[{"researchdata_availability":"no","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"file":[{"date_created":"2026-10-12T06:20:29Z","file_id":"23097","content_type":"application/pdf","creator":"dernst","checksum":"055c80a2cd071884e2804ef17dcf1e16","file_size":14151909,"file_name":"2026_AstronomyAstrophysics_Yang.pdf","access_level":"open_access","relation":"main_file","date_updated":"2026-10-12T06:20:29Z","success":1}],"doi":"10.1051/0004-6361/202658883","oa":1,"das_tickbox":"1","external_id":{"arxiv":["2607.03432"]},"article_type":"original","article_processing_charge":"No","volume":711,"has_accepted_license":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"23044","title":"Euclid: Discovery of 31 new quasars at 6.6 < z < 7.8","day":"01","publication_identifier":{"eissn":["1432-0746"],"issn":["0004-6361"]},"arxiv":1,"department":[{"_id":"JoMa"}],"fulldoi":"https://doi.org/10.1051/0004-6361/202658883","supplementarymaterial":"yes","publication_status":"published","publication":"Astronomy & Astrophysics","year":"2026","date_created":"2026-10-04T22:01:54Z","intvolume":" 711","article_number":"A104","acknowledgement":"D. Yang acknowledges helpful discussions with members of the ENIGMA group at UC Santa Barbara and Leiden University, in particular Elia Pizzati, Silvia Onorato, and Diego González for their valuable feedback. D. Yang thanks Shane Bechtel for assistance during observations, and acknowledges the early contributions of Riccardo Nanni, which helped lay the foundation for this work. D. Yang and J. F. Hennawi acknowledge support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No 885301). J. F. Hennawi acknowledges support from NSF grant No. 2307180. F. Guarneri and J.-T. Schindler are supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Project number 518006966. F. Wang acknowledges support from NSF award AST-2513040. R. Decarli acknowledges support from the INAF GO 2022 grant “The birth of the giants: JWST sheds light on the build-up of quasars at cosmic dawn”, INAF Minigrant 2024 “The interstellar medium at high redshift”, and by the PRIN MUR “2022935STW”, RFF M4.C2.1.1, CUP J53D23001570006 and C53D23000950006. S. E. I. Bosman is supported by the Deutsche Forschungsgemeinschaft (DFG) under Emmy Noether grant number BO 5771/1-1. Y. Harikane acknowledges support from the Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research (24H00245), the JSPS Core-to-Core Program (JPJSCCA20210003), and the JSPS International Leading Research (22K21349). J. R. Weaver acknowledges that support for this work was provided by The Brinson Foundation through a Brinson Prize Fellowship grant. The Euclid Consortium acknowledges the European Space Agency and a number of agencies and institutes that have supported the development of Euclid, in particular the Agenzia Spaziale Italiana, the Austrian Forschungsförderungsgesellschaft funded through BMIMI, the Belgian Science Policy, the Canadian Euclid Consortium, the Deutsches Zentrum für Luft- und Raumfahrt, the DTU Space and the Niels Bohr Institute in Denmark, the French Centre National d’Etudes Spatiales, the Fundação para a Ciência e a Tecnologia, the Hungarian Academy of Sciences, the Ministerio de Ciencia, Innovación y Universidades, the National Aeronautics and Space Administration, the National Astronomical Observatory of Japan, the Netherlandse Onderzoekschool Voor Astronomie, the Norwegian Space Agency, the Research Council of Finland, the Romanian Space Agency, the State Secretariat for Education, Research, and Innovation (SERI) at the Swiss Space Office (SSO), and the United Kingdom Space Agency. A complete and detailed list is available on the Euclid web site (www.euclid-ec.org). Some of the data presented herein were obtained at Keck Observatory, which is a private 501(c)3 non-profit organization operated as a scientific partnership among the California Institute of Technology, the University of California, and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W. M. Keck Foundation. The authors wish to recognise and acknowledge the very significant cultural role and reverence that the summit of Maunakea has always had within the Native Hawaiian community. We are most fortunate to have the opportunity to conduct observations from this mountain. This paper includes data gathered with the 6.5 meter Magellan Telescopes located at Las Campanas Observatory, Chile. This work uses LBT data from programmes: MPIA-2025A-007 and MPIA-2025B-004. The LBT is an international collaboration among institutions in the United States, Italy and Germany. LBT Corporation partners are: The University of Arizona on behalf of the Arizona university system; Istituto Nazionale di Astrofisica, Italy; LBT Beteiligungsgesellschaft, Germany, representing the Max-Planck Society, the Astrophysical Institute Potsdam, and Heidelberg University; The Ohio State University, and The Research Corporation, on behalf of The University of Notre Dame, University of Minnesota, and University of Virginia, LOFAR data products were provided by the LOFAR Surveys Key Science project (LSKSP; https://lofar-surveys.org/) and were derived from observations with the International LOFAR Telescope (ILT). LOFAR is the Low Frequency Array designed and constructed by ASTRON. It has observing, data processing, and data storage facilities in several countries, which are owned by various parties (each with their own funding sources), and which are collectively operated by the ILT foundation under a joint scientific policy. The efforts of the LSKSP have benefited from funding from the European Research Council, NOVA, NWO, CNRS-INSU, the SURF Co-operative, the UK Science and Technology Funding Council and the Jülich Supercomputing Centre. We make use of z-band imaging from the Wide Imaging with Subaru HSC of the Euclid Sky (WISHES) program operated by the Subaru Telescope, which is operated by the National Astronomical Observatory of Japan. We also make use of z-band imaging from the Dark Energy Survey (DES), based on observations obtained at the Cerro Tololo Inter-American Observatory, National Optical Astronomy Observatory, which is operated by AURA under a cooperative agreement with the National Science Foundation. This work made use of NumPy (Harris et al. 2020), SciPy (Virtanen et al. 2020), Astropy (Astropy Collaboration 2013, 2018, 2022), PypeIt (Prochaska et al. 2020), Sculptor (Schindler 2022), condXD (Kang et al. 2025), pysersic (Pasha & Miller 2023), Matplotlib (Hunter 2007), corner.py (Foreman-Mackey 2016), healpy (Zonca et al. 2020).","file_date_updated":"2026-10-12T06:20:29Z","publisher":"EDP Sciences","ddc":["520"],"month":"07","date_published":"2026-07-01T00:00:00Z","citation":{"ama":"Yang D, Hennawi JF, Guarneri F, et al. Euclid: Discovery of 31 new quasars at 6.6 < z < 7.8. Astronomy & Astrophysics. 2026;711. doi:10.1051/0004-6361/202658883","ista":"Yang D et al. 2026. Euclid: Discovery of 31 new quasars at 6.6 < z < 7.8. Astronomy & Astrophysics. 711, A104.","ieee":"D. Yang et al., “Euclid: Discovery of 31 new quasars at 6.6 < z < 7.8,” Astronomy & Astrophysics, vol. 711. EDP Sciences, 2026.","short":"D. Yang, J.F. Hennawi, F. Guarneri, J. Wolf, S. Belladitta, J.T. Schindler, A.C.N. Hughes, E. Bañados, D.J. Mortlock, J. Yang, F. Wang, X. Fan, K. Jahnke, D. Stern, C.J. Willott, A.J. Barth, H.J.A. Rottgering, R.G. Varadaraj, R. Decarli, A.C. Eilers, M. Ezziati, Y. Fu, J. Huang, X. Jin, Y. Kang, L.N. Martinez-Ramirez, Y. Matsuoka, M. Onoue, R. Pello, R.P. Remigio, W.L. Tee, B. Venemans, G. Vietri, B. Wang, L.J. Abbo, H. Atek, S. Bisogni, S.E.I. Bosman, R.A.A. Bowler, C.J. Conselice, F.B. Davies, C.M. Gutierrez, Y. Harikane, K. Rubinur, C.C. Lovell, M. Magliocchetti, J.J. Matthee, F. Ricci, M. Scialpi, D. Scott, L. Spinoglio, F. Tarsitano, Y. Toba, F. Walter, J.R. Weaver, G. Zamorani, B. Altieri, A. Amara, S. Andreon, H. Aussel, C. Baccigalupi, M. Baldi, A. Balestra, S. Bardelli, P. Battaglia, A. Biviano, E. Branchini, M. Brescia, S. Camera, G. Cañas-Herrera, V. Capobianco, C. Carbone, J. Carretero, M. Castellano, G. Castignani, S. Cavuoti, K.C. Chambers, A. Cimatti, C. Colodro-Conde, G. Congedo, L. Conversi, Y. Copin, F. Courbin, H.M. Courtois, M. Cropper, J.C. Cuillandre, H. Degaudenzi, G. De Lucia, C. Dolding, H. Dole, M. Douspis, F. Dubath, X. Dupac, S. Dusini, S. Escoffier, M. Farina, R. Farinelli, S. Ferriol, F. Finelli, N. Fourmanoit, M. Frailis, E. Franceschi, M. Fumana, S. Galeotta, K. George, B. Gillis, C. Giocoli, P. Gómez-Alvarez, J. Gracia-Carpio, A. Grazian, F. Grupp, L. Guzzo, S. Gwyn, S.V.H. Haugan, H. Hoekstra, W. Holmes, I.M. Hook, F. Hormuth, A. Hornstrup, M. Jhabvala, S. Kermiche, B. Kubik, K. Kuijken, M. Kümmel, M. Kunz, H. Kurki-Suonio, A.M.C. Le Brun, S. Ligori, P.B. Lilje, V. Lindholm, I. Lloro, G. Mainetti, D. Maino, E. Maiorano, O. Mansutti, O. Marggraf, M. Martinelli, N. Martinet, F. Marulli, R.J. Massey, H.J. Mccracken, E. Medinaceli, S. Mei, Y. Mellier, M. Meneghetti, E. Merlin, G. Meylan, J.J. Mohr, A. Mora, M. Moresco, L. Moscardini, E. Munari, R. Nakajima, C. Neissner, R.C. Nichol, S.M. Niemi, C. Padilla, S. Paltani, F. Pasian, K. Pedersen, W.J. Percival, V. Pettorino, S. Pires, G. Polenta, M. Poncet, L.A. Popa, L. Pozzetti, G.D. Racca, F. Raison, R. Rebolo, A. Renzi, J. Rhodes, G. Riccio, H.W. Rix, E. Romelli, M. Roncarelli, C. Rosset, B. Rusholme, R. Saglia, Z. Sakr, D. Sapone, M. Sauvage, M. Schirmer, P. Schneider, T. Schrabback, A. Secroun, G. Seidel, S. Serrano, E. Sihvola, P. Simon, C. Sirignano, G. Sirri, L. Stanco, J. Steinwagner, P. Tallada-Crespí, I. Tereno, N. Tessore, S. Toft, R. Toledo-Moreo, F. Torradeflot, I. Tutusaus, L. Valenziano, J. Valiviita, T. Vassallo, Y. Wang, J. Weller, F.M. Zerbi, E. Zucca, G. Fabbian, M. Huertas-Company, J. Martín-Fleitas, P. Monaco, V. Scottez, M. Viel, Astronomy & Astrophysics 711 (2026).","apa":"Yang, D., Hennawi, J. F., Guarneri, F., Wolf, J., Belladitta, S., Schindler, J. T., … Viel, M. (2026). Euclid: Discovery of 31 new quasars at 6.6 < z < 7.8. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202658883","mla":"Yang, D., et al. “Euclid: Discovery of 31 New Quasars at 6.6 < z < 7.8.” Astronomy & Astrophysics, vol. 711, A104, EDP Sciences, 2026, doi:10.1051/0004-6361/202658883.","chicago":"Yang, D., J. F. Hennawi, F. Guarneri, J. Wolf, S. Belladitta, J. T. Schindler, A. C.N. Hughes, et al. “Euclid: Discovery of 31 New Quasars at 6.6 < z < 7.8.” Astronomy & Astrophysics. EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202658883."},"oa_version":"Published Version","quality_controlled":"1","status":"public","PlanS_conform":"1","OA_place":"publisher","type":"journal_article","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"We report the discovery of 31 new high-z quasars in the redshift range 6.6 < z < 7.8. These quasars were selected from approximately 3000 deg2 of sky covered during the first 1.5 years of the Euclid Wide Survey, representing the initial results of the Euclid high-z quasar search. Our candidate selection employed multiple machine-learning and probabilistic techniques applied to the EuclidIE, YE, JE, and HE images, supplemented by ancillary z-band data when available. Spectroscopic follow-up observations were carried out with Keck, Magellan, and the Large Binocular Telescope (LBT). Among the new discoveries, there are 12 quasars at z ≥ 7, more than doubling the number of previously known quasars at z ≥ 7. The newly discovered quasars exhibit 21.2 < JE < 23.2 (−25.5 < M1450 < −23.6), extending quasar studies to the faint end of the quasar luminosity function (QLF) at z ≳ 7. The quasar with the highest-z, EUCL J172902.75+641018.1 at z ≈ 7.77, sets the new redshift record for the most distant quasar ever reported. These discoveries demonstrate Euclid’s transformative role in high-z quasar discovery and set the stage for future follow-up studies of the early galaxies hosting quasars, supermassive black hole growth, and the intergalactic medium in the epoch of reionisation."}],"author":[{"full_name":"Yang, D.","last_name":"Yang","first_name":"D."},{"full_name":"Hennawi, J. F.","last_name":"Hennawi","first_name":"J. F."},{"full_name":"Guarneri, F.","last_name":"Guarneri","first_name":"F."},{"first_name":"J.","last_name":"Wolf","full_name":"Wolf, J."},{"full_name":"Belladitta, S.","first_name":"S.","last_name":"Belladitta"},{"last_name":"Schindler","first_name":"J. T.","full_name":"Schindler, J. T."},{"full_name":"Hughes, A. C.N.","last_name":"Hughes","first_name":"A. C.N."},{"full_name":"Bañados, E.","last_name":"Bañados","first_name":"E."},{"full_name":"Mortlock, D. J.","first_name":"D. J.","last_name":"Mortlock"},{"last_name":"Yang","first_name":"J.","full_name":"Yang, J."},{"full_name":"Wang, F.","last_name":"Wang","first_name":"F."},{"full_name":"Fan, X.","first_name":"X.","last_name":"Fan"},{"first_name":"K.","last_name":"Jahnke","full_name":"Jahnke, K."},{"full_name":"Stern, D.","first_name":"D.","last_name":"Stern"},{"first_name":"C. J.","last_name":"Willott","full_name":"Willott, C. J."},{"first_name":"A. J.","last_name":"Barth","full_name":"Barth, A. J."},{"full_name":"Rottgering, H. J.A.","first_name":"H. J.A.","last_name":"Rottgering"},{"first_name":"R. G.","last_name":"Varadaraj","full_name":"Varadaraj, R. G."},{"full_name":"Decarli, R.","last_name":"Decarli","first_name":"R."},{"full_name":"Eilers, A. C.","first_name":"A. 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The discovery spectra are available from the corresponding author upon reasonable request.","OA_type":"diamond","scopus_import":"1","date_updated":"2026-10-20T08:15:12Z"},{"arxiv":1,"day":"01","publication_identifier":{"issn":["0004-6361"],"eissn":["1432-0746"]},"supplementarymaterial":"yes","fulldoi":"https://doi.org/10.1051/0004-6361/202557897","department":[{"_id":"JoMa"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Extreme equivalent-width-selected low-mass starbursts at z = 4 − 9: Insights into their role in cosmic reionization","_id":"23049","article_processing_charge":"No","das_tickbox":"1","external_id":{"arxiv":["2510.25647"]},"article_type":"original","has_accepted_license":"1","volume":708,"doi":"10.1051/0004-6361/202557897","oa":1,"researchdata_availability":"no","file":[{"access_level":"open_access","relation":"main_file","date_updated":"2026-10-12T07:19:26Z","success":1,"file_id":"23100","date_created":"2026-10-12T07:19:26Z","content_type":"application/pdf","checksum":"d678534203385bec7579e68e12cc09b4","creator":"dernst","file_size":5918938,"file_name":"2026_AstronomyAstrophysics_Llerena.pdf"}],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"DOAJ_listed":"1","author":[{"full_name":"Llerena, M.","last_name":"Llerena","first_name":"M."},{"full_name":"Pentericci, L.","last_name":"Pentericci","first_name":"L."},{"full_name":"Amorín, R.","first_name":"R.","last_name":"Amorín"},{"full_name":"Ferrara, A.","first_name":"A.","last_name":"Ferrara"},{"last_name":"Dickinson","first_name":"M.","full_name":"Dickinson, M."},{"full_name":"Arevalo-Gonzalez, F.","first_name":"F.","last_name":"Arevalo-Gonzalez"},{"first_name":"A.","last_name":"Calabrò","full_name":"Calabrò, A."},{"last_name":"Napolitano","first_name":"L.","full_name":"Napolitano, L."},{"full_name":"Mascia, Sara","id":"edaf889c-c7cd-11ef-ab1b-bb28c431bd29","last_name":"Mascia","first_name":"Sara"},{"full_name":"Arrabal Haro, P.","first_name":"P.","last_name":"Arrabal Haro"},{"full_name":"Begley, R.","first_name":"R.","last_name":"Begley"},{"last_name":"Cleri","first_name":"N. J.","full_name":"Cleri, N. J."},{"full_name":"Davis, K.","first_name":"K.","last_name":"Davis"},{"last_name":"Hu","first_name":"W.","full_name":"Hu, W."},{"full_name":"Kartaltepe, J. S.","first_name":"J. S.","last_name":"Kartaltepe"},{"full_name":"Koekemoer, A. M.","last_name":"Koekemoer","first_name":"A. M."},{"full_name":"Lucas, R. A.","last_name":"Lucas","first_name":"R. A."},{"first_name":"E.","last_name":"Mcgrath","full_name":"Mcgrath, E."},{"full_name":"Mcleod, D. J.","last_name":"Mcleod","first_name":"D. J."},{"full_name":"Papovich, C.","last_name":"Papovich","first_name":"C."},{"full_name":"Stanton, T. M.","last_name":"Stanton","first_name":"T. M."},{"full_name":"Taylor, A. J.","first_name":"A. J.","last_name":"Taylor"},{"full_name":"Tripodi, R.","first_name":"R.","last_name":"Tripodi"},{"first_name":"X.","last_name":"Wang","full_name":"Wang, X."},{"last_name":"Yung","first_name":"L. Y.A.","full_name":"Yung, L. Y.A."