---
OA_place: publisher
OA_type: hybrid
_id: '20325'
abstract:
- lang: eng
text: Inferring genealogical relationships of wild populations is useful because
it gives direct estimates of mating patterns and variance in reproductive success.
Inference can be improved by including information about parentage shared between
siblings, or by modelling phenotypes or population data related to mating. However,
we currently lack a framework to infer parent–offspring relationships, sibships
and population parameters in a single analysis. To address this, we here extend
a previous method, Fractional Analysis of Paternity and Sibships, to include population
data for the case where one parent is known. We illustrate this with the example
of pollen dispersal in a natural hybrid zone population of the snapdragon Antirrhinum
majus. Pollen dispersal is leptokurtic, with half of mating events occurring within
30 m, but with a long tail of mating events up to 859 m. Using simulations, we
find that both sibship and population information substantially improve pedigree
reconstruction, and that we can expect to resolve median dispersal distances with
high accuracy.
acknowledgement: 'We thank a large number of field volunteers for maintaining the
population sampling, and Tom White for assistance with seed collection. We thank
Sylvia Rebel for plating tissue for DNA extraction, as well as Sean Stankowski and
two anonymous reviewers for feedback on the manuscript. '
article_number: e70051
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Thomas
full_name: Ellis, Thomas
id: 3153D6D4-F248-11E8-B48F-1D18A9856A87
last_name: Ellis
orcid: 0000-0002-8511-0254
- first_name: David
full_name: Field, David
id: 419049E2-F248-11E8-B48F-1D18A9856A87
last_name: Field
orcid: 0000-0002-4014-8478
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Ellis T, Field D, Barton NH. Joint estimation of paternity, sibships and pollen
dispersal in a snapdragon hybrid zone. Molecular Ecology. 2025;34(15).
doi:10.1111/mec.70051
apa: Ellis, T., Field, D., & Barton, N. H. (2025). Joint estimation of paternity,
sibships and pollen dispersal in a snapdragon hybrid zone. Molecular Ecology.
Wiley. https://doi.org/10.1111/mec.70051
chicago: Ellis, Thomas, David Field, and Nicholas H Barton. “Joint Estimation of
Paternity, Sibships and Pollen Dispersal in a Snapdragon Hybrid Zone.” Molecular
Ecology. Wiley, 2025. https://doi.org/10.1111/mec.70051.
ieee: T. Ellis, D. Field, and N. H. Barton, “Joint estimation of paternity, sibships
and pollen dispersal in a snapdragon hybrid zone,” Molecular Ecology, vol.
34, no. 15. Wiley, 2025.
ista: Ellis T, Field D, Barton NH. 2025. Joint estimation of paternity, sibships
and pollen dispersal in a snapdragon hybrid zone. Molecular Ecology. 34(15), e70051.
mla: Ellis, Thomas, et al. “Joint Estimation of Paternity, Sibships and Pollen Dispersal
in a Snapdragon Hybrid Zone.” Molecular Ecology, vol. 34, no. 15, e70051,
Wiley, 2025, doi:10.1111/mec.70051.
short: T. Ellis, D. Field, N.H. Barton, Molecular Ecology 34 (2025).
corr_author: '1'
date_created: 2025-09-10T05:42:23Z
date_published: 2025-09-02T00:00:00Z
date_updated: 2025-12-30T10:12:34Z
day: '02'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1111/mec.70051
external_id:
isi:
- '001542913000001'
pmid:
- '40751392'
file:
- access_level: open_access
checksum: 5059ad4d74e6327b84b5282a39d36774
content_type: application/pdf
creator: dernst
date_created: 2025-12-30T10:12:17Z
date_updated: 2025-12-30T10:12:17Z
file_id: '20911'
file_name: 2025_MolecularEcology_Ellis.pdf
file_size: 1698605
relation: main_file
success: 1
file_date_updated: 2025-12-30T10:12:17Z
has_accepted_license: '1'
intvolume: ' 34'
isi: 1
issue: '15'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
publication: Molecular Ecology
publication_identifier:
eissn:
- 1365-294X
issn:
- 0962-1083
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Joint estimation of paternity, sibships and pollen dispersal in a snapdragon
hybrid zone
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20330'
abstract:
- lang: eng
text: The evolution of sexual dimorphism (the difference in average trait values
between females and males, SD), is often thought to be constrained by shared genetic
architecture between the sexes. Indeed, it is commonly expected that SD should
negatively correlate with the intersex correlation (the genetic correlation between
effects of segregating variants in females and males, r fm), either because (1)
traits with ancestrally low r fm are less constrained in their ability to respond
to sex-specific selection and thus evolve to be more dimorphic, or because (2)
sex-specific selection, driving sexual dimorphism evolution, also acts to reduce
r fm. Despite the intuitive appeal and prominence of these ideas, their generality
and the conditions in which they hold remain unclear. Here, we develop models
incorporating sex-specific stabilizing selection, mutation and genetic drift to
examine the relationship between r fm and SD. We show that the two commonly-discussed
mechanisms with the potential to generate a negative correlation between SD and
r fm could just as easily generate a positive association, since the standard
line of reasoning hinges on a hidden assumption that sex-specific adaptation more
frequently favors increased dimorphism than reduced dimorphism. Our results provide,
to our knowledge, the first mechanistic framework for understanding the conditions
under which a correlation between r fm and SD may arise and offer a compelling
explanation for inconsistent empirical evidence. We also make the intriguing observation
that—even when selection between the two sexes is identical—drift generates nonzero
SD. We quantify this effect and discuss its significance.
acknowledgement: We thank Tim Connallon for useful discussions and correspondence,
Himani Sachdeva and Nick Barton for comments on the manuscript and the Scientific
Computing unit at ISTA for technical support. GP is the recipient of a DOC Fellowship
of the Austrian Academy of Sciences at the Institute of Science and Technology Austria
(DOC 25817) and received funding from the European Union’s Horizon 2020 research
and innovation program under the Marie Skłodowska-Curie Grant (agreement no. 665385).
LH received funding from the European Research Council, under the HaplotypeStructure
Grant (grant no. 101055327) to Nick Barton.
article_number: iyaf175
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Gemma
full_name: Puixeu Sala, Gemma
id: 33AB266C-F248-11E8-B48F-1D18A9856A87
last_name: Puixeu Sala
orcid: 0000-0001-8330-1754
- first_name: Laura
full_name: Hayward, Laura
id: fc885ee5-24bf-11eb-ad7b-bcc5104c0c1b
last_name: Hayward
citation:
ama: 'Puixeu Sala G, Hayward L. The relationship between sexual dimorphism and intersex
correlation: Do models support intuition? Genetics. 2025;231(3). doi:10.1093/genetics/iyaf175'
apa: 'Puixeu Sala, G., & Hayward, L. (2025). The relationship between sexual
dimorphism and intersex correlation: Do models support intuition? Genetics.
Oxford University Press. https://doi.org/10.1093/genetics/iyaf175'
chicago: 'Puixeu Sala, Gemma, and Laura Hayward. “The Relationship between Sexual
Dimorphism and Intersex Correlation: Do Models Support Intuition?” Genetics.
Oxford University Press, 2025. https://doi.org/10.1093/genetics/iyaf175.'
ieee: 'G. Puixeu Sala and L. Hayward, “The relationship between sexual dimorphism
and intersex correlation: Do models support intuition?,” Genetics, vol.
231, no. 3. Oxford University Press, 2025.'
ista: 'Puixeu Sala G, Hayward L. 2025. The relationship between sexual dimorphism
and intersex correlation: Do models support intuition? Genetics. 231(3), iyaf175.'
mla: 'Puixeu Sala, Gemma, and Laura Hayward. “The Relationship between Sexual Dimorphism
and Intersex Correlation: Do Models Support Intuition?” Genetics, vol.
231, no. 3, iyaf175, Oxford University Press, 2025, doi:10.1093/genetics/iyaf175.'
short: G. Puixeu Sala, L. Hayward, Genetics 231 (2025).
corr_author: '1'
date_created: 2025-09-10T05:48:04Z
date_published: 2025-11-01T00:00:00Z
date_updated: 2026-01-05T13:04:07Z
day: '01'
ddc:
- '570'
department:
- _id: BeVi
- _id: NiBa
doi: 10.1093/genetics/iyaf175
ec_funded: 1
external_id:
isi:
- '001598595000001'
file:
- access_level: open_access
checksum: bbb73bbf8617812d4d8db4af92be9538
content_type: application/pdf
creator: dernst
date_created: 2026-01-05T13:03:18Z
date_updated: 2026-01-05T13:03:18Z
file_id: '20946'
file_name: 2025_Genetics_Puixeu.pdf
file_size: 1550562
relation: main_file
success: 1
file_date_updated: 2026-01-05T13:03:18Z
has_accepted_license: '1'
intvolume: ' 231'
isi: 1
issue: '3'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 9B9DFC9E-BA93-11EA-9121-9846C619BF3A
grant_number: '25817'
name: 'Sexual conflict: resolution, constraints and biomedical implications'
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: bd6958e0-d553-11ed-ba76-86eba6a76c00
grant_number: '101055327'
name: Understanding the evolution of continuous genomes
publication: Genetics
publication_identifier:
issn:
- 1943-2631
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The relationship between sexual dimorphism and intersex correlation: Do models
support intuition?'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 231
year: '2025'
...
---
OA_type: closed access
_id: '20429'
abstract:
- lang: eng
text: Plant–plant interactions are key to understanding ecosystem services and shaping
restoration strategies, as they can produce either negative or positive effects,
determining species establishment and growth. Recognizing these interactions during
early-life stages provides valuable insights for restoration in human-disturbed
areas. One promising approach is nucleation planting, which establishes small
clusters of native species in strategically selected sites, being particularly
useful in sites with large herbivores. In southern Patagonia, livestock production
has historically been the main economic activity, severely impacting extensive
areas of Nothofagus antarctica forest through grazing and intentional burning
to increase forage. In this context, nucleation planting with Berberis microphylla,
a non-palatable shrub, could foster forest recovery in degraded sites. To evaluate
this, we conducted an experiment testing the response of trees to varying shrub
number, while also assessing intraspecific effects in both species. We measured
survival, biomass, and functional traits. Results showed that the combination
of four shrubs surrounding a single tree maintained tree survival at levels comparable
to trees growing alone, while seedlings exhibited conspecific negative plant number
dependence. Additionally, B. microphylla increased its below- to above-ground
biomass ratio under higher plant number, indicating resource reallocation and
niche differentiation through spatial separation of root systems.
article_processing_charge: No
article_type: original
author:
- first_name: Gimena Noemí
full_name: Bustamante, Gimena Noemí
last_name: Bustamante
- first_name: Miriam Elisabet
full_name: Arena, Miriam Elisabet
last_name: Arena
- first_name: Luciano
full_name: Selzer, Luciano
last_name: Selzer
- first_name: Matthew
full_name: Ruggirello, Matthew
last_name: Ruggirello
- first_name: Paula
full_name: Rodríguez, Paula
last_name: Rodríguez
- first_name: Samuele
full_name: Pedrazzani, Samuele
last_name: Pedrazzani
- first_name: Jose Antonio
full_name: Navarro-Cano, Jose Antonio
last_name: Navarro-Cano
- first_name: Rosina Matilde
full_name: Soler Schaller, Rosina Matilde
id: 9e668447-8c32-11ed-b0c7-8dc2d7b80803
last_name: Soler Schaller
citation:
ama: 'Bustamante GN, Arena ME, Selzer L, et al. Biotic interactions between trees
and colonizing shrubs: Implications for active restoration in southern Patagonian
forests. Plant Ecology. 2025;226:1301-1313. doi:10.1007/s11258-025-01568-0'
apa: 'Bustamante, G. N., Arena, M. E., Selzer, L., Ruggirello, M., Rodríguez, P.,
Pedrazzani, S., … Soler Schaller, R. M. (2025). Biotic interactions between trees
and colonizing shrubs: Implications for active restoration in southern Patagonian
forests. Plant Ecology. Springer Nature. https://doi.org/10.1007/s11258-025-01568-0'
chicago: 'Bustamante, Gimena Noemí, Miriam Elisabet Arena, Luciano Selzer, Matthew
Ruggirello, Paula Rodríguez, Samuele Pedrazzani, Jose Antonio Navarro-Cano, and
Rosina Matilde Soler Schaller. “Biotic Interactions between Trees and Colonizing
Shrubs: Implications for Active Restoration in Southern Patagonian Forests.” Plant
Ecology. Springer Nature, 2025. https://doi.org/10.1007/s11258-025-01568-0.'
ieee: 'G. N. Bustamante et al., “Biotic interactions between trees and colonizing
shrubs: Implications for active restoration in southern Patagonian forests,” Plant
Ecology, vol. 226. Springer Nature, pp. 1301–1313, 2025.'
ista: 'Bustamante GN, Arena ME, Selzer L, Ruggirello M, Rodríguez P, Pedrazzani
S, Navarro-Cano JA, Soler Schaller RM. 2025. Biotic interactions between trees
and colonizing shrubs: Implications for active restoration in southern Patagonian
forests. Plant Ecology. 226, 1301–1313.'
mla: 'Bustamante, Gimena Noemí, et al. “Biotic Interactions between Trees and Colonizing
Shrubs: Implications for Active Restoration in Southern Patagonian Forests.” Plant
Ecology, vol. 226, Springer Nature, 2025, pp. 1301–13, doi:10.1007/s11258-025-01568-0.'
short: G.N. Bustamante, M.E. Arena, L. Selzer, M. Ruggirello, P. Rodríguez, S. Pedrazzani,
J.A. Navarro-Cano, R.M. Soler Schaller, Plant Ecology 226 (2025) 1301–1313.
date_created: 2025-10-05T22:01:36Z
date_published: 2025-12-01T00:00:00Z
date_updated: 2026-01-05T13:23:57Z
day: '01'
department:
- _id: NiBa
doi: 10.1007/s11258-025-01568-0
external_id:
isi:
- '001581599800001'
intvolume: ' 226'
isi: 1
language:
- iso: eng
month: '12'
oa_version: None
page: 1301-1313
publication: Plant Ecology
publication_identifier:
eissn:
- 1573-5052
issn:
- 1385-0237
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Biotic interactions between trees and colonizing shrubs: Implications for
active restoration in southern Patagonian forests'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 226
year: '2025'
...
