742985 to J.F. and 833867 to D.W.); the Austrian Science Fund (FWF; P29988 to J.F.); the Netherlands Organization for Scientific Research (NWO; VICI grant 865.14.001 to D.W. and VENI grant VI.Veni.212.003 to A.K.); the Ministry of Education, Science and Technological Development of the Republic of Serbia (contract no. 451-03-68/2022-14/200053 to B.D.Ž.); and the MEXT/JSPS KAKENHI to K.T. (20K06685) and T.K. (20H05687 and 20H05910).","scopus_import":"1","status":"public","file":[{"file_id":"14483","date_created":"2023-11-02T17:12:37Z","file_name":"Friml Nature 2022_merged.pdf","date_updated":"2023-11-02T17:12:37Z","file_size":79774945,"creator":"amally","success":1,"access_level":"open_access","content_type":"application/pdf","relation":"main_file","checksum":"a6055c606aefb900bf62ae3e7d15f921"}],"citation":{"ista":"Friml J, Gallei MC, Gelová Z, Johnson AJ, Mazur E, Monzer A, Rodriguez Solovey L, Roosjen M, Verstraeten I, Živanović BD, Zou M, Fiedler L, Giannini C, Grones P, Hrtyan M, Kaufmann W, Kuhn A, Narasimhan M, Randuch M, Rýdza N, Takahashi K, Tan S, Teplova A, Kinoshita T, Weijers D, Rakusová H. 2022. ABP1–TMK auxin perception for global phosphorylation and auxin canalization. Nature. 609(7927), 575–581.","chicago":"Friml, Jiří, Michelle C Gallei, Zuzana Gelová, Alexander J Johnson, Ewa Mazur, Aline Monzer, Lesia Rodriguez Solovey, et al. “ABP1–TMK Auxin Perception for Global Phosphorylation and Auxin Canalization.” Nature. Springer Nature, 2022. https://doi.org/10.1038/s41586-022-05187-x.","short":"J. Friml, M.C. Gallei, Z. Gelová, A.J. Johnson, E. Mazur, A. Monzer, L. Rodriguez Solovey, M. Roosjen, I. Verstraeten, B.D. Živanović, M. Zou, L. Fiedler, C. Giannini, P. Grones, M. Hrtyan, W. Kaufmann, A. Kuhn, M. Narasimhan, M. Randuch, N. Rýdza, K. Takahashi, S. Tan, A. Teplova, T. Kinoshita, D. Weijers, H. Rakusová, Nature 609 (2022) 575–581.","mla":"Friml, Jiří, et al. “ABP1–TMK Auxin Perception for Global Phosphorylation and Auxin Canalization.” Nature, vol. 609, no. 7927, Springer Nature, 2022, pp. 575–81, doi:10.1038/s41586-022-05187-x.","apa":"Friml, J., Gallei, M. C., Gelová, Z., Johnson, A. J., Mazur, E., Monzer, A., … Rakusová, H. (2022). ABP1–TMK auxin perception for global phosphorylation and auxin canalization. Nature. Springer Nature. https://doi.org/10.1038/s41586-022-05187-x","ama":"Friml J, Gallei MC, Gelová Z, et al. ABP1–TMK auxin perception for global phosphorylation and auxin canalization. Nature. 2022;609(7927):575-581. doi:10.1038/s41586-022-05187-x","ieee":"J. Friml et al., “ABP1–TMK auxin perception for global phosphorylation and auxin canalization,” Nature, vol. 609, no. 7927. Springer Nature, pp. 575–581, 2022."},"acknowledged_ssus":[{"_id":"Bio"},{"_id":"EM-Fac"},{"_id":"LifeSc"}],"language":[{"iso":"eng"}],"quality_controlled":"1","oa_version":"Submitted Version","corr_author":"1","month":"09","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"19395"},{"id":"20364","relation":"dissertation_contains","status":"public"}]},"ec_funded":1,"doi":"10.1038/s41586-022-05187-x","day":"15","publication_status":"published","department":[{"_id":"JiFr"},{"_id":"GradSch"},{"_id":"EvBe"},{"_id":"EM-Fac"}],"file_date_updated":"2023-11-02T17:12:37Z","date_updated":"2026-04-07T11:52:15Z","type":"journal_article","abstract":[{"lang":"eng","text":"The phytohormone auxin triggers transcriptional reprogramming through a well-characterized perception machinery in the nucleus. By contrast, mechanisms that underlie fast effects of auxin, such as the regulation of ion fluxes, rapid phosphorylation of proteins or auxin feedback on its transport, remain unclear1,2,3. Whether auxin-binding protein 1 (ABP1) is an auxin receptor has been a source of debate for decades1,4. Here we show that a fraction of Arabidopsis thaliana ABP1 is secreted and binds auxin specifically at an acidic pH that is typical of the apoplast. ABP1 and its plasma-membrane-localized partner, transmembrane kinase 1 (TMK1), are required for the auxin-induced ultrafast global phospho-response and for downstream processes that include the activation of H+-ATPase and accelerated cytoplasmic streaming. abp1 and tmk mutants cannot establish auxin-transporting channels and show defective auxin-induced vasculature formation and regeneration. An ABP1(M2X) variant that lacks the capacity to bind auxin is unable to complement these defects in abp1 mutants. These data indicate that ABP1 is the auxin receptor for TMK1-based cell-surface signalling, which mediates the global phospho-response and auxin canalization."}],"publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"publication":"Nature","date_created":"2023-01-16T10:04:48Z","has_accepted_license":"1","oa":1,"article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"ABP1–TMK auxin perception for global phosphorylation and auxin canalization","year":"2022","publisher":"Springer Nature","project":[{"_id":"261099A6-B435-11E9-9278-68D0E5697425","name":"Tracing Evolution of Auxin Transport and Polarity in Plants","call_identifier":"H2020","grant_number":"742985"},{"_id":"262EF96E-B435-11E9-9278-68D0E5697425","grant_number":"P29988","name":"RNA-directed DNA methylation in plant development","call_identifier":"FWF"}],"ddc":["580"],"article_processing_charge":"No","page":"575-581","date_published":"2022-09-15T00:00:00Z","pmid":1,"volume":609,"intvolume":" 609","author":[{"last_name":"Friml","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","first_name":"Jiří"},{"orcid":"0000-0003-1286-7368","first_name":"Michelle C","full_name":"Gallei, Michelle C","id":"35A03822-F248-11E8-B48F-1D18A9856A87","last_name":"Gallei"},{"last_name":"Gelová","id":"0AE74790-0E0B-11E9-ABC7-1ACFE5697425","full_name":"Gelová, Zuzana","first_name":"Zuzana","orcid":"0000-0003-4783-1752"},{"last_name":"Johnson","full_name":"Johnson, Alexander J","id":"46A62C3A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2739-8843","first_name":"Alexander J"},{"full_name":"Mazur, Ewa","last_name":"Mazur","first_name":"Ewa"},{"first_name":"Aline","full_name":"Monzer, Aline","id":"2DB5D88C-D7B3-11E9-B8FD-7907E6697425","last_name":"Monzer"},{"first_name":"Lesia","orcid":"0000-0002-7244-7237","last_name":"Rodriguez Solovey","id":"3922B506-F248-11E8-B48F-1D18A9856A87","full_name":"Rodriguez Solovey, Lesia"},{"first_name":"Mark","full_name":"Roosjen, Mark","last_name":"Roosjen"},{"orcid":"0000-0001-7241-2328","first_name":"Inge","full_name":"Verstraeten, Inge","id":"362BF7FE-F248-11E8-B48F-1D18A9856A87","last_name":"Verstraeten"},{"first_name":"Branka D.","full_name":"Živanović, Branka D.","last_name":"Živanović"},{"first_name":"Minxia","last_name":"Zou","id":"5c243f41-03f3-11ec-841c-96faf48a7ef9","full_name":"Zou, Minxia"},{"first_name":"Lukas","last_name":"Fiedler","full_name":"Fiedler, Lukas","id":"7c417475-8972-11ed-ae7b-8b674ca26986"},{"first_name":"Caterina","last_name":"Giannini","id":"e3fdddd5-f6e0-11ea-865d-ca99ee6367f4","full_name":"Giannini, Caterina"},{"last_name":"Grones","full_name":"Grones, Peter","first_name":"Peter"},{"first_name":"Mónika","last_name":"Hrtyan","id":"45A71A74-F248-11E8-B48F-1D18A9856A87","full_name":"Hrtyan, Mónika"},{"id":"3F99E422-F248-11E8-B48F-1D18A9856A87","full_name":"Kaufmann, Walter","last_name":"Kaufmann","first_name":"Walter","orcid":"0000-0001-9735-5315"},{"first_name":"Andre","last_name":"Kuhn","full_name":"Kuhn, Andre"},{"orcid":"0000-0002-8600-0671","first_name":"Madhumitha","last_name":"Narasimhan","full_name":"Narasimhan, Madhumitha","id":"44BF24D0-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Randuch","full_name":"Randuch, Marek","id":"6ac4636d-15b2-11ec-abd3-fb8df79972ae","first_name":"Marek"},{"first_name":"Nikola","last_name":"Rýdza","full_name":"Rýdza, Nikola"},{"first_name":"Koji","full_name":"Takahashi, Koji","last_name":"Takahashi"},{"orcid":"0000-0002-0471-8285","first_name":"Shutang","last_name":"Tan","full_name":"Tan, Shutang","id":"2DE75584-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Teplova","id":"e3736151-106c-11ec-b916-c2558e2762c6","full_name":"Teplova, Anastasiia","first_name":"Anastasiia"},{"first_name":"Toshinori","full_name":"Kinoshita, Toshinori","last_name":"Kinoshita"},{"full_name":"Weijers, Dolf","last_name":"Weijers","first_name":"Dolf"},{"full_name":"Rakusová, Hana","last_name":"Rakusová","first_name":"Hana"}],"isi":1,"_id":"12291","issue":"7927","external_id":{"pmid":["36071161"],"isi":["000851357500002"]}},{"intvolume":" 32","volume":32,"issue":"5","_id":"12307","author":[{"last_name":"Shipman","full_name":"Shipman, Barbara A.","first_name":"Barbara A."},{"first_name":"Elizabeth R","orcid":"0000-0002-6862-208X","id":"2D04F932-F248-11E8-B48F-1D18A9856A87","full_name":"Stephenson, Elizabeth R","last_name":"Stephenson"}],"publisher":"Taylor & Francis","year":"2022","date_published":"2022-05-28T00:00:00Z","article_processing_charge":"No","page":"593-609","abstract":[{"text":"Point-set topology is among the most abstract branches of mathematics in that it lacks tangible notions of distance, length, magnitude, order, and size. There is no shape, no geometry, no algebra, and no direction. Everything we are used to visualizing is gone. In the teaching and learning of mathematics, this can present a conundrum. Yet, this very property makes point set topology perfect for teaching and learning abstract mathematical concepts. It clears our minds of preconceived intuitions and expectations and forces us to think in new and creative ways. In this paper, we present guided investigations into topology through questions and thinking strategies that open up fascinating problems. They are intended for faculty who already teach or are thinking about teaching a class in topology or abstract mathematical reasoning for undergraduates. They can be used to build simple to challenging projects in topology, proofs, honors programs, and research experiences.","lang":"eng"}],"publication_identifier":{"eissn":["1935-4053"],"issn":["1051-1970"]},"date_created":"2023-01-16T10:07:21Z","publication":"PRIMUS","date_updated":"2024-10-09T21:03:58Z","type":"journal_article","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Tangible topology through the lens of limits","keyword":["Education","General Mathematics"],"status":"public","citation":{"ieee":"B. A. Shipman and E. R. Stephenson, “Tangible topology through the lens of limits,” PRIMUS, vol. 32, no. 5. Taylor & Francis, pp. 593–609, 2022.","ama":"Shipman BA, Stephenson ER. Tangible topology through the lens of limits. PRIMUS. 2022;32(5):593-609. doi:10.1080/10511970.2021.1872750","apa":"Shipman, B. A., & Stephenson, E. R. (2022). Tangible topology through the lens of limits. PRIMUS. Taylor & Francis. https://doi.org/10.1080/10511970.2021.1872750","short":"B.A. Shipman, E.R. Stephenson, PRIMUS 32 (2022) 593–609.","mla":"Shipman, Barbara A., and Elizabeth R. Stephenson. “Tangible Topology through the Lens of Limits.” PRIMUS, vol. 32, no. 5, Taylor & Francis, 2022, pp. 593–609, doi:10.1080/10511970.2021.1872750.","chicago":"Shipman, Barbara A., and Elizabeth R Stephenson. “Tangible Topology through the Lens of Limits.” PRIMUS. Taylor & Francis, 2022. https://doi.org/10.1080/10511970.2021.1872750.","ista":"Shipman BA, Stephenson ER. 2022. Tangible topology through the lens of limits. PRIMUS. 32(5), 593–609."},"scopus_import":"1","corr_author":"1","month":"05","day":"28","doi":"10.1080/10511970.2021.1872750","department":[{"_id":"HeEd"},{"_id":"GradSch"}],"publication_status":"published","language":[{"iso":"eng"}],"oa_version":"None","quality_controlled":"1"},{"degree_awarded":"PhD","year":"2022","ddc":["000","620"],"publisher":"Institute of Science and Technology Austria","project":[{"grant_number":"638176","call_identifier":"H2020","name":"Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large Scales","_id":"2533E772-B435-11E9-9278-68D0E5697425"}],"page":"138","article_processing_charge":"No","date_published":"2022-09-22T00:00:00Z","author":[{"last_name":"Sperl","full_name":"Sperl, Georg","id":"4DD40360-F248-11E8-B48F-1D18A9856A87","first_name":"Georg"}],"_id":"12358","alternative_title":["ISTA Thesis"],"citation":{"short":"G. Sperl, Homogenizing Yarn Simulations: Large-Scale Mechanics, Small-Scale Detail, and Quantitative Fitting, Institute of Science and Technology Austria, 2022.","chicago":"Sperl, Georg. “Homogenizing Yarn Simulations: Large-Scale Mechanics, Small-Scale Detail, and Quantitative Fitting.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:12103.","mla":"Sperl, Georg. Homogenizing Yarn Simulations: Large-Scale Mechanics, Small-Scale Detail, and Quantitative Fitting. