[{"publication_status":"epub_ahead","publisher":"Elsevier","corr_author":"1","year":"2026","type":"journal_article","title":"Tracing cell lineages in the developing brain: Insights from mosaic analysis and clone-resolved transcriptomics","OA_type":"hybrid","article_number":"102487","citation":{"ieee":"I. Varela Martínez, F. Pipicelli, and S. Hippenmeyer, “Tracing cell lineages in the developing brain: Insights from mosaic analysis and clone-resolved transcriptomics,” <i>Current Opinion in Genetics &#38; Development</i>, vol. 99. Elsevier, 2026.","short":"I. Varela Martínez, F. Pipicelli, S. Hippenmeyer, Current Opinion in Genetics &#38; Development 99 (2026).","ama":"Varela Martínez I, Pipicelli F, Hippenmeyer S. Tracing cell lineages in the developing brain: Insights from mosaic analysis and clone-resolved transcriptomics. <i>Current Opinion in Genetics &#38; Development</i>. 2026;99. doi:<a href=\"https://doi.org/10.1016/j.gde.2026.102487\">10.1016/j.gde.2026.102487</a>","ista":"Varela Martínez I, Pipicelli F, Hippenmeyer S. 2026. Tracing cell lineages in the developing brain: Insights from mosaic analysis and clone-resolved transcriptomics. Current Opinion in Genetics &#38; Development. 99, 102487.","apa":"Varela Martínez, I., Pipicelli, F., &#38; Hippenmeyer, S. (2026). Tracing cell lineages in the developing brain: Insights from mosaic analysis and clone-resolved transcriptomics. <i>Current Opinion in Genetics &#38; Development</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.gde.2026.102487\">https://doi.org/10.1016/j.gde.2026.102487</a>","chicago":"Varela Martínez, Irene, Fabrizia Pipicelli, and Simon Hippenmeyer. “Tracing Cell Lineages in the Developing Brain: Insights from Mosaic Analysis and Clone-Resolved Transcriptomics.” <i>Current Opinion in Genetics &#38; Development</i>. Elsevier, 2026. <a href=\"https://doi.org/10.1016/j.gde.2026.102487\">https://doi.org/10.1016/j.gde.2026.102487</a>.","mla":"Varela Martínez, Irene, et al. “Tracing Cell Lineages in the Developing Brain: Insights from Mosaic Analysis and Clone-Resolved Transcriptomics.” <i>Current Opinion in Genetics &#38; Development</i>, vol. 99, 102487, Elsevier, 2026, doi:<a href=\"https://doi.org/10.1016/j.gde.2026.102487\">10.1016/j.gde.2026.102487</a>."},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.gde.2026.102487"}],"date_created":"2026-06-07T22:01:35Z","volume":99,"scopus_import":"1","day":"29","abstract":[{"text":"The cerebral cortex comprises diverse neuron and glial cell types generated by radial glial progenitors (RGPs) during development. Although RGPs broadly differentiate according to temporally and spatially regulated molecular logics, the lineage hierarchies linking individual progenitors to defined cell (sub)types are not well understood. Clone-resolved transcriptomics, combining molecular barcoding and single-cell RNA sequencing, allow high-resolution lineage tracing at the single-clone/cell level across different species and models. In this mini-review, we synthesize recent advances in this field, uncovering unexpected lineage relationships in the developing brain, with a particular focus on the cerebral cortex. We further highlight new insights into species-specific differences in the developmental programs generating cell-type diversity, linking changes in clonal architecture to lineage diversification during cortical evolution.","lang":"eng"}],"date_updated":"2026-08-12T09:56:19Z","month":"05","external_id":{"pmid":["42214837"]},"article_type":"original","PlanS_conform":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"pmid":1,"intvolume":"        99","quality_controlled":"1","oa_version":"Published Version","has_accepted_license":"1","author":[{"id":"a69b5985-8829-11f0-8fc2-d0af58f64471","last_name":"Varela Martínez","first_name":"Irene","full_name":"Varela Martínez, Irene"},{"id":"649134fd-d012-11ed-8f82-db1e5050f9ba","full_name":"Pipicelli, Fabrizia","last_name":"Pipicelli","first_name":"Fabrizia"},{"last_name":"Hippenmeyer","first_name":"Simon","full_name":"Hippenmeyer, Simon","orcid":"0000-0003-2279-1061","id":"37B36620-F248-11E8-B48F-1D18A9856A87"}],"_id":"21948","ddc":["570"],"publication":"Current Opinion in Genetics & Development","publication_identifier":{"issn":["0959-437X"],"eissn":["1879-0380"]},"doi":"10.1016/j.gde.2026.102487","date_published":"2026-05-29T00:00:00Z","department":[{"_id":"SiHi"}],"acknowledgement":"We wish to thank all members of the Hippenmeyer laboratory at ISTA for exciting discussions on the subject of this review. We apologize to colleagues whose work we could not cite and/or discuss in the frame of the available space. Work in the Hippenmeyer laboratory on the discussed topic is supported by ISTA institutional funds, an EMBO LTF (ALTF 994–2023) to F.P., FWF SFB F78 (10.55776/F78) to S.H., and FWF Cluster of Excellence COE16 (10.55776/COE16) to S.H.","language":[{"iso":"eng"}],"project":[{"grant_number":"ALTF 994-2023","_id":"7c084566-9f16-11ee-852c-c88a1dbbf1cf","name":"Role of cell lineage in generating cell-type diversity in developing neocortex’"},{"grant_number":"F7805","_id":"059F6AB4-7A3F-11EA-A408-12923DDC885E","name":"Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular Mechanisms of Neural Stem Cell Lineage Progression"}],"article_processing_charge":"Yes (via OA deal)","OA_place":"publisher"},{"article_processing_charge":"No","OA_place":"repository","acknowledgement":"We thank Pierre Léopold, Tatsushi Igaki, Erik Storkebaum, Tobias Reiff, Masayuki Miura, Xiaohang Yang, Mikio Furuse, Bloomington Drosophila Stock Center and Developmental Studies Hybridoma Bank for providing us with fly stocks and reagents. We are also grateful to Hiromi Yanagisawa, Satoru Kobayashi, Md Al Amin Sheikh and Yaxuan Cui for allowing us to use their equipment, and to Allison Bardin, Pierre Léopold and Tadashi Uemura for helpful discussions.","language":[{"iso":"eng"}],"doi":"10.1242/dev.205225","department":[{"_id":"XiFe"}],"date_published":"2026-01-15T00:00:00Z","publication":"Development","publication_identifier":{"issn":["0950-1991"],"eissn":["1477-9129"]},"_id":"21039","author":[{"first_name":"Qingyin","last_name":"Qian","full_name":"Qian, Qingyin"},{"id":"608df3e6-e2ab-11ed-8890-c9318cec7da4","last_name":"Nagai","first_name":"Hiroki","orcid":"0000-0003-1671-9434","full_name":"Nagai, Hiroki"},{"full_name":"Sanaki, Yuya","last_name":"Sanaki","first_name":"Yuya"},{"full_name":"Hayashi, Makoto","last_name":"Hayashi","first_name":"Makoto"},{"full_name":"Kimura, Kenichi","last_name":"Kimura","first_name":"Kenichi"},{"full_name":"Nakajima, Yu Ichiro","first_name":"Yu Ichiro","last_name":"Nakajima"},{"last_name":"Niwa","first_name":"Ryusuke","full_name":"Niwa, Ryusuke"}],"quality_controlled":"1","oa_version":"Preprint","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"intvolume":"       153","pmid":1,"article_type":"original","status":"public","external_id":{"pmid":["41392708"]},"month":"01","date_updated":"2026-08-12T10:01:56Z","abstract":[{"text":"Cellular plasticity, the ability of a differentiated cell to adopt another phenotypic identity, is restricted under basal conditions, but can be elicited upon damage. However, the molecular mechanism enabling such plasticity remains largely unexplored. Here, we report damage-induced cellular plasticity of secretory enteroendocrine cells (EEs) in the adult Drosophila midgut. Ionizing radiation induces EE fate conversion and activates stress-responsive programs in EE lineages, accompanied by the induction of the stress-inducible transcription factor Xrp1 and the cytokine gene upd3. Xrp1 and upd3 are both necessary for radiation-induced EE plasticity. Under basal conditions, EE-specific Xrp1 overexpression triggers ectopic expression of progenitor-specific genes, which is necessary for Xrp1 to drive EE plasticity. Our work identifies Xrp1 as a crucial regulator that coordinates damage-induced signaling and transcriptional reprogramming, enabling the reactivation of cellular plasticity in differentiated cells.","lang":"eng"}],"day":"15","scopus_import":"1","date_created":"2026-01-25T23:01:39Z","volume":153,"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2025.07.05.662934"}],"OA_type":"green","citation":{"ista":"Qian Q, NAGAI H, Sanaki Y, Hayashi M, Kimura K, Nakajima YI, Niwa R. 2026. Xrp1 drives damage-induced cellular plasticity of enteroendocrine cells in the adult Drosophila midgut. Development. 153(2), dev205225.","apa":"Qian, Q., NAGAI, H., Sanaki, Y., Hayashi, M., Kimura, K., Nakajima, Y. I., &#38; Niwa, R. (2026). Xrp1 drives damage-induced cellular plasticity of enteroendocrine cells in the adult Drosophila midgut. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.205225\">https://doi.org/10.1242/dev.205225</a>","ama":"Qian Q, NAGAI H, Sanaki Y, et al. Xrp1 drives damage-induced cellular plasticity of enteroendocrine cells in the adult Drosophila midgut. <i>Development</i>. 2026;153(2). doi:<a href=\"https://doi.org/10.1242/dev.205225\">10.1242/dev.205225</a>","short":"Q. Qian, H. NAGAI, Y. Sanaki, M. Hayashi, K. Kimura, Y.I. Nakajima, R. Niwa, Development 153 (2026).","mla":"Qian, Qingyin, et al. “Xrp1 Drives Damage-Induced Cellular Plasticity of Enteroendocrine Cells in the Adult Drosophila Midgut.” <i>Development</i>, vol. 153, no. 2, dev205225, Company of Biologists, 2026, doi:<a href=\"https://doi.org/10.1242/dev.205225\">10.1242/dev.205225</a>.","chicago":"Qian, Qingyin, HIROKI NAGAI, Yuya Sanaki, Makoto Hayashi, Kenichi Kimura, Yu Ichiro Nakajima, and Ryusuke Niwa. “Xrp1 Drives Damage-Induced Cellular Plasticity of Enteroendocrine Cells in the Adult Drosophila Midgut.” <i>Development</i>. Company of Biologists, 2026. <a href=\"https://doi.org/10.1242/dev.205225\">https://doi.org/10.1242/dev.205225</a>.","ieee":"Q. Qian <i>et al.</i>, “Xrp1 drives damage-induced cellular plasticity of enteroendocrine cells in the adult Drosophila midgut,” <i>Development</i>, vol. 153, no. 2. Company of Biologists, 2026."},"article_number":"dev205225","issue":"2","type":"journal_article","title":"Xrp1 drives damage-induced cellular plasticity of enteroendocrine cells in the adult Drosophila midgut","year":"2026","publisher":"Company of Biologists","publication_status":"published"},{"has_accepted_license":"1","author":[{"full_name":"Zhao, Ziyu","first_name":"Ziyu","last_name":"Zhao","id":"a63fe682-9f3a-11ee-bf8c-cfdf919b9850"},{"orcid":"0000-0002-0977-7989","full_name":"Sazanov, Leonid A","last_name":"Sazanov","first_name":"Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87"}],"_id":"22148","acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"ScienComp"}],"supplementarymaterial":"yes","publication_identifier":{"issn":["1097-2765"],"eissn":["1097-4164"]},"publication":"Molecular Cell","ddc":["570"],"doi":"10.1016/j.molcel.2026.05.026","department":[{"_id":"LeSa"}],"date_published":"2026-06-22T00:00:00Z","language":[{"iso":"eng"}],"acknowledgement":"We thank IST Austria for providing the funding. We thank IST Austria EM facility for the use of Titan Krios TEM. Data processing was performed using IST high-performance computer cluster. We thank Dr. R. Roemhild and Professor C. Guet (ISTA) for help in constructing Tat deletion strains and Dr. A. Charnagalov (ISTA) for technical help.","article_processing_charge":"Yes (via OA deal)","OA_place":"publisher","date_updated":"2026-08-12T12:08:44Z","abstract":[{"lang":"eng","text":"How the twin-arginine translocase (Tat) system transports fully folded substrate proteins across cellular membranes without disrupting membrane integrity has been a fundamental question in cell biology for decades. The Tat system, found in prokaryotes and plant organelles, recognizes a cargo signal peptide via a conserved twin-arginine motif. The multi-subunit Tat complex facilitates the proton-motive-force-dependent translocation process, yet its overall architecture has remained unknown. Here, we present the cryo-electron microscopy (cryo-EM) structure of the Escherichia coli (E. coli) trimeric TatB₃C₃ complex with bound substrate SufI, assembled in vivo. The complex adopts an unusual, wide-open, bowl-shaped architecture with a polar inner cavity. Unexpectedly, the cargo is engaged in a dual-contact mode: while the signal peptide binds inside one TatBC unit, the folded domain docks tightly onto an adjacent unit, possibly performing a proofreading function. This structure provides a mechanistic framework for substrate engagement and suggests the direct involvement of the entire Tat complex in substrate translocation."}],"month":"06","dataavailabilitystatement":"This study did not generate new unique reagents. Strains and plasmids generated in this study are available from the lead contact without restrictions.\r\n• Source data are provided within this paper. The cryo-EM map is deposited in the Electron Microscopy Data Bank under accession number EMD-53848. The model is deposited in the Protein Data Bank under accession number 9R91. The structural data are publicly available as of the date of publication. Raw images of spot assays, SDS-PAGE and BN-PAGE gels with Coomassie staining and immunoblot images are available at Mendeley Data (https://doi.org/10.17632/v2g3p9n985.1).\r\n• This paper does not report original code.\r\n• Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.","external_id":{"biorxivid":["10.1101/2025.09.16.676506"]},"article_type":"original","researchdata_availability":"yes","tmp":{"image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"status":"public","license":"https://creativecommons.org/licenses/by-nc/4.0/","related_material":{"link":[{"description":"News on ISTA website","relation":"press_release","url":"https://ista.ac.at/en/news/the-gate-for-bulky-cargo/"}],"record":[{"relation":"research_data","id":"22189","status":"public"}]},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"quality_controlled":"1","oa_version":"Published Version","OA_type":"hybrid","citation":{"ieee":"Z. Zhao and L. A. Sazanov, “Structure of E. Coli twin-arginine translocase (Tat) complex with bound cargo,” <i>Molecular Cell</i>. Elsevier.","ama":"Zhao Z, Sazanov LA. Structure of E. Coli twin-arginine translocase (Tat) complex with bound cargo. <i>Molecular Cell</i>. doi:<a href=\"https://doi.org/10.1016/j.molcel.2026.05.026\">10.1016/j.molcel.2026.05.026</a>","short":"Z. Zhao, L.A. Sazanov, Molecular Cell (n.d.).","apa":"Zhao, Z., &#38; Sazanov, L. A. (n.d.). Structure of E. Coli twin-arginine translocase (Tat) complex with bound cargo. <i>Molecular Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.molcel.2026.05.026\">https://doi.org/10.1016/j.molcel.2026.05.026</a>","ista":"Zhao Z, Sazanov LA. Structure of E. Coli twin-arginine translocase (Tat) complex with bound cargo. Molecular Cell.","chicago":"Zhao, Ziyu, and Leonid A Sazanov. “Structure of E. Coli Twin-Arginine Translocase (Tat) Complex with Bound Cargo.” <i>Molecular Cell</i>. Elsevier, n.d. <a href=\"https://doi.org/10.1016/j.molcel.2026.05.026\">https://doi.org/10.1016/j.molcel.2026.05.026</a>.","mla":"Zhao, Ziyu, and Leonid A. Sazanov. “Structure of E. Coli Twin-Arginine Translocase (Tat) Complex with Bound Cargo.” <i>Molecular Cell</i>, Elsevier, doi:<a href=\"https://doi.org/10.1016/j.molcel.2026.05.026\">10.1016/j.molcel.2026.05.026</a>."