}],"scopus_import":"1","dataavailabilitystatement":"Table A.1 is available at the CDS via https://cdsarc.cds.unistra.fr/viz-bin/cat/J/A+A/708/A152","OA_type":"diamond","date_updated":"2026-10-20T08:15:59Z","status":"public","quality_controlled":"1","PlanS_conform":"1","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"We investigate the properties of extreme emission line galaxies (EELGs) at z = 4 − 9 and their role in reionization. Compact, low-mass galaxies with intense optical emission lines are linked to elevated specific star formation rates (sSFRs) and recent bursts of star formation. Feedback in these systems may enable the leakage of ionizing radiation into the intergalactic medium. Using JWST/NIRSpec spectroscopy from the CAPERS, CEERS, and RUBIES surveys, we compiled 160 NIRCam-selected EELGs in the EGS field. These galaxies show extreme rest-frame equivalent widths (EWs), with a median EW([O III]+Hβ) = 1616 Å and EW(Hα) = 763 Å. They are low-mass (median log(M★/M⊙) = 8.26) with high sSFRs (median 43 Gyr−1), above the z ∼ 6 main sequence. UV slopes are diverse, with a median value of β = −2.0, and only 7% have extremely blue continua (β < −2.6). Emission-line diagnostics suggest stellar populations as the primary ionizing source, although an AGN fraction of 14% cannot be entirely ruled out. These galaxies are efficient ionizing photon producers, with median log(ξion [Hz erg−1]) = 25.37, exceeding typical values at similar redshifts. Escape fractions, however, are heterogeneous: 16% of EELGs at z < 7 show escape fractions > 5% for both Lyα and LyC photons, while 82% lack detectable Lyα emission. The median inferred LyC escape fraction is modest (5%) but enhanced in compact super-Eddington systems with sSFR > 25 Gyr−1. These results indicate that EELGs contribute approximately 16 − 40% of the total ionizing emissivity required to sustain hydrogen reionization. EELGs are extremely compact, with a median effective radius of 0.49 kpc, and exhibit a recent star formation burst. Our analysis indicates that sSFR and star formation rate surface density are the primary drivers of their extreme emission line strengths."}],"OA_place":"publisher","type":"journal_article","date_published":"2026-04-01T00:00:00Z","publisher":"EDP Sciences","ddc":["520"],"month":"04","citation":{"mla":"Llerena, M., et al. “Extreme Equivalent-Width-Selected Low-Mass Starbursts at z = 4 − 9: Insights into Their Role in Cosmic Reionization.” Astronomy & Astrophysics, vol. 708, A152, EDP Sciences, 2026, doi:10.1051/0004-6361/202557897.","chicago":"Llerena, M., L. Pentericci, R. Amorín, A. Ferrara, M. Dickinson, F. Arevalo-Gonzalez, A. Calabrò, et al. “Extreme Equivalent-Width-Selected Low-Mass Starbursts at z = 4 − 9: Insights into Their Role in Cosmic Reionization.” Astronomy & Astrophysics. EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202557897.","apa":"Llerena, M., Pentericci, L., Amorín, R., Ferrara, A., Dickinson, M., Arevalo-Gonzalez, F., … Yung, L. Y. A. (2026). Extreme equivalent-width-selected low-mass starbursts at z = 4 − 9: Insights into their role in cosmic reionization. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202557897","short":"M. Llerena, L. Pentericci, R. Amorín, A. Ferrara, M. Dickinson, F. Arevalo-Gonzalez, A. Calabrò, L. Napolitano, S. Mascia, P. Arrabal Haro, R. Begley, N.J. Cleri, K. Davis, W. Hu, J.S. Kartaltepe, A.M. Koekemoer, R.A. Lucas, E. Mcgrath, D.J. Mcleod, C. Papovich, T.M. Stanton, A.J. Taylor, R. Tripodi, X. Wang, L.Y.A. Yung, Astronomy & Astrophysics 708 (2026).","ieee":"M. Llerena et al., “Extreme equivalent-width-selected low-mass starbursts at z = 4 − 9: Insights into their role in cosmic reionization,” Astronomy & Astrophysics, vol. 708. EDP Sciences, 2026.","ista":"Llerena M, Pentericci L, Amorín R, Ferrara A, Dickinson M, Arevalo-Gonzalez F, Calabrò A, Napolitano L, Mascia S, Arrabal Haro P, Begley R, Cleri NJ, Davis K, Hu W, Kartaltepe JS, Koekemoer AM, Lucas RA, Mcgrath E, Mcleod DJ, Papovich C, Stanton TM, Taylor AJ, Tripodi R, Wang X, Yung LYA. 2026. Extreme equivalent-width-selected low-mass starbursts at z = 4 − 9: Insights into their role in cosmic reionization. Astronomy & Astrophysics. 708, A152.","ama":"Llerena M, Pentericci L, Amorín R, et al. Extreme equivalent-width-selected low-mass starbursts at z = 4 − 9: Insights into their role in cosmic reionization. Astronomy & Astrophysics. 2026;708. doi:10.1051/0004-6361/202557897"},"oa_version":"Published Version","publication_status":"published","publication":"Astronomy & Astrophysics","date_created":"2026-10-04T22:01:55Z","year":"2026","file_date_updated":"2026-10-12T07:19:26Z","intvolume":" 708","acknowledgement":"We thank the anonymous referee for the thorough review and constructive suggestions that significantly improved this paper. We also thank Sophia Flury for valuable feedback and insightful comments, which helped refine our interpretation of the results. MLl acknowledges support from the INAF Large Grant 2022 “Extragalactic Surveys with JWST” (PI L. Pentericci), the PRIN 2022 MUR project 2022CB3PJ3 – First Light And Galaxy aSsembly (FLAGS) funded by the European Union – Next Generation EU, the INAF Mini-grant 2024 “Galaxies in the epoch of Reionization and their analogs at lower redshift” (PI M. Llerena), and the Large Grant RF 2023 F.O. 1.05.23.01.11 “The MOONS Extragalactic Survey”. RA acknowledges support of Grant PID2023-147386NB-I00 funded by MICIU/AEI/10.13039/501100011033 and by ERDF/EU, and the Severo Ochoa award to the IAA-CSIC CEX2021-001131-S. This work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-03127. Support for program number GO-6368 was provided through a grant from the STScI under NASA contract NAS5-03127. The data were obtained from the Mikulski Archive for Space Telescopes (MAST) at the Space Telescope Science Institute. These observations are associated with program #6368, and can be accessed via doi. Some of the data products presented herein were retrieved from the Dawn JWST Archive (DJA). DJA is an initiative of the Cosmic Dawn Center (DAWN), which is funded by the Danish National Research Foundation under grant DNRF140. These observations are associated with programs #1345, #2750, and #4233. This work has made extensive use of Python packages astropy (Astropy Collaboration 2018), numpy (Harris et al. 2020), Matplotlib (Hunter 2007) and LiMe (Fernández et al. 2024).","article_number":"A152"},{"das_tickbox":"0","article_type":"original","external_id":{"arxiv":["2508.14171"]},"article_processing_charge":"No","has_accepted_license":"1","volume":708,"researchdata_availability":"no","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"file":[{"access_level":"open_access","relation":"main_file","date_updated":"2026-10-12T07:09:27Z","success":1,"date_created":"2026-10-12T07:09:27Z","file_id":"23099","content_type":"application/pdf","creator":"dernst","checksum":"adff12137f194affedd27fa07c82e062","file_name":"2026_AstronomyAstrophysics_Napolitano.pdf","file_size":3265893}],"doi":"10.1051/0004-6361/202556912","oa":1,"arxiv":1,"day":"01","publication_identifier":{"eissn":["1432-0746"],"issn":["0004-6361"]},"department":[{"_id":"JoMa"}],"supplementarymaterial":"yes","fulldoi":"https://doi.org/10.1051/0004-6361/202556912","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"23050","title":"Lyα visibility from z = 4.5 to 11 in the UDS field: Evidence for a high neutral hydrogen fraction and small ionized bubbles at z ∼ 7","publisher":"EDP Sciences","month":"04","ddc":["520"],"date_published":"2026-04-01T00:00:00Z","citation":{"apa":"Napolitano, L., Pentericci, L., Dickinson, M., Arrabal Haro, P., Taylor, A. J., Calabrò, A., … Weiner, B. J. (2026). Lyα visibility from z = 4.5 to 11 in the UDS field: Evidence for a high neutral hydrogen fraction and small ionized bubbles at z ∼ 7. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202556912","mla":"Napolitano, L., et al. “Lyα Visibility from z = 4.5 to 11 in the UDS Field: Evidence for a High Neutral Hydrogen Fraction and Small Ionized Bubbles at z ∼ 7.” Astronomy & Astrophysics, vol. 708, A102, EDP Sciences, 2026, doi:10.1051/0004-6361/202556912.","chicago":"Napolitano, L., L. Pentericci, M. Dickinson, P. Arrabal Haro, A. J. Taylor, A. Calabrò, A. Bhagwat, et al. “Lyα Visibility from z = 4.5 to 11 in the UDS Field: Evidence for a High Neutral Hydrogen Fraction and Small Ionized Bubbles at z ∼ 7.” Astronomy & Astrophysics. EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202556912.","short":"L. Napolitano, L. Pentericci, M. Dickinson, P. Arrabal Haro, A.J. Taylor, A. Calabrò, A. Bhagwat, P. Santini, F. Arevalo-Gonzalez, R. Begley, M. Castellano, B. Ciardi, C.T. Donnan, D. Dottorini, J.S. Dunlop, S.L. Finkelstein, A. Fontana, M. Giavalisco, M. Hirschmann, I. Jung, A.M. Koekemoer, V. Kokorev, M. Llerena, R.A. Lucas, S. Mascia, E. Merlin, P.G. Pérez-González, T.M. Stanton, R. Tripodi, X. Wang, B.J. Weiner, Astronomy & Astrophysics 708 (2026).","ama":"Napolitano L, Pentericci L, Dickinson M, et al. Lyα visibility from z = 4.5 to 11 in the UDS field: Evidence for a high neutral hydrogen fraction and small ionized bubbles at z ∼ 7. Astronomy & Astrophysics. 2026;708. doi:10.1051/0004-6361/202556912","ieee":"L. Napolitano et al., “Lyα visibility from z = 4.5 to 11 in the UDS field: Evidence for a high neutral hydrogen fraction and small ionized bubbles at z ∼ 7,” Astronomy & Astrophysics, vol. 708. EDP Sciences, 2026.","ista":"Napolitano L, Pentericci L, Dickinson M, Arrabal Haro P, Taylor AJ, Calabrò A, Bhagwat A, Santini P, Arevalo-Gonzalez F, Begley R, Castellano M, Ciardi B, Donnan CT, Dottorini D, Dunlop JS, Finkelstein SL, Fontana A, Giavalisco M, Hirschmann M, Jung I, Koekemoer AM, Kokorev V, Llerena M, Lucas RA, Mascia S, Merlin E, Pérez-González PG, Stanton TM, Tripodi R, Wang X, Weiner BJ. 2026. Lyα visibility from z = 4.5 to 11 in the UDS field: Evidence for a high neutral hydrogen fraction and small ionized bubbles at z ∼ 7. Astronomy & Astrophysics. 708, A102."},"oa_version":"Published Version","publication_status":"published","date_created":"2026-10-04T22:01:55Z","year":"2026","publication":"Astronomy & Astrophysics","intvolume":" 708","acknowledgement":"We thank the anonymous referee for the constructive feedback provided. LN acknowledges support from grant “Progetti per Avvio alla Ricerca – Tipo 1, Unveiling Cosmic Dawn: Galaxy Evolution with CAPERS” (AR1241906F947685) and from PRIN 2022 MUR project 2022CB3PJ3 – First Light And Galaxy aSsembly (FLAGS) funded by the European Union – Next Generation EU. LN, LP, AB, and BC acknowledge support from the ERC synergy grant 101166930 – RECAP. This work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-03127. These observations are associated with programs #6368, #4233, #1215, #2565, and #3543. Support for program number GO-6368 was provided through a grant from the STScI under NASA contract NAS5-03127. The data were obtained from the Mikulski Archive for Space Telescopes (MAST) at the Space Telescope Science Institute. These observations can be accessed via DOI. Some of the data products presented in this work were retrieved from the Dawn JWST Archive (DJA). DJA is an initiative of the Cosmic Dawn Center (DAWN), which is funded by the Danish National Research Foundation under grant DNRF140.","article_number":"A102","file_date_updated":"2026-10-12T07:09:27Z","author":[{"full_name":"Napolitano, L.","first_name":"L.","last_name":"Napolitano"},{"first_name":"L.","last_name":"Pentericci","full_name":"Pentericci, L."},{"last_name":"Dickinson","first_name":"M.","full_name":"Dickinson, M."},{"last_name":"Arrabal Haro","first_name":"P.","full_name":"Arrabal Haro, P."},{"first_name":"A. J.","last_name":"Taylor","full_name":"Taylor, A. J."},{"last_name":"Calabrò","first_name":"A.","full_name":"Calabrò, A."},{"full_name":"Bhagwat, A.","first_name":"A.","last_name":"Bhagwat"},{"full_name":"Santini, P.","last_name":"Santini","first_name":"P."},{"first_name":"F.","last_name":"Arevalo-Gonzalez","full_name":"Arevalo-Gonzalez, F."},{"full_name":"Begley, R.","last_name":"Begley","first_name":"R."},{"first_name":"M.","last_name":"Castellano","full_name":"Castellano, M."},{"full_name":"Ciardi, B.","first_name":"B.","last_name":"Ciardi"},{"last_name":"Donnan","first_name":"C. T.","full_name":"Donnan, C. T."},{"full_name":"Dottorini, D.","first_name":"D.","last_name":"Dottorini"},{"first_name":"J. S.","last_name":"Dunlop","full_name":"Dunlop, J. S."},{"last_name":"Finkelstein","first_name":"S. L.","full_name":"Finkelstein, S. L."},{"last_name":"Fontana","first_name":"A.","full_name":"Fontana, A."},{"first_name":"M.","last_name":"Giavalisco","full_name":"Giavalisco, M."},{"first_name":"M.","last_name":"Hirschmann","full_name":"Hirschmann, M."},{"last_name":"Jung","first_name":"I.","full_name":"Jung, I."},{"last_name":"Koekemoer","first_name":"A. M.","full_name":"Koekemoer, A. M."},{"full_name":"Kokorev, V.","first_name":"V.","last_name":"Kokorev"},{"last_name":"Llerena","first_name":"M.","full_name":"Llerena, M."},{"first_name":"R. A.","last_name":"Lucas","full_name":"Lucas, R. A."},{"last_name":"Mascia","first_name":"Sara","full_name":"Mascia, Sara","id":"edaf889c-c7cd-11ef-ab1b-bb28c431bd29"},{"full_name":"Merlin, E.","first_name":"E.","last_name":"Merlin"},{"full_name":"Pérez-González, P. G.","last_name":"Pérez-González","first_name":"P. G."},{"full_name":"Stanton, T. M.","first_name":"T. M.","last_name":"Stanton"},{"full_name":"Tripodi, R.","first_name":"R.","last_name":"Tripodi"},{"last_name":"Wang","first_name":"X.","full_name":"Wang, X."},{"full_name":"Weiner, B. J.","first_name":"B. J.","last_name":"Weiner"}],"scopus_import":"1","OA_type":"diamond","date_updated":"2026-10-20T08:15:36Z","status":"public","quality_controlled":"1","PlanS_conform":"1","OA_place":"publisher","type":"journal_article","language":[{"iso":"eng"}],"abstract":[{"text":"The resonant scattering nature of Lyα photons interacting with neutral hydrogen makes Lyα emitters (LAEs) robust tracers of the intergalactic neutral hydrogen fraction, and thus sensitive probes of cosmic reionization. We present an extensive study of the Lyα evolution from galaxies at 4.5 ≤ z ≤ 11 in the UDS field, observed as part of the CAPERS survey, and complemented with spectra from the DAWN JWST Archive. The combined sample includes 651 spectroscopically confirmed Lyα-break galaxies, among which we find 73 S/N > 3 LAEs in JWST-NIRSpec PRISM spectra. We trace the redshift evolution of the LAE fraction with EW0 > 25 Å (XLyα) between z = 5 and z = 9, extending such an analysis to the UDS field for the first time. At z = 5 and 6, the UDS results agree with the average JWST XLyα values from multiple fields. However, JWST measurements are consistently lower than ground-based results. To investigate this, we compare JWST observations to a population of star-forming galaxies at z ∼ 6 observed with VLT-FORS2. We find that a Lyα slit-loss of 35 ± 10% in JWST spectra accounts for the offset, as the resonant Lyα emission is more spatially extended than the stellar continuum. From z = 6 to 7, the UDS field shows a significant drop in Lyα visibility, from which we infer a neutral hydrogen fraction of XHI = 0.7–0.9. Finally, we identify two robust ionized bubbles at z = 7.29 and 7.77, with radii of Rion = 0.6 and 0.5 physical Mpc and photometric overdensities of N/⟨N⟩ = 3 and 4, based on candidate counts down to the photometric completeness limit. Compared to the large ionized region at z ∼ 7 in the EGS field, these results indicate significant field-to-field variation, supporting a patchy, inhomogeneous reionization process.","lang":"eng"}]},{"PlanS_conform":"1","quality_controlled":"1","status":"public","abstract":[{"text":"The previously inaccessible star formation tracer Paschen-Alpha (Paα) can now be spatially resolved by JWST NIRCam slitless spectroscopy in distant galaxies up to cosmic noon. In the first study of its kind, we combine JWST NGDEEP NIRISS and FRESCO NIRCam slitless spectroscopy to provide the first direct comparison of spatially resolved dust-obscured (traced by Paα) versus unobscured (traced by Hα) star formation across the main sequence. We stacked Paα and Hα emission-line maps, along with stellar continuum images at both wavelengths of 31 galaxies at 1 < z < 1.8 in three bins of stellar mass spanning 7.7 ≤ log(M*/M⊙) < 11. Surface brightness profiles were measured and equivalent width (EW) profiles computed. Increasing Paα and Hα EW profiles with galactocentric radius across all stellar masses probed provides direct evidence for the inside-out growth of galaxies both via dust-obscured and unobscured star formation for the first time. For galaxies predominantly on the main sequence (log(M*/M⊙)≥8.8), a weakly positive (0.1 ± 0.1) Paα/Hα line profile gradient as a function of radius is found at 8.8 ≤ log(M*/M⊙) < 9.9, with a negative (−0.4 ± 0.1) Paα/Hα line profile gradient as a function of radius found at the highest stellar masses of 9.9 ≤ log(M*/M⊙) < 11.0. Low-mass galaxies (7.7 ≤ log(M*/M⊙) < 8.8) with predominantly high specific star formation rates relative to the main sequence are also found to have a negative (−0.5 ± 0.1) Paα/Hα line profile gradient as a function of radius. Our results demonstrate that while inside-out growth via star formation is ubiquitous across the main sequence just after cosmic noon, centrally concentrated dust attenuation is not. Along with other recent work in the literature, our findings now motivate future studies of resolved SFR and dust attenuation profiles in large samples of individual cosmic noon galaxies across the main sequence, aimed at understanding the intrinsic scatter in spatially resolved star formation.","lang":"eng"}],"language":[{"iso":"eng"}],"type":"journal_article","OA_place":"publisher","DOAJ_listed":"1","author":[{"full_name":"Matharu, Jasleen","first_name":"Jasleen","last_name":"Matharu"},{"full_name":"Shen, Lu","last_name":"Shen","first_name":"Lu"},{"first_name":"Irene","last_name":"Shivaei","full_name":"Shivaei, Irene"},{"full_name":"Oesch, Pascal A.","first_name":"Pascal A.","last_name":"Oesch"},{"last_name":"Papovich","first_name":"Casey","full_name":"Papovich, Casey"},{"full_name":"Brammer, Gabriel","last_name":"Brammer","first_name":"Gabriel"},{"full_name":"Reddy, Naveen A.","last_name":"Reddy","first_name":"Naveen A."