---
_id: '12696'
abstract:
- lang: eng
  text: "Background: Fighting disease while fighting rivals exposes males to constraints
    and tradeoffs during male-male competition. We here tested how both the stage
    and intensity of infection with the fungal pathogen Metarhizium robertsii interfered
    with fighting success in Cardiocondyla obscurior ant males. Males of this species
    have evolved long lifespans during which they can gain many matings with the young
    queens of the colony, if successful in male-male competition. Since male fights
    occur inside the colony, the outcome of male-male competition can further be biased
    by interference of the colony’s worker force.\r\nResults: We found that severe,
    but not yet mild, infection strongly impaired male fighting success. In late-stage
    infection, this could be attributed to worker aggression directed towards the
    infected rather than the healthy male and an already very high male morbidity
    even in the absence of fighting. Shortly after pathogen exposure, however, male
    mortality was particularly increased during combat. Since these males mounted
    a strong immune response, their reduced fighting success suggests a trade-off
    between immune investment and competitive ability already early in the infection.
    Even if the males themselves showed no difference in the number of attacks they
    raised against their healthy rivals across infection stages and levels, severely
    infected males were thus losing in male-male competition from an early stage of
    infection on.\r\nConclusions: Males of the ant C. obscurior have evolved high
    immune investment, triggering an effective immune response very fast after fungal
    exposure. This allows them to cope with mild pathogen exposures without cost to
    their success in male-male competition, and hence to gain multiple mating opportunities
    with the emerging virgin queens of the colony. Under severe infection, however,
    they are weak fighters and rarely survive a combat already at early infection
    when raising an immune response, as well as at progressed infection, when they
    are morbid and preferentially targeted by worker aggression. Workers thereby remove
    males that pose a future disease threat by biasing male-male competition. Our
    study thus revealed a novel social immunity mechanism how social insect workers
    protect the colony against disease risk."
acknowledged_ssus:
- _id: LifeSc
acknowledgement: "We are thankful to Mike Bidochka for the fungal strain, Lukas Schrader
  for sharing the C. obscurior genome data for primer development, the Lab Support
  Facility of ISTA for general laboratory support and help with the permit approval
  procedures, and the Finca El Quinto for letting us collect ants on their property.
  We thank the Social Immunity Team at ISTA for help with ant collection and experimental
  help, in particular Elina Hanhimäki and Marta Gorecka for behavioural observation,
  and Elisabeth Naderlinger for spore load PCRs. We further thank the Social Immunity
  Team and Jürgen Heinze for continued discussion and comments on the manuscript.\r\nOpen
  access funding provided by Institute of Science and Technology Austria (ISTA). This
  project received funding from the European Research Council (ERC) under the European
  Union’s Horizon 2020 research and innovation programme (grant agreement No 771402
  to SC). "
article_number: '37'
article_processing_charge: Yes
article_type: original
author:
- first_name: Sina
  full_name: Metzler, Sina
  id: 48204546-F248-11E8-B48F-1D18A9856A87
  last_name: Metzler
  orcid: 0000-0002-9547-2494
- first_name: Jessica
  full_name: Kirchner, Jessica
  id: 21516227-15aa-11ec-9fb2-c6e8ffc155d3
  last_name: Kirchner
- first_name: Anna V
  full_name: Grasse, Anna V
  id: 406F989C-F248-11E8-B48F-1D18A9856A87
  last_name: Grasse
- first_name: Sylvia
  full_name: Cremer, Sylvia
  id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
  last_name: Cremer
  orcid: 0000-0002-2193-3868
citation:
  ama: Metzler S, Kirchner J, Grasse AV, Cremer S. Trade-offs between immunity and
    competitive ability in fighting ant males. <i>BMC Ecology and Evolution</i>. 2023;23.
    doi:<a href="https://doi.org/10.1186/s12862-023-02137-7">10.1186/s12862-023-02137-7</a>
  apa: Metzler, S., Kirchner, J., Grasse, A. V., &#38; Cremer, S. (2023). Trade-offs
    between immunity and competitive ability in fighting ant males. <i>BMC Ecology
    and Evolution</i>. Springer Nature. <a href="https://doi.org/10.1186/s12862-023-02137-7">https://doi.org/10.1186/s12862-023-02137-7</a>
  chicago: Metzler, Sina, Jessica Kirchner, Anna V Grasse, and Sylvia Cremer. “Trade-Offs
    between Immunity and Competitive Ability in Fighting Ant Males.” <i>BMC Ecology
    and Evolution</i>. Springer Nature, 2023. <a href="https://doi.org/10.1186/s12862-023-02137-7">https://doi.org/10.1186/s12862-023-02137-7</a>.
  ieee: S. Metzler, J. Kirchner, A. V. Grasse, and S. Cremer, “Trade-offs between
    immunity and competitive ability in fighting ant males,” <i>BMC Ecology and Evolution</i>,
    vol. 23. Springer Nature, 2023.
  ista: Metzler S, Kirchner J, Grasse AV, Cremer S. 2023. Trade-offs between immunity
    and competitive ability in fighting ant males. BMC Ecology and Evolution. 23,
    37.
  mla: Metzler, Sina, et al. “Trade-Offs between Immunity and Competitive Ability
    in Fighting Ant Males.” <i>BMC Ecology and Evolution</i>, vol. 23, 37, Springer
    Nature, 2023, doi:<a href="https://doi.org/10.1186/s12862-023-02137-7">10.1186/s12862-023-02137-7</a>.
  short: S. Metzler, J. Kirchner, A.V. Grasse, S. Cremer, BMC Ecology and Evolution
    23 (2023).
corr_author: '1'
date_created: 2023-02-28T07:38:17Z
date_published: 2023-08-07T00:00:00Z
date_updated: 2025-04-14T07:47:53Z
day: '07'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.1186/s12862-023-02137-7
ec_funded: 1
external_id:
  isi:
  - '001042643600002'
  pmid:
  - '37550612'
file:
- access_level: open_access
  checksum: 95966dc7d242d2c85bdd4fe14233dbd8
  content_type: application/pdf
  creator: dernst
  date_created: 2023-08-14T07:51:47Z
  date_updated: 2023-08-14T07:51:47Z
  file_id: '14048'
  file_name: 2023_BMCEcology_Metzler.pdf
  file_size: 2004276
  relation: main_file
  success: 1
file_date_updated: 2023-08-14T07:51:47Z
has_accepted_license: '1'
intvolume: '        23'
isi: 1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2649B4DE-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '771402'
  name: Epidemics in ant societies on a chip
publication: BMC Ecology and Evolution
publication_identifier:
  issn:
  - 2730-7182
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  record:
  - id: '12693'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Trade-offs between immunity and competitive ability in fighting ant males
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2023'
...
---
_id: '12697'
abstract:
- lang: eng
  text: Models for same-material contact electrification in granular media often rely
    on a local charge-driving parameter whose spatial variations lead to a stochastic
    origin for charge exchange. Measuring the charge transfer from individual granular
    spheres after contacts with substrates of the same material, we find instead a
    “global” charging behavior, coherent over the sample’s whole surface. Cleaning
    and baking samples fully resets charging magnitude and direction, which indicates
    the underlying global parameter is not intrinsic to the material, but acquired
    from its history. Charging behavior is randomly and irreversibly affected by changes
    in relative humidity, hinting at a mechanism where adsorbates, in particular,
    water, are fundamental to the charge-transfer process.
acknowledgement: "We would like to thank Troy Shinbrot, Victor Lee and Daniele Foresti
  for helpful discussions. This project has received funding from the European Research
  Council Grant Agreement No. 949120 and from the the Marie Sk lodowska-Curie Grant
  Agreement No. 754411 under\r\nthe European Union’s Horizon 2020 research and innovation
  program."
article_number: '098202'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Galien M
  full_name: Grosjean, Galien M
  id: 0C5FDA4A-9CF6-11E9-8939-FF05E6697425
  last_name: Grosjean
  orcid: 0000-0001-5154-417X
- first_name: Scott R
  full_name: Waitukaitis, Scott R
  id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87
  last_name: Waitukaitis
  orcid: 0000-0002-2299-3176
citation:
  ama: Grosjean GM, Waitukaitis SR. Single-collision statistics reveal a global mechanism
    driven by sample history for contact electrification in granular media. <i>Physical
    Review Letters</i>. 2023;130(9). doi:<a href="https://doi.org/10.1103/physrevlett.130.098202">10.1103/physrevlett.130.098202</a>
  apa: Grosjean, G. M., &#38; Waitukaitis, S. R. (2023). Single-collision statistics
    reveal a global mechanism driven by sample history for contact electrification
    in granular media. <i>Physical Review Letters</i>. American Physical Society.
    <a href="https://doi.org/10.1103/physrevlett.130.098202">https://doi.org/10.1103/physrevlett.130.098202</a>
  chicago: Grosjean, Galien M, and Scott R Waitukaitis. “Single-Collision Statistics
    Reveal a Global Mechanism Driven by Sample History for Contact Electrification
    in Granular Media.” <i>Physical Review Letters</i>. American Physical Society,
    2023. <a href="https://doi.org/10.1103/physrevlett.130.098202">https://doi.org/10.1103/physrevlett.130.098202</a>.
  ieee: G. M. Grosjean and S. R. Waitukaitis, “Single-collision statistics reveal
    a global mechanism driven by sample history for contact electrification in granular
    media,” <i>Physical Review Letters</i>, vol. 130, no. 9. American Physical Society,
    2023.
  ista: Grosjean GM, Waitukaitis SR. 2023. Single-collision statistics reveal a global
    mechanism driven by sample history for contact electrification in granular media.
    Physical Review Letters. 130(9), 098202.
  mla: Grosjean, Galien M., and Scott R. Waitukaitis. “Single-Collision Statistics
    Reveal a Global Mechanism Driven by Sample History for Contact Electrification
    in Granular Media.” <i>Physical Review Letters</i>, vol. 130, no. 9, 098202, American
    Physical Society, 2023, doi:<a href="https://doi.org/10.1103/physrevlett.130.098202">10.1103/physrevlett.130.098202</a>.
  short: G.M. Grosjean, S.R. Waitukaitis, Physical Review Letters 130 (2023).
corr_author: '1'
date_created: 2023-02-28T12:14:46Z
date_published: 2023-03-03T00:00:00Z
date_updated: 2025-04-23T08:51:13Z
day: '03'
ddc:
- '530'
- '537'
department:
- _id: ScWa
doi: 10.1103/physrevlett.130.098202
ec_funded: 1
external_id:
  arxiv:
  - '2211.02488'
  isi:
  - '000946178200008'
  pmid:
  - '36930925'
file:
- access_level: open_access
  checksum: c4f2f6eea0408811f8f4898e15890355
  content_type: application/pdf
  creator: ggrosjea
  date_created: 2023-02-28T12:20:27Z
  date_updated: 2023-02-28T12:20:27Z
  file_id: '12698'
  file_name: Main_Preprint.pdf
  file_size: 2301864
  relation: main_file
  success: 1
- access_level: open_access
  checksum: 6af6ed6c97a977f923de4162294b43c4
  content_type: application/pdf
  creator: ggrosjea
  date_created: 2023-02-28T12:20:55Z
  date_updated: 2023-02-28T12:20:55Z
  file_id: '12699'
  file_name: Suppl_info.pdf
  file_size: 1138625
  relation: main_file
  success: 1
- access_level: open_access
  checksum: 3f20365fb9515bdba3a111d912c8d8b4
  content_type: video/mp4
  creator: ggrosjea
  date_created: 2023-02-28T12:37:54Z
  date_updated: 2023-02-28T12:37:54Z
  file_id: '12700'
  file_name: Suppl_vid1.mp4
  file_size: 793449
  relation: main_file
  success: 1
- access_level: open_access
  checksum: 90cecacbe0e2f9dea11f91a4ba20c32e
  content_type: video/mp4
  creator: ggrosjea
  date_created: 2023-02-28T12:37:54Z
  date_updated: 2023-02-28T12:37:54Z
  file_id: '12701'
  file_name: Suppl_vid2.mp4
  file_size: 455925
  relation: main_file
  success: 1
file_date_updated: 2023-02-28T12:37:54Z
has_accepted_license: '1'
intvolume: '       130'
isi: 1
issue: '9'
keyword:
- General Physics
- Electrostatics
- Triboelectricity
- Soft Matter
- Acoustic Levitation
- Granular Materials
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2211.02488
month: '03'
oa: 1
oa_version: Preprint
pmid: 1
project:
- _id: 0aa60e99-070f-11eb-9043-a6de6bdc3afa
  call_identifier: H2020
  grant_number: '949120'
  name: 'Tribocharge: a multi-scale approach to an enduring problem in physics'
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: Physical Review Letters
publication_identifier:
  eissn:
  - 1079-7114
  issn:
  - 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
  record:
  - id: '8101'
    relation: research_paper
    status: public
scopus_import: '1'
status: public
title: Single-collision statistics reveal a global mechanism driven by sample history
  for contact electrification in granular media
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 130
year: '2023'
...
---
_id: '12702'
abstract:
- lang: eng
  text: Hydrocarbon mixtures are extremely abundant in the Universe, and diamond formation
    from them can play a crucial role in shaping the interior structure and evolution
    of planets. With first-principles accuracy, we first estimate the melting line
    of diamond, and then reveal the nature of chemical bonding in hydrocarbons at
    extreme conditions. We finally establish the pressure-temperature phase boundary
    where it is thermodynamically possible for diamond to form from hydrocarbon mixtures
    with different atomic fractions of carbon. Notably, here we show a depletion zone
    at pressures above 200 GPa and temperatures below 3000 K-3500 K where diamond
    formation is thermodynamically favorable regardless of the carbon atomic fraction,
    due to a phase separation mechanism. The cooler condition of the interior of Neptune
    compared to Uranus means that the former is much more likely to contain the depletion
    zone. Our findings can help explain the dichotomy of the two ice giants manifested
    by the low luminosity of Uranus, and lead to a better understanding of (exo-)planetary
    formation and evolution.
acknowledgement: BC thanks Daan Frenkel for stimulating discussions. We thank Aleks
  Reinhardt, Daan Frenkel, Marius Millot, Federica Coppari, Rhys Bunting, and Chris
  J. Pickard for critically reading the manuscript and providing useful suggestions.
  BC acknowledges resources provided by the Cambridge Tier-2 system operated by the
  University of Cambridge Research Computing Service funded by EPSRC Tier-2 capital
  grant EP/P020259/1. SH acknowledges support from LDRD 19-ERD-031 and computing support
  from the Lawrence Livermore National Laboratory (LLNL) Institutional Computing Grand
  Challenge program. Lawrence Livermore National Laboratory is operated by Lawrence
  Livermore National Security, LLC, for the U.S. Department of Energy, National Nuclear
  Security Administration under Contract DE-AC52-07NA27344. MB acknowledges support
  by the European Horizon 2020 program within the Marie Skłodowska-Curie actions (xICE
  grant number 894725), funding from the NOMIS foundation and computational resources
  at the North-German Supercomputing Alliance (HLRN) facilities.
article_number: '1104'
article_processing_charge: No
article_type: original
author:
- first_name: Bingqing
  full_name: Cheng, Bingqing
  id: cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9
  last_name: Cheng
  orcid: 0000-0002-3584-9632
- first_name: Sebastien
  full_name: Hamel, Sebastien
  last_name: Hamel
- first_name: Mandy
  full_name: Bethkenhagen, Mandy
  id: 201939f4-803f-11ed-ab7e-d8da4bd1517f
  last_name: Bethkenhagen
  orcid: 0000-0002-1838-2129
citation:
  ama: Cheng B, Hamel S, Bethkenhagen M. Thermodynamics of diamond formation from
    hydrocarbon mixtures in planets. <i>Nature Communications</i>. 2023;14. doi:<a
    href="https://doi.org/10.1038/s41467-023-36841-1">10.1038/s41467-023-36841-1</a>
  apa: Cheng, B., Hamel, S., &#38; Bethkenhagen, M. (2023). Thermodynamics of diamond
    formation from hydrocarbon mixtures in planets. <i>Nature Communications</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41467-023-36841-1">https://doi.org/10.1038/s41467-023-36841-1</a>
  chicago: Cheng, Bingqing, Sebastien Hamel, and Mandy Bethkenhagen. “Thermodynamics
    of Diamond Formation from Hydrocarbon Mixtures in Planets.” <i>Nature Communications</i>.