},"main_file_link":[{"url":"https://doi.org/10.1016/j.molcel.2026.05.026","open_access":"1"}],"das_tickbox":"1","date_created":"2026-06-28T22:01:35Z","scopus_import":"1","day":"22","publication_status":"inpress","publisher":"Elsevier","corr_author":"1","year":"2026","type":"journal_article","title":"Structure of E. Coli twin-arginine translocase (Tat) complex with bound cargo","biorxivid":1},{"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"status":"public","title":"Structure of E. coli twin-arginine translocase (Tat) complex with bound cargo. Zhao et al.","keyword":["Protein Purification"],"type":"research_data_reference","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","related_material":{"record":[{"status":"public","id":"22148","relation":"used_in_publication"}]},"oa":1,"year":"2026","corr_author":"1","date_updated":"2026-08-12T12:08:44Z","abstract":[{"text":"Raw images for SDS and Blue Native gels, western blots and spot growth assays, related to figures S1 and S2.","lang":"eng"}],"publisher":"Mendeley Data","month":"05","article_processing_charge":"No","OA_place":"publisher","day":"15","department":[{"_id":"LeSa"}],"date_published":"2026-05-15T00:00:00Z","doi":"10.17632/V2G3P9N985.1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.17632/v2g3p9n985.1"}],"ddc":["570"],"date_created":"2026-06-29T12:54:45Z","author":[{"id":"338D39FE-F248-11E8-B48F-1D18A9856A87","last_name":"Sazanov","first_name":"Leonid A","full_name":"Sazanov, Leonid A","orcid":"0000-0002-0977-7989"}],"has_accepted_license":"1","OA_type":"gold","citation":{"short":"L.A. Sazanov, (2026).","ama":"Sazanov LA. Structure of E. coli twin-arginine translocase (Tat) complex with bound cargo. Zhao et al. 2026. doi:<a href=\"https://doi.org/10.17632/V2G3P9N985.1\">10.17632/V2G3P9N985.1</a>","apa":"Sazanov, L. A. (2026). Structure of E. coli twin-arginine translocase (Tat) complex with bound cargo. Zhao et al. Mendeley Data. <a href=\"https://doi.org/10.17632/V2G3P9N985.1\">https://doi.org/10.17632/V2G3P9N985.1</a>","ista":"Sazanov LA. 2026. Structure of E. coli twin-arginine translocase (Tat) complex with bound cargo. Zhao et al., Mendeley Data, <a href=\"https://doi.org/10.17632/V2G3P9N985.1\">10.17632/V2G3P9N985.1</a>.","chicago":"Sazanov, Leonid A. “Structure of E. Coli Twin-Arginine Translocase (Tat) Complex with Bound Cargo. Zhao et Al.” Mendeley Data, 2026. <a href=\"https://doi.org/10.17632/V2G3P9N985.1\">https://doi.org/10.17632/V2G3P9N985.1</a>.","mla":"Sazanov, Leonid A. <i>Structure of E. Coli Twin-Arginine Translocase (Tat) Complex with Bound Cargo. Zhao et Al.</i> Mendeley Data, 2026, doi:<a href=\"https://doi.org/10.17632/V2G3P9N985.1\">10.17632/V2G3P9N985.1</a>.","ieee":"L. A. Sazanov, “Structure of E. coli twin-arginine translocase (Tat) complex with bound cargo. Zhao et al.” Mendeley Data, 2026."},"_id":"22189"},{"oa_version":"None","oa":1,"user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","type":"research_data","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png"},"status":"public","title":"Asymmetrical modulation of fear expression via GABAB receptors in the mouse medial habenula","file_date_updated":"2026-08-13T13:06:29Z","corr_author":"1","year":"2026","month":"08","publisher":"Institute of Science and Technology Austria","abstract":[{"lang":"eng","text":"The medial habenula (MHb) is implicated in regulating emotional responses to aversive events. Studies in zebrafish have identified a remarkable morphological left–right asymmetry in the dorsal habenula (zebrafish equivalent of mammalian MHb)-interpeduncular nucleus (IPN) pathway and its asymmetrical roles in behavior. However, there is little evidence for structural or functional lateralization in the mammalian MHb-IPN pathway. Here, we investigated the synaptic properties of left- and right-MHb afferents to the IPN and their roles in the expression of conditioned fear in mice. We found that each IPN neuron receives inputs from both left and right MHb, but the left MHb-originating synapses exhibit lower release probability and higher γ-aminobutyric acid type B receptor (GABABR)-mediated potentiation compared to the right MHb-originating synapses. Interestingly, these asymmetrical properties persist in the inversus visceral mutant mice with normal internal organ laterality (situs solitus), but nearly disappear in those with reversed internal organ laterality (situs inversus). Behaviorally, chemogenetic inhibition of cholinergic neurons and conditional deletion of GABABR in the left, but not the right, MHb significantly attenuated cue-dependent fear recall. Our results demonstrate functional asymmetry of the MHb under partial influence of the nodal flow in mice, revealing a predominant role of GABABR-mediated signaling in the left MHb-IPN pathway in modulating fear memories. These findings suggest that lateralized MHb pathways could represent a fundamental principle in the neural regulation of emotion across species but that they develop differently in zebrafish and mice.\r\n"}],"date_updated":"2026-08-13T13:30:37Z","project":[{"grant_number":"665385","call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program"},{"_id":"92503f6e-16d5-11f0-9cad-8c571927f3b7","name":"New regime of presynaptic release regulation","grant_number":"PAT 5720324"}],"day":"13","file":[{"file_name":"Behavior.zip","success":1,"file_size":162086,"date_updated":"2026-08-13T12:07:53Z","relation":"main_file","checksum":"7742bb211a43bb87c2b5ce7bda3068ae","file_id":"22705","content_type":"application/x-zip-compressed","creator":"elemonni","date_created":"2026-08-13T12:07:53Z","access_level":"open_access"},{"success":1,"file_name":"image_analysis.zip","access_level":"open_access","creator":"elemonni","date_created":"2026-08-13T12:07:57Z","content_type":"application/x-zip-compressed","checksum":"a162eb6103a770d94536374e02934fcf","file_id":"22706","file_size":6643,"date_updated":"2026-08-13T12:07:57Z","relation":"main_file"},{"file_name":"Recordings.zip","success":1,"file_size":1193016,"date_updated":"2026-08-13T12:07:59Z","relation":"main_file","date_created":"2026-08-13T12:07:59Z","creator":"elemonni","access_level":"open_access","checksum":"608aaf395bba5fd9cf62d8c8940d63aa","content_type":"application/x-zip-compressed","file_id":"22707"},{"file_name":"README.txt","success":1,"file_size":246,"date_updated":"2026-08-13T13:06:29Z","relation":"main_file","access_level":"open_access","date_created":"2026-08-13T13:06:29Z","creator":"elemonni","file_id":"22708","checksum":"2389ebd71238bd7de03d20504a8cf962","content_type":"text/plain"}],"article_processing_charge":"No","OA_place":"repository","ec_funded":1,"doi":"10.15479/AT-ISTA-22704","department":[{"_id":"RySh"}],"date_published":"2026-08-13T00:00:00Z","acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"PreCl"}],"date_created":"2026-08-13T12:20:08Z","_id":"22704","citation":{"apa":"Le Monnier, E., &#38; Önal, C. (2026). Asymmetrical modulation of fear expression via GABAB receptors in the mouse medial habenula. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-22704\">https://doi.org/10.15479/AT-ISTA-22704</a>","ista":"Le Monnier E, Önal C. 2026. Asymmetrical modulation of fear expression via GABAB receptors in the mouse medial habenula, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-22704\">10.15479/AT-ISTA-22704</a>.","ama":"Le Monnier E, Önal C. Asymmetrical modulation of fear expression via GABAB receptors in the mouse medial habenula. 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-22704\">10.15479/AT-ISTA-22704</a>","short":"E. Le Monnier, C. Önal, (2026).","mla":"Le Monnier, Elodie, and Cihan Önal. <i>Asymmetrical Modulation of Fear Expression via GABAB Receptors in the Mouse Medial Habenula</i>. Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-22704\">10.15479/AT-ISTA-22704</a>.","chicago":"Le Monnier, Elodie, and Cihan Önal. “Asymmetrical Modulation of Fear Expression via GABAB Receptors in the Mouse Medial Habenula.” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-22704\">https://doi.org/10.15479/AT-ISTA-22704</a>.","ieee":"E. Le Monnier and C. Önal, “Asymmetrical modulation of fear expression via GABAB receptors in the mouse medial habenula.” Institute of Science and Technology Austria, 2026."},"has_accepted_license":"1","author":[{"id":"3B59276A-F248-11E8-B48F-1D18A9856A87","first_name":"Elodie","last_name":"Le Monnier","full_name":"Le Monnier, Elodie"},{"full_name":"Önal, Cihan","last_name":"Önal","first_name":"Cihan"}],"doi_confirm":"1"},{"file_date_updated":"2026-08-18T06:53:22Z","title":"Randomise alone, reach as a team","type":"conference","year":"2026","page":"215-236","publisher":"Springer Nature","publication_status":"published","day":"24","conference":{"end_date":"2026-07-29","location":"Lisbon, Portugal","start_date":"2026-07-26","name":"CAV: Computer Aided Verification"},"scopus_import":"1","ec_funded":1,"volume":16682,"date_created":"2026-08-16T22:01:44Z","das_tickbox":"1","citation":{"chicago":"Brice, Leonard J, Thomas A Henzinger, Alipasha Montaseri, Ali Shafiee, and K. S. Thejaswini. “Randomise Alone, Reach as a Team.” In <i>38th International Conference on Computer Aided Verification</i>, 16682:215–36. Springer Nature, 2026. <a href=\"https://doi.org/10.1007/978-3-032-32519-8_12\">https://doi.org/10.1007/978-3-032-32519-8_12</a>.","mla":"Brice, Leonard J., et al. “Randomise Alone, Reach as a Team.” <i>38th International Conference on Computer Aided Verification</i>, vol. 16682, Springer Nature, 2026, pp. 215–36, doi:<a href=\"https://doi.org/10.1007/978-3-032-32519-8_12\">10.1007/978-3-032-32519-8_12</a>.","short":"L.J. Brice, T.A. Henzinger, A. Montaseri, A. Shafiee, K.S. Thejaswini, in:, 38th International Conference on Computer Aided Verification, Springer Nature, 2026, pp. 215–236.","ama":"Brice LJ, Henzinger TA, Montaseri A, Shafiee A, Thejaswini KS. Randomise alone, reach as a team. In: <i>38th International Conference on Computer Aided Verification</i>. Vol 16682. Springer Nature; 2026:215-236. doi:<a href=\"https://doi.org/10.1007/978-3-032-32519-8_12\">10.1007/978-3-032-32519-8_12</a>","apa":"Brice, L. J., Henzinger, T. A., Montaseri, A., Shafiee, A., &#38; Thejaswini, K. S. (2026). Randomise alone, reach as a team. In <i>38th International Conference on Computer Aided Verification</i> (Vol. 16682, pp. 215–236). Lisbon, Portugal: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-032-32519-8_12\">https://doi.org/10.1007/978-3-032-32519-8_12</a>","ista":"Brice LJ, Henzinger TA, Montaseri A, Shafiee A, Thejaswini KS. 2026. Randomise alone, reach as a team. 38th International Conference on Computer Aided Verification. CAV: Computer Aided Verification vol. 16682, 215–236.","ieee":"L. J. Brice, T. A. Henzinger, A. Montaseri, A. Shafiee, and K. S. Thejaswini, “Randomise alone, reach as a team,” in <i>38th International Conference on Computer Aided Verification</i>, Lisbon, Portugal, 2026, vol. 16682, pp. 215–236."},"OA_type":"hybrid","arxiv":1,"oa_version":"Published Version","quality_controlled":"1","intvolume":"     16682","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"researchdata_availability":"yes","external_id":{"arxiv":["2603.07094"]},"dataavailabilitystatement":"The artifact can be accessed at the link: https://doi. org/10.5281/zenodo.19680359.\r\nThe source code is available at:https://github.com/alipashamontaseri/Team-Concurrent-Game.","month":"07","abstract":[{"lang":"eng","text":"We study concurrent graph games where n players cooperate against an opponent to reach a set of target states. Unlike traditional settings, we study distributed randomisation: team players do not share a source of randomness, and their private random sources are hidden from the opponent and from each other.\r\n\r\nWe show that memoryless strategies are sufficient for the threshold problem (deciding whether there is a strategy for the team that ensures winning with probability that exceeds a threshold), a result that not only places the problem in the Existential Theory of the Reals (ER) but also enables the construction of value iteration algorithms. We additionally show that the threshold problem is NP-hard. For the almost-sure reachability problem, we prove NP-completeness.\r\n\r\nWe introduce Individually Randomised Alternating-time Temporal Logic (IRATL). This logic extends the standard ATL framework to reason about probability thresholds, with semantics explicitly designed for coalitions that lack a shared source of randomness. On the practical side, we implement and evaluate a solver for the threshold and almost-sure problem based on the algorithms that we develop."}],"date_updated":"2026-08-18T06:55:38Z","article_processing_charge":"Yes (in subscription journal)","OA_place":"publisher","file":[{"success":1,"file_name":"2026_LNCS_Brice.pdf","date_created":"2026-08-18T06:53:22Z","access_level":"open_access","creator":"dernst","file_id":"22724","checksum":"10ded8a3ab9ed34c9e4794c0b277622c","content_type":"application/pdf","file_size":1902192,"relation":"main_file","date_updated":"2026-08-18T06:53:22Z"}],"project":[{"call_identifier":"H2020","grant_number":"101020093","name":"Vigilant Algorithmic Monitoring of Software","_id":"62781420-2b32-11ec-9570-8d9b63373d4d"}],"acknowledgement":"This work is a part of project VAMOS that has received funding from the European Research Council (ERC), grant agreement No 101020093. Part of this work was realised when the first author was an FNRS aspirant at Université libre de Bruxelles.","language":[{"iso":"eng"}],"date_published":"2026-07-24T00:00:00Z","department":[{"_id":"ToHe"},{"_id":"GradSch"}],"doi":"10.1007/978-3-032-32519-8_12","publication":"38th International Conference on Computer Aided Verification","publication_identifier":{"issn":["0302-9743"],"isbn":["9783032325181"],"eissn":["1611-3349"]},"ddc":["000"],"supplementarymaterial":"no","_id":"22717","author":[{"full_name":"Brice, Leonard J","first_name":"Leonard J","last_name":"Brice","id":"ce3b3409-db6c-11f0-aa64-ad678f7fd937"},{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas A","last_name":"Henzinger","orcid":"0000-0002-2985-7724","full_name":"Henzinger, Thomas A"},{"id":"709a7f96-8896-11f0-9809-d75612fc0f2e","first_name":"Alipasha","last_name":"Montaseri","full_name":"Montaseri, Alipasha"},{"id":"2783031a-7378-11f0-b2d0-f17f1db2ebad","first_name":"Ali","last_name":"Shafiee","full_name":"Shafiee, Ali"},{"first_name":"K. S.","last_name":"Thejaswini","full_name":"Thejaswini, K. S."