},{"last_name":"Cheng","first_name":"Yingjie","full_name":"Cheng, Yingjie"},{"last_name":"Van Dokkum","first_name":"Pieter","full_name":"Van Dokkum, Pieter"},{"full_name":"Finkelstein, Steven L.","first_name":"Steven L.","last_name":"Finkelstein"},{"last_name":"Hathi","first_name":"Nimish P.","full_name":"Hathi, Nimish P."},{"first_name":"Jeyhan S.","last_name":"Kartaltepe","full_name":"Kartaltepe, Jeyhan S."},{"last_name":"Koekemoer","first_name":"Anton M.","full_name":"Koekemoer, Anton M."},{"full_name":"Matthee, Jorryt J","id":"7439a258-f3c0-11ec-9501-9df22fe06720","last_name":"Matthee","first_name":"Jorryt J","orcid":"0000-0003-2871-127X"},{"full_name":"Pirzkal, Nor","first_name":"Nor","last_name":"Pirzkal"},{"last_name":"Wilkins","first_name":"Stephen M.","full_name":"Wilkins, Stephen M."},{"last_name":"Wozniak","first_name":"Michael A.","full_name":"Wozniak, Michael A."},{"full_name":"Xiao, Mengyuan","last_name":"Xiao","first_name":"Mengyuan"}],"date_updated":"2026-10-20T08:16:24Z","scopus_import":"1","OA_type":"diamond","year":"2026","publication":"Astronomy & Astrophysics","date_created":"2026-10-04T22:01:55Z","publication_status":"published","file_date_updated":"2026-10-12T07:31:23Z","article_number":"A33","acknowledgement":"JM is grateful to the Max Planck Society for the MPIA Prize Fellowship and to the Cosmic Dawn Center for the DAWN Fellowship. This work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope. The raw data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with JWST Cycle 1 GO programs #1895 and #2079. Support for both programs was provided by NASA through a grant from the Space Telescope Science Institute, which is operated by the Associations of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-26555. The Cosmic Dawn Center (DAWN) is funded by the Danish National Research Foundation under grant DNRF140. This work has received funding from the Swiss State Secretariat for Education, Research and Innovation (SERI) under contract number MB22.00072, as well as from the Swiss National Science Foundation (SNSF) through project grant 200020_207349. This work benefited from support from the George P. and Cynthia Woods Mitchell Institute for Fundamental Physics and Astronomy at Texas A&M University. CP thanks Marsha and Ralph Schilling for generous support of this research.","intvolume":" 708","date_published":"2026-04-01T00:00:00Z","ddc":["520"],"month":"04","publisher":"EDP Sciences","citation":{"short":"J. Matharu, L. Shen, I. Shivaei, P.A. Oesch, C. Papovich, G. Brammer, N.A. Reddy, Y. Cheng, P. Van Dokkum, S.L. Finkelstein, N.P. Hathi, J.S. Kartaltepe, A.M. Koekemoer, J.J. Matthee, N. Pirzkal, S.M. Wilkins, M.A. Wozniak, M. Xiao, Astronomy & Astrophysics 708 (2026).","chicago":"Matharu, Jasleen, Lu Shen, Irene Shivaei, Pascal A. Oesch, Casey Papovich, Gabriel Brammer, Naveen A. Reddy, et al. “A First Look at a Complete View of Spatially Resolved Star Formation at 1 < z < 1.8 with JWST NGDEEP+FRESCO Slitless Spectroscopy.” Astronomy & Astrophysics. EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202558205.","mla":"Matharu, Jasleen, et al. “A First Look at a Complete View of Spatially Resolved Star Formation at 1 < z < 1.8 with JWST NGDEEP+FRESCO Slitless Spectroscopy.” Astronomy & Astrophysics, vol. 708, A33, EDP Sciences, 2026, doi:10.1051/0004-6361/202558205.","apa":"Matharu, J., Shen, L., Shivaei, I., Oesch, P. A., Papovich, C., Brammer, G., … Xiao, M. (2026). A first look at a complete view of spatially resolved star formation at 1 < z < 1.8 with JWST NGDEEP+FRESCO slitless spectroscopy. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202558205","ieee":"J. Matharu et al., “A first look at a complete view of spatially resolved star formation at 1 < z < 1.8 with JWST NGDEEP+FRESCO slitless spectroscopy,” Astronomy & Astrophysics, vol. 708. EDP Sciences, 2026.","ista":"Matharu J, Shen L, Shivaei I, Oesch PA, Papovich C, Brammer G, Reddy NA, Cheng Y, Van Dokkum P, Finkelstein SL, Hathi NP, Kartaltepe JS, Koekemoer AM, Matthee JJ, Pirzkal N, Wilkins SM, Wozniak MA, Xiao M. 2026. A first look at a complete view of spatially resolved star formation at 1 < z < 1.8 with JWST NGDEEP+FRESCO slitless spectroscopy. Astronomy & Astrophysics. 708, A33.","ama":"Matharu J, Shen L, Shivaei I, et al. A first look at a complete view of spatially resolved star formation at 1 < z < 1.8 with JWST NGDEEP+FRESCO slitless spectroscopy. Astronomy & Astrophysics. 2026;708. doi:10.1051/0004-6361/202558205"},"oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"A first look at a complete view of spatially resolved star formation at 1 < z < 1.8 with JWST NGDEEP+FRESCO slitless spectroscopy","_id":"23048","day":"01","publication_identifier":{"eissn":["1432-0746"],"issn":["0004-6361"]},"arxiv":1,"supplementarymaterial":"no","fulldoi":"https://doi.org/10.1051/0004-6361/202558205","department":[{"_id":"JoMa"}],"oa":1,"doi":"10.1051/0004-6361/202558205","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"file":[{"access_level":"open_access","date_updated":"2026-10-12T07:31:23Z","relation":"main_file","success":1,"date_created":"2026-10-12T07:31:23Z","file_id":"23101","content_type":"application/pdf","creator":"dernst","checksum":"875d217ea15192fa1208f3db34a7fad6","file_size":587642,"file_name":"2026_AstronomyAstrophysics_Matharu.pdf"}],"researchdata_availability":"yes","article_processing_charge":"No","external_id":{"arxiv":["2511.15792"]},"article_type":"original","das_tickbox":"0","has_accepted_license":"1","volume":708},{"_id":"23045","title":"The sensitivity and behaviour of the curvature in the échelle diagram of red-giant stars","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"LiBu"}],"fulldoi":"https://doi.org/10.1051/0004-6361/202557690","supplementarymaterial":"yes","day":"01","arxiv":1,"publication_identifier":{"eissn":["1432-0746"],"issn":["0004-6361"]},"researchdata_availability":"no","file":[{"creator":"dernst","checksum":"6f5d496ee876c8ff4bce6924be2cad19","file_size":13650005,"file_name":"2026_AstronomyAstrophysics_Hekker.pdf","file_id":"23077","date_created":"2026-10-07T12:35:39Z","content_type":"application/pdf","relation":"main_file","date_updated":"2026-10-07T12:35:39Z","success":1,"access_level":"open_access"}],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"oa":1,"doi":"10.1051/0004-6361/202557690","has_accepted_license":"1","volume":709,"das_tickbox":"0","article_type":"original","external_id":{"arxiv":["2603.16597"]},"article_processing_charge":"No","OA_place":"publisher","type":"journal_article","language":[{"iso":"eng"}],"abstract":[{"text":"Context. In the convective envelopes of relatively cool (surface temperature ≲6700 K) stars, oscillations are excited by turbulent convection. In these so-called solar-like oscillators, radial oscillation modes appear at nearly equally spaced frequencies. This spacing is referred to as the ‘large-frequency separation’. Deviations from equally spaced frequencies are a result of the internal structure of a star being different from a sphere of ideal gas at constant temperature. Hence, these deviations provide information on the internal structure of the star.\r\n\r\nAims. In this work, we investigate the second-order (quadratic) deviation from uniform spacing, referred to as curvature. We aim to provide homogeneous values for observed red-giant stars, understand differences between the results from observations and predictions from stellar models, and reveal the connection between curvature and stellar structure.\r\n\r\nMethods. We used Kepler data of red-giant stars and computed the curvature for several thousand stars. We compared these to the curvature derived from MESA models. We subsequently investigated the trends and differences between results from observations and models. Finally, we computed sensitivity kernels to identify the stellar region(s) to which the curvature is most sensitive and performed a glitch analysis.\r\n\r\nResults. We found that the curvature is sensitive to evolutionary phase and mass. Interestingly, the observed values and values from models show some discrepancies. Including the surface effect in the model frequencies reduces the discrepancies, though it introduces a frequency-dependent over- or under-estimation of the curvature from the models compared to the observations. From the kernels, we confirmed that the curvature is mostly sensitive to the near-surface layers of the star. The glitch analysis shows that in theory this provides information on the location and strength of the He I and H I ionisation layers.\r\n\r\nConclusions. The curvature provides a probe into the near-surface structure of the star. The deviations between the curvature derived from observations and models call for improvements in the near-surface layers of stellar models.","lang":"eng"}],"quality_controlled":"1","status":"public","PlanS_conform":"1","scopus_import":"1","OA_type":"diamond","date_updated":"2026-10-20T08:14:24Z","author":[{"full_name":"Hekker, S.","last_name":"Hekker","first_name":"S."},{"full_name":"Elsworth, Y.","first_name":"Y.","last_name":"Elsworth"},{"first_name":"S.","last_name":"Basu","full_name":"Basu, S."},{"first_name":"F.","last_name":"Ahlborn","full_name":"Ahlborn, F."},{"full_name":"Ball, W. H.","first_name":"W. H.","last_name":"Ball"},{"full_name":"Bellinger, E. P.","first_name":"E. P.","last_name":"Bellinger"},{"id":"158c74c1-eed5-11ef-8c05-e45f52925cdc","full_name":"Buchele, Lynn","first_name":"Lynn","last_name":"Buchele"},{"full_name":"Espinoza-Rojas, F.","last_name":"Espinoza-Rojas","first_name":"F."}],"DOAJ_listed":"1","intvolume":" 709","article_number":"A84","acknowledgement":"We thank the referee and editor for their comments\r\nand work, which improved the manuscript significantly. We acknowledge funding from the ERC Consolidator Grant ‘DipolarSound’ (grant agreement #\r\n101000296). SB is partially supported by NSF grant AST-2205026. YE acknowledges funding from the Science and Technology Facilities Council (STFC)","file_date_updated":"2026-10-07T12:35:39Z","publication_status":"published","year":"2026","date_created":"2026-10-04T22:01:54Z","publication":"Astronomy & Astrophysics","oa_version":"Published Version","citation":{"apa":"Hekker, S., Elsworth, Y., Basu, S., Ahlborn, F., Ball, W. H., Bellinger, E. P., … Espinoza-Rojas, F. (2026). The sensitivity and behaviour of the curvature in the échelle diagram of red-giant stars. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202557690","mla":"Hekker, S., et al. “The Sensitivity and Behaviour of the Curvature in the Échelle Diagram of Red-Giant Stars.” Astronomy & Astrophysics, vol. 709, A84, EDP Sciences, 2026, doi:10.1051/0004-6361/202557690.","chicago":"Hekker, S., Y. Elsworth, S. Basu, F. Ahlborn, W. H. Ball, E. P. Bellinger, Lynn Buchele, and F. Espinoza-Rojas. “The Sensitivity and Behaviour of the Curvature in the Échelle Diagram of Red-Giant Stars.” Astronomy & Astrophysics. EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202557690.","short":"S. Hekker, Y. Elsworth, S. Basu, F. Ahlborn, W.H. Ball, E.P. Bellinger, L. Buchele, F. Espinoza-Rojas, Astronomy & Astrophysics 709 (2026).","ama":"Hekker S, Elsworth Y, Basu S, et al. The sensitivity and behaviour of the curvature in the échelle diagram of red-giant stars. Astronomy & Astrophysics. 2026;709. doi:10.1051/0004-6361/202557690","ista":"Hekker S, Elsworth Y, Basu S, Ahlborn F, Ball WH, Bellinger EP, Buchele L, Espinoza-Rojas F. 2026. The sensitivity and behaviour of the curvature in the échelle diagram of red-giant stars. Astronomy & Astrophysics. 709, A84.","ieee":"S. Hekker et al., “The sensitivity and behaviour of the curvature in the échelle diagram of red-giant stars,” Astronomy & Astrophysics, vol. 709. EDP Sciences, 2026."},"publisher":"EDP Sciences","month":"05","ddc":["520"],"date_published":"2026-05-01T00:00:00Z"},{"file_date_updated":"2026-10-07T12:13:55Z","intvolume":" 708","article_number":"A355","acknowledgement":"AL was funded by Contrat Doctoral Spécifique Normaliens during this work. GL, EL and NP acknowledge funding from\r\nERC CoG project PODCAST No 864965. AL acknowledges funding\r\nfrom ERC StG project Calcifer No 101165631. We used Mathematica\r\n(Wolfram Research Inc, 2024).\r\n","publication_status":"published","date_created":"2026-10-04T22:01:54Z","year":"2026","publication":"Astronomy & Astrophysics","citation":{"ama":"Leclerc A, Laibe G, Lynch E, Perez N. Radial modes of pressure bumps and dips in astrophysical discs. Astronomy & Astrophysics. 2026;708. doi:10.1051/0004-6361/202558428","ieee":"A. Leclerc, G. Laibe, E. Lynch, and N. Perez, “Radial modes of pressure bumps and dips in astrophysical discs,” Astronomy & Astrophysics, vol. 708. EDP Sciences, 2026.","ista":"Leclerc A, Laibe G, Lynch E, Perez N. 2026. Radial modes of pressure bumps and dips in astrophysical discs. Astronomy & Astrophysics. 708, A355.","short":"A. Leclerc, G. Laibe, E. Lynch, N. Perez, Astronomy & Astrophysics 708 (2026).","apa":"Leclerc, A., Laibe, G., Lynch, E., & Perez, N. (2026). Radial modes of pressure bumps and dips in astrophysical discs. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202558428","chicago":"Leclerc, Armand, Guillaume Laibe, Elliot Lynch, and Nicolas Perez. “Radial Modes of Pressure Bumps and Dips in Astrophysical Discs.” Astronomy & Astrophysics. EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202558428.","mla":"Leclerc, Armand, et al. “Radial Modes of Pressure Bumps and Dips in Astrophysical Discs.” Astronomy & Astrophysics, vol. 708, A355, EDP Sciences, 2026, doi:10.1051/0004-6361/202558428."},"oa_version":"Published Version","date_published":"2026-04-01T00:00:00Z","publisher":"EDP Sciences","ddc":["520"],"month":"04","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Aims. We investigate signatures of pressure extrema on global oscillations in discs.\r\n\r\nMethods. We used the framework of wave topology to establish a generalised local dispersion relation that includes pressure gradients. We highlight the influence of a previously unrecognised epicyclic–acoustic frequency, and we derive an analytical criterion for the existence of a branch of modes transiting between the inertial and the pressure bands, known as topological modes.\r\n\r\nResults. We find that pressure extrema consist of wave guides in which such topological modes propagate. The fundamental mode trapped at a pressure bump can propagate at any frequency, allowing it to resonate with any temporal forcing. Conversely, the fundamental mode associated with a pressure dip propagates at any vertical phase velocity. These specific features make them attractive candidates for future discoseismology."