    Springer Nature, 2023. <a href="https://doi.org/10.1038/s41467-023-36841-1">https://doi.org/10.1038/s41467-023-36841-1</a>.
  ieee: B. Cheng, S. Hamel, and M. Bethkenhagen, “Thermodynamics of diamond formation
    from hydrocarbon mixtures in planets,” <i>Nature Communications</i>, vol. 14.
    Springer Nature, 2023.
  ista: Cheng B, Hamel S, Bethkenhagen M. 2023. Thermodynamics of diamond formation
    from hydrocarbon mixtures in planets. Nature Communications. 14, 1104.
  mla: Cheng, Bingqing, et al. “Thermodynamics of Diamond Formation from Hydrocarbon
    Mixtures in Planets.” <i>Nature Communications</i>, vol. 14, 1104, Springer Nature,
    2023, doi:<a href="https://doi.org/10.1038/s41467-023-36841-1">10.1038/s41467-023-36841-1</a>.
  short: B. Cheng, S. Hamel, M. Bethkenhagen, Nature Communications 14 (2023).
corr_author: '1'
date_created: 2023-03-05T23:01:04Z
date_published: 2023-02-27T00:00:00Z
date_updated: 2025-04-15T07:39:24Z
day: '27'
ddc:
- '540'
department:
- _id: BiCh
doi: 10.1038/s41467-023-36841-1
external_id:
  isi:
  - '000939678300002'
  pmid:
  - '36843123'
file:
- access_level: open_access
  checksum: 5ff61ad21511950c15abb73b18613883
  content_type: application/pdf
  creator: cchlebak
  date_created: 2023-03-07T10:58:00Z
  date_updated: 2023-03-07T10:58:00Z
  file_id: '12713'
  file_name: 2023_NatComm_Cheng.pdf
  file_size: 1946443
  relation: main_file
  success: 1
file_date_updated: 2023-03-07T10:58:00Z
has_accepted_license: '1'
intvolume: '        14'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 9B861AAC-BA93-11EA-9121-9846C619BF3A
  name: NOMIS Fellowship Program
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Thermodynamics of diamond formation from hydrocarbon mixtures in planets
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 14
year: '2023'
...
---
_id: '12704'
abstract:
- lang: eng
  text: Adversarial training (i.e., training on adversarially perturbed input data)
    is a well-studied method for making neural networks robust to potential adversarial
    attacks during inference. However, the improved robustness does not come for free
    but rather is accompanied by a decrease in overall model accuracy and performance.
    Recent work has shown that, in practical robot learning applications, the effects
    of adversarial training do not pose a fair trade-off but inflict a net loss when
    measured in holistic robot performance. This work revisits the robustness-accuracy
    trade-off in robot learning by systematically analyzing if recent advances in
    robust training methods and theory in conjunction with adversarial robot learning,
    are capable of making adversarial training suitable for real-world robot applications.
    We evaluate three different robot learning tasks ranging from autonomous driving
    in a high-fidelity environment amenable to sim-to-real deployment to mobile robot
    navigation and gesture recognition. Our results demonstrate that, while these
    techniques make incremental improvements on the trade-off on a relative scale,
    the negative impact on the nominal accuracy caused by adversarial training still
    outweighs the improved robustness by an order of magnitude. We conclude that although
    progress is happening, further advances in robust learning methods are necessary
    before they can benefit robot learning tasks in practice.
acknowledgement: "We thank Christoph Lampert for inspiring this work. The\r\nviews
  and conclusions contained in this document are those of\r\nthe authors and should
  not be interpreted as representing the\r\nofficial policies, either expressed or
  implied, of the United States\r\nAir Force or the U.S. Government. The U.S. Government
  is\r\nauthorized to reproduce and distribute reprints for Government\r\npurposes
  notwithstanding any copyright notation herein."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Mathias
  full_name: Lechner, Mathias
  id: 3DC22916-F248-11E8-B48F-1D18A9856A87
  last_name: Lechner
- first_name: Alexander
  full_name: Amini, Alexander
  last_name: Amini
- first_name: Daniela
  full_name: Rus, Daniela
  last_name: Rus
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000-0002-2985-7724
citation:
  ama: Lechner M, Amini A, Rus D, Henzinger TA. Revisiting the adversarial robustness-accuracy
    tradeoff in robot learning. <i>IEEE Robotics and Automation Letters</i>. 2023;8(3):1595-1602.
    doi:<a href="https://doi.org/10.1109/LRA.2023.3240930">10.1109/LRA.2023.3240930</a>
  apa: Lechner, M., Amini, A., Rus, D., &#38; Henzinger, T. A. (2023). Revisiting
    the adversarial robustness-accuracy tradeoff in robot learning. <i>IEEE Robotics
    and Automation Letters</i>. Institute of Electrical and Electronics Engineers.
    <a href="https://doi.org/10.1109/LRA.2023.3240930">https://doi.org/10.1109/LRA.2023.3240930</a>
  chicago: Lechner, Mathias, Alexander Amini, Daniela Rus, and Thomas A Henzinger.
    “Revisiting the Adversarial Robustness-Accuracy Tradeoff in Robot Learning.” <i>IEEE
    Robotics and Automation Letters</i>. Institute of Electrical and Electronics Engineers,
    2023. <a href="https://doi.org/10.1109/LRA.2023.3240930">https://doi.org/10.1109/LRA.2023.3240930</a>.
  ieee: M. Lechner, A. Amini, D. Rus, and T. A. Henzinger, “Revisiting the adversarial
    robustness-accuracy tradeoff in robot learning,” <i>IEEE Robotics and Automation
    Letters</i>, vol. 8, no. 3. Institute of Electrical and Electronics Engineers,
    pp. 1595–1602, 2023.
  ista: Lechner M, Amini A, Rus D, Henzinger TA. 2023. Revisiting the adversarial
    robustness-accuracy tradeoff in robot learning. IEEE Robotics and Automation Letters.
    8(3), 1595–1602.
  mla: Lechner, Mathias, et al. “Revisiting the Adversarial Robustness-Accuracy Tradeoff
    in Robot Learning.” <i>IEEE Robotics and Automation Letters</i>, vol. 8, no. 3,
    Institute of Electrical and Electronics Engineers, 2023, pp. 1595–602, doi:<a
    href="https://doi.org/10.1109/LRA.2023.3240930">10.1109/LRA.2023.3240930</a>.
  short: M. Lechner, A. Amini, D. Rus, T.A. Henzinger, IEEE Robotics and Automation
    Letters 8 (2023) 1595–1602.
date_created: 2023-03-05T23:01:04Z
date_published: 2023-03-01T00:00:00Z
date_updated: 2025-04-14T09:42:58Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1109/LRA.2023.3240930
external_id:
  arxiv:
  - '2204.07373'
  isi:
  - '000936534100012'
file:
- access_level: open_access
  checksum: 5a75dcd326ea66685de2b1aaec259e85
  content_type: application/pdf
  creator: cchlebak
  date_created: 2023-03-07T12:22:23Z
  date_updated: 2023-03-07T12:22:23Z
  file_id: '12714'
  file_name: 2023_IEEERobAutLetters_Lechner.pdf
  file_size: 944052
  relation: main_file
  success: 1
file_date_updated: 2023-03-07T12:22:23Z
has_accepted_license: '1'
intvolume: '         8'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 1595-1602
publication: IEEE Robotics and Automation Letters
publication_identifier:
  eissn:
  - 2377-3766
publication_status: published
publisher: Institute of Electrical and Electronics Engineers
quality_controlled: '1'
related_material:
  record:
  - id: '11366'
    relation: earlier_version
    status: public
scopus_import: '1'
status: public
title: Revisiting the adversarial robustness-accuracy tradeoff in robot learning
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 8
year: '2023'
...
---
_id: '12705'
abstract:
- lang: eng
  text: The elasticity of disordered and polydisperse polymer networks is a fundamental
    problem of soft matter physics that is still open. Here, we self-assemble polymer
    networks via simulations of a mixture of bivalent and tri- or tetravalent patchy
    particles, which result in an exponential strand length distribution analogous
    to that of experimental randomly cross-linked systems. After assembly, the network
    connectivity and topology are frozen and the resulting system is characterized.
    We find that the fractal structure of the network depends on the number density
    at which the assembly has been carried out, but that systems with the same mean
    valence and same assembly density have the same structural properties. Moreover,
    we compute the long-time limit of the mean-squared displacement, also known as
    the (squared) localization length, of the cross-links and of the middle monomers
    of the strands, showing that the dynamics of long strands is well described by
    the tube model. Finally, we find a relation connecting these two localization
    lengths at high density and connect the cross-link localization length to the
    shear modulus of the system.
acknowledgement: We thank Michael Lang for helpful discussions. We acknowledge financial
  support from the European Research Council (ERC Consolidator Grant No. 681597, MIMIC)
  and from LabEx NUMEV (Grant No. ANR-10-LABX-20) funded by the “Investissements d’Avenir”
  French Government program, managed by the French National Research Agency (ANR).
  W.K. is a senior member of the Institut Universitaire de France.
article_number: '074905'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Valerio
  full_name: Sorichetti, Valerio
  id: ef8a92cb-c7b6-11ec-8bea-e1fd5847bc5b
  last_name: Sorichetti
  orcid: 0000-0002-9645-6576
- first_name: Andrea
  full_name: Ninarello, Andrea
  last_name: Ninarello
- first_name: José
  full_name: Ruiz-Franco, José
  last_name: Ruiz-Franco
- first_name: Virginie
  full_name: Hugouvieux, Virginie
  last_name: Hugouvieux
- first_name: Emanuela
  full_name: Zaccarelli, Emanuela
  last_name: Zaccarelli
- first_name: Cristian
  full_name: Micheletti, Cristian
  last_name: Micheletti
- first_name: Walter
  full_name: Kob, Walter
  last_name: Kob
- first_name: Lorenzo
  full_name: Rovigatti, Lorenzo
  last_name: Rovigatti
citation:
  ama: Sorichetti V, Ninarello A, Ruiz-Franco J, et al. Structure and elasticity of
    model disordered, polydisperse, and defect-free polymer networks. <i>Journal of
    Chemical Physics</i>. 2023;158(7). doi:<a href="https://doi.org/10.1063/5.0134271">10.1063/5.0134271</a>
  apa: Sorichetti, V., Ninarello, A., Ruiz-Franco, J., Hugouvieux, V., Zaccarelli,
    E., Micheletti, C., … Rovigatti, L. (2023). Structure and elasticity of model
    disordered, polydisperse, and defect-free polymer networks. <i>Journal of Chemical
    Physics</i>. American Institute of Physics. <a href="https://doi.org/10.1063/5.0134271">https://doi.org/10.1063/5.0134271</a>
  chicago: Sorichetti, Valerio, Andrea Ninarello, José Ruiz-Franco, Virginie Hugouvieux,
    Emanuela Zaccarelli, Cristian Micheletti, Walter Kob, and Lorenzo Rovigatti. “Structure
    and Elasticity of Model Disordered, Polydisperse, and Defect-Free Polymer Networks.”
    <i>Journal of Chemical Physics</i>. American Institute of Physics, 2023. <a href="https://doi.org/10.1063/5.0134271">https://doi.org/10.1063/5.0134271</a>.
  ieee: V. Sorichetti <i>et al.</i>, “Structure and elasticity of model disordered,
    polydisperse, and defect-free polymer networks,” <i>Journal of Chemical Physics</i>,
    vol. 158, no. 7. American Institute of Physics, 2023.
  ista: Sorichetti V, Ninarello A, Ruiz-Franco J, Hugouvieux V, Zaccarelli E, Micheletti
    C, Kob W, Rovigatti L. 2023. Structure and elasticity of model disordered, polydisperse,
    and defect-free polymer networks. Journal of Chemical Physics. 158(7), 074905.
  mla: Sorichetti, Valerio, et al. “Structure and Elasticity of Model Disordered,
    Polydisperse, and Defect-Free Polymer Networks.” <i>Journal of Chemical Physics</i>,
    vol. 158, no. 7, 074905, American Institute of Physics, 2023, doi:<a href="https://doi.org/10.1063/5.0134271">10.1063/5.0134271</a>.
  short: V. Sorichetti, A. Ninarello, J. Ruiz-Franco, V. Hugouvieux, E. Zaccarelli,
    C. Micheletti, W. Kob, L. Rovigatti, Journal of Chemical Physics 158 (2023).
date_created: 2023-03-05T23:01:05Z
date_published: 2023-02-21T00:00:00Z
date_updated: 2023-10-03T11:31:51Z
day: '21'
department:
- _id: AnSa
doi: 10.1063/5.0134271
external_id:
  arxiv:
  - '2211.04810'
  isi:
  - '000936943800002'
  pmid:
  - '36813705'
intvolume: '       158'
isi: 1
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2211.04810
month: '02'
oa: 1
oa_version: Preprint
pmid: 1
publication: Journal of Chemical Physics
publication_identifier:
  eissn:
  - 1089-7690
  issn:
  - 0021-9606
publication_status: published
publisher: American Institute of Physics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Structure and elasticity of model disordered, polydisperse, and defect-free
  polymer networks
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 158
year: '2023'
...
---
_id: '12706'
abstract:
- lang: eng
  text: Allometric settings of population dynamics models are appealing due to their
    parsimonious nature and broad utility when studying system level effects. Here,
    we parameterise the size-scaled Rosenzweig-MacArthur differential equations to
    eliminate prey-mass dependency, facilitating an in depth analytic study of the
    equations which incorporates scaling parameters’ contributions to coexistence.
    We define the functional response term to match empirical findings, and examine
    situations where metabolic theory derivations and observation diverge. The dynamical
    properties of the Rosenzweig-MacArthur system, encompassing the distribution of
    size-abundance equilibria, the scaling of period and amplitude of population cycling,
    and relationships between predator and prey abundances, are consistent with empirical
    observation. Our parameterisation is an accurate minimal model across 15+ orders
    of mass magnitude.
acknowledgement: "This research was supported by an Australian Government Research
  Training Program\r\n(RTP) Scholarship to JCM (https://www.dese.gov.au), and LB is
  supported by the Centre de\r\nrecherche sur le vieillissement Fellowship Program.
  The funders had no role in study design, data collection and analysis, decision
  to publish, or preparation of the manuscript."
article_processing_charge: No
article_type: original
author:
- first_name: Jody C.
  full_name: Mckerral, Jody C.
  last_name: Mckerral
- first_name: Maria
  full_name: Kleshnina, Maria
  id: 4E21749C-F248-11E8-B48F-1D18A9856A87
  last_name: Kleshnina
- first_name: Vladimir
  full_name: Ejov, Vladimir
  last_name: Ejov
- first_name: Louise
  full_name: Bartle, Louise
  last_name: Bartle
- first_name: James G.
  full_name: Mitchell, James G.
  last_name: Mitchell
- first_name: Jerzy A.
  full_name: Filar, Jerzy A.
  last_name: Filar
citation:
  ama: Mckerral JC, Kleshnina M, Ejov V, Bartle L, Mitchell JG, Filar JA. Empirical
    parameterisation and dynamical analysis of the allometric Rosenzweig-MacArthur
    equations. <i>PLoS One</i>. 2023;18(2):e0279838. doi:<a href="https://doi.org/10.1371/journal.pone.0279838">10.1371/journal.pone.0279838</a>
  apa: Mckerral, J. C., Kleshnina, M., Ejov, V., Bartle, L., Mitchell, J. G., &#38;
    Filar, J. A. (2023). Empirical parameterisation and dynamical analysis of the
    allometric Rosenzweig-MacArthur equations. <i>PLoS One</i>. Public Library of
    Science. <a href="https://doi.org/10.1371/journal.pone.0279838">https://doi.org/10.1371/journal.pone.0279838</a>
  chicago: Mckerral, Jody C., Maria Kleshnina, Vladimir Ejov, Louise Bartle, James
    G. Mitchell, and Jerzy A. Filar. “Empirical Parameterisation and Dynamical Analysis
    of the Allometric Rosenzweig-MacArthur Equations.” <i>PLoS One</i>. Public Library
    of Science, 2023. <a href="https://doi.org/10.1371/journal.pone.0279838">https://doi.org/10.1371/journal.pone.0279838</a>.
  ieee: J. C. Mckerral, M. Kleshnina, V. Ejov, L. Bartle, J. G. Mitchell, and J. A.
