[{"year":"2020","scopus_import":"1","abstract":[{"text":"Cell migration entails networks and bundles of actin filaments termed lamellipodia and microspikes or filopodia, respectively, as well as focal adhesions, all of which recruit Ena/VASP family members hitherto thought to antagonize efficient cell motility. However, we find these proteins to act as positive regulators of migration in different murine cell lines. CRISPR/Cas9-mediated loss of Ena/VASP proteins reduced lamellipodial actin assembly and perturbed lamellipodial architecture, as evidenced by changed network geometry as well as reduction of filament length and number that was accompanied by abnormal Arp2/3 complex and heterodimeric capping protein accumulation. Loss of Ena/VASP function also abolished the formation of microspikes normally embedded in lamellipodia, but not of filopodia capable of emanating without lamellipodia. Ena/VASP-deficiency also impaired integrin-mediated adhesion accompanied by reduced traction forces exerted through these structures. Our data thus uncover novel Ena/VASP functions of these actin polymerases that are fully consistent with their promotion of cell migration.","lang":"eng"}],"publication_status":"published","status":"public","date_published":"2020-05-11T00:00:00Z","pmid":1,"publisher":"eLife Sciences Publications","author":[{"last_name":"Damiano-Guercio","first_name":"Julia","full_name":"Damiano-Guercio, Julia"},{"full_name":"Kurzawa, Laëtitia","first_name":"Laëtitia","last_name":"Kurzawa"},{"last_name":"Müller","first_name":"Jan","full_name":"Müller, Jan","id":"AD07FDB4-0F61-11EA-8158-C4CC64CEAA8D"},{"last_name":"Dimchev","id":"38C393BE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8370-6161","full_name":"Dimchev, Georgi A","first_name":"Georgi A"},{"last_name":"Schaks","first_name":"Matthias","full_name":"Schaks, Matthias"},{"last_name":"Nemethova","id":"34E27F1C-F248-11E8-B48F-1D18A9856A87","first_name":"Maria","full_name":"Nemethova, Maria"},{"full_name":"Pokrant, Thomas","first_name":"Thomas","last_name":"Pokrant"},{"last_name":"Brühmann","first_name":"Stefan","full_name":"Brühmann, Stefan"},{"last_name":"Linkner","full_name":"Linkner, Joern","first_name":"Joern"},{"first_name":"Laurent","full_name":"Blanchoin, Laurent","last_name":"Blanchoin"},{"last_name":"Sixt","orcid":"0000-0002-6620-9179","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","first_name":"Michael K","full_name":"Sixt, Michael K"},{"last_name":"Rottner","first_name":"Klemens","full_name":"Rottner, Klemens"},{"last_name":"Faix","full_name":"Faix, Jan","first_name":"Jan"}],"day":"11","article_processing_charge":"No","file":[{"relation":"main_file","creator":"dernst","file_name":"2020_eLife_Damiano_Guercio.pdf","date_created":"2020-06-02T10:35:37Z","date_updated":"2020-07-14T12:48:05Z","content_type":"application/pdf","access_level":"open_access","checksum":"d33bd4441b9a0195718ce1ba5d2c48a6","file_id":"7914","file_size":10535713}],"oa_version":"Published Version","title":"Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion","doi":"10.7554/eLife.55351","external_id":{"pmid":["32391788"],"isi":["000537208000001"]},"project":[{"grant_number":"724373","_id":"25FE9508-B435-11E9-9278-68D0E5697425","name":"Cellular Navigation Along Spatial Gradients","call_identifier":"H2020"}],"ec_funded":1,"file_date_updated":"2020-07-14T12:48:05Z","date_updated":"2026-04-02T14:32:12Z","quality_controlled":"1","date_created":"2020-05-31T22:00:49Z","type":"journal_article","citation":{"apa":"Damiano-Guercio, J., Kurzawa, L., Müller, J., Dimchev, G. A., Schaks, M., Nemethova, M., … Faix, J. (2020). Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.55351\">https://doi.org/10.7554/eLife.55351</a>","chicago":"Damiano-Guercio, Julia, Laëtitia Kurzawa, Jan Müller, Georgi A Dimchev, Matthias Schaks, Maria Nemethova, Thomas Pokrant, et al. “Loss of Ena/VASP Interferes with Lamellipodium Architecture, Motility and Integrin-Dependent Adhesion.” <i>ELife</i>. eLife Sciences Publications, 2020. <a href=\"https://doi.org/10.7554/eLife.55351\">https://doi.org/10.7554/eLife.55351</a>.","mla":"Damiano-Guercio, Julia, et al. “Loss of Ena/VASP Interferes with Lamellipodium Architecture, Motility and Integrin-Dependent Adhesion.” <i>ELife</i>, vol. 9, e55351, eLife Sciences Publications, 2020, doi:<a href=\"https://doi.org/10.7554/eLife.55351\">10.7554/eLife.55351</a>.","short":"J. Damiano-Guercio, L. Kurzawa, J. Müller, G.A. Dimchev, M. Schaks, M. Nemethova, T. Pokrant, S. Brühmann, J. Linkner, L. Blanchoin, M.K. Sixt, K. Rottner, J. Faix, ELife 9 (2020).","ama":"Damiano-Guercio J, Kurzawa L, Müller J, et al. Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion. <i>eLife</i>. 2020;9. doi:<a href=\"https://doi.org/10.7554/eLife.55351\">10.7554/eLife.55351</a>","ista":"Damiano-Guercio J, Kurzawa L, Müller J, Dimchev GA, Schaks M, Nemethova M, Pokrant T, Brühmann S, Linkner J, Blanchoin L, Sixt MK, Rottner K, Faix J. 2020. Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion. eLife. 9, e55351.","ieee":"J. Damiano-Guercio <i>et al.</i>, “Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion,” <i>eLife</i>, vol. 9. eLife Sciences Publications, 2020."},"publication":"eLife","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","article_type":"original","volume":9,"oa":1,"has_accepted_license":"1","_id":"7909","department":[{"_id":"MiSi"}],"isi":1,"publication_identifier":{"eissn":["2050-084X"]},"month":"05","ddc":["570"],"intvolume":"         9","article_number":"e55351","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"language":[{"iso":"eng"}]},{"language":[{"iso":"eng"}],"article_number":"eabc4209","ddc":["572"],"intvolume":"       370","month":"10","publication_identifier":{"eissn":["1095-9203"]},"_id":"8737","department":[{"_id":"LeSa"}],"isi":1,"has_accepted_license":"1","volume":370,"oa":1,"article_type":"original","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publication":"Science","type":"journal_article","citation":{"mla":"Kampjut, Domen, and Leonid A. Sazanov. “The Coupling Mechanism of Mammalian Respiratory Complex I.” <i>Science</i>, vol. 370, no. 6516, eabc4209, American Association for the Advancement of Science, 2020, doi:<a href=\"https://doi.org/10.1126/science.abc4209\">10.1126/science.abc4209</a>.","chicago":"Kampjut, Domen, and Leonid A Sazanov. “The Coupling Mechanism of Mammalian Respiratory Complex I.” <i>Science</i>. American Association for the Advancement of Science, 2020. <a href=\"https://doi.org/10.1126/science.abc4209\">https://doi.org/10.1126/science.abc4209</a>.","apa":"Kampjut, D., &#38; Sazanov, L. A. (2020). The coupling mechanism of mammalian respiratory complex I. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.abc4209\">https://doi.org/10.1126/science.abc4209</a>","ieee":"D. Kampjut and L. A. Sazanov, “The coupling mechanism of mammalian respiratory complex I,” <i>Science</i>, vol. 370, no. 6516. American Association for the Advancement of Science, 2020.","ista":"Kampjut D, Sazanov LA. 2020. The coupling mechanism of mammalian respiratory complex I. Science. 370(6516), eabc4209.","short":"D. Kampjut, L.A. Sazanov, Science 370 (2020).","ama":"Kampjut D, Sazanov LA. The coupling mechanism of mammalian respiratory complex I. <i>Science</i>. 2020;370(6516). doi:<a href=\"https://doi.org/10.1126/science.abc4209\">10.1126/science.abc4209</a>"},"date_created":"2020-11-08T23:01:23Z","file_date_updated":"2020-11-26T18:47:58Z","date_updated":"2026-04-02T14:32:34Z","quality_controlled":"1","ec_funded":1,"issue":"6516","project":[{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"International IST Doctoral Program","grant_number":"665385"}],"external_id":{"isi":["000583031800004"],"pmid":["32972993"]},"title":"The coupling mechanism of mammalian respiratory complex I","doi":"10.1126/science.abc4209","oa_version":"Submitted Version","acknowledgement":"We thank J. Novacek (CEITEC Brno) and V.-V. Hodirnau (IST Austria) for their help with collecting cryo-EM datasets. We thank the IST Life Science and Electron Microscopy Facilities for providing equipment. This work has been supported by iNEXT,project number 653706, funded by the Horizon 2020 program of the European Union. This article reflects only the authors’view,and the European Commission is not responsible for any use that may be made of the information it contains. CIISB research infrastructure project LM2015043 funded by MEYS CR is gratefully acknowledged for the financial support of the measurements at the CF Cryo-electron Microscopy and Tomography CEITEC MU.This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement no. 665385","file":[{"file_name":"Full_manuscript_with_SI_opt_red.pdf","creator":"lsazanov","relation":"main_file","file_id":"8820","file_size":7618987,"access_level":"open_access","checksum":"658ba90979ca9528a2efdfac8547047a","success":1,"date_updated":"2020-11-26T18:47:58Z","content_type":"application/pdf","date_created":"2020-11-26T18:47:58Z"}],"day":"30","acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"EM-Fac"}],"article_processing_charge":"No","publisher":"American Association for the Advancement of Science","author":[{"first_name":"Domen","full_name":"Kampjut, Domen","orcid":"0000-0002-6018-3422","id":"37233050-F248-11E8-B48F-1D18A9856A87","last_name":"Kampjut"},{"last_name":"Sazanov","first_name":"Leonid A","full_name":"Sazanov, Leonid A","orcid":"0000-0002-0977-7989","id":"338D39FE-F248-11E8-B48F-1D18A9856A87"}],"pmid":1,"date_published":"2020-10-30T00:00:00Z","status":"public","abstract":[{"text":"Mitochondrial complex I couples NADH:ubiquinone oxidoreduction to proton pumping by an unknown mechanism. Here, we present cryo-electron microscopy structures of ovine complex I in five different conditions, including turnover, at resolutions up to 2.3 to 2.5 angstroms. Resolved water molecules allowed us to experimentally define the proton translocation pathways. Quinone binds at three positions along the quinone cavity, as does the inhibitor rotenone that also binds within subunit ND4. Dramatic conformational changes around the quinone cavity couple the redox reaction to proton translocation during open-to-closed state transitions of the enzyme. In the induced deactive state, the open conformation is arrested by the ND6 subunit. We propose a detailed molecular coupling mechanism of complex I, which is an unexpected combination of conformational changes and electrostatic interactions.","lang":"eng"}],"publication_status":"published","year":"2020","scopus_import":"1"},{"publication_identifier":{"eissn":["1742-5468"]},"_id":"7638","isi":1,"department":[{"_id":"MaSe"}],"has_accepted_license":"1","language":[{"iso":"eng"}],"article_number":"013106","ddc":["530"],"intvolume":"      2020","month":"01","publication":"Journal of Statistical Mechanics: Theory and Experiment","citation":{"short":"S. De Nicola, B. Doyon, M.J. Bhaseen, Journal of Statistical Mechanics: Theory and Experiment 2020 (2020).","ama":"De Nicola S, Doyon B, Bhaseen MJ. Non-equilibrium quantum spin dynamics from classical stochastic processes. <i>Journal of Statistical Mechanics: Theory and Experiment</i>. 2020;2020(1). doi:<a href=\"https://doi.org/10.1088/1742-5468/ab6093\">10.1088/1742-5468/ab6093</a>","ista":"De Nicola S, Doyon B, Bhaseen MJ. 2020. Non-equilibrium quantum spin dynamics from classical stochastic processes. Journal of Statistical Mechanics: Theory and Experiment. 2020(1), 013106.","ieee":"S. De Nicola, B. Doyon, and M. J. Bhaseen, “Non-equilibrium quantum spin dynamics from classical stochastic processes,” <i>Journal of Statistical Mechanics: Theory and Experiment</i>, vol. 2020, no. 1. IOP Publishing, 2020.","apa":"De Nicola, S., Doyon, B., &#38; Bhaseen, M. J. (2020). Non-equilibrium quantum spin dynamics from classical stochastic processes. <i>Journal of Statistical Mechanics: Theory and Experiment</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/1742-5468/ab6093\">https://doi.org/10.1088/1742-5468/ab6093</a>","chicago":"De Nicola, Stefano, B. Doyon, and M. J. Bhaseen. “Non-Equilibrium Quantum Spin Dynamics from Classical Stochastic Processes.” <i>Journal of Statistical Mechanics: Theory and Experiment</i>. IOP Publishing, 2020. <a href=\"https://doi.org/10.1088/1742-5468/ab6093\">https://doi.org/10.1088/1742-5468/ab6093</a>.","mla":"De Nicola, Stefano, et al. “Non-Equilibrium Quantum Spin Dynamics from Classical Stochastic Processes.” <i>Journal of Statistical Mechanics: Theory and Experiment</i>, vol. 2020, no. 1, 013106, IOP Publishing, 2020, doi:<a href=\"https://doi.org/10.1088/1742-5468/ab6093\">10.1088/1742-5468/ab6093</a>."},"type":"journal_article","date_created":"2020-04-05T22:00:50Z","file_date_updated":"2020-07-14T12:48:01Z","date_updated":"2026-04-02T14:33:33Z","quality_controlled":"1","volume":2020,"oa":1,"article_type":"original","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","title":"Non-equilibrium quantum spin dynamics from classical stochastic processes","doi":"10.1088/1742-5468/ab6093","oa_version":"Published Version","ec_funded":1,"issue":"1","project":[{"grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships"},{"name":"IST Austria Open Access Fund","_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854"}],"external_id":{"arxiv":["1909.13142"],"isi":["000520187500001"]},"corr_author":"1","status":"public","abstract":[{"lang":"eng","text":"Following on from our recent work, we investigate a stochastic approach to non-equilibrium quantum spin systems. We show how the method can be applied to a variety of physical observables and for different initial conditions. We provide exact formulae of broad applicability for the time-dependence of expectation values and correlation functions following a quantum quench in terms of averages over classical stochastic processes. We further explore the behavior of the classical stochastic variables in the presence of dynamical quantum phase transitions, including results for their distributions and correlation functions. We provide details on the numerical solution of the associated stochastic differential equations, and examine the growth of fluctuations in the classical description. We discuss the strengths and limitations of the current implementation of the stochastic approach and the potential for further development."