---
OA_place: repository
OA_type: green
_id: '20531'
abstract:
- lang: eng
text: Genetic drift is potentially an important component of selection for sex,
as it is a source of statistical associations between alleles at selected loci.
By increasing local drift, population structure may thus amplify the evolutionary
advantage of sex. However, most previous models have focused either on haploid
populations or on diploid populations without spatial structure. In this article,
we use two- and three-locus analytical models and multilocus simulations to explore
selection for sex in a diploid population structured according to the island model,
in the presence of recurrent deleterious mutations. Our results show that selection
generally favors an intermediate rate of sex that decreases as the direct cost
of sex increases and increases moderately as the degree of population structure
increases. Selection for sex is generated by multiple effects involving genetic
associations within and between loci. When selection occurs at many loci, it is
generally dominated by interference effects involving deleterious alleles at different
loci, captured by our three-locus model. In our multilocus simulations, we observed
an irreversible spread of asexual mutants under strong costs of sex, and when
deleterious mutations are partially recessive. However, population structure may
prevent this spread of asexual mutants when dispersal rates are sufficiently small.
acknowledgement: L.F. is funded by the NOMIS-ISTA Fellowship Program. We thank Colin
Olito and two anonymous reviewers for helpful comments, and the bioinformatics and
computing services at Roscoff’s Biological Station (Abims platform) and at Institute
of Science and Technology Austria for computing time.
article_processing_charge: No
article_type: original
author:
- first_name: Louise
full_name: Fouqueau, Louise
id: 1676e173-8143-11ed-8927-fe165216a93f
last_name: Fouqueau
orcid: 0000-0003-0371-9339
- first_name: Denis
full_name: Roze, Denis
last_name: Roze
citation:
ama: Fouqueau L, Roze D. Deleterious mutations and selection for sex in spatially
structured, diploid populations. Evolution. 2025;79(10):2167-2180. doi:10.1093/evolut/qpaf143
apa: Fouqueau, L., & Roze, D. (2025). Deleterious mutations and selection for
sex in spatially structured, diploid populations. Evolution. Oxford University
Press. https://doi.org/10.1093/evolut/qpaf143
chicago: Fouqueau, Louise, and Denis Roze. “Deleterious Mutations and Selection
for Sex in Spatially Structured, Diploid Populations.” Evolution. Oxford
University Press, 2025. https://doi.org/10.1093/evolut/qpaf143.
ieee: L. Fouqueau and D. Roze, “Deleterious mutations and selection for sex in spatially
structured, diploid populations,” Evolution, vol. 79, no. 10. Oxford University
Press, pp. 2167–2180, 2025.
ista: Fouqueau L, Roze D. 2025. Deleterious mutations and selection for sex in spatially
structured, diploid populations. Evolution. 79(10), 2167–2180.
mla: Fouqueau, Louise, and Denis Roze. “Deleterious Mutations and Selection for
Sex in Spatially Structured, Diploid Populations.” Evolution, vol. 79,
no. 10, Oxford University Press, 2025, pp. 2167–80, doi:10.1093/evolut/qpaf143.
short: L. Fouqueau, D. Roze, Evolution 79 (2025) 2167–2180.
date_created: 2025-10-26T23:01:34Z
date_published: 2025-10-17T00:00:00Z
date_updated: 2025-12-01T15:03:54Z
day: '17'
department:
- _id: NiBa
doi: 10.1093/evolut/qpaf143
external_id:
isi:
- '001547542300001'
pmid:
- '40668071'
intvolume: ' 79'
isi: 1
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2025.01.22.634382
month: '10'
oa: 1
oa_version: Preprint
page: 2167-2180
pmid: 1
project:
- _id: 9B861AAC-BA93-11EA-9121-9846C619BF3A
name: NOMIS Fellowship Program
publication: Evolution
publication_identifier:
eissn:
- 1558-5646
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Deleterious mutations and selection for sex in spatially structured, diploid
populations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 79
year: '2025'
...
---
OA_place: publisher
_id: '20694'
abstract:
- lang: eng
text: "Understanding the mechanisms underlying speciation is a central aim of evolutionary
biology.\r\nA persistent challenge in the field is to identify loci that contribute
to reproductive isolation,\r\nwhile disentangling signals of selection from demography,
linkage and intrinsic genomic\r\nfeatures. Traditional population genomic approaches
that rely on site-based statistics in\r\narbitrary fixed windows face inherent
limitations, as they conflate historical and\r\ncontemporary processes of divergence
and overlook haplotype structure. Recent advances in\r\nwhole-genome sequencing
and methods to infer ancestral recombination graphs (ARGs) now\r\noffer the opportunity
to study genealogical relationships explicitly, revealing how lineages\r\ncoalesce
and recombine through time. By directly analysing haplotype clustering by species\r\nor
phenotype and their patterns of coalescence, ARG-based methods show promise for\r\ndiagnosing
sweeps, identifying barrier loci maintained under divergent selection amid gene\r\nflow,
and tracing their evolutionary history.\r\nIn this thesis, I explore the utility
of genealogical approaches for studying species\r\ndivergence. In chapter 2, I
propose a conceptual framework for defining haplotype blocks\r\nthrough the structure
of the ARG, using simulations and empirical data to highlight how\r\ngenealogical
processes generate rich and often overlooked haplotypic patterns.\r\nIn chapter
3, I examine the genomic basis of a key evolutionary innovation in marine\r\nsnails
Littorina. These snails offer a unique opportunity to study an innovation because
they\r\ninclude a very recent transition from egg-laying to live bearing, yet
snails with the different\r\nreproductive modes are not reciprocally monophyletic.
I exploited this by using topology\r\nclustering in ARG-derived local genealogical
trees to pinpoint narrow genomic regions or\r\nhaplotype blocks that carry swept
alleles, thus revealing that the transition from egg-laying\r\nto live-bearing
involves multiple, live-bearer-specific sweeps.\r\nChapter 4 establishes a population-scale,
phased genomic resource for Antirrhinum\r\nmajus, using cost-effective haplotagging,
then optimizes imputation from low-coverage data\r\nagainst high-accuracy KASP
sequencing to maximize sequence completeness with modest\r\naccuracy trade-offs
against a traditional short-read sequence pipeline. A hybrid phasing\r\nstrategy
combines molecular phasing with statistical phasing to generate phased whole\r\ngenome
sequences of 1084 Antirrhinum individuals at a fraction of long-read sequencing\r\ncosts.\r\nIn
chapter 5, I analyse hybridising populations from two replicate hybrid zones to
find\r\na parallel genetic basis of flower colour, amidst the noise in genomic
differentiation landscape\r\ndriven by variation in demographic history. While
outlier genome scans of FST failed to dissect\r\nthe causes of differentiation,
ARG-based topology clustering revealed a reuse of colour\r\nassociated haplotypes
across hybrid zones. In addition to the biological insight, this chapter\r\nalso
presents a comparison of the latest ARG inference tools, showing that signals
of\r\nAbstract\r\nviii\r\ntopological clustering qualitatively agree between methods,
despite differences in the tree\r\nsequences.\r\nNext, in chapter 6, by leveraging
~1000 individuals in one of the hybrid zones, I\r\nintegrated genome-wide association
studies of floral pigmentation with genealogical\r\ninference, to test for additional
colour loci, and confirm the effect of previously described loci.\r\nThis work
demonstrates that flower colour variation is driven by a small number of large
effect\r\nloci, while also hinting at the presence of a new candidate regulatory
factor.\r\nFinally in chapter 7, in a preliminary analysis, I begin to dissect
the genomic island of\r\nspeciation around Rosea/Eluta to understand its evolutionary
origins. My results show that it\r\nconsists of 5 highly divergent loci, each
of which is associated with flower colour. Using\r\npatterns of coalescence in
genealogical trees, I find evidence of staggered selective sweeps\r\nand a persistent
localized barrier to gene flow within an otherwise permeable genome.\r\nTogether,
these chapters add to the increasing pool of studies using genealogical\r\napproaches
to complement and extend site-based statistics to use haplotype structures in\r\nspeciation
research. By tracking haplotypes directly and connecting genealogical clustering
to\r\npopulation processes, ARG-based inference promises to provide new insights
into how local\r\nselective pressures, demographic history, and long-term barriers
interact to shape the\r\ngenomic architecture of divergence. By underscoring the
value of ARGs in revealing the finescale origins and maintenance of biodiversity,
this thesis presents cautious optimism about\r\nthe benefits of using genealogical
inference to learn more than what site-based statistics\r\ncould tell us."
acknowledged_ssus:
- _id: ScienComp
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Arka
full_name: Pal, Arka
id: 6AAB2240-CA9A-11E9-9C1A-D9D1E5697425
last_name: Pal
orcid: 0000-0002-4530-8469
citation:
ama: Pal A. Using genealogies to study the genomic basis of species divergence.
2025. doi:10.15479/AT-ISTA-20694
apa: Pal, A. (2025). Using genealogies to study the genomic basis of species
divergence. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20694
chicago: Pal, Arka. “Using Genealogies to Study the Genomic Basis of Species Divergence.”
Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20694.
ieee: A. Pal, “Using genealogies to study the genomic basis of species divergence,”
Institute of Science and Technology Austria, 2025.
ista: Pal A. 2025. Using genealogies to study the genomic basis of species divergence.
Institute of Science and Technology Austria.
mla: Pal, Arka. Using Genealogies to Study the Genomic Basis of Species Divergence.
Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20694.
short: A. Pal, Using Genealogies to Study the Genomic Basis of Species Divergence,
Institute of Science and Technology Austria, 2025.
corr_author: '1'
date_created: 2025-11-25T13:19:11Z
date_published: 2025-11-25T00:00:00Z
date_updated: 2026-04-28T13:20:36Z
day: '25'
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degree_awarded: PhD
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doi: 10.15479/AT-ISTA-20694
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page: '268'
project:
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grant_number: '101055327'
name: Understanding the evolution of continuous genomes
- _id: 05959E1C-7A3F-11EA-A408-12923DDC885E
grant_number: P32166
name: Snapdragon Speciation
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
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status: public
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relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
title: Using genealogies to study the genomic basis of species divergence
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...
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_id: '20190'
abstract:
- lang: eng
text: 'A major goal of speciation research is identifying loci that underpin barriers
to gene flow. Population genomics takes a ‘bottom-up’ approach, scanning the genome
for molecular signatures of processes that drive or maintain divergence. However,
interpreting the ‘genomic landscape’ of speciation is complicated, because genome
scans conflate multiple processes, most of which are not informative about gene
flow. However, studying replicated population contrasts, including multiple incidences
of secondary contact, can strengthen inferences. In this paper, we use linked-read
sequencing (haplotagging), FST scans and genealogical methods to characterise
the genomic landscape associated with replicate hybrid zone formation. We studied
two flower colour varieties of the common snapdragon, Antirrhinum majus subspecies
majus, that form secondary hybrid zones in multiple independent valleys in the
Pyrenees. Consistent with past work, we found very low differentiation at one
well-studied zone (Planoles). However, at a second zone (Avellanet), we found
stronger differentiation and greater heterogeneity, which we argue is due to differences
in the amount of introgression following secondary contact. Topology weighting
of genealogical trees identified loci where haplotype diversity was associated
with the two snapdragon varieties. Two of the strongest associations were at previously
identified flower colour loci: Flavia, that affects yellow pigmentation, and Rosea/Eluta,
two linked loci that affect magenta pigmentation. Preliminary analysis of coalescence
times provides additional evidence for selective sweeps at these loci and barriers
to gene flow. Our study highlights the impact of demographic history on the differentiation
landscape, emphasising the need to distinguish between historical divergence and
recent introgression.'
acknowledged_ssus:
- _id: ScienComp
acknowledgement: 'We thank ESEB Godfrey Hewitt Mobility Award for supporting AP’s
research stay at UC Davis. We thank Tom Ellis, Parvathy Surendranadh, and other
Barton Group and Coop Lab members for stimulating discussions. We are grateful to
all the interns and volunteers who have helped us with fieldwork. We thank Eva Salmerón
Mateu for her assistance in fieldwork logistics at the field station, El Serrat.
We are grateful to Enrico Coen and his research group for providing the Antirrhinum
molle PoolSeq data used in the allele polarisation. We are also thankful to Enrico
Coen and Cristophe Thébaud for discovering the Avellanet hybrid zone, followed up
with sampling led by D.L.F. in 2017. The study was supported by Austrian Science
Fund (FWF) Grant (Snapdragon Speciation P32166, awarded to D.L.F.); ERC (Advanced
Grant HaplotypeStructure 101055327, awarded to NHB); ERC (POC Grant 101069216, awarded
to Y.F.C.) and the National Institutes of Health (NIH R35 GM136290, awarded to G.C.).