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:12103.","ista":"Sperl G. 2022. Homogenizing yarn simulations: Large-scale mechanics, small-scale detail, and quantitative fitting. Institute of Science and Technology Austria.","ieee":"G. Sperl, “Homogenizing yarn simulations: Large-scale mechanics, small-scale detail, and quantitative fitting,” Institute of Science and Technology Austria, 2022.","ama":"Sperl G. Homogenizing yarn simulations: Large-scale mechanics, small-scale detail, and quantitative fitting. 2022. doi:10.15479/at:ista:12103","apa":"Sperl, G. (2022). Homogenizing yarn simulations: Large-scale mechanics, small-scale detail, and quantitative fitting. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12103"},"file":[{"relation":"main_file","checksum":"083722acbb8115e52e3b0fdec6226769","content_type":"application/pdf","title":"Thesis","description":"This is the main PDF file of the thesis. File size: 105 MB","access_level":"open_access","file_size":104497530,"creator":"cchlebak","date_updated":"2023-02-02T09:29:57Z","file_name":"thesis_gsperl.pdf","file_id":"12371","date_created":"2023-01-25T12:04:41Z"},{"relation":"main_file","checksum":"511f82025e5fcb70bff4731d6896ca07","content_type":"application/pdf","title":"Thesis (compressed 23MB)","description":"This version of the thesis uses stronger image compression for a smaller file size of 23MB.","access_level":"open_access","file_size":23183710,"creator":"cchlebak","date_updated":"2023-02-02T09:33:37Z","file_name":"thesis_gsperl_compressed.pdf","file_id":"12483","date_created":"2023-02-02T09:33:37Z"},{"access_level":"open_access","content_type":"application/x-zip-compressed","relation":"source_file","checksum":"ed4cb85225eedff761c25bddfc37a2ed","file_id":"12484","date_created":"2023-02-02T09:39:25Z","file_name":"thesis-source.zip","date_updated":"2023-02-02T09:39:25Z","file_size":98382247,"creator":"cchlebak"}],"status":"public","oa_version":"Published Version","language":[{"iso":"eng"}],"acknowledged_ssus":[{"_id":"SSU"}],"ec_funded":1,"doi":"10.15479/at:ista:12103","day":"22","publication_status":"published","department":[{"_id":"GradSch"},{"_id":"ChWo"}],"month":"09","corr_author":"1","related_material":{"record":[{"status":"public","id":"8385","relation":"part_of_dissertation"},{"id":"11736","relation":"part_of_dissertation","status":"public"},{"relation":"part_of_dissertation","id":"9818","status":"public"}]},"date_updated":"2026-06-18T19:57:47Z","type":"dissertation","file_date_updated":"2023-02-02T09:39:25Z","publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-020-6"]},"supervisor":[{"full_name":"Wojtan, Christopher J","id":"3C61F1D2-F248-11E8-B48F-1D18A9856A87","last_name":"Wojtan","orcid":"0000-0001-6646-5546","first_name":"Christopher J"}],"date_created":"2023-01-24T10:49:46Z","abstract":[{"lang":"eng","text":"The complex yarn structure of knitted and woven fabrics gives rise to both a mechanical and\r\nvisual complexity. The small-scale interactions of yarns colliding with and pulling on each\r\nother result in drastically different large-scale stretching and bending behavior, introducing\r\nanisotropy, curling, and more. While simulating cloth as individual yarns can reproduce this\r\ncomplexity and match the quality of real fabric, it may be too computationally expensive for\r\nlarge fabrics. On the other hand, continuum-based approaches do not need to discretize the\r\ncloth at a stitch-level, but it is non-trivial to find a material model that would replicate the\r\nlarge-scale behavior of yarn fabrics, and they discard the intricate visual detail. In this thesis,\r\nwe discuss three methods to try and bridge the gap between small-scale and large-scale yarn\r\nmechanics using numerical homogenization: fitting a continuum model to periodic yarn simulations, adding mechanics-aware yarn detail onto thin-shell simulations, and quantitatively\r\nfitting yarn parameters to physical measurements of real fabric.\r\nTo start, we present a method for animating yarn-level cloth effects using a thin-shell solver.\r\nWe first use a large number of periodic yarn-level simulations to build a model of the potential\r\nenergy density of the cloth, and then use it to compute forces in a thin-shell simulator. The\r\nresulting simulations faithfully reproduce expected effects like the stiffening of woven fabrics\r\nand the highly deformable nature and anisotropy of knitted fabrics at a fraction of the cost of\r\nfull yarn-level simulation.\r\nWhile our thin-shell simulations are able to capture large-scale yarn mechanics, they lack\r\nthe rich visual detail of yarn-level simulations. Therefore, we propose a method to animate\r\nyarn-level cloth geometry on top of an underlying deforming mesh in a mechanics-aware\r\nfashion in real time. Using triangle strains to interpolate precomputed yarn geometry, we are\r\nable to reproduce effects such as knit loops tightening under stretching at negligible cost.\r\nFinally, we introduce a methodology for inverse-modeling of yarn-level mechanics of cloth,\r\nbased on the mechanical response of fabrics in the real world. We compile a database from\r\nphysical tests of several knitted fabrics used in the textile industry spanning diverse physical\r\nproperties like stiffness, nonlinearity, and anisotropy. We then develop a system for approximating these mechanical responses with yarn-level cloth simulation, using homogenized\r\nshell models to speed up computation and adding some small-but-necessary extensions to\r\nyarn-level models used in computer graphics.\r\n"}],"has_accepted_license":"1","oa":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","title":"Homogenizing yarn simulations: Large-scale mechanics, small-scale detail, and quantitative fitting","OA_place":"publisher"},{"year":"2022","degree_awarded":"PhD","ddc":["570"],"project":[{"call_identifier":"H2020","name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","grant_number":"742573","_id":"260F1432-B435-11E9-9278-68D0E5697425"}],"publisher":"Institute of Science and Technology Austria","page":"113","article_processing_charge":"No","date_published":"2022-09-29T00:00:00Z","author":[{"full_name":"Arslan, Feyza N","id":"49DA7910-F248-11E8-B48F-1D18A9856A87","last_name":"Arslan","orcid":"0000-0001-5809-9566","first_name":"Feyza N"}],"alternative_title":["ISTA Thesis"],"_id":"12368","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"citation":{"chicago":"Arslan, Feyza N. “Remodeling of E-Cadherin-Mediated Contacts via Cortical Flows.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:12153.","mla":"Arslan, Feyza N. Remodeling of E-Cadherin-Mediated Contacts via Cortical Flows. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:12153.","short":"F.N. Arslan, Remodeling of E-Cadherin-Mediated Contacts via Cortical Flows, Institute of Science and Technology Austria, 2022.","ista":"Arslan FN. 2022. Remodeling of E-cadherin-mediated contacts via cortical flows. Institute of Science and Technology Austria.","ieee":"F. N. Arslan, “Remodeling of E-cadherin-mediated contacts via cortical flows,” Institute of Science and Technology Austria, 2022.","ama":"Arslan FN. Remodeling of E-cadherin-mediated contacts via cortical flows. 2022. doi:10.15479/at:ista:12153","apa":"Arslan, F. N. (2022). Remodeling of E-cadherin-mediated contacts via cortical flows. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12153"},"file":[{"access_level":"open_access","success":1,"checksum":"e54a3e69b83ebf166544164afd25608e","relation":"main_file","content_type":"application/pdf","file_name":"THESIS_FINAL_FArslan_pdfa.pdf","file_id":"12369","date_created":"2023-01-25T10:52:46Z","creator":"cchlebak","file_size":14581024,"date_updated":"2023-01-25T10:52:46Z"}],"status":"public","language":[{"iso":"eng"}],"oa_version":"Published Version","acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"},{"_id":"NanoFab"}],"publication_status":"published","department":[{"_id":"GradSch"},{"_id":"CaHe"}],"doi":"10.15479/at:ista:12153","ec_funded":1,"day":"29","related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"9350"}]},"month":"09","corr_author":"1","type":"dissertation","date_updated":"2026-06-18T19:47:50Z","file_date_updated":"2023-01-25T10:52:46Z","supervisor":[{"last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J"}],"date_created":"2023-01-25T10:43:24Z","publication_identifier":{"isbn":["978-3-99078-025-1 "],"issn":["2663-337X"]},"abstract":[{"text":"Metazoan development relies on the formation and remodeling of cell-cell contacts. The \r\nbinding of adhesion receptors and remodeling of the actomyosin cell cortex at cell-cell \r\ninteraction sites have been implicated in cell-cell contact formation. Yet, how these two \r\nprocesses functionally interact to drive cell-cell contact expansion and strengthening \r\nremains unclear. Here, we study how primary germ layer progenitor cells from zebrafish \r\nbind to supported lipid bilayers (SLB) functionalized with E-cadherin ectodomains as an \r\nassay system for monitoring cell-cell contact formation at high spatiotemporal resolution. \r\nWe show that cell-cell contact formation represents a two-tiered process: E-cadherin\u0002mediated downregulation of the small GTPase RhoA at the forming contact leads to both \r\ndepletion of Myosin-2 and decrease of F-actin. This is followed by centrifugal actin \r\nnetwork flows at the contact triggered by a sharp gradient of Myosin-2 at the rim of the \r\ncontact zone, with Myosin-2 displaying higher cortical localization outside than inside of \r\nthe contact. These centrifugal cortical actin flows, in turn, not only further dilute the actin \r\nnetwork at the contact disc, but also lead to an accumulation of both F-actin and E\u0002cadherin at the contact rim. Eventually, this combination of actomyosin downregulation \r\nand flows at the contact contribute to the characteristic molecular organization implicated \r\nin contact formation and maintenance: depletion of cortical actomyosin at the contact disc, \r\ndriving contact expansion by lowering interfacial tension at the contact, and accumulation \r\nof both E-cadherin and F-actin at the contact rim, mechanically linking the contractile \r\ncortices of the adhering cells. Thus, using a biomimetic assay, we exemplify how \r\nadhesion signaling and cell mechanics function together to modulate the spatial \r\norganization of cell-cell contacts.","lang":"eng"}],"has_accepted_license":"1","oa":1,"title":"Remodeling of E-cadherin-mediated contacts via cortical flows","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","OA_place":"publisher"},{"article_processing_charge":"No","page":"196","date_published":"2022-12-15T00:00:00Z","year":"2022","degree_awarded":"PhD","project":[{"_id":"25C6DC12-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Analysis of quantum many-body systems","grant_number":"694227"}],"publisher":"Institute of Science and Technology Austria","ddc":["500"],"author":[{"orcid":"0000-0002-6249-0928","first_name":"Morris","full_name":"Brooks, Morris","id":"B7ECF9FC-AA38-11E9-AC9A-0930E6697425","last_name":"Brooks"}],"alternative_title":["ISTA Thesis"],"_id":"12390","language":[{"iso":"eng"}],"oa_version":"Published Version","related_material":{"record":[{"status":"public","id":"9005","relation":"part_of_dissertation"}]},"month":"12","corr_author":"1","publication_status":"published","department":[{"_id":"GradSch"},{"_id":"RoSe"}],"ec_funded":1,"doi":"10.15479/at:ista:12390","day":"15","status":"public","tmp":{"name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode"},"citation":{"ista":"Brooks M. 2022. Translation-invariant quantum systems with effectively broken symmetry. Institute of Science and Technology Austria.","short":"M. Brooks, Translation-Invariant Quantum Systems with Effectively Broken Symmetry, Institute of Science and Technology Austria, 2022.","mla":"Brooks, Morris. Translation-Invariant Quantum Systems with Effectively Broken Symmetry. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:12390.","chicago":"Brooks, Morris. “Translation-Invariant Quantum Systems with Effectively Broken Symmetry.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:12390.","ama":"Brooks M. Translation-invariant quantum systems with effectively broken symmetry. 2022. doi:10.15479/at:ista:12390","apa":"Brooks, M. (2022). Translation-invariant quantum systems with effectively broken symmetry. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12390","ieee":"M. Brooks, “Translation-invariant quantum systems with effectively broken symmetry,” Institute of Science and Technology Austria, 2022."