}],"publication_status":"published","year":"2020","scopus_import":"1","file":[{"relation":"main_file","creator":"dernst","file_name":"2020_JournStatisticalMech_DeNicola.pdf","date_created":"2020-04-06T13:15:49Z","date_updated":"2020-07-14T12:48:01Z","content_type":"application/pdf","checksum":"4030e683c15d30b7b4794ec7dc1b6537","access_level":"open_access","file_size":3159026,"file_id":"7648"}],"day":"22","article_processing_charge":"No","arxiv":1,"author":[{"first_name":"Stefano","full_name":"De Nicola, Stefano","orcid":"0000-0002-4842-6671","id":"42832B76-F248-11E8-B48F-1D18A9856A87","last_name":"De Nicola"},{"last_name":"Doyon","first_name":"B.","full_name":"Doyon, B."},{"first_name":"M. J.","full_name":"Bhaseen, M. J.","last_name":"Bhaseen"}],"publisher":"IOP Publishing","date_published":"2020-01-22T00:00:00Z"},{"month":"10","ddc":["570"],"intvolume":"        11","article_number":"5037","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"language":[{"iso":"eng"}],"has_accepted_license":"1","isi":1,"_id":"8669","department":[{"_id":"EdHa"}],"publication_identifier":{"eissn":["2041-1723"]},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","article_type":"original","volume":11,"oa":1,"file_date_updated":"2020-10-19T11:27:46Z","quality_controlled":"1","date_updated":"2026-04-02T14:29:58Z","date_created":"2020-10-18T22:01:35Z","type":"journal_article","publication":"Nature Communications","citation":{"ista":"Sznurkowska MK, Hannezo EB, Azzarelli R, Chatzeli L, Ikeda T, Yoshida S, Philpott A, Simons BD. 2020. Tracing the cellular basis of islet specification in mouse pancreas. Nature Communications. 11, 5037.","short":"M.K. Sznurkowska, E.B. Hannezo, R. Azzarelli, L. Chatzeli, T. Ikeda, S. Yoshida, A. Philpott, B.D. Simons, Nature Communications 11 (2020).","ama":"Sznurkowska MK, Hannezo EB, Azzarelli R, et al. Tracing the cellular basis of islet specification in mouse pancreas. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-18837-3\">10.1038/s41467-020-18837-3</a>","ieee":"M. K. Sznurkowska <i>et al.</i>, “Tracing the cellular basis of islet specification in mouse pancreas,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","chicago":"Sznurkowska, Magdalena K., Edouard B Hannezo, Roberta Azzarelli, Lemonia Chatzeli, Tatsuro Ikeda, Shosei Yoshida, Anna Philpott, and Benjamin D Simons. “Tracing the Cellular Basis of Islet Specification in Mouse Pancreas.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-18837-3\">https://doi.org/10.1038/s41467-020-18837-3</a>.","apa":"Sznurkowska, M. K., Hannezo, E. B., Azzarelli, R., Chatzeli, L., Ikeda, T., Yoshida, S., … Simons, B. D. (2020). Tracing the cellular basis of islet specification in mouse pancreas. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-18837-3\">https://doi.org/10.1038/s41467-020-18837-3</a>","mla":"Sznurkowska, Magdalena K., et al. “Tracing the Cellular Basis of Islet Specification in Mouse Pancreas.” <i>Nature Communications</i>, vol. 11, 5037, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-18837-3\">10.1038/s41467-020-18837-3</a>."},"external_id":{"pmid":["33028844"],"isi":["000577244600003"]},"oa_version":"Published Version","title":"Tracing the cellular basis of islet specification in mouse pancreas","doi":"10.1038/s41467-020-18837-3","date_published":"2020-10-07T00:00:00Z","pmid":1,"author":[{"full_name":"Sznurkowska, Magdalena K.","first_name":"Magdalena K.","last_name":"Sznurkowska"},{"last_name":"Hannezo","first_name":"Edouard B","full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Azzarelli","full_name":"Azzarelli, Roberta","first_name":"Roberta"},{"full_name":"Chatzeli, Lemonia","first_name":"Lemonia","last_name":"Chatzeli"},{"last_name":"Ikeda","first_name":"Tatsuro","full_name":"Ikeda, Tatsuro"},{"last_name":"Yoshida","first_name":"Shosei","full_name":"Yoshida, Shosei"},{"full_name":"Philpott, Anna","first_name":"Anna","last_name":"Philpott"},{"last_name":"Simons","full_name":"Simons, Benjamin D","first_name":"Benjamin D"}],"publisher":"Springer Nature","day":"07","article_processing_charge":"No","file":[{"file_name":"2020_NatureComm_Sznurkowska.pdf","relation":"main_file","creator":"dernst","checksum":"0ecc0eab72d2d50694852579611a6624","success":1,"access_level":"open_access","file_size":5540540,"file_id":"8677","date_created":"2020-10-19T11:27:46Z","date_updated":"2020-10-19T11:27:46Z","content_type":"application/pdf"}],"year":"2020","scopus_import":"1","abstract":[{"text":"Pancreatic islets play an essential role in regulating blood glucose level. Although the molecular pathways underlying islet cell differentiation are beginning to be resolved, the cellular basis of islet morphogenesis and fate allocation remain unclear. By combining unbiased and targeted lineage tracing, we address the events leading to islet formation in the mouse. From the statistical analysis of clones induced at multiple embryonic timepoints, here we show that, during the secondary transition, islet formation involves the aggregation of multiple equipotent endocrine progenitors that transition from a phase of stochastic amplification by cell division into a phase of sublineage restriction and limited islet fission. Together, these results explain quantitatively the heterogeneous size distribution and degree of polyclonality of maturing islets, as well as dispersion of progenitors within and between islets. Further, our results show that, during the secondary transition, α- and β-cells are generated in a contemporary manner. Together, these findings provide insight into the cellular basis of islet development.","lang":"eng"}],"publication_status":"published","status":"public"},{"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"volume":33,"article_type":"original","date_created":"2020-10-25T23:01:16Z","quality_controlled":"1","date_updated":"2026-04-02T14:31:34Z","file_date_updated":"2020-10-27T12:09:57Z","type":"journal_article","citation":{"ama":"Fischer JL, Kniely M. Variance reduction for effective energies of random lattices in the Thomas-Fermi-von Weizsäcker model. <i>Nonlinearity</i>. 2020;33(11):5733-5772. doi:<a href=\"https://doi.org/10.1088/1361-6544/ab9728\">10.1088/1361-6544/ab9728</a>","short":"J.L. Fischer, M. Kniely, Nonlinearity 33 (2020) 5733–5772.","ista":"Fischer JL, Kniely M. 2020. Variance reduction for effective energies of random lattices in the Thomas-Fermi-von Weizsäcker model. Nonlinearity. 33(11), 5733–5772.","ieee":"J. L. Fischer and M. Kniely, “Variance reduction for effective energies of random lattices in the Thomas-Fermi-von Weizsäcker model,” <i>Nonlinearity</i>, vol. 33, no. 11. IOP Publishing, pp. 5733–5772, 2020.","apa":"Fischer, J. L., &#38; Kniely, M. (2020). Variance reduction for effective energies of random lattices in the Thomas-Fermi-von Weizsäcker model. <i>Nonlinearity</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/1361-6544/ab9728\">https://doi.org/10.1088/1361-6544/ab9728</a>","chicago":"Fischer, Julian L, and Michael Kniely. “Variance Reduction for Effective Energies of Random Lattices in the Thomas-Fermi-von Weizsäcker Model.” <i>Nonlinearity</i>. IOP Publishing, 2020. <a href=\"https://doi.org/10.1088/1361-6544/ab9728\">https://doi.org/10.1088/1361-6544/ab9728</a>.","mla":"Fischer, Julian L., and Michael Kniely. “Variance Reduction for Effective Energies of Random Lattices in the Thomas-Fermi-von Weizsäcker Model.” <i>Nonlinearity</i>, vol. 33, no. 11, IOP Publishing, 2020, pp. 5733–72, doi:<a href=\"https://doi.org/10.1088/1361-6544/ab9728\">10.1088/1361-6544/ab9728</a>."},"publication":"Nonlinearity","intvolume":"        33","ddc":["510"],"month":"11","language":[{"iso":"eng"}],"tmp":{"name":"Creative Commons Attribution 3.0 Unported (CC BY 3.0)","image":"/images/cc_by.png","short":"CC BY (3.0)","legal_code_url":"https://creativecommons.org/licenses/by/3.0/legalcode"},"_id":"8697","department":[{"_id":"JuFi"}],"isi":1,"license":"https://creativecommons.org/licenses/by/3.0/","has_accepted_license":"1","page":"5733-5772","publication_identifier":{"issn":["0951-7715"],"eissn":["1361-6544"]},"publisher":"IOP Publishing","author":[{"orcid":"0000-0002-0479-558X","id":"2C12A0B0-F248-11E8-B48F-1D18A9856A87","first_name":"Julian L","full_name":"Fischer, Julian L","last_name":"Fischer"},{"last_name":"Kniely","first_name":"Michael","full_name":"Kniely, Michael","orcid":"0000-0001-5645-4333","id":"2CA2C08C-F248-11E8-B48F-1D18A9856A87"}],"arxiv":1,"date_published":"2020-11-01T00:00:00Z","file":[{"relation":"main_file","creator":"cziletti","file_name":"2020_Nonlinearity_Fischer.pdf","date_created":"2020-10-27T12:09:57Z","content_type":"application/pdf","date_updated":"2020-10-27T12:09:57Z","checksum":"ed90bc6eb5f32ee6157fef7f3aabc057","success":1,"access_level":"open_access","file_size":1223899,"file_id":"8710"}],"article_processing_charge":"Yes (via OA deal)","day":"01","publication_status":"published","abstract":[{"text":"In the computation of the material properties of random alloys, the method of 'special quasirandom structures' attempts to approximate the properties of the alloy on a finite volume with higher accuracy by replicating certain statistics of the random atomic lattice in the finite volume as accurately as possible. In the present work, we provide a rigorous justification for a variant of this method in the framework of the Thomas–Fermi–von Weizsäcker (TFW) model. Our approach is based on a recent analysis of a related variance reduction method in stochastic homogenization of linear elliptic PDEs and the locality properties of the TFW model. Concerning the latter, we extend an exponential locality result by Nazar and Ortner to include point charges, a result that may be of independent interest.","lang":"eng"}],"scopus_import":"1","year":"2020","status":"public","corr_author":"1","external_id":{"arxiv":["1906.12245"],"isi":["000576492700001"]},"issue":"11","oa_version":"Published Version","doi":"10.1088/1361-6544/ab9728","title":"Variance reduction for effective energies of random lattices in the Thomas-Fermi-von Weizsäcker model"},{"department":[{"_id":"BeBi"}],"_id":"9208","publication_identifier":{"eissn":["2523-3971"]},"intvolume":"         2","month":"09","language":[{"iso":"eng"}],"article_number":"1505","date_created":"2021-02-28T23:01:25Z","quality_controlled":"1","date_updated":"2026-04-02T14:31:49Z","citation":{"chicago":"Laccone, Francesco, Luigi Malomo, Jesus Perez Rodriguez, Nico Pietroni, Federico Ponchio, Bernd Bickel, and Paolo Cignoni. “A Bending-Active Twisted-Arch Plywood Structure: Computational Design and Fabrication of the FlexMaps Pavilion.” <i>SN Applied Sciences</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1007/s42452-020-03305-w\">https://doi.org/10.1007/s42452-020-03305-w</a>.","apa":"Laccone, F., Malomo, L., Perez Rodriguez, J., Pietroni, N., Ponchio, F., Bickel, B., &#38; Cignoni, P. (2020). A bending-active twisted-arch plywood structure: Computational design and fabrication of the FlexMaps Pavilion. <i>SN Applied Sciences</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s42452-020-03305-w\">https://doi.org/10.1007/s42452-020-03305-w</a>","mla":"Laccone, Francesco, et al. “A Bending-Active Twisted-Arch Plywood Structure: Computational Design and Fabrication of the FlexMaps Pavilion.” <i>SN Applied Sciences</i>, vol. 2, no. 9, 1505, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1007/s42452-020-03305-w\">10.1007/s42452-020-03305-w</a>.","ista":"Laccone F, Malomo L, Perez Rodriguez J, Pietroni N, Ponchio F, Bickel B, Cignoni P. 2020. A bending-active twisted-arch plywood structure: Computational design and fabrication of the FlexMaps Pavilion. SN Applied Sciences. 2(9), 1505.","ama":"Laccone F, Malomo L, Perez Rodriguez J, et al. A bending-active twisted-arch plywood structure: Computational design and fabrication of the FlexMaps Pavilion. <i>SN Applied Sciences</i>. 2020;2(9). doi:<a href=\"https://doi.org/10.1007/s42452-020-03305-w\">10.1007/s42452-020-03305-w</a>","short":"F. Laccone, L. Malomo, J. Perez Rodriguez, N. Pietroni, F. Ponchio, B. Bickel, P. Cignoni, SN Applied Sciences 2 (2020).","ieee":"F. Laccone <i>et al.</i>, “A bending-active twisted-arch plywood structure: Computational design and fabrication of the FlexMaps Pavilion,” <i>SN Applied Sciences</i>, vol. 2, no. 9. Springer Nature, 2020."