Y.F.C. was supported by the Max Planck Society. Computing infrastructure for bioinformatics
and analyses was provided by ISTA High Performance Cluster. '
article_number: e70067
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Arka
full_name: Pal, Arka
id: 6AAB2240-CA9A-11E9-9C1A-D9D1E5697425
last_name: Pal
orcid: 0000-0002-4530-8469
- first_name: Daria
full_name: Shipilina, Daria
id: 428A94B0-F248-11E8-B48F-1D18A9856A87
last_name: Shipilina
orcid: 0000-0002-1145-9226
- first_name: Alan
full_name: Le Moan, Alan
last_name: Le Moan
- first_name: Adrian J.
full_name: Mcnairn, Adrian J.
last_name: Mcnairn
- first_name: Jennifer K.
full_name: Grenier, Jennifer K.
last_name: Grenier
- first_name: Marek
full_name: Kucka, Marek
last_name: Kucka
- first_name: Graham
full_name: Coop, Graham
last_name: Coop
- first_name: Yingguang Frank
full_name: Chan, Yingguang Frank
last_name: Chan
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: David
full_name: Field, David
id: 419049E2-F248-11E8-B48F-1D18A9856A87
last_name: Field
orcid: 0000-0002-4014-8478
- first_name: Sean
full_name: Stankowski, Sean
id: 43161670-5719-11EA-8025-FABC3DDC885E
last_name: Stankowski
citation:
ama: Pal A, Shipilina D, Le Moan A, et al. Genealogical analysis of replicate flower
colour hybrid zones in Antirrhinum. Molecular Ecology. 2025;34(22). doi:10.1111/mec.70067
apa: Pal, A., Shipilina, D., Le Moan, A., Mcnairn, A. J., Grenier, J. K., Kucka,
M., … Stankowski, S. (2025). Genealogical analysis of replicate flower colour
hybrid zones in Antirrhinum. Molecular Ecology. Wiley. https://doi.org/10.1111/mec.70067
chicago: Pal, Arka, Daria Shipilina, Alan Le Moan, Adrian J. Mcnairn, Jennifer K.
Grenier, Marek Kucka, Graham Coop, et al. “Genealogical Analysis of Replicate
Flower Colour Hybrid Zones in Antirrhinum.” Molecular Ecology. Wiley, 2025.
https://doi.org/10.1111/mec.70067.
ieee: A. Pal et al., “Genealogical analysis of replicate flower colour hybrid
zones in Antirrhinum,” Molecular Ecology, vol. 34, no. 22. Wiley, 2025.
ista: Pal A, Shipilina D, Le Moan A, Mcnairn AJ, Grenier JK, Kucka M, Coop G, Chan
YF, Barton NH, Field D, Stankowski S. 2025. Genealogical analysis of replicate
flower colour hybrid zones in Antirrhinum. Molecular Ecology. 34(22), e70067.
mla: Pal, Arka, et al. “Genealogical Analysis of Replicate Flower Colour Hybrid
Zones in Antirrhinum.” Molecular Ecology, vol. 34, no. 22, e70067, Wiley,
2025, doi:10.1111/mec.70067.
short: A. Pal, D. Shipilina, A. Le Moan, A.J. Mcnairn, J.K. Grenier, M. Kucka, G.
Coop, Y.F. Chan, N.H. Barton, D. Field, S. Stankowski, Molecular Ecology 34 (2025).
corr_author: '1'
date_created: 2025-08-17T22:01:37Z
date_published: 2025-11-01T00:00:00Z
date_updated: 2026-08-25T22:30:41Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1111/mec.70067
external_id:
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- '001546622100001'
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checksum: c586fc674df4e7dd6e43aef87a52c6f6
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creator: dernst
date_created: 2026-01-05T13:47:47Z
date_updated: 2026-01-05T13:47:47Z
file_id: '20958'
file_name: 2025_MolecEcology_Pal.pdf
file_size: 9886694
relation: main_file
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file_date_updated: 2026-01-05T13:47:47Z
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intvolume: ' 34'
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language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 05959E1C-7A3F-11EA-A408-12923DDC885E
grant_number: P32166
name: Snapdragon Speciation
- _id: bd6958e0-d553-11ed-ba76-86eba6a76c00
grant_number: '101055327'
name: Understanding the evolution of continuous genomes
publication: Molecular Ecology
publication_identifier:
eissn:
- 1365-294X
issn:
- 0962-1083
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/snapdragon-secrets/
record:
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relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Genealogical analysis of replicate flower colour hybrid zones in Antirrhinum
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 34
year: '2025'
...
---
OA_type: green
_id: '21967'
abstract:
- lang: eng
text: "Selection against deleterious mutations, called purifying selection, plays
a central role in evolution and acts in all populations. It is known that the
genetic patterns observed in genomic regions undergoing purifying selection differ
from those resulting from neutral evolution. However, a comprehensive understanding
of the underlying mechanisms shaping those patterns is still lacking.\r\n\r\nIn
the present work, we use simulations combined with a genealogical approach to
identify the effect of purifying selection on the ancestry and thus on the genetic
diversity. Our analysis relies on the postulate that the genealogy belongs to
the universality class of Beta-coalescents. Under this assumption, we derive statistics
measuring the distortion of the genealogy. This approach allows us to consider
a wide range of regimes (i.e. arbitrary selection and mutation strengths) and
uncover a rich phase diagram. We find that, for strong selection, the limiting
genealogy is given by Kingman’s coalescent on a polynomial timescale. As selection
gets weaker, Muller’s ratchet starts operating, setting off the emergence of multiple
mergers in the genealogical structures. Our results show that while multiple-merger
coalescents are often interpreted as the signature of selective sweeps in rapidly
adapting populations, these structures can also appear in the context of Muller’s
ratchet."
acknowledgement: This work was supported by the Austrian Academy of Science, DOC fellowship
No 26293 (K.K.) and the European Union’s Horizon 2020 research and innovation programme
under the Marie Skłodowska-Curie grant agreement No 101034413 (J.T.). Simulations
were performed on the ISTA High-performance Computing Cluster.
article_processing_charge: No
author:
- first_name: Kseniia
full_name: Khudiakova, Kseniia
id: 4E6DC800-AE37-11E9-AC72-31CAE5697425
last_name: Khudiakova
orcid: 0000-0002-6246-1465
- first_name: Florin
full_name: Boenkost, Florin
last_name: Boenkost
- first_name: Julie N
full_name: Tourniaire, Julie N
id: 5dc06dd8-8e51-11ec-9170-8d9c450cc216
last_name: Tourniaire
citation:
ama: Khudiakova K, Boenkost F, Tourniaire JN. Genealogies under purifying selection.
bioRxiv. doi:10.1101/2024.10.15.618444
apa: Khudiakova, K., Boenkost, F., & Tourniaire, J. N. (n.d.). Genealogies under
purifying selection. bioRxiv. https://doi.org/10.1101/2024.10.15.618444
chicago: Khudiakova, Kseniia, Florin Boenkost, and Julie N Tourniaire. “Genealogies
under Purifying Selection.” BioRxiv, n.d. https://doi.org/10.1101/2024.10.15.618444.
ieee: K. Khudiakova, F. Boenkost, and J. N. Tourniaire, “Genealogies under purifying
selection,” bioRxiv. .
ista: Khudiakova K, Boenkost F, Tourniaire JN. Genealogies under purifying selection.
bioRxiv, 10.1101/2024.10.15.618444.
mla: Khudiakova, Kseniia, et al. “Genealogies under Purifying Selection.” BioRxiv,
doi:10.1101/2024.10.15.618444.
short: K. Khudiakova, F. Boenkost, J.N. Tourniaire, BioRxiv (n.d.).
corr_author: '1'
date_created: 2026-06-09T12:14:08Z
date_published: 2024-10-18T00:00:00Z
date_updated: 2026-06-12T12:43:34Z
day: '18'
department:
- _id: NiBa
- _id: JaMa
doi: 10.1101/2024.10.15.618444
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2024.10.15.618444
month: '10'
oa: 1
oa_version: Preprint
project:
- _id: 34d33d68-11ca-11ed-8bc3-ec13763c0ca8
grant_number: '26293'
name: The impact of deleterious mutations on small populations
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: bioRxiv
publication_status: draft
related_material:
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relation: dissertation_contains
status: public
status: public
title: Genealogies under purifying selection
tmp:
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legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
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(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: preprint
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2024'
...
---
OA_place: publisher
OA_type: hybrid
_id: '14463'
abstract:
- lang: eng
text: Inversions are thought to play a key role in adaptation and speciation, suppressing
recombination between diverging populations. Genes influencing adaptive traits
cluster in inversions, and changes in inversion frequencies are associated with
environmental differences. However, in many organisms, it is unclear if inversions
are geographically and taxonomically widespread. The intertidal snail, Littorina
saxatilis, is one such example. Strong associations between putative polymorphic
inversions and phenotypic differences have been demonstrated between two ecotypes
of L. saxatilis in Sweden and inferred elsewhere, but no direct evidence for inversion
polymorphism currently exists across the species range. Using whole genome data
from 107 snails, most inversion polymorphisms were found to be widespread across
the species range. The frequencies of some inversion arrangements were significantly
different among ecotypes, suggesting a parallel adaptive role. Many inversions
were also polymorphic in the sister species, L. arcana, hinting at an ancient
origin.
acknowledgement: We would like to thank members of the Littorina team for their advice
and feedback during this project. In particular, we thank Alan Le Moan, who inspired
us to look at heterozygosity differences to identify inversions, and Katherine Hearn
for helping with the PCA scripts. We thank Edinburgh Genomics for library preparation
and sequencing. Sample collections, sequencing and data preparation were supported
by the European Research Council (ERC-2015-AdG-693030- BARRIERS) and the Natural
Environment Research Council (NE/P001610/1). The analysis was supported by the Swedish
Research Council (vetenskaprådet; 2018-03695_VR) and the Portuguese Foundation for
Science and Technology (Fundación para a Ciência e Tecnologia) through a research
project (PTDC/BIA-EVL/1614/2021) and CEEC contract (2020.00275.CEECIND).
article_number: e17160
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: James
full_name: Reeve, James
last_name: Reeve
- first_name: Roger K.
full_name: Butlin, Roger K.
last_name: Butlin
- first_name: Eva L.
full_name: Koch, Eva L.
last_name: Koch
- first_name: Sean
full_name: Stankowski, Sean
id: 43161670-5719-11EA-8025-FABC3DDC885E
last_name: Stankowski
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
citation:
ama: Reeve J, Butlin RK, Koch EL, Stankowski S, Faria R. Chromosomal inversion polymorphisms
are widespread across the species ranges of rough periwinkles (Littorina saxatilis
and L. arcana). Molecular Ecology. 2024;33(24). doi:10.1111/mec.17160
apa: Reeve, J., Butlin, R. K., Koch, E. L., Stankowski, S., & Faria, R. (2024).
Chromosomal inversion polymorphisms are widespread across the species ranges of
rough periwinkles (Littorina saxatilis and L. arcana). Molecular Ecology.
Wiley. https://doi.org/10.1111/mec.17160
chicago: Reeve, James, Roger K. Butlin, Eva L. Koch, Sean Stankowski, and Rui Faria.
“Chromosomal Inversion Polymorphisms Are Widespread across the Species Ranges
of Rough Periwinkles (Littorina Saxatilis and L. Arcana).” Molecular Ecology.
Wiley, 2024. https://doi.org/10.1111/mec.17160.
ieee: J. Reeve, R. K. Butlin, E. L. Koch, S. Stankowski, and R. Faria, “Chromosomal
inversion polymorphisms are widespread across the species ranges of rough periwinkles
(Littorina saxatilis and L. arcana),” Molecular Ecology, vol. 33, no. 24.
Wiley, 2024.
ista: Reeve J, Butlin RK, Koch EL, Stankowski S, Faria R. 2024. Chromosomal inversion
polymorphisms are widespread across the species ranges of rough periwinkles (Littorina
saxatilis and L. arcana). Molecular Ecology. 33(24), e17160.
mla: Reeve, James, et al. “Chromosomal Inversion Polymorphisms Are Widespread across
the Species Ranges of Rough Periwinkles (Littorina Saxatilis and L. Arcana).”
Molecular Ecology, vol. 33, no. 24, e17160, Wiley, 2024, doi:10.1111/mec.17160.
short: J. Reeve, R.K. Butlin, E.L. Koch, S. Stankowski, R. Faria, Molecular Ecology
33 (2024).
date_created: 2023-10-29T23:01:17Z
date_published: 2024-12-01T00:00:00Z
date_updated: 2025-01-09T07:53:18Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1111/mec.17160
external_id:
isi:
- '001085119000001'
pmid:
- '37843465'
file:
- access_level: open_access
checksum: 686576036663f489c2d079df3079d126
content_type: application/pdf
creator: dernst
date_created: 2025-01-09T07:52:12Z
date_updated: 2025-01-09T07:52:12Z
file_id: '18785'
file_name: 2024_MolecularEcology_Reeve.pdf
file_size: 6228700
relation: main_file
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file_date_updated: 2025-01-09T07:52:12Z
has_accepted_license: '1'
intvolume: ' 33'
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language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
publication: Molecular Ecology
publication_identifier:
eissn:
- 1365-294X
issn:
- 0962-1083
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Chromosomal inversion polymorphisms are widespread across the species ranges
of rough periwinkles (Littorina saxatilis and L. arcana)
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2024'
...