    Filar, “Empirical parameterisation and dynamical analysis of the allometric Rosenzweig-MacArthur
    equations,” <i>PLoS One</i>, vol. 18, no. 2. Public Library of Science, p. e0279838,
    2023.
  ista: Mckerral JC, Kleshnina M, Ejov V, Bartle L, Mitchell JG, Filar JA. 2023. Empirical
    parameterisation and dynamical analysis of the allometric Rosenzweig-MacArthur
    equations. PLoS One. 18(2), e0279838.
  mla: Mckerral, Jody C., et al. “Empirical Parameterisation and Dynamical Analysis
    of the Allometric Rosenzweig-MacArthur Equations.” <i>PLoS One</i>, vol. 18, no.
    2, Public Library of Science, 2023, p. e0279838, doi:<a href="https://doi.org/10.1371/journal.pone.0279838">10.1371/journal.pone.0279838</a>.
  short: J.C. Mckerral, M. Kleshnina, V. Ejov, L. Bartle, J.G. Mitchell, J.A. Filar,
    PLoS One 18 (2023) e0279838.
date_created: 2023-03-05T23:01:05Z
date_published: 2023-02-27T00:00:00Z
date_updated: 2023-10-17T12:53:30Z
day: '27'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1371/journal.pone.0279838
external_id:
  isi:
  - '000996122900022'
  pmid:
  - '36848357'
file:
- access_level: open_access
  checksum: 798ed5739a4117b03173e5d56e0534c9
  content_type: application/pdf
  creator: cchlebak
  date_created: 2023-03-07T10:26:45Z
  date_updated: 2023-03-07T10:26:45Z
  file_id: '12712'
  file_name: 2023_PLOSOne_Mckerral.pdf
  file_size: 1257003
  relation: main_file
  success: 1
file_date_updated: 2023-03-07T10:26:45Z
has_accepted_license: '1'
intvolume: '        18'
isi: 1
issue: '2'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: e0279838
pmid: 1
publication: PLoS One
publication_identifier:
  eissn:
  - 1932-6203
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Empirical parameterisation and dynamical analysis of the allometric Rosenzweig-MacArthur
  equations
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 18
year: '2023'
...
---
_id: '12707'
abstract:
- lang: eng
  text: We establish precise right-tail small deviation estimates for the largest
    eigenvalue of real symmetric and complex Hermitian matrices whose entries are
    independent random variables with uniformly bounded moments. The proof relies
    on a Green function comparison along a continuous interpolating matrix flow for
    a long time. Less precise estimates are also obtained in the left tail.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: László
  full_name: Erdös, László
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
- first_name: Yuanyuan
  full_name: Xu, Yuanyuan
  id: 7902bdb1-a2a4-11eb-a164-c9216f71aea3
  last_name: Xu
  orcid: 0000-0003-1559-1205
citation:
  ama: Erdös L, Xu Y. Small deviation estimates for the largest eigenvalue of Wigner
    matrices. <i>Bernoulli</i>. 2023;29(2):1063-1079. doi:<a href="https://doi.org/10.3150/22-BEJ1490">10.3150/22-BEJ1490</a>
  apa: Erdös, L., &#38; Xu, Y. (2023). Small deviation estimates for the largest eigenvalue
    of Wigner matrices. <i>Bernoulli</i>. Bernoulli Society for Mathematical Statistics
    and Probability. <a href="https://doi.org/10.3150/22-BEJ1490">https://doi.org/10.3150/22-BEJ1490</a>
  chicago: Erdös, László, and Yuanyuan Xu. “Small Deviation Estimates for the Largest
    Eigenvalue of Wigner Matrices.” <i>Bernoulli</i>. Bernoulli Society for Mathematical
    Statistics and Probability, 2023. <a href="https://doi.org/10.3150/22-BEJ1490">https://doi.org/10.3150/22-BEJ1490</a>.
  ieee: L. Erdös and Y. Xu, “Small deviation estimates for the largest eigenvalue
    of Wigner matrices,” <i>Bernoulli</i>, vol. 29, no. 2. Bernoulli Society for Mathematical
    Statistics and Probability, pp. 1063–1079, 2023.
  ista: Erdös L, Xu Y. 2023. Small deviation estimates for the largest eigenvalue
    of Wigner matrices. Bernoulli. 29(2), 1063–1079.
  mla: Erdös, László, and Yuanyuan Xu. “Small Deviation Estimates for the Largest
    Eigenvalue of Wigner Matrices.” <i>Bernoulli</i>, vol. 29, no. 2, Bernoulli Society
    for Mathematical Statistics and Probability, 2023, pp. 1063–79, doi:<a href="https://doi.org/10.3150/22-BEJ1490">10.3150/22-BEJ1490</a>.
  short: L. Erdös, Y. Xu, Bernoulli 29 (2023) 1063–1079.
corr_author: '1'
date_created: 2023-03-05T23:01:05Z
date_published: 2023-05-01T00:00:00Z
date_updated: 2025-04-14T07:57:19Z
day: '01'
department:
- _id: LaEr
doi: 10.3150/22-BEJ1490
ec_funded: 1
external_id:
  arxiv:
  - '2112.12093 '
  isi:
  - '000947270100008'
intvolume: '        29'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2112.12093
month: '05'
oa: 1
oa_version: Preprint
page: 1063-1079
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
  call_identifier: H2020
  grant_number: '101020331'
  name: Random matrices beyond Wigner-Dyson-Mehta
publication: Bernoulli
publication_identifier:
  issn:
  - 1350-7265
publication_status: published
publisher: Bernoulli Society for Mathematical Statistics and Probability
quality_controlled: '1'
scopus_import: '1'
status: public
title: Small deviation estimates for the largest eigenvalue of Wigner matrices
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2023'
...
---
_id: '12708'
abstract:
- lang: eng
  text: Self-organisation is the spontaneous emergence of spatio-temporal structures
    and patterns from the interaction of smaller individual units. Examples are found
    across many scales in very different systems and scientific disciplines, from
    physics, materials science and robotics to biology, geophysics and astronomy.
    Recent research has highlighted how self-organisation can be both mediated and
    controlled by confinement. Confinement is an action over a system that limits
    its units’ translational and rotational degrees of freedom, thus also influencing
    the system's phase space probability density; it can function as either a catalyst
    or inhibitor of self-organisation. Confinement can then become a means to actively
    steer the emergence or suppression of collective phenomena in space and time.
    Here, to provide a common framework and perspective for future research, we examine
    the role of confinement in the self-organisation of soft-matter systems and identify
    overarching scientific challenges that need to be addressed to harness its full
    scientific and technological potential in soft matter and related fields. By drawing
    analogies with other disciplines, this framework will accelerate a common deeper
    understanding of self-organisation and trigger the development of innovative strategies
    to steer it using confinement, with impact on, e.g., the design of smarter materials,
    tissue engineering for biomedicine and in guiding active matter.
acknowledgement: 'All authors are grateful to the Lorentz Center for providing a venue
  for stimulating scientific discussions and to sponsor a workshop on the topic of
  “Self-organisation under confinement” along with the 4TU Federation, the J. M. Burgers
  Center for Fluid Dynamics and the MESA+ Institute for Nanotechnology at the University
  of Twente. The authors are also grateful to Paolo Malgaretti, Federico Toschi, Twan
  Wilting and Jaap den Toonder for valuable feedback. N. A. acknowledges financial
  support from the Portuguese Foundation for Science and Technology (FCT) under Contracts
  no. PTDC/FIS-MAC/28146/2017 (LISBOA-01-0145-FEDER-028146), UIDB/00618/2020, and
  UIDP/00618/2020. L. M. C. J. acknowledges financial support from the Netherlands
  Organisation for Scientific Research (NWO) through a START-UP, Physics Projectruimte,
  and Vidi grant. I. C. was supported in part by a grant from by the Army Research
  Office (ARO W911NF-18-1-0032) and the Cornell Center for Materials Research (DMR-1719875).
  O. D. acknowledges funding by the Agence Nationale pour la Recherche under Grant
  No ANR-18-CE33-0006 MSR. M. D. acknowledges financial support from the European
  Research Council (Grant No. ERC-2019-ADV-H2020 884902 SoftML). W. M. D. acknowledges
  funding from a BBSRC New Investigator Grant (BB/R018383/1). S. G. was supported
  by DARPA Young Faculty Award # D19AP00046, and NSF IIS grant # 1955210. H. G. acknowledges
  financial support from the Netherlands Organisation for Scientific Research (NWO)
  through Veni Grant No. 680-47-451. R. G. acknowledges support from the Max Planck
  School Matter to Life and the MaxSynBio Consortium, which are jointly funded by
  the Federal Ministry of Education and Research (BMBF) of Germany, and the Max Planck
  Society. L. I. acknowledges funding from the Horizon Europe ERC Consolidator Grant
  ACTIVE_ ADAPTIVE (Grant No. 101001514). G. H. K. gratefully acknowledges the NWO
  Talent Programme which is financed by the Dutch Research Council (project number
  VI.C.182.004). H. L. and N. V. acknowledge funding from the Deutsche Forschungsgemeinschaft
  (DFG) under grant numbers VO 1824/8-1 and LO 418/22-1. R. M. acknowledges funding
  from the Deutsche Forschungsgemeinschaft (DFG) under grant number ME 1535/13-1 and
  ME 1535/16-1. M. P. acknowledges funding from the Ramón y Cajal Program, grant no.
  RYC-2018-02534, and the Leverhulme Trust, grant no. RPG-2018-345. A. Š. acknowledges
  financial support from the European Research Council (Grant No. ERC-2018-STG-H2020
  802960 NEPA). A. S. acknowledges funding from an ATTRACT Investigator Grant (No.
  A17/MS/11572821/MBRACE) from the Luxembourg National Research Fund. C. S. acknowledges
  funding from the French Agence Nationale pour la Recherche (ANR), grant ANR-14-CE090006
  and ANR-12-BSV5001401, by the Fondation pour la Recherche Médicale (FRM), grant
  DEQ20120323737, and from the PIC3I of Institut Curie, France. I. T. acknowledges
  funding from grant IED2019-00058I/AEI/10.13039/501100011033. M. P. and I. T. also
  acknowledge funding from grant PID2019-104232B-I00/AEI/10.13039/501100011033 and
  from the H2020 MSCA ITN PHYMOT (Grant agreement No 95591). I. Z. acknowledges funding
  from Project PID2020-114839GB-I00 MINECO/AEI/FEDER, UE. A. M. acknowledges funding
  from the European Research Council, Starting Grant No. 678573 NanoPacks. G. V. acknowledges
  sponsorship for this work by the US Office of Naval Research Global (Award No. N62909-18-1-2170).'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Nuno A.M.
  full_name: Araújo, Nuno A.M.
  last_name: Araújo
- first_name: Liesbeth M.C.
  full_name: Janssen, Liesbeth M.C.
  last_name: Janssen
- first_name: Thomas
  full_name: Barois, Thomas
  last_name: Barois
- first_name: Guido
  full_name: Boffetta, Guido
  last_name: Boffetta
- first_name: Itai
  full_name: Cohen, Itai
  last_name: Cohen
- first_name: Alessandro
  full_name: Corbetta, Alessandro
  last_name: Corbetta
- first_name: Olivier
  full_name: Dauchot, Olivier
  last_name: Dauchot
- first_name: Marjolein
  full_name: Dijkstra, Marjolein
  last_name: Dijkstra
- first_name: William M.
  full_name: Durham, William M.
  last_name: Durham
- first_name: Audrey
  full_name: Dussutour, Audrey
  last_name: Dussutour
- first_name: Simon
  full_name: Garnier, Simon
  last_name: Garnier
- first_name: Hanneke
  full_name: Gelderblom, Hanneke
  last_name: Gelderblom
- first_name: Ramin
  full_name: Golestanian, Ramin
  last_name: Golestanian
- first_name: Lucio
  full_name: Isa, Lucio
  last_name: Isa
- first_name: Gijsje H.
  full_name: Koenderink, Gijsje H.
  last_name: Koenderink
- first_name: Hartmut
  full_name: Löwen, Hartmut
  last_name: Löwen
- first_name: Ralf
  full_name: Metzler, Ralf
  last_name: Metzler
- first_name: Marco
  full_name: Polin, Marco
  last_name: Polin
- first_name: C. Patrick
  full_name: Royall, C. Patrick
  last_name: Royall
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: Anupam
  full_name: Sengupta, Anupam
  last_name: Sengupta
- first_name: Cécile
  full_name: Sykes, Cécile
  last_name: Sykes
- first_name: Vito
  full_name: Trianni, Vito
  last_name: Trianni
- first_name: Idan
  full_name: Tuval, Idan
  last_name: Tuval
- first_name: Nicolas
  full_name: Vogel, Nicolas
  last_name: Vogel
- first_name: Julia M.
  full_name: Yeomans, Julia M.
  last_name: Yeomans
- first_name: Iker
  full_name: Zuriguel, Iker
  last_name: Zuriguel
- first_name: Alvaro
  full_name: Marin, Alvaro
  last_name: Marin
- first_name: Giorgio
  full_name: Volpe, Giorgio
  last_name: Volpe
citation:
  ama: Araújo NAM, Janssen LMC, Barois T, et al. Steering self-organisation through
    confinement. <i>Soft Matter</i>. 2023;19:1695-1704. doi:<a href="https://doi.org/10.1039/d2sm01562e">10.1039/d2sm01562e</a>
  apa: Araújo, N. A. M., Janssen, L. M. C., Barois, T., Boffetta, G., Cohen, I., Corbetta,
    A., … Volpe, G. (2023). Steering self-organisation through confinement. <i>Soft
    Matter</i>. Royal Society of Chemistry. <a href="https://doi.org/10.1039/d2sm01562e">https://doi.org/10.1039/d2sm01562e</a>
  chicago: Araújo, Nuno A.M., Liesbeth M.C. Janssen, Thomas Barois, Guido Boffetta,
    Itai Cohen, Alessandro Corbetta, Olivier Dauchot, et al. “Steering Self-Organisation
    through Confinement.” <i>Soft Matter</i>. Royal Society of Chemistry, 2023. <a
    href="https://doi.org/10.1039/d2sm01562e">https://doi.org/10.1039/d2sm01562e</a>.
  ieee: N. A. M. Araújo <i>et al.</i>, “Steering self-organisation through confinement,”
    <i>Soft Matter</i>, vol. 19. Royal Society of Chemistry, pp. 1695–1704, 2023.
  ista: Araújo NAM, Janssen LMC, Barois T, Boffetta G, Cohen I, Corbetta A, Dauchot
    O, Dijkstra M, Durham WM, Dussutour A, Garnier S, Gelderblom H, Golestanian R,
    Isa L, Koenderink GH, Löwen H, Metzler R, Polin M, Royall CP, Šarić A, Sengupta
    A, Sykes C, Trianni V, Tuval I, Vogel N, Yeomans JM, Zuriguel I, Marin A, Volpe
    G. 2023. Steering self-organisation through confinement. Soft Matter. 19, 1695–1704.
  mla: Araújo, Nuno A. M., et al. “Steering Self-Organisation through Confinement.”
    <i>Soft Matter</i>, vol. 19, Royal Society of Chemistry, 2023, pp. 1695–704, doi:<a
    href="https://doi.org/10.1039/d2sm01562e">10.1039/d2sm01562e</a>.
  short: N.A.M. Araújo, L.M.C. Janssen, T. Barois, G. Boffetta, I. Cohen, A. Corbetta,
    O. Dauchot, M. Dijkstra, W.M. Durham, A. Dussutour, S. Garnier, H. Gelderblom,
    R. Golestanian, L. Isa, G.H. Koenderink, H. Löwen, R. Metzler, M. Polin, C.P.
    Royall, A. Šarić, A. Sengupta, C. Sykes, V. Trianni, I. Tuval, N. Vogel, J.M.