},"type":"journal_article","publication":"SN Applied Sciences","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","volume":2,"article_type":"original","acknowledgement":"The FlexMaps Pavilion has been awarded First Prize at the “Competition and Exhibition of innovative lightweight structures” organized by the IASS Working Group 21 within the FORM and FORCE, joint international conference of IASS Symposium 2019 and Structural Membranes 2019 (Barcelona, 7-11 October 2019) with the following motivation: “for its structural innovation of bending-twisting system, connection constructability and exquisite craftmanship”[20]. The authors would like to acknowledge the Visual Computing Lab Staff of ISTI - CNR, in particular Thomas Alderighi, Marco Callieri, Paolo Pingi; Antonio Rizzo of IPCF - CNR; and the Administrative Staff of ISTI - CNR. This research was partially funded by the EU H2020 Programme EVOCATION: Advanced Visual and Geometric Computing for 3D Capture, Display, and Fabrication (grant no. 813170).","oa_version":"None","title":"A bending-active twisted-arch plywood structure: Computational design and fabrication of the FlexMaps Pavilion","doi":"10.1007/s42452-020-03305-w","issue":"9","publication_status":"published","abstract":[{"lang":"eng","text":"Bending-active structures are able to efficiently produce complex curved shapes from flat panels. The desired deformation of the panels derives from the proper selection of their elastic properties. Optimized panels, called FlexMaps, are designed such that, once they are bent and assembled, the resulting static equilibrium configuration matches a desired input 3D shape. The FlexMaps elastic properties are controlled by locally varying spiraling geometric mesostructures, which are optimized in size and shape to match specific bending requests, namely the global curvature of the target shape. The design pipeline starts from a quad mesh representing the input 3D shape, which defines the edge size and the total amount of spirals: every quad will embed one spiral. Then, an optimization algorithm tunes the geometry of the spirals by using a simplified pre-computed rod model. This rod model is derived from a non-linear regression algorithm which approximates the non-linear behavior of solid FEM spiral models subject to hundreds of load combinations. This innovative pipeline has been applied to the project of a lightweight plywood pavilion named FlexMaps Pavilion, which is a single-layer piecewise twisted arch that fits a bounding box of 3.90x3.96x3.25 meters. This case study serves to test the applicability of this methodology at the architectural scale. The structure is validated via FE analyses and the fabrication of the full scale prototype."}],"scopus_import":"1","year":"2020","status":"public","publisher":"Springer Nature","author":[{"full_name":"Laccone, Francesco","first_name":"Francesco","last_name":"Laccone"},{"last_name":"Malomo","first_name":"Luigi","full_name":"Malomo, Luigi"},{"last_name":"Perez Rodriguez","id":"2DC83906-F248-11E8-B48F-1D18A9856A87","first_name":"Jesus","full_name":"Perez Rodriguez, Jesus"},{"first_name":"Nico","full_name":"Pietroni, Nico","last_name":"Pietroni"},{"last_name":"Ponchio","first_name":"Federico","full_name":"Ponchio, Federico"},{"last_name":"Bickel","orcid":"0000-0001-6511-9385","id":"49876194-F248-11E8-B48F-1D18A9856A87","first_name":"Bernd","full_name":"Bickel, Bernd"},{"last_name":"Cignoni","full_name":"Cignoni, Paolo","first_name":"Paolo"}],"date_published":"2020-09-01T00:00:00Z","article_processing_charge":"No","day":"01"},{"volume":11,"oa":1,"article_type":"original","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publication":"Nature Communications","type":"journal_article","citation":{"mla":"Kubiasova, Karolina, et al. “Cytokinin Fluoroprobe Reveals Multiple Sites of Cytokinin Perception at Plasma Membrane and Endoplasmic Reticulum.” <i>Nature Communications</i>, vol. 11, 4285, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-17949-0\">10.1038/s41467-020-17949-0</a>.","chicago":"Kubiasova, Karolina, Juan C Montesinos López, Olga Šamajová, Jaroslav Nisler, Václav Mik, Hana Semerádová, Lucie Plíhalová, et al. “Cytokinin Fluoroprobe Reveals Multiple Sites of Cytokinin Perception at Plasma Membrane and Endoplasmic Reticulum.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-17949-0\">https://doi.org/10.1038/s41467-020-17949-0</a>.","apa":"Kubiasova, K., Montesinos López, J. C., Šamajová, O., Nisler, J., Mik, V., Semerádová, H., … Spíchal, L. (2020). Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic reticulum. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-17949-0\">https://doi.org/10.1038/s41467-020-17949-0</a>","ieee":"K. Kubiasova <i>et al.</i>, “Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic reticulum,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","ista":"Kubiasova K, Montesinos López JC, Šamajová O, Nisler J, Mik V, Semerádová H, Plíhalová L, Novák O, Marhavý P, Cavallari N, Zalabák D, Berka K, Doležal K, Galuszka P, Šamaj J, Strnad M, Benková E, Plíhal O, Spíchal L. 2020. Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic reticulum. Nature Communications. 11, 4285.","ama":"Kubiasova K, Montesinos López JC, Šamajová O, et al. Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic reticulum. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-17949-0\">10.1038/s41467-020-17949-0</a>","short":"K. Kubiasova, J.C. Montesinos López, O. Šamajová, J. Nisler, V. Mik, H. Semerádová, L. Plíhalová, O. Novák, P. Marhavý, N. Cavallari, D. Zalabák, K. Berka, K. Doležal, P. Galuszka, J. Šamaj, M. Strnad, E. Benková, O. Plíhal, L. Spíchal, Nature Communications 11 (2020)."},"date_created":"2020-09-06T22:01:12Z","file_date_updated":"2020-09-10T08:05:19Z","quality_controlled":"1","date_updated":"2026-04-02T14:35:13Z","language":[{"iso":"eng"}],"article_number":"4285","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"ddc":["580"],"intvolume":"        11","month":"08","publication_identifier":{"eissn":["2041-1723"]},"department":[{"_id":"EvBe"}],"_id":"8336","isi":1,"has_accepted_license":"1","file":[{"file_name":"2020_NatureComm_Kubiasova.pdf","relation":"main_file","creator":"dernst","checksum":"7494b7665b3d2bf2d8edb13e4f12b92d","success":1,"access_level":"open_access","file_size":3455704,"file_id":"8357","date_created":"2020-09-10T08:05:19Z","date_updated":"2020-09-10T08:05:19Z","content_type":"application/pdf"}],"day":"27","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"article_processing_charge":"No","author":[{"last_name":"Kubiasova","orcid":"0000-0001-5630-9419","id":"946011F4-3E71-11EA-860B-C7A73DDC885E","first_name":"Karolina","full_name":"Kubiasova, Karolina"},{"last_name":"Montesinos López","full_name":"Montesinos López, Juan C","first_name":"Juan C","id":"310A8E3E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9179-6099"},{"first_name":"Olga","full_name":"Šamajová, Olga","last_name":"Šamajová"},{"last_name":"Nisler","first_name":"Jaroslav","full_name":"Nisler, Jaroslav"},{"last_name":"Mik","first_name":"Václav","full_name":"Mik, Václav"},{"last_name":"Semeradova","first_name":"Hana","full_name":"Semeradova, Hana","id":"42FE702E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Lucie","full_name":"Plíhalová, Lucie","last_name":"Plíhalová"},{"last_name":"Novák","full_name":"Novák, Ondřej","first_name":"Ondřej"},{"id":"3F45B078-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5227-5741","full_name":"Marhavý, Peter","first_name":"Peter","last_name":"Marhavý"},{"full_name":"Cavallari, Nicola","first_name":"Nicola","id":"457160E6-F248-11E8-B48F-1D18A9856A87","last_name":"Cavallari"},{"last_name":"Zalabák","first_name":"David","full_name":"Zalabák, David"},{"last_name":"Berka","first_name":"Karel","full_name":"Berka, Karel"},{"last_name":"Doležal","full_name":"Doležal, Karel","first_name":"Karel"},{"first_name":"Petr","full_name":"Galuszka, Petr","last_name":"Galuszka"},{"last_name":"Šamaj","full_name":"Šamaj, Jozef","first_name":"Jozef"},{"first_name":"Miroslav","full_name":"Strnad, Miroslav","last_name":"Strnad"},{"first_name":"Eva","full_name":"Benková, Eva","orcid":"0000-0002-8510-9739","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","last_name":"Benková"},{"first_name":"Ondřej","full_name":"Plíhal, Ondřej","last_name":"Plíhal"},{"first_name":"Lukáš","full_name":"Spíchal, Lukáš","last_name":"Spíchal"}],"publisher":"Springer Nature","date_published":"2020-08-27T00:00:00Z","pmid":1,"corr_author":"1","status":"public","abstract":[{"text":"Plant hormone cytokinins are perceived by a subfamily of sensor histidine kinases (HKs), which via a two-component phosphorelay cascade activate transcriptional responses in the nucleus. Subcellular localization of the receptors proposed the endoplasmic reticulum (ER) membrane as a principal cytokinin perception site, while study of cytokinin transport pointed to the plasma membrane (PM)-mediated cytokinin signalling. Here, by detailed monitoring of subcellular localizations of the fluorescently labelled natural cytokinin probe and the receptor ARABIDOPSIS HISTIDINE KINASE 4 (CRE1/AHK4) fused to GFP reporter, we show that pools of the ER-located cytokinin receptors can enter the secretory pathway and reach the PM in cells of the root apical meristem, and the cell plate of dividing meristematic cells. Brefeldin A (BFA) experiments revealed vesicular recycling of the receptor and its accumulation in BFA compartments. We provide a revised view on cytokinin signalling and the possibility of multiple sites of perception at PM and ER.","lang":"eng"}],"publication_status":"published","year":"2020","scopus_import":"1","ec_funded":1,"project":[{"call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme","_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734"},{"_id":"261821BC-B435-11E9-9278-68D0E5697425","name":"Molecular mechanisms of the cytokinin regulated endomembrane trafficking to coordinate plant organogenesis","grant_number":"24746"},{"name":"Molecular mechanism of auxindriven formative divisions delineating lateral root organogenesis in plants","_id":"253E54C8-B435-11E9-9278-68D0E5697425","grant_number":"ALTF710-2016"}],"external_id":{"pmid":["32855390"],"isi":["000567931000002"]},"doi":"10.1038/s41467-020-17949-0","title":"Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic reticulum","oa_version":"Published Version","acknowledgement":"This paper is dedicated to deceased P. Galuszka for his support and contribution to the project. This research was supported by the Scientific Service Units (SSU) of IST-Austria through resources provided by the Bioimaging Facility (BIF), the Life Science Facility (LSF) and by Centre of the Region Haná (CRH), Palacký University. We thank Lucia Hlusková, Zuzana Pěkná and Martin Hönig for technical assistance, and Fernando Aniento, Rashed Abualia and Andrej Hurný for sharing material. The work was supported from ERDF project “Plants as a tool for sustainable global development” (No. CZ.02.1.01/0.0/0.0/16_019/0000827), from Czech Science Foundation via projects 16-04184S (O.P., K.K. and K.D.), 18-23972Y (D.Z., K.K.), 17-21122S (K.B.), Erasmus+ (K.K.), Endowment Fund of Palacký University (K.K.) and EMBO Long-Term Fellowship, ALTF number 710-2016 (J.C.M.); People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement no. [291734] (N.C.); DOC Fellowship of the Austrian Academy of Sciences at the Institute of Science and Technology, Austria (H.S.)."},{"type":"journal_article","publication":"Plants","citation":{"chicago":"Moturu, Taraka Ramji, Sansrity Sinha, Hymavathi Salava, Sravankumar Thula, Tomasz Nodzyński, Radka Svobodová Vařeková, Jiří Friml, and Sibu Simon. “Molecular Evolution and Diversification of Proteins Involved in MiRNA Maturation Pathway.” <i>Plants</i>. MDPI, 2020. <a href=\"https://doi.org/10.3390/plants9030299\">https://doi.org/10.3390/plants9030299</a>.","apa":"Moturu, T. R., Sinha, S., Salava, H., Thula, S., Nodzyński, T., Vařeková, R. S., … Simon, S. (2020). Molecular evolution and diversification of proteins involved in miRNA maturation pathway. <i>Plants</i>. MDPI. <a href=\"https://doi.org/10.3390/plants9030299\">https://doi.org/10.3390/plants9030299</a>","mla":"Moturu, Taraka Ramji, et al. “Molecular Evolution and Diversification of Proteins Involved in MiRNA Maturation Pathway.” <i>Plants</i>, vol. 9, no. 3, 299, MDPI, 2020, doi:<a href=\"https://doi.org/10.3390/plants9030299\">10.3390/plants9030299</a>.","ista":"Moturu TR, Sinha S, Salava H, Thula S, Nodzyński T, Vařeková RS, Friml J, Simon S. 2020. Molecular evolution and diversification of proteins involved in miRNA maturation pathway. Plants. 9(3), 299.","ama":"Moturu TR, Sinha S, Salava H, et al. Molecular evolution and diversification of proteins involved in miRNA maturation pathway. <i>Plants</i>. 2020;9(3). doi:<a href=\"https://doi.org/10.3390/plants9030299\">10.3390/plants9030299</a>","short":"T.R. Moturu, S. Sinha, H. Salava, S. Thula, T. Nodzyński, R.S. Vařeková, J. Friml, S. Simon, Plants 9 (2020).","ieee":"T. R. Moturu <i>et al.</i>, “Molecular evolution and diversification of proteins involved in miRNA maturation pathway,” <i>Plants</i>, vol. 9, no. 3. MDPI, 2020."