},"file":[{"file_name":"Brooks_Thesis.pdf","date_created":"2023-01-26T10:02:34Z","file_id":"12391","file_size":3095225,"creator":"cchlebak","date_updated":"2023-01-26T10:02:34Z","success":1,"access_level":"open_access","relation":"main_file","checksum":"b31460e937f33b557abb40ebef02b567","content_type":"application/pdf"},{"date_created":"2023-01-26T10:02:42Z","file_id":"12392","file_name":"Brooks_Thesis.tex","date_updated":"2023-01-26T10:02:42Z","file_size":809842,"creator":"cchlebak","access_level":"closed","content_type":"application/octet-stream","relation":"source_file","checksum":"9751869fa5e7981588ad4228f4fd4bd6"}],"has_accepted_license":"1","oa":1,"OA_place":"publisher","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","title":"Translation-invariant quantum systems with effectively broken symmetry","file_date_updated":"2023-01-26T10:02:42Z","type":"dissertation","date_updated":"2026-04-16T08:20:52Z","abstract":[{"lang":"eng","text":"The scope of this thesis is to study quantum systems exhibiting a continuous symmetry that\r\nis broken on the level of the corresponding effective theory. In particular we are going to\r\ninvestigate translation-invariant Bose gases in the mean field limit, effectively described by\r\nthe Hartree functional, and the Fröhlich Polaron in the regime of strong coupling, effectively\r\ndescribed by the Pekar functional. The latter is a model describing the interaction between a\r\ncharged particle and the optical modes of a polar crystal. Regarding the former, we assume in\r\naddition that the particles in the gas are unconfined, and typically we will consider particles\r\nthat are subject to an attractive interaction. In both cases the ground state energy of the\r\nHamiltonian is not a proper eigenvalue due to the underlying translation-invariance, while on\r\nthe contrary there exists a whole invariant orbit of minimizers for the corresponding effective\r\nfunctionals. Both, the absence of proper eigenstates and the broken symmetry of the effective\r\ntheory, make the study significantly more involved and it is the content of this thesis to\r\ndevelop a frameworks which allows for a systematic way to circumvent these issues.\r\nIt is a well-established result that the ground state energy of Bose gases in the mean field limit,\r\nas well as the ground state energy of the Fröhlich Polaron in the regime of strong coupling, is\r\nto leading order given by the minimal energy of the corresponding effective theory. As part\r\nof this thesis we identify the sub-leading term in the expansion of the ground state energy,\r\nwhich can be interpreted as the quantum correction to the classical energy, since the effective\r\ntheories under consideration can be seen as classical counterparts.\r\nWe are further going to establish an asymptotic expression for the energy-momentum relation\r\nof the Fröhlich Polaron in the strong coupling limit. In the regime of suitably small momenta,\r\nthis asymptotic expression agrees with the energy-momentum relation of a free particle having\r\nan effectively increased mass, and we find that this effectively increased mass agrees with the\r\nconjectured value in the physics literature.\r\nIn addition we will discuss two unrelated papers written by the author during his stay at ISTA\r\nin the appendix. The first one concerns the realization of anyons, which are quasi-particles\r\nacquiring a non-trivial phase under the exchange of two particles, as molecular impurities.\r\nThe second one provides a classification of those vector fields defined on a given manifold\r\nthat can be written as the gradient of a given functional with respect to a suitable metric,\r\nprovided that some mild smoothness assumptions hold. This classification is subsequently\r\nused to identify those quantum Markov semigroups that can be written as a gradient flow of\r\nthe relative entropy.\r\n"}],"date_created":"2023-01-26T10:00:42Z","supervisor":[{"first_name":"Robert","orcid":"0000-0002-6781-0521","last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","full_name":"Seiringer, Robert"}],"publication_identifier":{"issn":["2663-337X"]}},{"oa":1,"author":[{"orcid":"0000-0002-4561-241X","first_name":"Krishnendu","last_name":"Chatterjee","full_name":"Chatterjee, Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Mona","last_name":"Mohammadi","full_name":"Mohammadi, Mona","id":"4363614d-b686-11ed-a7d5-ac9e4a24bc2e"},{"first_name":"Raimundo J","orcid":"0000-0001-5103-038X","last_name":"Saona Urmeneta","id":"BD1DF4C4-D767-11E9-B658-BC13E6697425","full_name":"Saona Urmeneta, Raimundo J"}],"_id":"12677","external_id":{"arxiv":["2209.14368"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Repeated prophet inequality with near-optimal bounds","date_updated":"2025-04-14T07:52:48Z","type":"preprint","date_created":"2023-02-24T12:21:40Z","publication":"arXiv","abstract":[{"lang":"eng","text":"In modern sample-driven Prophet Inequality, an adversary chooses a sequence of n items with values v1,v2,…,vn to be presented to a decision maker (DM). The process follows in two phases. In the first phase (sampling phase), some items, possibly selected at random, are revealed to the DM, but she can never accept them. In the second phase, the DM is presented with the other items in a random order and online fashion. For each item, she must make an irrevocable decision to either accept the item and stop the process or reject the item forever and proceed to the next item. The goal of the DM is to maximize the expected value as compared to a Prophet (or offline algorithm) that has access to all information. In this setting, the sampling phase has no cost and is not part of the optimization process. However, in many scenarios, the samples are obtained as part of the decision-making process.\r\nWe model this aspect as a two-phase Prophet Inequality where an adversary chooses a sequence of 2n items with values v1,v2,…,v2n and the items are randomly ordered. Finally, there are two phases of the Prophet Inequality problem with the first n-items and the rest of the items, respectively. We show that some basic algorithms achieve a ratio of at most 0.450. We present an algorithm that achieves a ratio of at least 0.495. Finally, we show that for every algorithm the ratio it can achieve is at most 0.502. Hence our algorithm is near-optimal."}],"oa_version":"Preprint","language":[{"iso":"eng"}],"article_processing_charge":"No","arxiv":1,"day":"28","doi":"10.48550/ARXIV.2209.14368","ec_funded":1,"publication_status":"submitted","department":[{"_id":"GradSch"},{"_id":"KrCh"}],"corr_author":"1","date_published":"2022-09-28T00:00:00Z","month":"09","article_number":"2209.14368","acknowledgement":"This research was partially supported by the ERC CoG 863818 (ForM-SMArt) grant.","year":"2022","citation":{"ista":"Chatterjee K, Mohammadi M, Saona Urmeneta RJ. Repeated prophet inequality with near-optimal bounds. arXiv, 2209.14368.","chicago":"Chatterjee, Krishnendu, Mona Mohammadi, and Raimundo J Saona Urmeneta. “Repeated Prophet Inequality with Near-Optimal Bounds.” ArXiv, n.d. https://doi.org/10.48550/ARXIV.2209.14368.","short":"K. Chatterjee, M. Mohammadi, R.J. Saona Urmeneta, ArXiv (n.d.).","mla":"Chatterjee, Krishnendu, et al. “Repeated Prophet Inequality with Near-Optimal Bounds.” ArXiv, 2209.14368, doi:10.48550/ARXIV.2209.14368.","apa":"Chatterjee, K., Mohammadi, M., & Saona Urmeneta, R. J. (n.d.). Repeated prophet inequality with near-optimal bounds. arXiv. https://doi.org/10.48550/ARXIV.2209.14368","ama":"Chatterjee K, Mohammadi M, Saona Urmeneta RJ. Repeated prophet inequality with near-optimal bounds. arXiv. doi:10.48550/ARXIV.2209.14368","ieee":"K. Chatterjee, M. Mohammadi, and R. J. Saona Urmeneta, “Repeated prophet inequality with near-optimal bounds,” arXiv. ."},"status":"public","project":[{"_id":"0599E47C-7A3F-11EA-A408-12923DDC885E","call_identifier":"H2020","name":"Formal Methods for Stochastic Models: Algorithms and Applications","grant_number":"863818"}],"main_file_link":[{"url":" https://doi.org/10.48550/arXiv.2209.14368","open_access":"1"}]},{"date_created":"2023-03-23T14:33:13Z","publication":"arXiv","abstract":[{"text":"Quantum kinetically constrained models have recently attracted significant attention due to their anomalous dynamics and thermalization. In this work, we introduce a hitherto unexplored family of kinetically constrained models featuring a conserved particle number and strong inversion-symmetry breaking due to facilitated hopping. We demonstrate that these models provide a generic example of so-called quantum Hilbert space fragmentation, that is manifested in disconnected sectors in the Hilbert space that are not apparent in the computational basis. Quantum Hilbert space fragmentation leads to an exponential in system size number of eigenstates with exactly zero entanglement entropy across several bipartite cuts. These eigenstates can be probed dynamically using quenches from simple initial product states. In addition, we study the particle spreading under unitary dynamics launched from the domain wall state, and find faster than diffusive dynamics at high particle densities, that crosses over into logarithmically slow relaxation at smaller densities. Using a classically simulable cellular automaton, we reproduce the logarithmic dynamics observed in the quantum case. Our work suggests that particle conserving constrained models with inversion symmetry breaking realize so far unexplored universality classes of dynamics and invite their further theoretical and experimental studies.","lang":"eng"}],"date_updated":"2026-04-07T13:26:31Z","type":"preprint","_id":"12750","external_id":{"arxiv":["2210.15607"]},"title":"Hilbert space fragmentation and slow dynamics in particle-conserving quantum East models","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"repository","oa":1,"author":[{"first_name":"Pietro","orcid":"0000-0002-7969-2729","id":"4115AF5C-F248-11E8-B48F-1D18A9856A87","full_name":"Brighi, Pietro","last_name":"Brighi"},{"orcid":"0000-0003-0038-7068","first_name":"Marko","last_name":"Ljubotina","full_name":"Ljubotina, Marko","id":"F75EE9BE-5C90-11EA-905D-16643DDC885E"},{"full_name":"Serbyn, Maksym","id":"47809E7E-F248-11E8-B48F-1D18A9856A87","last_name":"Serbyn","orcid":"0000-0002-2399-5827","first_name":"Maksym"}],"citation":{"ama":"Brighi P, Ljubotina M, Serbyn M. Hilbert space fragmentation and slow dynamics in particle-conserving quantum East models. arXiv. doi:10.48550/arXiv.2210.15607","apa":"Brighi, P., Ljubotina, M., & Serbyn, M. (n.d.). Hilbert space fragmentation and slow dynamics in particle-conserving quantum East models. arXiv. https://doi.org/10.48550/arXiv.2210.15607","ieee":"P. Brighi, M. Ljubotina, and M. Serbyn, “Hilbert space fragmentation and slow dynamics in particle-conserving quantum East models,” arXiv. .","ista":"Brighi P, Ljubotina M, Serbyn M. Hilbert space fragmentation and slow dynamics in particle-conserving quantum East models. arXiv, 2210.15607.","short":"P. Brighi, M. Ljubotina, M. Serbyn, ArXiv (n.d.).","mla":"Brighi, Pietro, et al. “Hilbert Space Fragmentation and Slow Dynamics in Particle-Conserving Quantum East Models.” ArXiv, 2210.15607, doi:10.48550/arXiv.2210.15607.","chicago":"Brighi, Pietro, Marko Ljubotina, and Maksym Serbyn. “Hilbert Space Fragmentation and Slow Dynamics in Particle-Conserving Quantum East Models.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2210.15607."},"tmp":{"name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode"},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2210.15607"}],"status":"public","article_number":"2210.15607","year":"2022","doi":"10.48550/arXiv.2210.15607","day":"07","department":[{"_id":"GradSch"},{"_id":"MaSe"}],"publication_status":"draft","date_published":"2022-11-07T00:00:00Z","corr_author":"1","month":"11","related_material":{"record":[{"relation":"later_version","id":"14334","status":"public"},{"relation":"dissertation_contains","id":"12732","status":"public"}]},"language":[{"iso":"eng"}],"oa_version":"Preprint","arxiv":1,"article_processing_charge":"No"},{"citation":{"mla":"Bombari, Simone, et al. “Towards Differential Relational Privacy and Its Use in Question Answering.” ArXiv, 2203.16701, doi:10.48550/arXiv.2203.16701.","chicago":"Bombari, Simone, Alessandro Achille, Zijian Wang, Yu-Xiang Wang, Yusheng Xie, Kunwar Yashraj Singh, Srikar Appalaraju, Vijay Mahadevan, and Stefano Soatto. “Towards Differential Relational Privacy and Its Use in Question Answering.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2203.16701.","short":"S. Bombari, A. Achille, Z. Wang, Y.-X. Wang, Y. Xie, K.Y. Singh, S. Appalaraju, V. Mahadevan, S. Soatto, ArXiv (n.d.).","ista":"Bombari S, Achille A, Wang Z, Wang Y-X, Xie Y, Singh KY, Appalaraju S, Mahadevan V, Soatto S. Towards differential relational privacy and its use in question answering. arXiv, 2203.16701.","ieee":"S. Bombari et al., “Towards differential relational privacy and its use in question answering,” arXiv. .","apa":"Bombari, S., Achille, A., Wang, Z., Wang, Y.