}],"has_accepted_license":"1"},{"has_accepted_license":"1","author":[{"id":"11d88cf5-91ca-11f0-a95f-edf9f08f47b7","last_name":"Bojan","first_name":"Meital I","full_name":"Bojan, Meital I"},{"last_name":"Vedula","first_name":"Sanketh","full_name":"Vedula, Sanketh"},{"first_name":"Sai A","last_name":"Maddipatla","full_name":"Maddipatla, Sai A","id":"e957f5e5-91c9-11f0-a95f-e090f66ecb4d"},{"id":"ef280fe0-91c9-11f0-a95f-8dea3f5bc513","first_name":"Nadav E","last_name":"Sellam","full_name":"Sellam, Nadav E"},{"last_name":"Rzayev","first_name":"Anar","full_name":"Rzayev, Anar","id":"2cd60677-9acd-11f1-ae1a-a85ae1c4dd35"},{"id":"d42e08e7-f4fc-11eb-af0a-d71e26138f1b","full_name":"Napoli, Federico","orcid":"0000-0002-9043-136X","first_name":"Federico","last_name":"Napoli"},{"id":"7B541462-FAF6-11E9-A490-E8DFE5697425","full_name":"Schanda, Paul","orcid":"0000-0002-9350-7606","first_name":"Paul","last_name":"Schanda"},{"id":"58f3726e-7cba-11ef-ad8b-e6e8cb3904e6","full_name":"Bronstein, Alexander","orcid":"0000-0001-9699-8730","first_name":"Alexander","last_name":"Bronstein"}],"_id":"22722","acknowledged_ssus":[{"_id":"ScienComp"}],"supplementarymaterial":"yes","publication":"14th International Conference on Learning Representations","ddc":["000","570"],"department":[{"_id":"GradSch"},{"_id":"PaSc"},{"_id":"AlBr"}],"date_published":"2026-05-01T00:00:00Z","language":[{"iso":"eng"}],"acknowledgement":"This work was supported by the Institute of Science and Technology Austria (ISTA) through the IPC\r\ngrant “Generative Protein NMR” and by the Israeli Science Foundation (ISF) under grant number\r\n1834/24. This research used resources of the Institute of Science and Technology Austria’s scientific\r\ncomputing cluster. S.V. was supported in part by funding from the Eric and Wendy Schmidt Center at\r\nthe Broad Institute of MIT and Harvard.","file":[{"success":1,"file_name":"2026_ICLR_Bojan.pdf","checksum":"9f43f5469443388ec55388d95c4cf243","file_id":"22723","content_type":"application/pdf","date_created":"2026-08-18T06:33:14Z","access_level":"open_access","creator":"dernst","file_size":8534339,"date_updated":"2026-08-18T06:33:14Z","relation":"main_file"}],"OA_place":"publisher","article_processing_charge":"No","abstract":[{"lang":"eng","text":"The local structure of a protein strongly impacts its function and interactions\r\nwith other molecules. Representing local biomolecular environments remains a\r\nkey challenge while applying machine learning approaches over protein structures. The structural and chemical variability of these environments makes them\r\nchallenging to model, and performing representation learning on these objects\r\nremains largely under-explored. In this work, we propose representations for\r\nlocal protein environments that leverage intermediate features from machine learning force fields (MLFFs). We extensively benchmark state-of-the-art MLFFs,\r\ncomparing their performance across latent spaces and downstream tasks, and\r\nshow that their embeddings capture local structural (e.g., secondary motifs) and\r\nchemical features (e.g., amino acid identity and protonation state), organizing\r\nprotein environments into a structured manifold. We show that these representations enable zero-shot generalization and transfer across diverse downstream\r\ntasks. As a case study, we build a physics-informed, uncertainty-aware chemical shift predictor that achieves state-of-the-art accuracy in biomolecular NMR\r\nspectroscopy. Our results establish MLFFs as general-purpose, reusable representation learners for protein modeling, opening new directions in representation learning for structured physical systems. Code and data are available at\r\nhttps://github.com/mb012/MLFF_representation.\r\n"}],"date_updated":"2026-08-18T06:36:55Z","month":"05","dataavailabilitystatement":"The code, trained models, and data-processing scripts are publicly available at https://github.\r\ncom/mb012/MLFF_representation. In addition, complete details of the models and optimization parameters are provided in Appendix G.3. The hardware resources used to produce the\r\nresults are specified in Appendix I.4. The loss functions, evaluation metrics, and details regarding\r\nablation studies are specified in Appendix G. These details ensure that all results reported in the paper\r\ncan be independently verified.","external_id":{"arxiv":["2505.23354"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"researchdata_availability":"yes","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"related_material":{"link":[{"url":"https://github.com/mb012/MLFF_representation","relation":"software"}]},"intvolume":"      2026","quality_controlled":"1","oa_version":"Published Version","arxiv":1,"citation":{"ama":"Bojan MI, Vedula S, Maddipatla SA, et al. Representing local protein environments with machine learning force fields. In: <i>14th International Conference on Learning Representations</i>. Vol 2026. ; 2026:100760-100799.","short":"M.I. Bojan, S. Vedula, S.A. Maddipatla, N.E. Sellam, A. Rzayev, F. Napoli, P. Schanda, A.M. Bronstein, in:, 14th International Conference on Learning Representations, 2026, pp. 100760–100799.","ista":"Bojan MI, Vedula S, Maddipatla SA, Sellam NE, Rzayev A, Napoli F, Schanda P, Bronstein AM. 2026. Representing local protein environments with machine learning force fields. 14th International Conference on Learning Representations. ICLR: International Conference on Learning Representations vol. 2026, 100760–100799.","apa":"Bojan, M. I., Vedula, S., Maddipatla, S. A., Sellam, N. E., Rzayev, A., Napoli, F., … Bronstein, A. M. (2026). Representing local protein environments with machine learning force fields. In <i>14th International Conference on Learning Representations</i> (Vol. 2026, pp. 100760–100799). Rio de Janeiro, Brazil.","chicago":"Bojan, Meital I, Sanketh Vedula, Sai A Maddipatla, Nadav E Sellam, Anar Rzayev, Federico Napoli, Paul Schanda, and Alex M. Bronstein. “Representing Local Protein Environments with Machine Learning Force Fields.” In <i>14th International Conference on Learning Representations</i>, 2026:100760–99, 2026.","mla":"Bojan, Meital I., et al. “Representing Local Protein Environments with Machine Learning Force Fields.” <i>14th International Conference on Learning Representations</i>, vol. 2026, 2026, pp. 100760–99.","ieee":"M. I. Bojan <i>et al.</i>, “Representing local protein environments with machine learning force fields,” in <i>14th International Conference on Learning Representations</i>, Rio de Janeiro, Brazil, 2026, vol. 2026, pp. 100760–100799."},"OA_type":"gold","das_tickbox":"1","date_created":"2026-08-17T12:03:24Z","volume":2026,"conference":{"start_date":"2026-04-23","location":"Rio de Janeiro, Brazil","name":"ICLR: International Conference on Learning Representations","end_date":"2026-04-27"},"day":"01","publication_status":"published","corr_author":"1","page":"100760-100799","year":"2026","type":"conference","title":"Representing local protein environments with machine learning force fields","file_date_updated":"2026-08-18T06:33:14Z"},{"type":"conference","title":"Decoupled planning for multiple omega-regular objectives","file_date_updated":"2026-08-18T08:40:07Z","year":"2026","page":"237-257","publication_status":"published","publisher":"Springer Nature","conference":{"end_date":"2026-07-29","start_date":"2026-07-26","name":"CAV: Computer Aided Verification","location":"Lisbon, Portugal"},"day":"24","scopus_import":"1","ec_funded":1,"das_tickbox":"0","date_created":"2026-08-16T22:01:44Z","volume":16682,"OA_type":"hybrid","citation":{"ieee":"G. Avni, T. A. Henzinger, K. Mallik, S. Sadhukhan, and K. S. Thejaswini, “Decoupled planning for multiple omega-regular objectives,” in <i>38th International Conference on Computer Aided Verification</i>, Lisbon, Portugal, 2026, vol. 16682, pp. 237–257.","ama":"Avni G, Henzinger TA, Mallik K, Sadhukhan S, Thejaswini KS. Decoupled planning for multiple omega-regular objectives. In: <i>38th International Conference on Computer Aided Verification</i>. Vol 16682. Springer Nature; 2026:237-257. doi:<a href=\"https://doi.org/10.1007/978-3-032-32519-8_13\">10.1007/978-3-032-32519-8_13</a>","short":"G. Avni, T.A. Henzinger, K. Mallik, S. Sadhukhan, K.S. Thejaswini, in:, 38th International Conference on Computer Aided Verification, Springer Nature, 2026, pp. 237–257.","ista":"Avni G, Henzinger TA, Mallik K, Sadhukhan S, Thejaswini KS. 2026. Decoupled planning for multiple omega-regular objectives. 38th International Conference on Computer Aided Verification. CAV: Computer Aided Verification, LNCS, vol. 16682, 237–257.","apa":"Avni, G., Henzinger, T. A., Mallik, K., Sadhukhan, S., &#38; Thejaswini, K. S. (2026). Decoupled planning for multiple omega-regular objectives. In <i>38th International Conference on Computer Aided Verification</i> (Vol. 16682, pp. 237–257). Lisbon, Portugal: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-032-32519-8_13\">https://doi.org/10.1007/978-3-032-32519-8_13</a>","chicago":"Avni, Guy, Thomas A Henzinger, Kaushik Mallik, Suman Sadhukhan, and K. S. Thejaswini. “Decoupled Planning for Multiple Omega-Regular Objectives.” In <i>38th International Conference on Computer Aided Verification</i>, 16682:237–57. Springer Nature, 2026. <a href=\"https://doi.org/10.1007/978-3-032-32519-8_13\">https://doi.org/10.1007/978-3-032-32519-8_13</a>.","mla":"Avni, Guy, et al. “Decoupled Planning for Multiple Omega-Regular Objectives.” <i>38th International Conference on Computer Aided Verification</i>, vol. 16682, Springer Nature, 2026, pp. 237–57, doi:<a href=\"https://doi.org/10.1007/978-3-032-32519-8_13\">10.1007/978-3-032-32519-8_13</a>."},"quality_controlled":"1","oa_version":"Published Version","arxiv":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"status":"public","researchdata_availability":"no","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"intvolume":"     16682","external_id":{"arxiv":["2605.13185"]},"abstract":[{"lang":"eng","text":"We study the problem of generating paths on a graph that satisfy a collection of w-regular objectives. We propose a decoupled framework in which each objective is assigned to an independent agent that selects a local policy, while a scheduler—oblivious to the graph and objective—dynamically composes these policies into a single path. We ask when such a composition satisfies all objectives, assuming their conjunction is realizable. The framework enables modular policy design but raises fundamental compositional challenges. We show that even extremely fair deterministic schedulers do not ensure correctness, and that stochastic schedulers, while necessary, are insufficient without coordination. For safety objectives, we demonstrate that fully decentralized implementations are impossible, and we introduce a protocol for synchronizing on maximal safe actions. For non-safety objectives, we introduce conventions—simple, a priori restrictions agreed upon before the graph or objectives are revealed—that guarantee satisfaction of all objectives when followed by all agents. We characterize minimally restrictive conventions for major subclasses of w-regular objectives. In particular, Büchi objectives admit universal composition of finite-memory policies without scheduler communication; co-Büchi objectives require only knowledge of whether the agent was scheduled; and parity objectives additionally require knowledge of which agent was scheduled."}],"date_updated":"2026-08-18T08:41:44Z","month":"07","project":[{"grant_number":"101020093","call_identifier":"H2020","_id":"62781420-2b32-11ec-9570-8d9b63373d4d","name":"Vigilant Algorithmic Monitoring of Software"}],"file":[{"file_name":"2026_LNCS_Avni.pdf","success":1,"date_updated":"2026-08-18T08:40:07Z","relation":"main_file","file_size":531980,"access_level":"open_access","creator":"dernst","date_created":"2026-08-18T08:40:07Z","file_id":"22730","checksum":"f17ba3f82854fdb4eb69fd922965661a","content_type":"application/pdf"}],"article_processing_charge":"Yes (in subscription journal)","OA_place":"publisher","doi":"10.1007/978-3-032-32519-8_13","department":[{"_id":"ToHe"}],"date_published":"2026-07-24T00:00:00Z","language":[{"iso":"eng"}],"acknowledgement":"This work is funded by the following grants: European Research Council under Grant No.: ERC-2020-AdG 101020093, ISF grant no. 1679/21, grant RYC2024-049116, MICIU/AEI/10.13039/501100011033, the ESF+, and Volkswagen Foundation within its Momentum framework under project no. 9C283.","supplementarymaterial":"no","publication":"38th International Conference on Computer Aided Verification","publication_identifier":{"issn":["0302-9743"],"eissn":["1611-3349"],"isbn":["9783032325181"]},"ddc":["000"],"has_accepted_license":"1","author":[{"id":"463C8BC2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5588-8287","full_name":"Avni, Guy","last_name":"Avni","first_name":"Guy"},{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas A","last_name":"Henzinger","full_name":"Henzinger, Thomas A","orcid":"0000-0002-2985-7724"},{"id":"0834ff3c-6d72-11ec-94e0-b5b0a4fb8598","orcid":"0000-0001-9864-7475","full_name":"Mallik, Kaushik","last_name":"Mallik","first_name":"Kaushik"},{"full_name":"Sadhukhan, Suman","last_name":"Sadhukhan","first_name":"Suman"},{"full_name":"Thejaswini, K. S.","last_name":"Thejaswini","first_name":"K. S."