---
OA_place: publisher
_id: '14711'
abstract:
- lang: eng
text: "In nature, different species find their niche in a range of environments,
each with its unique characteristics. While some thrive in uniform (homogeneous)
landscapes where environmental conditions stay relatively consistent across space,
others traverse the complexities of spatially heterogeneous terrains. Comprehending
how species are distributed and how they interact within these landscapes holds
the key to gaining insights into their evolutionary dynamics while also informing
conservation and management strategies.\r\n\r\nFor species inhabiting heterogeneous
landscapes, when the rate of dispersal is low compared to spatial fluctuations
in selection pressure, localized adaptations may emerge. Such adaptation in response
to varying selection strengths plays an important role in the persistence of populations
in our rapidly changing world. Hence, species in nature are continuously in a
struggle to adapt to local environmental conditions, to ensure their continued
survival. Natural populations can often adapt in time scales short enough for
evolutionary changes to influence ecological dynamics and vice versa, thereby
creating a feedback between evolution and demography. The analysis of this feedback
and the relative contributions of gene flow, demography, drift, and natural selection
to genetic variation and differentiation has remained a recurring theme in evolutionary
biology. Nevertheless, the effective role of these forces in maintaining variation
and shaping patterns of diversity is not fully understood. Even in homogeneous
environments devoid of local adaptations, such understanding remains elusive.
Understanding this feedback is crucial, for example in determining the conditions
under which extinction risk can be mitigated in peripheral populations subject
to deleterious mutation accumulation at the edges of species’ ranges\r\nas well
as in highly fragmented populations.\r\n\r\nIn this thesis we explore both uniform
and spatially heterogeneous metapopulations, investigating and providing theoretical
insights into the dynamics of local adaptation in the latter and examining the
dynamics of load and extinction as well as the impact of joint ecological and
evolutionary (eco-evolutionary) dynamics in the former. The thesis is divided
into 5 chapters.\r\n\r\nChapter 1 provides a general introduction into the subject
matter, clarifying concepts and ideas used throughout the thesis. In chapter 2,
we explore how fast a species distributed across a heterogeneous landscape adapts
to changing conditions marked by alterations in carrying capacity, selection pressure,
and migration rate.\r\n\r\nIn chapter 3, we investigate how migration selection
and drift influences adaptation and the maintenance of variation in a metapopulation
with three habitats, an extension of previous models of adaptation in two habitats.
We further develop analytical approximations for the critical threshold required
for polymorphism to persist.\r\n\r\nThe focus of chapter 4 of the thesis is on
understanding the interplay between ecology and evolution as coupled processes.
We investigate how eco-evolutionary feedback between migration, selection, drift,
and demography influences eco-evolutionary outcomes in marginal populations subject
to deleterious mutation accumulation. Using simulations as well as theoretical
approximations of the coupled dynamics of population size and allele frequency,
we analyze how gene flow from a large mainland source influences genetic load
and population size on an island (i.e., in a marginal population) under genetically
realistic assumptions. Analyses of this sort are important because small isolated
populations, are repeatedly affected by complex interactions between ecological
and evolutionary processes, which can lead to their death. Understanding these
interactions can therefore provide an insight into the conditions under which
extinction risk can be mitigated in peripheral populations thus, contributing
to conservation and restoration efforts.\r\n\r\nChapter 5 extends the analysis
in chapter 4 to consider the dynamics of load (due to deleterious mutation accumulation)
and extinction risk in a metapopulation. We explore the role of gene flow, selection,
and dominance on load and extinction risk and further pinpoint critical thresholds
required for metapopulation persistence.\r\n\r\nOverall this research contributes
to our understanding of ecological and evolutionary mechanisms that shape species’
persistence in fragmented landscapes, a crucial foundation for successful conservation
efforts and biodiversity management."
acknowledged_ssus:
- _id: SSU
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Oluwafunmilola O
full_name: Olusanya, Oluwafunmilola O
id: 41AD96DC-F248-11E8-B48F-1D18A9856A87
last_name: Olusanya
orcid: 0000-0003-1971-8314
citation:
ama: Olusanya OO. Local adaptation, genetic load and extinction in metapopulations.
2024. doi:10.15479/at:ista:14711
apa: Olusanya, O. O. (2024). Local adaptation, genetic load and extinction in
metapopulations. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14711
chicago: Olusanya, Oluwafunmilola O. “Local Adaptation, Genetic Load and Extinction
in Metapopulations.” Institute of Science and Technology Austria, 2024. https://doi.org/10.15479/at:ista:14711.
ieee: O. O. Olusanya, “Local adaptation, genetic load and extinction in metapopulations,”
Institute of Science and Technology Austria, 2024.
ista: Olusanya OO. 2024. Local adaptation, genetic load and extinction in metapopulations.
Institute of Science and Technology Austria.
mla: Olusanya, Oluwafunmilola O. Local Adaptation, Genetic Load and Extinction
in Metapopulations. Institute of Science and Technology Austria, 2024, doi:10.15479/at:ista:14711.
short: O.O. Olusanya, Local Adaptation, Genetic Load and Extinction in Metapopulations,
Institute of Science and Technology Austria, 2024.
corr_author: '1'
date_created: 2023-12-26T22:49:53Z
date_published: 2024-01-19T00:00:00Z
date_updated: 2026-04-07T12:54:29Z
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page: '183'
project:
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call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: c08d3278-5a5b-11eb-8a69-fdb09b55f4b8
grant_number: P32896
name: Causes and consequences of population fragmentation
- _id: 34c872fe-11ca-11ed-8bc3-8534b82131e6
grant_number: '26380'
name: Polygenic Adaptation in a Metapopulation
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
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relation: part_of_dissertation
status: public
- id: '10658'
relation: part_of_dissertation
status: public
- id: '14732'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Jitka
full_name: Polechova, Jitka
last_name: Polechova
- first_name: Himani
full_name: Sachdeva, Himani
last_name: Sachdeva
title: Local adaptation, genetic load and extinction in metapopulations
tmp:
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legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2024'
...
---
_id: '14850'
abstract:
- lang: eng
text: Elaborate sexual signals are thought to have evolved and be maintained to
serve as honest indicators of signaller quality. One measure of quality is health,
which can be affected by parasite infection. Cnemaspis mysoriensis is a diurnal
gecko that is often infested with ectoparasites in the wild, and males of this
species express visual (coloured gular patches) and chemical (femoral gland secretions)
traits that receivers could assess during social interactions. In this paper,
we tested whether ectoparasites affect individual health, and whether signal quality
is an indicator of ectoparasite levels. In wild lizards, we found that ectoparasite
level was negatively correlated with body condition in both sexes. Moreover, some
characteristics of both visual and chemical traits in males were strongly associated
with ectoparasite levels. Specifically, males with higher ectoparasite levels
had yellow gular patches with lower brightness and chroma, and chemical secretions
with a lower proportion of aromatic compounds. We then determined whether ectoparasite
levels in males influence female behaviour. Using sequential choice trials, wherein
females were provided with either the visual or the chemical signals of wild-caught
males that varied in ectoparasite level, we found that only chemical secretions
evoked an elevated female response towards less parasitised males. Simultaneous
choice trials in which females were exposed to the chemical secretions from males
that varied in parasite level further confirmed a preference for males with lower
parasites loads. Overall, we find that although health (body condition) or ectoparasite
load can be honestly advertised through multiple modalities, the parasite-mediated
female response is exclusively driven by chemical signals.
acknowledgement: "We thank Anuradha Batabyal and Shakilur Kabir for scientific discussions,
and help with sampling and colour analyses. We thank Muralidhar and the central
LCMS facility of the IISc for their technical support with the GCMS.\r\nResearch
funding was provided by the Department of Science and Technology Fund for Improvement
of S&T Infrastructure (DST-FIST), the Department of Biotechnology-Indian Institute
of Science (DBT-IISc) partnership program and a Science and Engineering Research
Board (SERB) grant to M.T. (EMR/2017/002228). Open Access funding provided by Indian
Institute of Science. Deposited in PMC for immediate release."
article_number: jeb246217
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Arka
full_name: Pal, Arka
id: 6AAB2240-CA9A-11E9-9C1A-D9D1E5697425
last_name: Pal
orcid: 0000-0002-4530-8469
- first_name: Mihir
full_name: Joshi, Mihir
last_name: Joshi
- first_name: Maria
full_name: Thaker, Maria
last_name: Thaker
citation:
ama: Pal A, Joshi M, Thaker M. Too much information? Males convey parasite levels
using more signal modalities than females utilise. Journal of Experimental
Biology. 2024;227(1). doi:10.1242/jeb.246217
apa: Pal, A., Joshi, M., & Thaker, M. (2024). Too much information? Males convey
parasite levels using more signal modalities than females utilise. Journal
of Experimental Biology. The Company of Biologists. https://doi.org/10.1242/jeb.246217
chicago: Pal, Arka, Mihir Joshi, and Maria Thaker. “Too Much Information? Males
Convey Parasite Levels Using More Signal Modalities than Females Utilise.” Journal
of Experimental Biology. The Company of Biologists, 2024. https://doi.org/10.1242/jeb.246217.
ieee: A. Pal, M. Joshi, and M. Thaker, “Too much information? Males convey parasite
levels using more signal modalities than females utilise,” Journal of Experimental
Biology, vol. 227, no. 1. The Company of Biologists, 2024.
ista: Pal A, Joshi M, Thaker M. 2024. Too much information? Males convey parasite
levels using more signal modalities than females utilise. Journal of Experimental
Biology. 227(1), jeb246217.
mla: Pal, Arka, et al. “Too Much Information? Males Convey Parasite Levels Using
More Signal Modalities than Females Utilise.” Journal of Experimental Biology,
vol. 227, no. 1, jeb246217, The Company of Biologists, 2024, doi:10.1242/jeb.246217.
short: A. Pal, M. Joshi, M. Thaker, Journal of Experimental Biology 227 (2024).
corr_author: '1'
date_created: 2024-01-22T08:14:49Z
date_published: 2024-01-10T00:00:00Z
date_updated: 2025-09-04T11:50:21Z
day: '10'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1242/jeb.246217
external_id:
isi:
- '001214515700016'
pmid:
- '38054353'
file:
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checksum: 136325372f6f45abaa62a71e2d23bfb6
content_type: application/pdf
creator: dernst
date_created: 2024-01-23T12:08:24Z
date_updated: 2024-01-23T12:08:24Z
file_id: '14877'
file_name: 2024_JourExperimBiology_Pal.pdf
file_size: 594128
relation: main_file
success: 1
file_date_updated: 2024-01-23T12:08:24Z
has_accepted_license: '1'
intvolume: ' 227'
isi: 1
issue: '1'
keyword:
- Insect Science
- Molecular Biology
- Animal Science and Zoology
- Aquatic Science
- Physiology
- Ecology
- Evolution
- Behavior and Systematics
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Experimental Biology
publication_identifier:
eissn:
- 0022-0949
issn:
- 1477-9145
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
related_material:
link:
- relation: software
url: https://github.com/arka-pal/Cnemaspis-SexualSignaling
scopus_import: '1'
status: public
title: Too much information? Males convey parasite levels using more signal modalities
than females utilise
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 227
year: '2024'
...
---
OA_place: publisher
_id: '15020'
abstract:
- lang: eng
text: "This thesis consists of four distinct pieces of work within theoretical biology,
with two themes in common: the concept of optimization in biological systems,
and the use of information-theoretic tools to quantify biological stochasticity
and statistical uncertainty.\r\nChapter 2 develops a statistical framework for
studying biological systems which we believe to be optimized for a particular
utility function, such as retinal neurons conveying information about visual stimuli.
We formalize such beliefs as maximum-entropy Bayesian priors, constrained by the
expected utility. We explore how such priors aid inference of system parameters
with limited data and enable optimality hypothesis testing: is the utility higher
than by chance?\r\nChapter 3 examines the ultimate biological optimization process:
evolution by natural selection. As some individuals survive and reproduce more
successfully than others, populations evolve towards fitter genotypes and phenotypes.
We formalize this as accumulation of genetic information, and use population genetics
theory to study how much such information can be accumulated per generation and
maintained in the face of random mutation and genetic drift. We identify the population
size and fitness variance as the key quantities that control information accumulation
and maintenance.\r\nChapter 4 reuses the concept of genetic information from Chapter
3, but from a different perspective: we ask how much genetic information organisms
actually need, in particular in the context of gene regulation. For example, how
much information is needed to bind transcription factors at correct locations
within the genome? Population genetics provides us with a refined answer: with
an increasing population size, populations achieve higher fitness by maintaining
more genetic information. Moreover, regulatory parameters experience selection
pressure to optimize the fitness-information trade-off, i.e. minimize the information
needed for a given fitness. This provides an evolutionary derivation of the optimization
priors introduced in Chapter 2.\r\nChapter 5 proves an upper bound on mutual information
between a signal and a communication channel output (such as neural activity).
Mutual information is an important utility measure for biological systems, but
its practical use can be difficult due to the large dimensionality of many biological
channels. Sometimes, a lower bound on mutual information is computed by replacing
the high-dimensional channel outputs with decodes (signal estimates). Our result
provides a corresponding upper bound, provided that the decodes are the maximum
posterior estimates of the signal."
acknowledged_ssus:
- _id: ScienComp
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Michal
full_name: Hledik, Michal
id: 4171253A-F248-11E8-B48F-1D18A9856A87
last_name: Hledik
citation:
ama: Hledik M. Genetic information and biological optimization. 2024. doi:10.15479/at:ista:15020
apa: Hledik, M. (2024). Genetic information and biological optimization.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:15020
chicago: Hledik, Michal. “Genetic Information and Biological Optimization.” Institute
of Science and Technology Austria, 2024. https://doi.org/10.15479/at:ista:15020.
ieee: M. Hledik, “Genetic information and biological optimization,” Institute of
Science and Technology Austria, 2024.
ista: Hledik M. 2024. Genetic information and biological optimization. Institute
of Science and Technology Austria.
mla: Hledik, Michal. Genetic Information and Biological Optimization. Institute
of Science and Technology Austria, 2024, doi:10.15479/at:ista:15020.
short: M. Hledik, Genetic Information and Biological Optimization, Institute of
Science and Technology Austria, 2024.
corr_author: '1'
date_created: 2024-02-23T14:02:04Z
date_published: 2024-02-23T00:00:00Z
date_updated: 2026-04-07T12:59:25Z
day: '23'
ddc:
- '576'
- '519'
degree_awarded: PhD
department:
- _id: GradSch
- _id: NiBa
- _id: GaTk
doi: 10.15479/at:ista:15020
ec_funded: 1
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creator: mhledik
date_created: 2024-02-23T13:50:53Z
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file_id: '15022'
file_name: hledik thesis source.zip
file_size: 14014790
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has_accepted_license: '1'
keyword:
- Theoretical biology
- Optimality
- Evolution
- Information
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: '158'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 2665AAFE-B435-11E9-9278-68D0E5697425
grant_number: RGP0034/2018
name: Can evolution minimize spurious signaling crosstalk to reach optimal performance?