-X., Xie, Y., Singh, K. Y., … Soatto, S. (n.d.). Towards differential relational privacy and its use in question answering. arXiv. https://doi.org/10.48550/arXiv.2203.16701","ama":"Bombari S, Achille A, Wang Z, et al. Towards differential relational privacy and its use in question answering. arXiv. doi:10.48550/arXiv.2203.16701"},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2203.16701"}],"status":"public","article_number":"2203.16701","year":"2022","doi":"10.48550/arXiv.2203.16701","day":"30","department":[{"_id":"GradSch"},{"_id":"MaMo"}],"publication_status":"submitted","date_published":"2022-03-30T00:00:00Z","month":"03","oa_version":"Preprint","language":[{"iso":"eng"}],"arxiv":1,"article_processing_charge":"No","date_created":"2023-04-23T16:11:48Z","publication":"arXiv","abstract":[{"text":"Memorization of the relation between entities in a dataset can lead to privacy issues when using a trained model for question answering. We introduce Relational Memorization (RM) to understand, quantify and control this phenomenon. While bounding general memorization can have detrimental effects on the performance of a trained model, bounding RM does not prevent effective learning. The difference is most pronounced when the data distribution is long-tailed, with many queries having only few training examples: Impeding general memorization prevents effective learning, while impeding only relational memorization still allows learning general properties of the underlying concepts. We formalize the notion of Relational Privacy (RP) and, inspired by Differential Privacy (DP), we provide a possible definition of Differential Relational Privacy (DrP). These notions can be used to describe and compute bounds on the amount of RM in a trained model. We illustrate Relational Privacy concepts in experiments with large-scale models for Question Answering.","lang":"eng"}],"date_updated":"2023-04-25T07:34:49Z","type":"preprint","_id":"12860","external_id":{"arxiv":["2203.16701"]},"title":"Towards differential relational privacy and its use in question answering","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"author":[{"last_name":"Bombari","id":"ca726dda-de17-11ea-bc14-f9da834f63aa","full_name":"Bombari, Simone","first_name":"Simone"},{"last_name":"Achille","full_name":"Achille, Alessandro","first_name":"Alessandro"},{"last_name":"Wang","full_name":"Wang, Zijian","first_name":"Zijian"},{"first_name":"Yu-Xiang","last_name":"Wang","full_name":"Wang, Yu-Xiang"},{"first_name":"Yusheng","full_name":"Xie, Yusheng","last_name":"Xie"},{"first_name":"Kunwar Yashraj","last_name":"Singh","full_name":"Singh, Kunwar Yashraj"},{"last_name":"Appalaraju","full_name":"Appalaraju, Srikar","first_name":"Srikar"},{"first_name":"Vijay","full_name":"Mahadevan, Vijay","last_name":"Mahadevan"},{"first_name":"Stefano","full_name":"Soatto, Stefano","last_name":"Soatto"}]},{"ddc":["570"],"publisher":"Elsevier","year":"2022","date_published":"2022-10-01T00:00:00Z","page":"2194-2203","article_processing_charge":"No","intvolume":" 24","volume":24,"_id":"14355","issue":"10","extern":"1","author":[{"last_name":"Cali","full_name":"Cali, Elisa","first_name":"Elisa"},{"full_name":"Lin, Sheng-Jia","last_name":"Lin","first_name":"Sheng-Jia"},{"last_name":"Rocca","full_name":"Rocca, Clarissa","first_name":"Clarissa"},{"first_name":"Yavuz","full_name":"Sahin, Yavuz","last_name":"Sahin"},{"last_name":"Al Shamsi","full_name":"Al Shamsi, Aisha","first_name":"Aisha"},{"first_name":"Salima","last_name":"El Chehadeh","full_name":"El Chehadeh, Salima"},{"last_name":"Chaabouni","full_name":"Chaabouni, Myriam","first_name":"Myriam"},{"full_name":"Mankad, Kshitij","last_name":"Mankad","first_name":"Kshitij"},{"first_name":"Evangelia","last_name":"Galanaki","full_name":"Galanaki, Evangelia"},{"first_name":"Stephanie","full_name":"Efthymiou, Stephanie","last_name":"Efthymiou"},{"last_name":"Sudhakar","full_name":"Sudhakar, Sniya","first_name":"Sniya"},{"first_name":"Alkyoni","full_name":"Athanasiou-Fragkouli, Alkyoni","last_name":"Athanasiou-Fragkouli"},{"last_name":"Celik","full_name":"Celik, Tamer","first_name":"Tamer"},{"first_name":"Nejat","last_name":"Narli","full_name":"Narli, Nejat"},{"first_name":"Sebastiano","full_name":"Bianca, Sebastiano","last_name":"Bianca"},{"first_name":"David","last_name":"Murphy","full_name":"Murphy, David"},{"first_name":"Francisco Martins De Carvalho","last_name":"Moreira","full_name":"Moreira, Francisco Martins De Carvalho"},{"first_name":"Andrea","last_name":"Accogli","full_name":"Accogli, Andrea"},{"last_name":"Petree","full_name":"Petree, Cassidy","first_name":"Cassidy"},{"full_name":"Huang, Kevin","id":"3b3d2888-1ff6-11ee-9fa6-8f209ca91fe3","last_name":"Huang","orcid":"0000-0002-2512-7812","first_name":"Kevin"},{"first_name":"Kamel","last_name":"Monastiri","full_name":"Monastiri, Kamel"},{"first_name":"Masoud","last_name":"Edizadeh","full_name":"Edizadeh, Masoud"},{"first_name":"Rosaria","full_name":"Nardello, Rosaria","last_name":"Nardello"},{"last_name":"Ognibene","full_name":"Ognibene, Marzia","first_name":"Marzia"},{"last_name":"De Marco","full_name":"De Marco, Patrizia","first_name":"Patrizia"},{"full_name":"Ruggieri, Martino","last_name":"Ruggieri","first_name":"Martino"},{"last_name":"Zara","full_name":"Zara, Federico","first_name":"Federico"},{"first_name":"Pasquale","last_name":"Striano","full_name":"Striano, Pasquale"},{"first_name":"Yavuz","last_name":"Sahin","full_name":"Sahin, Yavuz"},{"last_name":"Al-Gazali","full_name":"Al-Gazali, Lihadh","first_name":"Lihadh"},{"full_name":"Warde, Marie Therese Abi","last_name":"Warde","first_name":"Marie Therese Abi"},{"full_name":"Gerard, Benedicte","last_name":"Gerard","first_name":"Benedicte"},{"full_name":"Zifarelli, Giovanni","last_name":"Zifarelli","first_name":"Giovanni"},{"full_name":"Beetz, Christian","last_name":"Beetz","first_name":"Christian"},{"first_name":"Sara","full_name":"Fortuna, Sara","last_name":"Fortuna"},{"full_name":"Soler, Miguel","last_name":"Soler","first_name":"Miguel"},{"first_name":"Enza Maria","full_name":"Valente, Enza Maria","last_name":"Valente"},{"first_name":"Gaurav","last_name":"Varshney","full_name":"Varshney, Gaurav"},{"first_name":"Reza","full_name":"Maroofian, Reza","last_name":"Maroofian"},{"last_name":"Salpietro","full_name":"Salpietro, Vincenzo","first_name":"Vincenzo"},{"full_name":"Houlden, Henry","last_name":"Houlden","first_name":"Henry"},{"full_name":"Grp, SYNaPS Study","last_name":"Grp","first_name":"SYNaPS Study"}],"file":[{"content_type":"application/pdf","relation":"main_file","checksum":"8117175a89129eb5022d81ffe7625f9f","success":1,"access_level":"open_access","date_updated":"2023-09-25T08:56:06Z","file_size":1434037,"creator":"dernst","date_created":"2023-09-25T08:56:06Z","file_id":"14371","file_name":"2022_GeneticsMedicine_Calin.pdf"}],"citation":{"ieee":"E. Cali et al., “A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease,” Genetics in Medicine, vol. 24, no. 10. Elsevier, pp. 2194–2203, 2022.","apa":"Cali, E., Lin, S.-J., Rocca, C., Sahin, Y., Al Shamsi, A., El Chehadeh, S., … Grp, Syn. S. (2022). A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease. Genetics in Medicine. Elsevier. https://doi.org/10.1016/j.gim.2022.07.013","ama":"Cali E, Lin S-J, Rocca C, et al. A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease. Genetics in Medicine. 2022;24(10):2194-2203. doi:10.1016/j.gim.2022.07.013","short":"E. Cali, S.-J. Lin, C. Rocca, Y. Sahin, A. Al Shamsi, S. El Chehadeh, M. Chaabouni, K. Mankad, E. Galanaki, S. Efthymiou, S. Sudhakar, A. Athanasiou-Fragkouli, T. Celik, N. Narli, S. Bianca, D. Murphy, F.M.D.C. Moreira, A. Accogli, C. Petree, K. Huang, K. Monastiri, M. Edizadeh, R. Nardello, M. Ognibene, P. De Marco, M. Ruggieri, F. Zara, P. Striano, Y. Sahin, L. Al-Gazali, M.T.A. Warde, B. Gerard, G. Zifarelli, C. Beetz, S. Fortuna, M. Soler, E.M. Valente, G. Varshney, R. Maroofian, V. Salpietro, H. Houlden, Syn.S. Grp, Genetics in Medicine 24 (2022) 2194–2203.","mla":"Cali, Elisa, et al. “A Homozygous MED11 C-Terminal Variant Causes a Lethal Neurodegenerative Disease.” Genetics in Medicine, vol. 24, no. 10, Elsevier, 2022, pp. 2194–203, doi:10.1016/j.gim.2022.07.013.","chicago":"Cali, Elisa, Sheng-Jia Lin, Clarissa Rocca, Yavuz Sahin, Aisha Al Shamsi, Salima El Chehadeh, Myriam Chaabouni, et al. “A Homozygous MED11 C-Terminal Variant Causes a Lethal Neurodegenerative Disease.” Genetics in Medicine. Elsevier, 2022. https://doi.org/10.1016/j.gim.2022.07.013.","ista":"Cali E, Lin S-J, Rocca C, Sahin Y, Al Shamsi A, El Chehadeh S, Chaabouni M, Mankad K, Galanaki E, Efthymiou S, Sudhakar S, Athanasiou-Fragkouli A, Celik T, Narli N, Bianca S, Murphy D, Moreira FMDC, Accogli A, Petree C, Huang K, Monastiri K, Edizadeh M, Nardello R, Ognibene M, De Marco P, Ruggieri M, Zara F, Striano P, Sahin Y, Al-Gazali L, Warde MTA, Gerard B, Zifarelli G, Beetz C, Fortuna S, Soler M, Valente EM, Varshney G, Maroofian R, Salpietro V, Houlden H, Grp SynS. 2022. A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease. Genetics in Medicine. 24(10), 2194–2203."},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"status":"public","scopus_import":"1","doi":"10.1016/j.gim.2022.07.013","day":"01","department":[{"_id":"GradSch"}],"publication_status":"published","month":"10","quality_controlled":"1","oa_version":"Published Version","language":[{"iso":"eng"}],"publication_identifier":{"issn":["1098-3600"]},"publication":"Genetics in Medicine","date_created":"2023-09-20T20:57:18Z","abstract":[{"lang":"eng","text":"Purpose: The mediator (MED) multisubunit-complex modulates the activity of the transcriptional machinery, and genetic defects in different MED subunits (17, 20, 27) have been implicated in neurologic diseases. In this study, we identified a recurrent homozygous variant in MED11 (c.325C>T; p.Arg109Ter) in 7 affected individuals from 5 unrelated families. Methods: To investigate the genetic cause of the disease, exome or genome sequencing were performed in 5 unrelated families identified via different research networks and Matchmaker Exchange. Deep clinical and brain imaging evaluations were performed by clinical pediatric neurologists and neuroradiologists. The functional effect of the candidate variant on both MED11 RNA and protein was assessed using reverse transcriptase polymerase chain reaction and western blotting using fibroblast cell lines derived from 1 affected individual and controls and through computational approaches. Knockouts in zebrafish were generated using clustered regularly interspaced short palindromic repeats/Cas9. Results: The disease was characterized by microcephaly, profound neurodevelopmental impairment, exaggerated startle response, myoclonic seizures, progressive widespread neurodegeneration, and premature death. Functional studies on patient-derived fibroblasts did not show a loss of protein function but rather disruption of the C-terminal of MED11, likely impairing binding to other MED subunits. A zebrafish knockout model recapitulates key clinical phenotypes. Conclusion: Loss of the C-terminal of MED subunit 11 may affect its binding efficiency to other MED subunits, thus implicating the MED-complex stability in brain development and neurodegeneration. (C) 2022 The Authors. Published by Elsevier Inc. on behalf of American College of Medical Genetics and Genomics."}],"date_updated":"2023-09-25T08:57:07Z","type":"journal_article","file_date_updated":"2023-09-25T08:56:06Z","title":"A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","oa":1,"has_accepted_license":"1","keyword":["Human mediator complex","MED11","MEDopathies"]},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Spectrum of equivariant cohomology as a fixed point scheme","_id":"17157","external_id":{"arxiv":["2212.11836"]},"OA_place":"repository","oa":1,"author":[{"first_name":"Tamás","orcid":"0000-0002-9582-2634","id":"4A0666D8-F248-11E8-B48F-1D18A9856A87","full_name":"Hausel, Tamás","last_name":"Hausel"},{"full_name":"Rychlewicz, Kamil P","id":"85A07246-A8BF-11E9-B4FA-D9E3E5697425","last_name":"Rychlewicz","first_name":"Kamil P"}],"date_created":"2024-06-23T15:01:27Z","publication":"arXiv","abstract":[{"text":"An action of a complex reductive group G on a smooth projective variety X is regular when all regular unipotent elements in G act with finitely many fixed points. Then the complex G-equivariant cohomology ring of X is isomorphic to the coordinate ring of a certain regular fixed point scheme. Examples include partial flag varieties, smooth Schubert varieties and Bott-Samelson varieties. We also show that a more general version of the fixed point scheme allows a generalisation to GKM spaces, such as toric varieties.","lang":"eng"}],"type":"preprint","date_updated":"2026-04-07T12:55:46Z","publication_status":"draft","department":[{"_id":"GradSch"},{"_id":"TaHa"}],"day":"22","doi":"10.48550/arXiv.2212.11836","related_material":{"record":[{"id":"19071","relation":"later_version","status":"public"},{"status":"public","id":"17156","relation":"dissertation_contains"}]},"date_published":"2022-12-22T00:00:00Z","month":"12","language":[{"iso":"eng"}],"oa_version":"Preprint","article_processing_charge":"No","arxiv":1,"citation":{"ista":"Hausel T, Rychlewicz KP. Spectrum of equivariant cohomology as a fixed point scheme. arXiv, 2212.11836.","short":"T. Hausel, K.P. Rychlewicz, ArXiv (n.d.).","mla":"Hausel, Tamás, and Kamil P. Rychlewicz. “Spectrum of Equivariant Cohomology as a Fixed Point Scheme.” ArXiv, 2212.11836, doi:10.48550/arXiv.2212.11836.","chicago":"Hausel, Tamás, and Kamil P Rychlewicz. “Spectrum of Equivariant Cohomology as a Fixed Point Scheme.