},"file_date_updated":"2020-07-14T12:48:00Z","quality_controlled":"1","date_updated":"2026-04-02T14:35:47Z","date_created":"2020-03-15T23:00:52Z","article_type":"original","volume":9,"oa":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publication_identifier":{"eissn":["2223-7747"]},"has_accepted_license":"1","_id":"7582","isi":1,"department":[{"_id":"JiFr"}],"article_number":"299","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"language":[{"iso":"eng"}],"month":"03","ddc":["580"],"intvolume":"         9","corr_author":"1","status":"public","year":"2020","scopus_import":"1","abstract":[{"text":"Small RNAs (smRNA, 19–25 nucleotides long), which are transcribed by RNA polymerase II, regulate the expression of genes involved in a multitude of processes in eukaryotes. miRNA biogenesis and the proteins involved in the biogenesis pathway differ across plant and animal lineages. The major proteins constituting the biogenesis pathway, namely, the Dicers (DCL/DCR) and Argonautes (AGOs), have been extensively studied. However, the accessory proteins (DAWDLE (DDL), SERRATE (SE), and TOUGH (TGH)) of the pathway that differs across the two lineages remain largely uncharacterized. We present the first detailed report on the molecular evolution and divergence of these proteins across eukaryotes. Although DDL is present in eukaryotes and prokaryotes, SE and TGH appear to be specific to eukaryotes. The addition/deletion of specific domains and/or domain-specific sequence divergence in the three proteins points to the observed functional divergence of these proteins across the two lineages, which correlates with the differences in miRNA length across the two lineages. Our data enhance the current understanding of the structure–function relationship of these proteins and reveals previous unexplored crucial residues in the three proteins that can be used as a basis for further functional characterization. The data presented here on the number of miRNAs in crown eukaryotic lineages are consistent with the notion of the expansion of the number of miRNA-coding genes in animal and plant lineages correlating with organismal complexity. Whether this difference in functionally correlates with the diversification (or presence/absence) of the three proteins studied here or the miRNA signaling in the plant and animal lineages is unclear. Based on our results of the three proteins studied here and previously available data concerning the evolution of miRNA genes in the plant and animal lineages, we believe that miRNAs probably evolved once in the ancestor to crown eukaryotes and have diversified independently in the eukaryotes.","lang":"eng"}],"publication_status":"published","day":"01","article_processing_charge":"No","file":[{"creator":"dernst","relation":"main_file","file_name":"2020_Plants_Moturu.pdf","date_updated":"2020-07-14T12:48:00Z","content_type":"application/pdf","date_created":"2020-03-23T13:37:00Z","file_id":"7614","file_size":2373484,"access_level":"open_access","checksum":"6d5af3e17266a48996b4af4e67e88a85"}],"date_published":"2020-03-01T00:00:00Z","pmid":1,"author":[{"first_name":"Taraka Ramji","full_name":"Moturu, Taraka Ramji","last_name":"Moturu"},{"full_name":"Sinha, Sansrity","first_name":"Sansrity","last_name":"Sinha"},{"last_name":"Salava","full_name":"Salava, Hymavathi","first_name":"Hymavathi"},{"full_name":"Thula, Sravankumar","first_name":"Sravankumar","last_name":"Thula"},{"last_name":"Nodzyński","full_name":"Nodzyński, Tomasz","first_name":"Tomasz"},{"full_name":"Vařeková, Radka Svobodová","first_name":"Radka Svobodová","last_name":"Vařeková"},{"last_name":"Friml","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jiří","full_name":"Friml, Jiří"},{"last_name":"Simon","full_name":"Simon, Sibu","first_name":"Sibu","id":"4542EF9A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-1998-6741"}],"publisher":"MDPI","doi":"10.3390/plants9030299","title":"Molecular evolution and diversification of proteins involved in miRNA maturation pathway","oa_version":"Published Version","issue":"3","ec_funded":1,"external_id":{"isi":["000525315000035"],"pmid":["32121542"]},"project":[{"_id":"25716A02-B435-11E9-9278-68D0E5697425","name":"Polarity and subcellular dynamics in plants","call_identifier":"FP7","grant_number":"282300"}]},{"article_processing_charge":"No","day":"01","file":[{"creator":"dernst","relation":"main_file","file_name":"2020_TrendsNeuroscience_Parenti.pdf","content_type":"application/pdf","date_updated":"2020-11-25T09:43:40Z","date_created":"2020-11-25T09:43:40Z","file_id":"8805","file_size":1439550,"access_level":"open_access","checksum":"67db0251b1d415ae59005f876fcf9e34","success":1}],"pmid":1,"date_published":"2020-08-01T00:00:00Z","publisher":"Elsevier","author":[{"id":"D93538B0-5B71-11E9-AC62-02EBE5697425","full_name":"Parenti, Ilaria","first_name":"Ilaria","last_name":"Parenti"},{"first_name":"Luis E","full_name":"Garcia Rabaneda, Luis E","id":"33D1B084-F248-11E8-B48F-1D18A9856A87","last_name":"Garcia Rabaneda"},{"last_name":"Schön","id":"C8E17EDC-D7AA-11E9-B7B7-45ECE5697425","first_name":"Hanna","full_name":"Schön, Hanna"},{"id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","full_name":"Novarino, Gaia","first_name":"Gaia","last_name":"Novarino"}],"status":"public","corr_author":"1","scopus_import":"1","year":"2020","abstract":[{"text":"Neurodevelopmental disorders (NDDs) are a class of disorders affecting brain development and function and are characterized by wide genetic and clinical variability. In this review, we discuss the multiple factors that influence the clinical presentation of NDDs, with particular attention to gene vulnerability, mutational load, and the two-hit model. Despite the complex architecture of\r\nmutational events associated with NDDs, the various proteins involved appear to converge on common pathways, such as synaptic plasticity/function, chromatin remodelers and the mammalian target of rapamycin (mTOR) pathway. A thorough understanding of the mechanisms behind these pathways will hopefully lead to the identification of candidates that could be targeted for treatment approaches.","lang":"eng"}],"publication_status":"published","issue":"8","ec_funded":1,"external_id":{"isi":["000553090600008"],"pmid":["32507511"]},"project":[{"grant_number":"715508","_id":"25444568-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models"}],"doi":"10.1016/j.tins.2020.05.004","title":"Neurodevelopmental disorders: From genetics to functional pathways","acknowledgement":"We wish to thank Jasmin Morandell for generously sharing Figure 2. This work was supported by the European Research Council Starting Grant (grant 715508 ) to G.N.","oa_version":"Published Version","article_type":"original","oa":1,"volume":43,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","type":"journal_article","citation":{"ieee":"I. Parenti, L. E. Garcia Rabaneda, H. Schön, and G. Novarino, “Neurodevelopmental disorders: From genetics to functional pathways,” <i>Trends in Neurosciences</i>, vol. 43, no. 8. Elsevier, pp. 608–621, 2020.","ista":"Parenti I, Garcia Rabaneda LE, Schön H, Novarino G. 2020. Neurodevelopmental disorders: From genetics to functional pathways. Trends in Neurosciences. 43(8), 608–621.","short":"I. Parenti, L.E. Garcia Rabaneda, H. Schön, G. Novarino, Trends in Neurosciences 43 (2020) 608–621.","ama":"Parenti I, Garcia Rabaneda LE, Schön H, Novarino G. Neurodevelopmental disorders: From genetics to functional pathways. <i>Trends in Neurosciences</i>. 2020;43(8):608-621. doi:<a href=\"https://doi.org/10.1016/j.tins.2020.05.004\">10.1016/j.tins.2020.05.004</a>","mla":"Parenti, Ilaria, et al. “Neurodevelopmental Disorders: From Genetics to Functional Pathways.” <i>Trends in Neurosciences</i>, vol. 43, no. 8, Elsevier, 2020, pp. 608–21, doi:<a href=\"https://doi.org/10.1016/j.tins.2020.05.004\">10.1016/j.tins.2020.05.004</a>.","chicago":"Parenti, Ilaria, Luis E Garcia Rabaneda, Hanna Schön, and Gaia Novarino. “Neurodevelopmental Disorders: From Genetics to Functional Pathways.” <i>Trends in Neurosciences</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.tins.2020.05.004\">https://doi.org/10.1016/j.tins.2020.05.004</a>.","apa":"Parenti, I., Garcia Rabaneda, L. E., Schön, H., &#38; Novarino, G. (2020). Neurodevelopmental disorders: From genetics to functional pathways. <i>Trends in Neurosciences</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tins.2020.05.004\">https://doi.org/10.1016/j.tins.2020.05.004</a>"},"publication":"Trends in Neurosciences","date_updated":"2026-04-02T14:36:06Z","quality_controlled":"1","file_date_updated":"2020-11-25T09:43:40Z","date_created":"2020-06-14T22:00:49Z","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"language":[{"iso":"eng"}],"month":"08","intvolume":"        43","ddc":["570"],"publication_identifier":{"issn":["0166-2236"],"eissn":["1878-108X"]},"page":"608-621","has_accepted_license":"1","department":[{"_id":"GaNo"}],"_id":"7957","isi":1},{"article_type":"original","oa":1,"volume":11,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","related_material":{"link":[{"url":"https://ist.ac.at/en/news/mystery-of-giant-proton-pump-solved/","description":"News on IST Homepage","relation":"press_release"}]},"citation":{"ieee":"J. Gutierrez-Fernandez <i>et al.</i>, “Key role of quinone in the mechanism of respiratory complex I,” <i>Nature Communications</i>, vol. 11, no. 1. Springer Nature, 2020.","ista":"Gutierrez-Fernandez J, Kaszuba K, Minhas GS, Baradaran R, Tambalo M, Gallagher DT, Sazanov LA. 2020. Key role of quinone in the mechanism of respiratory complex I. Nature Communications. 11(1), 4135.","ama":"Gutierrez-Fernandez J, Kaszuba K, Minhas GS, et al. Key role of quinone in the mechanism of respiratory complex I. <i>Nature Communications</i>. 2020;11(1). doi:<a href=\"https://doi.org/10.1038/s41467-020-17957-0\">10.1038/s41467-020-17957-0</a>","short":"J. Gutierrez-Fernandez, K. Kaszuba, G.S. Minhas, R. Baradaran, M. Tambalo, D.T. Gallagher, L.A. Sazanov, Nature Communications 11 (2020).","mla":"Gutierrez-Fernandez, Javier, et al. “Key Role of Quinone in the Mechanism of Respiratory Complex I.” <i>Nature Communications</i>, vol. 11, no. 1, 4135, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-17957-0\">10.1038/s41467-020-17957-0</a>.","chicago":"Gutierrez-Fernandez, Javier, Karol Kaszuba, Gurdeep S. Minhas, Rozbeh Baradaran, Margherita Tambalo, David T. Gallagher, and Leonid A Sazanov. “Key Role of Quinone in the Mechanism of Respiratory Complex I.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-17957-0\">https://doi.org/10.1038/s41467-020-17957-0</a>.","apa":"Gutierrez-Fernandez, J., Kaszuba, K., Minhas, G. S., Baradaran, R., Tambalo, M., Gallagher, D. T., &#38; Sazanov, L. A. (2020). Key role of quinone in the mechanism of respiratory complex I. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-17957-0\">https://doi.org/10.1038/s41467-020-17957-0</a>"},"type":"journal_article","publication":"Nature Communications","date_updated":"2026-04-02T14:36:31Z","quality_controlled":"1","file_date_updated":"2020-08-31T13:40:00Z","date_created":"2020-08-30T22:01:10Z","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"article_number":"4135","language":[{"iso":"eng"}],"month":"08","intvolume":"        11","ddc":["570"],"publication_identifier":{"eissn":["2041-1723"]},"has_accepted_license":"1","isi":1,"_id":"8318","department":[{"_id":"LeSa"}],"article_processing_charge":"No","day":"18","file":[{"date_created":"2020-08-31T13:40:00Z","date_updated":"2020-08-31T13:40:00Z","content_type":"application/pdf","success":1,"checksum":"52b96f41d7d0db9728064c08da00d030","access_level":"open_access","file_size":7527373,"file_id":"8326","relation":"main_file","creator":"cziletti","file_name":"2020_NatComm_Gutierrez-Fernandez.pdf"}],"date_published":"2020-08-18T00:00:00Z","pmid":1,"publisher":"Springer Nature","author":[{"last_name":"Gutierrez-Fernandez","first_name":"Javier","full_name":"Gutierrez-Fernandez, Javier","id":"3D9511BA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Kaszuba","full_name":"Kaszuba, Karol","first_name":"Karol","id":"3FDF9472-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Gurdeep S.","full_name":"Minhas, Gurdeep S.","last_name":"Minhas"},{"last_name":"Baradaran","first_name":"Rozbeh","full_name":"Baradaran, Rozbeh"},{"last_name":"Tambalo","full_name":"Tambalo, Margherita","first_name":"Margherita","id":"4187dfe4-ec23-11ea-ae46-f08ab378313a"},{"last_name":"Gallagher","full_name":"Gallagher, David T.","first_name":"David T."},{"last_name":"Sazanov","orcid":"0000-0002-0977-7989","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","first_name":"Leonid A","full_name":"Sazanov, Leonid A"}],"status":"public","scopus_import":"1","year":"2020","abstract":[{"lang":"eng","text":"Complex I is the first and the largest enzyme of respiratory chains in bacteria and mitochondria. The mechanism which couples spatially separated transfer of electrons to proton translocation in complex I is not known. Here we report five crystal structures of T. thermophilus enzyme in complex with NADH or quinone-like compounds. We also determined cryo-EM structures of major and minor native states of the complex, differing in the position of the peripheral arm. Crystal structures show that binding of quinone-like compounds (but not of NADH) leads to a related global conformational change, accompanied by local re-arrangements propagating from the quinone site to the nearest proton channel. Normal mode and molecular dynamics analyses indicate that these are likely to represent the first steps in the proton translocation mechanism. Our results suggest that quinone binding and chemistry play a key role in the coupling mechanism of complex I."}],"publication_status":"published","issue":"1","external_id":{"pmid":["32811817"],"isi":["000607072900001"]},"title":"Key role of quinone in the mechanism of respiratory complex I","doi":"10.1038/s41467-020-17957-0","acknowledgement":"This work was funded by the Medical Research Council, UK and IST Austria. We thank the European Synchrotron Radiation Facility and the Diamond Light Source for provision of synchrotron radiation facilities. We are grateful to the staff of beamlines ID29, ID23-2 (ESRF, Grenoble, France) and I03 (Diamond Light Source, Didcot, UK) for assistance. Data processing was performed at the IST high-performance computing cluster.","oa_version":"Published Version"},{"oa_version":"Published Version","title":"Clusters in separated tubes of tilted dipoles","doi":"10.3390/math8040484","external_id":{"isi":["000531824100024"]},"project":[{"name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411"}],"issue":"4","ec_funded":1,"year":"2020","scopus_import":"1","abstract":[{"lang":"eng","text":"A few-body cluster is a building block of a many-body system in a gas phase provided the temperature at most is of the order of the binding energy of this cluster. Here we illustrate this statement by considering a system of tubes filled with dipolar distinguishable particles. We calculate the partition function, which determines the probability to find a few-body cluster at a given temperature. The input for our calculations—the energies of few-body clusters—is estimated using the harmonic approximation. We first describe and demonstrate the validity of our numerical procedure. Then we discuss the results featuring melting of the zero-temperature many-body state into a gas of free particles and few-body clusters. For temperature higher than its binding energy threshold, the dimers overwhelmingly dominate the ensemble, where the remaining probability is in free particles. At very high temperatures free (harmonic oscillator trap-bound) particle dominance is eventually reached. This structure evolution appears both for one and two particles in each layer providing crucial information about the behavior of ultracold dipolar gases. The investigation addresses the transition region between few- and many-body physics as a function of temperature using a system of ten dipoles in five tubes."