- _id: bd6958e0-d553-11ed-ba76-86eba6a76c00
grant_number: '101055327'
name: Understanding the evolution of continuous genomes
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '7606'
relation: part_of_dissertation
status: public
- id: '12081'
relation: part_of_dissertation
status: public
- id: '7553'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
title: Genetic information and biological optimization
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2024'
...
---
_id: '15099'
abstract:
- lang: eng
text: Speciation is a key evolutionary process that is not yet fully understood.
Combining population genomic and ecological data from multiple diverging pairs
of marine snails (Littorina) supports the search for speciation mechanisms. Placing
pairs on a one-dimensional speciation continuum, from undifferentiated populations
to species, obscured the complexity of speciation. Adding multiple axes helped
to describe either speciation routes or reproductive isolation in the snails.
Divergent ecological selection repeatedly generated barriers between ecotypes,
but appeared less important in completing speciation while genetic incompatibilities
played a key role. Chromosomal inversions contributed to genomic barriers, but
with variable impact. A multidimensional (hypercube) approach supported framing
of questions and identification of knowledge gaps and can be useful to understand
speciation in many other systems.
acknowledgement: KJ, MR, and RKB were supported by grants from the Swedish Research
Council (2021-0419, 2021-05243, and 2018-03695, respectively). RKB was also supported
by the Leverhulme Trust (RPG-2021-141), RF by FCT- Portuguese Science Foundation
(PTDC/BIA-EVL/1614/2021 and 2020.00275.CEECIND), and AMW by Norwegian Research Council
RCN (Project number 315287). We thank the members of the Integration of Speciation
Research network for stimulating discussions, the Littorina research community for
important contributions of data and analyses, and Cynthia Riginos for useful comments
on an earlier draft.
article_processing_charge: Yes (in subscription journal)
article_type: review
author:
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
- first_name: Alan
full_name: Le Moan, Alan
last_name: Le Moan
- first_name: Marina
full_name: Rafajlović, Marina
last_name: Rafajlović
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Roger K.
full_name: Butlin, Roger K.
last_name: Butlin
- first_name: Sean
full_name: Stankowski, Sean
id: 43161670-5719-11EA-8025-FABC3DDC885E
last_name: Stankowski
citation:
ama: Johannesson K, Faria R, Le Moan A, et al. Diverse pathways to speciation revealed
by marine snails. Trends in Genetics. 2024;40(4):337-351. doi:10.1016/j.tig.2024.01.002
apa: Johannesson, K., Faria, R., Le Moan, A., Rafajlović, M., Westram, A. M., Butlin,
R. K., & Stankowski, S. (2024). Diverse pathways to speciation revealed by
marine snails. Trends in Genetics. Elsevier. https://doi.org/10.1016/j.tig.2024.01.002
chicago: Johannesson, Kerstin, Rui Faria, Alan Le Moan, Marina Rafajlović, Anja
M Westram, Roger K. Butlin, and Sean Stankowski. “Diverse Pathways to Speciation
Revealed by Marine Snails.” Trends in Genetics. Elsevier, 2024. https://doi.org/10.1016/j.tig.2024.01.002.
ieee: K. Johannesson et al., “Diverse pathways to speciation revealed by
marine snails,” Trends in Genetics, vol. 40, no. 4. Elsevier, pp. 337–351,
2024.
ista: Johannesson K, Faria R, Le Moan A, Rafajlović M, Westram AM, Butlin RK, Stankowski
S. 2024. Diverse pathways to speciation revealed by marine snails. Trends in Genetics.
40(4), 337–351.
mla: Johannesson, Kerstin, et al. “Diverse Pathways to Speciation Revealed by Marine
Snails.” Trends in Genetics, vol. 40, no. 4, Elsevier, 2024, pp. 337–51,
doi:10.1016/j.tig.2024.01.002.
short: K. Johannesson, R. Faria, A. Le Moan, M. Rafajlović, A.M. Westram, R.K. Butlin,
S. Stankowski, Trends in Genetics 40 (2024) 337–351.
date_created: 2024-03-10T23:00:54Z
date_published: 2024-04-01T00:00:00Z
date_updated: 2025-09-04T12:18:08Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1016/j.tig.2024.01.002
external_id:
isi:
- '001224671300001'
pmid:
- '38395682'
file:
- access_level: open_access
checksum: 3077ea808c4cdc24d02dc58aced7eb35
content_type: application/pdf
creator: dernst
date_created: 2024-07-22T12:05:58Z
date_updated: 2024-07-22T12:05:58Z
file_id: '17313'
file_name: 2024_TrendsGenetics_Johannesson.pdf
file_size: 2288340
relation: main_file
success: 1
file_date_updated: 2024-07-22T12:05:58Z
has_accepted_license: '1'
intvolume: ' 40'
isi: 1
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 337-351
pmid: 1
publication: Trends in Genetics
publication_identifier:
eissn:
- 1362-4555
issn:
- 0168-9525
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Diverse pathways to speciation revealed by marine snails
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 40
year: '2024'
...
---
_id: '15358'
abstract:
- lang: eng
text: 'We consider how a population of N haploid individuals responds to directional
selection on standing variation, with no new variation from recombination or mutation.
Individuals have trait values z1,…,zN, which are drawn from a distribution ψ;
the fitness of individual i is proportional to [Formula: see text] . For illustration,
we consider the Laplace and Gaussian distributions, which are parametrised only
by the variance V0, and show that for large N, there is a scaling limit which
depends on a single parameter NV0. When selection is weak relative to drift (NV0≪1),
the variance decreases exponentially at rate 1/N, and the expected ultimate gain
in log fitness (scaled by V0), is just NV0, which is the same as Robertson''s
(1960) prediction for a sexual population. In contrast, when selection is strong
relative to drift (NV0≫1), the ultimate gain can be found by approximating the
establishment of alleles by a branching process in which each allele competes
independently with the population mean and the fittest allele to establish is
certain to fix. Then, if the probability of survival to time t∼1/V0 of an allele
with value z is P(z), with mean P¯, the winning allele is the fittest of NP¯ survivors
drawn from a distribution ψP/P¯. The expected ultimate change is ∼2log(1.15NV0)
for a Gaussian distribution, and ∼-12log0.36NV0-log-log0.36NV0 for a Laplace distribution.
This approach also predicts the variability of the process, and its dynamics;
we show that in the strong selection regime, the expected genetic variance decreases
as ∼t-3 at large times. We discuss how these results may be related to selection
on standing variation that is spread along a linear chromosome.'
acknowledgement: We thank Emmanuel Schertzer and two reviewers for comments on this
manuscript. NB thanks the European Research Council for support via the grant “HaplotypeStructure”
101055327. We would also like to give our sincere thanks to Alison Etheridge for
her insight, inspiration and support over the years.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Himani
full_name: Sachdeva, Himani
id: 42377A0A-F248-11E8-B48F-1D18A9856A87
last_name: Sachdeva
citation:
ama: Barton NH, Sachdeva H. Limits to selection on standing variation in an asexual
population. Theoretical Population Biology. 2024;157:129-137. doi:10.1016/j.tpb.2024.04.001
apa: Barton, N. H., & Sachdeva, H. (2024). Limits to selection on standing variation
in an asexual population. Theoretical Population Biology. Elsevier. https://doi.org/10.1016/j.tpb.2024.04.001
chicago: Barton, Nicholas H, and Himani Sachdeva. “Limits to Selection on Standing
Variation in an Asexual Population.” Theoretical Population Biology. Elsevier,
2024. https://doi.org/10.1016/j.tpb.2024.04.001.
ieee: N. H. Barton and H. Sachdeva, “Limits to selection on standing variation in
an asexual population,” Theoretical Population Biology, vol. 157. Elsevier,
pp. 129–137, 2024.
ista: Barton NH, Sachdeva H. 2024. Limits to selection on standing variation in
an asexual population. Theoretical Population Biology. 157, 129–137.
mla: Barton, Nicholas H., and Himani Sachdeva. “Limits to Selection on Standing
Variation in an Asexual Population.” Theoretical Population Biology, vol.
157, Elsevier, 2024, pp. 129–37, doi:10.1016/j.tpb.2024.04.001.
short: N.H. Barton, H. Sachdeva, Theoretical Population Biology 157 (2024) 129–137.
corr_author: '1'
date_created: 2024-05-05T22:01:03Z
date_published: 2024-06-01T00:00:00Z
date_updated: 2025-09-04T13:56:11Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1016/j.tpb.2024.04.001
external_id:
isi:
- '001237016800001'
pmid:
- '38643838'
file:
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checksum: 78f36488d24f868d5913624e9c8d88bf
content_type: application/pdf
creator: dernst
date_created: 2024-05-13T08:22:21Z
date_updated: 2024-05-13T08:22:21Z
file_id: '15383'
file_name: 2024_TheorPopulationBiology_Barton.pdf
file_size: 1098292
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language:
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oa: 1
oa_version: Published Version
page: 129-137
pmid: 1
project:
- _id: bd6958e0-d553-11ed-ba76-86eba6a76c00
grant_number: '101055327'
name: Understanding the evolution of continuous genomes
publication: Theoretical Population Biology
publication_identifier:
eissn:
- 1096-0325
issn:
- 0040-5809
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Limits to selection on standing variation in an asexual population
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 157
year: '2024'
...
---
APC_amount: 4569,23 EUR
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '18491'
abstract:
- lang: eng
text: Predicting the outcomes of adaptation is a major goal of evolutionary biology.
When temporal changes in the environment mirror spatial gradients, it opens up
the potential for predicting the course of adaptive evolution over time based
on patterns of spatial genetic and phenotypic variation. We assessed this approach
in a 30-year transplant experiment in the intertidal snail Littorina saxatilis.
In 1992, snails were transplanted from a predation-dominated environment to one
dominated by wave action. On the basis of spatial patterns, we predicted transitions
in shell size and morphology, allele frequencies at positions throughout the genome,
and chromosomal rearrangement frequencies. Observed changes closely agreed with
predictions and transformation was both dramatic and rapid. Hence, adaptation
can be predicted from knowledge of the phenotypic and genetic variation among
populations.
acknowledgement: 'This work was received funding from the following: Norwegian Research
Council RCN project 315287 (A.M.W.), Swedish Research Council 2021-04191 (K.J.),
European Research Council grant 101055327 HaplotypeStructure (N.B.), Austrian Science
Fund FWF; P 32166-B32 Snapdragon Speciation (N.B.), European Research Council (R.B.),
and Portuguese Foundation for Science and Technology FCT: 2020.00275.CEECIND and
PTDC/BIA-EVL/1614/2021 (R.F.).'
article_number: eadp2102
article_processing_charge: Yes
article_type: original
author:
- first_name: Diego Fernando
full_name: Garcia Castillo, Diego Fernando
id: ae681a14-dc74-11ea-a0a7-c6ef18161701
last_name: Garcia Castillo
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
- first_name: Jenny
full_name: Larsson, Jenny
last_name: Larsson
- first_name: Sean
full_name: Stankowski, Sean
id: 43161670-5719-11EA-8025-FABC3DDC885E
last_name: Stankowski
- first_name: Roger
full_name: Butlin, Roger
last_name: Butlin
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
citation:
ama: 'Garcia Castillo DF, Barton NH, Faria R, et al. Predicting rapid adaptation
in time from adaptation in space: A 30-year field experiment in marine snails.
Science Advances. 2024;10(41). doi:10.1126/sciadv.adp2102'
apa: 'Garcia Castillo, D. F., Barton, N. H., Faria, R., Larsson, J., Stankowski,
S., Butlin, R., … Westram, A. M. (2024). Predicting rapid adaptation in time from
adaptation in space: A 30-year field experiment in marine snails. Science Advances.
AAAS. https://doi.org/10.1126/sciadv.adp2102'
chicago: 'Garcia Castillo, Diego Fernando, Nicholas H Barton, Rui Faria, Jenny Larsson,
Sean Stankowski, Roger Butlin, Kerstin Johannesson, and Anja M Westram. “Predicting
Rapid Adaptation in Time from Adaptation in Space: A 30-Year Field Experiment
in Marine Snails.” Science Advances. AAAS, 2024. https://doi.org/10.1126/sciadv.adp2102.'
ieee: 'D. F. Garcia Castillo et al., “Predicting rapid adaptation in time
from adaptation in space: A 30-year field experiment in marine snails,” Science
Advances, vol. 10, no. 41. AAAS, 2024.'
ista: 'Garcia Castillo DF, Barton NH, Faria R, Larsson J, Stankowski S, Butlin R,
Johannesson K, Westram AM. 2024. Predicting rapid adaptation in time from adaptation
in space: A 30-year field experiment in marine snails. Science Advances. 10(41),
eadp2102.'
mla: 'Garcia Castillo, Diego Fernando, et al. “Predicting Rapid Adaptation in Time
from Adaptation in Space: A 30-Year Field Experiment in Marine Snails.” Science
Advances, vol. 10, no. 41, eadp2102, AAAS, 2024, doi:10.1126/sciadv.adp2102.'
short: D.F. Garcia Castillo, N.H. Barton, R. Faria, J. Larsson, S. Stankowski, R.