    Yeomans, I. Zuriguel, A. Marin, G. Volpe, Soft Matter 19 (2023) 1695–1704.
date_created: 2023-03-05T23:01:06Z
date_published: 2023-02-06T00:00:00Z
date_updated: 2025-04-23T08:48:51Z
day: '06'
ddc:
- '540'
department:
- _id: AnSa
doi: 10.1039/d2sm01562e
ec_funded: 1
external_id:
  arxiv:
  - '2204.10059'
  isi:
  - '000940388100001'
  pmid:
  - '36779972'
file:
- access_level: open_access
  checksum: af95aa18b9b01e32fb8f13477c0e2687
  content_type: application/pdf
  creator: cchlebak
  date_created: 2023-03-07T09:19:41Z
  date_updated: 2023-03-07T09:19:41Z
  file_id: '12711'
  file_name: 2023_SoftMatter_Araujo.pdf
  file_size: 3581939
  relation: main_file
  success: 1
file_date_updated: 2023-03-07T09:19:41Z
has_accepted_license: '1'
intvolume: '        19'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 1695-1704
pmid: 1
project:
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
  call_identifier: H2020
  grant_number: '802960'
  name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
publication: Soft Matter
publication_identifier:
  eissn:
  - 1744-6848
  issn:
  - 1744-683X
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: Steering self-organisation through confinement
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2023'
...
---
_id: '12709'
abstract:
- lang: eng
  text: Given a finite set A ⊂ ℝ^d, let Cov_{r,k} denote the set of all points within
    distance r to at least k points of A. Allowing r and k to vary, we obtain a 2-parameter
    family of spaces that grow larger when r increases or k decreases, called the
    multicover bifiltration. Motivated by the problem of computing the homology of
    this bifiltration, we introduce two closely related combinatorial bifiltrations,
    one polyhedral and the other simplicial, which are both topologically equivalent
    to the multicover bifiltration and far smaller than a Čech-based model considered
    in prior work of Sheehy. Our polyhedral construction is a bifiltration of the
    rhomboid tiling of Edelsbrunner and Osang, and can be efficiently computed using
    a variant of an algorithm given by these authors as well. Using an implementation
    for dimension 2 and 3, we provide experimental results. Our simplicial construction
    is useful for understanding the polyhedral construction and proving its correctness.
acknowledgement: We thank the anonymous reviewers for many helpful comments and suggestions,
  which led to substantial improvements of the paper. The first two authors were supported
  by the Austrian Science Fund (FWF) grant number P 29984-N35 and W1230. The first
  author was partly supported by an Austrian Marshall Plan Scholarship, and by the
  Brummer & Partners MathDataLab. A conference version of this paper was presented
  at the 37th International Symposium on Computational Geometry (SoCG 2021). Open
  access funding provided by the Royal Institute of Technology.
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: René
  full_name: Corbet, René
  last_name: Corbet
- first_name: Michael
  full_name: Kerber, Michael
  id: 36E4574A-F248-11E8-B48F-1D18A9856A87
  last_name: Kerber
  orcid: 0000-0002-8030-9299
- first_name: Michael
  full_name: Lesnick, Michael
  last_name: Lesnick
- first_name: Georg F
  full_name: Osang, Georg F
  id: 464B40D6-F248-11E8-B48F-1D18A9856A87
  last_name: Osang
  orcid: 0000-0002-8882-5116
citation:
  ama: Corbet R, Kerber M, Lesnick M, Osang GF. Computing the multicover bifiltration.
    <i>Discrete and Computational Geometry</i>. 2023;70:376-405. doi:<a href="https://doi.org/10.1007/s00454-022-00476-8">10.1007/s00454-022-00476-8</a>
  apa: Corbet, R., Kerber, M., Lesnick, M., &#38; Osang, G. F. (2023). Computing the
    multicover bifiltration. <i>Discrete and Computational Geometry</i>. Springer
    Nature. <a href="https://doi.org/10.1007/s00454-022-00476-8">https://doi.org/10.1007/s00454-022-00476-8</a>
  chicago: Corbet, René, Michael Kerber, Michael Lesnick, and Georg F Osang. “Computing
    the Multicover Bifiltration.” <i>Discrete and Computational Geometry</i>. Springer
    Nature, 2023. <a href="https://doi.org/10.1007/s00454-022-00476-8">https://doi.org/10.1007/s00454-022-00476-8</a>.
  ieee: R. Corbet, M. Kerber, M. Lesnick, and G. F. Osang, “Computing the multicover
    bifiltration,” <i>Discrete and Computational Geometry</i>, vol. 70. Springer Nature,
    pp. 376–405, 2023.
  ista: Corbet R, Kerber M, Lesnick M, Osang GF. 2023. Computing the multicover bifiltration.
    Discrete and Computational Geometry. 70, 376–405.
  mla: Corbet, René, et al. “Computing the Multicover Bifiltration.” <i>Discrete and
    Computational Geometry</i>, vol. 70, Springer Nature, 2023, pp. 376–405, doi:<a
    href="https://doi.org/10.1007/s00454-022-00476-8">10.1007/s00454-022-00476-8</a>.
  short: R. Corbet, M. Kerber, M. Lesnick, G.F. Osang, Discrete and Computational
    Geometry 70 (2023) 376–405.
date_created: 2023-03-05T23:01:06Z
date_published: 2023-09-01T00:00:00Z
date_updated: 2025-07-10T12:01:57Z
day: '01'
ddc:
- '000'
department:
- _id: HeEd
doi: 10.1007/s00454-022-00476-8
external_id:
  arxiv:
  - '2103.07823'
  isi:
  - '000936496800001'
  pmid:
  - '37581017'
file:
- access_level: open_access
  checksum: 71ce7e59f7ee4620acc704fecca620c2
  content_type: application/pdf
  creator: cchlebak
  date_created: 2023-03-07T14:40:14Z
  date_updated: 2023-03-07T14:40:14Z
  file_id: '12715'
  file_name: 2023_DisCompGeo_Corbet.pdf
  file_size: 1359323
  relation: main_file
  success: 1
file_date_updated: 2023-03-07T14:40:14Z
has_accepted_license: '1'
intvolume: '        70'
isi: 1
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 376-405
pmid: 1
publication: Discrete and Computational Geometry
publication_identifier:
  eissn:
  - 1432-0444
  issn:
  - 0179-5376
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  record:
  - id: '9605'
    relation: earlier_version
    status: public
scopus_import: '1'
status: public
title: Computing the multicover bifiltration
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 70
year: '2023'
...
---
_id: '12710'
abstract:
- lang: eng
  text: Surface curvature both emerges from, and influences the behavior of, living
    objects at length scales ranging from cell membranes to single cells to tissues
    and organs. The relevance of surface curvature in biology is supported by numerous
    experimental and theoretical investigations in recent years. In this review, first,
    a brief introduction to the key ideas of surface curvature in the context of biological
    systems is given and the challenges that arise when measuring surface curvature
    are discussed. Giving an overview of the emergence of curvature in biological
    systems, its significance at different length scales becomes apparent. On the
    other hand, summarizing current findings also shows that both single cells and
    entire cell sheets, tissues or organisms respond to curvature by modulating their
    shape and their migration behavior. Finally, the interplay between the distribution
    of morphogens or micro-organisms and the emergence of curvature across length
    scales is addressed with examples demonstrating these key mechanistic principles
    of morphogenesis. Overall, this review highlights that curved interfaces are not
    merely a passive by-product of the chemical, biological, and mechanical processes
    but that curvature acts also as a signal that co-determines these processes.
acknowledgement: B.S. and A.R. contributed equally to this work. A.P.G.C. and P.R.F.
  acknowledge the funding from Fundação para a Ciência e Tecnologia (Portugal), through
  IDMEC, under LAETA project UIDB/50022/2020. T.H.V.P. acknowledges the funding from
  Fundação para a Ciência e Tecnologia (Portugal), through Ph.D. Grant 2020.04417.BD.
  A.S. acknowledges that this work was partially supported by the ATTRACT Investigator
  Grant (no. A17/MS/11572821/MBRACE, to A.S.) from the Luxembourg National Research
  Fund. The author thanks Gerardo Ceada for his help in the graphical representations.
  N.A.K. acknowledges support from the European Research Council (grant 851960) and
  the Gravitation Program “Materials Driven Regeneration,” funded by the Netherlands
  Organization for Scientific Research (024.003.013). M.B.A. acknowledges support
  from the French National Research Agency (grant ANR-201-8-CE1-3-0008 for the project
  “Epimorph”). G.E.S.T. acknowledges funding by the Australian Research Council through
  project DP200102593. A.C. acknowledges the funding from the Deutsche Forschungsgemeinschaft
  (DFG) Emmy Noether Grant CI 203/-2 1, the Spanish Ministry of Science and Innovation
  (PID2021-123013O-BI00) and the IKERBASQUE Basque Foundation for Science.
article_number: '2206110'
article_processing_charge: No
article_type: review
author:
- first_name: Barbara
  full_name: Schamberger, Barbara
  last_name: Schamberger
- first_name: Ricardo
  full_name: Ziege, Ricardo
  last_name: Ziege
- first_name: Karine
  full_name: Anselme, Karine
  last_name: Anselme
- first_name: Martine
  full_name: Ben Amar, Martine
  last_name: Ben Amar
- first_name: Michał
  full_name: Bykowski, Michał
  last_name: Bykowski
- first_name: André P.G.
  full_name: Castro, André P.G.
  last_name: Castro
- first_name: Amaia
  full_name: Cipitria, Amaia
  last_name: Cipitria
- first_name: Rhoslyn A.
  full_name: Coles, Rhoslyn A.
  last_name: Coles
- first_name: Rumiana
  full_name: Dimova, Rumiana
  last_name: Dimova
- first_name: Michaela
  full_name: Eder, Michaela
  last_name: Eder
- first_name: Sebastian
  full_name: Ehrig, Sebastian
  last_name: Ehrig
- first_name: Luis M.
  full_name: Escudero, Luis M.
  last_name: Escudero
- first_name: Myfanwy E.
  full_name: Evans, Myfanwy E.
  last_name: Evans
- first_name: Paulo R.
  full_name: Fernandes, Paulo R.
  last_name: Fernandes
- first_name: Peter
  full_name: Fratzl, Peter
  last_name: Fratzl
- first_name: Liesbet
  full_name: Geris, Liesbet
  last_name: Geris
- first_name: Notburga
  full_name: Gierlinger, Notburga
  last_name: Gierlinger
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Aleš
  full_name: Iglič, Aleš
  last_name: Iglič
- first_name: Jacob J.K.
  full_name: Kirkensgaard, Jacob J.K.
  last_name: Kirkensgaard
- first_name: Philip
  full_name: Kollmannsberger, Philip
  last_name: Kollmannsberger
- first_name: Łucja
  full_name: Kowalewska, Łucja
  last_name: Kowalewska
- first_name: Nicholas A.
  full_name: Kurniawan, Nicholas A.
  last_name: Kurniawan
- first_name: Ioannis
  full_name: Papantoniou, Ioannis
  last_name: Papantoniou
- first_name: Laurent
  full_name: Pieuchot, Laurent
  last_name: Pieuchot
- first_name: Tiago H.V.
  full_name: Pires, Tiago H.V.
  last_name: Pires
- first_name: Lars D.
  full_name: Renner, Lars D.
  last_name: Renner
- first_name: Andrew O.
  full_name: Sageman-Furnas, Andrew O.
  last_name: Sageman-Furnas
- first_name: Gerd E.
  full_name: Schröder-Turk, Gerd E.
  last_name: Schröder-Turk
- first_name: Anupam
  full_name: Sengupta, Anupam
  last_name: Sengupta
- first_name: Vikas R.
  full_name: Sharma, Vikas R.
  last_name: Sharma
- first_name: Antonio
  full_name: Tagua, Antonio
  last_name: Tagua
- first_name: Caterina
  full_name: Tomba, Caterina
  last_name: Tomba
- first_name: Xavier
  full_name: Trepat, Xavier
  last_name: Trepat
- first_name: Sarah L.
  full_name: Waters, Sarah L.
  last_name: Waters
- first_name: Edwina F.
  full_name: Yeo, Edwina F.
  last_name: Yeo
- first_name: Andreas
  full_name: Roschger, Andreas
  last_name: Roschger
- first_name: Cécile M.
  full_name: Bidan, Cécile M.
  last_name: Bidan
- first_name: John W.C.
  full_name: Dunlop, John W.C.
  last_name: Dunlop
citation:
  ama: 'Schamberger B, Ziege R, Anselme K, et al. Curvature in biological systems:
    Its quantification, emergence, and implications across the scales. <i>Advanced
    Materials</i>. 2023;35(13). doi:<a href="https://doi.org/10.1002/adma.202206110">10.1002/adma.202206110</a>'
  apa: 'Schamberger, B., Ziege, R., Anselme, K., Ben Amar, M., Bykowski, M., Castro,
    A. P. G., … Dunlop, J. W. C. (2023). Curvature in biological systems: Its quantification,
    emergence, and implications across the scales. <i>Advanced Materials</i>. Wiley.
    <a href="https://doi.org/10.1002/adma.202206110">https://doi.org/10.1002/adma.202206110</a>'
  chicago: 'Schamberger, Barbara, Ricardo Ziege, Karine Anselme, Martine Ben Amar,
    Michał Bykowski, André P.G. Castro, Amaia Cipitria, et al. “Curvature in Biological
    Systems: Its Quantification, Emergence, and Implications across the Scales.” <i>Advanced
    Materials</i>. Wiley, 2023. <a href="https://doi.org/10.1002/adma.202206110">https://doi.org/10.1002/adma.202206110</a>.'
  ieee: 'B. Schamberger <i>et al.</i>, “Curvature in biological systems: Its quantification,
    emergence, and implications across the scales,” <i>Advanced Materials</i>, vol.
    35, no. 13. Wiley, 2023.'
  ista: 'Schamberger B, Ziege R, Anselme K, Ben Amar M, Bykowski M, Castro APG, Cipitria
    A, Coles RA, Dimova R, Eder M, Ehrig S, Escudero LM, Evans ME, Fernandes PR, Fratzl
    P, Geris L, Gierlinger N, Hannezo EB, Iglič A, Kirkensgaard JJK, Kollmannsberger
    P, Kowalewska Ł, Kurniawan NA, Papantoniou I, Pieuchot L, Pires THV, Renner LD,
    Sageman-Furnas AO, Schröder-Turk GE, Sengupta A, Sharma VR, Tagua A, Tomba C,
    Trepat X, Waters SL, Yeo EF, Roschger A, Bidan CM, Dunlop JWC. 2023. Curvature
    in biological systems: Its quantification, emergence, and implications across
    the scales. Advanced Materials. 35(13), 2206110.'
  mla: 'Schamberger, Barbara, et al. “Curvature in Biological Systems: Its Quantification,
    Emergence, and Implications across the Scales.” <i>Advanced Materials</i>, vol.
    35, no. 13, 2206110, Wiley, 2023, doi:<a href="https://doi.org/10.1002/adma.202206110">10.1002/adma.202206110</a>.'
  short: B. Schamberger, R. Ziege, K. Anselme, M. Ben Amar, M. Bykowski, A.P.G. Castro,
    A. Cipitria, R.A. Coles, R. Dimova, M. Eder, S. Ehrig, L.M. Escudero, M.E. Evans,
    P.R. Fernandes, P. Fratzl, L. Geris, N. Gierlinger, E.B. Hannezo, A. Iglič, J.J.K.
    Kirkensgaard, P. Kollmannsberger, Ł. Kowalewska, N.A. Kurniawan, I. Papantoniou,
    L. Pieuchot, T.H.V. Pires, L.D. Renner, A.O. Sageman-Furnas, G.E. Schröder-Turk,
    A. Sengupta, V.R. Sharma, A. Tagua, C. Tomba, X. Trepat, S.L. Waters, E.F. Yeo,
    A. Roschger, C.M. Bidan, J.W.C. Dunlop, Advanced Materials 35 (2023).
date_created: 2023-03-05T23:01:06Z
date_published: 2023-03-29T00:00:00Z
date_updated: 2023-09-26T10:56:46Z
day: '29'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1002/adma.202206110
external_id:
  isi:
  - '000941068900001'
  pmid:
  - '36461812'
file:
- access_level: open_access
  checksum: 5c04d68130e97a0ecd1ca27fbc15a246
  content_type: application/pdf
  creator: dernst
  date_created: 2023-09-26T10:51:56Z
  date_updated: 2023-09-26T10:51:56Z
  file_id: '14373'
  file_name: 2023_AdvancedMaterials_Schamberger.pdf
  file_size: 2898063
  relation: main_file
  success: 1
file_date_updated: 2023-09-26T10:51:56Z
has_accepted_license: '1'
intvolume: '        35'
isi: 1
issue: '13'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: Advanced Materials
publication_identifier:
  eissn:
  - 1521-4095
  issn:
  - 0935-9648
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Curvature in biological systems: Its quantification, emergence, and implications
  across the scales'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 35
year: '2023'
...