}],"publication_status":"published","status":"public","date_published":"2020-04-01T00:00:00Z","author":[{"full_name":"Armstrong, Jeremy R.","first_name":"Jeremy R.","last_name":"Armstrong"},{"full_name":"Jensen, Aksel S.","first_name":"Aksel S.","last_name":"Jensen"},{"full_name":"Volosniev, Artem","first_name":"Artem","id":"37D278BC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0393-5525","last_name":"Volosniev"},{"full_name":"Zinner, Nikolaj T.","first_name":"Nikolaj T.","last_name":"Zinner"}],"publisher":"MDPI","day":"01","article_processing_charge":"No","file":[{"content_type":"application/pdf","date_updated":"2020-07-14T12:48:04Z","date_created":"2020-05-25T14:42:22Z","file_size":990540,"file_id":"7887","checksum":"a05a7df724522203d079673a0d4de4bc","access_level":"open_access","creator":"dernst","relation":"main_file","file_name":"2020_Mathematics_Armstrong.pdf"}],"has_accepted_license":"1","isi":1,"_id":"7882","department":[{"_id":"MiLe"}],"publication_identifier":{"eissn":["2227-7390"]},"month":"04","ddc":["510"],"intvolume":"         8","article_number":"484","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"language":[{"iso":"eng"}],"file_date_updated":"2020-07-14T12:48:04Z","quality_controlled":"1","date_updated":"2026-04-02T14:33:47Z","date_created":"2020-05-24T22:01:00Z","citation":{"chicago":"Armstrong, Jeremy R., Aksel S. Jensen, Artem Volosniev, and Nikolaj T. Zinner. “Clusters in Separated Tubes of Tilted Dipoles.” <i>Mathematics</i>. MDPI, 2020. <a href=\"https://doi.org/10.3390/math8040484\">https://doi.org/10.3390/math8040484</a>.","apa":"Armstrong, J. R., Jensen, A. S., Volosniev, A., &#38; Zinner, N. T. (2020). Clusters in separated tubes of tilted dipoles. <i>Mathematics</i>. MDPI. <a href=\"https://doi.org/10.3390/math8040484\">https://doi.org/10.3390/math8040484</a>","mla":"Armstrong, Jeremy R., et al. “Clusters in Separated Tubes of Tilted Dipoles.” <i>Mathematics</i>, vol. 8, no. 4, 484, MDPI, 2020, doi:<a href=\"https://doi.org/10.3390/math8040484\">10.3390/math8040484</a>.","ista":"Armstrong JR, Jensen AS, Volosniev A, Zinner NT. 2020. Clusters in separated tubes of tilted dipoles. Mathematics. 8(4), 484.","short":"J.R. Armstrong, A.S. Jensen, A. Volosniev, N.T. Zinner, Mathematics 8 (2020).","ama":"Armstrong JR, Jensen AS, Volosniev A, Zinner NT. Clusters in separated tubes of tilted dipoles. <i>Mathematics</i>. 2020;8(4). doi:<a href=\"https://doi.org/10.3390/math8040484\">10.3390/math8040484</a>","ieee":"J. R. Armstrong, A. S. Jensen, A. Volosniev, and N. T. Zinner, “Clusters in separated tubes of tilted dipoles,” <i>Mathematics</i>, vol. 8, no. 4. MDPI, 2020."},"publication":"Mathematics","type":"journal_article","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","article_type":"original","volume":8,"oa":1},{"status":"public","year":"2020","scopus_import":"1","publication_status":"published","abstract":[{"text":"When tiny soft ferromagnetic particles are placed along a liquid interface and exposed to a vertical magnetic field, the balance between capillary attraction and magnetic repulsion leads to self-organization into well-defined patterns. Here, we demonstrate experimentally that precessing magnetic fields induce metachronal waves on the periphery of these assemblies, similar to the ones observed in ciliates and some arthropods. The outermost layer of particles behaves like an array of cilia or legs whose sequential movement causes a net and controllable locomotion. This bioinspired many-particle swimming strategy is effective even at low Reynolds number, using only spatially uniform fields to generate the waves.","lang":"eng"}],"day":"19","article_processing_charge":"No","file":[{"file_name":"2020_CommunicationsPhysics_Collard.pdf","creator":"cziletti","relation":"main_file","file_id":"8045","file_size":1907821,"access_level":"open_access","checksum":"ed984f7a393f19140b5279a54a3336ad","content_type":"application/pdf","date_updated":"2020-07-14T12:48:08Z","date_created":"2020-06-29T13:21:24Z"}],"date_published":"2020-06-19T00:00:00Z","author":[{"first_name":"Ylona","full_name":"Collard, Ylona","last_name":"Collard"},{"last_name":"Grosjean","id":"0C5FDA4A-9CF6-11E9-8939-FF05E6697425","orcid":"0000-0001-5154-417X","full_name":"Grosjean, Galien M","first_name":"Galien M"},{"first_name":"Nicolas","full_name":"Vandewalle, Nicolas","last_name":"Vandewalle"}],"publisher":"Springer Nature","title":"Magnetically powered metachronal waves induce locomotion in self-assemblies","doi":"10.1038/s42005-020-0380-9","oa_version":"Published Version","ec_funded":1,"external_id":{"isi":["000543328000002"]},"project":[{"grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships"}],"type":"journal_article","publication":"Communications Physics","citation":{"ieee":"Y. Collard, G. M. Grosjean, and N. Vandewalle, “Magnetically powered metachronal waves induce locomotion in self-assemblies,” <i>Communications Physics</i>, vol. 3. Springer Nature, 2020.","ista":"Collard Y, Grosjean GM, Vandewalle N. 2020. Magnetically powered metachronal waves induce locomotion in self-assemblies. Communications Physics. 3, 112.","short":"Y. Collard, G.M. Grosjean, N. Vandewalle, Communications Physics 3 (2020).","ama":"Collard Y, Grosjean GM, Vandewalle N. Magnetically powered metachronal waves induce locomotion in self-assemblies. <i>Communications Physics</i>. 2020;3. doi:<a href=\"https://doi.org/10.1038/s42005-020-0380-9\">10.1038/s42005-020-0380-9</a>","mla":"Collard, Ylona, et al. “Magnetically Powered Metachronal Waves Induce Locomotion in Self-Assemblies.” <i>Communications Physics</i>, vol. 3, 112, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s42005-020-0380-9\">10.1038/s42005-020-0380-9</a>.","chicago":"Collard, Ylona, Galien M Grosjean, and Nicolas Vandewalle. “Magnetically Powered Metachronal Waves Induce Locomotion in Self-Assemblies.” <i>Communications Physics</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s42005-020-0380-9\">https://doi.org/10.1038/s42005-020-0380-9</a>.","apa":"Collard, Y., Grosjean, G. M., &#38; Vandewalle, N. (2020). Magnetically powered metachronal waves induce locomotion in self-assemblies. <i>Communications Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s42005-020-0380-9\">https://doi.org/10.1038/s42005-020-0380-9</a>"},"file_date_updated":"2020-07-14T12:48:08Z","quality_controlled":"1","date_updated":"2026-04-02T14:34:21Z","date_created":"2020-06-29T07:59:35Z","article_type":"original","volume":3,"oa":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publication_identifier":{"eissn":["2399-3650"]},"has_accepted_license":"1","_id":"8036","department":[{"_id":"ScWa"}],"isi":1,"article_number":"112","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"language":[{"iso":"eng"}],"month":"06","ddc":["530"],"intvolume":"         3"},{"oa_version":"Published Version","acknowledgement":"This research is partially supported by the Office of Naval Research, through grant no. N62909-18-1-2038, and the DFG Collaborative Research Center TRR 109, ‘Discretization in Geometry and Dynamics’, through grant no. I02979-N35 of the Austrian Science Fund (FWF).","doi":"10.20382/jocg.v11i2a7","title":"Topological data analysis in information space","project":[{"grant_number":"I4887","name":"Persistent Homology, Algorithms and Stochastic Geometry","_id":"0aa4bc98-070f-11eb-9043-e6fff9c6a316"}],"issue":"2","year":"2020","scopus_import":"1","publication_status":"published","abstract":[{"lang":"eng","text":"Various kinds of data are routinely represented as discrete probability distributions. Examples include text documents summarized by histograms of word occurrences and images represented as histograms of oriented gradients. Viewing a discrete probability distribution as a point in the standard simplex of the appropriate dimension, we can understand collections of such objects in geometric and topological terms.  Importantly, instead of using the standard Euclidean distance, we look into dissimilarity measures with information-theoretic justification, and we develop the theory needed for applying topological data analysis in this setting. In doing so, we emphasize constructions that enable the usage of existing computational topology software in this context."}],"corr_author":"1","status":"public","date_published":"2020-12-14T00:00:00Z","author":[{"id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9823-6833","full_name":"Edelsbrunner, Herbert","first_name":"Herbert","last_name":"Edelsbrunner"},{"last_name":"Virk","full_name":"Virk, Ziga","first_name":"Ziga","id":"2E36B656-F248-11E8-B48F-1D18A9856A87"},{"id":"379CA8B8-F248-11E8-B48F-1D18A9856A87","orcid":"0009-0009-9111-8429","full_name":"Wagner, Hubert","first_name":"Hubert","last_name":"Wagner"}],"publisher":"Carleton University","day":"14","article_processing_charge":"Yes","file":[{"file_name":"2020_JournalOfComputationalGeometry_Edelsbrunner.pdf","creator":"asandaue","relation":"main_file","file_id":"9882","file_size":1449234,"access_level":"open_access","checksum":"f02d0b2b3838e7891a6c417fc34ffdcd","success":1,"content_type":"application/pdf","date_updated":"2021-08-11T11:55:11Z","date_created":"2021-08-11T11:55:11Z"}],"page":"162-182","has_accepted_license":"1","department":[{"_id":"HeEd"}],"_id":"9630","publication_identifier":{"eissn":["1920-180X"]},"month":"12","ddc":["510","000"],"intvolume":"        11","tmp":{"name":"Creative Commons Attribution 3.0 Unported (CC BY 3.0)","image":"/images/cc_by.png","short":"CC BY (3.0)","legal_code_url":"https://creativecommons.org/licenses/by/3.0/legalcode"},"language":[{"iso":"eng"}],"file_date_updated":"2021-08-11T11:55:11Z","quality_controlled":"1","date_updated":"2026-04-02T14:35:31Z","date_created":"2021-07-04T22:01:26Z","type":"journal_article","publication":"Journal of Computational Geometry","citation":{"chicago":"Edelsbrunner, Herbert, Ziga Virk, and Hubert Wagner. “Topological Data Analysis in Information Space.” <i>Journal of Computational Geometry</i>. Carleton University, 2020. <a href=\"https://doi.org/10.20382/jocg.v11i2a7\">https://doi.org/10.20382/jocg.v11i2a7</a>.","apa":"Edelsbrunner, H., Virk, Z., &#38; Wagner, H. (2020). Topological data analysis in information space. <i>Journal of Computational Geometry</i>. Carleton University. <a href=\"https://doi.org/10.20382/jocg.v11i2a7\">https://doi.org/10.20382/jocg.v11i2a7</a>","mla":"Edelsbrunner, Herbert, et al. “Topological Data Analysis in Information Space.” <i>Journal of Computational Geometry</i>, vol. 11, no. 2, Carleton University, 2020, pp. 162–82, doi:<a href=\"https://doi.org/10.20382/jocg.v11i2a7\">10.20382/jocg.v11i2a7</a>.","ista":"Edelsbrunner H, Virk Z, Wagner H. 2020. Topological data analysis in information space. Journal of Computational Geometry. 11(2), 162–182.","short":"H. Edelsbrunner, Z. Virk, H. Wagner, Journal of Computational Geometry 11 (2020) 162–182.","ama":"Edelsbrunner H, Virk Z, Wagner H. Topological data analysis in information space. <i>Journal of Computational Geometry</i>. 2020;11(2):162-182. doi:<a href=\"https://doi.org/10.20382/jocg.v11i2a7\">10.20382/jocg.v11i2a7</a>","ieee":"H. Edelsbrunner, Z. Virk, and H. Wagner, “Topological data analysis in information space,” <i>Journal of Computational Geometry</i>, vol. 11, no. 2. Carleton University, pp. 162–182, 2020."