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2212.11836.","apa":"Hausel, T., & Rychlewicz, K. P. (n.d.). Spectrum of equivariant cohomology as a fixed point scheme. arXiv. https://doi.org/10.48550/arXiv.2212.11836","ama":"Hausel T, Rychlewicz KP. Spectrum of equivariant cohomology as a fixed point scheme. arXiv. doi:10.48550/arXiv.2212.11836","ieee":"T. Hausel and K. P. Rychlewicz, “Spectrum of equivariant cohomology as a fixed point scheme,” arXiv. ."},"status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2212.11836"}],"year":"2022","article_number":"2212.11836"},{"volume":63,"intvolume":" 63","isi":1,"author":[{"first_name":"Sven Joscha","orcid":"0000-0003-1106-327X","id":"31d731d7-d235-11ea-ad11-b50331c8d7fb","full_name":"Henheik, Sven Joscha","last_name":"Henheik"},{"last_name":"Teufel","full_name":"Teufel, Stefan","first_name":"Stefan"}],"_id":"10600","external_id":{"isi":["000739446000009"],"arxiv":["2012.15238"]},"issue":"1","year":"2022","article_number":"011901","project":[{"_id":"62796744-2b32-11ec-9570-940b20777f1d","call_identifier":"H2020","name":"Random matrices beyond Wigner-Dyson-Mehta","grant_number":"101020331"}],"publisher":"AIP Publishing","article_processing_charge":"No","date_published":"2022-01-03T00:00:00Z","type":"journal_article","date_updated":"2025-04-14T07:57:17Z","publication":"Journal of Mathematical Physics","date_created":"2022-01-03T12:19:48Z","publication_identifier":{"issn":["0022-2488"],"eissn":["1089-7658"]},"abstract":[{"lang":"eng","text":"We show that recent results on adiabatic theory for interacting gapped many-body systems on finite lattices remain valid in the thermodynamic limit. More precisely, we prove a generalized super-adiabatic theorem for the automorphism group describing the infinite volume dynamics on the quasi-local algebra of observables. The key assumption is the existence of a sequence of gapped finite volume Hamiltonians, which generates the same infinite volume dynamics in the thermodynamic limit. Our adiabatic theorem also holds for certain perturbations of gapped ground states that close the spectral gap (so it is also an adiabatic theorem for resonances and, in this sense, “generalized”), and it provides an adiabatic approximation to all orders in the adiabatic parameter (a property often called “super-adiabatic”). In addition to the existing results for finite lattices, we also perform a resummation of the adiabatic expansion and allow for observables that are not strictly local. Finally, as an application, we prove the validity of linear and higher order response theory for our class of perturbations for infinite systems. While we consider the result and its proof as new and interesting in itself, we also lay the foundation for the proof of an adiabatic theorem for systems with a gap only in the bulk, which will be presented in a follow-up article."}],"oa":1,"keyword":["mathematical physics","statistical and nonlinear physics"],"title":"Adiabatic theorem in the thermodynamic limit: Systems with a uniform gap","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_type":"original","acknowledgement":"J.H. acknowledges partial financial support from ERC Advanced Grant “RMTBeyond” No. 101020331.","scopus_import":"1","citation":{"ista":"Henheik SJ, Teufel S. 2022. Adiabatic theorem in the thermodynamic limit: Systems with a uniform gap. Journal of Mathematical Physics. 63(1), 011901.","mla":"Henheik, Sven Joscha, and Stefan Teufel. “Adiabatic Theorem in the Thermodynamic Limit: Systems with a Uniform Gap.” Journal of Mathematical Physics, vol. 63, no. 1, 011901, AIP Publishing, 2022, doi:10.1063/5.0051632.","short":"S.J. Henheik, S. Teufel, Journal of Mathematical Physics 63 (2022).","chicago":"Henheik, Sven Joscha, and Stefan Teufel. “Adiabatic Theorem in the Thermodynamic Limit: Systems with a Uniform Gap.” Journal of Mathematical Physics. AIP Publishing, 2022. https://doi.org/10.1063/5.0051632.","ama":"Henheik SJ, Teufel S. Adiabatic theorem in the thermodynamic limit: Systems with a uniform gap. Journal of Mathematical Physics. 2022;63(1). doi:10.1063/5.0051632","apa":"Henheik, S. J., & Teufel, S. (2022). Adiabatic theorem in the thermodynamic limit: Systems with a uniform gap. Journal of Mathematical Physics. AIP Publishing. https://doi.org/10.1063/5.0051632","ieee":"S. J. Henheik and S. Teufel, “Adiabatic theorem in the thermodynamic limit: Systems with a uniform gap,” Journal of Mathematical Physics, vol. 63, no. 1. AIP Publishing, 2022."},"status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2012.15238"}],"oa_version":"Preprint","language":[{"iso":"eng"}],"quality_controlled":"1","arxiv":1,"department":[{"_id":"GradSch"},{"_id":"LaEr"}],"publication_status":"published","doi":"10.1063/5.0051632","ec_funded":1,"day":"03","month":"01"},{"article_type":"original","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","title":"The BCS critical temperature at high density","keyword":["geometry and topology","mathematical physics"],"oa":1,"has_accepted_license":"1","abstract":[{"lang":"eng","text":"We investigate the BCS critical temperature Tc in the high-density limit and derive an asymptotic formula, which strongly depends on the behavior of the interaction potential V on the Fermi-surface. Our results include a rigorous confirmation for the behavior of Tc at high densities proposed by Langmann et al. (Phys Rev Lett 122:157001, 2019) and identify precise conditions under which superconducting domes arise in BCS theory."}],"publication_identifier":{"issn":["1385-0172"],"eissn":["1572-9656"]},"publication":"Mathematical Physics, Analysis and Geometry","date_created":"2022-01-13T15:40:53Z","file_date_updated":"2022-01-14T07:27:45Z","date_updated":"2026-04-07T12:37:10Z","type":"journal_article","corr_author":"1","month":"01","related_material":{"record":[{"relation":"dissertation_contains","id":"19540","status":"public"}]},"day":"11","doi":"10.1007/s11040-021-09415-0","ec_funded":1,"publication_status":"published","department":[{"_id":"GradSch"},{"_id":"LaEr"}],"arxiv":1,"language":[{"iso":"eng"}],"oa_version":"Published Version","quality_controlled":"1","status":"public","file":[{"checksum":"d44f8123a52592a75b2c3b8ee2cd2435","relation":"main_file","content_type":"application/pdf","access_level":"open_access","success":1,"creator":"cchlebak","file_size":505804,"date_updated":"2022-01-14T07:27:45Z","file_name":"2022_MathPhyAnalGeo_Henheik.pdf","file_id":"10624","date_created":"2022-01-14T07:27:45Z"}],"citation":{"ista":"Henheik SJ. 2022. The BCS critical temperature at high density. Mathematical Physics, Analysis and Geometry. 25(1), 3.","chicago":"Henheik, Sven Joscha. “The BCS Critical Temperature at High Density.” Mathematical Physics, Analysis and Geometry. Springer Nature, 2022. https://doi.org/10.1007/s11040-021-09415-0.","mla":"Henheik, Sven Joscha. “The BCS Critical Temperature at High Density.” Mathematical Physics, Analysis and Geometry, vol. 25, no. 1, 3, Springer Nature, 2022, doi:10.1007/s11040-021-09415-0.","short":"S.J. Henheik, Mathematical Physics, Analysis and Geometry 25 (2022).","ama":"Henheik SJ. The BCS critical temperature at high density. Mathematical Physics, Analysis and Geometry. 2022;25(1). doi:10.1007/s11040-021-09415-0","apa":"Henheik, S. J. (2022). The BCS critical temperature at high density. Mathematical Physics, Analysis and Geometry. Springer Nature. https://doi.org/10.1007/s11040-021-09415-0","ieee":"S. J. Henheik, “The BCS critical temperature at high density,” Mathematical Physics, Analysis and Geometry, vol. 25, no. 1. Springer Nature, 2022."},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"scopus_import":"1","acknowledgement":"I am very grateful to Robert Seiringer for his guidance during this project and for many valuable comments on an earlier version of the manuscript. Moreover, I would like to thank Asbjørn Bækgaard Lauritsen for many helpful discussions and comments, pointing out the reference [22] and for his involvement in a closely related joint project [13]. Finally, I am grateful to Christian Hainzl for valuable comments on an earlier version of the manuscript and Andreas Deuchert for interesting discussions.","_id":"10623","issue":"1","external_id":{"arxiv":["2106.02015"],"isi":["000741387600001"]},"author":[{"last_name":"Henheik","id":"31d731d7-d235-11ea-ad11-b50331c8d7fb","full_name":"Henheik, Sven Joscha","first_name":"Sven Joscha","orcid":"0000-0003-1106-327X"}],"isi":1,"intvolume":" 25","volume":25,"date_published":"2022-01-11T00:00:00Z","article_processing_charge":"Yes (via OA deal)","publisher":"Springer Nature","project":[{"call_identifier":"H2020","name":"Random matrices beyond Wigner-Dyson-Mehta","grant_number":"101020331","_id":"62796744-2b32-11ec-9570-940b20777f1d"},{"name":"IST Austria Open Access Fund","_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854"}],"ddc":["514"],"article_number":"3","year":"2022"},{"abstract":[{"text":"Based on a result by Yarotsky (J Stat Phys 118, 2005), we prove that localized but otherwise arbitrary perturbations of weakly interacting quantum spin systems with uniformly gapped on-site terms change the ground state of such a system only locally, even if they close the spectral gap. We call this a strong version of the local perturbations perturb locally (LPPL) principle which is known to hold for much more general gapped systems, but only for perturbations that do not close the spectral gap of the Hamiltonian. We also extend this strong LPPL-principle to Hamiltonians that have the appropriate structure of gapped on-site terms and weak interactions only locally in some region of space. While our results are technically corollaries to a theorem of Yarotsky, we expect that the paradigm of systems with a locally gapped ground state that is completely insensitive to the form of the Hamiltonian elsewhere extends to other situations and has important physical consequences.","lang":"eng"}],"publication_identifier":{"issn":["0377-9017"],"eissn":["1573-0530"]},"publication":"Letters in Mathematical Physics","date_created":"2022-01-18T16:18:25Z","file_date_updated":"2022-01-19T09:41:14Z","date_updated":"2026-04-07T12:37:10Z","type":"journal_article","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Local stability of ground states in locally gapped and weakly interacting quantum spin systems","keyword":["mathematical physics","statistical and nonlinear physics"],"has_accepted_license":"1","oa":1,"status":"public","file":[{"date_created":"2022-01-19T09:41:14Z","file_id":"10647","file_name":"2022_LettersMathPhys_Henheik.pdf","date_updated":"2022-01-19T09:41:14Z","creator":"cchlebak","file_size":357547,"access_level":"open_access","success":1,"content_type":"application/pdf","checksum":"7e8e69b76e892c305071a4736131fe18","relation":"main_file"}],"citation":{"apa":"Henheik, S. J., Teufel, S., & Wessel, T. (2022). Local stability of ground states in locally gapped and weakly interacting quantum spin systems. Letters in Mathematical Physics. Springer Nature. https://doi.org/10.1007/s11005-021-01494-y","ama":"Henheik SJ, Teufel S, Wessel T. Local stability of ground states in locally gapped and weakly interacting quantum spin systems. Letters in Mathematical Physics. 2022;112(1). doi:10.1007/s11005-021-01494-y","ieee":"S. J. Henheik, S. Teufel, and T. Wessel, “Local stability of ground states in locally gapped and weakly interacting quantum spin systems,” Letters in Mathematical Physics, vol. 112, no. 1. Springer Nature, 2022.","ista":"Henheik SJ, Teufel S, Wessel T. 2022. Local stability of ground states in locally gapped and weakly interacting quantum spin systems. Letters in Mathematical Physics. 