Butlin, K. Johannesson, A.M. Westram, Science Advances 10 (2024).
corr_author: '1'
date_created: 2024-11-03T23:01:44Z
date_published: 2024-10-11T00:00:00Z
date_updated: 2026-04-07T11:42:09Z
day: '11'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1126/sciadv.adp2102
external_id:
isi:
- '001354405400018'
file:
- access_level: open_access
checksum: 96aa0d3640fa9401975138e59054f84e
content_type: application/pdf
creator: dernst
date_created: 2024-11-04T09:35:49Z
date_updated: 2024-11-04T09:35:49Z
file_id: '18499'
file_name: 2024_ScienceAdv_Castillo.pdf
file_size: 1154107
relation: main_file
success: 1
file_date_updated: 2024-11-04T09:35:49Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
issue: '41'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: bd6958e0-d553-11ed-ba76-86eba6a76c00
grant_number: '101055327'
name: Understanding the evolution of continuous genomes
- _id: 05959E1C-7A3F-11EA-A408-12923DDC885E
grant_number: P32166
name: Snapdragon Speciation
- _id: 3AC91DDA-15DF-11EA-824D-93A3E7B544D1
call_identifier: FWF
name: FWF Open Access Fund
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
related_material:
link:
- relation: software
url: https://github.com/fernandoGarcia21/littorina_saxatilis_skerry
record:
- id: '18498'
relation: research_data
status: public
- id: '20991'
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scopus_import: '1'
status: public
title: 'Predicting rapid adaptation in time from adaptation in space: A 30-year field
experiment in marine snails'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 10
year: '2024'
...
---
OA_place: repository
_id: '18498'
abstract:
- lang: eng
text: 'Scripts and data used in the research study Predicting rapid adaptation in
time from adaptation in space: a 30-year field experiment in marine snails. https://doi.org/10.1101/2023.09.27.559715'
article_processing_charge: No
author:
- first_name: Diego Fernando
full_name: Garcia Castillo, Diego Fernando
id: ae681a14-dc74-11ea-a0a7-c6ef18161701
last_name: Garcia Castillo
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
- first_name: Jenny
full_name: Larsson, Jenny
last_name: Larsson
- first_name: Sean
full_name: Stankowski, Sean
id: 43161670-5719-11EA-8025-FABC3DDC885E
last_name: Stankowski
- first_name: Roger
full_name: Butlin, Roger
last_name: Butlin
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
citation:
ama: 'Garcia Castillo DF, Barton NH, Faria R, et al. Data and code for: Predicting
rapid adaptation in time from adaptation in space: a 30-year field experiment
in marine snails. 2024. doi:10.5281/ZENODO.12159343'
apa: 'Garcia Castillo, D. F., Barton, N. H., Faria, R., Larsson, J., Stankowski,
S., Butlin, R., … Westram, A. M. (2024). Data and code for: Predicting rapid adaptation
in time from adaptation in space: a 30-year field experiment in marine snails.
Zenodo. https://doi.org/10.5281/ZENODO.12159343'
chicago: 'Garcia Castillo, Diego Fernando, Nicholas H Barton, Rui Faria, Jenny Larsson,
Sean Stankowski, Roger Butlin, Kerstin Johannesson, and Anja M Westram. “Data
and Code for: Predicting Rapid Adaptation in Time from Adaptation in Space: A
30-Year Field Experiment in Marine Snails.” Zenodo, 2024. https://doi.org/10.5281/ZENODO.12159343.'
ieee: 'D. F. Garcia Castillo et al., “Data and code for: Predicting rapid
adaptation in time from adaptation in space: a 30-year field experiment in marine
snails.” Zenodo, 2024.'
ista: 'Garcia Castillo DF, Barton NH, Faria R, Larsson J, Stankowski S, Butlin R,
Johannesson K, Westram AM. 2024. Data and code for: Predicting rapid adaptation
in time from adaptation in space: a 30-year field experiment in marine snails,
Zenodo, 10.5281/ZENODO.12159343.'
mla: 'Garcia Castillo, Diego Fernando, et al. Data and Code for: Predicting Rapid
Adaptation in Time from Adaptation in Space: A 30-Year Field Experiment in Marine
Snails. Zenodo, 2024, doi:10.5281/ZENODO.12159343.'
short: D.F. Garcia Castillo, N.H. Barton, R. Faria, J. Larsson, S. Stankowski, R.
Butlin, K. Johannesson, A.M. Westram, (2024).
corr_author: '1'
date_created: 2024-11-04T09:33:17Z
date_published: 2024-06-19T00:00:00Z
date_updated: 2026-04-16T12:20:37Z
day: '19'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.5281/ZENODO.12159343
has_accepted_license: '1'
main_file_link:
- open_access: '1'
url: https://doi.org/10.5281/zenodo.12159344
month: '06'
oa: 1
oa_version: Published Version
publisher: Zenodo
related_material:
record:
- id: '20991'
relation: used_in_publication
status: public
- id: '18491'
relation: used_in_publication
status: public
status: public
title: 'Data and code for: Predicting rapid adaptation in time from adaptation in
space: a 30-year field experiment in marine snails'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2024'
...
---
OA_place: publisher
OA_type: gold
_id: '18515'
abstract:
- lang: eng
text: "Understanding the role of evolutionary processes in shaping genetic variation
has been a\r\nprimary goal in evolutionary genetics. In this regard, a key question
is how genetically\r\ndistinct populations evolve in the face of gene flow, thereby
generating genetic and\r\nphenotypic divergence and reproductive isolation (RI).
This requires quantifying the role\r\nand relative contributions of prezygotic
and postzygotic isolating mechanisms on the\r\nreduction of gene exchange between
populations, and identifying regions in the genome\r\nthat mediate RI, which is
often polygenic. Further, this needs distinguishing neutral and\r\nselected regions
in the genome, and discerning how selection influences patterns of neutral\r\ndivergence.\r\nPopulation
structure, defined as any deviation from panmixia, such as geographic distribution,
movement and mating patterns of individuals, influences how genetic variation
is\r\nstructured in space and shapes the neutral null model. Availability of large
scale spatial\r\ngenomic datasets now enables us to detect signatures of population
structure in genetic\r\ndata and infer population genetic parameters. Such inferences
are crucial and have wide\r\napplications in biodiversity, conservation genetics,
population management and medical\r\ngenetics. However, inferences are based on
assumptions that do not always match the\r\ncomplex reality, thus leading to erroneous
conclusions. Moreover, the role and interaction\r\nof heterogeneous population
density and dispersal, which are ubiquitous in nature, has\r\nbeen challenging
to study owing to their mathematical complexity. In such scenarios,\r\nfeedback
between theory, data and simulations can prove to be useful.\r\nIn this thesis,
I examine the effect of population structure on neutral genetic variation\r\nand
barriers to gene exchange in hybridising populations, thereby bridging together
the\r\nfields of spatial population genetics and speciation.\r\nDespite being
a key concept in speciation, reproductive isolation (RI) lacks a quantitative\r\ndefinition
and has been used and measured differently across different fields. Chapter 2\r\ngives
a quantitative definition of RI, in terms of the effect of genetic differences
on gene\r\nflow. We give analytical predictions for RI in a range of scenarios,
in terms of effective migration rates for discrete populations and barrier strength
for continuous populations.\r\nIn addition to this, we discuss current measures
of RI and their limitations, and propose\r\nthe need for new measures that combine
organismal and genetic perspectives of RI.\r\nIn chapter 3, I examine the combined
effect of assortative mating, sexual selection\r\nand viability selection on RI.
For this, we consider a polygenic ‘magic’ trait under a\r\nmainland-island model.
We obtain novel theoretical predictions for molecular divergence\r\nin terms of
effective migration rates, which bears a simple relationship to measurable\r\nfitness
components of migrants and various early generation hybrids. We explore the\r\nconditions
under which local adaptation can be maintained despite maladaptive gene flow\r\nand
quantify the relative contributions of viability and sexual selection to genome-wide\r\nbarriers
to gene flow.\r\nThe next two chapters of the thesis focus on a hybrid zone of
Antirrhinum majus that\r\nconsist of two subspecies- the magenta flowered A. m.
pseudomajus and the yellow\r\nflowered A.m. striatum. Previous studies have suggested
that flower colour is target of\r\npollinator mediated selection and is influenced
only by few genes. While these regions\r\nshow high genetic differentiation between
the subspecies, the rest of the genome is seen\r\nto be well mixed. Chapter 4
examines the effects of heterogeneous population density\r\nand leptokurtic dispersal
on isolation by distance and the distribution of heterozygosity\r\nby focusing
on non-flower colour markers.\r\nChapter 5 analyses cline shapes and associations
among 6 focal flower colour markers to\r\nunderstand how selection and dispersal
maintain this hybrid zone. We see sharp coincident\r\nstepped clines at all loci
and positive associations throughout the hybrid zone, contrary to\r\nthe expected
patterns from diffusive gene flow. With a novel scheme of inferring dispersal\r\ncombined
with multilocus simulations, we show that stepped clines do not reflect genetic\r\nbarriers
to gene flow, but are rather a result of long-distance migration. This framework\r\nallows
us to get realistic estimates gene flow and selection and shows how traditional
cline\r\nanalysis may lead to inaccurate conclusions when assumptions of the theory
are not met.\r\nOverall, this thesis investigates how different features of population
structure leave\r\ndetectable signatures in genetic variation, namely in patterns
of isolation by distance,\r\nlinkage disequilibrium and genetic divergence. It
also highlights how effective migration\r\nrates provide useful way of analysing
polygenic architectures and shed new light into\r\nhybrid zones. In doing so,
I identify scenarios when simple models become insufficient\r\nand suggest possibe
directions by combining genetic data with simulations."
acknowledged_ssus:
- _id: ScienComp
acknowledgement: "I also acknowledge the funding agencies Marie Curie COFUND Doctoral
Fellowship,\r\nAustrian Science Fund FWF (grant P32166) and ERC (grant PR1000ERC02)
for financially\r\nsupporting my research over the years."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Parvathy
full_name: Surendranadh, Parvathy
id: 455235B8-F248-11E8-B48F-1D18A9856A87
last_name: Surendranadh
orcid: 0000-0001-6395-386X
citation:
ama: Surendranadh P. Effect of population structure on neutral genetic variation
and barriers to gene exchange. 2024. doi:10.15479/at:ista:18515
apa: Surendranadh, P. (2024). Effect of population structure on neutral genetic
variation and barriers to gene exchange. Institute of Science and Technology
Austria. https://doi.org/10.15479/at:ista:18515
chicago: Surendranadh, Parvathy. “Effect of Population Structure on Neutral Genetic
Variation and Barriers to Gene Exchange.” Institute of Science and Technology
Austria, 2024. https://doi.org/10.15479/at:ista:18515.
ieee: P. Surendranadh, “Effect of population structure on neutral genetic variation
and barriers to gene exchange,” Institute of Science and Technology Austria, 2024.
ista: Surendranadh P. 2024. Effect of population structure on neutral genetic variation
and barriers to gene exchange. Institute of Science and Technology Austria.
mla: Surendranadh, Parvathy. Effect of Population Structure on Neutral Genetic
Variation and Barriers to Gene Exchange. Institute of Science and Technology
Austria, 2024, doi:10.15479/at:ista:18515.
short: P. Surendranadh, Effect of Population Structure on Neutral Genetic Variation
and Barriers to Gene Exchange, Institute of Science and Technology Austria, 2024.
corr_author: '1'
date_created: 2024-11-06T21:25:37Z
date_published: 2024-11-07T00:00:00Z
date_updated: 2026-04-07T12:56:52Z
day: '07'
ddc:
- '576'
degree_awarded: PhD
department:
- _id: GradSch
- _id: NiBa
doi: 10.15479/at:ista:18515
file:
- access_level: open_access
checksum: c32cf7bc75748d9c551d8eb70178bbec
content_type: application/pdf
creator: psurendr
date_created: 2024-11-07T10:59:29Z
date_updated: 2024-11-07T10:59:29Z
file_id: '18519'
file_name: PhD_Thesis__Parvathy_071124_PDFA.pdf
file_size: 37019760
relation: main_file
success: 1
- access_level: closed
checksum: 4417e02d54084d89e75734e18caaa96d
content_type: application/zip
creator: psurendr
date_created: 2024-11-07T10:59:42Z
date_updated: 2024-11-07T10:59:42Z
file_id: '18520'
file_name: PhD Thesis- Parvathy_071124.zip
file_size: 41198857
relation: source_file
file_date_updated: 2024-11-07T10:59:42Z
has_accepted_license: '1'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: '219'
project:
- _id: 05959E1C-7A3F-11EA-A408-12923DDC885E
grant_number: P32166
name: Snapdragon Speciation
- _id: bd6958e0-d553-11ed-ba76-86eba6a76c00
grant_number: '101055327'
name: Understanding the evolution of continuous genomes
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
title: Effect of population structure on neutral genetic variation and barriers to
gene exchange
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2024'
...
---
OA_place: publisher
OA_type: gold
_id: '18908'
abstract:
- lang: eng
text: Chromosomal rearrangements can lead to the coupling of reproductive barriers,
but whether and how they contribute to the completion of speciation remains unclear.