},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","article_type":"original","volume":11,"oa":1},{"issue":"11","external_id":{"isi":["000587712700069"]},"project":[{"call_identifier":"FWF","name":"Rigorous Systems Engineering","_id":"25832EC2-B435-11E9-9278-68D0E5697425","grant_number":"S 11407_N23"},{"grant_number":"S11407","name":"Game Theory","call_identifier":"FWF","_id":"25863FF4-B435-11E9-9278-68D0E5697425"}],"title":"Precedence-aware automated competitive analysis of real-time scheduling","doi":"10.1109/TCAD.2020.3012803","oa_version":"None","acknowledgement":"This work was supported by the Austrian Science Foundation (FWF) under the NFN RiSE/SHiNE under Grant S11405 and Grant S11407. This article was presented in the International Conference on Embedded Software 2020 and appears as part of the ESWEEK-TCAD special issue. ","day":"01","article_processing_charge":"No","date_published":"2020-11-01T00:00:00Z","publisher":"IEEE","author":[{"id":"49704004-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8943-0722","full_name":"Pavlogiannis, Andreas","first_name":"Andreas","last_name":"Pavlogiannis"},{"full_name":"Schaumberger, Nico","first_name":"Nico","last_name":"Schaumberger"},{"last_name":"Schmid","full_name":"Schmid, Ulrich","first_name":"Ulrich"},{"first_name":"Krishnendu","full_name":"Chatterjee, Krishnendu","orcid":"0000-0002-4561-241X","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","last_name":"Chatterjee"}],"status":"public","year":"2020","scopus_import":"1","publication_status":"published","abstract":[{"text":"We consider a real-time setting where an environment releases sequences of firm-deadline tasks, and an online scheduler chooses on-the-fly the ones to execute on a single processor so as to maximize cumulated utility. The competitive ratio is a well-known performance measure for the scheduler: it gives the worst-case ratio, among all possible choices for the environment, of the cumulated utility of the online scheduler versus an offline scheduler that knows these choices in advance. Traditionally, competitive analysis is performed by hand, while automated techniques are rare and only handle static environments with independent tasks. We present a quantitative-verification framework for precedence-aware competitive analysis, where task releases may depend on preceding scheduling choices, i.e., the environment can respond to scheduling decisions dynamically . We consider two general classes of precedences: 1) follower precedences force the release of a dependent task upon the completion of a set of precursor tasks, while and 2) pairing precedences modify the characteristics of a dependent task provided the completion of a set of precursor tasks. Precedences make competitive analysis challenging, as the online and offline schedulers operate on diverging sequences. We make a formal presentation of our framework, and use a GPU-based implementation to analyze ten well-known schedulers on precedence-based application examples taken from the existing literature: 1) a handshake protocol (HP); 2) network packet-switching; 3) query scheduling (QS); and 4) a sporadic-interrupt setting. Our experimental results show that precedences and task parameters can vary drastically the best scheduler. Our framework thus supports application designers in choosing the best scheduler among a given set automatically.","lang":"eng"}],"language":[{"iso":"eng"}],"month":"11","intvolume":"        39","publication_identifier":{"eissn":["1937-4151"],"issn":["0278-0070"]},"page":"3981-3992","isi":1,"_id":"8788","department":[{"_id":"KrCh"}],"article_type":"original","volume":39,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publication":"IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems","citation":{"ieee":"A. Pavlogiannis, N. Schaumberger, U. Schmid, and K. Chatterjee, “Precedence-aware automated competitive analysis of real-time scheduling,” <i>IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems</i>, vol. 39, no. 11. IEEE, pp. 3981–3992, 2020.","ista":"Pavlogiannis A, Schaumberger N, Schmid U, Chatterjee K. 2020. Precedence-aware automated competitive analysis of real-time scheduling. IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems. 39(11), 3981–3992.","short":"A. Pavlogiannis, N. Schaumberger, U. Schmid, K. Chatterjee, IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems 39 (2020) 3981–3992.","ama":"Pavlogiannis A, Schaumberger N, Schmid U, Chatterjee K. Precedence-aware automated competitive analysis of real-time scheduling. <i>IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems</i>. 2020;39(11):3981-3992. doi:<a href=\"https://doi.org/10.1109/TCAD.2020.3012803\">10.1109/TCAD.2020.3012803</a>","mla":"Pavlogiannis, Andreas, et al. “Precedence-Aware Automated Competitive Analysis of Real-Time Scheduling.” <i>IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems</i>, vol. 39, no. 11, IEEE, 2020, pp. 3981–92, doi:<a href=\"https://doi.org/10.1109/TCAD.2020.3012803\">10.1109/TCAD.2020.3012803</a>.","chicago":"Pavlogiannis, Andreas, Nico Schaumberger, Ulrich Schmid, and Krishnendu Chatterjee. “Precedence-Aware Automated Competitive Analysis of Real-Time Scheduling.” <i>IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems</i>. IEEE, 2020. <a href=\"https://doi.org/10.1109/TCAD.2020.3012803\">https://doi.org/10.1109/TCAD.2020.3012803</a>.","apa":"Pavlogiannis, A., Schaumberger, N., Schmid, U., &#38; Chatterjee, K. (2020). Precedence-aware automated competitive analysis of real-time scheduling. <i>IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems</i>. IEEE. <a href=\"https://doi.org/10.1109/TCAD.2020.3012803\">https://doi.org/10.1109/TCAD.2020.3012803</a>"},"type":"journal_article","date_updated":"2026-04-02T14:37:50Z","quality_controlled":"1","date_created":"2020-11-22T23:01:24Z"},{"pmid":1,"date_published":"2020-08-27T00:00:00Z","author":[{"first_name":"Ioanna","full_name":"Antoniadi, Ioanna","last_name":"Antoniadi"},{"first_name":"Ondřej","full_name":"Novák, Ondřej","last_name":"Novák"},{"last_name":"Gelová","id":"0AE74790-0E0B-11E9-ABC7-1ACFE5697425","orcid":"0000-0003-4783-1752","full_name":"Gelová, Zuzana","first_name":"Zuzana"},{"first_name":"Alexander J","full_name":"Johnson, Alexander J","orcid":"0000-0002-2739-8843","id":"46A62C3A-F248-11E8-B48F-1D18A9856A87","last_name":"Johnson"},{"last_name":"Plíhal","first_name":"Ondřej","full_name":"Plíhal, Ondřej"},{"first_name":"Radim","full_name":"Simerský, Radim","last_name":"Simerský"},{"last_name":"Mik","full_name":"Mik, Václav","first_name":"Václav"},{"last_name":"Vain","full_name":"Vain, Thomas","first_name":"Thomas"},{"full_name":"Mateo-Bonmatí, Eduardo","first_name":"Eduardo","last_name":"Mateo-Bonmatí"},{"last_name":"Karady","full_name":"Karady, Michal","first_name":"Michal"},{"full_name":"Pernisová, Markéta","first_name":"Markéta","last_name":"Pernisová"},{"last_name":"Plačková","full_name":"Plačková, Lenka","first_name":"Lenka"},{"last_name":"Opassathian","first_name":"Korawit","full_name":"Opassathian, Korawit"},{"last_name":"Hejátko","full_name":"Hejátko, Jan","first_name":"Jan"},{"full_name":"Robert, Stéphanie","first_name":"Stéphanie","last_name":"Robert"},{"last_name":"Friml","full_name":"Friml, Jiří","first_name":"Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596"},{"first_name":"Karel","full_name":"Doležal, Karel","last_name":"Doležal"},{"full_name":"Ljung, Karin","first_name":"Karin","last_name":"Ljung"},{"last_name":"Turnbull","first_name":"Colin","full_name":"Turnbull, Colin"}],"publisher":"Springer Nature","day":"27","acknowledged_ssus":[{"_id":"Bio"}],"article_processing_charge":"No","file":[{"date_created":"2020-12-10T12:23:56Z","content_type":"application/pdf","date_updated":"2020-12-10T12:23:56Z","access_level":"open_access","checksum":"5b96f39b598de7510cfefefb819b9a6d","success":1,"file_id":"8936","file_size":3526415,"relation":"main_file","creator":"dernst","file_name":"2020_NatureComm_Antoniadi.pdf"}],"year":"2020","scopus_import":"1","abstract":[{"lang":"eng","text":"Cytokinins are mobile multifunctional plant hormones with roles in development and stress resilience. Although their Histidine Kinase receptors are substantially localised to the endoplasmic reticulum, cellular sites of cytokinin perception and importance of spatially heterogeneous cytokinin distribution continue to be debated. Here we show that cytokinin perception by plasma membrane receptors is an effective additional path for cytokinin response. Readout from a Two Component Signalling cytokinin-specific reporter (TCSn::GFP) closely matches intracellular cytokinin content in roots, yet we also find cytokinins in extracellular fluid, potentially enabling action at the cell surface. Cytokinins covalently linked to beads that could not pass the plasma membrane increased expression of both TCSn::GFP and Cytokinin Response Factors. Super-resolution microscopy of GFP-labelled receptors and diminished TCSn::GFP response to immobilised cytokinins in cytokinin receptor mutants, further indicate that receptors can function at the cell surface. We argue that dual intracellular and surface locations may augment flexibility of cytokinin responses."}],"publication_status":"published","status":"public","external_id":{"pmid":["32855409"],"isi":["000567931000001"]},"project":[{"call_identifier":"FWF","name":"Molecular mechanisms of endocytic cargo recognition in plants","_id":"26538374-B435-11E9-9278-68D0E5697425","grant_number":"I03630"},{"grant_number":"742985","_id":"261099A6-B435-11E9-9278-68D0E5697425","name":"Tracing Evolution of Auxin Transport and Polarity in Plants","call_identifier":"H2020"}],"ec_funded":1,"oa_version":"Published Version","acknowledgement":"We thank Bruno Müller and Aaron Rashotte for critical discussions and provision of plant lines used in this work, Roger Granbom and Tamara Hernández Verdeja (UPSC, Umeå, Sweden) for technical assistance and providing materials, Zuzana Pěkná and Karolina Wojewodová (CRH, Palacký University, Olomouc, Czech Republic) for help with cytokinin receptor binding assays, and David Zalabák (CRH, Palacký University, Olomouc, Czech Republic) for provision of vector pINIIIΔEH expressing CRE1/AHK4. The bioimaging facility of IST Austria, the Swedish Metabolomics Centre and the IST Austria Bio-Imaging facility are acknowledged for support. The work was funded by the European Molecular Biology Organization (EMBO ASTF 297-2013) (I.A.), Development—The Company of Biologists (DEVTF2012) (I.A.; C.T.), Plant Fellows (the International Post doc Fellowship Programme in Plant Sciences, 267423) (I.A.; K.L.), the Swedish Research Council (621-2014-4514) (K.L.), UPSC Berzelii Center for Forest Biotechnology (Vinnova 2012-01560), Kempestiftelserna (JCK-2711) (K.L.) and (JCK-1811) (E.-M.B., K.L.). The Ministry of Education, Youth and Sports of the Czech Republic via the European Regional Development Fund-Project “Plants as a tool for sustainable global development” (CZ.02.1.01/0.0/0.0/16_019/0000827) (O.N., O.P., R.S., V.M., L.P., K.D.) and project CEITEC 2020 (LQ1601) (M.P., J.H.) provided support, as did the Czech Science Foundation via projects GP14-30004P (M.P.) and 16-04184S (O.P., K.D., O.N.), Vetenskapsrådet and Vinnova (Verket för Innovationssystem) (T.V., S.R.), Knut och Alice Wallenbergs Stiftelse via “Shapesystem” grant number 2012.0050. A.J. was supported by the Austria Science Fund (FWF): I03630 to J.F. The research leading to these results received funding from European Union’s Horizon 2020 programme (ERC grant no. 742985) and FWO-FWF joint project G0E5718N to J.F.","doi":"10.1038/s41467-020-17700-9","title":"Cell-surface receptors enable perception of extracellular cytokinins","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","article_type":"original","volume":11,"oa":1,"file_date_updated":"2020-12-10T12:23:56Z","quality_controlled":"1","date_updated":"2026-04-03T09:25:48Z","date_created":"2020-09-06T22:01:13Z","citation":{"chicago":"Antoniadi, Ioanna, Ondřej Novák, Zuzana Gelová, Alexander J Johnson, Ondřej Plíhal, Radim Simerský, Václav Mik, et al. “Cell-Surface Receptors Enable Perception of Extracellular Cytokinins.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-17700-9\">https://doi.org/10.1038/s41467-020-17700-9</a>.","apa":"Antoniadi, I., Novák, O., Gelová, Z., Johnson, A. J., Plíhal, O., Simerský, R., … Turnbull, C. (2020). Cell-surface receptors enable perception of extracellular cytokinins. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-17700-9\">https://doi.org/10.1038/s41467-020-17700-9</a>","mla":"Antoniadi, Ioanna, et al. “Cell-Surface Receptors Enable Perception of Extracellular Cytokinins.” <i>Nature Communications</i>, vol. 11, 4284, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-17700-9\">10.1038/s41467-020-17700-9</a>.","ista":"Antoniadi I, Novák O, Gelová Z, Johnson AJ, Plíhal O, Simerský R, Mik V, Vain T, Mateo-Bonmatí E, Karady M, Pernisová M, Plačková L, Opassathian K, Hejátko J, Robert S, Friml J, Doležal K, Ljung K, Turnbull C. 2020. Cell-surface receptors enable perception of extracellular cytokinins. Nature Communications. 11, 4284.","short":"I. Antoniadi, O. Novák, Z. Gelová, A.J. Johnson, O. Plíhal, R. Simerský, V. Mik, T. Vain, E. Mateo-Bonmatí, M. Karady, M. Pernisová, L. Plačková, K. Opassathian, J. Hejátko, S. Robert, J. Friml, K. Doležal, K. Ljung, C. Turnbull, Nature Communications 11 (2020).","ama":"Antoniadi I, Novák O, Gelová Z, et al. Cell-surface receptors enable perception of extracellular cytokinins. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-17700-9\">10.1038/s41467-020-17700-9</a>","ieee":"I. Antoniadi <i>et al.</i>, “Cell-surface receptors enable perception of extracellular cytokinins,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020."