}],"_id":"22719","alternative_title":["LNCS"]},{"intvolume":"      1007","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"researchdata_availability":"no","status":"public","PlanS_conform":"1","article_type":"original","arxiv":1,"oa_version":"Published Version","quality_controlled":"1","month":"08","abstract":[{"text":"Ground-based gravitational-wave (GW) observatories have detected approximately 200 binary black hole (BH) mergers. The astrophysical origin of these events is debated, with evidence suggesting that at least a subset originated from dynamic environments characterized by frequent close encounters. Accretion disks in active galactic nuclei (AGNs) are of particular interest, as certain observed features could be more readily produced within such environments. In this paper, we investigate the expected properties of mergers in these environments, and their dependence on various parameters, using 1D N-body simulations combined with a comprehensive semianalytical model. In our fiducial model, the distributions of masses (m1 and m2) and mass ratios (q ≡ m2/m1 ≤ 1) are similar to those observed. However, they depend strongly on the lifetime and density of the AGN disk and on the number and accretion efficiency of BHs, with higher masses predicted as these quantities increase. The most massive mergers, such as GW231123, can be produced either by efficient gas accretion or by hierarchical mergers among ≥3 generations of BHs. The observed negative correlation between q and the average effective spin (χeff), along with the positive correlation between χeff and the chirp mass (Mchirp), can be explained by a combination of efficient gas accretion, which promotes spin alignment, and hierarchical mergers, which produce high-∣χeff∣ and low-q binaries. Hierarchical mergers can also explain the negative correlation between q and the dispersion of χeff, as well as the positive correlation between ∣χeff∣and Mchirp. We present a comprehensive study on how the expected distribution of each of these quantities depends on model parameters and assumptions, which will aid the interpretation of observed GW population properties.","lang":"eng"}],"date_updated":"2026-08-18T09:05:25Z","external_id":{"arxiv":["2604.25994"]},"acknowledgement":"H.T. is supported by the National Science and Technology Major Project of China (No. 2024ZD1100601) and the National Key R&D Program of China (grant No.2024YFC2207700). Z.H. was supported by NASA grants 80NSSC22K0822 and 80NSSC24K0440. B.K. is supported by the Science and Technology Facilities Council grant No. ST/W000903/1. Simulations were carried out on Cray XD2000 at the Center for Computational Astrophysics, National Astronomical Observatory of Japan.","language":[{"iso":"eng"}],"date_published":"2026-08-10T00:00:00Z","department":[{"_id":"ZoHa"}],"doi":"10.3847/1538-4357/ae8760","OA_place":"publisher","article_processing_charge":"Yes","file":[{"relation":"main_file","date_updated":"2026-08-18T09:01:50Z","file_size":2246236,"file_id":"22731","content_type":"application/pdf","checksum":"1531fd5997b054d26e99d44ccc7f8ff5","access_level":"open_access","date_created":"2026-08-18T09:01:50Z","creator":"dernst","file_name":"2026_AstrophysicalJour_Tagawa.pdf","success":1}],"_id":"22713","author":[{"full_name":"Tagawa, Hiromichi","first_name":"Hiromichi","last_name":"Tagawa"},{"id":"7c006e8c-cc0d-11ee-8322-cb904ef76f36","orcid":"0000-0003-3633-5403","full_name":"Haiman, Zoltán","first_name":"Zoltán","last_name":"Haiman"},{"full_name":"Kocsis, Bence","first_name":"Bence","last_name":"Kocsis"}],"has_accepted_license":"1","publication":"The Astrophysical Journal","DOAJ_listed":"1","ddc":["520"],"publication_identifier":{"issn":["000-4637X"],"eissn":["1538-4357"]},"supplementarymaterial":"no","title":"Properties of black hole mergers in disks of active galactic nuclei","file_date_updated":"2026-08-18T09:01:50Z","type":"journal_article","issue":"1","publisher":"IOP Publishing","publication_status":"published","year":"2026","scopus_import":"1","day":"10","OA_type":"gold","citation":{"ieee":"H. Tagawa, Z. Haiman, and B. Kocsis, “Properties of black hole mergers in disks of active galactic nuclei,” <i>The Astrophysical Journal</i>, vol. 1007, no. 1. IOP Publishing, 2026.","ama":"Tagawa H, Haiman Z, Kocsis B. Properties of black hole mergers in disks of active galactic nuclei. <i>The Astrophysical Journal</i>. 2026;1007(1). doi:<a href=\"https://doi.org/10.3847/1538-4357/ae8760\">10.3847/1538-4357/ae8760</a>","short":"H. Tagawa, Z. Haiman, B. Kocsis, The Astrophysical Journal 1007 (2026).","apa":"Tagawa, H., Haiman, Z., &#38; Kocsis, B. (2026). Properties of black hole mergers in disks of active galactic nuclei. <i>The Astrophysical Journal</i>. IOP Publishing. <a href=\"https://doi.org/10.3847/1538-4357/ae8760\">https://doi.org/10.3847/1538-4357/ae8760</a>","ista":"Tagawa H, Haiman Z, Kocsis B. 2026. Properties of black hole mergers in disks of active galactic nuclei. The Astrophysical Journal. 1007(1), 67.","chicago":"Tagawa, Hiromichi, Zoltán Haiman, and Bence Kocsis. “Properties of Black Hole Mergers in Disks of Active Galactic Nuclei.” <i>The Astrophysical Journal</i>. IOP Publishing, 2026. <a href=\"https://doi.org/10.3847/1538-4357/ae8760\">https://doi.org/10.3847/1538-4357/ae8760</a>.","mla":"Tagawa, Hiromichi, et al. “Properties of Black Hole Mergers in Disks of Active Galactic Nuclei.” <i>The Astrophysical Journal</i>, vol. 1007, no. 1, 67, IOP Publishing, 2026, doi:<a href=\"https://doi.org/10.3847/1538-4357/ae8760\">10.3847/1538-4357/ae8760</a>."},"article_number":"67","volume":1007,"date_created":"2026-08-16T22:01:43Z","das_tickbox":"0"},{"dataavailabilitystatement":"Proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE64 partner repository with the dataset identifiers PXD062751 and PXD077567. RNA-seq data are available in the European Nucleotide Archive (ENA) under accession no. PRJEB93884, and ChIP–seq data at the Gene Expression Omnibus (GEO) under accession no. GSE302237. AlphaFold 3 interaction prediction parameters can be provided during the revision process on editorial and/or review request. Source data are provided with this paper.","external_id":{"pmid":["42562924"]},"abstract":[{"text":"Circadian clocks underlie daily rhythms in physiology by coordinating temporal patterns of gene expression and protein function throughout the body. At the core of this system in mammals is CLOCK/BMAL1, a ubiquitously expressed heterodimeric transcription factor complex that orchestrates tissue-specific circadian gene expression. The basis for this specificity remains unclear, but tissue-specific interactions at chromatin could provide one. Here we used chromatin immunoprecipitation coupled to mass spectrometry to map CLOCK/BMAL1-associated protein complexes on chromatin in mouse liver, kidney and lung. We detected 1,510 associated proteins, most of which were tissue-specific and not explained by protein abundance. Among these, we identified the homeodomain transcription factors PROX1, HNF1B and HOXA5 as tissue-enriched interactors that bind BMAL1, co-occupy most BMAL1 genomic sites and establish organ-restricted circadian transcription. Our findings demonstrate that tissue-specific transcription factors confer cellular identity on the core clock, thereby contributing to organ-specific patterns of rhythmic gene expression.","lang":"eng"}],"date_updated":"2026-08-18T08:03:22Z","month":"08","oa_version":"Published Version","quality_controlled":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"status":"public","researchdata_availability":"yes","PlanS_conform":"1","article_type":"original","pmid":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"ddc":["570"],"publication":"Nature Cell Biology","publication_identifier":{"eissn":["1476-4679"],"issn":["1465-7392"]},"supplementarymaterial":"yes","author":[{"full_name":"Aygenli, Fatih","last_name":"Aygenli","first_name":"Fatih"},{"last_name":"Huschet","first_name":"Lukas A.","full_name":"Huschet, Lukas A."},{"last_name":"Popp","first_name":"Tanja","full_name":"Popp, Tanja"},{"last_name":"Ribeiro","first_name":"Andrea","full_name":"Ribeiro, Andrea"},{"first_name":"Darina","last_name":"Barkhatova","orcid":"0000-0002-0062-2817","full_name":"Barkhatova, Darina","id":"db547c8c-329f-11ee-a353-cde802618f9e"},{"first_name":"Céline","last_name":"Jouffe","full_name":"Jouffe, Céline"},{"first_name":"Ricardo","last_name":"Trozzo","full_name":"Trozzo, Ricardo"},{"last_name":"Menet","first_name":"Jerome S.","full_name":"Menet, Jerome S."},{"first_name":"Roland","last_name":"Rad","full_name":"Rad, Roland"},{"first_name":"Kenneth A.","last_name":"Dyar","full_name":"Dyar, Kenneth A."},{"last_name":"Lech","first_name":"Maciej","full_name":"Lech, Maciej"},{"first_name":"Tobias","last_name":"Straub","full_name":"Straub, Tobias"},{"last_name":"Michael","first_name":"Alicia","full_name":"Michael, Alicia","orcid":"0000-0002-6080-839X","id":"6437c950-2a03-11ee-914d-d6476dd7b75c"},{"full_name":"Robles, Maria S.","last_name":"Robles","first_name":"Maria S."}],"has_accepted_license":"1","_id":"22720","OA_place":"publisher","article_processing_charge":"Yes (via OA deal)","project":[{"name":"Circadian structural transitions of chromatin","_id":"9136c684-16d5-11f0-9cad-91c0177b365f","grant_number":"101162145"}],"date_published":"2026-08-06T00:00:00Z","department":[{"_id":"GradSch"},{"_id":"AlMi"}],"doi":"10.1038/s41556-026-02041-4","language":[{"iso":"eng"}],"acknowledgement":"We thank all members of the Robles’ group for critical comments on and edits to this paper. We thank S. Kay for providing dihXY HCC cell lines and D. Firsov and Y. Bignon for mouse BMAL1-knockout (KO) kidney tissues. This work was supported by the German Research Foundation (DFG) project no. 213249687—SFB 1064 and RO 5675/1-1 to M.S.R., F.A. and L.A.H. M.S.R was also supported by DFG INST 86/1800-1 FUGG and LMU Munich’s Institutional Strategy LMU excellent within the framework of the German Excellence Initiative. J.S.M. was supported by US National Institutes of Health grant nos. R01GM145737 and R01DK128133. A.K.M. was supported by an ERC grant ‘ChromaChrono’ 101162145. Open access funding provided by Ludwig-Maximilians-Universität München.","year":"2026","publication_status":"epub_ahead","publisher":"Springer Nature","title":"CLOCK/BMAL1 interactome uncovers homeodomain factors as tissue regulators","type":"journal_article","das_tickbox":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41556-026-02041-4"}],"date_created":"2026-08-16T22:01:44Z","OA_type":"hybrid","citation":{"chicago":"Aygenli, Fatih, Lukas A. Huschet, Tanja Popp, Andrea Ribeiro, Darina Barkhatova, Céline Jouffe, Ricardo Trozzo, et al. “CLOCK/BMAL1 Interactome Uncovers Homeodomain Factors as Tissue Regulators.” <i>Nature Cell Biology</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41556-026-02041-4\">https://doi.org/10.1038/s41556-026-02041-4</a>.","mla":"Aygenli, Fatih, et al. “CLOCK/BMAL1 Interactome Uncovers Homeodomain Factors as Tissue Regulators.” <i>Nature Cell Biology</i>, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41556-026-02041-4\">10.1038/s41556-026-02041-4</a>.","ama":"Aygenli F, Huschet LA, Popp T, et al. CLOCK/BMAL1 interactome uncovers homeodomain factors as tissue regulators. <i>Nature Cell Biology</i>. 2026. doi:<a href=\"https://doi.org/10.1038/s41556-026-02041-4\">10.1038/s41556-026-02041-4</a>","short":"F. Aygenli, L.A. Huschet, T. Popp, A. Ribeiro, D. Barkhatova, C. Jouffe, R. Trozzo, J.S. Menet, R. Rad, K.A. Dyar, M. Lech, T. Straub, A.K. Michael, M.S. Robles, Nature Cell Biology (2026).","ista":"Aygenli F, Huschet LA, Popp T, Ribeiro A, Barkhatova D, Jouffe C, Trozzo R, Menet JS, Rad R, Dyar KA, Lech M, Straub T, Michael AK, Robles MS. 2026. CLOCK/BMAL1 interactome uncovers homeodomain factors as tissue regulators. Nature Cell Biology.","apa":"Aygenli, F., Huschet, L. A., Popp, T., Ribeiro, A., Barkhatova, D., Jouffe, C., … Robles, M. S. (2026). CLOCK/BMAL1 interactome uncovers homeodomain factors as tissue regulators. <i>Nature Cell Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41556-026-02041-4\">https://doi.org/10.1038/s41556-026-02041-4</a>","ieee":"F. Aygenli <i>et al.</i>, “CLOCK/BMAL1 interactome uncovers homeodomain factors as tissue regulators,” <i>Nature Cell Biology</i>. Springer Nature, 2026."},"day":"06","scopus_import":"1"},{"date_created":"2026-08-16T22:01:44Z","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2502.09550","open_access":"1"}],"citation":{"ieee":"P. A. Gazca-Orozco, F. Gmeineder, E. Maringová, and T. Tscherpel, “A Nitsche method for incompressible fluids with general dynamic boundary conditions,” <i>Mathematical Models and Methods in Applied Sciences</i>. World Scientific Publishing, 2026.","ista":"Gazca-Orozco PA, Gmeineder F, Maringová E, Tscherpel T. 2026. A Nitsche method for incompressible fluids with general dynamic boundary conditions. Mathematical Models and Methods in Applied Sciences.","apa":"Gazca-Orozco, P. A., Gmeineder, F., Maringová, E., &#38; Tscherpel, T. (2026). A Nitsche method for incompressible fluids with general dynamic boundary conditions. <i>Mathematical Models and Methods in Applied Sciences</i>. World Scientific Publishing. <a href=\"https://doi.org/10.1142/S0218202526500508\">https://doi.org/10.1142/S0218202526500508</a>","short":"P.A. Gazca-Orozco, F. Gmeineder, E. Maringová, T. Tscherpel, Mathematical Models and Methods in Applied Sciences (2026).","ama":"Gazca-Orozco PA, Gmeineder F, Maringová E, Tscherpel T. A Nitsche method for incompressible fluids with general dynamic boundary conditions. <i>Mathematical Models and Methods in Applied Sciences</i>. 2026. doi:<a href=\"https://doi.org/10.1142/S0218202526500508\">10.1142/S0218202526500508</a>","mla":"Gazca-Orozco, Pablo Alexei, et al. “A Nitsche Method for Incompressible Fluids with General Dynamic Boundary Conditions.” <i>Mathematical Models and Methods in Applied Sciences</i>, World Scientific Publishing, 2026, doi:<a href=\"https://doi.org/10.1142/S0218202526500508\">10.1142/S0218202526500508</a>.","chicago":"Gazca-Orozco, Pablo Alexei, Franz Gmeineder, Erika Maringová, and Tabea Tscherpel. “A Nitsche Method for Incompressible Fluids with General Dynamic Boundary Conditions.” <i>Mathematical Models and Methods in Applied Sciences</i>. World Scientific Publishing, 2026. <a href=\"https://doi.org/10.1142/S0218202526500508\">https://doi.org/10.1142/S0218202526500508</a>."},"OA_type":"green","day":"04","scopus_import":"1","year":"2026","publisher":"World Scientific Publishing","publication_status":"epub_ahead","mathsc":["65N30","76D07","76M10"],"type":"journal_article","title":"A Nitsche method for incompressible fluids with general dynamic boundary conditions","publication":"Mathematical Models and Methods in Applied Sciences","publication_identifier":{"issn":["0218-2025"],"eissn":["1793-6314"]},"_id":"22718","author":[{"full_name":"Gazca-Orozco, Pablo Alexei","last_name":"Gazca-Orozco","first_name":"Pablo Alexei"},{"full_name":"Gmeineder, Franz","last_name":"Gmeineder","first_name":"Franz"},{"last_name":"Maringová","first_name":"Erika","full_name":"Maringová, Erika","id":"dbabca31-66eb-11eb-963a-fb9c22c880b4"},{"full_name":"Tscherpel, Tabea","first_name":"Tabea","last_name":"Tscherpel"}],"article_processing_charge":"No","OA_place":"repository","language":[{"iso":"eng"}],"doi":"10.1142/S0218202526500508","department":[{"_id":"JuFi"}],"date_published":"2026-08-04T00:00:00Z","external_id":{"arxiv":["2502.09550"]},"month":"08","abstract":[{"text":"Both Newtonian and non-Newtonian fluids may exhibit complex slip behaviour at the boundary. We examine a broad class of slip boundary conditions that generalises the commonly used Navier slip, perfect slip, stick-slip and Tresca friction boundary conditions. In particular, set-valued, nonmonotone, noncoercive and dynamic relations may occur. For a unifying framework of such relations, we present a fully discrete numerical scheme for the time-dependent Navier–Stokes equations subject to impermeability and general slip-type boundary conditions on polyhedral domains. Based on compactness arguments, we prove convergence of subsequences, finally ensuring the existence of a weak solution. The numerical scheme uses a general inf-sup stable pair of finite element spaces for the velocity and pressure, a regularisation approach for the implicit slip boundary condition and, most importantly, a general Nitsche method to impose the impermeability and a backward Euler time stepping. One of the key tools in the convergence proof is an inhomogeneous Korn inequality that includes a normal trace term.","lang":"eng"}],"date_updated":"2026-08-18T07:51:59Z","arxiv":1,"quality_controlled":"1","oa_version":"Preprint","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","status":"public"},{"acknowledgement":"Open