Marine snails of the genus Littorina repeatedly form hybrid zones between populations
segregating for multiple inversion arrangements, providing opportunities to study
their barrier effects. Here, we analyzed 2 adjacent transects across hybrid zones
between 2 ecotypes of Littorina fabalis (“large” and “dwarf”) adapted to different
wave exposure conditions on a Swedish island. Applying whole-genome sequencing,
we found 12 putative inversions on 9 of 17 chromosomes. Nine of the putative inversions
reached near differential fixation between the 2 ecotypes, and all were in strong
linkage disequilibrium. These inversions cover 20% of the genome and carry 93%
of divergent single nucleotide polymorphisms (SNPs). Bimodal hybrid zones in both
transects indicated that the 2 ecotypes of Littorina fabalis maintain their genetic
and phenotypic integrity following contact. The bimodality reflects the strong
coupling between inversion clines and the extension of the barrier effect across
the whole genome. Demographic inference suggests that coupling arose during a
period of allopatry and has been maintained for > 1,000 generations after
secondary contact. Overall, this study shows that the coupling of multiple chromosomal
inversions contributes to strong reproductive isolation. Notably, 2 of the putative
inversions overlap with inverted genomic regions associated with ecotype differences
in a closely related species (Littorina saxatilis), suggesting the same regions,
with similar structural variants, repeatedly contribute to ecotype evolution in
distinct species.
acknowledgement: The computations and data handling were enabled by resources provided
by the Swedish National Infrastructure for Computing at UPPMAX partially funded
by the Swedish Research Council through grant agreement no. 2018-05973. We thank
all the member of the Littorina team for the stimulating discussions about the manuscripts,
James Reeves for his help the implementation of Hsplit, and Thomas Broquet for his
useful comments in the latter stage of manuscript revisions.
article_processing_charge: Yes
article_type: letter_note
author:
- first_name: Alan
full_name: Le Moan, Alan
last_name: Le Moan
- first_name: Sean
full_name: Stankowski, Sean
id: 43161670-5719-11EA-8025-FABC3DDC885E
last_name: Stankowski
- first_name: Marina
full_name: Rafajlović, Marina
last_name: Rafajlović
- first_name: Olga
full_name: Ortega-Martinez, Olga
last_name: Ortega-Martinez
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
- first_name: Roger K
full_name: Butlin, Roger K
last_name: Butlin
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
citation:
ama: Le Moan A, Stankowski S, Rafajlović M, et al. Coupling of twelve putative chromosomal
inversions maintains a strong barrier to gene flow between snail ecotypes. Evolution
Letters. 2024;8(4):575-586. doi:10.1093/evlett/qrae014
apa: Le Moan, A., Stankowski, S., Rafajlović, M., Ortega-Martinez, O., Faria, R.,
Butlin, R. K., & Johannesson, K. (2024). Coupling of twelve putative chromosomal
inversions maintains a strong barrier to gene flow between snail ecotypes. Evolution
Letters. Oxford University Press. https://doi.org/10.1093/evlett/qrae014
chicago: Le Moan, Alan, Sean Stankowski, Marina Rafajlović, Olga Ortega-Martinez,
Rui Faria, Roger K Butlin, and Kerstin Johannesson. “Coupling of Twelve Putative
Chromosomal Inversions Maintains a Strong Barrier to Gene Flow between Snail Ecotypes.”
Evolution Letters. Oxford University Press, 2024. https://doi.org/10.1093/evlett/qrae014.
ieee: A. Le Moan et al., “Coupling of twelve putative chromosomal inversions
maintains a strong barrier to gene flow between snail ecotypes,” Evolution
Letters, vol. 8, no. 4. Oxford University Press, pp. 575–586, 2024.
ista: Le Moan A, Stankowski S, Rafajlović M, Ortega-Martinez O, Faria R, Butlin
RK, Johannesson K. 2024. Coupling of twelve putative chromosomal inversions maintains
a strong barrier to gene flow between snail ecotypes. Evolution Letters. 8(4),
575–586.
mla: Le Moan, Alan, et al. “Coupling of Twelve Putative Chromosomal Inversions Maintains
a Strong Barrier to Gene Flow between Snail Ecotypes.” Evolution Letters,
vol. 8, no. 4, Oxford University Press, 2024, pp. 575–86, doi:10.1093/evlett/qrae014.
short: A. Le Moan, S. Stankowski, M. Rafajlović, O. Ortega-Martinez, R. Faria, R.K.
Butlin, K. Johannesson, Evolution Letters 8 (2024) 575–586.
date_created: 2025-01-27T13:30:27Z
date_published: 2024-04-23T00:00:00Z
date_updated: 2025-09-09T12:05:51Z
day: '23'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1093/evlett/qrae014
external_id:
isi:
- '001206532900001'
pmid:
- '39479507'
file:
- access_level: open_access
checksum: 2f7780b7b6b3489755f1815f476639c6
content_type: application/pdf
creator: dernst
date_created: 2025-01-27T13:33:14Z
date_updated: 2025-01-27T13:33:14Z
file_id: '18909'
file_name: 2024_EvolutionLetter_Moan.pdf
file_size: 24356661
relation: main_file
success: 1
file_date_updated: 2025-01-27T13:33:14Z
has_accepted_license: '1'
intvolume: ' 8'
isi: 1
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 575-586
pmid: 1
publication: Evolution Letters
publication_identifier:
issn:
- 2056-3744
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Coupling of twelve putative chromosomal inversions maintains a strong barrier
to gene flow between snail ecotypes
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 8
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '18944'
abstract:
- lang: eng
text: 'Understanding connectivity patterns exhibited by endangered species living
in fragmented habitats is fundamental to improving management and conservation
actions. Such improvements can be particularly pressing at the trailing edges
of these habitats, where populations are facing the greatest challenges from climate
change, and appear even more crucial if the species is commercially harvested.
Seascape genetics have been increasingly used to meet these needs. In this study,
we examined connectivity patterns among 32 populations of the oarweed kelp Laminaria
digitata located at the species’ southern range limit. The distance
(or sampling gap) between neighboring populations ranged from a few km to a few
100s of km. By genotyping 11 microsatellite markers, we aimed to (1) refine analyses
of population structure; (2) test whether on-shelf islands are genetically more
differentiated than mainland populations; (3) evaluate the relative importance
of various abiotic conditions in shaping the genetic structure; and (4) evaluate
if the relative importance of each environmental factor varied according to sampling
schemes. Our analyses revealed a positive relationship between connectivity links
and genetic diversity: populations with high levels of connectivity were genetically
enriched while isolated populations showed signs of genetic erosion. The genetically
impoverished populations corresponded to the southernmost populations as well
as populations along the northern coast of Brittany (Locquirec, Saint-Malo Bay)
and the northernmost population in Pas-de-Calais. By performing distance-based
redundancy analysis on various sampling schemes, geographic distance appeared
as the dominant factor influencing connectivity between populations separated
by great distances, while hydrodynamic processes were the main factor when analyzing
at a final spatial resolution.'
article_processing_charge: No
article_type: original
author:
- first_name: Louise
full_name: Fouqueau, Louise
id: 1676e173-8143-11ed-8927-fe165216a93f
last_name: Fouqueau
orcid: 0000-0003-0371-9339
- first_name: L
full_name: Reynes, L
last_name: Reynes
- first_name: F
full_name: Tempera, F
last_name: Tempera
- first_name: T
full_name: Bajjouk, T
last_name: Bajjouk
- first_name: A
full_name: Blanfuné, A
last_name: Blanfuné
- first_name: C
full_name: Chevalier, C
last_name: Chevalier
- first_name: M
full_name: Laurans, M
last_name: Laurans
- first_name: S
full_name: Mauger, S
last_name: Mauger
- first_name: M
full_name: Sourisseau, M
last_name: Sourisseau
- first_name: J
full_name: Assis, J
last_name: Assis
- first_name: L
full_name: Lévêque, L
last_name: Lévêque
- first_name: M
full_name: Valero, M
last_name: Valero
citation:
ama: Fouqueau L, Reynes L, Tempera F, et al. Seascape genetic study on Laminaria
digitata underscores the critical role of sampling schemes. Marine Ecology
Progress Series. 2024;740:23-42. doi:10.3354/meps14640
apa: Fouqueau, L., Reynes, L., Tempera, F., Bajjouk, T., Blanfuné, A., Chevalier,
C., … Valero, M. (2024). Seascape genetic study on Laminaria digitata underscores
the critical role of sampling schemes. Marine Ecology Progress Series.
Inter-Research Science Center. https://doi.org/10.3354/meps14640
chicago: Fouqueau, Louise, L Reynes, F Tempera, T Bajjouk, A Blanfuné, C Chevalier,
M Laurans, et al. “Seascape Genetic Study on Laminaria Digitata Underscores the
Critical Role of Sampling Schemes.” Marine Ecology Progress Series. Inter-Research
Science Center, 2024. https://doi.org/10.3354/meps14640.
ieee: L. Fouqueau et al., “Seascape genetic study on Laminaria digitata underscores
the critical role of sampling schemes,” Marine Ecology Progress Series,
vol. 740. Inter-Research Science Center, pp. 23–42, 2024.
ista: Fouqueau L, Reynes L, Tempera F, Bajjouk T, Blanfuné A, Chevalier C, Laurans
M, Mauger S, Sourisseau M, Assis J, Lévêque L, Valero M. 2024. Seascape genetic
study on Laminaria digitata underscores the critical role of sampling schemes.
Marine Ecology Progress Series. 740, 23–42.
mla: Fouqueau, Louise, et al. “Seascape Genetic Study on Laminaria Digitata Underscores
the Critical Role of Sampling Schemes.” Marine Ecology Progress Series,
vol. 740, Inter-Research Science Center, 2024, pp. 23–42, doi:10.3354/meps14640.
short: L. Fouqueau, L. Reynes, F. Tempera, T. Bajjouk, A. Blanfuné, C. Chevalier,
M. Laurans, S. Mauger, M. Sourisseau, J. Assis, L. Lévêque, M. Valero, Marine
Ecology Progress Series 740 (2024) 23–42.
corr_author: '1'
date_created: 2025-01-29T09:09:10Z
date_published: 2024-07-25T00:00:00Z
date_updated: 2025-01-29T09:12:34Z
day: '25'
department:
- _id: NiBa
doi: 10.3354/meps14640
intvolume: ' 740'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://inria.hal.science/hal-04624490/
month: '07'
oa: 1
oa_version: Submitted Version
page: 23-42
publication: Marine Ecology Progress Series
publication_identifier:
eissn:
- 1616-1599
issn:
- 0171-8630
publication_status: published
publisher: Inter-Research Science Center
quality_controlled: '1'
scopus_import: '1'
status: public
title: Seascape genetic study on Laminaria digitata underscores the critical role
of sampling schemes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 740
year: '2024'
...
---
OA_place: publisher
OA_type: gold
_id: '18949'
abstract:
- lang: eng
text: 'Speciation research—the scientific field focused on understanding the origin
and diversity of species—has a long and complex history. While relevant to one
another, the specific goals and activities of speciation researchers are highly
diverse, and scattered across a collection of different perspectives. Thus, our
understanding of speciation will benefit from efforts to bridge scientific findings
and the diverse people who do the work. In this paper, we outline two ways of
integrating speciation research: (i) scientific integration, through the bringing
together of ideas, data, and approaches; and (ii) social integration, by creating
ways for a diversity of researchers to participate in the scientific process.
We then discuss five challenges to integration: (i) the multidisciplinary nature
of speciation research, (ii) the complex language of speciation; (iii) a bias
toward certain study systems; (iv) the challenges of working across scales; and
(v) inconsistent measures and reporting standards. We provide practical steps
that individuals and groups can take to help overcome these challenges, and argue
that integration is a team effort in which we all have a role to play.'
acknowledgement: "We thank the staff of the Tvärminne Zoological Station (University
of Helsinki) for their hospitality during the workshop. We are also grateful to
everyone who applied to attend the workshop.\r\nFunding for the workshop was provided
by the European Society for Evolutionary Biology through the Special Topic Network
(STN) funding scheme."