---
_id: '12719'
abstract:
- lang: eng
  text: "Background\r\nEpigenetic clocks can track both chronological age (cAge) and
    biological age (bAge). The latter is typically defined by physiological biomarkers
    and risk of adverse health outcomes, including all-cause mortality. As cohort
    sample sizes increase, estimates of cAge and bAge become more precise. Here, we
    aim to develop accurate epigenetic predictors of cAge and bAge, whilst improving
    our understanding of their epigenomic architecture.\r\n\r\nMethods\r\nFirst, we
    perform large-scale (N = 18,413) epigenome-wide association studies (EWAS) of
    chronological age and all-cause mortality. Next, to create a cAge predictor, we
    use methylation data from 24,674 participants from the Generation Scotland study,
    the Lothian Birth Cohorts (LBC) of 1921 and 1936, and 8 other cohorts with publicly
    available data. In addition, we train a predictor of time to all-cause mortality
    as a proxy for bAge using the Generation Scotland cohort (1214 observed deaths).
    For this purpose, we use epigenetic surrogates (EpiScores) for 109 plasma proteins
    and the 8 component parts of GrimAge, one of the current best epigenetic predictors
    of survival. We test this bAge predictor in four external cohorts (LBC1921, LBC1936,
    the Framingham Heart Study and the Women’s Health Initiative study).\r\n\r\nResults\r\nThrough
    the inclusion of linear and non-linear age-CpG associations from the EWAS, feature
    pre-selection in advance of elastic net regression, and a leave-one-cohort-out
    (LOCO) cross-validation framework, we obtain cAge prediction with a median absolute
    error equal to 2.3 years. Our bAge predictor was found to slightly outperform
    GrimAge in terms of the strength of its association to survival (HRGrimAge = 1.47
    [1.40, 1.54] with p = 1.08 × 10−52, and HRbAge = 1.52 [1.44, 1.59] with p = 2.20 × 10−60).
    Finally, we introduce MethylBrowsR, an online tool to visualise epigenome-wide
    CpG-age associations.\r\n\r\nConclusions\r\nThe integration of multiple large
    datasets, EpiScores, non-linear DNAm effects, and new approaches to feature selection
    has facilitated improvements to the blood-based epigenetic prediction of biological
    and chronological age."
acknowledgement: We are grateful to all the families who took part, the general practitioners,
  and the Scottish School of Primary Care for their help in recruiting them and the
  whole GS team that includes interviewers, computer and laboratory technicians, clerical
  workers, research scientists, volunteers, managers, receptionists, healthcare assistants,
  and nurses.
article_number: '12'
article_processing_charge: No
article_type: original
author:
- first_name: Elena
  full_name: Bernabeu, Elena
  last_name: Bernabeu
- first_name: Daniel L.
  full_name: Mccartney, Daniel L.
  last_name: Mccartney
- first_name: Danni A.
  full_name: Gadd, Danni A.
  last_name: Gadd
- first_name: Robert F.
  full_name: Hillary, Robert F.
  last_name: Hillary
- first_name: Ake T.
  full_name: Lu, Ake T.
  last_name: Lu
- first_name: Lee
  full_name: Murphy, Lee
  last_name: Murphy
- first_name: Nicola
  full_name: Wrobel, Nicola
  last_name: Wrobel
- first_name: Archie
  full_name: Campbell, Archie
  last_name: Campbell
- first_name: Sarah E.
  full_name: Harris, Sarah E.
  last_name: Harris
- first_name: David
  full_name: Liewald, David
  last_name: Liewald
- first_name: Caroline
  full_name: Hayward, Caroline
  last_name: Hayward
- first_name: Cathie
  full_name: Sudlow, Cathie
  last_name: Sudlow
- first_name: Simon R.
  full_name: Cox, Simon R.
  last_name: Cox
- first_name: Kathryn L.
  full_name: Evans, Kathryn L.
  last_name: Evans
- first_name: Steve
  full_name: Horvath, Steve
  last_name: Horvath
- first_name: Andrew M.
  full_name: Mcintosh, Andrew M.
  last_name: Mcintosh
- first_name: Matthew Richard
  full_name: Robinson, Matthew Richard
  id: E5D42276-F5DA-11E9-8E24-6303E6697425
  last_name: Robinson
  orcid: 0000-0001-8982-8813
- first_name: Catalina A.
  full_name: Vallejos, Catalina A.
  last_name: Vallejos
- first_name: Riccardo E.
  full_name: Marioni, Riccardo E.
  last_name: Marioni
citation:
  ama: Bernabeu E, Mccartney DL, Gadd DA, et al. Refining epigenetic prediction of
    chronological and biological age. <i>Genome Medicine</i>. 2023;15. doi:<a href="https://doi.org/10.1186/s13073-023-01161-y">10.1186/s13073-023-01161-y</a>
  apa: Bernabeu, E., Mccartney, D. L., Gadd, D. A., Hillary, R. F., Lu, A. T., Murphy,
    L., … Marioni, R. E. (2023). Refining epigenetic prediction of chronological and
    biological age. <i>Genome Medicine</i>. Springer Nature. <a href="https://doi.org/10.1186/s13073-023-01161-y">https://doi.org/10.1186/s13073-023-01161-y</a>
  chicago: Bernabeu, Elena, Daniel L. Mccartney, Danni A. Gadd, Robert F. Hillary,
    Ake T. Lu, Lee Murphy, Nicola Wrobel, et al. “Refining Epigenetic Prediction of
    Chronological and Biological Age.” <i>Genome Medicine</i>. Springer Nature, 2023.
    <a href="https://doi.org/10.1186/s13073-023-01161-y">https://doi.org/10.1186/s13073-023-01161-y</a>.
  ieee: E. Bernabeu <i>et al.</i>, “Refining epigenetic prediction of chronological
    and biological age,” <i>Genome Medicine</i>, vol. 15. Springer Nature, 2023.
  ista: Bernabeu E, Mccartney DL, Gadd DA, Hillary RF, Lu AT, Murphy L, Wrobel N,
    Campbell A, Harris SE, Liewald D, Hayward C, Sudlow C, Cox SR, Evans KL, Horvath
    S, Mcintosh AM, Robinson MR, Vallejos CA, Marioni RE. 2023. Refining epigenetic
    prediction of chronological and biological age. Genome Medicine. 15, 12.
  mla: Bernabeu, Elena, et al. “Refining Epigenetic Prediction of Chronological and
    Biological Age.” <i>Genome Medicine</i>, vol. 15, 12, Springer Nature, 2023, doi:<a
    href="https://doi.org/10.1186/s13073-023-01161-y">10.1186/s13073-023-01161-y</a>.
  short: E. Bernabeu, D.L. Mccartney, D.A. Gadd, R.F. Hillary, A.T. Lu, L. Murphy,
    N. Wrobel, A. Campbell, S.E. Harris, D. Liewald, C. Hayward, C. Sudlow, S.R. Cox,
    K.L. Evans, S. Horvath, A.M. Mcintosh, M.R. Robinson, C.A. Vallejos, R.E. Marioni,
    Genome Medicine 15 (2023).
date_created: 2023-03-12T23:01:02Z
date_published: 2023-02-28T00:00:00Z
date_updated: 2025-04-23T08:49:38Z
day: '28'
ddc:
- '570'
department:
- _id: MaRo
doi: 10.1186/s13073-023-01161-y
external_id:
  isi:
  - '000940286600001'
  pmid:
  - '36855161'
file:
- access_level: open_access
  checksum: 833b837910c4db42fb5f0f34125f77a7
  content_type: application/pdf
  creator: cchlebak
  date_created: 2023-03-14T10:29:47Z
  date_updated: 2023-03-14T10:29:47Z
  file_id: '12722'
  file_name: 2023_GenomeMed_Bernabeu.pdf
  file_size: 4275987
  relation: main_file
  success: 1
file_date_updated: 2023-03-14T10:29:47Z
has_accepted_license: '1'
intvolume: '        15'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Genome Medicine
publication_identifier:
  eissn:
  - 1756-994X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Refining epigenetic prediction of chronological and biological age
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2023'
...
---
OA_place: repository
OA_type: green
_id: '12720'
abstract:
- lang: eng
  text: Here we describe the in vivo DNA assembly approach, where molecular cloning
    procedures are performed using an E. coli recA-independent recombination pathway,
    which assembles linear fragments of DNA with short homologous termini. This pathway
    is present in all standard laboratory E. coli strains and, by bypassing the need
    for in vitro DNA assembly, allows simplified molecular cloning to be performed
    without the plasmid instability issues associated with specialized recombination-cloning
    bacterial strains. The methodology requires specific primer design and can perform
    all standard plasmid modifications (insertions, deletions, mutagenesis, and sub-cloning)
    in a rapid, simple, and cost-efficient manner, as it does not require commercial
    kits or specialized bacterial strains. Additionally, this approach can be used
    to perform complex procedures such as multiple modifications to a plasmid, as
    up to 6 linear fragments can be assembled in vivo by this recombination pathway.
    Procedures generally require less than 3 h, involving PCR amplification, DpnI
    digestion of template DNA, and transformation, upon which circular plasmids are
    assembled. In this chapter we describe the requirements, procedure, and potential
    pitfalls when using this technique, as well as protocol variations to overcome
    the most common issues.
alternative_title:
- Methods in Molecular Biology
article_processing_charge: No
author:
- first_name: Sandra
  full_name: Arroyo-Urea, Sandra
  last_name: Arroyo-Urea
- first_name: Jake
  full_name: Watson, Jake
  id: 63836096-4690-11EA-BD4E-32803DDC885E
  last_name: Watson
  orcid: 0000-0002-8698-3823
- first_name: Javier
  full_name: García-Nafría, Javier
  last_name: García-Nafría
citation:
  ama: 'Arroyo-Urea S, Watson J, García-Nafría J. Molecular Cloning Using In Vivo
    DNA Assembly. In: Scarlett G, ed. <i>DNA Manipulation and Analysis</i>. Vol 2633.
    MIMB. New York, NY, United States: Springer Nature; 2023:33-44. doi:<a href="https://doi.org/10.1007/978-1-0716-3004-4_3">10.1007/978-1-0716-3004-4_3</a>'
  apa: 'Arroyo-Urea, S., Watson, J., &#38; García-Nafría, J. (2023). Molecular Cloning
    Using In Vivo DNA Assembly. In G. Scarlett (Ed.), <i>DNA Manipulation and Analysis</i>
    (Vol. 2633, pp. 33–44). New York, NY, United States: Springer Nature. <a href="https://doi.org/10.1007/978-1-0716-3004-4_3">https://doi.org/10.1007/978-1-0716-3004-4_3</a>'
  chicago: 'Arroyo-Urea, Sandra, Jake Watson, and Javier García-Nafría. “Molecular
    Cloning Using In Vivo DNA Assembly.” In <i>DNA Manipulation and Analysis</i>,
    edited by Garry Scarlett, 2633:33–44. MIMB. New York, NY, United States: Springer
    Nature, 2023. <a href="https://doi.org/10.1007/978-1-0716-3004-4_3">https://doi.org/10.1007/978-1-0716-3004-4_3</a>.'
  ieee: 'S. Arroyo-Urea, J. Watson, and J. García-Nafría, “Molecular Cloning Using
    In Vivo DNA Assembly,” in <i>DNA Manipulation and Analysis</i>, vol. 2633, G.
    Scarlett, Ed. New York, NY, United States: Springer Nature, 2023, pp. 33–44.'
  ista: 'Arroyo-Urea S, Watson J, García-Nafría J. 2023.Molecular Cloning Using In
    Vivo DNA Assembly. In: DNA Manipulation and Analysis. Methods in Molecular Biology,
    vol. 2633, 33–44.'
  mla: Arroyo-Urea, Sandra, et al. “Molecular Cloning Using In Vivo DNA Assembly.”
    <i>DNA Manipulation and Analysis</i>, edited by Garry Scarlett, vol. 2633, Springer
    Nature, 2023, pp. 33–44, doi:<a href="https://doi.org/10.1007/978-1-0716-3004-4_3">10.1007/978-1-0716-3004-4_3</a>.
  short: S. Arroyo-Urea, J. Watson, J. García-Nafría, in:, G. Scarlett (Ed.), DNA
    Manipulation and Analysis, Springer Nature, New York, NY, United States, 2023,
    pp. 33–44.
date_created: 2023-03-12T23:01:02Z
date_published: 2023-03-01T00:00:00Z
date_updated: 2025-06-25T05:56:45Z
day: '01'
department:
- _id: PeJo
doi: 10.1007/978-1-0716-3004-4_3
editor:
- first_name: Garry
  full_name: Scarlett, Garry
  last_name: Scarlett
external_id:
  pmid:
  - '36853454'
intvolume: '      2633'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://zaguan.unizar.es/record/125930/files/texto_completo.pdf
month: '03'
oa: 1
oa_version: Submitted Version
page: 33-44
place: New York, NY, United States
pmid: 1
publication: DNA Manipulation and Analysis
publication_identifier:
  eisbn:
  - 978-1-0716-3004-4
  eissn:
  - 1940-6029
  isbn:
  - 978-1-0716-3003-7
  issn:
  - 1064-3745
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
series_title: MIMB
status: public
title: Molecular Cloning Using In Vivo DNA Assembly
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2633
year: '2023'
...
---
_id: '12723'
abstract:
- lang: eng
  text: 'Lead halide perovskites enjoy a number of remarkable optoelectronic properties.
    To explain their origin, it is necessary to study how electromagnetic fields interact
    with these systems. We address this problem here by studying two classical quantities:
    Faraday rotation and the complex refractive index in a paradigmatic perovskite
    CH3NH3PbBr3 in a broad wavelength range. We find that the minimal coupling of
    electromagnetic fields to the k⋅p Hamiltonian is insufficient to describe the
    observed data even on the qualitative level. To amend this, we demonstrate that
    there exists a relevant atomic-level coupling between electromagnetic fields and
    the spin degree of freedom. This spin-electric coupling allows for quantitative
    description of a number of previous as well as present experimental data. In particular,
    we use it here to show that the Faraday effect in lead halide perovskites is dominated
    by the Zeeman splitting of the energy levels and has a substantial beyond-Becquerel
    contribution. Finally, we present general symmetry-based phenomenological arguments
    that in the low-energy limit our effective model includes all basis coupling terms
    to the electromagnetic field in the linear order.'
article_number: '106901'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Artem
  full_name: Volosniev, Artem
  id: 37D278BC-F248-11E8-B48F-1D18A9856A87
  last_name: Volosniev
  orcid: 0000-0003-0393-5525
- first_name: Abhishek
  full_name: Shiva Kumar, Abhishek
  id: 5e9a6931-eb97-11eb-a6c2-e96f7058d77a
  last_name: Shiva Kumar
- first_name: Dusan
  full_name: Lorenc, Dusan
  id: 40D8A3E6-F248-11E8-B48F-1D18A9856A87
  last_name: Lorenc
- first_name: Younes
  full_name: Ashourishokri, Younes
  id: e32c111f-f6e0-11ea-865d-eb955baea334
  last_name: Ashourishokri
- first_name: Ayan A.
  full_name: Zhumekenov, Ayan A.
  last_name: Zhumekenov
- first_name: Osman M.
  full_name: Bakr, Osman M.
  last_name: Bakr
- first_name: Mikhail
  full_name: Lemeshko, Mikhail
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
- first_name: Zhanybek
  full_name: Alpichshev, Zhanybek
  id: 45E67A2A-F248-11E8-B48F-1D18A9856A87
  last_name: Alpichshev
  orcid: 0000-0002-7183-5203
citation:
  ama: Volosniev A, Shiva Kumar A, Lorenc D, et al. Spin-electric coupling in lead
    halide perovskites. <i>Physical Review Letters</i>. 2023;130(10). doi:<a href="https://doi.org/10.1103/physrevlett.130.106901">10.1103/physrevlett.130.106901</a>
  apa: Volosniev, A., Shiva Kumar, A., Lorenc, D., Ashourishokri, Y., Zhumekenov,
    A. A., Bakr, O. M., … Alpichshev, Z. (2023). Spin-electric coupling in lead halide
    perovskites. <i>Physical Review Letters</i>. American Physical Society. <a href="https://doi.org/10.1103/physrevlett.130.106901">https://doi.org/10.1103/physrevlett.130.106901</a>
  chicago: Volosniev, Artem, Abhishek Shiva Kumar, Dusan Lorenc, Younes Ashourishokri,
    Ayan A. Zhumekenov, Osman M. Bakr, Mikhail Lemeshko, and Zhanybek Alpichshev.