access funding provided by Institute of Science and Technology Austria. M.I. acknowledges financial support from ISTA and the Werner Siemens Foundation. The Scientific Service Units (SSU) of ISTA supported this work through resources provided by the Electron Microscopy Facility (EMF), the Lab Support Facility (LSF), the Nanofabrication Facility (NNF), and the Mass Spectrometry Facility. Y.L. acknowledges funding from the National Natural Science Foundation of China (NSFC) (grant no. 22209034) and the Fundamental Research Funds for the Central Universities (JZ2024HGTB0239). M.H. acknowledges funding from Australian Research Council (FT230100316), and the high-performance computing resources provided by National Computational Infrastructure (it39) and Pawsey Supercomputing Centre (pawsey1075). ICN2 acknowledges funding from Generalitat de Catalunya 2021SGR00457. The authors thank support from the project AMaDE (PID2023-149158OB-C43), funded by MCIN/AEI/10.13039/501100011033/ and by the “ERDF Away of making Europe”, by the “European Union”. ICN2 is supported by the Severo Ochoa program from Spanish MCIN/AEI (grant no.: CEX2021-001214-S) and is funded by the CERCA Programme/Generalitat de Catalunya. Authors acknowledge the use of instrumentation as well as the technical advice provided by the Joint Electron Microscopy Center at ALBA (JEMCA). ICN2 acknowledges funding from Grant IU16-014206 (METCAM-FIB) funded by the European Union through the European Regional Development Fund (ERDF), with the support of the Ministry of Research and Universities, Generalitat de Catalunya. ICN2 is founding member of e-DREAM. (91)","language":[{"iso":"eng"}],"department":[{"_id":"MassSpec"},{"_id":"MaIb"},{"_id":"GradSch"},{"_id":"EM-Fac"}],"date_published":"2026-08-14T00:00:00Z","doi":"10.1021/acsenergylett.6c01499","article_processing_charge":"Yes (via OA deal)","OA_place":"publisher","project":[{"_id":"9B8F7476-BA93-11EA-9121-9846C619BF3A","name":"HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery"}],"file":[{"success":1,"file_name":"2026_ACSEnergyLetters_Liu.pdf","checksum":"4d75c5a79d112c845c9eecba8838db38","file_id":"22736","content_type":"application/pdf","date_created":"2026-08-19T05:52:41Z","access_level":"open_access","creator":"dernst","file_size":6806815,"relation":"main_file","date_updated":"2026-08-19T05:52:41Z"}],"_id":"22734","author":[{"id":"2A70014E-F248-11E8-B48F-1D18A9856A87","full_name":"Liu, Yu","orcid":"0000-0001-7313-6740","first_name":"Yu","last_name":"Liu"},{"orcid":"0000-0003-1537-7436","full_name":"Kleinhanns, Tobias","last_name":"Kleinhanns","first_name":"Tobias","id":"8BD9DE16-AB3C-11E9-9C8C-2A03E6697425"},{"last_name":"Spadaro","first_name":"Maria Chiara","full_name":"Spadaro, Maria Chiara"},{"full_name":"Genç, Aziz","first_name":"Aziz","last_name":"Genç"},{"full_name":"Horta, Sharona","last_name":"Horta","first_name":"Sharona","id":"03a7e858-01b1-11ec-8b71-99ae6c4a05bc"},{"last_name":"Navita","first_name":"Navita","full_name":"Navita, Navita","orcid":"0000-0001-7408-8197","id":"6ebe278d-ba0b-11ee-8184-f34cdc671de4"},{"id":"D93824F4-D9BA-11E9-BB12-F207E6697425","full_name":"Costanzo, Tommaso","orcid":"0000-0001-9732-3815","last_name":"Costanzo","first_name":"Tommaso"},{"id":"0601cc46-c082-11ec-9b07-bb29641d1de9","full_name":"Dutkiewicz, Ewelina","last_name":"Dutkiewicz","first_name":"Ewelina"},{"full_name":"Arbiol, Jordi","first_name":"Jordi","last_name":"Arbiol"},{"full_name":"Hong, Min","last_name":"Hong","first_name":"Min"},{"id":"43C61214-F248-11E8-B48F-1D18A9856A87","first_name":"Maria","last_name":"Ibáñez","orcid":"0000-0001-5013-2843","full_name":"Ibáñez, Maria"}],"has_accepted_license":"1","publication":"ACS Energy Letters","ddc":["540"],"publication_identifier":{"eissn":["2380-8195"]},"acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"LifeSc"},{"_id":"NanoFab"},{"_id":"MassSpec"}],"supplementarymaterial":"yes","intvolume":"        11","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"researchdata_availability":"no","article_type":"letter_note","PlanS_conform":"1","oa_version":"Published Version","quality_controlled":"1","month":"08","date_updated":"2026-08-19T05:53:33Z","abstract":[{"text":"Silver selenide (Ag2Se) is a promising near-room-temperature thermoelectric material, but its narrow stoichiometric window and β–α phase transition complicate reproducible microstructure control. Here, we present a mismatch-assisted microstructure engineering strategy in which Ag2Se particles are treated with polyanionic ZnSe complexes and consolidated through the β–α transition to introduce ZnSe nanoprecipitates, Ag2Se/ZnSe interfaces, and local strain fields. The crystallographic mismatch between ZnSe and Ag2Se, together with the Zn2+/Ag+ size difference, amplifies phase-transition-induced deformation and promotes high-density dislocations with periodic strain modulations. This defect architecture suppresses grain coarsening, removes excess Ag, limits Ag-interstitial formation, and reduces lattice thermal conductivity through lattice softening and multiscale phonon scattering. Ag2Se–4%ZnSe nanocomposites achieve a peak zTmax of 1.13 at 369 K and a zTavg of 1.08 from 300 to 380 K, demonstrating mismatch-driven defect engineering through the β–α phase transition as a route for optimizing Ag2Se-based thermoelectrics.","lang":"eng"}],"scopus_import":"1","day":"14","OA_type":"hybrid","citation":{"short":"Y. Liu, T. Kleinhanns, M.C. Spadaro, A. Genç, S. Horta, N. Jakhar, T. Costanzo, E. Dutkiewicz, J. Arbiol, M. Hong, M. Ibáñez, ACS Energy Letters 11 (2026) 5752–5762.","ama":"Liu Y, Kleinhanns T, Spadaro MC, et al. Exploiting mismatch strain and the β–α phase transition for microstructural engineering in thermoelectric Ag2Se. <i>ACS Energy Letters</i>. 2026;11(8):5752-5762. doi:<a href=\"https://doi.org/10.1021/acsenergylett.6c01499\">10.1021/acsenergylett.6c01499</a>","ista":"Liu Y, Kleinhanns T, Spadaro MC, Genç A, Horta S, Jakhar N, Costanzo T, Dutkiewicz E, Arbiol J, Hong M, Ibáñez M. 2026. Exploiting mismatch strain and the β–α phase transition for microstructural engineering in thermoelectric Ag2Se. ACS Energy Letters. 11(8), 5752–5762.","apa":"Liu, Y., Kleinhanns, T., Spadaro, M. C., Genç, A., Horta, S., Jakhar, N., … Ibáñez, M. (2026). Exploiting mismatch strain and the β–α phase transition for microstructural engineering in thermoelectric Ag2Se. <i>ACS Energy Letters</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acsenergylett.6c01499\">https://doi.org/10.1021/acsenergylett.6c01499</a>","chicago":"Liu, Yu, Tobias Kleinhanns, Maria Chiara Spadaro, Aziz Genç, Sharona Horta, Navita Jakhar, Tommaso Costanzo, et al. “Exploiting Mismatch Strain and the β–α Phase Transition for Microstructural Engineering in Thermoelectric Ag2Se.” <i>ACS Energy Letters</i>. American Chemical Society, 2026. <a href=\"https://doi.org/10.1021/acsenergylett.6c01499\">https://doi.org/10.1021/acsenergylett.6c01499</a>.","mla":"Liu, Yu, et al. “Exploiting Mismatch Strain and the β–α Phase Transition for Microstructural Engineering in Thermoelectric Ag2Se.” <i>ACS Energy Letters</i>, vol. 11, no. 8, American Chemical Society, 2026, pp. 5752–62, doi:<a href=\"https://doi.org/10.1021/acsenergylett.6c01499\">10.1021/acsenergylett.6c01499</a>.","ieee":"Y. Liu <i>et al.</i>, “Exploiting mismatch strain and the β–α phase transition for microstructural engineering in thermoelectric Ag2Se,” <i>ACS Energy Letters</i>, vol. 11, no. 8. American Chemical Society, pp. 5752–5762, 2026."},"volume":11,"date_created":"2026-08-18T11:34:03Z","das_tickbox":"0","title":"Exploiting mismatch strain and the β–α phase transition for microstructural engineering in thermoelectric Ag2Se","file_date_updated":"2026-08-19T05:52:41Z","type":"journal_article","issue":"8","publisher":"American Chemical Society","publication_status":"published","year":"2026","page":"5752-5762","corr_author":"1"},{"day":"01","scopus_import":"1","das_tickbox":"1","date_created":"2026-08-16T22:01:43Z","volume":59,"OA_type":"hybrid","citation":{"chicago":"Hörmann, Anja F., Daniel Balazs, Ingo Breßler, Sumea Klokic, Melika Moradi, Eduardo Solano, Annika Stellhorn, and Brian R. Pauw. “Grazing-Incidence Scattering Surveyed: Towards Reference Methods for Alignment and Calibration.” <i>Journal of Applied Crystallography</i>. International Union of Crystallography, 2026. <a href=\"https://doi.org/10.1107/S1600576726005741\">https://doi.org/10.1107/S1600576726005741</a>.","mla":"Hörmann, Anja F., et al. “Grazing-Incidence Scattering Surveyed: Towards Reference Methods for Alignment and Calibration.” <i>Journal of Applied Crystallography</i>, vol. 59, no. 4, International Union of Crystallography, 2026, pp. 1247–53, doi:<a href=\"https://doi.org/10.1107/S1600576726005741\">10.1107/S1600576726005741</a>.","short":"A.F. Hörmann, D. Balazs, I. Breßler, S. Klokic, M. Moradi, E. Solano, A. Stellhorn, B.R. Pauw, Journal of Applied Crystallography 59 (2026) 1247–1253.","ama":"Hörmann AF, Balazs D, Breßler I, et al. Grazing-incidence scattering surveyed: Towards reference methods for alignment and calibration. <i>Journal of Applied Crystallography</i>. 2026;59(4):1247-1253. doi:<a href=\"https://doi.org/10.1107/S1600576726005741\">10.1107/S1600576726005741</a>","apa":"Hörmann, A. F., Balazs, D., Breßler, I., Klokic, S., Moradi, M., Solano, E., … Pauw, B. R. (2026). Grazing-incidence scattering surveyed: Towards reference methods for alignment and calibration. <i>Journal of Applied Crystallography</i>. International Union of Crystallography. <a href=\"https://doi.org/10.1107/S1600576726005741\">https://doi.org/10.1107/S1600576726005741</a>","ista":"Hörmann AF, Balazs D, Breßler I, Klokic S, Moradi M, Solano E, Stellhorn A, Pauw BR. 2026. Grazing-incidence scattering surveyed: Towards reference methods for alignment and calibration. Journal of Applied Crystallography. 59(4), 1247–1253.","ieee":"A. F. Hörmann <i>et al.</i>, “Grazing-incidence scattering surveyed: Towards reference methods for alignment and calibration,” <i>Journal of Applied Crystallography</i>, vol. 59, no. 4. International Union of Crystallography, pp. 1247–1253, 2026."},"issue":"4","keyword":["grazing incidence","reference methods","calibration","standardization","community"],"type":"journal_article","title":"Grazing-incidence scattering surveyed: Towards reference methods for alignment and calibration","file_date_updated":"2026-08-20T05:51:36Z","year":"2026","page":"1247-1253","publication_status":"published","publisher":"International Union of Crystallography","file":[{"success":1,"file_name":"2026_JourAppliedCrystallography_Hoermann.pdf","date_created":"2026-08-20T05:51:36Z","creator":"dernst","access_level":"open_access","file_id":"22739","content_type":"application/pdf","checksum":"8dbad0ab078338021e2cfe722211df7b","file_size":6692218,"relation":"main_file","date_updated":"2026-08-20T05:51:36Z"}],"OA_place":"publisher","article_processing_charge":"Yes (via OA deal)","doi":"10.1107/S1600576726005741","department":[{"_id":"LifeSc"}],"date_published":"2026-08-01T00:00:00Z","language":[{"iso":"eng"}],"acknowledgement":"The authors thank all respondents for their participation in the\r\nquestionnaire. We plan to make further use of the wealth of\r\nthe dataset going forward. We thank Xenocs for sharing\r\napproximate data on GISAXS equipment sales and Adrian\r\nRennie for helpful discussions. Open access funding enabled\r\nand organized by Projekt DEAL.","supplementarymaterial":"no","publication":"Journal of Applied Crystallography","ddc":["540"],"publication_identifier":{"eissn":["1600-5767"],"issn":["0021-8898"]},"has_accepted_license":"1","author":[{"first_name":"Anja F.","last_name":"Hörmann","full_name":"Hörmann, Anja F."},{"first_name":"Daniel","last_name":"Balazs","full_name":"Balazs, Daniel","orcid":"0000-0001-7597-043X","id":"302BADF6-85FC-11EA-9E3B-B9493DDC885E"},{"full_name":"Breßler, Ingo","first_name":"Ingo","last_name":"Breßler"},{"last_name":"Klokic","first_name":"Sumea","full_name":"Klokic, Sumea"},{"full_name":"Moradi, Melika","first_name":"Melika","last_name":"Moradi"},{"first_name":"Eduardo","last_name":"Solano","full_name":"Solano, Eduardo"},{"full_name":"Stellhorn, Annika","last_name":"Stellhorn","first_name":"Annika"},{"full_name":"Pauw, Brian R.","last_name":"Pauw","first_name":"Brian R."}],"_id":"22715","quality_controlled":"1","oa_version":"Published Version","article_type":"original","PlanS_conform":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"researchdata_availability":"yes","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"intvolume":"        59","dataavailabilitystatement":"The response data are available at https://doi.org/10.5281/\r\nzenodo.18712813. The literate programming source of this\r\nwork is available at https://doi.org/10.5281/zenodo.18713631.","date_updated":"2026-08-20T06:14:07Z","abstract":[{"lang":"eng","text":"Grazing-incidence small-angle scattering (GISAS) is a relatively young technique with important applications in thin-film technology and untapped potential when it comes to 2D analysis on an absolute intensity scale. Approaching standardization and reference methods early is foundational for reproducibility and comparability across laboratories and reduction of systematic error sources. It underpins trust in data obtained and accelerates innovation by ensuring that scientists work from a common methodological baseline. Accordingly, obtaining reproducible results from different GISAS instruments requires an agreement on how measurements are performed, instruments calibrated and terms defined. To pave the way for standardization and reference methods, we surveyed GISAS practitioners on what comes before an experiment: hardware, software, sample alignment and instrument calibration. Twenty-two questions were designed to elucidate the state of the art, which can be used for the development of reference methods. Our data on 27 instruments provide the basis for standardization. With very few exceptions, we found laboratories prepared to implement future reference methods, but no consensus emerges naturally for sample alignment and instrument calibration. We, that is the GISAS community, are thus in a position to embark on the journey of standardization."}],"month":"08"},{"OA_type":"gold","article_number":"31","citation":{"mla":"Goranci, Gramoz, et al. “Incremental Approximate Maximum Flow via Residual Graph Sparsification.” <i>ACM Transactions on Algorithms</i>, vol. 22, no. 3, 31, ACM, 2026, doi:<a href=\"https://doi.org/10.1145/3816252\">10.1145/3816252</a>.","chicago":"Goranci, Gramoz, Monika Henzinger, Harald Räcke, and A. R. Sricharan. “Incremental Approximate Maximum Flow via Residual Graph Sparsification.” <i>ACM Transactions on Algorithms</i>. ACM, 2026. <a href=\"https://doi.org/10.1145/3816252\">https://doi.org/10.1145/3816252</a>.","apa":"Goranci, G., Henzinger, M., Räcke, H., &#38; Sricharan, A. R. (2026). Incremental approximate maximum flow via residual graph sparsification. <i>ACM Transactions on Algorithms</i>. ACM. <a href=\"https://doi.org/10.1145/3816252\">https://doi.org/10.1145/3816252</a>","ista":"Goranci G, Henzinger M, Räcke H, Sricharan AR. 2026. Incremental approximate maximum flow via residual graph sparsification. ACM Transactions on Algorithms. 