},"publication":"Nature Communications","type":"journal_article","month":"08","ddc":["580"],"intvolume":"        11","article_number":"4284","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"language":[{"iso":"eng"}],"has_accepted_license":"1","_id":"8337","isi":1,"department":[{"_id":"JiFr"}],"publication_identifier":{"eissn":["2041-1723"]}},{"doi":"10.1038/s41598-020-72848-0","title":"A specialized reciprocal connectivity suggests a link between the mechanisms by which the superior colliculus and parabigeminal nucleus produce defensive behaviors in rodents","acknowledgement":"We thank Elisa Sentis and Solano Henriquez for their expert technical assistance. Dr. David Sterratt for his helpful advice in using the Retistruct package. Dr. Joao Botelho for his valuable assistance in scanning the retinas. To Mrs. Diane Greenstein for kindly reading and correcting our manuscript. Macarena Ruiz for her helpful comments during figures elaboration. Dr. Alexia Nunez-Parra for kindly providing us with the transgenic mouse line. Dr. Harald Luksch for granting us access to the confocal microscope at his lab. This study was supported by: FONDECYT 1151432 (to G.M.), FONDECYT 1170027 (to J.M.) and Doctoral fellowship CONICYT 21161599 (to A.D.).","oa_version":"Published Version","external_id":{"pmid":["33004866"],"isi":["000577142600032"]},"status":"public","scopus_import":"1","year":"2020","abstract":[{"text":"The parabigeminal nucleus (PBG) is the mammalian homologue to the isthmic complex of other vertebrates. Optogenetic stimulation of the PBG induces freezing and escape in mice, a result thought to be caused by a PBG projection to the central nucleus of the amygdala. However, the isthmic complex, including the PBG, has been classically considered satellite nuclei of the Superior Colliculus (SC), which upon stimulation of its medial part also triggers fear and avoidance reactions. As the PBG-SC connectivity is not well characterized, we investigated whether the topology of the PBG projection to the SC could be related to the behavioral consequences of PBG stimulation. To that end, we performed immunohistochemistry, in situ hybridization and neural tracer injections in the SC and PBG in a diurnal rodent, the Octodon degus. We found that all PBG neurons expressed both glutamatergic and cholinergic markers and were distributed in clearly defined anterior (aPBG) and posterior (pPBG) subdivisions. The pPBG is connected reciprocally and topographically to the ipsilateral SC, whereas the aPBG receives afferent axons from the ipsilateral SC and projected exclusively to the contralateral SC. This contralateral projection forms a dense field of terminals that is restricted to the medial SC, in correspondence with the SC representation of the aerial binocular field which, we also found, in O. degus prompted escape reactions upon looming stimulation. Therefore, this specialized topography allows binocular interactions in the SC region controlling responses to aerial predators, suggesting a link between the mechanisms by which the SC and PBG produce defensive behaviors.","lang":"eng"}],"publication_status":"published","article_processing_charge":"No","day":"01","file":[{"creator":"dernst","relation":"main_file","file_name":"2020_ScientificReport_Deichler.pdf","content_type":"application/pdf","date_updated":"2020-10-12T12:39:10Z","date_created":"2020-10-12T12:39:10Z","file_size":3906744,"file_id":"8651","checksum":"f6dd99954f1c0ffb4da5a1d2d739bf31","success":1,"access_level":"open_access"}],"pmid":1,"date_published":"2020-10-01T00:00:00Z","publisher":"Springer Nature","author":[{"first_name":"Alfonso","full_name":"Deichler, Alfonso","last_name":"Deichler"},{"first_name":"Denisse","full_name":"Carrasco, Denisse","last_name":"Carrasco"},{"first_name":"Luciana","full_name":"Lopez-Jury, Luciana","last_name":"Lopez-Jury"},{"last_name":"Vega Zuniga","id":"2E7C4E78-F248-11E8-B48F-1D18A9856A87","full_name":"Vega Zuniga, Tomas A","first_name":"Tomas A"},{"first_name":"Natalia","full_name":"Marquez, Natalia","last_name":"Marquez"},{"first_name":"Jorge","full_name":"Mpodozis, Jorge","last_name":"Mpodozis"},{"full_name":"Marin, Gonzalo","first_name":"Gonzalo","last_name":"Marin"}],"publication_identifier":{"eissn":["2045-2322"]},"has_accepted_license":"1","department":[{"_id":"MaJö"}],"_id":"8643","isi":1,"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"article_number":"16220","language":[{"iso":"eng"}],"month":"10","intvolume":"        10","ddc":["570"],"publication":"Scientific Reports","citation":{"apa":"Deichler, A., Carrasco, D., Lopez-Jury, L., Vega Zuniga, T. A., Marquez, N., Mpodozis, J., &#38; Marin, G. (2020). A specialized reciprocal connectivity suggests a link between the mechanisms by which the superior colliculus and parabigeminal nucleus produce defensive behaviors in rodents. <i>Scientific Reports</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41598-020-72848-0\">https://doi.org/10.1038/s41598-020-72848-0</a>","chicago":"Deichler, Alfonso, Denisse Carrasco, Luciana Lopez-Jury, Tomas A Vega Zuniga, Natalia Marquez, Jorge Mpodozis, and Gonzalo Marin. “A Specialized Reciprocal Connectivity Suggests a Link between the Mechanisms by Which the Superior Colliculus and Parabigeminal Nucleus Produce Defensive Behaviors in Rodents.” <i>Scientific Reports</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41598-020-72848-0\">https://doi.org/10.1038/s41598-020-72848-0</a>.","mla":"Deichler, Alfonso, et al. “A Specialized Reciprocal Connectivity Suggests a Link between the Mechanisms by Which the Superior Colliculus and Parabigeminal Nucleus Produce Defensive Behaviors in Rodents.” <i>Scientific Reports</i>, vol. 10, 16220, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41598-020-72848-0\">10.1038/s41598-020-72848-0</a>.","ama":"Deichler A, Carrasco D, Lopez-Jury L, et al. A specialized reciprocal connectivity suggests a link between the mechanisms by which the superior colliculus and parabigeminal nucleus produce defensive behaviors in rodents. <i>Scientific Reports</i>. 2020;10. doi:<a href=\"https://doi.org/10.1038/s41598-020-72848-0\">10.1038/s41598-020-72848-0</a>","short":"A. Deichler, D. Carrasco, L. Lopez-Jury, T.A. Vega Zuniga, N. Marquez, J. Mpodozis, G. Marin, Scientific Reports 10 (2020).","ista":"Deichler A, Carrasco D, Lopez-Jury L, Vega Zuniga TA, Marquez N, Mpodozis J, Marin G. 2020. A specialized reciprocal connectivity suggests a link between the mechanisms by which the superior colliculus and parabigeminal nucleus produce defensive behaviors in rodents. Scientific Reports. 10, 16220.","ieee":"A. Deichler <i>et al.</i>, “A specialized reciprocal connectivity suggests a link between the mechanisms by which the superior colliculus and parabigeminal nucleus produce defensive behaviors in rodents,” <i>Scientific Reports</i>, vol. 10. Springer Nature, 2020."},"type":"journal_article","date_updated":"2026-04-03T09:26:41Z","quality_controlled":"1","file_date_updated":"2020-10-12T12:39:10Z","date_created":"2020-10-11T22:01:14Z","article_type":"original","oa":1,"volume":10,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd"},{"article_type":"original","volume":7,"oa":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publication":"Royal Society Open Science","type":"journal_article","citation":{"ieee":"A. K. Klose, V. Karle, R. Winkelmann, and J. F. Donges, “Emergence of cascading dynamics in interacting tipping elements of ecology and climate: Cascading dynamics in tipping elements,” <i>Royal Society Open Science</i>, vol. 7, no. 6. The Royal Society, 2020.","ama":"Klose AK, Karle V, Winkelmann R, Donges JF. Emergence of cascading dynamics in interacting tipping elements of ecology and climate: Cascading dynamics in tipping elements. <i>Royal Society Open Science</i>. 2020;7(6). doi:<a href=\"https://doi.org/10.1098/rsos.200599\">10.1098/rsos.200599</a>","short":"A.K. Klose, V. Karle, R. Winkelmann, J.F. Donges, Royal Society Open Science 7 (2020).","ista":"Klose AK, Karle V, Winkelmann R, Donges JF. 2020. Emergence of cascading dynamics in interacting tipping elements of ecology and climate: Cascading dynamics in tipping elements. Royal Society Open Science. 7(6), 200599.","mla":"Klose, Ann Kristin, et al. “Emergence of Cascading Dynamics in Interacting Tipping Elements of Ecology and Climate: Cascading Dynamics in Tipping Elements.” <i>Royal Society Open Science</i>, vol. 7, no. 6, 200599, The Royal Society, 2020, doi:<a href=\"https://doi.org/10.1098/rsos.200599\">10.1098/rsos.200599</a>.","apa":"Klose, A. K., Karle, V., Winkelmann, R., &#38; Donges, J. F. (2020). Emergence of cascading dynamics in interacting tipping elements of ecology and climate: Cascading dynamics in tipping elements. <i>Royal Society Open Science</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rsos.200599\">https://doi.org/10.1098/rsos.200599</a>","chicago":"Klose, Ann Kristin, Volker Karle, Ricarda Winkelmann, and Jonathan F. Donges. “Emergence of Cascading Dynamics in Interacting Tipping Elements of Ecology and Climate: Cascading Dynamics in Tipping Elements.” <i>Royal Society Open Science</i>. The Royal Society, 2020. <a href=\"https://doi.org/10.1098/rsos.200599\">https://doi.org/10.1098/rsos.200599</a>."},"file_date_updated":"2020-11-09T09:07:11Z","date_updated":"2026-04-03T09:26:55Z","quality_controlled":"1","date_created":"2020-11-08T23:01:25Z","article_number":"200599","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"language":[{"iso":"eng"}],"month":"06","ddc":["530","550"],"intvolume":"         7","publication_identifier":{"eissn":["2054-5703"]},"has_accepted_license":"1","_id":"8741","isi":1,"department":[{"_id":"MiLe"}],"day":"01","article_processing_charge":"No","file":[{"file_id":"8748","file_size":1611485,"access_level":"open_access","checksum":"5505c445de373bfd836eb4d3b48b1f37","success":1,"content_type":"application/pdf","date_updated":"2020-11-09T09:07:11Z","date_created":"2020-11-09T09:07:11Z","file_name":"2020_RoyalSocOpenScience_Klose.pdf","creator":"dernst","relation":"main_file"}],"date_published":"2020-06-01T00:00:00Z","pmid":1,"arxiv":1,"publisher":"The Royal Society","author":[{"full_name":"Klose, Ann Kristin","first_name":"Ann Kristin","last_name":"Klose"},{"last_name":"Karle","orcid":"0000-0002-6963-0129","id":"D7C012AE-D7ED-11E9-95E8-1EC5E5697425","first_name":"Volker","full_name":"Karle, Volker"},{"last_name":"Winkelmann","first_name":"Ricarda","full_name":"Winkelmann, Ricarda"},{"last_name":"Donges","first_name":"Jonathan F.","full_name":"Donges, Jonathan F."}],"status":"public","year":"2020","scopus_import":"1","publication_status":"published","abstract":[{"lang":"eng","text":"In ecology, climate and other fields, (sub)systems have been identified that can transition into a qualitatively different state when a critical threshold or tipping point in a driving process is crossed. An understanding of those tipping elements is of great interest given the increasing influence of humans on the biophysical Earth system. Complex interactions exist between tipping elements, e.g. physical mechanisms connect subsystems of the climate system. Based on earlier work on such coupled nonlinear systems, we systematically assessed the qualitative long-term behaviour of interacting tipping elements. We developed an understanding of the consequences of interactions\r\non the tipping behaviour allowing for tipping cascades to emerge under certain conditions. The (narrative) application of\r\nthese qualitative results to real-world examples of interacting tipping elements indicates that tipping cascades with profound consequences may occur: the interacting Greenland ice sheet and thermohaline ocean circulation might tip before the tipping points of the isolated subsystems are crossed. The eutrophication of the first lake in a lake chain might propagate through the following lakes without a crossing of their individual critical nutrient input levels. The possibility of emerging cascading tipping dynamics calls for the development of a unified theory of interacting tipping elements and the quantitative analysis of interacting real-world tipping elements."}],"issue":"6","external_id":{"arxiv":["1910.12042"],"isi":["000545625200001"],"pmid":["32742700"]},"doi":"10.1098/rsos.200599","title":"Emergence of cascading dynamics in interacting tipping elements of ecology and climate: Cascading dynamics in tipping elements","oa_version":"Published Version","acknowledgement":"V.K. thanks the German National Academic Foundation (Studienstiftung des deutschen Volkes) for financial\r\nsupport. J.F.D. is grateful for financial support by the Stordalen Foundation via the Planetary Boundary Research\r\nNetwork (PB.net), the Earth League’s EarthDoc program and the European Research Council Advanced Grant\r\nproject ERA (Earth Resilience in the Anthropocene). We are thankful for support by the Leibniz Association\r\n(project DominoES).\r\nAcknowledgements. This work has been performed in the context of the copan collaboration and the FutureLab on Earth\r\nResilience in the Anthropocene at the Potsdam Institute for Climate Impact Research. Furthermore, we acknowledge\r\ndiscussions with and helpful comments by N. Wunderling, J. Heitzig and M. Wiedermann."},{"oa_version":"Published Version","doi":"10.7554/eLife.51595","title":"Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila","external_id":{"isi":["000512304800001"]},"project":[{"grant_number":"P29638","_id":"253B6E48-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"The role of Drosophila TNF alpha in immune cell invasion"}],"year":"2020","scopus_import":"1","abstract":[{"text":"Unpaired ligands are secreted signals that act via a GP130-like receptor, domeless, to activate JAK/STAT signalling in Drosophila. Like many mammalian cytokines, unpaireds can be activated by infection and other stresses and can promote insulin resistance in target tissues. However, the importance of this effect in non-inflammatory physiology is unknown. Here, we identify a requirement for unpaired-JAK signalling as a metabolic regulator in healthy adult Drosophila muscle. Adult muscles show basal JAK-STAT signalling activity in the absence of any immune challenge. Plasmatocytes (Drosophila macrophages) are an important source of this tonic signal. Loss of the dome receptor on adult muscles significantly reduces lifespan and causes local and systemic metabolic pathology. These pathologies result from hyperactivation of AKT and consequent deregulation of metabolism. Thus, we identify a cytokine signal that must be received in muscle to control AKT activity and metabolic homeostasis.","lang":"eng"}],"publication_status":"published","status":"public","date_published":"2020-01-20T00:00:00Z","publisher":"eLife Sciences Publications","author":[{"last_name":"Kierdorf","first_name":"Katrin","full_name":"Kierdorf, Katrin"},{"full_name":"Hersperger, Fabian","first_name":"Fabian","last_name":"Hersperger"},{"last_name":"Sharrock","full_name":"Sharrock, Jessica","first_name":"Jessica"},{"last_name":"Vincent","first_name":"Crystal M.","full_name":"Vincent, Crystal M."},{"full_name":"Ustaoglu, Pinar","first_name":"Pinar","last_name":"Ustaoglu"},{"last_name":"Dou","first_name":"Jiawen","full_name":"Dou, Jiawen"},{"id":"3BCEDBE0-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-1819-198X","full_name":"György, Attila","first_name":"Attila","last_name":"György"},{"first_name":"Olaf","full_name":"Groß, Olaf","last_name":"Groß"},{"last_name":"Siekhaus","full_name":"Siekhaus, Daria E","first_name":"Daria E","id":"3D224B9E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8323-8353"},{"first_name":"Marc S.","full_name":"Dionne, Marc S.","last_name":"Dionne"}],"day":"20","article_processing_charge":"No","file":[{"creator":"dernst","relation":"main_file","file_name":"2020_eLife_Kierdorf.pdf","date_updated":"2020-07-14T12:47:59Z","content_type":"application/pdf","date_created":"2020-02-10T08:53:16Z","file_id":"7470","file_size":4959933,"access_level":"open_access","checksum":"3a072be843f416c7a7d532a51dc0addb"}],"has_accepted_license":"1","department":[{"_id":"DaSi"}],"_id":"7466","isi":1,"publication_identifier":{"eissn":["2050-084X"]},"month":"01","ddc":["570"],"intvolume":"         9","article_number":"e51595","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"language":[{"iso":"eng"}],"file_date_updated":"2020-07-14T12:47:59Z","date_updated":"2026-04-03T09:24:34Z","quality_controlled":"1","date_created":"2020-02-09T23:00:51Z","type":"journal_article","publication":"eLife","citation":{"ieee":"K. Kierdorf <i>et al.