112(1), 9.","chicago":"Henheik, Sven Joscha, Stefan Teufel, and Tom Wessel. “Local Stability of Ground States in Locally Gapped and Weakly Interacting Quantum Spin Systems.” Letters in Mathematical Physics. Springer Nature, 2022. https://doi.org/10.1007/s11005-021-01494-y.","mla":"Henheik, Sven Joscha, et al. “Local Stability of Ground States in Locally Gapped and Weakly Interacting Quantum Spin Systems.” Letters in Mathematical Physics, vol. 112, no. 1, 9, Springer Nature, 2022, doi:10.1007/s11005-021-01494-y.","short":"S.J. Henheik, S. Teufel, T. Wessel, Letters in Mathematical Physics 112 (2022)."},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"scopus_import":"1","acknowledgement":"J. H. acknowledges partial financial support by the ERC Advanced Grant “RMTBeyond” No. 101020331. S. T. thanks Marius Lemm and Simone Warzel for very helpful comments and discussions and Jürg Fröhlich for references to the literature. Open Access funding enabled and organized by Projekt DEAL.","month":"01","related_material":{"record":[{"relation":"dissertation_contains","id":"19540","status":"public"}]},"doi":"10.1007/s11005-021-01494-y","ec_funded":1,"day":"18","department":[{"_id":"GradSch"},{"_id":"LaEr"}],"publication_status":"published","arxiv":1,"oa_version":"Published Version","language":[{"iso":"eng"}],"quality_controlled":"1","intvolume":" 112","volume":112,"_id":"10642","external_id":{"pmid":["35125630"],"arxiv":["2106.13780"],"isi":["000744930400001"]},"issue":"1","author":[{"last_name":"Henheik","full_name":"Henheik, Sven Joscha","id":"31d731d7-d235-11ea-ad11-b50331c8d7fb","orcid":"0000-0003-1106-327X","first_name":"Sven Joscha"},{"first_name":"Stefan","full_name":"Teufel, Stefan","last_name":"Teufel"},{"full_name":"Wessel, Tom","last_name":"Wessel","first_name":"Tom"}],"isi":1,"publisher":"Springer Nature","project":[{"grant_number":"101020331","name":"Random matrices beyond Wigner-Dyson-Mehta","call_identifier":"H2020","_id":"62796744-2b32-11ec-9570-940b20777f1d"}],"ddc":["530"],"article_number":"9","year":"2022","pmid":1,"date_published":"2022-01-18T00:00:00Z","article_processing_charge":"No"},{"intvolume":" 10","volume":10,"_id":"10643","external_id":{"arxiv":["2012.15239"],"isi":["000743615000001"]},"isi":1,"author":[{"orcid":"0000-0003-1106-327X","first_name":"Sven Joscha","full_name":"Henheik, Sven Joscha","id":"31d731d7-d235-11ea-ad11-b50331c8d7fb","last_name":"Henheik"},{"last_name":"Teufel","full_name":"Teufel, Stefan","first_name":"Stefan"}],"ddc":["510"],"project":[{"_id":"62796744-2b32-11ec-9570-940b20777f1d","grant_number":"101020331","call_identifier":"H2020","name":"Random matrices beyond Wigner-Dyson-Mehta"}],"publisher":"Cambridge University Press","year":"2022","article_number":"e4","date_published":"2022-01-18T00:00:00Z","article_processing_charge":"Yes","date_created":"2022-01-18T16:18:51Z","publication":"Forum of Mathematics, Sigma","publication_identifier":{"eissn":["2050-5094"]},"abstract":[{"lang":"eng","text":"We prove a generalised super-adiabatic theorem for extended fermionic systems assuming a spectral gap only in the bulk. More precisely, we assume that the infinite system has a unique ground state and that the corresponding Gelfand–Naimark–Segal Hamiltonian has a spectral gap above its eigenvalue zero. Moreover, we show that a similar adiabatic theorem also holds in the bulk of finite systems up to errors that vanish faster than any inverse power of the system size, although the corresponding finite-volume Hamiltonians need not have a spectral gap.\r\n\r\n"}],"type":"journal_article","date_updated":"2025-04-14T07:57:17Z","file_date_updated":"2022-01-19T09:27:43Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","title":"Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk","article_type":"original","has_accepted_license":"1","oa":1,"keyword":["computational mathematics","discrete mathematics and combinatorics","geometry and topology","mathematical physics","statistics and probability","algebra and number theory","theoretical computer science","analysis"],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"citation":{"short":"S.J. Henheik, S. Teufel, Forum of Mathematics, Sigma 10 (2022).","chicago":"Henheik, Sven Joscha, and Stefan Teufel. “Adiabatic Theorem in the Thermodynamic Limit: Systems with a Gap in the Bulk.” Forum of Mathematics, Sigma. Cambridge University Press, 2022. https://doi.org/10.1017/fms.2021.80.","mla":"Henheik, Sven Joscha, and Stefan Teufel. “Adiabatic Theorem in the Thermodynamic Limit: Systems with a Gap in the Bulk.” Forum of Mathematics, Sigma, vol. 10, e4, Cambridge University Press, 2022, doi:10.1017/fms.2021.80.","ista":"Henheik SJ, Teufel S. 2022. Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk. Forum of Mathematics, Sigma. 10, e4.","ieee":"S. J. Henheik and S. Teufel, “Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk,” Forum of Mathematics, Sigma, vol. 10. Cambridge University Press, 2022.","apa":"Henheik, S. J., & Teufel, S. (2022). Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk. Forum of Mathematics, Sigma. Cambridge University Press. https://doi.org/10.1017/fms.2021.80","ama":"Henheik SJ, Teufel S. Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk. Forum of Mathematics, Sigma. 2022;10. doi:10.1017/fms.2021.80"},"file":[{"success":1,"access_level":"open_access","content_type":"application/pdf","relation":"main_file","checksum":"87592a755adcef22ea590a99dc728dd3","file_id":"10646","date_created":"2022-01-19T09:27:43Z","file_name":"2022_ForumMathSigma_Henheik.pdf","date_updated":"2022-01-19T09:27:43Z","file_size":705323,"creator":"cchlebak"}],"status":"public","scopus_import":"1","acknowledgement":"J.H. acknowledges partial financial support by the ERC Advanced Grant ‘RMTBeyond’ No. 101020331. Support for publication costs from the Deutsche Forschungsgemeinschaft and the Open Access Publishing Fund of the University of Tübingen is gratefully acknowledged.","department":[{"_id":"GradSch"},{"_id":"LaEr"}],"publication_status":"published","ec_funded":1,"day":"18","doi":"10.1017/fms.2021.80","corr_author":"1","month":"01","quality_controlled":"1","oa_version":"Published Version","language":[{"iso":"eng"}],"arxiv":1},{"scopus_import":"1","acknowledgement":"This research was partly funded by the Austrian Science Fund (FWF) (grant no. P-32896B).","status":"public","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"file":[{"access_level":"open_access","content_type":"application/pdf","checksum":"04ca9e2f0e344d680b947f2457df8d0a","relation":"main_file","date_created":"2022-01-24T10:34:45Z","file_id":"10659","file_name":"rstb.2021.0010.pdf","date_updated":"2022-01-24T10:34:45Z","creator":"oolusany","file_size":1845792}],"citation":{"ista":"Sachdeva H, Olusanya OO, Barton NH. 2022. Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity. Philosophical Transactions of the Royal Society B. 377(1846), 20210010.","chicago":"Sachdeva, Himani, Oluwafunmilola O Olusanya, and Nicholas H Barton. “Genetic Load and Extinction in Peripheral Populations: The Roles of Migration, Drift and Demographic Stochasticity.” Philosophical Transactions of the Royal Society B. The Royal Society, 2022. https://doi.org/10.1098/rstb.2021.0010.","mla":"Sachdeva, Himani, et al. “Genetic Load and Extinction in Peripheral Populations: The Roles of Migration, Drift and Demographic Stochasticity.” Philosophical Transactions of the Royal Society B, vol. 377, no. 1846, 20210010, The Royal Society, 2022, doi:10.1098/rstb.2021.0010.","short":"H. Sachdeva, O.O. Olusanya, N.H. Barton, Philosophical Transactions of the Royal Society B 377 (2022).","ama":"Sachdeva H, Olusanya OO, Barton NH. Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity. Philosophical Transactions of the Royal Society B. 2022;377(1846). doi:10.1098/rstb.2021.0010","apa":"Sachdeva, H., Olusanya, O. O., & Barton, N. H. (2022). Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity. Philosophical Transactions of the Royal Society B. The Royal Society. https://doi.org/10.1098/rstb.2021.0010","ieee":"H. Sachdeva, O. O. Olusanya, and N. H. Barton, “Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity,” Philosophical Transactions of the Royal Society B, vol. 377, no. 1846. The Royal Society, 2022."},"quality_controlled":"1","language":[{"iso":"eng"}],"oa_version":"Published Version","related_material":{"record":[{"status":"public","id":"14711","relation":"dissertation_contains"}],"link":[{"url":"https://doi.org/10.1101/2021.08.05.455207","relation":"earlier_version"}]},"month":"01","department":[{"_id":"GradSch"},{"_id":"NiBa"}],"publication_status":"published","doi":"10.1098/rstb.2021.0010","day":"24","file_date_updated":"2022-01-24T10:34:45Z","type":"journal_article","date_updated":"2026-04-07T12:54:28Z","abstract":[{"text":"We analyse how migration from a large mainland influences genetic load and population numbers on an island, in a scenario where fitness-affecting variants are unconditionally deleterious, and where numbers decline with increasing load. Our analysis shows that migration can have qualitatively different effects, depending on the total mutation target and fitness effects of deleterious variants. In particular, we find that populations exhibit a genetic Allee effect across a wide range of parameter combinations, when variants are partially recessive, cycling between low-load (large-population) and high-load (sink) states. Increased migration reduces load in the sink state (by increasing heterozygosity) but further inflates load in the large-population state (by hindering purging). We identify various critical parameter thresholds at which one or other stable state collapses, and discuss how these thresholds are influenced by the genetic versus demographic effects of migration. Our analysis is based on a ‘semi-deterministic’ analysis, which accounts for genetic drift but neglects demographic stochasticity. We also compare against simulations which account for both demographic stochasticity and drift. Our results clarify the importance of gene flow as a key determinant of extinction risk in peripheral populations, even in the absence of ecological gradients. This article is part of the theme issue ‘Species’ ranges in the face of changing environments (part I)’.","lang":"eng"}],"publication":"Philosophical Transactions of the Royal Society B","date_created":"2022-01-24T10:34:53Z","publication_identifier":{"eissn":["1471-2970"],"issn":["0962-8436"]},"has_accepted_license":"1","oa":1,"article_type":"original","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","title":"Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity","year":"2022","article_number":"20210010","project":[{"_id":"c08d3278-5a5b-11eb-8a69-fdb09b55f4b8","grant_number":"P32896","name":"Causes and consequences of population fragmentation"}],"publisher":"The Royal Society","ddc":["576"],"article_processing_charge":"No","date_published":"2022-01-24T00:00:00Z","pmid":1,"volume":377,"intvolume":" 377","author":[{"full_name":"Sachdeva, Himani","last_name":"Sachdeva","first_name":"Himani"},{"id":"41AD96DC-F248-11E8-B48F-1D18A9856A87","full_name":"Olusanya, Oluwafunmilola O","last_name":"Olusanya","first_name":"Oluwafunmilola O","orcid":"0000-0003-1971-8314"},{"first_name":"Nicholas H","orcid":"0000-0002-8548-5240","last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H"}],"isi":1,"_id":"10658","external_id":{"isi":["000745854300008"],"pmid":["35067097"]},"issue":"1846"},{"alternative_title":["ISTA Thesis"],"_id":"10759","author":[{"full_name":"Rzadkowski, Wojciech","id":"48C55298-F248-11E8-B48F-1D18A9856A87","last_name":"Rzadkowski","orcid":"0000-0002-1106-4419","first_name":"Wojciech"}],"date_published":"2022-02-21T00:00:00Z","article_processing_charge":"No","page":"120","project":[{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","call_identifier":"H2020","grant_number":"665385"}],"publisher":"Institute of Science and Technology Austria","ddc":["530"],"year":"2022","degree_awarded":"PhD","OA_place":"publisher","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","title":"Analytic and machine learning approaches to composite quantum impurities","oa":1,"has_accepted_license":"1","abstract":[{"text":"In this Thesis, I study composite quantum impurities with variational techniques, both inspired by machine learning as well as fully analytic. I supplement this with exploration of other applications of machine learning, in particular artificial neural networks, in many-body physics. In Chapters 3 and 4, I study quasiparticle systems with variational approach. I derive a Hamiltonian describing the angulon quasiparticle in the presence of a magnetic field. I apply analytic variational treatment to this Hamiltonian. Then, I introduce a variational approach for non-additive systems, based on artificial neural networks. I exemplify this approach on the example of the polaron quasiparticle (Fröhlich Hamiltonian). In Chapter 5, I continue using artificial neural networks, albeit in a different setting. I apply