22(3), 31.","ama":"Goranci G, Henzinger M, Räcke H, Sricharan AR. Incremental approximate maximum flow via residual graph sparsification. <i>ACM Transactions on Algorithms</i>. 2026;22(3). doi:<a href=\"https://doi.org/10.1145/3816252\">10.1145/3816252</a>","short":"G. Goranci, M. Henzinger, H. Räcke, A.R. Sricharan, ACM Transactions on Algorithms 22 (2026).","ieee":"G. Goranci, M. Henzinger, H. Räcke, and A. R. Sricharan, “Incremental approximate maximum flow via residual graph sparsification,” <i>ACM Transactions on Algorithms</i>, vol. 22, no. 3. ACM, 2026."},"das_tickbox":"0","volume":22,"date_created":"2026-08-16T22:01:43Z","ec_funded":1,"scopus_import":"1","day":"06","publication_status":"published","publisher":"ACM","year":"2026","corr_author":"1","title":"Incremental approximate maximum flow via residual graph sparsification","file_date_updated":"2026-08-20T06:19:51Z","type":"journal_article","issue":"3","author":[{"first_name":"Gramoz","last_name":"Goranci","full_name":"Goranci, Gramoz"},{"full_name":"Henzinger, Monika H","orcid":"0000-0002-5008-6530","last_name":"Henzinger","first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630"},{"full_name":"Räcke, Harald","last_name":"Räcke","first_name":"Harald"},{"last_name":"Sricharan","first_name":"A. R.","full_name":"Sricharan, A. R."}],"has_accepted_license":"1","_id":"22716","publication_identifier":{"issn":["1549-6325"],"eissn":["1549-6333"]},"ddc":["000"],"publication":"ACM Transactions on Algorithms","supplementarymaterial":"yes","date_published":"2026-07-06T00:00:00Z","department":[{"_id":"MoHe"}],"doi":"10.1145/3816252","language":[{"iso":"eng"}],"acknowledgement":"M. Henzinger: This project has received funding from the European Research Council (ERC) under the European Union’s\r\nHorizon 2020 research and innovation programme (MoDynStruct, No. 101019564)   and the Austrian Science Fund\r\n(FWF) grant DOI 10.55776/Z422, grant DOI 10.55776/I5982, and grant DOI 10.55776/P33775 with additional funding from the\r\nnetidee SCIENCE Stiftung, 2020–2024. Views and opinions expressed are those of the author(s) only and do not necessarily\r\nreflect those of the European Union or the European Research Council Executive Agency. Neither the European Union nor\r\nthe granting authority can be held responsible for them","OA_place":"publisher","article_processing_charge":"Yes","file":[{"success":1,"file_name":"2026_TransactionsAlgorithms_Goranci.pdf","checksum":"97969d26dab25c3a35be3ae4dd0fd9ee","file_id":"22740","content_type":"application/pdf","creator":"dernst","date_created":"2026-08-20T06:19:51Z","access_level":"open_access","file_size":2272512,"date_updated":"2026-08-20T06:19:51Z","relation":"main_file"}],"project":[{"grant_number":"101019564","call_identifier":"H2020","name":"The design and evaluation of modern fully dynamic data structures","_id":"bd9ca328-d553-11ed-ba76-dc4f890cfe62"},{"name":"Efficient algorithms","_id":"34def286-11ca-11ed-8bc3-da5948e1613c","grant_number":"Z00422"},{"_id":"bda196b2-d553-11ed-ba76-8e8ee6c21103","name":"Static and Dynamic Hierarchical Graph Decompositions","grant_number":"I05982"},{"grant_number":"P33775","name":"Fast Algorithms for a Reactive Network Layer","_id":"bd9e3a2e-d553-11ed-ba76-8aa684ce17fe"}],"abstract":[{"text":"We give an algorithm that, with high probability, maintains a (1-ε)-approximate s-t maximum flow in undirected, uncapacitated n-vertex graphs undergoing m edge insertions in Õ(m+ n F^*/ε) total update time, where F^{*} is the maximum flow on the final graph. This is the first algorithm to achieve polylogarithmic amortized update time for dense graphs (m = Ω(n²)), and more generally, for graphs where F^* = Õ(m/n). At the heart of our incremental algorithm is the residual graph sparsification technique of Karger and Levine [SICOMP '15], originally designed for computing exact maximum flows in the static setting. Our main contributions are (i) showing how to maintain such sparsifiers for approximate maximum flows in the incremental setting and (ii) generalizing the cut sparsification framework of Fung et al. [SICOMP '19] from undirected graphs to balanced directed graphs.","lang":"eng"}],"date_updated":"2026-08-20T06:28:01Z","month":"07","external_id":{"arxiv":["2502.09105"]},"researchdata_availability":"no","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"status":"public","PlanS_conform":"1","article_type":"original","intvolume":"        22","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","related_material":{"record":[{"relation":"earlier_version","id":"21280","status":"public"}]},"oa":1,"oa_version":"Published Version","quality_controlled":"1","arxiv":1},{"file_date_updated":"2026-08-20T05:39:32Z","title":"Early fate diversification of radial glial progenitors during corticogenesis","type":"journal_article","issue":"32","publisher":"AAAS","publication_status":"published","year":"2026","page":"eadw5487","scopus_import":"1","day":"07","citation":{"mla":"Varela Martínez, Irene, et al. “Early Fate Diversification of Radial Glial Progenitors during Corticogenesis.” <i>Science Advances</i>, vol. 12, no. 32, AAAS, 2026, p. eadw5487, doi:<a href=\"https://doi.org/10.1126/sciadv.adw5487\">10.1126/sciadv.adw5487</a>.","chicago":"Varela Martínez, Irene, Ana Villalba Requena, Jorge García-Marqués, Alfonso Aguilera, Diogo S. Castro, Simon Hippenmeyer, and Marta Nieto. “Early Fate Diversification of Radial Glial Progenitors during Corticogenesis.” <i>Science Advances</i>. AAAS, 2026. <a href=\"https://doi.org/10.1126/sciadv.adw5487\">https://doi.org/10.1126/sciadv.adw5487</a>.","ista":"Varela Martínez I, Villalba Requena A, García-Marqués J, Aguilera A, Castro DS, Hippenmeyer S, Nieto M. 2026. Early fate diversification of radial glial progenitors during corticogenesis. Science Advances. 12(32), eadw5487.","apa":"Varela Martínez, I., Villalba Requena, A., García-Marqués, J., Aguilera, A., Castro, D. S., Hippenmeyer, S., &#38; Nieto, M. (2026). Early fate diversification of radial glial progenitors during corticogenesis. <i>Science Advances</i>. AAAS. <a href=\"https://doi.org/10.1126/sciadv.adw5487\">https://doi.org/10.1126/sciadv.adw5487</a>","ama":"Varela Martínez I, Villalba Requena A, García-Marqués J, et al. Early fate diversification of radial glial progenitors during corticogenesis. <i>Science Advances</i>. 2026;12(32):eadw5487. doi:<a href=\"https://doi.org/10.1126/sciadv.adw5487\">10.1126/sciadv.adw5487</a>","short":"I. Varela Martínez, A. Villalba Requena, J. García-Marqués, A. Aguilera, D.S. Castro, S. Hippenmeyer, M. Nieto, Science Advances 12 (2026) eadw5487.","ieee":"I. Varela Martínez <i>et al.</i>, “Early fate diversification of radial glial progenitors during corticogenesis,” <i>Science Advances</i>, vol. 12, no. 32. AAAS, p. eadw5487, 2026."},"OA_type":"gold","volume":12,"date_created":"2026-08-16T22:01:43Z","das_tickbox":"1","intvolume":"        12","pmid":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"status":"public","researchdata_availability":"yes","article_type":"original","PlanS_conform":"1","oa_version":"Published Version","quality_controlled":"1","month":"08","date_updated":"2026-08-20T05:45:28Z","abstract":[{"text":"Radial glial progenitors (RGPs) generate all projection neurons (PNs) in the cerebral cortex through incompletely understood processes. We combined Mosaic Analysis with Double Markers at embryonic stages (E)12.5 and E13.5 with early postnatal callosal tracing to dissect RGP lineage progression. We find that multipotent RGPs generate all extra-telencephalic (ET) and intra-telencephalic (IT) PNs via parallel sublineages that emerge simultaneously at neurogenesis onset. ET-PN production progresses exclusively via small, self-consuming lineages; IT-PN lineages feature RGPs generating large translaminar outputs. The early emergence of IT-PN–fated RGPs, coinciding with a switch to direct neurogenesis, contributes to the stereotyped population-level progression of the multipotent lineage. We also identify POU3F transcription factors as candidate regulators of IT-PN fate via noncanonical mitotic chromatin binding. The results support a model whereby IT- and ET-PNs arise from an early bifurcation and parallel specification within the multipotent RGP lineage.","lang":"eng"}],"external_id":{"pmid":["42555737"]},"dataavailabilitystatement":"All data and code needed to evaluate and reproduce the results in the paper are present in the paper and/or the Supplementary Materials. Source data underlying all figures (including the clonal atlas) are provided in the Supplementary Materials. RnA-seq analysis code has been deposited in Zenodo (dOi: 10.5281/zenodo.14609057). this study did not generate new materials.","language":[{"iso":"eng"}],"acknowledgement":"We thank M. caouyette for the plasmid construction for Pou3f1overexpression; d. Pinto-Benito for valuable assistance with shRnA validation in n2A cells andqPcR experiments; c. Varela-Martínez for help with the code for graphical analysis; allmembers from the nieto’s lab for comment on the manuscript, specially to F. Martín for theinsightful discussions; J. c. Oliveros and J. A. García from the computational service of the cnBfor help with the analysis of RnAseq dataset; c. O. Sorzano for help with statistical analysis; andA. Oña and the service of Advance Optical Microscopy of the cnB for technical advice.Funding: i.V.-M. holds a fellowship funded by MciciU (PRe-2018-083376) and 2023 eMBOscientific exchange grant 10214. the work was funded by grants to M.n. (Pid2020-112831GB- i00 and Pid2023-146322nB- i00 by Mcin/Aei/10.13039/501100011033 and by“eRdF A way of making europe”).","date_published":"2026-08-07T00:00:00Z","department":[{"_id":"SiHi"}],"doi":"10.1126/sciadv.adw5487","article_processing_charge":"Yes","OA_place":"publisher","file":[{"success":1,"file_name":"2026_ScienceAdv_VarelaMartinez.pdf","creator":"dernst","access_level":"open_access","date_created":"2026-08-20T05:39:32Z","file_id":"22738","checksum":"487c3703387080e8f3c4675d67763f0e","content_type":"application/pdf","date_updated":"2026-08-20T05:39:32Z","relation":"main_file","file_size":3056744}],"_id":"22714","author":[{"first_name":"Irene","last_name":"Varela Martínez","full_name":"Varela Martínez, Irene","id":"a69b5985-8829-11f0-8fc2-d0af58f64471"},{"orcid":"0000-0002-5615-5277","full_name":"Villalba Requena, Ana","last_name":"Villalba Requena","first_name":"Ana","id":"68cb85a0-39f7-11eb-9559-9aaab4f6a247"},{"full_name":"García-Marqués, Jorge","first_name":"Jorge","last_name":"García-Marqués"},{"full_name":"Aguilera, Alfonso","last_name":"Aguilera","first_name":"Alfonso"},{"full_name":"Castro, Diogo S.","first_name":"Diogo S.","last_name":"Castro"},{"id":"37B36620-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon","last_name":"Hippenmeyer","first_name":"Simon"},{"full_name":"Nieto, Marta","last_name":"Nieto","first_name":"Marta"}],"has_accepted_license":"1","DOAJ_listed":"1","publication_identifier":{"eissn":["2375-2548"]},"ddc":["570"],"publication":"Science Advances","supplementarymaterial":"yes"},{"year":"2026","publisher":"Springer Nature","publication_status":"published","type":"journal_article","title":"Single-cell analyses identify the ginseng embryonic protoderm as a native compartment for high-efficiency ginsenoside production","file_date_updated":"2026-08-20T06:44:33Z","date_created":"2026-08-16T22:01:42Z","volume":17,"das_tickbox":"1","OA_type":"gold","citation":{"ista":"Liu J, Zhai N, Zhang S, Tamada Y, Li T, Zhang L, Chen T, Wang C, Yang J, Gao J, Li X, Zhou J, Zhang Y, Liu Y, Wang Y, Friml J, Benková E, Li C, Xu L, Huang L. 2026. Single-cell analyses identify the ginseng embryonic protoderm as a native compartment for high-efficiency ginsenoside production. Nature Communications. 17, 7994.","apa":"Liu, J., Zhai, N., Zhang, S., Tamada, Y., Li, T., Zhang, L., … Huang, L. (2026). Single-cell analyses identify the ginseng embryonic protoderm as a native compartment for high-efficiency ginsenoside production. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-026-74881-5\">https://doi.org/10.1038/s41467-026-74881-5</a>","ama":"Liu J, Zhai N, Zhang S, et al. Single-cell analyses identify the ginseng embryonic protoderm as a native compartment for high-efficiency ginsenoside production. <i>Nature Communications</i>. 2026;17. doi:<a href=\"https://doi.org/10.1038/s41467-026-74881-5\">10.1038/s41467-026-74881-5</a>","short":"J. Liu, N. Zhai, S. Zhang, Y. Tamada, T. Li, L. Zhang, T. Chen, C. Wang, J. Yang, J. Gao, X. Li, J. Zhou, Y. Zhang, Y. Liu, Y. Wang, J. Friml, E. Benková, C. Li, L. Xu, L. Huang, Nature Communications 17 (2026).","mla":"Liu, Juan, et al. “Single-Cell Analyses Identify the Ginseng Embryonic Protoderm as a Native Compartment for High-Efficiency Ginsenoside Production.” <i>Nature Communications</i>, vol. 17, 7994, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41467-026-74881-5\">10.1038/s41467-026-74881-5</a>.","chicago":"Liu, Juan, Ning Zhai, Shiyi Zhang, Yosuke Tamada, Tonghui Li, Linfan Zhang, Tong Chen, et al. “Single-Cell Analyses Identify the Ginseng Embryonic Protoderm as a Native Compartment for High-Efficiency Ginsenoside Production.” <i>Nature Communications</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41467-026-74881-5\">https://doi.org/10.1038/s41467-026-74881-5</a>.","ieee":"J. Liu <i>et al.</i>, “Single-cell analyses identify the ginseng embryonic protoderm as a native compartment for high-efficiency ginsenoside production,” <i>Nature Communications</i>, vol. 17. Springer Nature, 2026."},"article_number":"7994","day":"07","scopus_import":"1","external_id":{"pmid":["42350386"]},"dataavailabilitystatement":"The RNA-seq data generated in this study have been deposited in the GSA database under accession code CRA008967. The scRNA-seq data generated in this study have been deposited in the GSA database under accession code CRA026200. The ATAC-seq data generated in this study have been deposited in the GSA database under accession code CRA008969. The ChIP-seq data generated in this study have been deposited in the GSA database under accession code CRA008968. Single-cell RNA-seq data and scripts are publicly available on Zenodo (https://zenodo.org/records/20392012). Primers are in Supplemental Table 5. Source data are provided with this paper.","month":"08","date_updated":"2026-08-20T06:45:46Z","abstract":[{"lang":"eng","text":"Ginseng (Panax ginseng) derives its renowned therapeutic properties from ginsenoside metabolites. However, the long cultivation cycle and susceptibility to diseases hinder the advancement of the ginseng industry. Here, we demonstrate that the embryonic protoderm of ginseng can efficiently produce ginsenosides. Single-cell transcriptome and mass spectrometry imaging analyses reveal that ginsenosides accumulate in the protoderm of ginseng embryonic callus (EC) at levels comparable to those in forest ginseng. Epigenetic analyses indicate that elevated histone acetylation and enhanced chromatin accessibility at regeneration- and ginsenoside metabolism-related gene loci are associated with the ginsenoside-producing capacity of EC. Increasing histone acetylation levels or overexpressing the regeneration-related WUSCHEL-RELATED HOMEOBOX11 (WOX11) gene further enhances ginsenoside production in EC. Our findings suggest that the protoderm of EC could serve as an in situ biological compartment for high-efficiency ginsenoside producion, offering a complementary approach to traditional ginseng cultivation."