}],"OA_place":"publisher","type":"journal_article","quality_controlled":"1","status":"public","PlanS_conform":"1","dataavailabilitystatement":"The scripts written and used for numerical calculations\r\nare accessible at https://github.com/ArmandLeclerc/\r\nradialStratifDisc.","OA_type":"diamond","scopus_import":"1","date_updated":"2026-10-20T08:14:41Z","DOAJ_listed":"1","author":[{"full_name":"Leclerc, Armand","id":"2a1fb1fc-f373-11ef-901a-87cee43a1217","last_name":"Leclerc","first_name":"Armand"},{"first_name":"Guillaume","last_name":"Laibe","full_name":"Laibe, Guillaume"},{"full_name":"Lynch, Elliot","first_name":"Elliot","last_name":"Lynch"},{"first_name":"Nicolas","last_name":"Perez","full_name":"Perez, Nicolas"}],"corr_author":"1","oa":1,"doi":"10.1051/0004-6361/202558428","project":[{"_id":"914d8549-16d5-11f0-9cad-bbe6324c93a9","grant_number":"101165631","name":"Unveiling the mysteries of stellar dynamics: a pioneering journey in magnetoasteroseismology"}],"keyword":["accretion","accretion disks","hydrodynamics","instabilities","waves","protoplanetary disks"],"researchdata_availability":"no","file":[{"access_level":"open_access","date_updated":"2026-10-07T12:13:55Z","relation":"main_file","success":1,"file_id":"23075","date_created":"2026-10-07T12:13:55Z","content_type":"application/pdf","creator":"dernst","checksum":"868c1be53a4f3e0cf2852a723fcacd08","file_size":10533299,"file_name":"2026_AstronomyAstrophysics_Leclerc.pdf"}],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"volume":708,"has_accepted_license":"1","article_processing_charge":"No","das_tickbox":"1","article_type":"original","external_id":{"arxiv":["2512.05737"]},"title":"Radial modes of pressure bumps and dips in astrophysical discs","_id":"23047","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","supplementarymaterial":"yes","fulldoi":"https://doi.org/10.1051/0004-6361/202558428","department":[{"_id":"LiBu"}],"day":"01","publication_identifier":{"eissn":["1432-0746"],"issn":["0004-6361"]},"arxiv":1},{"file":[{"access_level":"closed","relation":"source_file","date_updated":"2026-08-27T12:48:42Z","date_created":"2026-08-26T12:02:47Z","file_id":"22767","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","creator":"mjavoor","checksum":"f9c2847df9f1ac5a3d60c06b3b81a450","file_name":"2026_Javoor_Manjunath_Thesis.docx","file_size":27430796},{"date_updated":"2026-08-26T12:02:46Z","relation":"main_file","embargo_to":"open_access","access_level":"closed","embargo":"2027-08-21","checksum":"8e9b4c0fcafbccf5c3796eacc9134a08","creator":"mjavoor","file_size":19489230,"file_name":"2026_Javoor_Manjunath_Thesis.pdf","file_id":"22768","date_created":"2026-08-26T12:02:46Z","content_type":"application/pdf"}],"tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"keyword":["Actin cytoskeleton","Cell migration","cryo-electron tomography"],"doi":"10.15479/AT-ISTA-22744","project":[{"_id":"bd980d18-d553-11ed-ba76-ceaa645c97eb","name":"A molecular atlas of Actin filament IDentities in the cell motility machinery","grant_number":"101076260"},{"grant_number":"101071793","name":"Pushing from within: Control of cell shape, integrity and motility by cytoskeletal pushing forces","_id":"bd91e723-d553-11ed-ba76-fe7eeb2185fd"}],"corr_author":"1","article_processing_charge":"No","alternative_title":["ISTA Thesis"],"has_accepted_license":"1","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","OA_embargo":"12","_id":"22744","title":"Large-scale imaging of cellular actin networks at single filament resolution using montage cryo-electron tomography","publication_identifier":{"isbn":["978-3-99078-090-9 "],"issn":["2663-337X"]},"day":"21","page":"121","supervisor":[{"full_name":"Schur, Florian KM","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","last_name":"Schur","first_name":"Florian KM","orcid":"0000-0003-4790-8078"},{"orcid":"0000-0002-6620-9179","first_name":"Michael K","last_name":"Sixt","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K"}],"department":[{"_id":"GradSch"},{"_id":"FlSc"},{"_id":"MiSi"}],"degree_awarded":"PhD","fulldoi":"https://doi.org/10.15479/AT-ISTA-22744","acknowledged_ssus":[{"_id":"Bio"},{"_id":"EM-Fac"},{"_id":"ScienComp"},{"_id":"LifeSc"}],"year":"2026","date_created":"2026-08-21T09:11:04Z","publication_status":"published","acknowledgement":"This work was supported by the ERC StG grant ActinID (PRA01221F1049A) awarded to Florian\r\nSchur, the ERC-SyG grant Pushing from within (P01071793) awarded to Michael Sixt, and by ISTA.\r\nI would like to thank the Scientific Service Units at ISTA for their essential support throughout\r\nthis work. In particular, I am grateful to the Electron Microscopy Facility, Imaging and Optics\r\nFacility, Zebrafish Facility, Scientific Computing Facility, and Lab Support Facility for their services,\r\nand technical support, all of which were important for the successful completion of this project.","file_date_updated":"2026-08-27T12:48:42Z","ddc":["570"],"month":"08","publisher":"Institute of Science and Technology Austria ","date_published":"2026-08-21T00:00:00Z","doi_confirm":"1","citation":{"apa":"Javoor, M. (2026). Large-scale imaging of cellular actin networks at single filament resolution using montage cryo-electron tomography. Institute of Science and Technology Austria . https://doi.org/10.15479/AT-ISTA-22744","mla":"Javoor, Manjunath. Large-Scale Imaging of Cellular Actin Networks at Single Filament Resolution Using Montage Cryo-Electron Tomography. Institute of Science and Technology Austria , 2026, doi:10.15479/AT-ISTA-22744.","chicago":"Javoor, Manjunath. “Large-Scale Imaging of Cellular Actin Networks at Single Filament Resolution Using Montage Cryo-Electron Tomography.” Institute of Science and Technology Austria , 2026. https://doi.org/10.15479/AT-ISTA-22744.","short":"M. Javoor, Large-Scale Imaging of Cellular Actin Networks at Single Filament Resolution Using Montage Cryo-Electron Tomography, Institute of Science and Technology Austria , 2026.","ama":"Javoor M. Large-scale imaging of cellular actin networks at single filament resolution using montage cryo-electron tomography. 2026. doi:10.15479/AT-ISTA-22744","ieee":"M. Javoor, “Large-scale imaging of cellular actin networks at single filament resolution using montage cryo-electron tomography,” Institute of Science and Technology Austria , 2026.","ista":"Javoor M. 2026. Large-scale imaging of cellular actin networks at single filament resolution using montage cryo-electron tomography. Institute of Science and Technology Austria ."},"oa_version":"None","status":"public","type":"dissertation","OA_place":"publisher","related_material":{"record":[{"id":"12334","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"21762"},{"status":"public","relation":"part_of_dissertation","id":"12421"},{"status":"public","id":"19795","relation":"part_of_dissertation"}]},"language":[{"iso":"eng"}],"author":[{"first_name":"Manjunath","last_name":"Javoor","id":"305ab18b-dc7d-11ea-9b2f-b58195228ea2","full_name":"Javoor, Manjunath","orcid":"0000-0003-2311-2112"}],"date_updated":"2026-10-20T08:55:33Z"},{"quality_controlled":"1","status":"public","OA_place":"publisher","type":"journal_article","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"The paraventricular hypothalamus (PVH) controls behavioral and physiologic processes, including appetite, social behavior, autonomic outflow, and pituitary hormone secretion. However, molecular markers for centrally projecting PVH neuron populations remain largely undefined, and a complete census of PVH cell types has not been established. Therefore, we performed extensive single-cell/nucleus RNA sequencing to catalog PVH neuron subtypes and multiplexed error-robust fluorescence in situ hybridization (MERFISH) to map them spatially. Our spatial transcriptomic atlas resolves 26 Sim1+ and 29 GABAergic neuron populations from the PVH and surrounding areas. Additionally, projection-based profiling identified neurons that project to the parabrachial region (PB) and spinal cord, helping to determine PVH populations that regulate satiety and sympathetic nervous system activity, respectively. Notably, activation of PB-projecting PVH neurons expressing Brs3 reduces food intake, and silencing them causes obesity. Together, this atlas contributes high-resolution PVH spatial and circuit-based gene expression profiles, representing a valuable resource for the field of homeostasis."}],"author":[{"last_name":"Li","first_name":"Yuxi","full_name":"Li, Yuxi"},{"full_name":"Butler, Trevor C.","first_name":"Trevor C.","last_name":"Butler"},{"last_name":"Nardone","first_name":"Stefano","full_name":"Nardone, Stefano"},{"last_name":"Jacobs","first_name":"Christopher L.","full_name":"Jacobs, Christopher L."},{"orcid":"0000-0001-5398-6473","full_name":"Douglass, Amelia May Barnett","id":"de5f6fda-80fb-11ef-996f-a8c4ecd8e289","last_name":"Douglass","first_name":"Amelia May Barnett"},{"full_name":"Madara, Joseph C.","first_name":"Joseph C.","last_name":"Madara"},{"full_name":"McDonough, Miriam C.","first_name":"Miriam C.","last_name":"McDonough"},{"full_name":"Tao, Jenkang","first_name":"Jenkang","last_name":"Tao"},{"full_name":"Lowenstein, Elijah D.","first_name":"Elijah D.","last_name":"Lowenstein"},{"last_name":"Wang","first_name":"Luhong","full_name":"Wang, Luhong"},{"last_name":"Pant","first_name":"Deepti","full_name":"Pant, Deepti"},{"full_name":"Walker, Samuel J.","last_name":"Walker","first_name":"Samuel J."},{"full_name":"Wang, Annette","last_name":"Wang","first_name":"Annette"},{"last_name":"Srinivasan","first_name":"Harini","full_name":"Srinivasan, Harini"},{"full_name":"Yang, Zongfang","first_name":"Zongfang","last_name":"Yang"},{"full_name":"Campbell, John N.","first_name":"John N.","last_name":"Campbell"},{"first_name":"Linus T.","last_name":"Tsai","full_name":"Tsai, Linus T."},{"first_name":"Bradford B.","last_name":"Lowell","full_name":"Lowell, Bradford B."},{"last_name":"Resch","first_name":"Jon M.","full_name":"Resch, Jon M."}],"DOAJ_listed":"1","OA_type":"gold","scopus_import":"1","date_updated":"2026-10-20T08:58:10Z","publication_status":"published","publication":"Cell Reports","year":"2026","date_created":"2026-04-16T13:51:29Z","intvolume":" 45","acknowledgement":"We would like to thank Drs. Mark Andermann, Joel Geerling, and Clifford\r\nSaper, as well as the Lowell, Tsai, and Resch laboratories for helpful discussions;\r\nAlysia Berns, Jia Yu, and Yanfang Li for technical support; the BNORC\r\nFunctional Genomics and Bioinformatics Core (P30DK046200) and the Iowa\r\nInstitute for Human Genetics Genomics Division (IIHG, RRID: SCR_023422)\r\nfor helpful discussions and technical assistance with sc/snRNA-seq; Zachary\r\nNiziolek and the Bauer Core Facility at Harvard University, the BIDMC Flow Cytometry\r\nCore, and Heath Vignes, Michael Shey, and Thomas Kaufman of the\r\nFlow Cytometry Facility at the University of Iowa Carver College of Medicine\r\nfor helpful discussions and technical support; the ICCB-Longwood Screening\r\nFacility of Harvard Medical School for assistance with the snRNA-seq\r\nexperiments; Dr. Sayak Mitter and Vizgen support for technical assistance\r\nwith the MERSCOPE platform; and Mara Jendro and Li-Chun (Queena) Lin\r\nfor their assistance with MERSCOPE experiments within the Iowa\r\nNeuroBank Core in the Iowa Neuroscience Institute at the University of Iowa\r\nCarver College of Medicine. This research was funded by the following NIH\r\ngrants to L.T.T.: R01DK128406; to B.B.L.: R01DK075632, R01DK134427,\r\nand R01DK096010; to J.M.R.: R00HL144923 and R01NS141072; and to M.C.M.: F31HL170784; T.C.B. and M.C.M. were supported by a pharmacological\r\nsciences predoctoral training grant T32GM144636. Additional funding\r\nto J.M.R. came from the American Heart Association (AHA 935362), a University\r\nof Iowa Fraternal Order of Eagles Diabetes Research Center Pilot and\r\nFeasibility Catalyst Grant, and an Iowa Neuroscience Institute Early Stage\r\nInvestigator award from the Carver Trust. Y.L. was supported by a predoctoral\r\nfellowship from the American Heart Association (AHA 25PRE1372983). A.M.D.\r\nwas supported by a postdoctoral fellowship from the Charles A. King Trust.","article_number":"116904","file_date_updated":"2026-05-04T11:58:51Z","publisher":"Cell Press","month":"02","ddc":["570"],"date_published":"2026-02-24T00:00:00Z","pmid":1,"oa_version":"Published Version","citation":{"apa":"Li, Y., Butler, T. C., Nardone, S., Jacobs, C. L., Douglass, A. M., Madara, J. C., … Resch, J. M. (2026). A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types. Cell Reports. Cell Press. https://doi.org/10.1016/j.celrep.2025.116904","mla":"Li, Yuxi, et al. “A Spatial and Projection-Based Transcriptomic Atlas of Paraventricular Hypothalamic Cell Types.” Cell Reports, vol. 45, no. 2, 116904, Cell Press, 2026, doi:10.1016/j.celrep.2025.116904.","chicago":"Li, Yuxi, Trevor C. Butler, Stefano Nardone, Christopher L. Jacobs, Amelia M. Douglass, Joseph C. Madara, Miriam C. McDonough, et al. “A Spatial and Projection-Based Transcriptomic Atlas of Paraventricular Hypothalamic Cell Types.” Cell Reports. Cell Press, 2026. https://doi.org/10.1016/j.celrep.2025.116904.","short":"Y. Li, T.C. Butler, S. Nardone, C.L. Jacobs, A.M. Douglass, J.C. Madara, M.C. McDonough, J. Tao, E.D. Lowenstein, L. Wang, D. Pant, S.J. Walker, A. Wang, H. Srinivasan, Z. Yang, J.N. Campbell, L.T. Tsai, B.B. Lowell, J.M. Resch, Cell Reports 45 (2026).","ama":"Li Y, Butler TC, Nardone S, et al. A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types. Cell Reports. 2026;45(2). doi:10.1016/j.celrep.2025.116904","ieee":"Y. Li et al., “A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types,” Cell Reports, vol. 45, no. 2. Cell Press, 2026.","ista":"Li Y, Butler TC, Nardone S, Jacobs CL, Douglass AM, Madara JC, McDonough MC, Tao J, Lowenstein ED, Wang L, Pant D, Walker SJ, Wang A, Srinivasan H, Yang Z, Campbell JN, Tsai LT, Lowell BB, Resch JM. 2026. A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types. Cell Reports. 45(2), 116904."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"21744","title":"A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types","publication_identifier":{"eissn":["2211-1247"],"issn":["2639-1856"]},"day":"24","department":[{"_id":"AmDo"}],"fulldoi":"https://doi.org/10.1016/j.celrep.2025.116904","tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"file":[{"success":1,"relation":"main_file","date_updated":"2026-05-04T11:58:51Z","access_level":"open_access","file_size":38532865,"file_name":"2026_CellReports_Li.pdf","checksum":"82098dd9d0ca609119f9f2c6beb4fc1e","creator":"dernst","content_type":"application/pdf","file_id":"21793","date_created":"2026-05-04T11:58:51Z"}],"oa":1,"doi":"10.1016/j.celrep.2025.116904","issue":"2","external_id":{"pmid":["41581146"]},"article_type":"original","article_processing_charge":"Yes","volume":45,"has_accepted_license":"1"},{"fulldoi":"https://doi.org/10.1016/j.cub.2026.02.023","acknowledged_ssus":[{"_id":"MassSpec"},{"_id":"Bio"},{"_id":"LifeSc"}],"department":[{"_id":"JiFr"}],"day":"23","publication_identifier":{"issn":["0960-9822"]},"page":"1468-1480.e6","title":"Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization","_id":"21490","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","has_accepted_license":"1","volume":36,"article_processing_charge":"Yes (via OA deal)","article_type":"original","external_id":{"pmid":["41831441"]},"corr_author":"1","issue":"6","doi":"10.1016/j.cub.2026.02.023","project":[{"name":"Cyclic nucleotides as second messengers in plants","grant_number":"101142681","_id":"8f347782-16d5-11f0-9cad-8c19706ee739"},{"_id":"bd906599-d553-11ed-ba76-abf8547645d7","grant_number":"E271","name":"Identification of a novel regulator in auxin canalization"}],"oa":1,"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"file":[{"success":1,"relation":"main_file","date_updated":"2026-03-24T08:34:37Z","access_level":"open_access","file_size":12986894,"file_name":"2026_CurrentBiology_Li.pdf","checksum":"fe6c41fdab58a55df5f2a5860c02acdc","creator":"dernst","content_type":"application/pdf","file_id":"21496","date_created":"2026-03-24T08:34:37Z"}],"OA_type":"hybrid","date_updated":"2026-10-20T08:57:40Z","author":[{"last_name":"Li","first_name":"Mingyue","full_name":"Li, Mingyue","id":"01f96916-0235-11eb-9379-a323192643b7"},{"first_name":"Nikola","last_name":"Rydza","full_name":"Rydza, Nikola"},{"full_name":"Mazur, Ewa","last_name":"Mazur","first_name":"Ewa"},{"last_name":"Molnar","first_name":"Gergely","full_name":"Molnar, Gergely","id":"34F1AF46-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Nodzyński, Tomasz","last_name":"Nodzyński","first_name":"Tomasz"},{"orcid":"0000-0002-8302-7596","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","first_name":"Jiří"}],"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Auxin canalization is a self-organizing process that governs the flexible formation of vasculature by reinforcing the formation of auxin transport channels. A key prerequisite is the feedback between auxin signaling and directional auxin transport, mediated by PIN transporters. Despite the developmental importance of canalization, the molecular components linking auxin perception to the regulation of PIN auxin transporters remain poorly understood. Here, we identify TOW, a novel and essential component of auxin canalization that links intracellular auxin signaling with cell surface auxin perception. TOW is regulated downstream of TIR1/AFB-Aux/IAA-WRKY23 transcriptional auxin signaling. tow mutants exhibit defects in regeneration and de novo vasculature formation, along with impaired formation of polarized, PIN-expressing auxin channels. At the subcellular level, these mutants display disrupted auxin-induced PIN polarization and altered PIN endocytic trafficking dynamics. TOW localizes predominantly to the plasma membrane, where it interacts with receptor-like kinases involved in auxin canalization, including the TMK1 auxin co-receptor and the CAMEL-CANAR complex. TOW promotes PIN interaction with these kinases and stabilizes PINs at the cell surface. Together, our findings identify TOW as a molecular link between intracellular and cell surface auxin signaling mechanisms that converge on PIN trafficking and polarity, providing new insights into how auxin signaling regulates directional auxin transport for the self-organizing formation of vasculature during flexible plant development."