    “Spin-Electric Coupling in Lead Halide Perovskites.” <i>Physical Review Letters</i>.
    American Physical Society, 2023. <a href="https://doi.org/10.1103/physrevlett.130.106901">https://doi.org/10.1103/physrevlett.130.106901</a>.
  ieee: A. Volosniev <i>et al.</i>, “Spin-electric coupling in lead halide perovskites,”
    <i>Physical Review Letters</i>, vol. 130, no. 10. American Physical Society, 2023.
  ista: Volosniev A, Shiva Kumar A, Lorenc D, Ashourishokri Y, Zhumekenov AA, Bakr
    OM, Lemeshko M, Alpichshev Z. 2023. Spin-electric coupling in lead halide perovskites.
    Physical Review Letters. 130(10), 106901.
  mla: Volosniev, Artem, et al. “Spin-Electric Coupling in Lead Halide Perovskites.”
    <i>Physical Review Letters</i>, vol. 130, no. 10, 106901, American Physical Society,
    2023, doi:<a href="https://doi.org/10.1103/physrevlett.130.106901">10.1103/physrevlett.130.106901</a>.
  short: A. Volosniev, A. Shiva Kumar, D. Lorenc, Y. Ashourishokri, A.A. Zhumekenov,
    O.M. Bakr, M. Lemeshko, Z. Alpichshev, Physical Review Letters 130 (2023).
corr_author: '1'
date_created: 2023-03-14T13:11:59Z
date_published: 2023-03-10T00:00:00Z
date_updated: 2025-04-23T08:53:33Z
day: '10'
department:
- _id: GradSch
- _id: ZhAl
- _id: MiLe
doi: 10.1103/physrevlett.130.106901
external_id:
  arxiv:
  - '2203.09443'
  isi:
  - '000982435900002'
  pmid:
  - '36962044'
intvolume: '       130'
isi: 1
issue: '10'
keyword:
- General Physics and Astronomy
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2203.09443
month: '03'
oa: 1
oa_version: Preprint
pmid: 1
publication: Physical Review Letters
publication_identifier:
  eissn:
  - 1079-7114
  issn:
  - 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Spin-electric coupling in lead halide perovskites
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 130
year: '2023'
...
---
_id: '12724'
abstract:
- lang: eng
  text: 'We use general symmetry-based arguments to construct an effective model suitable
    for studying optical properties of lead halide perovskites. To build the model,
    we identify an atomic-level interaction between electromagnetic fields and the
    spin degree of freedom that should be added to a minimally coupled k⋅p Hamiltonian.
    As a first application, we study two basic optical characteristics of the material:
    the Verdet constant and the refractive index. Beyond these linear characteristics
    of the material, the model is suitable for calculating nonlinear effects such
    as the third-order optical susceptibility. Analysis of this quantity shows that
    the geometrical properties of the spin-electric term imply isotropic optical response
    of the system, and that optical anisotropy of lead halide perovskites is a manifestation
    of hopping of charge carriers. To illustrate this, we discuss third-harmonic generation.'
article_number: '125201'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Artem
  full_name: Volosniev, Artem
  id: 37D278BC-F248-11E8-B48F-1D18A9856A87
  last_name: Volosniev
  orcid: 0000-0003-0393-5525
- first_name: Abhishek
  full_name: Shiva Kumar, Abhishek
  id: 5e9a6931-eb97-11eb-a6c2-e96f7058d77a
  last_name: Shiva Kumar
- first_name: Dusan
  full_name: Lorenc, Dusan
  id: 40D8A3E6-F248-11E8-B48F-1D18A9856A87
  last_name: Lorenc
- first_name: Younes
  full_name: Ashourishokri, Younes
  id: e32c111f-f6e0-11ea-865d-eb955baea334
  last_name: Ashourishokri
- first_name: Ayan
  full_name: Zhumekenov, Ayan
  last_name: Zhumekenov
- first_name: Osman M.
  full_name: Bakr, Osman M.
  last_name: Bakr
- first_name: Mikhail
  full_name: Lemeshko, Mikhail
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
- first_name: Zhanybek
  full_name: Alpichshev, Zhanybek
  id: 45E67A2A-F248-11E8-B48F-1D18A9856A87
  last_name: Alpichshev
  orcid: 0000-0002-7183-5203
citation:
  ama: Volosniev A, Shiva Kumar A, Lorenc D, et al. Effective model for studying optical
    properties of lead halide perovskites. <i>Physical Review B</i>. 2023;107(12).
    doi:<a href="https://doi.org/10.1103/physrevb.107.125201">10.1103/physrevb.107.125201</a>
  apa: Volosniev, A., Shiva Kumar, A., Lorenc, D., Ashourishokri, Y., Zhumekenov,
    A., Bakr, O. M., … Alpichshev, Z. (2023). Effective model for studying optical
    properties of lead halide perovskites. <i>Physical Review B</i>. American Physical
    Society. <a href="https://doi.org/10.1103/physrevb.107.125201">https://doi.org/10.1103/physrevb.107.125201</a>
  chicago: Volosniev, Artem, Abhishek Shiva Kumar, Dusan Lorenc, Younes Ashourishokri,
    Ayan Zhumekenov, Osman M. Bakr, Mikhail Lemeshko, and Zhanybek Alpichshev. “Effective
    Model for Studying Optical Properties of Lead Halide Perovskites.” <i>Physical
    Review B</i>. American Physical Society, 2023. <a href="https://doi.org/10.1103/physrevb.107.125201">https://doi.org/10.1103/physrevb.107.125201</a>.
  ieee: A. Volosniev <i>et al.</i>, “Effective model for studying optical properties
    of lead halide perovskites,” <i>Physical Review B</i>, vol. 107, no. 12. American
    Physical Society, 2023.
  ista: Volosniev A, Shiva Kumar A, Lorenc D, Ashourishokri Y, Zhumekenov A, Bakr
    OM, Lemeshko M, Alpichshev Z. 2023. Effective model for studying optical properties
    of lead halide perovskites. Physical Review B. 107(12), 125201.
  mla: Volosniev, Artem, et al. “Effective Model for Studying Optical Properties of
    Lead Halide Perovskites.” <i>Physical Review B</i>, vol. 107, no. 12, 125201,
    American Physical Society, 2023, doi:<a href="https://doi.org/10.1103/physrevb.107.125201">10.1103/physrevb.107.125201</a>.
  short: A. Volosniev, A. Shiva Kumar, D. Lorenc, Y. Ashourishokri, A. Zhumekenov,
    O.M. Bakr, M. Lemeshko, Z. Alpichshev, Physical Review B 107 (2023).
corr_author: '1'
date_created: 2023-03-14T13:13:05Z
date_published: 2023-03-15T00:00:00Z
date_updated: 2024-10-09T21:04:46Z
day: '15'
department:
- _id: GradSch
- _id: ZhAl
- _id: MiLe
doi: 10.1103/physrevb.107.125201
external_id:
  arxiv:
  - '2204.04022'
  isi:
  - '000972602200006'
intvolume: '       107'
isi: 1
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2204.04022
month: '03'
oa: 1
oa_version: Preprint
publication: Physical Review B
publication_identifier:
  eissn:
  - 2469-9969
  issn:
  - 2469-9950
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Effective model for studying optical properties of lead halide perovskites
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 107
year: '2023'
...
---
_id: '12735'
abstract:
- lang: eng
  text: "Asynchronous programming has gained significant popularity over the last
    decade: support for this programming pattern is available in many popular languages
    via libraries and native language implementations, typically in the form of coroutines
    or the async/await construct. Instead of programming via shared memory, this concept
    assumes implicit synchronization through message passing. The key data structure
    enabling such communication is the rendezvous channel. Roughly, a rendezvous channel
    is a blocking queue of size zero, so both send(e) and receive() operations wait
    for each other, performing a rendezvous when they meet. To optimize the message
    passing pattern, channels are usually equipped with a fixed-size buffer, so sends
    do not suspend and put elements into the buffer until its capacity is exceeded.
    This primitive is known as a buffered channel.\r\n\r\nThis paper presents a fast
    and scalable algorithm for both rendezvous and buffered channels. Similarly to
    modern queues, our solution is based on an infinite array with two positional
    counters for send(e) and receive() operations, leveraging the unconditional Fetch-And-Add
    instruction to update them. Yet, the algorithm requires non-trivial modifications
    of this classic pattern, in order to support the full channel semantics, such
    as buffering and cancellation of waiting requests. We compare the performance
    of our solution to that of the Kotlin implementation, as well as against other
    academic proposals, showing up to 9.8× speedup. To showcase its expressiveness
    and performance, we also integrated the proposed algorithm into the standard Kotlin
    Coroutines library, replacing the previous channel implementations."
article_processing_charge: No
arxiv: 1
author:
- first_name: Nikita
  full_name: Koval, Nikita
  id: 2F4DB10C-F248-11E8-B48F-1D18A9856A87
  last_name: Koval
- first_name: Dan-Adrian
  full_name: Alistarh, Dan-Adrian
  id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
  last_name: Alistarh
  orcid: 0000-0003-3650-940X
- first_name: Roman
  full_name: Elizarov, Roman
  last_name: Elizarov
citation:
  ama: 'Koval N, Alistarh D-A, Elizarov R. Fast and scalable channels in Kotlin Coroutines.
    In: <i>Proceedings of the ACM SIGPLAN Symposium on Principles and Practice of
    Parallel Programming</i>. Association for Computing Machinery; 2023:107-118. doi:<a
    href="https://doi.org/10.1145/3572848.3577481">10.1145/3572848.3577481</a>'
  apa: 'Koval, N., Alistarh, D.-A., &#38; Elizarov, R. (2023). Fast and scalable channels
    in Kotlin Coroutines. In <i>Proceedings of the ACM SIGPLAN Symposium on Principles
    and Practice of Parallel Programming</i> (pp. 107–118). Montreal, QC, Canada:
    Association for Computing Machinery. <a href="https://doi.org/10.1145/3572848.3577481">https://doi.org/10.1145/3572848.3577481</a>'
  chicago: Koval, Nikita, Dan-Adrian Alistarh, and Roman Elizarov. “Fast and Scalable
    Channels in Kotlin Coroutines.” In <i>Proceedings of the ACM SIGPLAN Symposium
    on Principles and Practice of Parallel Programming</i>, 107–18. Association for
    Computing Machinery, 2023. <a href="https://doi.org/10.1145/3572848.3577481">https://doi.org/10.1145/3572848.3577481</a>.
  ieee: N. Koval, D.-A. Alistarh, and R. Elizarov, “Fast and scalable channels in
    Kotlin Coroutines,” in <i>Proceedings of the ACM SIGPLAN Symposium on Principles
    and Practice of Parallel Programming</i>, Montreal, QC, Canada, 2023, pp. 107–118.
  ista: 'Koval N, Alistarh D-A, Elizarov R. 2023. Fast and scalable channels in Kotlin
    Coroutines. Proceedings of the ACM SIGPLAN Symposium on Principles and Practice
    of Parallel Programming. PPoPP: Sympopsium on Principles and Practice of Parallel
    Programming, 107–118.'
  mla: Koval, Nikita, et al. “Fast and Scalable Channels in Kotlin Coroutines.” <i>Proceedings
    of the ACM SIGPLAN Symposium on Principles and Practice of Parallel Programming</i>,
    Association for Computing Machinery, 2023, pp. 107–18, doi:<a href="https://doi.org/10.1145/3572848.3577481">10.1145/3572848.3577481</a>.
  short: N. Koval, D.-A. Alistarh, R. Elizarov, in:, Proceedings of the ACM SIGPLAN
    Symposium on Principles and Practice of Parallel Programming, Association for
    Computing Machinery, 2023, pp. 107–118.
conference:
  end_date: 2023-03-01
  location: Montreal, QC, Canada
  name: 'PPoPP: Sympopsium on Principles and Practice of Parallel Programming'
  start_date: 2023-02-25
date_created: 2023-03-19T23:00:58Z
date_published: 2023-02-25T00:00:00Z
date_updated: 2023-03-20T07:29:28Z
day: '25'
department:
- _id: DaAl
doi: 10.1145/3572848.3577481
external_id:
  arxiv:
  - '2211.04986'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2211.04986
month: '02'
oa: 1
oa_version: Preprint
page: 107-118
publication: Proceedings of the ACM SIGPLAN Symposium on Principles and Practice of
  Parallel Programming
publication_identifier:
  isbn:
  - '9798400700156'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fast and scalable channels in Kotlin Coroutines
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12736'
abstract:
- lang: eng
  text: Although a wide variety of handcrafted concurrent data structures have been
    proposed, there is considerable interest in universal approaches (Universal Constructions
    or UCs) for building concurrent data structures. UCs (semi-)automatically convert
    a sequential data structure into a concurrent one. The simplest approach uses
    locks [3, 6] that protect a sequential data structure and allow only one process
    to access it at a time. However, the resulting data structure is blocking. Most
    work on UCs instead focuses on obtaining non-blocking progress guarantees such
    as obstruction-freedom, lock-freedom or wait-freedom. Many non-blocking UCs have
    appeared. Key examples include the seminal wait-free UC [2] by Herlihy, a NUMA-aware
    UC [10] by Yi et al., and an efficient UC for large objects [1] by Fatourou et
    al.
acknowledgement: 'This work was supported by: the Natural Sciences and Engineering
  Research Council of Canada (NSERC) Discovery Program grant: RGPIN-2019-04227, and
  the Canada Foundation for Innovation John R. Evans Leaders Fund (CFI-JELF) with
  equal support from the Ontario Research Fund CFI Leaders Opportunity Fund: 38512.'
article_processing_charge: No
author:
- first_name: Vitaly
  full_name: Aksenov, Vitaly
  last_name: Aksenov
- first_name: Trevor A
  full_name: Brown, Trevor A
  id: 3569F0A0-F248-11E8-B48F-1D18A9856A87
  last_name: Brown
- first_name: Alexander
  full_name: Fedorov, Alexander
  id: 2e711909-896a-11ed-bdf8-eb0f5a2984c6
  last_name: Fedorov
- first_name: Ilya
  full_name: Kokorin, Ilya
  last_name: Kokorin
citation:
  ama: Aksenov V, Brown TA, Fedorov A, Kokorin I. <i>Unexpected Scaling in Path Copying
    Trees</i>. Association for Computing Machinery; 2023:438-440. doi:<a href="https://doi.org/10.1145/3572848.3577512">10.1145/3572848.3577512</a>
  apa: 'Aksenov, V., Brown, T. A., Fedorov, A., &#38; Kokorin, I. (2023). <i>Unexpected
    scaling in path copying trees</i>. <i>Proceedings of the ACM SIGPLAN Symposium
    on Principles and Practice of Parallel Programming</i> (pp. 438–440). Montreal,
    QB, Canada: Association for Computing Machinery. <a href="https://doi.org/10.1145/3572848.3577512">https://doi.org/10.1145/3572848.3577512</a>'
  chicago: Aksenov, Vitaly, Trevor A Brown, Alexander Fedorov, and Ilya Kokorin. <i>Unexpected
    Scaling in Path Copying Trees</i>. <i>Proceedings of the ACM SIGPLAN Symposium
    on Principles and Practice of Parallel Programming</i>. Association for Computing
    Machinery, 2023. <a href="https://doi.org/10.1145/3572848.3577512">https://doi.org/10.1145/3572848.3577512</a>.
  ieee: V. Aksenov, T. A. Brown, A. Fedorov, and I. Kokorin, <i>Unexpected scaling
    in path copying trees</i>. Association for Computing Machinery, 2023, pp. 438–440.
  ista: Aksenov V, Brown TA, Fedorov A, Kokorin I. 2023. Unexpected scaling in path
    copying trees, Association for Computing Machinery,p.