}],"quality_controlled":"1","oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"pmid":1,"intvolume":"        17","article_type":"original","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png"},"status":"public","researchdata_availability":"yes","supplementarymaterial":"yes","publication":"Nature Communications","DOAJ_listed":"1","publication_identifier":{"eissn":["2041-1723"]},"ddc":["580"],"_id":"22712","has_accepted_license":"1","author":[{"full_name":"Liu, Juan","first_name":"Juan","last_name":"Liu"},{"first_name":"Ning","last_name":"Zhai","full_name":"Zhai, Ning"},{"full_name":"Zhang, Shiyi","last_name":"Zhang","first_name":"Shiyi"},{"full_name":"Tamada, Yosuke","first_name":"Yosuke","last_name":"Tamada"},{"full_name":"Li, Tonghui","last_name":"Li","first_name":"Tonghui"},{"last_name":"Zhang","first_name":"Linfan","full_name":"Zhang, Linfan"},{"full_name":"Chen, Tong","last_name":"Chen","first_name":"Tong"},{"first_name":"Chenglin","last_name":"Wang","full_name":"Wang, Chenglin"},{"full_name":"Yang, Jian","first_name":"Jian","last_name":"Yang"},{"full_name":"Gao, Jiaqi","first_name":"Jiaqi","last_name":"Gao"},{"id":"4B7E523C-F248-11E8-B48F-1D18A9856A87","full_name":"Li, Xiang","last_name":"Li","first_name":"Xiang"},{"full_name":"Zhou, Junhui","last_name":"Zhou","first_name":"Junhui"},{"full_name":"Zhang, Yonghong","last_name":"Zhang","first_name":"Yonghong"},{"id":"2A70014E-F248-11E8-B48F-1D18A9856A87","first_name":"Yu","last_name":"Liu","full_name":"Liu, Yu","orcid":"0000-0001-7313-6740"},{"first_name":"Yuan","last_name":"Wang","full_name":"Wang, Yuan"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jiří","last_name":"Friml","orcid":"0000-0002-8302-7596","full_name":"Friml, Jiří"},{"id":"38F4F166-F248-11E8-B48F-1D18A9856A87","first_name":"Eva","last_name":"Benková","full_name":"Benková, Eva","orcid":"0000-0002-8510-9739"},{"full_name":"Li, Chen","last_name":"Li","first_name":"Chen"},{"first_name":"Lin","last_name":"Xu","full_name":"Xu, Lin"},{"full_name":"Huang, Luqi","last_name":"Huang","first_name":"Luqi"}],"file":[{"file_id":"22742","content_type":"application/pdf","checksum":"0b4ff29f0d0168b11be32a5f22ded9e4","creator":"dernst","date_created":"2026-08-20T06:44:33Z","access_level":"open_access","relation":"main_file","date_updated":"2026-08-20T06:44:33Z","file_size":2429551,"success":1,"file_name":"2026_NatureComm_Liu.pdf"}],"OA_place":"publisher","article_processing_charge":"Yes","acknowledgement":"The authors are grateful to Professor Linfeng Li from the School of Life Science, Fudan University, for his assistance during the ginseng genome annotation. This work was supported by Key project at central government level: The ability establishment of sustainable use for valuable Chinese medicine resources (2060302-2401-08 to L.X. and J.L.), the National Natural Science Foundation of China (82373987 to J.L., 31701294 to L.X., 32225007 to L.X., and 32300285 to N.Z.), the Fundamental Research Funds for the Central public welfare research institutes (ZZ13-YQ-093, ZZXT202508 to J.L.), the CACMS Innovation Fund (CI2025G00-06 to J.L.), the Principle Investigator Program (HBMUPI202104 to Y.Z.), the Key R&D Program of Shandong Province, China (2024LZGC025 to L.X.), the National Key R&D Program of China (2024YFF1000700/2023YFE0101100 to L.X.), Strategic Priority Research Program of Chinese Academy of Sciences (XDB0630000 to L.X.), and China Postdoctoral Science Foundation (2023M733490 to N.Z.).","language":[{"iso":"eng"}],"doi":"10.1038/s41467-026-74881-5","department":[{"_id":"JiFr"},{"_id":"EvBe"}],"date_published":"2026-08-07T00:00:00Z"},{"article_number":"7916","citation":{"ieee":"W. Shi, R. Korytár, F. Evers, J. D. Tovar, and L. Venkataraman, “Designing effective single-molecule electromagnets with radially π-conjugated carbon structures,” <i>Nature Communications</i>, vol. 17. Springer Nature, 2026.","ista":"Shi W, Korytár R, Evers F, Tovar JD, Venkataraman L. 2026. Designing effective single-molecule electromagnets with radially π-conjugated carbon structures. Nature Communications. 17, 7916.","apa":"Shi, W., Korytár, R., Evers, F., Tovar, J. D., &#38; Venkataraman, L. (2026). Designing effective single-molecule electromagnets with radially π-conjugated carbon structures. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-026-74365-6\">https://doi.org/10.1038/s41467-026-74365-6</a>","short":"W. Shi, R. Korytár, F. Evers, J.D. Tovar, L. Venkataraman, Nature Communications 17 (2026).","ama":"Shi W, Korytár R, Evers F, Tovar JD, Venkataraman L. Designing effective single-molecule electromagnets with radially π-conjugated carbon structures. <i>Nature Communications</i>. 2026;17. doi:<a href=\"https://doi.org/10.1038/s41467-026-74365-6\">10.1038/s41467-026-74365-6</a>","mla":"Shi, Wanzhuo, et al. “Designing Effective Single-Molecule Electromagnets with Radially π-Conjugated Carbon Structures.” <i>Nature Communications</i>, vol. 17, 7916, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41467-026-74365-6\">10.1038/s41467-026-74365-6</a>.","chicago":"Shi, Wanzhuo, Richard Korytár, Ferdinand Evers, John D. Tovar, and Latha Venkataraman. “Designing Effective Single-Molecule Electromagnets with Radially π-Conjugated Carbon Structures.” <i>Nature Communications</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41467-026-74365-6\">https://doi.org/10.1038/s41467-026-74365-6</a>."},"OA_type":"gold","volume":17,"date_created":"2026-08-16T22:01:42Z","das_tickbox":"1","scopus_import":"1","day":"06","publisher":"Springer Nature","publication_status":"published","year":"2026","corr_author":"1","file_date_updated":"2026-08-20T06:33:50Z","title":"Designing effective single-molecule electromagnets with radially π-conjugated carbon structures","type":"journal_article","_id":"22711","author":[{"id":"a3010425-87c8-11f0-8106-bec32bea74da","full_name":"Shi, Wanzhuo","first_name":"Wanzhuo","last_name":"Shi"},{"full_name":"Korytár, Richard","last_name":"Korytár","first_name":"Richard"},{"full_name":"Evers, Ferdinand","last_name":"Evers","first_name":"Ferdinand"},{"last_name":"Tovar","first_name":"John D.","full_name":"Tovar, John D."},{"id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf","full_name":"Venkataraman, Latha","orcid":"0000-0002-6957-6089","last_name":"Venkataraman","first_name":"Latha"}],"has_accepted_license":"1","ddc":["530"],"publication":"Nature Communications","DOAJ_listed":"1","publication_identifier":{"eissn":["2041-1723"]},"supplementarymaterial":"yes","acknowledgement":"The authors thank Jascha Repp from the University of Regensburg for helpful discussions. This paper is dedicated to the memory of Prof. Mark Ratner in appreciation of the encouragement offered many years ago, and whose influence had endured ever since. This work was supported by the National Science Foundation under grant NSF-DMR 2241180 and the Institute of Science and Technology Austria. The collaboration between L.V., R.K., and F.E. was supported by the Humboldt Foundation. This research was funded in part by the Austrian Science Fund (FWF) [10.55776/COE5] (Cluster of Excellence MECS).","language":[{"iso":"eng"}],"date_published":"2026-08-06T00:00:00Z","department":[{"_id":"LaVe"}],"doi":"10.1038/s41467-026-74365-6","OA_place":"publisher","article_processing_charge":"Yes","file":[{"file_name":"2026_NatureComm_Shi.pdf","success":1,"relation":"main_file","date_updated":"2026-08-20T06:33:50Z","file_size":1790013,"file_id":"22741","content_type":"application/pdf","checksum":"3f578b67037425a7c5d21922807b23df","date_created":"2026-08-20T06:33:50Z","creator":"dernst","access_level":"open_access"}],"month":"08","date_updated":"2026-08-20T06:40:49Z","abstract":[{"text":"When charge flows through a molecular circuit, it induces a magnetic field that allows the circuit to behave as a nanoscale electromagnet. However, in single-molecule circuits this magnetic field is usually weak. Here we show that radially π-conjugated carbon structures can support amplified circulating currents that generate local magnetic fields. Within tight-binding and density functional theory (DFT) frameworks, we first study cycloparaphenylene (CPP) junctions where both electrodes are attached to the same phenylene unit on the nanohoop. We observe an energy-dependent ring current component that traverses the whole macrocycle by mapping the local current density. Importantly, we find that destructive interference near degenerate resonances can reverse the ring current direction and amplify it strongly relative to the source–drain current. We show that this interference-driven design principle is general, and also carries over to C60 junctions. In fullerene, lower-lying degenerate resonances are more easily accessible through electrostatic gating, reaching a magnetic field of 14.2 mT under a 100 mV source–drain bias. This work thus provides new insights into ring currents in radially π-conjugated carbon structures and highlights their potential as design platforms for single-molecule electromagnets.","lang":"eng"}],"external_id":{"pmid":["42277037"]},"dataavailabilitystatement":"The data generated in this study have been deposited in the Code Ocean capsule. The capsule contains the FHI-aims and AITRANSS output matrices used for post-processing, precomputed cache files, and optimized atomic coordinate files. These data are sufficient to reproduce the results reported in the paper. The code used to reproduce the local-current and magnetic-field analyses is available in the Code Ocean capsule. The capsule includes Python scripts for post-processing DFT output matrices and Mathematica notebooks for tight-binding calculations and reproducing visualizations.","pmid":1,"intvolume":"        17","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png"},"researchdata_availability":"yes","status":"public","article_type":"original","oa_version":"Published Version","quality_controlled":"1"},{"file_date_updated":"2026-08-20T07:35:05Z","title":"Data and scripts for: \"Integrated solid/solution NMR assignment allows mapping dynamics and ligand binding in a 134 kDa enzyme\"","type":"research_data","publisher":"Institute of Science and Technology Austria","year":"2026","corr_author":"1","day":"20","citation":{"chicago":"Schanda, Paul, and Federico Napoli. “Data and Scripts for: ‘Integrated Solid/Solution NMR Assignment Allows Mapping Dynamics and Ligand Binding in a 134 KDa Enzyme.’” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-22687\">https://doi.org/10.15479/AT-ISTA-22687</a>.","mla":"Schanda, Paul, and Federico Napoli. <i>Data and Scripts for: “Integrated Solid/Solution NMR Assignment Allows Mapping Dynamics and Ligand Binding in a 134 KDa Enzyme.”</i> Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-22687\">10.15479/AT-ISTA-22687</a>.","ama":"Schanda P, Napoli F. Data and scripts for: “Integrated solid/solution NMR assignment allows mapping dynamics and ligand binding in a 134 kDa enzyme.” 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-22687\">10.15479/AT-ISTA-22687</a>","short":"P. Schanda, F. Napoli, (2026).","apa":"Schanda, P., &#38; Napoli, F. (2026). Data and scripts for: “Integrated solid/solution NMR assignment allows mapping dynamics and ligand binding in a 134 kDa enzyme.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-22687\">https://doi.org/10.15479/AT-ISTA-22687</a>","ista":"Schanda P, Napoli F. 2026. Data and scripts for: ‘Integrated solid/solution NMR assignment allows mapping dynamics and ligand binding in a 134 kDa enzyme’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-22687\">10.15479/AT-ISTA-22687</a>.","ieee":"P. Schanda and F. Napoli, “Data and scripts for: ‘Integrated solid/solution NMR assignment allows mapping dynamics and ligand binding in a 134 kDa enzyme.’” Institute of Science and Technology Austria, 2026."},"date_created":"2026-08-12T16:12:19Z","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","oa":1,"status":"public","tmp":{"image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"oa_version":"None","month":"08","abstract":[{"lang":"eng","text":"Understanding enzyme function requires characterizing not only static structure but also dynamics and ligand interactions. NMR spectroscopy provides this insight at atomic resolution, yet for large proteins the difficulty of resonance assignment has largely confined such studies to systems below ∼50 kDa, or to observing only methyl groups. Here we present an integrated magic-angle spinning (MAS) and solution NMR study of the 134 kDa tetrameric malate dehydrogenase from Ignicoccus islandicus (IiMDH), an enzyme of particular interest as an evolutionary intermediate between allosteric lactate\r\ndehydrogenases and non-allosteric malate dehydrogenases. By combining high-dimensional (up to 4D) MAS NMR experiments on sedimented protein with solution NMR, we achieved 92% backbone heavy- atom assignment and 91% assignment of all Ile-δ1, Leu-δ1/-δ2, Val-γ1/-γ2, Met-ε and Thr-γ methyl groups. Building on these assignments, we use various probes of backbone and sidechain dynamics: elevated MAS NMR 15N rotating-frame relaxation (R1ρ) points to microsecond motions in functionally critical regions, including the catalytic loop and the mobile surface loop. Complementary methyl-axis order parameters from solution NMR identified additional flexible sites in the hydrophobic core. Chemical shift perturbation experiments upon addition of the substrate analogue oxamate, monitored via backbone 1H-15N TROSY, revealed both active-site contacts and responses in helices α2F and α3G, regions implicated in allosteric signal transmission. The integrated approach demonstrated here exploits the distinct strengths of MAS and solution NMR, and provides a comprehensive view of structure, dynamics, and substrate interactions in a large oligomeric enzyme that would not be accessible by either technique alone."