</i>, “Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila,” <i>eLife</i>, vol. 9. eLife Sciences Publications, 2020.","short":"K. Kierdorf, F. Hersperger, J. Sharrock, C.M. Vincent, P. Ustaoglu, J. Dou, A. György, O. Groß, D.E. Siekhaus, M.S. Dionne, ELife 9 (2020).","ama":"Kierdorf K, Hersperger F, Sharrock J, et al. Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila. <i>eLife</i>. 2020;9. doi:<a href=\"https://doi.org/10.7554/eLife.51595\">10.7554/eLife.51595</a>","ista":"Kierdorf K, Hersperger F, Sharrock J, Vincent CM, Ustaoglu P, Dou J, György A, Groß O, Siekhaus DE, Dionne MS. 2020. Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila. eLife. 9, e51595.","mla":"Kierdorf, Katrin, et al. “Muscle Function and Homeostasis Require Cytokine Inhibition of AKT Activity in Drosophila.” <i>ELife</i>, vol. 9, e51595, eLife Sciences Publications, 2020, doi:<a href=\"https://doi.org/10.7554/eLife.51595\">10.7554/eLife.51595</a>.","apa":"Kierdorf, K., Hersperger, F., Sharrock, J., Vincent, C. M., Ustaoglu, P., Dou, J., … Dionne, M. S. (2020). Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.51595\">https://doi.org/10.7554/eLife.51595</a>","chicago":"Kierdorf, Katrin, Fabian Hersperger, Jessica Sharrock, Crystal M. Vincent, Pinar Ustaoglu, Jiawen Dou, Attila György, Olaf Groß, Daria E Siekhaus, and Marc S. Dionne. “Muscle Function and Homeostasis Require Cytokine Inhibition of AKT Activity in Drosophila.” <i>ELife</i>. eLife Sciences Publications, 2020. <a href=\"https://doi.org/10.7554/eLife.51595\">https://doi.org/10.7554/eLife.51595</a>."},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","article_type":"original","volume":9,"oa":1},{"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","article_type":"original","oa":1,"volume":10,"date_updated":"2026-04-03T09:26:06Z","quality_controlled":"1","file_date_updated":"2020-07-14T12:48:05Z","date_created":"2020-06-07T22:00:51Z","type":"journal_article","citation":{"apa":"Uroshlev, L. A., Abdullaev, E. T., Umarova, I. R., Il’Icheva, I. A., Panchenko, L. A., Polozov, R. V., … Grokhovsky, S. L. (2020). A method for identification of the methylation level of CpG islands from NGS data. <i>Scientific Reports</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41598-020-65406-1\">https://doi.org/10.1038/s41598-020-65406-1</a>","chicago":"Uroshlev, Leonid A., Eldar T. Abdullaev, Iren R. Umarova, Irina A. Il’Icheva, Larisa A. Panchenko, Robert V. Polozov, Fyodor Kondrashov, Yury D. Nechipurenko, and Sergei L. Grokhovsky. “A Method for Identification of the Methylation Level of CpG Islands from NGS Data.” <i>Scientific Reports</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41598-020-65406-1\">https://doi.org/10.1038/s41598-020-65406-1</a>.","mla":"Uroshlev, Leonid A., et al. “A Method for Identification of the Methylation Level of CpG Islands from NGS Data.” <i>Scientific Reports</i>, vol. 10, 8635, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41598-020-65406-1\">10.1038/s41598-020-65406-1</a>.","short":"L.A. Uroshlev, E.T. Abdullaev, I.R. Umarova, I.A. Il’Icheva, L.A. Panchenko, R.V. Polozov, F. Kondrashov, Y.D. Nechipurenko, S.L. Grokhovsky, Scientific Reports 10 (2020).","ama":"Uroshlev LA, Abdullaev ET, Umarova IR, et al. A method for identification of the methylation level of CpG islands from NGS data. <i>Scientific Reports</i>. 2020;10. doi:<a href=\"https://doi.org/10.1038/s41598-020-65406-1\">10.1038/s41598-020-65406-1</a>","ista":"Uroshlev LA, Abdullaev ET, Umarova IR, Il’Icheva IA, Panchenko LA, Polozov RV, Kondrashov F, Nechipurenko YD, Grokhovsky SL. 2020. A method for identification of the methylation level of CpG islands from NGS data. Scientific Reports. 10, 8635.","ieee":"L. A. Uroshlev <i>et al.</i>, “A method for identification of the methylation level of CpG islands from NGS data,” <i>Scientific Reports</i>, vol. 10. Springer Nature, 2020."},"publication":"Scientific Reports","month":"05","intvolume":"        10","ddc":["570"],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"article_number":"8635","language":[{"iso":"eng"}],"has_accepted_license":"1","isi":1,"_id":"7931","department":[{"_id":"FyKo"}],"publication_identifier":{"eissn":["2045-2322"]},"date_published":"2020-05-25T00:00:00Z","pmid":1,"publisher":"Springer Nature","author":[{"full_name":"Uroshlev, Leonid A.","first_name":"Leonid A.","last_name":"Uroshlev"},{"first_name":"Eldar T.","full_name":"Abdullaev, Eldar T.","last_name":"Abdullaev"},{"last_name":"Umarova","full_name":"Umarova, Iren R.","first_name":"Iren R."},{"full_name":"Il’Icheva, Irina A.","first_name":"Irina A.","last_name":"Il’Icheva"},{"last_name":"Panchenko","full_name":"Panchenko, Larisa A.","first_name":"Larisa A."},{"last_name":"Polozov","full_name":"Polozov, Robert V.","first_name":"Robert V."},{"orcid":"0000-0001-8243-4694","id":"44FDEF62-F248-11E8-B48F-1D18A9856A87","first_name":"Fyodor","full_name":"Kondrashov, Fyodor","last_name":"Kondrashov"},{"last_name":"Nechipurenko","full_name":"Nechipurenko, Yury D.","first_name":"Yury D."},{"full_name":"Grokhovsky, Sergei L.","first_name":"Sergei L.","last_name":"Grokhovsky"}],"article_processing_charge":"No","day":"25","file":[{"date_created":"2020-06-08T06:27:32Z","date_updated":"2020-07-14T12:48:05Z","content_type":"application/pdf","access_level":"open_access","checksum":"099e51611a5b7ca04244d03b2faddf33","file_id":"7947","file_size":1001724,"relation":"main_file","creator":"dernst","file_name":"2020_ScientificReports_Uroshlev.pdf"}],"scopus_import":"1","year":"2020","publication_status":"published","abstract":[{"lang":"eng","text":"In the course of sample preparation for Next Generation Sequencing (NGS), DNA is fragmented by various methods. Fragmentation shows a persistent bias with regard to the cleavage rates of various dinucleotides. With the exception of CpG dinucleotides the previously described biases were consistent with results of the DNA cleavage in solution. Here we computed cleavage rates of all dinucleotides including the methylated CpG and unmethylated CpG dinucleotides using data of the Whole Genome Sequencing datasets of the 1000 Genomes project. We found that the cleavage rate of CpG is significantly higher for the methylated CpG dinucleotides. Using this information, we developed a classifier for distinguishing cancer and healthy tissues based on their CpG islands statuses of the fragmentation. A simple Support Vector Machine classifier based on this algorithm shows an accuracy of 84%. The proposed method allows the detection of epigenetic markers purely based on mechanochemical DNA fragmentation, which can be detected by a simple analysis of the NGS sequencing data."}],"status":"public","external_id":{"pmid":["32451390"],"isi":["000560774200007"]},"oa_version":"Published Version","title":"A method for identification of the methylation level of CpG islands from NGS data","doi":"10.1038/s41598-020-65406-1"},{"article_number":"eabc3979","language":[{"iso":"eng"}],"month":"07","intvolume":"         5","publication_identifier":{"eissn":["2470-9468"]},"_id":"8132","department":[{"_id":"MiSi"}],"isi":1,"article_type":"original","oa":1,"volume":5,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","type":"journal_article","publication":"Science Immunology","citation":{"chicago":"Salzer, Elisabeth, Samaneh Zoghi, Máté G. Kiss, Frieda Kage, Christina Rashkova, Stephanie Stahnke, Matthias Haimel, et al. “The Cytoskeletal Regulator HEM1 Governs B Cell Development and Prevents Autoimmunity.” <i>Science Immunology</i>. AAAS, 2020. <a href=\"https://doi.org/10.1126/sciimmunol.abc3979\">https://doi.org/10.1126/sciimmunol.abc3979</a>.","apa":"Salzer, E., Zoghi, S., Kiss, M. G., Kage, F., Rashkova, C., Stahnke, S., … Boztug, K. (2020). The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity. <i>Science Immunology</i>. AAAS. <a href=\"https://doi.org/10.1126/sciimmunol.abc3979\">https://doi.org/10.1126/sciimmunol.abc3979</a>","mla":"Salzer, Elisabeth, et al. “The Cytoskeletal Regulator HEM1 Governs B Cell Development and Prevents Autoimmunity.” <i>Science Immunology</i>, vol. 5, no. 49, eabc3979, AAAS, 2020, doi:<a href=\"https://doi.org/10.1126/sciimmunol.abc3979\">10.1126/sciimmunol.abc3979</a>.","ista":"Salzer E, Zoghi S, Kiss MG, Kage F, Rashkova C, Stahnke S, Haimel M, Platzer R, Caldera M, Ardy RC, Hoeger B, Block J, Medgyesi D, Sin C, Shahkarami S, Kain R, Ziaee V, Hammerl P, Bock C, Menche J, Dupré L, Huppa JB, Sixt MK, Lomakin A, Rottner K, Binder CJ, Stradal TEB, Rezaei N, Boztug K. 2020. The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity. Science Immunology. 5(49), eabc3979.","ama":"Salzer E, Zoghi S, Kiss MG, et al. The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity. <i>Science Immunology</i>. 2020;5(49). doi:<a href=\"https://doi.org/10.1126/sciimmunol.abc3979\">10.1126/sciimmunol.abc3979</a>","short":"E. Salzer, S. Zoghi, M.G. Kiss, F. Kage, C. Rashkova, S. Stahnke, M. Haimel, R. Platzer, M. Caldera, R.C. Ardy, B. Hoeger, J. Block, D. Medgyesi, C. Sin, S. Shahkarami, R. Kain, V. Ziaee, P. Hammerl, C. Bock, J. Menche, L. Dupré, J.B. Huppa, M.K. Sixt, A. Lomakin, K. Rottner, C.J. Binder, T.E.B. Stradal, N. Rezaei, K. Boztug, Science Immunology 5 (2020).","ieee":"E. Salzer <i>et al.</i>, “The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity,” <i>Science Immunology</i>, vol. 5, no. 49. AAAS, 2020."},"date_updated":"2026-04-03T09:25:04Z","quality_controlled":"1","date_created":"2020-07-19T22:00:58Z","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116756","open_access":"1"}],"issue":"49","external_id":{"isi":["000546994600004"],"pmid":["32646852"]},"OA_type":"green","title":"The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity","doi":"10.1126/sciimmunol.abc3979","oa_version":"Submitted Version","article_processing_charge":"No","day":"10","pmid":1,"date_published":"2020-07-10T00:00:00Z","author":[{"first_name":"Elisabeth","full_name":"Salzer, Elisabeth","last_name":"Salzer"},{"full_name":"Zoghi, Samaneh","first_name":"Samaneh","last_name":"Zoghi"},{"last_name":"Kiss","full_name":"Kiss, Máté G.","first_name":"Máté G."},{"last_name":"Kage","first_name":"Frieda","full_name":"Kage, Frieda"},{"first_name":"Christina","full_name":"Rashkova, Christina","last_name":"Rashkova"},{"full_name":"Stahnke, Stephanie","first_name":"Stephanie","last_name":"Stahnke"},{"last_name":"Haimel","full_name":"Haimel, Matthias","first_name":"Matthias"},{"last_name":"Platzer","full_name":"Platzer, René","first_name":"René"},{"full_name":"Caldera, Michael","first_name":"Michael","last_name":"Caldera"},{"last_name":"Ardy","first_name":"Rico Chandra","full_name":"Ardy, Rico Chandra"},{"last_name":"Hoeger","full_name":"Hoeger, Birgit","first_name":"Birgit"},{"first_name":"Jana","full_name":"Block, Jana","last_name":"Block"},{"full_name":"Medgyesi, David","first_name":"David","last_name":"Medgyesi"},{"last_name":"Sin","first_name":"Celine","full_name":"Sin, Celine"},{"full_name":"Shahkarami, Sepideh","first_name":"Sepideh","last_name":"Shahkarami"},{"full_name":"Kain, Renate","first_name":"Renate","last_name":"Kain"},{"last_name":"Ziaee","full_name":"Ziaee, Vahid","first_name":"Vahid"},{"last_name":"Hammerl","first_name":"Peter","full_name":"Hammerl, Peter"},{"first_name":"Christoph","full_name":"Bock, Christoph","last_name":"Bock"},{"last_name":"Menche","first_name":"Jörg","full_name":"Menche, Jörg"},{"full_name":"Dupré, Loïc","first_name":"Loïc","last_name":"Dupré"},{"first_name":"Johannes B.","full_name":"Huppa, Johannes B.","last_name":"Huppa"},{"last_name":"Sixt","full_name":"Sixt, Michael K","first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6620-9179"},{"full_name":"Lomakin, Alexis","first_name":"Alexis","last_name":"Lomakin"},{"first_name":"Klemens","full_name":"Rottner, Klemens","last_name":"Rottner"},{"last_name":"Binder","first_name":"Christoph J.","full_name":"Binder, Christoph J."},{"first_name":"Theresia E.B.","full_name":"Stradal, Theresia E.B.","last_name":"Stradal"},{"full_name":"Rezaei, Nima","first_name":"Nima","last_name":"Rezaei"},{"first_name":"Kaan","full_name":"Boztug, Kaan","last_name":"Boztug"}],"publisher":"AAAS","status":"public","scopus_import":"1","year":"2020","abstract":[{"lang":"eng","text":"The WAVE regulatory complex (WRC) is crucial for assembly of the peripheral branched actin network constituting one of the main drivers of eukaryotic cell migration. Here, we uncover an essential role of the hematopoietic-specific WRC component HEM1 for immune cell development. Germline-encoded HEM1 deficiency underlies an inborn error of immunity with systemic autoimmunity, at cellular level marked by WRC destabilization, reduced filamentous actin, and failure to assemble lamellipodia. Hem1−/− mice display systemic autoimmunity, phenocopying the human disease. In the absence of Hem1, B cells become deprived of extracellular stimuli necessary to maintain the strength of B cell receptor signaling at a level permissive for survival of non-autoreactive B cells. This shifts the balance of B cell fate choices toward autoreactive B cells and thus autoimmunity."}],"OA_place":"repository","publication_status":"published"}]