  mla: Aksenov, Vitaly, et al. “Unexpected Scaling in Path Copying Trees.” <i>Proceedings
    of the ACM SIGPLAN Symposium on Principles and Practice of Parallel Programming</i>,
    Association for Computing Machinery, 2023, pp. 438–40, doi:<a href="https://doi.org/10.1145/3572848.3577512">10.1145/3572848.3577512</a>.
  short: V. Aksenov, T.A. Brown, A. Fedorov, I. Kokorin, Unexpected Scaling in Path
    Copying Trees, Association for Computing Machinery, 2023.
conference:
  end_date: 2023-03-01
  location: Montreal, QB, Canada
  name: 'PPoPP: Sympopsium on Principles and Practice of Parallel Programming'
  start_date: 2023-02-25
date_created: 2023-03-19T23:00:58Z
date_published: 2023-02-25T00:00:00Z
date_updated: 2024-10-21T06:01:21Z
day: '25'
department:
- _id: DaAl
- _id: GradSch
doi: 10.1145/3572848.3577512
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1145/3572848.3577512
month: '02'
oa: 1
oa_version: Published Version
page: 438-440
publication: Proceedings of the ACM SIGPLAN Symposium on Principles and Practice of
  Parallel Programming
publication_identifier:
  isbn:
  - '9798400700156'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Unexpected scaling in path copying trees
type: conference_poster
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
OA_place: repository
OA_type: green
_id: '12737'
abstract:
- lang: eng
  text: The substitution of heavier, more metallic atoms into classical organic ligand
    frameworks provides an important strategy for tuning ligand properties, such as
    ligand bite and donor character, and is the basis for the emerging area of main-group
    supramolecular chemistry. In this paper, we explore two new ligands [E(2-Me-8-qy)3]
    [E = Sb (1), Bi (2); qy = quinolyl], allowing a fundamental comparison of their
    coordination behavior with classical tris(2-pyridyl) ligands of the type [E′(2-py)3]
    (E = a range of bridgehead atoms and groups, py = pyridyl). A range of new coordination
    modes to Cu+, Ag+, and Au+ is seen for 1 and 2, in the absence of steric constraints
    at the bridgehead and with their more remote N-donor atoms. A particular feature
    is the adaptive nature of these new ligands, with the ability to adjust coordination
    mode in response to the hard–soft character of coordinated metal ions, influenced
    also by the character of the bridgehead atom (Sb or Bi). These features can be
    seen in a comparison between [Cu2{Sb(2-Me-8-qy)3}2](PF6)2 (1·CuPF6) and [Cu{Bi(2-Me-8-qy)3}](PF6)
    (2·CuPF6), the first containing a dimeric cation in which 1 adopts an unprecedented
    intramolecular N,N,Sb-coordination mode while in the second, 2 adopts an unusual
    N,N,(π-)C coordination mode. In contrast, the previously reported analogous ligands
    [E(6-Me-2-py)3] (E = Sb, Bi; 2-py = 2-pyridyl) show a tris-chelating mode in their
    complexes with CuPF6, which is typical for the extensive tris(2-pyridyl) family
    with a range of metals. The greater polarity of the Bi–C bond in 2 results in
    ligand transfer reactions with Au(I). Although this reactivity is not in itself
    unusual, the characterization of several products by single-crystal X-ray diffraction
    provides snapshots of the ligand transfer reaction involved, with one of the products
    (the bimetallic complex [(BiCl){ClAu2(2-Me-8-qy)3}] (8)) containing a Au2Bi core
    in which the shortest Au → Bi donor–acceptor bond to date is observed.
acknowledgement: The authors thank the Walters-Kundert Studentship of Selwyn College
  (scholarship for J.E.W.), the Leverhulme Trust (R.G.-R. and D.S.W., grant RPG-2017-146),
  the Australian Research Council (A.L.C., DE200100450), the Spanish Ministry of Science
  and Innovation (MCI) and the Spanish Ministry of Science, Innovation and Universities
  (MCIU) (R.G.-R., PID2021-124691NB-I00, funded by MCIN/AEI/10.13039/501100011033/FEDER,
  UE and PGC2018-096880-A-I00, MCIU/AEI/FEDER), The University of Valladolid and Santander
  Bank (Fellowship for A.G.-R.), and the U.K. EPSRC and The Royal Dutch Shell plc.
  (I-Case award for R.B.J., EP/R511870/1) for financial support. Calculations were
  carried out on an in-house Odyssey HPC cluster (Cambridge), and the authors are
  grateful for the calculation time used.
article_processing_charge: No
article_type: original
author:
- first_name: Álvaro
  full_name: García-Romero, Álvaro
  last_name: García-Romero
- first_name: Jessica E.
  full_name: Waters, Jessica E.
  last_name: Waters
- first_name: Rajesh B
  full_name: Jethwa, Rajesh B
  id: 4cc538d5-803f-11ed-ab7e-8139573aad8f
  last_name: Jethwa
  orcid: 0000-0002-0404-4356
- first_name: Andrew D.
  full_name: Bond, Andrew D.
  last_name: Bond
- first_name: Annie L.
  full_name: Colebatch, Annie L.
  last_name: Colebatch
- first_name: Raúl
  full_name: García-Rodríguez, Raúl
  last_name: García-Rodríguez
- first_name: Dominic S.
  full_name: Wright, Dominic S.
  last_name: Wright
citation:
  ama: García-Romero Á, Waters JE, Jethwa RB, et al. Highly adaptive nature of group
    15 tris(quinolyl) ligands─studies with coinage metals. <i>Inorganic Chemistry</i>.
    2023;62(11):4625-4636. doi:<a href="https://doi.org/10.1021/acs.inorgchem.3c00057">10.1021/acs.inorgchem.3c00057</a>
  apa: García-Romero, Á., Waters, J. E., Jethwa, R. B., Bond, A. D., Colebatch, A.
    L., García-Rodríguez, R., &#38; Wright, D. S. (2023). Highly adaptive nature of
    group 15 tris(quinolyl) ligands─studies with coinage metals. <i>Inorganic Chemistry</i>.
    American Chemical Society. <a href="https://doi.org/10.1021/acs.inorgchem.3c00057">https://doi.org/10.1021/acs.inorgchem.3c00057</a>
  chicago: García-Romero, Álvaro, Jessica E. Waters, Rajesh B Jethwa, Andrew D. Bond,
    Annie L. Colebatch, Raúl García-Rodríguez, and Dominic S. Wright. “Highly Adaptive
    Nature of Group 15 Tris(Quinolyl) Ligands─studies with Coinage Metals.” <i>Inorganic
    Chemistry</i>. American Chemical Society, 2023. <a href="https://doi.org/10.1021/acs.inorgchem.3c00057">https://doi.org/10.1021/acs.inorgchem.3c00057</a>.
  ieee: Á. García-Romero <i>et al.</i>, “Highly adaptive nature of group 15 tris(quinolyl)
    ligands─studies with coinage metals,” <i>Inorganic Chemistry</i>, vol. 62, no.
    11. American Chemical Society, pp. 4625–4636, 2023.
  ista: García-Romero Á, Waters JE, Jethwa RB, Bond AD, Colebatch AL, García-Rodríguez
    R, Wright DS. 2023. Highly adaptive nature of group 15 tris(quinolyl) ligands─studies
    with coinage metals. Inorganic Chemistry. 62(11), 4625–4636.
  mla: García-Romero, Álvaro, et al. “Highly Adaptive Nature of Group 15 Tris(Quinolyl)
    Ligands─studies with Coinage Metals.” <i>Inorganic Chemistry</i>, vol. 62, no.
    11, American Chemical Society, 2023, pp. 4625–36, doi:<a href="https://doi.org/10.1021/acs.inorgchem.3c00057">10.1021/acs.inorgchem.3c00057</a>.
  short: Á. García-Romero, J.E. Waters, R.B. Jethwa, A.D. Bond, A.L. Colebatch, R.
    García-Rodríguez, D.S. Wright, Inorganic Chemistry 62 (2023) 4625–4636.
date_created: 2023-03-19T23:00:59Z
date_published: 2023-03-08T00:00:00Z
date_updated: 2025-04-24T11:32:09Z
day: '08'
department:
- _id: StFr
doi: 10.1021/acs.inorgchem.3c00057
external_id:
  isi:
  - '000956110300001'
  pmid:
  - '36883367'
intvolume: '        62'
isi: 1
issue: '11'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://uvadoc.uva.es/handle/10324/59798
month: '03'
oa: 1
oa_version: Submitted Version
page: 4625-4636
pmid: 1
publication: Inorganic Chemistry
publication_identifier:
  eissn:
  - 1520-510X
  issn:
  - 0020-1669
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Highly adaptive nature of group 15 tris(quinolyl) ligands─studies with coinage
  metals
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 62
year: '2023'
...
---
_id: '12747'
abstract:
- lang: eng
  text: Muscle degeneration is the most prevalent cause for frailty and dependency
    in inherited diseases and ageing. Elucidation of pathophysiological mechanisms,
    as well as effective treatments for muscle diseases, represents an important goal
    in improving human health. Here, we show that the lipid synthesis enzyme phosphatidylethanolamine
    cytidyltransferase (PCYT2/ECT) is critical to muscle health. Human deficiency
    in PCYT2 causes a severe disease with failure to thrive and progressive weakness.
    pcyt2-mutant zebrafish and muscle-specific Pcyt2-knockout mice recapitulate the
    participant phenotypes, with failure to thrive, progressive muscle weakness and
    accelerated ageing. Mechanistically, muscle Pcyt2 deficiency affects cellular
    bioenergetics and membrane lipid bilayer structure and stability. PCYT2 activity
    declines in ageing muscles of mice and humans, and adeno-associated virus-based
    delivery of PCYT2 ameliorates muscle weakness in Pcyt2-knockout and old mice,
    offering a therapy for individuals with a rare disease and muscle ageing. Thus,
    PCYT2 plays a fundamental and conserved role in vertebrate muscle health, linking
    PCYT2 and PCYT2-synthesized lipids to severe muscle dystrophy and ageing.
acknowledgement: 'The authors thank the participants and their families for participating
  in the study. We thank all members of our laboratories for helpful discussions.
  We are grateful to Vienna BioCenter Core Facilities: Mouse Phenotyping Unit, Histopathology
  Unit, Bioinformatics Unit, BioOptics Unit, Electron Microscopy Unit and Comparative
  Medicine Unit. We are grateful to the Lipidomics Facility, and K. Klavins and T.
  Hannich at the CeMM Research Center for Molecular Medicine of the Austrian Academy
  of Sciences for assistance with lipidomics analysis. We also thank T. Huan and A.
  Hui (UBC Vancouver) for mouse tissue and mitochondria lipidomics analysis. We thank
  A. Klymchenko (Laboratoire de Bioimagerie et Pathologies Université de Strasbourg,
  Strasbourg, France) for providing the NR12S probe. We are thankful to the Sen. Paul
  D. Wellstone Muscular Dystrophy Cooperative Specialized Research Center Viral Vector
  Core Facility for AAV6 production. We also thank K. P. Campbell and M. E. Anderson
  (University of Iowa, Carver College of Medicine) for advice on muscle tissue handling.
  We thank A. Al-Qassabi from the Sultan Qaboos University for the clinical assessment
  of the participants. D.C. and J.M.P. are supported by the Austrian Federal Ministry
  of Education, Science and Research, the Austrian Academy of Sciences, and the City
  of Vienna, and grants from the Austrian Science Fund (FWF) Wittgenstein award (Z
  271-B19), the T. von Zastrow Foundation, and a Canada 150 Research Chairs Program
  (F18-01336). J.S.C. is supported by grants RO1AR44533 and P50AR065139 from the US
  National Institutes of Health. C.K. is supported by a grant from the Agence Nationale
  de la Recherche (ANR-18-CE14-0007-01). A.V.K. is supported by European Union’s Horizon
  2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement
  no. 67544, and an Austrian Science Fund (FWF; no P-33799). A.W. is supported by
  Austrian Research Promotion Agency (FFG) project no 867674. E.S. is supported by
  a SciLifeLab fellowship and Karolinska Institutet Foundation Grants. Work in the
  laboratory of G.S.-F. is supported by the Austrian Academy of Sciences, the European
  Research Council (ERC AdG 695214 GameofGates) and the Innovative Medicines Initiative
  2 Joint Undertaking (grant agreement no. 777372, ReSOLUTE). S.B., M.L. and R.Y.
  acknowledge the support of the Spastic Paraplegia Foundation.'
article_processing_charge: No
article_type: original
author:
- first_name: Domagoj
  full_name: Cikes, Domagoj
  last_name: Cikes
- first_name: Kareem
  full_name: Elsayad, Kareem
  last_name: Elsayad
- first_name: Erdinc
  full_name: Sezgin, Erdinc
  last_name: Sezgin
- first_name: Erika
  full_name: Koitai, Erika
  last_name: Koitai
- first_name: Torma
  full_name: Ferenc, Torma
  last_name: Ferenc
- first_name: Michael
  full_name: Orthofer, Michael
  last_name: Orthofer
- first_name: Rebecca
  full_name: Yarwood, Rebecca
  last_name: Yarwood
- first_name: Leonhard X.
  full_name: Heinz, Leonhard X.
  last_name: Heinz
- first_name: Vitaly
  full_name: Sedlyarov, Vitaly
  last_name: Sedlyarov
- first_name: Nasser
  full_name: Darwish-Miranda, Nasser
  id: 39CD9926-F248-11E8-B48F-1D18A9856A87
  last_name: Darwish-Miranda
  orcid: 0000-0002-8821-8236
- first_name: Adrian
  full_name: Taylor, Adrian
  last_name: Taylor
- first_name: Sophie
  full_name: Grapentine, Sophie
  last_name: Grapentine
- first_name: Fathiya
  full_name: al-Murshedi, Fathiya
  last_name: al-Murshedi
- first_name: Anne
  full_name: Abot, Anne
  last_name: Abot
- first_name: Adelheid
  full_name: Weidinger, Adelheid
  last_name: Weidinger
- first_name: Candice
  full_name: Kutchukian, Candice
  last_name: Kutchukian
- first_name: Colline
  full_name: Sanchez, Colline
  last_name: Sanchez
- first_name: Shane J. F.
  full_name: Cronin, Shane J. F.
  last_name: Cronin
- first_name: Maria
  full_name: Novatchkova, Maria
  last_name: Novatchkova
- first_name: Anoop
  full_name: Kavirayani, Anoop
  last_name: Kavirayani
- first_name: Thomas
  full_name: Schuetz, Thomas
  last_name: Schuetz
- first_name: Bernhard
  full_name: Haubner, Bernhard
  last_name: Haubner
- first_name: Lisa
  full_name: Haas, Lisa
  last_name: Haas
- first_name: Astrid
  full_name: Hagelkruys, Astrid
  last_name: Hagelkruys
- first_name: Suzanne
  full_name: Jackowski, Suzanne
  last_name: Jackowski
- first_name: Andrey
  full_name: Kozlov, Andrey
  last_name: Kozlov
- first_name: Vincent
  full_name: Jacquemond, Vincent
  last_name: Jacquemond
- first_name: Claude
  full_name: Knauf, Claude
  last_name: Knauf
- first_name: Giulio
  full_name: Superti-Furga, Giulio
  last_name: Superti-Furga
- first_name: Eric
  full_name: Rullman, Eric
  last_name: Rullman
- first_name: Thomas
  full_name: Gustafsson, Thomas
  last_name: Gustafsson
- first_name: John
  full_name: McDermot, John
  last_name: McDermot
- first_name: Martin
  full_name: Lowe, Martin
  last_name: Lowe
- first_name: Zsolt
  full_name: Radak, Zsolt
  last_name: Radak
- first_name: Jeffrey S.
  full_name: Chamberlain, Jeffrey S.
  last_name: Chamberlain
- first_name: Marica
  full_name: Bakovic, Marica
  last_name: Bakovic
- first_name: Siddharth
  full_name: Banka, Siddharth
  last_name: Banka
- first_name: Josef M.
  full_name: Penninger, Josef M.
  last_name: Penninger
citation:
  ama: Cikes D, Elsayad K, Sezgin E, et al. PCYT2-regulated lipid biosynthesis is
    critical to muscle health and ageing. <i>Nature Metabolism</i>. 2023;5:495-515.
    doi:<a href="https://doi.org/10.1038/s42255-023-00766-2">10.1038/s42255-023-00766-2</a>
  apa: Cikes, D., Elsayad, K., Sezgin, E., Koitai, E., Ferenc, T., Orthofer, M., …
    Penninger, J. M. (2023). PCYT2-regulated lipid biosynthesis is critical to muscle
    health and ageing. <i>Nature Metabolism</i>. Springer Nature. <a href="https://doi.org/10.1038/s42255-023-00766-2">https://doi.org/10.1038/s42255-023-00766-2</a>
  chicago: Cikes, Domagoj, Kareem Elsayad, Erdinc Sezgin, Erika Koitai, Torma Ferenc,
    Michael Orthofer, Rebecca Yarwood, et al. “PCYT2-Regulated Lipid Biosynthesis
    Is Critical to Muscle Health and Ageing.” <i>Nature Metabolism</i>. Springer Nature,
    2023. <a href="https://doi.org/10.1038/s42255-023-00766-2">https://doi.org/10.1038/s42255-023-00766-2</a>.
  ieee: D. Cikes <i>et al.</i>, “PCYT2-regulated lipid biosynthesis is critical to
    muscle health and ageing,” <i>Nature Metabolism</i>, vol. 5. Springer Nature,
    pp. 495–515, 2023.
  ista: Cikes D, Elsayad K, Sezgin E, Koitai E, Ferenc T, Orthofer M, Yarwood R, Heinz
    LX, Sedlyarov V, Darwish-Miranda N, Taylor A, Grapentine S, al-Murshedi F, Abot
    A, Weidinger A, Kutchukian C, Sanchez C, Cronin SJF, Novatchkova M, Kavirayani
    A, Schuetz T, Haubner B, Haas L, Hagelkruys A, Jackowski S, Kozlov A, Jacquemond
    V, Knauf C, Superti-Furga G, Rullman E, Gustafsson T, McDermot J, Lowe M, Radak
    Z, Chamberlain JS, Bakovic M, Banka S, Penninger JM. 2023. PCYT2-regulated lipid
    biosynthesis is critical to muscle health and ageing. Nature Metabolism. 5, 495–515.
  mla: Cikes, Domagoj, et al. “PCYT2-Regulated Lipid Biosynthesis Is Critical to Muscle
    Health and Ageing.” <i>Nature Metabolism</i>, vol. 5, Springer Nature, 2023, pp.