}],"OA_place":"publisher","type":"journal_article","status":"public","quality_controlled":"1","PlanS_conform":"1","citation":{"ieee":"M. Li, N. Rydza, E. Mazur, G. Molnar, T. Nodzyński, and J. Friml, “Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization,” Current Biology, vol. 36, no. 6. Cell Press, p. 1468–1480.e6, 2026.","ista":"Li M, Rydza N, Mazur E, Molnar G, Nodzyński T, Friml J. 2026. Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization. Current Biology. 36(6), 1468–1480.e6.","ama":"Li M, Rydza N, Mazur E, Molnar G, Nodzyński T, Friml J. Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization. Current Biology. 2026;36(6):1468-1480.e6. doi:10.1016/j.cub.2026.02.023","short":"M. Li, N. Rydza, E. Mazur, G. Molnar, T. Nodzyński, J. Friml, Current Biology 36 (2026) 1468–1480.e6.","chicago":"Li, Mingyue, Nikola Rydza, Ewa Mazur, Gergely Molnar, Tomasz Nodzyński, and Jiří Friml. “Receptor-like-Kinase-Interacting Protein TOW Stabilizes PIN Transporters for Auxin Canalization.” Current Biology. Cell Press, 2026. https://doi.org/10.1016/j.cub.2026.02.023.","mla":"Li, Mingyue, et al. “Receptor-like-Kinase-Interacting Protein TOW Stabilizes PIN Transporters for Auxin Canalization.” Current Biology, vol. 36, no. 6, Cell Press, 2026, p. 1468–1480.e6, doi:10.1016/j.cub.2026.02.023.","apa":"Li, M., Rydza, N., Mazur, E., Molnar, G., Nodzyński, T., & Friml, J. (2026). Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2026.02.023"},"oa_version":"Published Version","date_published":"2026-03-23T00:00:00Z","pmid":1,"publisher":"Cell Press","month":"03","ddc":["580"],"file_date_updated":"2026-03-24T08:34:37Z","intvolume":" 36","acknowledgement":"We thank Dr. Z. Ge (ISTA) for providing vectors for the CRISPR-Cas9 system, Dr. Armel Nicolas and Dr. Bella Bruszel for phosphoproteomic analysis, Prof. Michael Wrzaczek (Czech Academy of Sciences, Czechia) for valuable suggestions, and Prof. Maciek Adamowski (University of Gdańsk) for technical assistance. We also acknowledge the support of the Mass Spectrometry and Proteomics Facility, the Imaging & Optics Facility, and the Lab Support Facility at the Institute of Science and Technology Austria. This research was supported by the Scientific Service Units (SSU) of ISTA, utilizing resources provided by the Imaging & Optics Facility (IOF) and the Lab Support Facility (LSF). The work conducted by the Friml group was funded by the European Research Council (ERC) under grant agreement no. 101142681 (CYNIPS) and by the Austrian Science Fund (FWF) under project ESP271. We acknowledge the core facility CELLIM supported by MEYS CR (LM2023050 Czech-BioImaging) and the Plant Sciences Core Facility of CEITEC Masaryk University. E.M. received support from the National Science Centre (NCN), Poland, through the OPUS call within the Weave programme (grant no. 2021/43/I/NZ1/01835). T.N. received support from TowArds Next GENeration Crops, reg. no. CZ.02.01.01/00/22_008/0004581 of the ERDF Programme Johannes Amos Comenius.","publication_status":"published","publication":"Current Biology","year":"2026","date_created":"2026-03-23T15:11:16Z"},{"department":[{"_id":"AlMi"}],"fulldoi":"https://doi.org/10.1016/j.molcel.2026.01.021","publication_identifier":{"issn":["1097-2765"]},"day":"19","page":"625-639.e8","_id":"21509","title":"The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":86,"has_accepted_license":"1","article_type":"original","external_id":{"pmid":["41679301"]},"article_processing_charge":"Yes (in subscription journal)","issue":"4","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"file":[{"date_updated":"2026-03-30T12:04:38Z","relation":"main_file","success":1,"access_level":"open_access","creator":"dernst","checksum":"e16a7315b64a706184b177ea1621523c","file_name":"2026_MolecularCell_Weiss.pdf","file_size":9786677,"file_id":"21510","date_created":"2026-03-30T12:04:38Z","content_type":"application/pdf"}],"doi":"10.1016/j.molcel.2026.01.021","oa":1,"date_updated":"2026-10-20T08:57:55Z","scopus_import":"1","OA_type":"hybrid","author":[{"full_name":"Weiss, Joscha","first_name":"Joscha","last_name":"Weiss"},{"full_name":"Vecchia, Luca","last_name":"Vecchia","first_name":"Luca"},{"last_name":"Domjan","first_name":"David","full_name":"Domjan, David"},{"last_name":"Cavadini","first_name":"Simone","full_name":"Cavadini, Simone"},{"first_name":"Anton","last_name":"Sabantsev","full_name":"Sabantsev, Anton"},{"last_name":"Kempf","first_name":"Georg","full_name":"Kempf, Georg"},{"last_name":"Pathare","first_name":"Ganesh R.","full_name":"Pathare, Ganesh R."},{"first_name":"Klaus","last_name":"Brackmann","full_name":"Brackmann, Klaus"},{"orcid":"0000-0002-6080-839X","last_name":"Michael","first_name":"Alicia","full_name":"Michael, Alicia","id":"6437c950-2a03-11ee-914d-d6476dd7b75c"},{"full_name":"Kater, Lukas","first_name":"Lukas","last_name":"Kater"},{"last_name":"Hietter-Pfeiffer","first_name":"Eric","full_name":"Hietter-Pfeiffer, Eric"},{"first_name":"Mina","last_name":"Haddawi","full_name":"Haddawi, Mina"},{"last_name":"Kuber","first_name":"Urja P.","full_name":"Kuber, Urja P."},{"full_name":"Mühlhäusser, Sandra","last_name":"Mühlhäusser","first_name":"Sandra"},{"first_name":"Ralph S.","last_name":"Grand","full_name":"Grand, Ralph S."},{"full_name":"Stadler, Michael B.","first_name":"Michael B.","last_name":"Stadler"},{"full_name":"Deindl, Sebastian","first_name":"Sebastian","last_name":"Deindl"},{"first_name":"Nicolas H.","last_name":"Thomä","full_name":"Thomä, Nicolas H."}],"type":"journal_article","OA_place":"publisher","abstract":[{"lang":"eng","text":"Chromatin remodeling complexes mobilize nucleosomes and promote transcription factor (TF) binding. Using ensemble and single-molecule assays combined with cryo-electron microscopy (cryo-EM), we studied the interaction between pioneer TFs OCT4–SOX2 and the human BRG1/BRM-associated factor (BAF) complex on nucleosomes. BAF engages TF-bound substrates in two orientations, placing OCT4–SOX2 at either the remodeler ENTRY or EXIT site. At the ENTRY site, OCT4–SOX2 initially coexists with BAF without structural interference. However, continued DNA translocation is expected to cause collisions with bound TFs, which can trigger remodeling direction reversals or may induce TF dissociation. To accommodate TFs at the EXIT site, BAF undergoes structural rearrangements, and ensemble assays reveal a nucleosome subpopulation translocating away from TF-binding sites. Moreover, single-molecule experiments show that nucleosome-bound BAF frequently changes remodeling direction, and we identify an ADP-bound remodeler conformation as a potential intermediate. Together, these findings reveal key aspects of the conformational dynamics and remodeling outcomes underlying BAF processing of TF-bound nucleosomes."}],"language":[{"iso":"eng"}],"PlanS_conform":"1","quality_controlled":"1","status":"public","citation":{"short":"J. Weiss, L. Vecchia, D. Domjan, S. Cavadini, A. Sabantsev, G. Kempf, G.R. Pathare, K. Brackmann, A.K. Michael, L. Kater, E. Hietter-Pfeiffer, M. Haddawi, U.P. Kuber, S. Mühlhäusser, R.S. Grand, M.B. Stadler, S. Deindl, N.H. Thomä, Molecular Cell 86 (2026) 625–639.e8.","apa":"Weiss, J., Vecchia, L., Domjan, D., Cavadini, S., Sabantsev, A., Kempf, G., … Thomä, N. H. (2026). The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2. Molecular Cell. Cell Press. https://doi.org/10.1016/j.molcel.2026.01.021","chicago":"Weiss, Joscha, Luca Vecchia, David Domjan, Simone Cavadini, Anton Sabantsev, Georg Kempf, Ganesh R. Pathare, et al. “The Human BAF Chromatin Remodeler Processes Nucleosomes Bound by Pioneer Transcription Factors OCT4–SOX2.” Molecular Cell. Cell Press, 2026. https://doi.org/10.1016/j.molcel.2026.01.021.","mla":"Weiss, Joscha, et al. “The Human BAF Chromatin Remodeler Processes Nucleosomes Bound by Pioneer Transcription Factors OCT4–SOX2.” Molecular Cell, vol. 86, no. 4, Cell Press, 2026, p. 625–639.e8, doi:10.1016/j.molcel.2026.01.021.","ama":"Weiss J, Vecchia L, Domjan D, et al. The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2. Molecular Cell. 2026;86(4):625-639.e8. doi:10.1016/j.molcel.2026.01.021","ieee":"J. Weiss et al., “The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2,” Molecular Cell, vol. 86, no. 4. Cell Press, p. 625–639.e8, 2026.","ista":"Weiss J, Vecchia L, Domjan D, Cavadini S, Sabantsev A, Kempf G, Pathare GR, Brackmann K, Michael AK, Kater L, Hietter-Pfeiffer E, Haddawi M, Kuber UP, Mühlhäusser S, Grand RS, Stadler MB, Deindl S, Thomä NH. 2026. The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2. Molecular Cell. 86(4), 625–639.e8."},"oa_version":"Published Version","month":"02","ddc":["570"],"publisher":"Cell Press","pmid":1,"date_published":"2026-02-19T00:00:00Z","acknowledgement":"We thank D. Hess, V. Iesmantavicius, and J. Seebacher (FMI Proteomics and Protein Analysis Facility) for mass spectrometry support; S. Smallwood, K. Shimada, D. Klein, and M. Schütz-Stoffregen for technical assistance; J. Côté and C. Lachance for critical discussions; and members of the Thomä lab for helpful feedback. Support for this work was provided to N.H.T. by the European Research Council under the European Union’s Horizon 2020 research program (NucEM, no. 884331), the Novartis Research Foundation, the Swiss National Science Foundation (SNF 31003A_179541, 310030_214852, and Sinergia CRSII5_186230), and the Swiss Cancer Research (KFS-4980-02-2020 and KFS-5933-08-2023). S.D. was supported by the European Research Council (DONUTS, no. 101092623), the Knut and Alice Wallenberg Foundation (2024.0012), the Cancerfonden (25 4453 Pj), and the Swedish Research Council (VR 03255). A.K.M. was supported by a Human Frontier Science Program Long-Term Fellowship, and L.V. was supported by an EMBO fellowship (ALTF 549-2021).","intvolume":" 86","file_date_updated":"2026-03-30T12:04:38Z","publication":"Molecular Cell","year":"2026","date_created":"2026-03-30T11:58:48Z","publication_status":"published"},{"day":"20","page":"1903-1917.e5","publication_identifier":{"eissn":["1879-0445"],"issn":["0960-9822"]},"fulldoi":"https://doi.org/10.1016/j.cub.2026.02.068","department":[{"_id":"AnSa"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis","_id":"21761","article_processing_charge":"Yes (in subscription journal)","external_id":{"pmid":["41881011"]},"article_type":"original","volume":36,"has_accepted_license":"1","doi":"10.1016/j.cub.2026.02.068","oa":1,"tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"file":[{"file_size":13402043,"file_name":"2026_CurrentBiology_PerezVerdugo.pdf","creator":"dernst","checksum":"80ae45457b4682c50c84f54de15aa9a8","content_type":"application/pdf","file_id":"21774","date_created":"2026-04-28T13:13:40Z","success":1,"relation":"main_file","date_updated":"2026-04-28T13:13:40Z","access_level":"open_access"}],"issue":"8","author":[{"last_name":"Perez Verdugo","first_name":"Fernanda L","full_name":"Perez Verdugo, Fernanda L","id":"4ecec223-9070-11ef-a0a9-bc76077bea8d"},{"full_name":"Maniou, Eirini","first_name":"Eirini","last_name":"Maniou"},{"first_name":"Gabriel L.","last_name":"Galea","full_name":"Galea, Gabriel L."},{"full_name":"Banerjee, Shiladitya","last_name":"Banerjee","first_name":"Shiladitya"}],"date_updated":"2026-10-20T08:59:48Z","OA_type":"hybrid","scopus_import":"1","status":"public","quality_controlled":"1","abstract":[{"text":"Neural tube closure is a critical morphogenetic process in vertebrate development, and failure to close cranial regions such as the hindbrain neuropore (HNP) leads to severe congenital malformations. While mechanical forces such as actomyosin purse-string contraction and directional cell crawling have been implicated in driving HNP closure, how these forces organize local cell shape and motion to produce large-scale tissue remodeling remains poorly understood. Using live and fixed imaging of mouse embryos combined with cell-based biophysical modeling, we show that these force-generating mechanisms are insufficient to explain the reproducible patterns of cell elongation and nematic alignment observed at the HNP border. Instead, we show that local anisotropic stress and cytoskeletal organization are required to generate these patterns and promote midline cell motion. Our model captures key features of cell shape dynamics and emergent nematic order, which we confirm experimentally, including the alignment of actin fibers with cell shape and enhanced midline cell speed. Comparative analysis with chick embryos, which lack supracellular purse strings, supports a conserved link between tension generation and cellular patterning. These findings establish a physical framework connecting force generation, cell shape anisotropy, and tissue morphodynamics during epithelial gap closure.","lang":"eng"}],"language":[{"iso":"eng"}],"type":"journal_article","OA_place":"publisher","pmid":1,"date_published":"2026-04-20T00:00:00Z","month":"04","ddc":["570"],"publisher":"Cell Press","citation":{"ista":"Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. 2026. Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. Current Biology. 36(8), 1903–1917.e5.","ieee":"F. L. Perez Verdugo, E. Maniou, G. L. Galea, and S. Banerjee, “Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis,” Current Biology, vol. 36, no. 8. Cell Press, p. 1903–1917.e5, 2026.","ama":"Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. Current Biology. 2026;36(8):1903-1917.e5. doi:10.1016/j.cub.2026.02.068","short":"F.L. Perez Verdugo, E. Maniou, G.L. Galea, S. Banerjee, Current Biology 36 (2026) 1903–1917.e5.","mla":"Perez Verdugo, Fernanda L., et al. “Mechanosensitive Feedback Organizes Cell Shape and Motion during Hindbrain Neuropore Morphogenesis.” Current Biology, vol. 36, no. 8, Cell Press, 2026, p. 1903–1917.e5, doi:10.1016/j.cub.2026.02.068.","chicago":"Perez Verdugo, Fernanda L, Eirini Maniou, Gabriel L. Galea, and Shiladitya Banerjee. “Mechanosensitive Feedback Organizes Cell Shape and Motion during Hindbrain Neuropore Morphogenesis.” Current Biology. Cell Press, 2026. https://doi.org/10.1016/j.cub.2026.02.068.","apa":"Perez Verdugo, F. L., Maniou, E., Galea, G. L., & Banerjee, S. (2026). Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2026.02.068"},"oa_version":"Published Version","publication":"Current Biology","year":"2026","date_created":"2026-04-26T22:01:46Z","publication_status":"published","file_date_updated":"2026-04-28T13:13:40Z","acknowledgement":"S.B. acknowledges support from the National Institutes of Health (NIH R35 GM143042) and the National Science Foundation (NSF MCB-2203601). G.L.G. acknowledges support from the Wellcome Trust (211112/Z/18/Z), the Royal Society (RG\\R2\\232082), and the Leverhulme Trust (RPG-2024-147). E.M. acknowledges support from European Union’s Horizon 2021 Marie Sklodowska-Curie grant agreement no. 101067028. F.P.-V. acknowledges support from the NOMIS foundation. The surface subtraction macro is courtesy of Dr. Dale Moulding and available on GitHub (https://github.com/DaleMoulding/Fiji-Macros).","intvolume":" 36"},{"publication_status":"inpress","year":"2026","date_created":"2026-06-08T09:24:25Z","publication":"Neuron","acknowledgement":"We thank all members of the B.B.L. laboratory for helpful discussions. We\r\nthank the BADERC and BNORC transgenic cores (NIH P30DK057521 and\r\nP30DK046200) for performing embryo injections to generate knockin mouse\r\nlines. We also thank the BIDMC Energy Balance Core (supported by NIH\r\nS10OD028635 and the Boston Area Diabetes Endocrinology Research Centers, P30DK135043), where Marissa Cortopassi performed indirect calorimetry experiments and Alexander Banks assisted with data analysis and interpretation. Confocal imaging was performed at BIDMC’s Confocal Imaging\r\nCore. We thank Chen Wu for assistance in designing knockin mouse lines.