artificial neural networks to detect phases from snapshots of two types physical systems. Namely, I study Monte Carlo snapshots of multilayer classical spin models as well as molecular dynamics maps of colloidal systems. The main type of networks that I use here are convolutional neural networks, known for their applicability to image data.","lang":"eng"}],"date_created":"2022-02-16T13:27:37Z","supervisor":[{"last_name":"Lemeshko","full_name":"Lemeshko, Mikhail","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6990-7802","first_name":"Mikhail"}],"publication_identifier":{"issn":["2663-337X"]},"file_date_updated":"2022-02-22T07:20:12Z","type":"dissertation","date_updated":"2026-06-18T19:29:09Z","related_material":{"record":[{"status":"public","id":"10762","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"415","status":"public"},{"id":"8644","relation":"part_of_dissertation","status":"public"},{"status":"public","id":"7956","relation":"part_of_dissertation"}]},"month":"02","corr_author":"1","department":[{"_id":"GradSch"},{"_id":"MiLe"}],"publication_status":"published","day":"21","doi":"10.15479/at:ista:10759","ec_funded":1,"oa_version":"Published Version","language":[{"iso":"eng"}],"status":"public","file":[{"file_id":"10785","date_created":"2022-02-21T13:58:16Z","file_name":"Rzadkowski_thesis_final_source.zip","date_updated":"2022-02-22T07:20:12Z","file_size":17668233,"creator":"wrzadkow","access_level":"closed","content_type":"application/zip","relation":"source_file","checksum":"0fc54ad1eaede879c665ac9b53c93e22"},{"date_updated":"2022-02-21T14:02:54Z","creator":"wrzadkow","file_size":13307331,"file_id":"10786","date_created":"2022-02-21T14:02:54Z","file_name":"Rzadkowski_thesis_final.pdf","content_type":"application/pdf","checksum":"22d2d7af37ca31f6b1730c26cac7bced","relation":"main_file","access_level":"open_access","success":1}],"citation":{"mla":"Rzadkowski, Wojciech. Analytic and Machine Learning Approaches to Composite Quantum Impurities. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:10759.","short":"W. Rzadkowski, Analytic and Machine Learning Approaches to Composite Quantum Impurities, Institute of Science and Technology Austria, 2022.","chicago":"Rzadkowski, Wojciech. “Analytic and Machine Learning Approaches to Composite Quantum Impurities.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:10759.","ista":"Rzadkowski W. 2022. Analytic and machine learning approaches to composite quantum impurities. Institute of Science and Technology Austria.","ieee":"W. Rzadkowski, “Analytic and machine learning approaches to composite quantum impurities,” Institute of Science and Technology Austria, 2022.","ama":"Rzadkowski W. Analytic and machine learning approaches to composite quantum impurities. 2022. doi:10.15479/at:ista:10759","apa":"Rzadkowski, W. (2022). Analytic and machine learning approaches to composite quantum impurities. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:10759"}},{"year":"2022","ddc":["570"],"project":[{"grant_number":"P32896","name":"Causes and consequences of population fragmentation","_id":"c08d3278-5a5b-11eb-8a69-fdb09b55f4b8"}],"publisher":"The Royal Society","article_processing_charge":"No","pmid":1,"date_published":"2022-04-11T00:00:00Z","volume":377,"intvolume":" 377","author":[{"orcid":"0000-0002-8548-5240","first_name":"Nicholas H","last_name":"Barton","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0003-1971-8314","first_name":"Oluwafunmilola O","full_name":"Olusanya, Oluwafunmilola O","id":"41AD96DC-F248-11E8-B48F-1D18A9856A87","last_name":"Olusanya"}],"isi":1,"_id":"10787","external_id":{"isi":["000758140300001"],"pmid":["35184588"]},"issue":"1848","scopus_import":"1","acknowledgement":"This research was partly funded by the Austrian Science Fund (FWF) [FWF P-32896B].","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"file":[{"success":1,"access_level":"open_access","content_type":"application/pdf","relation":"main_file","checksum":"3b0243738f01bf3c07e0d7e8dc64f71d","date_created":"2022-08-02T06:14:32Z","file_id":"11719","file_name":"2022_PhilosophicalTransactionsRSB_Barton.pdf","date_updated":"2022-08-02T06:14:32Z","file_size":1349672,"creator":"dernst"}],"citation":{"apa":"Barton, N. H., & Olusanya, O. O. (2022). The response of a metapopulation to a changing environment. Philosophical Transactions of the Royal Society B: Biological Sciences. The Royal Society. https://doi.org/10.1098/rstb.2021.0009","ama":"Barton NH, Olusanya OO. The response of a metapopulation to a changing environment. Philosophical Transactions of the Royal Society B: Biological Sciences. 2022;377(1848). doi:10.1098/rstb.2021.0009","ieee":"N. H. Barton and O. O. Olusanya, “The response of a metapopulation to a changing environment,” Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 377, no. 1848. The Royal Society, 2022.","ista":"Barton NH, Olusanya OO. 2022. The response of a metapopulation to a changing environment. Philosophical Transactions of the Royal Society B: Biological Sciences. 377(1848).","mla":"Barton, Nicholas H., and Oluwafunmilola O. Olusanya. “The Response of a Metapopulation to a Changing Environment.” Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 377, no. 1848, The Royal Society, 2022, doi:10.1098/rstb.2021.0009.","short":"N.H. Barton, O.O. Olusanya, Philosophical Transactions of the Royal Society B: Biological Sciences 377 (2022).","chicago":"Barton, Nicholas H, and Oluwafunmilola O Olusanya. “The Response of a Metapopulation to a Changing Environment.” Philosophical Transactions of the Royal Society B: Biological Sciences. The Royal Society, 2022. https://doi.org/10.1098/rstb.2021.0009."},"status":"public","language":[{"iso":"eng"}],"oa_version":"Published Version","quality_controlled":"1","publication_status":"published","department":[{"_id":"GradSch"},{"_id":"NiBa"}],"day":"11","doi":"10.1098/rstb.2021.0009","related_material":{"record":[{"status":"public","id":"14711","relation":"dissertation_contains"}]},"month":"04","corr_author":"1","type":"journal_article","date_updated":"2026-04-07T12:54:28Z","file_date_updated":"2022-08-02T06:14:32Z","publication":"Philosophical Transactions of the Royal Society B: Biological Sciences","date_created":"2022-02-21T16:08:10Z","publication_identifier":{"eissn":["1471-2970"],"issn":["0962-8436"]},"abstract":[{"text":"A species distributed across diverse environments may adapt to local conditions. We ask how quickly such a species changes its range in response to changed conditions. Szép et al. (Szép E, Sachdeva H, Barton NH. 2021 Polygenic local adaptation in metapopulations: a stochastic eco-evolutionary model. Evolution75, 1030–1045 (doi:10.1111/evo.14210)) used the infinite island model to find the stationary distribution of allele frequencies and deme sizes. We extend this to find how a metapopulation responds to changes in carrying capacity, selection strength, or migration rate when deme sizes are fixed. We further develop a ‘fixed-state’ approximation. Under this approximation, polymorphism is only possible for a narrow range of habitat proportions when selection is weak compared to drift, but for a much wider range otherwise. When rates of selection or migration relative to drift change in a single deme of the metapopulation, the population takes a time of order m−1 to reach the new equilibrium. However, even with many loci, there can be substantial fluctuations in net adaptation, because at each locus, alleles randomly get lost or fixed. Thus, in a finite metapopulation, variation may gradually be lost by chance, even if it would persist in an infinite metapopulation. When conditions change across the whole metapopulation, there can be rapid change, which is predicted well by the fixed-state approximation. This work helps towards an understanding of how metapopulations extend their range across diverse environments.\r\nThis article is part of the theme issue ‘Species’ ranges in the face of changing environments (Part II)’.","lang":"eng"}],"oa":1,"has_accepted_license":"1","keyword":["General Agricultural and Biological Sciences","General Biochemistry","Genetics and Molecular Biology"],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","title":"The response of a metapopulation to a changing environment","article_type":"original"},{"OA_place":"publisher","title":"Robustness and fairness in machine learning","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","keyword":["robustness","fairness","machine learning","PAC learning","adversarial learning"],"oa":1,"has_accepted_license":"1","abstract":[{"lang":"eng","text":"Because of the increasing popularity of machine learning methods, it is becoming important to understand the impact of learned components on automated decision-making systems and to guarantee that their consequences are beneficial to society. In other words, it is necessary to ensure that machine learning is sufficiently trustworthy to be used in real-world applications. This thesis studies two properties of machine learning models that are highly desirable for the\r\nsake of reliability: robustness and fairness. In the first part of the thesis we study the robustness of learning algorithms to training data corruption. Previous work has shown that machine learning models are vulnerable to a range\r\nof training set issues, varying from label noise through systematic biases to worst-case data manipulations. This is an especially relevant problem from a present perspective, since modern machine learning methods are particularly data hungry and therefore practitioners often have to rely on data collected from various external sources, e.g. from the Internet, from app users or via crowdsourcing. Naturally, such sources vary greatly in the quality and reliability of the\r\ndata they provide. With these considerations in mind, we study the problem of designing machine learning algorithms that are robust to corruptions in data coming from multiple sources. We show that, in contrast to the case of a single dataset with outliers, successful learning within this model is possible both theoretically and practically, even under worst-case data corruptions. The second part of this thesis deals with fairness-aware machine learning. There are multiple areas where machine learning models have shown promising results, but where careful considerations are required, in order to avoid discrimanative decisions taken by such learned components. Ensuring fairness can be particularly challenging, because real-world training datasets are expected to contain various forms of historical bias that may affect the learning process. In this thesis we show that data corruption can indeed render the problem of achieving fairness impossible, by tightly characterizing the theoretical limits of fair learning under worst-case data manipulations. However, assuming access to clean data, we also show how fairness-aware learning can be made practical in contexts beyond binary classification, in particular in the challenging learning to rank setting."}],"publication_identifier":{"isbn":["978-3-99078-015-2"],"issn":["2663-337X"]},"date_created":"2022-02-28T13:03:49Z","supervisor":[{"orcid":"0000-0001-8622-7887","first_name":"Christoph","last_name":"Lampert","full_name":"Lampert, Christoph","id":"40C20FD2-F248-11E8-B48F-1D18A9856A87"}],"file_date_updated":"2022-03-10T12:11:48Z","date_updated":"2026-04-07T14:19:48Z","type":"dissertation","corr_author":"1","month":"03","related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"10802"},{"status":"public","id":"10803","relation":"part_of_dissertation"},{"status":"public","id":"6590","relation":"part_of_dissertation"},{"id":"8724","relation":"part_of_dissertation","status":"public"}]},"ec_funded":1,"day":"08","doi":"10.15479/at:ista:10799","department":[{"_id":"GradSch"},{"_id":"ChLa"}],"publication_status":"published","language":[{"iso":"eng"}],"oa_version":"Published Version","status":"public","file":[{"date_updated":"2022-03-06T11:42:54Z","file_size":4204905,"creator":"nkonstan","date_created":"2022-03-06T11:42:54Z","file_id":"10823","file_name":"thesis.pdf","content_type":"application/pdf","relation":"main_file","checksum":"626bc523ae8822d20e635d0e2d95182e","success":1,"access_level":"open_access"},{"checksum":"e2ca2b88350ac8ea1515b948885cbcb1","relation":"source_file","content_type":"application/x-zip-compressed","access_level":"closed","creator":"nkonstan","file_size":22841103,"date_updated":"2022-03-10T12:11:48Z","file_name":"thesis.zip","file_id":"10824","date_created":"2022-03-06T11:42:57Z"}],"citation":{"short":"N.H. Konstantinov, Robustness and Fairness in Machine Learning, Institute of Science and Technology Austria, 2022.","chicago":"Konstantinov, Nikola H. “Robustness and Fairness in Machine Learning.