    495–515, doi:<a href="https://doi.org/10.1038/s42255-023-00766-2">10.1038/s42255-023-00766-2</a>.
  short: D. Cikes, K. Elsayad, E. Sezgin, E. Koitai, T. Ferenc, M. Orthofer, R. Yarwood,
    L.X. Heinz, V. Sedlyarov, N. Darwish-Miranda, A. Taylor, S. Grapentine, F. al-Murshedi,
    A. Abot, A. Weidinger, C. Kutchukian, C. Sanchez, S.J.F. Cronin, M. Novatchkova,
    A. Kavirayani, T. Schuetz, B. Haubner, L. Haas, A. Hagelkruys, S. Jackowski, A.
    Kozlov, V. Jacquemond, C. Knauf, G. Superti-Furga, E. Rullman, T. Gustafsson,
    J. McDermot, M. Lowe, Z. Radak, J.S. Chamberlain, M. Bakovic, S. Banka, J.M. Penninger,
    Nature Metabolism 5 (2023) 495–515.
date_created: 2023-03-23T12:58:43Z
date_published: 2023-03-20T00:00:00Z
date_updated: 2023-11-28T07:31:33Z
day: '20'
department:
- _id: Bio
doi: 10.1038/s42255-023-00766-2
external_id:
  isi:
  - '000992064000002'
  pmid:
  - '36941451'
intvolume: '         5'
isi: 1
keyword:
- Cell Biology
- Physiology (medical)
- Endocrinology
- Diabetes and Metabolism
- Internal Medicine
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/2022.03.02.482658
month: '03'
oa: 1
oa_version: Preprint
page: 495-515
pmid: 1
publication: Nature Metabolism
publication_identifier:
  issn:
  - 2522-5812
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - relation: erratum
    url: https://doi.org/10.1038/s42255-023-00791-1
scopus_import: '1'
status: public
title: PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2023'
...
---
_id: '12756'
abstract:
- lang: eng
  text: ESCRT-III family proteins form composite polymers that deform and cut membrane
    tubes in the context of a wide range of cell biological processes across the tree
    of life. In reconstituted systems, sequential changes in the composition of ESCRT-III
    polymers induced by the AAA–adenosine triphosphatase Vps4 have been shown to remodel
    membranes. However, it is not known how composite ESCRT-III polymers are organized
    and remodeled in space and time in a cellular context. Taking advantage of the
    relative simplicity of the ESCRT-III–dependent division system in Sulfolobus acidocaldarius,
    one of the closest experimentally tractable prokaryotic relatives of eukaryotes,
    we use super-resolution microscopy, electron microscopy, and computational modeling
    to show how CdvB/CdvB1/CdvB2 proteins form a precisely patterned composite ESCRT-III
    division ring, which undergoes stepwise Vps4-dependent disassembly and contracts
    to cut cells into two. These observations lead us to suggest sequential changes
    in a patterned composite polymer as a general mechanism of ESCRT-III–dependent
    membrane remodeling.
acknowledgement: "We thank Y. Liu and V. Hale for help with electron cryotomography;
  the Medical Research Council (MRC) LMB Electron Microscopy Facility for access,
  training, and support; and T. Darling and J. Grimmett at the MRC LMB for help with
  computing infrastructure. We also thank the Flow Cytometry Facility and the MRC
  LMB for training and support.\r\n F.H. and G.T.-R. were supported by a grant from
  the Wellcome Trust (203276/Z/16/Z). A.C. was supported by an EMBO long-term fellowship:
  ALTF_1041-2021. J.T. was supported by a grant from the VW Foundation (94933). A.A.P.
  was supported by the Wellcome Trust (203276/Z/16/Z) and the HFSP (LT001027/2019).
  B.B. received support from the MRC LMB, the Wellcome Trust (203276/Z/16/Z), the
  VW Foundation (94933), the Life Sciences–Moore-Simons Foundation (735929LPI), and
  a Gordon and Betty Moore Foundation’s Symbiosis in Aquatic Systems Initiative (9346).
  A.Š. and X.J. acknowledge funding from the European Research Council (ERC) under
  the European Union’s Horizon 2020 research and innovation programme (grant no. 802960).
  L.H.-K. acknowledges support from Biotechnology and Biological Sciences Research
  Council LIDo Programme. T.N. and J.L. were supported by the MRC (U105184326) and
  the Wellcome Trust (203276/Z/16/Z)."
article_number: eade5224
article_processing_charge: No
article_type: original
author:
- first_name: Fredrik
  full_name: Hurtig, Fredrik
  last_name: Hurtig
- first_name: Thomas C.Q.
  full_name: Burgers, Thomas C.Q.
  last_name: Burgers
- first_name: Alice
  full_name: Cezanne, Alice
  last_name: Cezanne
- first_name: Xiuyun
  full_name: Jiang, Xiuyun
  last_name: Jiang
- first_name: Frank N.
  full_name: Mol, Frank N.
  last_name: Mol
- first_name: Jovan
  full_name: Traparić, Jovan
  last_name: Traparić
- first_name: Andre Arashiro
  full_name: Pulschen, Andre Arashiro
  last_name: Pulschen
- first_name: Tim
  full_name: Nierhaus, Tim
  last_name: Nierhaus
- first_name: Gabriel
  full_name: Tarrason-Risa, Gabriel
  last_name: Tarrason-Risa
- first_name: Lena
  full_name: Harker-Kirschneck, Lena
  last_name: Harker-Kirschneck
- first_name: Jan
  full_name: Löwe, Jan
  last_name: Löwe
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: Rifka
  full_name: Vlijm, Rifka
  last_name: Vlijm
- first_name: Buzz
  full_name: Baum, Buzz
  last_name: Baum
citation:
  ama: Hurtig F, Burgers TCQ, Cezanne A, et al. The patterned assembly and stepwise
    Vps4-mediated disassembly of composite ESCRT-III polymers drives archaeal cell
    division. <i>Science Advances</i>. 2023;9(11). doi:<a href="https://doi.org/10.1126/sciadv.ade5224">10.1126/sciadv.ade5224</a>
  apa: Hurtig, F., Burgers, T. C. Q., Cezanne, A., Jiang, X., Mol, F. N., Traparić,
    J., … Baum, B. (2023). The patterned assembly and stepwise Vps4-mediated disassembly
    of composite ESCRT-III polymers drives archaeal cell division. <i>Science Advances</i>.
    American Association for the Advancement of Science. <a href="https://doi.org/10.1126/sciadv.ade5224">https://doi.org/10.1126/sciadv.ade5224</a>
  chicago: Hurtig, Fredrik, Thomas C.Q. Burgers, Alice Cezanne, Xiuyun Jiang, Frank
    N. Mol, Jovan Traparić, Andre Arashiro Pulschen, et al. “The Patterned Assembly
    and Stepwise Vps4-Mediated Disassembly of Composite ESCRT-III Polymers Drives
    Archaeal Cell Division.” <i>Science Advances</i>. American Association for the
    Advancement of Science, 2023. <a href="https://doi.org/10.1126/sciadv.ade5224">https://doi.org/10.1126/sciadv.ade5224</a>.
  ieee: F. Hurtig <i>et al.</i>, “The patterned assembly and stepwise Vps4-mediated
    disassembly of composite ESCRT-III polymers drives archaeal cell division,” <i>Science
    Advances</i>, vol. 9, no. 11. American Association for the Advancement of Science,
    2023.
  ista: Hurtig F, Burgers TCQ, Cezanne A, Jiang X, Mol FN, Traparić J, Pulschen AA,
    Nierhaus T, Tarrason-Risa G, Harker-Kirschneck L, Löwe J, Šarić A, Vlijm R, Baum
    B. 2023. The patterned assembly and stepwise Vps4-mediated disassembly of composite
    ESCRT-III polymers drives archaeal cell division. Science Advances. 9(11), eade5224.
  mla: Hurtig, Fredrik, et al. “The Patterned Assembly and Stepwise Vps4-Mediated
    Disassembly of Composite ESCRT-III Polymers Drives Archaeal Cell Division.” <i>Science
    Advances</i>, vol. 9, no. 11, eade5224, American Association for the Advancement
    of Science, 2023, doi:<a href="https://doi.org/10.1126/sciadv.ade5224">10.1126/sciadv.ade5224</a>.
  short: F. Hurtig, T.C.Q. Burgers, A. Cezanne, X. Jiang, F.N. Mol, J. Traparić, A.A.
    Pulschen, T. Nierhaus, G. Tarrason-Risa, L. Harker-Kirschneck, J. Löwe, A. Šarić,
    R. Vlijm, B. Baum, Science Advances 9 (2023).
corr_author: '1'
date_created: 2023-03-26T22:01:06Z
date_published: 2023-03-17T00:00:00Z
date_updated: 2025-04-23T08:50:02Z
day: '17'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1126/sciadv.ade5224
ec_funded: 1
external_id:
  isi:
  - '000968083500010'
  pmid:
  - '36921039'
file:
- access_level: open_access
  checksum: 6d7dbe9ed86a116c8a002d62971202c5
  content_type: application/pdf
  creator: dernst
  date_created: 2023-03-27T06:24:49Z
  date_updated: 2023-03-27T06:24:49Z
  file_id: '12768'
  file_name: 2023_ScienceAdvances_Hurtig.pdf
  file_size: 1826471
  relation: main_file
  success: 1
file_date_updated: 2023-03-27T06:24:49Z
has_accepted_license: '1'
intvolume: '         9'
isi: 1
issue: '11'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
  call_identifier: H2020
  grant_number: '802960'
  name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
publication: Science Advances
publication_identifier:
  eissn:
  - 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: The patterned assembly and stepwise Vps4-mediated disassembly of composite
  ESCRT-III polymers drives archaeal cell division
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2023'
...
---
_id: '12757'
abstract:
- lang: eng
  text: My group and myself have studied respiratory complex I for almost 30 years,
    starting in 1994 when it was known as a L-shaped giant ‘black box' of bioenergetics.
    First breakthrough was the X-ray structure of the peripheral arm, followed by
    structures of the membrane arm and finally the entire complex from Thermus thermophilus.
    The developments in cryo-EM technology allowed us to solve the first complete
    structure of the twice larger, ∼1 MDa mammalian enzyme in 2016. However, the mechanism
    coupling, over large distances, the transfer of two electrons to pumping of four
    protons across the membrane remained an enigma. Recently we have solved high-resolution
    structures of mammalian and bacterial complex I under a range of redox conditions,
    including catalytic turnover. This allowed us to propose a robust and universal
    mechanism for complex I and related protein families. Redox reactions initially
    drive conformational changes around the quinone cavity and a long-distance transfer
    of substrate protons. These set up a stage for a series of electrostatically driven
    proton transfers along the membrane arm (‘domino effect'), eventually resulting
    in proton expulsion from the distal antiporter-like subunit. The mechanism radically
    differs from previous suggestions, however, it naturally explains all the unusual
    structural features of complex I. In this review I discuss the state of knowledge
    on complex I, including the current most controversial issues.
article_processing_charge: No
article_type: review
author:
- first_name: Leonid A
  full_name: Sazanov, Leonid A
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
citation:
  ama: 'Sazanov LA. From the “black box” to “domino effect” mechanism: What have we
    learned from the structures of respiratory complex I. <i>The Biochemical Journal</i>.
    2023;480(5):319-333. doi:<a href="https://doi.org/10.1042/BCJ20210285">10.1042/BCJ20210285</a>'
  apa: 'Sazanov, L. A. (2023). From the “black box” to “domino effect” mechanism:
    What have we learned from the structures of respiratory complex I. <i>The Biochemical
    Journal</i>. Portland Press. <a href="https://doi.org/10.1042/BCJ20210285">https://doi.org/10.1042/BCJ20210285</a>'
  chicago: 'Sazanov, Leonid A. “From the ‘black Box’ to ‘Domino Effect’ Mechanism:
    What Have We Learned from the Structures of Respiratory Complex I.” <i>The Biochemical
    Journal</i>. Portland Press, 2023. <a href="https://doi.org/10.1042/BCJ20210285">https://doi.org/10.1042/BCJ20210285</a>.'
  ieee: 'L. A. Sazanov, “From the ‘black box’ to ‘domino effect’ mechanism: What have
    we learned from the structures of respiratory complex I,” <i>The Biochemical Journal</i>,
    vol. 480, no. 5. Portland Press, pp. 319–333, 2023.'
  ista: 'Sazanov LA. 2023. From the ‘black box’ to ‘domino effect’ mechanism: What
    have we learned from the structures of respiratory complex I. The Biochemical
    Journal. 480(5), 319–333.'
  mla: 'Sazanov, Leonid A. “From the ‘black Box’ to ‘Domino Effect’ Mechanism: What
    Have We Learned from the Structures of Respiratory Complex I.” <i>The Biochemical
    Journal</i>, vol. 480, no. 5, Portland Press, 2023, pp. 319–33, doi:<a href="https://doi.org/10.1042/BCJ20210285">10.1042/BCJ20210285</a>.'
  short: L.A. Sazanov, The Biochemical Journal 480 (2023) 319–333.
corr_author: '1'
date_created: 2023-03-26T22:01:06Z
date_published: 2023-03-15T00:00:00Z
date_updated: 2024-10-09T21:04:50Z
day: '15'
ddc:
- '570'
department:
- _id: LeSa
doi: 10.1042/BCJ20210285
external_id:
  isi:
  - '000957065700001'
  pmid:
  - '36920092'
has_accepted_license: '1'
intvolume: '       480'
isi: 1
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1042/BCJ20210285
month: '03'
oa: 1
oa_version: Published Version
page: 319-333
pmid: 1
publication: The Biochemical Journal
publication_identifier:
  eissn:
  - 1470-8728
  issn:
  - 0264-6021
publication_status: published
publisher: Portland Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'From the ''black box'' to ''domino effect'' mechanism: What have we learned
  from the structures of respiratory complex I'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 480
year: '2023'
...