\r\nThis work was supported by the NIH (R01DK134427, R01DK096010, and\r\nR01DK075632 to B.B.L.). Authors were supported by an EMBO Long-Term\r\nFellowship (770-2018, S.J.W.), a T32 Postdoctoral Training Fellowship\r\n(5T32DK007516, E.D.L.), the Charles A. King Trust Postdoctoral Research\r\nFellowship program (A.M.D.), and a K99 Career Development Award\r\n(K99HL144923, J.M.R.).","date_published":"2026-06-03T00:00:00Z","pmid":1,"publisher":"Cell Press","month":"06","oa_version":"Preprint","citation":{"apa":"Walker, S. J., Lowenstein, E. D., Douglass, A. M., Thomas, C. M. P., Madara, J. C., Kucukdereli, H., … Lowell, B. B. (n.d.). A hypothalamic circuit for anticipating future changes in energy balance. Neuron. Cell Press. https://doi.org/10.1016/j.neuron.2026.05.010","mla":"Walker, Samuel J., et al. “A Hypothalamic Circuit for Anticipating Future Changes in Energy Balance.” Neuron, Cell Press, doi:10.1016/j.neuron.2026.05.010.","chicago":"Walker, Samuel J., Elijah D. Lowenstein, Amelia M. Douglass, Callum M.P. Thomas, Joseph C. Madara, Hakan Kucukdereli, Eunice A. Barbosa-Meillon, Jenkang Tao, Jon M. Resch, and Bradford B. Lowell. “A Hypothalamic Circuit for Anticipating Future Changes in Energy Balance.” Neuron. Cell Press, n.d. https://doi.org/10.1016/j.neuron.2026.05.010.","short":"S.J. Walker, E.D. Lowenstein, A.M. Douglass, C.M.P. Thomas, J.C. Madara, H. Kucukdereli, E.A. Barbosa-Meillon, J. Tao, J.M. Resch, B.B. Lowell, Neuron (n.d.).","ama":"Walker SJ, Lowenstein ED, Douglass AM, et al. A hypothalamic circuit for anticipating future changes in energy balance. Neuron. doi:10.1016/j.neuron.2026.05.010","ieee":"S. J. Walker et al., “A hypothalamic circuit for anticipating future changes in energy balance,” Neuron. Cell Press.","ista":"Walker SJ, Lowenstein ED, Douglass AM, Thomas CMP, Madara JC, Kucukdereli H, Barbosa-Meillon EA, Tao J, Resch JM, Lowell BB. A hypothalamic circuit for anticipating future changes in energy balance. Neuron."},"status":"public","quality_controlled":"1","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"AgRP neurons cause hunger, the drive to seek and consume food. Their activation by fasting is key for survival and is thought to be triggered by feedback when energy stores are low. However, we know that environmental cues can also regulate AgRP neurons since cues that predict future food intake rapidly inhibit AgRP neurons, but is the converse true: can the prediction of future fasting rapidly activate AgRP neurons? Here, we show in mice that such rapid fasting activation of AgRP neurons does occur. This rapid activation is driven by excitatory input from paraventricular hypothalamic (PVH) neurons expressing Sim2, which are bidirectionally sensitive to predictions of future energy state. Thus, cognitively processed contextual information conveyed by PVHSim2 neurons strongly activates AgRP neurons. Lastly, chronic silencing of PVHSim2 neurons causes persistent hypophagia. This PVHSim2-to-AgRP-neuron circuit, by anticipating and preventing negative energy balance, provides an important new dimension of hunger regulation."}],"OA_place":"repository","type":"journal_article","author":[{"full_name":"Walker, Samuel J.","last_name":"Walker","first_name":"Samuel J."},{"first_name":"Elijah D.","last_name":"Lowenstein","full_name":"Lowenstein, Elijah D."},{"last_name":"Douglass","first_name":"Amelia May Barnett","full_name":"Douglass, Amelia May Barnett","id":"de5f6fda-80fb-11ef-996f-a8c4ecd8e289","orcid":"0000-0001-5398-6473"},{"first_name":"Callum M.P.","last_name":"Thomas","full_name":"Thomas, Callum M.P."},{"full_name":"Madara, Joseph C.","first_name":"Joseph C.","last_name":"Madara"},{"full_name":"Kucukdereli, Hakan","last_name":"Kucukdereli","first_name":"Hakan"},{"first_name":"Eunice A.","last_name":"Barbosa-Meillon","full_name":"Barbosa-Meillon, Eunice A."},{"full_name":"Tao, Jenkang","first_name":"Jenkang","last_name":"Tao"},{"full_name":"Resch, Jon M.","last_name":"Resch","first_name":"Jon M."},{"last_name":"Lowell","first_name":"Bradford B.","full_name":"Lowell, Bradford B."}],"OA_type":"green","scopus_import":"1","date_updated":"2026-10-20T09:00:02Z","doi":"10.1016/j.neuron.2026.05.010","oa":1,"keyword":["hunger","hypothalamus","AGRP neurons","neuroscience","metabolism","homeostasis","feeding","food intake","energy balance","appetite"],"article_processing_charge":"No","article_type":"original","external_id":{"pmid":["42235510"]},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2025.09.27.678865"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"A hypothalamic circuit for anticipating future changes in energy balance","_id":"21955","day":"03","publication_identifier":{"eissn":[" 1097-4199"],"issn":["0896-6273"]},"fulldoi":"https://doi.org/10.1016/j.neuron.2026.05.010","department":[{"_id":"AmDo"}]},{"citation":{"short":"M. Riedl, M.K. Sixt, Cell 189 (2026) 3845–3846.","apa":"Riedl, M., & Sixt, M. K. (2026). A new sense for electrical fields. Cell. Cell Press. https://doi.org/10.1016/j.cell.2026.05.038","mla":"Riedl, Michael, and Michael K. Sixt. “A New Sense for Electrical Fields.” Cell, vol. 189, no. 13, Cell Press, 2026, pp. 3845–46, doi:10.1016/j.cell.2026.05.038.","chicago":"Riedl, Michael, and Michael K Sixt. “A New Sense for Electrical Fields.” Cell. Cell Press, 2026. https://doi.org/10.1016/j.cell.2026.05.038.","ama":"Riedl M, Sixt MK. A new sense for electrical fields. Cell. 2026;189(13):3845-3846. doi:10.1016/j.cell.2026.05.038","ista":"Riedl M, Sixt MK. 2026. A new sense for electrical fields. Cell. 189(13), 3845–3846.","ieee":"M. Riedl and M. K. Sixt, “A new sense for electrical fields,” Cell, vol. 189, no. 13. Cell Press, pp. 3845–3846, 2026."},"oa_version":"None","date_published":"2026-06-25T00:00:00Z","publisher":"Cell Press","month":"06","intvolume":" 189","publication_status":"published","publication":"Cell","date_created":"2026-06-28T22:01:34Z","year":"2026","scopus_import":"1","OA_type":"closed access","date_updated":"2026-10-20T09:00:16Z","author":[{"orcid":"0000-0003-4844-6311","full_name":"Riedl, Michael","id":"3BE60946-F248-11E8-B48F-1D18A9856A87","last_name":"Riedl","first_name":"Michael"},{"orcid":"0000-0002-6620-9179","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K","first_name":"Michael K","last_name":"Sixt"}],"language":[{"iso":"eng"}],"abstract":[{"text":"Most cells polarize and migrate in response to electrical fields. In this issue of Cell, Belliveau et al. identify TMEM154/Galvanin, a receptor that serves as a cellular antenna to sense electrical gradients and guide migration toward the cathode.","lang":"eng"}],"type":"journal_article","status":"public","quality_controlled":"1","volume":189,"article_processing_charge":"No","das_tickbox":"0","article_type":"comment","corr_author":"1","issue":"13","doi":"10.1016/j.cell.2026.05.038","researchdata_availability":"no","fulldoi":"https://doi.org/10.1016/j.cell.2026.05.038","supplementarymaterial":"no","department":[{"_id":"MiSi"}],"page":"3845-3846","day":"25","publication_identifier":{"issn":["0092-8674"],"eissn":["1097-4172"]},"title":"A new sense for electrical fields","_id":"22144","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"day":"05","page":"R27-R29","publication_identifier":{"eissn":["1879-0445"],"issn":["0960-9822"]},"fulldoi":"https://doi.org/10.1016/j.cub.2025.11.056","department":[{"_id":"AmDo"},{"_id":"SiHi"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Neuroscience: What doesn’t kill you makes you stronger","_id":"20972","article_processing_charge":"No","article_type":"letter_note","external_id":{"pmid":["41494523"]},"volume":36,"doi":"10.1016/j.cub.2025.11.056","corr_author":"1","issue":"1","author":[{"id":"5d5f6ea4-ef9e-11f0-a10a-85e12a3552af","full_name":"Kücükdereli, Hakan","first_name":"Hakan","last_name":"Kücükdereli"},{"orcid":"0000-0001-5398-6473","full_name":"Douglass, Amelia May Barnett","id":"de5f6fda-80fb-11ef-996f-a8c4ecd8e289","last_name":"Douglass","first_name":"Amelia May Barnett"}],"date_updated":"2026-10-20T08:57:26Z","scopus_import":"1","OA_type":"closed access","status":"public","quality_controlled":"1","abstract":[{"text":"Small amounts of stress are thought to have beneficial effects. A new study reports a mechanism by which the psychedelic drug, psilocybin, causes acute release of stress hormones, despite its known long-term anti-anxiety effects.","lang":"eng"}],"language":[{"iso":"eng"}],"type":"journal_article","pmid":1,"date_published":"2026-01-05T00:00:00Z","month":"01","publisher":"Cell Press","citation":{"chicago":"Kücükdereli, Hakan, and Amelia M. Douglass. “Neuroscience: What Doesn’t Kill You Makes You Stronger.” Current Biology. Cell Press, 2026. https://doi.org/10.1016/j.cub.2025.11.056.","mla":"Kücükdereli, Hakan, and Amelia M. Douglass. “Neuroscience: What Doesn’t Kill You Makes You Stronger.” Current Biology, vol. 36, no. 1, Cell Press, 2026, pp. R27–29, doi:10.1016/j.cub.2025.11.056.","apa":"Kücükdereli, H., & Douglass, A. M. (2026). Neuroscience: What doesn’t kill you makes you stronger. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2025.11.056","short":"H. Kücükdereli, A.M. Douglass, Current Biology 36 (2026) R27–R29.","ista":"Kücükdereli H, Douglass AM. 2026. Neuroscience: What doesn’t kill you makes you stronger. Current Biology. 36(1), R27–R29.","ieee":"H. Kücükdereli and A. M. Douglass, “Neuroscience: What doesn’t kill you makes you stronger,” Current Biology, vol. 36, no. 1. Cell Press, pp. R27–R29, 2026.","ama":"Kücükdereli H, Douglass AM. Neuroscience: What doesn’t kill you makes you stronger. Current Biology. 2026;36(1):R27-R29. doi:10.1016/j.cub.2025.11.056"},"oa_version":"None","year":"2026","publication":"Current Biology","date_created":"2026-01-11T23:01:33Z","intvolume":" 36"},{"day":"11","page":"356-371.e12","publication_identifier":{"eissn":["1878-1551"],"issn":["1534-5807"]},"department":[{"_id":"Bio"},{"_id":"NanoFab"}],"supplementarymaterial":"yes","fulldoi":"https://doi.org/10.1016/j.devcel.2025.10.006","acknowledged_ssus":[{"_id":"NanoFab"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"20859","title":"Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses","external_id":{"pmid":["41192429"]},"article_type":"original","das_tickbox":"1","article_processing_charge":"Yes (in subscription journal)","has_accepted_license":"1","volume":61,"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"file":[{"access_level":"open_access","success":1,"relation":"main_file","date_updated":"2026-07-23T06:26:25Z","content_type":"application/pdf","date_created":"2026-07-23T06:26:25Z","file_id":"22388","file_size":12342817,"file_name":"2026_DevelopmentalCell_CompanyGarrido.pdf","checksum":"52fd52d2d19a4514f8fcc1b40f420ca2","creator":"dernst"}],"researchdata_availability":"upon request","keyword":["thermobiology","cell migration","thermo-adaptability of immune cells"],"doi":"10.1016/j.devcel.2025.10.006","oa":1,"issue":"2","author":[{"last_name":"Company-Garrido","first_name":"Iván","full_name":"Company-Garrido, Iván"},{"last_name":"Zurita Carpio","first_name":"Alberto","full_name":"Zurita Carpio, Alberto"},{"full_name":"Colomer-Rosell, Mariona","first_name":"Mariona","last_name":"Colomer-Rosell"},{"first_name":"Bernard","last_name":"Ciraulo","full_name":"Ciraulo, Bernard"},{"full_name":"Molkenbur, Ronja","first_name":"Ronja","last_name":"Molkenbur"},{"first_name":"Peter","last_name":"Lanzerstorfer","full_name":"Lanzerstorfer, Peter"},{"first_name":"Fabio","last_name":"Pezzano","full_name":"Pezzano, Fabio"},{"last_name":"Agazzi","first_name":"Costanza","full_name":"Agazzi, Costanza"},{"id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","full_name":"Hauschild, Robert","first_name":"Robert","last_name":"Hauschild","orcid":"0000-0001-9843-3522"},{"full_name":"Jain, Saumey","first_name":"Saumey","last_name":"Jain"},{"full_name":"Jacques, Jeroen M.","first_name":"Jeroen M.","last_name":"Jacques"},{"full_name":"Venturini, Valeria","first_name":"Valeria","last_name":"Venturini"},{"last_name":"Knapp","first_name":"Christian","full_name":"Knapp, Christian"},{"full_name":"Xie, Yufei","first_name":"Yufei","last_name":"Xie"},{"orcid":"0000-0001-5145-4609","full_name":"Merrin, Jack","id":"4515C308-F248-11E8-B48F-1D18A9856A87","last_name":"Merrin","first_name":"Jack"},{"first_name":"Julian","last_name":"Weghuber","full_name":"Weghuber, Julian"},{"last_name":"Schaaf","first_name":"Marcel","full_name":"Schaaf, Marcel"},{"full_name":"Quidant, Romain","first_name":"Romain","last_name":"Quidant"},{"id":"3EB04B78-F248-11E8-B48F-1D18A9856A87","full_name":"Kiermaier, Eva","first_name":"Eva","last_name":"Kiermaier","orcid":"0000-0001-6165-5738"},{"full_name":"Ortega Arroyo, Jaime","first_name":"Jaime","last_name":"Ortega Arroyo"},{"orcid":"0000-0003-4088-8633","full_name":"Ruprecht, Verena","id":"4D71A03A-F248-11E8-B48F-1D18A9856A87","last_name":"Ruprecht","first_name":"Verena"},{"orcid":"0000-0002-2670-2217","first_name":"Stefan","last_name":"Wieser","id":"355AA5A0-F248-11E8-B48F-1D18A9856A87","full_name":"Wieser, Stefan"}],"date_updated":"2026-10-20T09:01:14Z","scopus_import":"1","dataavailabilitystatement":"This study did not generate new unique reagents. Data are available upon request.\r\n•The custom-made codes used in this study are available at: https://github.com/mcolomerr/cell_thermo https://github.com/Stefan1980sol/Lymph_entry_simu\r\n• Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.","OA_type":"hybrid","PlanS_conform":"1","quality_controlled":"1","status":"public","type":"journal_article","OA_place":"publisher","abstract":[{"text":"Effective immune responses rely on the efficient migration of leukocytes. Yet, how temperature regulates migration dynamics at the single-cell level has remained poorly understood. Using zebrafish embryos and mouse tissue explants, we found that temperature positively regulates leukocyte migration speed, exploration, and arrival frequencies to wounds and lymph vessels. Complementary 2D and 3D cultures revealed that this thermokinetic control of cell migration is conserved across immune cell types, independently of the 3D tissue environment. By applying precise (sub-)cellular temperature modulation, we identified a rapid and reversible thermo-response that depends on myosin II activity. Small physiological increases in temperature (1°C –2°C), as present during fever-like conditions, profoundly increased immune responses by accelerating arrival times at lymphatic vessels and tissue wounds. These findings identify myosin-II-dependent actomyosin contractility as a critical mechanical structure regulating single-cell thermo-adaptability, with physiological implications for tuning the speed of immune responses in vivo.","lang":"eng"}],"language":[{"iso":"eng"}],"month":"02","ddc":["570"],"publisher":"Cell Press","pmid":1,"date_published":"2026-02-11T00:00:00Z","citation":{"ama":"Company-Garrido I, Zurita Carpio A, Colomer-Rosell M, et al. Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses. Developmental Cell. 2026;61(2):356-371.e12. doi:10.1016/j.devcel.2025.10.006","ista":"Company-Garrido I, Zurita Carpio A, Colomer-Rosell M, Ciraulo B, Molkenbur R, Lanzerstorfer P, Pezzano F, Agazzi C, Hauschild R, Jain S, Jacques JM, Venturini V, Knapp C, Xie Y, Merrin J, Weghuber J, Schaaf M, Quidant R, Kiermaier E, Ortega Arroyo J, Ruprecht V, Wieser S. 2026. Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses. Developmental Cell. 61(2), 356–371.e12.","ieee":"I. Company-Garrido et al., “Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses,” Developmental Cell, vol. 61, no. 2. Cell Press, p. 356–371.e12, 2026.","short":"I. Company-Garrido, A. Zurita Carpio, M. Colomer-Rosell, B. Ciraulo, R. Molkenbur, P. Lanzerstorfer, F. Pezzano, C. Agazzi, R. Hauschild, S. Jain, J.M. Jacques, V. Venturini, C. Knapp, Y. Xie, J. Merrin, J. Weghuber, M. Schaaf, R. Quidant, E. Kiermaier, J. Ortega Arroyo, V. Ruprecht, S. Wieser, Developmental Cell 61 (2026) 356–371.e12.","apa":"Company-Garrido, I., Zurita Carpio, A., Colomer-Rosell, M., Ciraulo, B., Molkenbur, R., Lanzerstorfer, P., … Wieser, S. (2026). Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses. Developmental Cell. Cell Press. https://doi.org/10.1016/j.devcel.2025.10.006","chicago":"Company-Garrido, Iván, Alberto Zurita Carpio, Mariona Colomer-Rosell, Bernard Ciraulo, Ronja Molkenbur, Peter Lanzerstorfer, Fabio Pezzano, et al. “Myosin II Regulates Cellular Thermo-Adaptability and the Efficiency of Immune Responses.” Developmental Cell. Cell Press, 2026. https://doi.org/10.1016/j.devcel.2025.10.006.","mla":"Company-Garrido, Iván, et al. “Myosin II Regulates Cellular Thermo-Adaptability and the Efficiency of Immune Responses.” Developmental Cell, vol. 61, no. 2, Cell Press, 2026, p. 356–371.e12, doi:10.1016/j.devcel.2025.10.006."},"oa_version":"Published Version","publication":"Developmental Cell","year":"2026","date_created":"2025-12-28T23:01:27Z","publication_status":"published","acknowledgement":"The authors would like to acknowledge the Super Resolution Light Microcopy and Nanoscopy (SLN) Facility of ICFO for their support with imaging experiments, Johann Osmond (Nanofabrication laboratory, ICFO) for the design and production of molds for generating confinement coverslip, Merche Rivas for cell culture of immune cells and further support from the CRG Core Facilities for Genomics and Advanced Light Microscopy. We would like to thank Michael Sixt for discussions on this work and the Quidant, Ruprecht, and Wieser lab members for critical reading of the manuscript. This research was supported by the Scientific Service Units (SSU) of IST-Austria through resources provided by the Nanofabrication Facility (NFF). C.A. acknowledges the funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no 847517 and V.V. from the ICFOstepstone – PhD Programme funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no 665884. S.W. acknowledges support through the Spanish Ministry of Economy and Competitiveness via MINECO’s Plan Nacional (BFU2017-86296-P). V.R. acknowledges funding from the European Union’s HORIZON-EIC-2021-PATHFINDEROPEN program under grant agreement no. 101046620 and European Union's Horizon Europe program under the grant agreement no. 101072123. E.K. acknowledges funding by a fellowship of the Ministry of Innovation, Science and Research of North-Rhine-Westphalia (AZ: 421-8.03.03.02-137069) and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC 2151 – 390873048 and by the TRA Life and Health (University of Bonn) as part of the Excellence Strategy of the federal and state governments.","intvolume":" 61","file_date_updated":"2026-07-23T06:26:25Z"},{"supplementarymaterial":"yes","fulldoi":"https://doi.org/10.1016/j.molcel.2025.11.029","department":[{"_id":"AlMi"}],"publication_identifier":{"issn":["1097-2765"],"eissn":["1097-4164"]},"page":"213-230.e7","day":"08","title":"Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii","_id":"20935","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","has_accepted_license":"1","volume":86,"article_processing_charge":"Yes (in subscription journal)","das_tickbox":"1","article_type":"original","issue":"1","oa":1,"doi":"10.1016/j.molcel.2025.11.029","researchdata_availability":"yes","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"file":[{"creator":"dernst","checksum":"96a2f8519124d1a0d9de8d2594bf7147","file_size":26749637,"file_name":"2026_MolecularCell_Kelley.pdf","file_id":"22599","date_created":"2026-07-28T07:38:45Z","content_type":"application/pdf","relation":"main_file","date_updated":"2026-07-28T07:38:45Z","success":1,"access_level":"open_access"}],"dataavailabilitystatement":"Raw EM data are available at the EMPIAR under accession code EMPIAR: EMPIAR-11830. Annotation and processing information for all 1,829 tomograms are provided in spreadsheet format.153 The following subtomogram averages have been deposited at the Electron Microscopy Data Bank (EMDB): 80S ribosome (EMDB: EMD-51847), nucleosome (EMDB: EMD-19906), PSII (EMDB: EMD-51731), Rubisco (EMDB: EMD-51848), microtubule (EMDB: EMD-51804), clathrin (EMDB: EMD-51789), and ATP synthase (EMDB: EMD-51802). Segmentations shown in Figures 2 and 3 are deposited on Zenodo (https://doi.org/10.5281/zenodo.15875785). Particle positions and orientations used for STA, along with all resources derived from this work, are available on GitHub (https://github.com/Chromatin-Structure-Rhythms-Lab/ChlamyAnnotations). Reconstructed tomograms and annotations are also available to explore interactively at the CZII Cryo-ET Data Portal (DS-10302, https://cryoetdataportal.czscience.com/datasets/10302/). Raw data for cryo-PFIB/SEM slice-and-view of a whole C. reinhardtii cell has also been deposited (EMPIAR: EMPIAR-11275).\r\n\r\nThis paper does not report original code.\r\n\r\nAny additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.","OA_type":"hybrid","scopus_import":"1","date_updated":"2026-10-20T09:02:52Z","author":[{"full_name":"Kelley, Ron","last_name":"Kelley","first_name":"Ron"},{"full_name":"Khavnekar, Sagar","first_name":"Sagar","last_name":"Khavnekar"},{"full_name":"Righetto, Ricardo D.","last_name":"Righetto","first_name":"Ricardo D."},{"full_name":"Heebner, Jessica","last_name":"Heebner","first_name":"Jessica"},{"orcid":"0000-0003-1756-6564","last_name":"Obr","first_name":"Martin","full_name":"Obr, Martin","id":"4741CA5A-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Xianjun","last_name":"Zhang","full_name":"Zhang, Xianjun"},{"full_name":"Chakraborty, Saikat","last_name":"Chakraborty","first_name":"Saikat"},{"first_name":"Grigory","last_name":"Tagiltsev","full_name":"Tagiltsev, Grigory"},{"orcid":"0000-0002-6080-839X","full_name":"Michael, Alicia","id":"6437c950-2a03-11ee-914d-d6476dd7b75c","last_name":"Michael","first_name":"Alicia"},{"full_name":"Van Dorst, Sofie","last_name":"Van Dorst","first_name":"Sofie"},{"full_name":"Waltz, Florent","first_name":"Florent","last_name":"Waltz"},{"last_name":"Mccafferty","first_name":"Caitlyn L.","full_name":"Mccafferty, Caitlyn L."},{"full_name":"Lamm, Lorenz","last_name":"Lamm","first_name":"Lorenz"},{"full_name":"Zufferey, Simon","last_name":"Zufferey","first_name":"Simon"},{"full_name":"Van Der Stappen, Philippe","last_name":"Van Der Stappen","first_name":"Philippe"},{"full_name":"Van Den Hoek, Hugo","last_name":"Van Den Hoek","first_name":"Hugo"},{"full_name":"Wietrzynski, Wojciech","first_name":"Wojciech","last_name":"Wietrzynski"},{"first_name":"Pavol","last_name":"Harar","id":"e03d953a-6e8c-11ef-99e4-f0717d385cd5","full_name":"Harar, Pavol","orcid":"0000-0001-5206-1794"},{"first_name":"William","last_name":"Wan","full_name":"Wan, William"},{"full_name":"Briggs, John A.G.","first_name":"John A.G.","last_name":"Briggs"},{"full_name":"Plitzko, Jürgen M.","first_name":"Jürgen M.","last_name":"Plitzko"},{"full_name":"Engel, Benjamin D.","last_name":"Engel","first_name":"Benjamin D."},{"last_name":"Kotecha","first_name":"Abhay","full_name":"Kotecha, Abhay"}],"language":[{"iso":"eng"}],"abstract":[{"text":"In situ cryo-electron tomography (cryo-ET) has emerged as the method of choice to investigate the structures of biomolecules in their native context. However, challenges remain for the efficient production and sharing of large-scale cryo-ET datasets. Here, we combined cryogenic plasma-based focused ion beam (cryo-PFIB) milling with recent advances in cryo-ET acquisition and processing to generate a dataset of 1,829 annotated tomograms of the green alga Chlamydomonas reinhardtii, which we provide as a community resource to drive method development and inspire biological discovery. To assay data quality, we performed subtomogram averaging of both soluble and membrane-bound complexes ranging in size from >3 MDa to ∼200 kDa, including 80S ribosomes, Rubisco, nucleosomes, microtubules, clathrin, photosystem II, and mitochondrial ATP synthase. The majority of these density maps reached sub-nanometer resolution, demonstrating the potential of this C. reinhardtii dataset as well as the promise of modern cryo-ET workflows and open data sharing to empower visual proteomics.","lang":"eng"}],"OA_place":"publisher","type":"journal_article","status":"public","quality_controlled":"1","PlanS_conform":"1","citation":{"apa":"Kelley, R., Khavnekar, S., Righetto, R. D., Heebner, J., Obr, M., Zhang, X., … Kotecha, A. (2026). Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii. Molecular Cell. Cell Press. https://doi.org/10.1016/j.molcel.2025.11.029","mla":"Kelley, Ron, et al. “Toward Community-Driven Visual Proteomics with Large-Scale Cryo-Electron Tomography of Chlamydomonas Reinhardtii.” Molecular Cell, vol. 86, no. 1, Cell Press, 2026, p. 213–230.e7, doi:10.1016/j.molcel.2025.11.029.","chicago":"Kelley, Ron, Sagar Khavnekar, Ricardo D. Righetto, Jessica Heebner, Martin Obr, Xianjun Zhang, Saikat Chakraborty, et al. “Toward Community-Driven Visual Proteomics with Large-Scale Cryo-Electron Tomography of Chlamydomonas Reinhardtii.” Molecular Cell. Cell Press, 2026. https://doi.org/10.1016/j.molcel.2025.11.029.","short":"R. Kelley, S. Khavnekar, R.D. Righetto, J. Heebner, M. Obr, X. Zhang, S. Chakraborty, G. Tagiltsev, A.K. Michael, S. Van Dorst, F. Waltz, C.L. Mccafferty, L. Lamm, S. Zufferey, P. Van Der Stappen, H. Van Den Hoek, W. Wietrzynski, P. Harar, W. Wan, J.A.G. Briggs, J.M. Plitzko, B.D. Engel, A. Kotecha, Molecular Cell 86 (2026) 213–230.e7.","ama":"Kelley R, Khavnekar S, Righetto RD, et al. Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii. Molecular Cell. 2026;86(1):213-230.e7. doi:10.1016/j.molcel.2025.11.029","ieee":"R. Kelley et al., “Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii,” Molecular Cell, vol. 86, no. 1. Cell Press, p. 213–230.e7, 2026.","ista":"Kelley R, Khavnekar S, Righetto RD, Heebner J, Obr M, Zhang X, Chakraborty S, Tagiltsev G, Michael AK, Van Dorst S, Waltz F, Mccafferty CL, Lamm L, Zufferey S, Van Der Stappen P, Van Den Hoek H, Wietrzynski W, Harar P, Wan W, Briggs JAG, Plitzko JM, Engel BD, Kotecha A. 2026. Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii. Molecular Cell. 86(1), 213–230.e7."},"oa_version":"Published Version","date_published":"2026-01-08T00:00:00Z","publisher":"Cell Press","month":"01","ddc":["570"],"file_date_updated":"2026-07-28T07:38:45Z","intvolume":" 86","acknowledgement":"Calculations were performed at the Max Planck Institute of Biochemistry and the Raven Supercomputer of the Max Planck Computing and Data Facility (MPCDF) in Garching, Germany; at the sciCORE (http://scicore.unibas.ch/) scientific computing center at the University of Basel, Switzerland; and at Thermo Fisher Scientific, in Eindhoven, the Netherlands. This work was supported by Thermo Fisher Scientific. All lamella preparations and tilt-series collections used in this work were conducted at Thermo Fisher R&D facilities in Brno and Eindhoven, utilizing Arctis and Krios microscopes. This work was also supported by the ERC consolidator grant “cryOcean” (fulfilled by the Swiss State Secretariat for Education, Research and Innovation, M822.00045) as well as a Swiss Nanoscience Institute PhD school grant to B.D.E. and P.V.d.S., an EMBO long-term postdoctoral fellowship (ALTF-383-2022) to G.T., an SNSF Postdoctoral Fellowship (project 210561) to F.W., a Boehringer Ingelheim Fonds fellowship to L.L., and by the Max Planck Society to J.A.G.B. and J.M.P.","publication_status":"published","year":"2026","date_created":"2026-01-04T23:01:36Z","publication":"Molecular Cell"},{"citation":{"short":"J.S. Calderon Garcia, G. Costalunga, T.P. Vogels, D. Vallentin, Current Biology 36 (2026) 791–798.e6.","apa":"Calderon Garcia, J. S., Costalunga, G., Vogels, T. P., & Vallentin, D. (2026). Interplay between syllable duration and pitch during whistle matching in wild nightingales. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2025.12.025","mla":"Calderon Garcia, Juan Sebastian, et al. “Interplay between Syllable Duration and Pitch during Whistle Matching in Wild Nightingales.” Current Biology, vol. 36, no. 3, Cell Press, 2026, p. 791–798.e6, doi:10.1016/j.cub.2025.12.025.","chicago":"Calderon Garcia, Juan Sebastian, Giacomo Costalunga, Tim P Vogels, and Daniela Vallentin. “Interplay between Syllable Duration and Pitch during Whistle Matching in Wild Nightingales.” Current Biology. Cell Press, 2026. https://doi.org/10.1016/j.cub.2025.12.025.","ama":"Calderon Garcia JS, Costalunga G, Vogels TP, Vallentin D. Interplay between syllable duration and pitch during whistle matching in wild nightingales. Current Biology. 2026;36(3):791-798.e6. doi:10.1016/j.cub.2025.12.025","ista":"Calderon Garcia JS, Costalunga G, Vogels TP, Vallentin D. 2026. Interplay between syllable duration and pitch during whistle matching in wild nightingales. Current Biology. 36(3), 791–798.e6.","ieee":"J. S. Calderon Garcia, G. Costalunga, T. P. Vogels, and D. Vallentin, “Interplay between syllable duration and pitch during whistle matching in wild nightingales,” Current Biology, vol. 36, no. 3. Cell Press, p. 791–798.e6, 2026."},"oa_version":"Published Version","month":"02","ddc":["570","577"],"publisher":"Cell Press","pmid":1,"date_published":"2026-02-02T00:00:00Z","acknowledgement":"We would like to thank J. Benichov and N. Hein for their help with fieldwork; M. Ramadas for helping with the segmentation analysis; T. Eliav, C. Chintaluri, G. Tkacik, and A. Navas for providing helpful comments to the project and manuscript; and A. Costalunga for the drawings of nightingales. Funding sources: The Joachim Herz Stiftung Add-on Fellowships for Interdisciplinary Life Science, awarded to G.C.; the ERC Consolidator Grant 819603 SYNAPSEEK, awarded to T.P.V.; and DFG Research Unit 5768–532521431, DFG Research Grant-547921981, DFG SFB 1315–327654276, and the ERC Starting Grant 757459 MIDNIGHT, awarded to D.V.","intvolume":" 36","file_date_updated":"2026-07-27T10:47:55Z","publication":"Current Biology","date_created":"2026-01-14T12:00:29Z","year":"2026","publication_status":"published","date_updated":"2026-10-20T09:02:18Z","dataavailabilitystatement":"All data have been deposited at https://github.com/vallentinlab/NG-whistle-durations and are publicly available as of the date of publication.\r\nAll original code has been deposited at https://github.com/vallentinlab/NG-whistle-durations and is publicly available as of the date of publication.\r\nAny additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.","OA_type":"hybrid","scopus_import":"1","author":[{"first_name":"Juan Sebastian","last_name":"Calderon Garcia","id":"1271b54b-dbcd-11ea-9d1d-d92da838fe2c","full_name":"Calderon Garcia, Juan Sebastian"},{"first_name":"Giacomo","last_name":"Costalunga","full_name":"Costalunga, Giacomo"},{"last_name":"Vogels","first_name":"Tim P","full_name":"Vogels, Tim P","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","orcid":"0000-0003-3295-6181"},{"first_name":"Daniela","last_name":"Vallentin","full_name":"Vallentin, Daniela"}],"type":"journal_article","OA_place":"publisher","abstract":[{"lang":"eng","text":"During complex vocal interactions, different features of acoustic stimuli are integrated to produce appropriate vocal responses,1 such as copying sounds during vocal matching behavior in some animals.2,3,4,5,6,7,8,9,10,11,12 However, little is known about the interplay and possible trade-offs between the different temporal and spectral acoustic features during these vocal exchanges.2,13,14 Nightingales can flexibly match the pitch of their tonal “whistle songs” in real time during counter-singing duels.15,16 Here, we show that the syllable duration of whistle playbacks could alter the song responses of wild nightingales, causing their whistle duration distribution to shift toward the presented stimulus duration. When exposed to whistle playbacks featuring unnatural combinations of pitch and duration, nightingales demonstrate a flexible trade-off between pitch matching and temporal imitation, yet they are constrained by their vocal repertoire. They selectively adapted their vocal responses to approximate these novel stimuli, aligning them with their natural whistle repertoire. We developed a computational model of nightingale whistle-matching behavior that revealed a hierarchical organization of acoustic feature production. During whistle matching, the feature integration process is constrained by the duration of syllables, and pitch matching follows within this temporal framework, forcing a trade-off between the two features. Our findings reveal a complex interplay between the spectral and temporal domains that shapes song-matching behavior."