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:10799.","mla":"Konstantinov, Nikola H. Robustness and Fairness in Machine Learning. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:10799.","ista":"Konstantinov NH. 2022. Robustness and fairness in machine learning. Institute of Science and Technology Austria.","ieee":"N. H. Konstantinov, “Robustness and fairness in machine learning,” Institute of Science and Technology Austria, 2022.","ama":"Konstantinov NH. Robustness and fairness in machine learning. 2022. doi:10.15479/at:ista:10799","apa":"Konstantinov, N. H. (2022). Robustness and fairness in machine learning. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:10799"},"_id":"10799","alternative_title":["ISTA Thesis"],"author":[{"orcid":"0009-0009-5204-7621","first_name":"Nikola H","last_name":"Konstantinov","full_name":"Konstantinov, Nikola H","id":"4B9D76E4-F248-11E8-B48F-1D18A9856A87"}],"date_published":"2022-03-08T00:00:00Z","article_processing_charge":"No","page":"176","publisher":"Institute of Science and Technology Austria","project":[{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"International IST Doctoral Program","grant_number":"665385"}],"ddc":["000"],"degree_awarded":"PhD","year":"2022"},{"project":[{"_id":"25863FF4-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Game Theory","grant_number":"S11407"}],"publisher":"Institute for Operations Research and the Management Sciences","year":"2022","date_published":"2022-02-01T00:00:00Z","page":"100-119","article_processing_charge":"No","intvolume":" 47","volume":47,"issue":"1","_id":"9311","external_id":{"arxiv":["1904.13360"],"isi":["000731918100001"]},"author":[{"orcid":"0000-0002-4561-241X","first_name":"Krishnendu","last_name":"Chatterjee","full_name":"Chatterjee, Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"},{"id":"BD1DF4C4-D767-11E9-B658-BC13E6697425","full_name":"Saona Urmeneta, Raimundo J","last_name":"Saona Urmeneta","first_name":"Raimundo J","orcid":"0000-0001-5103-038X"},{"first_name":"Bruno","last_name":"Ziliotto","full_name":"Ziliotto, Bruno"}],"isi":1,"citation":{"ama":"Chatterjee K, Saona Urmeneta RJ, Ziliotto B. Finite-memory strategies in POMDPs with long-run average objectives. Mathematics of Operations Research. 2022;47(1):100-119. doi:10.1287/moor.2020.1116","apa":"Chatterjee, K., Saona Urmeneta, R. J., & Ziliotto, B. (2022). Finite-memory strategies in POMDPs with long-run average objectives. Mathematics of Operations Research. Institute for Operations Research and the Management Sciences. https://doi.org/10.1287/moor.2020.1116","ieee":"K. Chatterjee, R. J. Saona Urmeneta, and B. Ziliotto, “Finite-memory strategies in POMDPs with long-run average objectives,” Mathematics of Operations Research, vol. 47, no. 1. Institute for Operations Research and the Management Sciences, pp. 100–119, 2022.","ista":"Chatterjee K, Saona Urmeneta RJ, Ziliotto B. 2022. Finite-memory strategies in POMDPs with long-run average objectives. Mathematics of Operations Research. 47(1), 100–119.","mla":"Chatterjee, Krishnendu, et al. “Finite-Memory Strategies in POMDPs with Long-Run Average Objectives.” Mathematics of Operations Research, vol. 47, no. 1, Institute for Operations Research and the Management Sciences, 2022, pp. 100–19, doi:10.1287/moor.2020.1116.","chicago":"Chatterjee, Krishnendu, Raimundo J Saona Urmeneta, and Bruno Ziliotto. “Finite-Memory Strategies in POMDPs with Long-Run Average Objectives.” Mathematics of Operations Research. Institute for Operations Research and the Management Sciences, 2022. https://doi.org/10.1287/moor.2020.1116.","short":"K. Chatterjee, R.J. Saona Urmeneta, B. Ziliotto, Mathematics of Operations Research 47 (2022) 100–119."},"main_file_link":[{"url":"https://arxiv.org/abs/1904.13360","open_access":"1"}],"status":"public","scopus_import":"1","acknowledgement":"Partially supported by Austrian Science Fund (FWF) NFN Grant No RiSE/SHiNE S11407, by CONICYT Chile through grant PII 20150140, and by ECOS-CONICYT through grant C15E03.\r\n","publication_status":"published","department":[{"_id":"GradSch"},{"_id":"KrCh"}],"day":"01","doi":"10.1287/moor.2020.1116","related_material":{"record":[{"status":"public","id":"20234","relation":"dissertation_contains"}]},"month":"02","quality_controlled":"1","oa_version":"Preprint","language":[{"iso":"eng"}],"arxiv":1,"publication":"Mathematics of Operations Research","date_created":"2021-04-08T09:33:31Z","publication_identifier":{"issn":["0364-765X"],"eissn":["1526-5471"]},"abstract":[{"text":"Partially observable Markov decision processes (POMDPs) are standard models for dynamic systems with probabilistic and nondeterministic behaviour in uncertain environments. We prove that in POMDPs with long-run average objective, the decision maker has approximately optimal strategies with finite memory. This implies notably that approximating the long-run value is recursively enumerable, as well as a weak continuity property of the value with respect to the transition function. ","lang":"eng"}],"type":"journal_article","date_updated":"2026-04-07T12:31:21Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","title":"Finite-memory strategies in POMDPs with long-run average objectives","article_type":"original","oa":1,"keyword":["Management Science and Operations Research","General Mathematics","Computer Science Applications"]},{"publisher":"Institute of Science and Technology Austria","project":[{"grant_number":"708497","call_identifier":"H2020","name":"Presynaptic calcium channels distribution and impact on coupling at the hippocampal mossy fiber synapse","_id":"25BAF7B2-B435-11E9-9278-68D0E5697425"},{"call_identifier":"H2020","name":"Biophysics and circuit function of a giant cortical glutamatergic synapse","grant_number":"692692","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FWF","name":"Zellkommunikation in Gesundheit und Krankheit","grant_number":"W01205","_id":"25C3DBB6-B435-11E9-9278-68D0E5697425"},{"_id":"25C5A090-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Synaptic communication in neuronal microcircuits","grant_number":"Z00312"}],"ddc":["570"],"degree_awarded":"PhD","year":"2022","date_published":"2022-04-20T00:00:00Z","article_processing_charge":"No","page":"132","_id":"11196","alternative_title":["ISTA Thesis"],"author":[{"full_name":"Kim, Olena","id":"3F8ABDDA-F248-11E8-B48F-1D18A9856A87","last_name":"Kim","orcid":"0000-0003-2344-1039","first_name":"Olena"}],"status":"public","file":[{"file_name":"Olena_KIM_thesis_final.pdf","date_created":"2022-04-20T14:21:56Z","file_id":"11220","creator":"okim","file_size":21273537,"embargo":"2023-04-19","date_updated":"2023-04-20T22:30:03Z","access_level":"open_access","checksum":"1616a8bf6f13a57c892dac873dcd0936","relation":"main_file","content_type":"application/pdf"},{"date_created":"2022-04-20T14:22:56Z","file_id":"11221","file_name":"KIM_thesis_final.zip","date_updated":"2023-04-20T22:30:03Z","file_size":59248569,"creator":"okim","access_level":"closed","embargo_to":"open_access","content_type":"application/x-zip-compressed","relation":"source_file","checksum":"1acb433f98dc42abb0b4b0cbb0c4b918"}],"citation":{"short":"O. Kim, Nanoarchitecture of Hippocampal Mossy Fiber-CA3 Pyramidal Neuron Synapses, Institute of Science and Technology Austria, 2022.","chicago":"Kim, Olena. “Nanoarchitecture of Hippocampal Mossy Fiber-CA3 Pyramidal Neuron Synapses.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:11196.","mla":"Kim, Olena. Nanoarchitecture of Hippocampal Mossy Fiber-CA3 Pyramidal Neuron Synapses. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:11196.","ista":"Kim O. 2022. Nanoarchitecture of hippocampal mossy fiber-CA3 pyramidal neuron synapses. Institute of Science and Technology Austria.","ieee":"O. Kim, “Nanoarchitecture of hippocampal mossy fiber-CA3 pyramidal neuron synapses,” Institute of Science and Technology Austria, 2022.","ama":"Kim O. Nanoarchitecture of hippocampal mossy fiber-CA3 pyramidal neuron synapses. 2022. doi:10.15479/at:ista:11196","apa":"Kim, O. (2022). Nanoarchitecture of hippocampal mossy fiber-CA3 pyramidal neuron synapses. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:11196"},"tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"month":"04","corr_author":"1","related_material":{"record":[{"id":"7473","relation":"part_of_dissertation","status":"public"},{"relation":"part_of_dissertation","id":"11222","status":"public"}]},"ec_funded":1,"doi":"10.15479/at:ista:11196","day":"20","publication_status":"published","department":[{"_id":"PeJo"},{"_id":"GradSch"}],"acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"PreCl"}],"language":[{"iso":"eng"}],"oa_version":"Published Version","abstract":[{"lang":"eng","text":"One of the fundamental questions in Neuroscience is how the structure of synapses and their physiological properties are related. While synaptic transmission remains a dynamic process, electron microscopy provides images with comparably low temporal resolution (Studer et al., 2014). The current work overcomes this challenge and describes an improved “Flash and Freeze” technique (Watanabe et al., 2013a; Watanabe et al., 2013b) to study synaptic transmission at the hippocampal mossy fiber-CA3 pyramidal neuron synapses, using mouse acute brain slices and organotypic slices culture. The improved method allowed for selective stimulation of presynaptic mossy fiber boutons and the observation of synaptic vesicle pool dynamics at the active zones. Our results uncovered several intriguing morphological features of mossy fiber boutons. First, the docked vesicle pool was largely depleted (more than 70%) after stimulation, implying that the docked synaptic vesicles pool and readily releasable pool are vastly overlapping in mossy fiber boutons. Second, the synaptic vesicles are skewed towards larger diameters, displaying a wide range of sizes. An increase in the mean diameter of synaptic vesicles, after single and repetitive stimulation, suggests that smaller vesicles have a higher release probability. Third, we observed putative endocytotic structures after moderate light stimulation, matching the timing of previously described ultrafast endocytosis (Watanabe et al., 2013a; Delvendahl et al., 2016). \r\n\tIn addition, synaptic transmission depends on a sophisticated system of protein machinery and calcium channels (Südhof, 2013b), which amplifies the challenge in studying synaptic communication as these interactions can be potentially modified during synaptic plasticity. And although recent study elucidated the potential correlation between physiological and morphological properties of synapses during synaptic plasticity (Vandael et al., 2020), the molecular underpinning of it remains unknown. Thus, the presented work tries to overcome this challenge and aims to pinpoint changes in the molecular architecture at hippocampal mossy fiber bouton synapses during short- and long-term potentiation (STP and LTP), we combined chemical potentiation, with the application of a cyclic adenosine monophosphate agonist (i.e. forskolin) and freeze-fracture replica immunolabelling. This method allowed the localization of membrane-bound proteins with nanometer precision within the active zone, in particular, P/Q-type calcium channels and synaptic vesicle priming proteins Munc13-1/2. First, we found that the number of clusters of Munc13-1 in the mossy fiber bouton active zone increased significantly during STP, but decreased to lower than the control value during LTP. Secondly, although the distance between the calcium channels and Munc13-1s did not change after induction of STP, it shortened during the LTP phase. Additionally, forskolin did not affect Munc13-2 distribution during STP and LTP. These results indicate the existence of two distinct mechanisms that govern STP and LTP at mossy fiber bouton synapses: an increase in the readily realizable pool in the case of STP and a potential increase in release probability during LTP. “Flash and freeze” and functional electron microscopy, are versatile methods that can be successfully applied to intact brain circuits to study synaptic transmission even at the molecular level.\r\n"}],"publication_identifier":{"issn":["2663-337X"]},"supervisor":[{"first_name":"Peter M","orcid":"0000-0001-5001-4804","last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","full_name":"Jonas, Peter M"}],"date_created":"2022-04-20T09:47:12Z","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","file_date_updated":"2023-04-20T22:30:03Z","date_updated":"2026-06-18T10:49:27Z","type":"dissertation","OA_place":"publisher","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","title":"Nanoarchitecture of hippocampal mossy fiber-CA3 pyramidal neuron synapses","oa":1,"has_accepted_license":"1"}]