article_number: kzae001
article_processing_charge: Yes
article_type: original
author:
- first_name: Sean
full_name: Stankowski, Sean
id: 43161670-5719-11EA-8025-FABC3DDC885E
last_name: Stankowski
- first_name: Asher D
full_name: Cutter, Asher D
last_name: Cutter
- first_name: Ina
full_name: Satokangas, Ina
last_name: Satokangas
- first_name: Brian A
full_name: Lerch, Brian A
last_name: Lerch
- first_name: Jonathan
full_name: Rolland, Jonathan
last_name: Rolland
- first_name: Carole M
full_name: Smadja, Carole M
last_name: Smadja
- first_name: J Carolina
full_name: Segami Marzal, J Carolina
last_name: Segami Marzal
- first_name: Christopher R
full_name: Cooney, Christopher R
last_name: Cooney
- first_name: Philine G D
full_name: Feulner, Philine G D
last_name: Feulner
- first_name: Fabricius Maia Chaves Bicalho
full_name: Domingos, Fabricius Maia Chaves Bicalho
last_name: Domingos
- first_name: Henry L
full_name: North, Henry L
last_name: North
- first_name: Ryo
full_name: Yamaguchi, Ryo
last_name: Yamaguchi
- first_name: Roger K
full_name: Butlin, Roger K
last_name: Butlin
- first_name: Jochen B W
full_name: Wolf, Jochen B W
last_name: Wolf
- first_name: Jenn
full_name: Coughlan, Jenn
last_name: Coughlan
- first_name: Patrick
full_name: Heidbreder, Patrick
last_name: Heidbreder
- first_name: Rebeca
full_name: Hernández-Gutiérrez, Rebeca
last_name: Hernández-Gutiérrez
- first_name: Karen B
full_name: Barnard-Kubow, Karen B
last_name: Barnard-Kubow
- first_name: David
full_name: Peede, David
last_name: Peede
- first_name: Loïs
full_name: Rancilhac, Loïs
last_name: Rancilhac
- first_name: Rodrigo Brincalepe
full_name: Salvador, Rodrigo Brincalepe
last_name: Salvador
- first_name: Ken A
full_name: Thompson, Ken A
last_name: Thompson
- first_name: Elizabeth A
full_name: Stacy, Elizabeth A
last_name: Stacy
- first_name: Leonie C
full_name: Moyle, Leonie C
last_name: Moyle
- first_name: Martin D
full_name: Garlovsky, Martin D
last_name: Garlovsky
- first_name: Arif
full_name: Maulana, Arif
last_name: Maulana
- first_name: Annina
full_name: Kantelinen, Annina
last_name: Kantelinen
- first_name: N Ivalú
full_name: Cacho, N Ivalú
last_name: Cacho
- first_name: Hilde
full_name: Schneemann, Hilde
last_name: Schneemann
- first_name: Marisol
full_name: Domínguez, Marisol
last_name: Domínguez
- first_name: Erik B
full_name: Dopman, Erik B
last_name: Dopman
- first_name: Konrad
full_name: Lohse, Konrad
last_name: Lohse
- first_name: Sina J
full_name: Rometsch, Sina J
last_name: Rometsch
- first_name: Aaron A
full_name: Comeault, Aaron A
last_name: Comeault
- first_name: Richard M
full_name: Merrill, Richard M
last_name: Merrill
- first_name: Elizabeth S C
full_name: Scordato, Elizabeth S C
last_name: Scordato
- first_name: Sonal
full_name: Singhal, Sonal
last_name: Singhal
- first_name: Varpu
full_name: Pärssinen, Varpu
last_name: Pärssinen
- first_name: Alycia C R
full_name: Lackey, Alycia C R
last_name: Lackey
- first_name: Sanghamitra
full_name: Kumar, Sanghamitra
last_name: Kumar
- first_name: Joana I
full_name: Meier, Joana I
last_name: Meier
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Christelle
full_name: Fraisse, Christelle
id: 32DF5794-F248-11E8-B48F-1D18A9856A87
last_name: Fraisse
orcid: 0000-0001-8441-5075
- first_name: Mark
full_name: Ravinet, Mark
last_name: Ravinet
- first_name: Jonna
full_name: Kulmuni, Jonna
last_name: Kulmuni
citation:
ama: Stankowski S, Cutter AD, Satokangas I, et al. Toward the integration of speciation
research. Evolutionary Journal of the Linnean Society. 2024;3(1). doi:10.1093/evolinnean/kzae001
apa: Stankowski, S., Cutter, A. D., Satokangas, I., Lerch, B. A., Rolland, J., Smadja,
C. M., … Kulmuni, J. (2024). Toward the integration of speciation research. Evolutionary
Journal of the Linnean Society. Oxford University Press. https://doi.org/10.1093/evolinnean/kzae001
chicago: Stankowski, Sean, Asher D Cutter, Ina Satokangas, Brian A Lerch, Jonathan
Rolland, Carole M Smadja, J Carolina Segami Marzal, et al. “Toward the Integration
of Speciation Research.” Evolutionary Journal of the Linnean Society. Oxford
University Press, 2024. https://doi.org/10.1093/evolinnean/kzae001.
ieee: S. Stankowski et al., “Toward the integration of speciation research,”
Evolutionary Journal of the Linnean Society, vol. 3, no. 1. Oxford University
Press, 2024.
ista: Stankowski S, Cutter AD, Satokangas I, Lerch BA, Rolland J, Smadja CM, Segami
Marzal JC, Cooney CR, Feulner PGD, Domingos FMCB, North HL, Yamaguchi R, Butlin
RK, Wolf JBW, Coughlan J, Heidbreder P, Hernández-Gutiérrez R, Barnard-Kubow KB,
Peede D, Rancilhac L, Salvador RB, Thompson KA, Stacy EA, Moyle LC, Garlovsky
MD, Maulana A, Kantelinen A, Cacho NI, Schneemann H, Domínguez M, Dopman EB, Lohse
K, Rometsch SJ, Comeault AA, Merrill RM, Scordato ESC, Singhal S, Pärssinen V,
Lackey ACR, Kumar S, Meier JI, Barton NH, Fraisse C, Ravinet M, Kulmuni J. 2024.
Toward the integration of speciation research. Evolutionary Journal of the Linnean
Society. 3(1), kzae001.
mla: Stankowski, Sean, et al. “Toward the Integration of Speciation Research.” Evolutionary
Journal of the Linnean Society, vol. 3, no. 1, kzae001, Oxford University
Press, 2024, doi:10.1093/evolinnean/kzae001.
short: S. Stankowski, A.D. Cutter, I. Satokangas, B.A. Lerch, J. Rolland, C.M. Smadja,
J.C. Segami Marzal, C.R. Cooney, P.G.D. Feulner, F.M.C.B. Domingos, H.L. North,
R. Yamaguchi, R.K. Butlin, J.B.W. Wolf, J. Coughlan, P. Heidbreder, R. Hernández-Gutiérrez,
K.B. Barnard-Kubow, D. Peede, L. Rancilhac, R.B. Salvador, K.A. Thompson, E.A.
Stacy, L.C. Moyle, M.D. Garlovsky, A. Maulana, A. Kantelinen, N.I. Cacho, H. Schneemann,
M. Domínguez, E.B. Dopman, K. Lohse, S.J. Rometsch, A.A. Comeault, R.M. Merrill,
E.S.C. Scordato, S. Singhal, V. Pärssinen, A.C.R. Lackey, S. Kumar, J.I. Meier,
N.H. Barton, C. Fraisse, M. Ravinet, J. Kulmuni, Evolutionary Journal of the Linnean
Society 3 (2024).
corr_author: '1'
date_created: 2025-01-29T10:38:17Z
date_published: 2024-02-16T00:00:00Z
date_updated: 2025-01-29T10:55:54Z
day: '16'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1093/evolinnean/kzae001
file:
- access_level: open_access
checksum: db08120a92527acaef476bd93f2b87f9
content_type: application/pdf
creator: dernst
date_created: 2025-01-29T10:52:40Z
date_updated: 2025-01-29T10:52:40Z
file_id: '18950'
file_name: 2024_EvolJourLinneanSoc_Stankowski.pdf
file_size: 3935454
relation: main_file
success: 1
file_date_updated: 2025-01-29T10:52:40Z
has_accepted_license: '1'
intvolume: ' 3'
issue: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: Evolutionary Journal of the Linnean Society
publication_identifier:
issn:
- 2752-938X
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Toward the integration of speciation research
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '19520'
abstract:
- lang: eng
text: Vertebrates exhibit a wide range of motor behaviors, ranging from swimming
to complex limb-based movements. Here we take advantage of frog metamorphosis,
which captures a swim-to-limb-based movement transformation during the development
of a single organism, to explore changes in the underlying spinal circuits. We
find that the tadpole spinal cord contains small and largely homogeneous populations
of motor neurons (MNs) and V1 interneurons (V1s) at early escape swimming stages.
These neuronal populations only modestly increase in number and subtype heterogeneity
with the emergence of free swimming. In contrast, during frog metamorphosis and
the emergence of limb movement, there is a dramatic expansion of MN and V1 interneuron
number and transcriptional heterogeneity, culminating in cohorts of neurons that
exhibit striking molecular similarity to mammalian motor circuits. CRISPR/Cas9-mediated
gene disruption of the limb MN and V1 determinants FoxP1 and Engrailed-1, respectively,
results in severe but selective deficits in tail and limb function. Our work thus
demonstrates that neural diversity scales exponentially with increasing behavioral
complexity and illustrates striking evolutionary conservation in the molecular
organization and function of motor circuits across species.
acknowledged_ssus:
- _id: Bio
acknowledgement: "We would like to thank the members of the Sweeney Lab (especially
Stavros Papadopoulos and\r\nSophie Gobeil) for their contributions to this project
and, in addition to the lab, Graziana Gatto\r\nand Mario de Bono, for discussion,
and support. We are also grateful to Tom Jessell and Chris\r\nKintner for their
scientific insight and mentorship during the conception of this project. This\r\nproject
would also not have been possible with the technical support of the Matthias Nowak,\r\nVerena
Mayer and the Aquatics as well as the Imaging and Optics Facility support teams\r\n(ISTA).
In addition, we thank our funding sources for providing the resources to do these\r\nexperiments:
FTI Strategy Lower Austria Dissertation Grant Number FT121-D-046 (D.V.);\r\nHorizon
Europe ERC Starting Grant Number 101041551 (L.B.S., F.A.T. and D.V); Special\r\nResearch
Program (SFB) of the Austrian Science Fund (FWF) Project number F7814-B (L.B.S);\r\nNINDS
5R35NS116858 (J.S.D); CZI grant DAF2020-225401 (DOI): 10.37921/120055ratwvi\r\n(R.H.);
NIH grant number R01NS123116 (J.B.B); American Lebanese Syrian Associated\r\nCharities
(ALSAC) (J.B.B.); German Academic Exchange Service (DAAD) IFI Grant Number\r\n57515251-91853472
(Z.H.); and Project A.L.S. (S.B-M.). "
article_processing_charge: No
author:
- first_name: David
full_name: Vijatovic, David
id: cf391e77-ec3c-11ea-a124-d69323410b58
last_name: Vijatovic
- first_name: 'Florina Alexandra '
full_name: 'Toma, Florina Alexandra '
id: 2f73f876-f128-11eb-9611-b96b5a30cb0e
last_name: Toma
- first_name: Zoe P
full_name: Harrington, Zoe P
id: a8144562-32c9-11ee-b5ce-d9800628bda2
last_name: Harrington
orcid: 0009-0008-0158-4032
- first_name: Christoph M
full_name: Sommer, Christoph M
id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
last_name: Sommer
orcid: 0000-0003-1216-9105
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Alexandra J.
full_name: Trevisan, Alexandra J.
last_name: Trevisan
- first_name: Phillip
full_name: Chapman, Phillip
last_name: Chapman
- first_name: Mara
full_name: Julseth, Mara
id: 1cf464b2-dc7d-11ea-9b2f-f9b1aa9417d1
last_name: Julseth
- first_name: Susan
full_name: Brenner-Morton, Susan
last_name: Brenner-Morton
- first_name: Mariano I.
full_name: Gabitto, Mariano I.
last_name: Gabitto
- first_name: Jeremy S.
full_name: Dasen, Jeremy S.
last_name: Dasen
- first_name: Jay B.
full_name: Bikoff, Jay B.
last_name: Bikoff
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
citation:
ama: Vijatovic D, Toma FA, Harrington ZP, et al. Spinal neuron diversity scales
exponentially with swim-to-limb transformation during frog metamorphosis. bioRxiv.
doi:10.1101/2024.09.20.614050
apa: Vijatovic, D., Toma, F. A., Harrington, Z. P., Sommer, C. M., Hauschild, R.,
Trevisan, A. J., … Sweeney, L. B. (n.d.). Spinal neuron diversity scales exponentially
with swim-to-limb transformation during frog metamorphosis. bioRxiv. https://doi.org/10.1101/2024.09.20.614050
chicago: Vijatovic, David, Florina Alexandra Toma, Zoe P Harrington, Christoph
M Sommer, Robert Hauschild, Alexandra J. Trevisan, Phillip Chapman, et al. “Spinal
Neuron Diversity Scales Exponentially with Swim-to-Limb Transformation during
Frog Metamorphosis.” BioRxiv, n.d. https://doi.org/10.1101/2024.09.20.614050.
ieee: D. Vijatovic et al., “Spinal neuron diversity scales exponentially
with swim-to-limb transformation during frog metamorphosis,” bioRxiv. .
ista: Vijatovic D, Toma FA, Harrington ZP, Sommer CM, Hauschild R, Trevisan AJ,
Chapman P, Julseth M, Brenner-Morton S, Gabitto MI, Dasen JS, Bikoff JB, Sweeney
LB. Spinal neuron diversity scales exponentially with swim-to-limb transformation
during frog metamorphosis. bioRxiv, 10.1101/2024.09.20.614050.
mla: Vijatovic, David, et al. “Spinal Neuron Diversity Scales Exponentially with
Swim-to-Limb Transformation during Frog Metamorphosis.” BioRxiv, doi:10.1101/2024.09.20.614050.
short: D. Vijatovic, F.A. Toma, Z.P. Harrington, C.M. Sommer, R. Hauschild, A.J.
Trevisan, P. Chapman, M. Julseth, S. Brenner-Morton, M.I. Gabitto, J.S. Dasen,
J.B. Bikoff, L.B. Sweeney, BioRxiv (n.d.).
corr_author: '1'
date_created: 2025-04-07T08:48:28Z
date_published: 2024-09-27T00:00:00Z
date_updated: 2025-05-14T11:40:13Z
day: '27'
department:
- _id: LoSw
- _id: TiVo
- _id: Bio
- _id: NiBa
doi: 10.1101/2024.09.20.614050
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2024.09.20.614050
month: '09'
oa: 1
oa_version: Preprint
project:
- _id: bd73af52-d553-11ed-ba76-912049f0ac7a
grant_number: FTI21-D-046
name: Development of V1 interneuron diversity during swim-to-walk transition of
Xenopus metamorphosis
- _id: ebb66355-77a9-11ec-83b8-b8ac210a4dae
grant_number: '101041551'
name: Development and Evolution of Tetrapod Motor Circuits
- _id: c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473
grant_number: CZI01
name: Tools for automation and feedback microscopy
publication: bioRxiv
publication_status: submitted
status: public
title: Spinal neuron diversity scales exponentially with swim-to-limb transformation
during frog metamorphosis
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2024'
...