}],"language":[{"iso":"eng"}],"PlanS_conform":"1","quality_controlled":"1","status":"public","has_accepted_license":"1","volume":36,"article_type":"original","external_id":{"pmid":["41529680"]},"das_tickbox":"1","article_processing_charge":"Yes (in subscription journal)","issue":"3","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"file":[{"date_updated":"2026-07-27T10:47:55Z","relation":"main_file","success":1,"access_level":"open_access","checksum":"e17c3537193d5ab4886596d1a04f9b0e","creator":"dernst","file_size":7120959,"file_name":"2026_CurrentBiology_CalderonGarcia.pdf","file_id":"22416","date_created":"2026-07-27T10:47:55Z","content_type":"application/pdf"}],"researchdata_availability":"yes","project":[{"call_identifier":"H2020","grant_number":"819603","name":"Learning the shape of synaptic plasticity rules for neuronal architectures and function through machine learning.","_id":"0aacfa84-070f-11eb-9043-d7eb2c709234"}],"doi":"10.1016/j.cub.2025.12.025","oa":1,"department":[{"_id":"GradSch"},{"_id":"TiVo"}],"fulldoi":"https://doi.org/10.1016/j.cub.2025.12.025","supplementarymaterial":"yes","page":"791-798.e6","publication_identifier":{"eissn":["1879-0445"],"issn":["0960-9822"]},"day":"02","_id":"20986","title":"Interplay between syllable duration and pitch during whistle matching in wild nightingales","ec_funded":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"das_tickbox":"1","article_type":"original","external_id":{"pmid":["41890976"]},"article_processing_charge":"Yes","has_accepted_license":"1","volume":29,"researchdata_availability":"upon request","file":[{"file_size":14469960,"file_name":"2026_iScience_Akther.pdf","creator":"dernst","checksum":"9c9ccc87072d04808e4af407d647ed20","content_type":"application/pdf","date_created":"2026-07-27T12:03:23Z","file_id":"22427","success":1,"date_updated":"2026-07-27T12:03:23Z","relation":"main_file","access_level":"open_access"}],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"doi":"10.1016/j.isci.2026.115192","oa":1,"issue":"4","publication_identifier":{"eissn":["2589-0042"]},"day":"17","department":[{"_id":"RySh"}],"fulldoi":"https://doi.org/10.1016/j.isci.2026.115192","supplementarymaterial":"no","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"21502","title":"Distribution and functional significance of rodent cerebellar glycogen","publisher":"Cell Press","month":"04","ddc":["570"],"date_published":"2026-04-17T00:00:00Z","pmid":1,"citation":{"apa":"Akther, S., Lee, A. B., Konno, A., Asiminas, A., Vittani, M., Mishima, T., … Hirase, H. (2026). Distribution and functional significance of rodent cerebellar glycogen. IScience. Cell Press. https://doi.org/10.1016/j.isci.2026.115192","chicago":"Akther, Sonam, Ashley Bomin Lee, Ayumu Konno, Antonis Asiminas, Marta Vittani, Tsuneko Mishima, Hirokazu Hirai, et al. “Distribution and Functional Significance of Rodent Cerebellar Glycogen.” IScience. Cell Press, 2026. https://doi.org/10.1016/j.isci.2026.115192.","mla":"Akther, Sonam, et al. “Distribution and Functional Significance of Rodent Cerebellar Glycogen.” IScience, vol. 29, no. 4, 115192, Cell Press, 2026, doi:10.1016/j.isci.2026.115192.","short":"S. Akther, A.B. Lee, A. Konno, A. Asiminas, M. Vittani, T. Mishima, H. Hirai, C.F. Meehan, J. Duran, J. Guinovart, H. Ashida, T. Morita, O. Baba, R. Shigemoto, M. Nedergaard, H. Hirase, IScience 29 (2026).","ama":"Akther S, Lee AB, Konno A, et al. Distribution and functional significance of rodent cerebellar glycogen. iScience. 2026;29(4). doi:10.1016/j.isci.2026.115192","ieee":"S. Akther et al., “Distribution and functional significance of rodent cerebellar glycogen,” iScience, vol. 29, no. 4. Cell Press, 2026.","ista":"Akther S, Lee AB, Konno A, Asiminas A, Vittani M, Mishima T, Hirai H, Meehan CF, Duran J, Guinovart J, Ashida H, Morita T, Baba O, Shigemoto R, Nedergaard M, Hirase H. 2026. Distribution and functional significance of rodent cerebellar glycogen. iScience. 29(4), 115192."},"oa_version":"Published Version","publication_status":"published","publication":"iScience","date_created":"2026-03-29T22:07:07Z","year":"2026","intvolume":" 29","article_number":"115192","acknowledgement":"This work was supported by the Novo Nordisk Foundation (NNFOC0058058, H. Hirase), the Danmarks Frie Forskningsfond (0134-00107B and 5283-00069A, H.Hirase), the Lundbeck Foundation, Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) program (22K06454/24H01221, A.K.; 23K27482, H.Hirai), the Japan Agency for Medical Research and Development (AMED) Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) (JP21dm0207111, H. Hirai), AMED Brain/MINDS 2.0 (JP23wm0625001 and JP24wm0625103, H. Hirai), and grants from the Spanish Ministerio de Ciencia e Innovación (MCIU/FEDER/AEI) (PID2020-118699 GB-100, J.D.) and the Fundación Ramón Areces (J.D.). Sonam Akther has been supported by the RIKEN IPA fellowship. We are thankful to Dr. Yuki Oe for his support in the initial stage of this study and to Dan Xue for his help with the graphical abstract. We thank Dr. Pia Weikop for providing CTN research infrastructure. The authors declare no competing financial interests.","file_date_updated":"2026-07-27T12:03:23Z","author":[{"last_name":"Akther","first_name":"Sonam","full_name":"Akther, Sonam"},{"last_name":"Lee","first_name":"Ashley Bomin","full_name":"Lee, Ashley Bomin"},{"last_name":"Konno","first_name":"Ayumu","full_name":"Konno, Ayumu"},{"first_name":"Antonis","last_name":"Asiminas","full_name":"Asiminas, Antonis"},{"last_name":"Vittani","first_name":"Marta","full_name":"Vittani, Marta"},{"full_name":"Mishima, Tsuneko","first_name":"Tsuneko","last_name":"Mishima"},{"full_name":"Hirai, Hirokazu","last_name":"Hirai","first_name":"Hirokazu"},{"first_name":"Claire Francesca","last_name":"Meehan","full_name":"Meehan, Claire Francesca"},{"first_name":"Jordi","last_name":"Duran","full_name":"Duran, Jordi"},{"last_name":"Guinovart","first_name":"Joan","full_name":"Guinovart, Joan"},{"last_name":"Ashida","first_name":"Hitoshi","full_name":"Ashida, Hitoshi"},{"first_name":"Tsuyoshi","last_name":"Morita","full_name":"Morita, Tsuyoshi"},{"first_name":"Otto","last_name":"Baba","full_name":"Baba, Otto"},{"orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Maiken","last_name":"Nedergaard","full_name":"Nedergaard, Maiken"},{"first_name":"Hajime","last_name":"Hirase","full_name":"Hirase, Hajime"}],"DOAJ_listed":"1","dataavailabilitystatement":"This study did not generate new materials or reagents.All data supporting the findings of this study are available from the lead contact upon reasonable request.\r\nThis study did not generate any new code.\r\nAdditional raw data can be obtained from the lead contact upon reasonable request.","OA_type":"gold","scopus_import":"1","date_updated":"2026-10-20T09:02:33Z","quality_controlled":"1","status":"public","PlanS_conform":"1","OA_place":"publisher","type":"journal_article","language":[{"iso":"eng"}],"abstract":[{"text":"The mammalian brain stores glucose, the main circulating energy substrate, as glycogen. In rodents, the cerebellum contains relatively high glycogen levels, yet its cellular and subcellular distribution remains poorly defined. Using monoclonal antibodies against glycogen, we examined its distribution in the mouse cerebellar cortex. Glycogen was predominantly localized to Bergmann glia (BG) processes in the molecular layer and was also detected in Purkinje cells (PCs), the principal cerebellar neurons. To assess the functional significance of cerebellar glycogen, we analyzed behavior in mice lacking glycogen synthase 1 (Gys1) in BG or PCs using a floxed Gys1 line. Gys1 deficiency in either PCs or GFAP-positive cells reduced anxiety-like behavior, whereas combined deletion caused PC degeneration and ataxia. These findings reveal a critical role for glycogen metabolism in both astrocytes and neurons in cerebellar function.","lang":"eng"}]},{"intvolume":" 7","article_number":"104295","acknowledgement":"We thank R.H. Kim, A. Casper, and R. Gautsch for sequencing at the NGS facility (RRID:SCR_025746). K.T. is an Honorary Professor at the Department of Biology, Ludwig-Maximilians-University, Munich, Germany. This study was funded by European Research Council grant ERC-CoG-818556 TotipotentZygotChrom (K.T.), Max Planck Society (K.T.), and ERC Starting Grant “ChromaChrono” 101162145 (A.K.M.).","file_date_updated":"2026-07-23T06:33:24Z","publication_status":"published","year":"2026","date_created":"2026-01-04T23:01:33Z","publication":"STAR Protocols","oa_version":"Published Version","citation":{"short":"W. Kobayashi, A.K. Michael, S. Ruangroengkulrith, M. Kümmecke, K. Tachibana, STAR Protocols 7 (2026).","apa":"Kobayashi, W., Michael, A. K., Ruangroengkulrith, S., Kümmecke, M., & Tachibana, K. (2026). Protocol for integrative analysis of transcription factor-nucleosome interactions using SeEN-seq and cryo-EM structure determination. STAR Protocols. Cell Press. https://doi.org/10.1016/j.xpro.2025.104295","mla":"Kobayashi, Wataru, et al. “Protocol for Integrative Analysis of Transcription Factor-Nucleosome Interactions Using SeEN-Seq and Cryo-EM Structure Determination.” STAR Protocols, vol. 7, no. 1, 104295, Cell Press, 2026, doi:10.1016/j.xpro.2025.104295.","chicago":"Kobayashi, Wataru, Alicia K. Michael, Siwat Ruangroengkulrith, Maximilian Kümmecke, and Kikuë Tachibana. “Protocol for Integrative Analysis of Transcription Factor-Nucleosome Interactions Using SeEN-Seq and Cryo-EM Structure Determination.” STAR Protocols. Cell Press, 2026. https://doi.org/10.1016/j.xpro.2025.104295.","ama":"Kobayashi W, Michael AK, Ruangroengkulrith S, Kümmecke M, Tachibana K. Protocol for integrative analysis of transcription factor-nucleosome interactions using SeEN-seq and cryo-EM structure determination. STAR Protocols. 2026;7(1). doi:10.1016/j.xpro.2025.104295","ista":"Kobayashi W, Michael AK, Ruangroengkulrith S, Kümmecke M, Tachibana K. 2026. Protocol for integrative analysis of transcription factor-nucleosome interactions using SeEN-seq and cryo-EM structure determination. STAR Protocols. 7(1), 104295.","ieee":"W. Kobayashi, A. K. Michael, S. Ruangroengkulrith, M. Kümmecke, and K. Tachibana, “Protocol for integrative analysis of transcription factor-nucleosome interactions using SeEN-seq and cryo-EM structure determination,” STAR Protocols, vol. 7, no. 1. Cell Press, 2026."},"publisher":"Cell Press","month":"03","ddc":["570"],"date_published":"2026-03-20T00:00:00Z","pmid":1,"OA_place":"publisher","type":"journal_article","language":[{"iso":"eng"}],"abstract":[{"text":"Pioneer transcription factors (TFs) possess the ability to read out DNA motifs embedded within nucleosomes, driving changes in gene expression during cellular differentiation and reprogramming. Here, we present selected engagement on nucleosome sequencing (SeEN-seq), a protocol designed to systematically identify potential TF-binding sites on the nucleosome. We describe steps for nucleosome library assembly, SeEN-seq assay, and cryoelectron microscopy (cryo-EM) sample preparation. This protocol facilitates the preparation of homogeneous pioneer TF-nucleosome complexes for cryo-EM structure determination using single-particle analysis.\r\nFor complete details on the use and execution of this protocol, please refer to Michael et al.1","lang":"eng"}],"status":"public","quality_controlled":"1","PlanS_conform":"1","OA_type":"gold","scopus_import":"1","dataavailabilitystatement":"Raw SeEN-seq data of ESRRB nucleosome binding have been deposited on the Sequence Read Achieve database under the accession PRJNA1305216. Example analysis scripts and input files for SeEN-seq analysis can be found at https://doi.org/10.5281/zenodo.17665082.","date_updated":"2026-10-20T09:01:26Z","author":[{"full_name":"Kobayashi, Wataru","last_name":"Kobayashi","first_name":"Wataru"},{"orcid":"0000-0002-6080-839X","first_name":"Alicia","last_name":"Michael","id":"6437c950-2a03-11ee-914d-d6476dd7b75c","full_name":"Michael, Alicia"},{"last_name":"Ruangroengkulrith","first_name":"Siwat","full_name":"Ruangroengkulrith, Siwat"},{"full_name":"Kümmecke, Maximilian","last_name":"Kümmecke","first_name":"Maximilian"},{"full_name":"Tachibana, Kikuë","first_name":"Kikuë","last_name":"Tachibana"}],"DOAJ_listed":"1","issue":"1","corr_author":"1","researchdata_availability":"yes","file":[{"success":1,"date_updated":"2026-07-23T06:33:24Z","relation":"main_file","access_level":"open_access","file_name":"2026_StarProtocols_Kobayashi.pdf","file_size":5531906,"creator":"dernst","checksum":"cf04b061a48548a649e6a2435bf120db","content_type":"application/pdf","date_created":"2026-07-23T06:33:24Z","file_id":"22389"}],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"project":[{"grant_number":"101162145","name":"Circadian structural transitions of chromatin","_id":"9136c684-16d5-11f0-9cad-91c0177b365f"}],"doi":"10.1016/j.xpro.2025.104295","oa":1,"volume":7,"has_accepted_license":"1","das_tickbox":"1","external_id":{"pmid":["41455105"]},"article_type":"original","article_processing_charge":"Yes","_id":"20924","title":"Protocol for integrative analysis of transcription factor-nucleosome interactions using SeEN-seq and cryo-EM structure determination","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"AlMi"}],"supplementarymaterial":"yes","fulldoi":"https://doi.org/10.1016/j.xpro.2025.104295","day":"20","publication_identifier":{"eissn":["2666-1667"]}},{"intvolume":" 31","acknowledgement":"I apologize to colleagues whose relevant work I was unable to cite due to space limitations. This work was funded by the European Union (ERC, CYNIPS, 101142681) and Austrian Science Fund (FWF; 37051-B). I thank Drs Huihuang Chen, Yuanrong Pei, Jason Reed, Linlin Qi, and Dolf Weijers for inspiration and critical input.","file_date_updated":"2026-07-27T08:26:40Z","publication_status":"published","publication":"Trends in Plant Science","date_created":"2025-12-02T16:29:22Z","year":"2026","oa_version":"Published Version","citation":{"ieee":"J. Friml, “Role of cAMP in TIR1/AFB auxin signaling: Open issues,” Trends in Plant Science, vol. 31, no. 2. Cell Press, pp. 136–138, 2026.","ista":"Friml J. 2026. Role of cAMP in TIR1/AFB auxin signaling: Open issues. Trends in Plant Science. 31(2), 136–138.","ama":"Friml J. Role of cAMP in TIR1/AFB auxin signaling: Open issues. Trends in Plant Science. 2026;31(2):136-138. doi:10.1016/j.tplants.2025.10.018","short":"J. Friml, Trends in Plant Science 31 (2026) 136–138.","mla":"Friml, Jiří. “Role of CAMP in TIR1/AFB Auxin Signaling: Open Issues.” Trends in Plant Science, vol. 31, no. 2, Cell Press, 2026, pp. 136–38, doi:10.1016/j.tplants.2025.10.018.","chicago":"Friml, Jiří. “Role of CAMP in TIR1/AFB Auxin Signaling: Open Issues.” Trends in Plant Science. Cell Press, 2026. https://doi.org/10.1016/j.tplants.2025.10.018.","apa":"Friml, J. (2026). Role of cAMP in TIR1/AFB auxin signaling: Open issues. Trends in Plant Science. Cell Press. https://doi.org/10.1016/j.tplants.2025.10.018"},"publisher":"Cell Press","month":"02","ddc":["580"],"date_published":"2026-02-01T00:00:00Z","pmid":1,"OA_place":"publisher","type":"journal_article","language":[{"iso":"eng"}],"abstract":[{"text":"The canonical mechanism by which the phytohormone auxin regulates transcription has been one of the cornerstones of plant signaling. The recent unexpected discovery of cyclic AMP (cAMP) as a second messenger in this pathway has revised its foundations while leaving many open questions and gaps in our understanding; these will be discussed in this forum article.","lang":"eng"}],"status":"public","quality_controlled":"1","PlanS_conform":"1","OA_type":"hybrid","scopus_import":"1","date_updated":"2026-10-20T09:01:46Z","author":[{"last_name":"Friml","first_name":"Jiří","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596"}],"issue":"2","corr_author":"1","researchdata_availability":"no","file":[{"checksum":"e60e903fb4b3e917dba763976ec652cd","creator":"dernst","file_size":432792,"file_name":"2026_TrendsPlantScience_Friml.pdf","file_id":"22413","date_created":"2026-07-27T08:26:40Z","content_type":"application/pdf","relation":"main_file","date_updated":"2026-07-27T08:26:40Z","success":1,"access_level":"open_access"}],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"oa":1,"doi":"10.1016/j.tplants.2025.10.018","project":[{"_id":"8f347782-16d5-11f0-9cad-8c19706ee739","name":"Cyclic nucleotides as second messengers in plants","grant_number":"101142681"},{"grant_number":"P37051","name":"Guanylate cyclase activity of TIR1/AFBs auxin receptors","_id":"7bcece63-9f16-11ee-852c-ae94e099eeb6"}],"volume":31,"has_accepted_license":"1","das_tickbox":"0","external_id":{"pmid":["41249070"]},"article_type":"review","article_processing_charge":"Yes (via OA deal)","_id":"20725","title":"Role of cAMP in TIR1/AFB auxin signaling: Open issues","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"JiFr"}],"fulldoi":"https://doi.org/10.1016/j.tplants.2025.10.018","supplementarymaterial":"no","publication_identifier":{"issn":["1360-1385"],"eissn":["1878-4372"]},"page":"136-138","day":"01"}]