}],"date_updated":"2026-08-20T07:40:15Z","acknowledgement":"This research was supported by the Scientific Service Units (SSU) of Institute of Science and Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance and the Lab Support Facilities. We thank Petra Rovó, Megha Mohan and Margarita Valhondo Falcón for excellent support of the NMR facility.","date_published":"2026-08-20T00:00:00Z","department":[{"_id":"PaSc"}],"doi":"10.15479/AT-ISTA-22687","contributor":[{"orcid":"0000-0002-9043-136X","contributor_type":"researcher","last_name":"Napoli","first_name":"Federico","id":"d42e08e7-f4fc-11eb-af0a-d71e26138f1b"},{"id":"7B541462-FAF6-11E9-A490-E8DFE5697425","contributor_type":"project_leader","orcid":"0000-0002-9350-7606","first_name":"Paul","last_name":"Schanda"},{"id":"a3089acd-6806-11ee-bacc-f0c7d500ad20","last_name":"Singh","first_name":"Rajkumar","contributor_type":"project_member"},{"last_name":"Kapitonova","first_name":"Anna","contributor_type":"project_member","id":"9fb2a840-89e1-11ee-a8b7-cc5c7ba62471"},{"contributor_type":"project_member","first_name":"Virgil","last_name":"Aitenbichler"},{"id":"334a5e40-8747-11f0-b671-ba1f5154b4b4","contributor_type":"project_member","first_name":"Giorgia","last_name":"Toscano"},{"last_name":"Perrone","first_name":"Barbara","contributor_type":"data_collector"}],"article_processing_charge":"No","OA_place":"repository","file":[{"file_size":59096,"date_updated":"2026-08-18T07:13:26Z","relation":"main_file","file_id":"22725","checksum":"dd23db23f7e75bafad6c67381163c1e2","content_type":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","access_level":"open_access","creator":"fnapoli","date_created":"2026-08-18T07:13:26Z","file_name":"Pulse_parameters.xlsx","success":1},{"success":1,"file_name":"Scripts_submission.zip","creator":"fnapoli","date_created":"2026-08-18T07:16:00Z","access_level":"open_access","content_type":"application/zip","checksum":"a7ad194d8d7f780725bc2c60c63d686d","file_id":"22726","file_size":3591173,"date_updated":"2026-08-18T07:16:00Z","relation":"main_file"},{"checksum":"dc099c298844973512ab224464964a1a","file_id":"22727","content_type":"application/zip","creator":"fnapoli","date_created":"2026-08-18T07:15:59Z","access_level":"open_access","file_size":28750919,"relation":"main_file","date_updated":"2026-08-18T07:15:59Z","success":1,"file_name":"FLYA_runs.zip"},{"file_size":3824856998,"relation":"main_file","date_updated":"2026-08-18T07:33:47Z","checksum":"04bcce8eb20c90089cbd2fb5e0c50a7f","file_id":"22728","content_type":"application/zip","access_level":"open_access","date_created":"2026-08-18T07:33:47Z","creator":"fnapoli","file_name":"spectra_Bruker.zip","success":1},{"file_size":17880653,"date_updated":"2026-08-18T08:03:33Z","relation":"main_file","file_id":"22729","checksum":"91c1161ca98632ed643d2b564395da5b","content_type":"application/zip","date_created":"2026-08-18T08:03:33Z","creator":"fnapoli","access_level":"open_access","file_name":"Titration_data.zip","success":1},{"file_name":"README.txt","success":1,"file_size":868,"date_updated":"2026-08-20T07:35:05Z","relation":"main_file","creator":"arashid","access_level":"open_access","date_created":"2026-08-20T07:35:05Z","content_type":"text/plain","checksum":"ca2cf03b82656ae2858931d4391a3158","file_id":"22743"}],"project":[{"grant_number":"I05812","_id":"eb9c82eb-77a9-11ec-83b8-aadd536561cf","name":"AlloSpace. The emergence and mechanisms of allostery"}],"_id":"22687","doi_confirm":"1","author":[{"id":"7B541462-FAF6-11E9-A490-E8DFE5697425","first_name":"Paul","last_name":"Schanda","full_name":"Schanda, Paul","orcid":"0000-0002-9350-7606"},{"id":"d42e08e7-f4fc-11eb-af0a-d71e26138f1b","orcid":"0000-0002-9043-136X","full_name":"Napoli, Federico","first_name":"Federico","last_name":"Napoli"}],"has_accepted_license":"1","acknowledged_ssus":[{"_id":"NMR"},{"_id":"LifeSc"}]},{"scopus_import":"1","day":"28","OA_type":"gold","citation":{"ieee":"D. Vijatovic <i>et al.</i>, “Multifold increase in spinal inhibitory cell types with emergence of limb movement,” <i>Cell Reports</i>, vol. 45, no. 4. Elsevier, 2026.","chicago":"Vijatovic, David, Florina Alexandra  Toma, Y Ignatyev, Zoe P Harrington, Christoph M Sommer, Robert Hauschild, Matthijs Geert Smits, et al. “Multifold Increase in Spinal Inhibitory Cell Types with Emergence of Limb Movement.” <i>Cell Reports</i>. Elsevier, 2026. <a href=\"https://doi.org/10.1016/j.celrep.2026.117227\">https://doi.org/10.1016/j.celrep.2026.117227</a>.","mla":"Vijatovic, David, et al. “Multifold Increase in Spinal Inhibitory Cell Types with Emergence of Limb Movement.” <i>Cell Reports</i>, vol. 45, no. 4, 117227, Elsevier, 2026, doi:<a href=\"https://doi.org/10.1016/j.celrep.2026.117227\">10.1016/j.celrep.2026.117227</a>.","ama":"Vijatovic D, Toma FA, Ignatyev Y, et al. Multifold increase in spinal inhibitory cell types with emergence of limb movement. <i>Cell Reports</i>. 2026;45(4). doi:<a href=\"https://doi.org/10.1016/j.celrep.2026.117227\">10.1016/j.celrep.2026.117227</a>","short":"D. Vijatovic, F.A. Toma, Y. Ignatyev, Z.P. Harrington, C.M. Sommer, R. Hauschild, M.G. Smits, M. Dalla Vecchia, A.J. Trevisan, P. Chapman, M. Julseth, S. Brenner-Morton, M.I. Gabitto, J.S. Dasen, J.B. Bikoff, L.B. Sweeney, Cell Reports 45 (2026).","apa":"Vijatovic, D., Toma, F. A., Ignatyev, Y., Harrington, Z. P., Sommer, C. M., Hauschild, R., … Sweeney, L. B. (2026). Multifold increase in spinal inhibitory cell types with emergence of limb movement. <i>Cell Reports</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.celrep.2026.117227\">https://doi.org/10.1016/j.celrep.2026.117227</a>","ista":"Vijatovic D, Toma FA, Ignatyev Y, Harrington ZP, Sommer CM, Hauschild R, Smits MG, Dalla Vecchia M, Trevisan AJ, Chapman P, Julseth M, Brenner-Morton S, Gabitto MI, Dasen JS, Bikoff JB, Sweeney LB. 2026. Multifold increase in spinal inhibitory cell types with emergence of limb movement. Cell Reports. 45(4), 117227."},"article_number":"117227","volume":45,"date_created":"2026-04-19T22:07:43Z","file_date_updated":"2026-05-04T12:20:10Z","title":"Multifold increase in spinal inhibitory cell types with emergence of limb movement","type":"journal_article","issue":"4","publisher":"Elsevier","publication_status":"published","year":"2026","corr_author":"1","language":[{"iso":"eng"}],"acknowledgement":"We would like to thank the members of the Sweeney Lab, Mario de Bono, Michael Forsthofer, Katharina Lust, and Meital Oren, for comments on the manuscript. We are also grateful to Tom Jessell and Chris Kintner for their scientific insight and mentorship during the conception of this project. It would also have not been possible without the technical support of the Aquatics and Imaging and Optics Facility support teams (ISTA). We thank Martin Estermann for preparing the initial draft of the graphical abstract and Niki Barolini for the final version. In addition, we thank our funding sources for providing the resources to do these experiments: GFF NÖ FTI Strategy Lower Austria dissertation grant FT121-D-046 (to D.V.), Horizon Europe ERC starting grant 101041551 (to Y.I., L.B.S., F.A.T., and D.V.), Special Research Program (SFB) of the Austrian Science Fund (FWF) project F7814-B (to L.B.S.), Austrian Science Fund (FWF) 10.55776/COE16 (to Y.I. and L.B.S.), NINDS 5R35NS116858 (to J.S.D.), CZI grant DAF2020-225401 (DOI) 10.37921/120055ratwvi (to R.H.), NIH grant R01NS123116 (to J.B.B.), American Lebanese Syrian Associated Charities (ALSAC) (to J.B.B.), German Academic Exchange Service (DAAD) IFI grant 57515251-91853472 (to Z.H.), and Project A.L.S. (to S.B.-M.).","date_published":"2026-04-28T00:00:00Z","department":[{"_id":"LoSw"},{"_id":"GradSch"},{"_id":"TiVo"},{"_id":"Bio"},{"_id":"NiBa"}],"doi":"10.1016/j.celrep.2026.117227","article_processing_charge":"Yes","OA_place":"publisher","file":[{"file_name":"2026_CellReports_Vijatovic.pdf","success":1,"date_updated":"2026-05-04T12:20:10Z","relation":"main_file","file_size":14925958,"content_type":"application/pdf","checksum":"0d26cdb5b8d8dec3a911d8261a65cdef","file_id":"21795","creator":"dernst","access_level":"open_access","date_created":"2026-05-04T12:20:10Z"}],"project":[{"name":"Development and Evolution of Tetrapod Motor Circuits","_id":"ebb66355-77a9-11ec-83b8-b8ac210a4dae","grant_number":"101041551"},{"grant_number":"F7814","_id":"8da85f50-16d5-11f0-9cad-eab8b0ff6c9e","name":"Stem Cell Modulation in Neural Development and Regeneration/ P14-Swim-to-limb transition: cell type to connection diversity"},{"grant_number":"CZI01","name":"Tools for automation and feedback microscopy","_id":"c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473"},{"name":"Development of V1 interneuron diversity during swim-to-walk transition of Xenopus metamorphosis","_id":"bd73af52-d553-11ed-ba76-912049f0ac7a","grant_number":"FTI21-D-046"}],"_id":"21746","author":[{"first_name":"David","last_name":"Vijatovic","orcid":"0000-0002-5494-0941","full_name":"Vijatovic, David","id":"cf391e77-ec3c-11ea-a124-d69323410b58"},{"first_name":"Florina Alexandra ","last_name":"Toma","full_name":"Toma, Florina Alexandra ","id":"2f73f876-f128-11eb-9611-b96b5a30cb0e"},{"last_name":"Ignatyev","first_name":"Y","full_name":"Ignatyev, Y"},{"id":"a8144562-32c9-11ee-b5ce-d9800628bda2","orcid":"0009-0008-0158-4032","full_name":"Harrington, Zoe P","first_name":"Zoe P","last_name":"Harrington"},{"id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","first_name":"Christoph M","last_name":"Sommer","orcid":"0000-0003-1216-9105","full_name":"Sommer, Christoph M"},{"last_name":"Hauschild","first_name":"Robert","orcid":"0000-0001-9843-3522","full_name":"Hauschild, Robert","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87"},{"id":"7a231d52-e216-11ee-a0bb-8acd55f8f1f0","full_name":"Smits, Matthijs Geert","first_name":"Matthijs Geert","last_name":"Smits"},{"full_name":"Dalla Vecchia, Marco","first_name":"Marco","last_name":"Dalla Vecchia","id":"02a7a869-ff06-11ed-a87f-86649d6077e5"},{"last_name":"Trevisan","first_name":"Alexandra J.","full_name":"Trevisan, Alexandra J."},{"full_name":"Chapman, Phillip","first_name":"Phillip","last_name":"Chapman"},{"full_name":"Julseth, Mara","first_name":"Mara","last_name":"Julseth","id":"1cf464b2-dc7d-11ea-9b2f-f9b1aa9417d1"},{"first_name":"Susan","last_name":"Brenner-Morton","full_name":"Brenner-Morton, Susan"},{"full_name":"Gabitto, Mariano I.","last_name":"Gabitto","first_name":"Mariano I."},{"full_name":"Dasen, Jeremy S.","last_name":"Dasen","first_name":"Jeremy S."},{"first_name":"Jay B.","last_name":"Bikoff","full_name":"Bikoff, Jay B."},{"orcid":"0000-0001-9242-5601","full_name":"Sweeney, Lora Beatrice Jaeger","last_name":"Sweeney","first_name":"Lora Beatrice Jaeger","id":"56BE8254-C4F0-11E9-8E45-0B23E6697425"}],"has_accepted_license":"1","DOAJ_listed":"1","ddc":["570"],"publication_identifier":{"eissn":["2211-1247"],"issn":["2639-1856"]},"publication":"Cell Reports","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"intvolume":"        45","pmid":1,"oa":1,"related_material":{"record":[{"relation":"dissertation_contains","id":"22667","status":"public"}]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"status":"public","article_type":"original","PlanS_conform":"1","oa_version":"Published Version","quality_controlled":"1","month":"04","abstract":[{"text":"As vertebrates transitioned from water to land, locomotion shifted from undulatory swimming to limb-based movement. How spinal circuits and their cell types evolved to support this transition remains unclear. We leverage frog metamorphosis, which recapitulates this transition within a single organism, to define how spinal circuits generate aquatic versus terrestrial motor patterns. At swim stages, spinal architecture is uniform, with a transcriptionally and anatomically homogeneous motor and interneurons. As limbs develop and their movement complexifies, spinal circuits expand in neuron number and subtype diversity. This expansion is most pronounced for V1 inhibitory neurons, which increase ∼70-fold and diversify into transcriptionally distinct subtypes. Disrupting transcription factors defining emerging motor and V1 populations reveals molecular segregation between swim and limb circuits, highlighting the role of subtype diversity in motor coordination. A multifold increase in inhibitory neuron diversity thus underlies the tail-to-limb locomotor transition, providing a framework for spinal circuit adaptation during vertebrate evolution.","lang":"eng"}],"date_updated":"2026-08-20T14:45:18Z","external_id":{"pmid":["41964955 "]}},{"citation":{"mla":"Vijatovic, David. <i>Dissecting the Molecular and Functional Basis of Motor Control in the Frog Xenopus Laevis</i>. Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-22667\">10.15479/AT-ISTA-22667</a>.","chicago":"Vijatovic, David. “Dissecting the Molecular and Functional Basis of Motor Control in the Frog Xenopus Laevis.” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-22667\">https://doi.org/10.15479/AT-ISTA-22667</a>.","apa":"Vijatovic, D. (2026). <i>Dissecting the molecular and functional basis of motor control in the frog Xenopus laevis</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-22667\">https://doi.org/10.15479/AT-ISTA-22667</a>","ista":"Vijatovic D. 2026. Dissecting the molecular and functional basis of motor control in the frog Xenopus laevis. Institute of Science and Technology Austria.","short":"D. Vijatovic, Dissecting the Molecular and Functional Basis of Motor Control in the Frog Xenopus Laevis, Institute of Science and Technology Austria, 2026.","ama":"Vijatovic D. Dissecting the molecular and functional basis of motor control in the frog Xenopus laevis. 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-22667\">10.15479/AT-ISTA-22667</a>","ieee":"D. Vijatovic, “Dissecting the molecular and functional basis of motor control in the frog Xenopus laevis,” Institute of Science and Technology Austria, 2026."},"date_created":"2026-08-10T13:44:30Z","day":"10","publisher":"Institute of Science and Technology Austria","publication_status":"published","corr_author":"1","year":"2026","page":"172","type":"dissertation","file_date_updated":"2026-08-12T13:44:36Z","title":"Dissecting the molecular and functional basis of motor control in the frog Xenopus laevis","supervisor":[{"full_name":"Sweeney, Lora Beatrice Jaeger","orcid":"0000-0001-9242-5601","first_name":"Lora Beatrice Jaeger","last_name":"Sweeney","id":"56BE8254-C4F0-11E9-8E45-0B23E6697425"}],"_id":"22667","alternative_title":["ISTA Thesis"],"has_accepted_license":"1","doi_confirm":"1","author":[{"last_name":"Vijatovic","first_name":"David","full_name":"Vijatovic, David","orcid":"0000-0002-5494-0941","id":"cf391e77-ec3c-11ea-a124-d69323410b58"}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-082-4"]},"ddc":["573"],"acknowledgement":"I am also grateful for the financial support that made this work possible, including the\r\nEuropean Research Council (ERC Starting Grant 101041551), the Austrian Science\r\nFund (FWF, Cluster of Excellence 10.55776/COE16), the GFF Lower Austria FTI\r\nStrategy Dissertation Fellowship (FTI21-D-046), and the FENS/IBRO-PERC\r\nExchange Fellowship. 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