---
_id: '9259'
abstract:
- lang: eng
text: Gradients of chemokines and growth factors guide migrating cells and morphogenetic
processes. Migration of antigen-presenting dendritic cells from the interstitium
into the lymphatic system is dependent on chemokine CCL21, which is secreted by
endothelial cells of the lymphatic capillary, binds heparan sulfates and forms
gradients decaying into the interstitium. Despite the importance of CCL21 gradients,
and chemokine gradients in general, the mechanisms of gradient formation are unclear.
Studies on fibroblast growth factors have shown that limited diffusion is crucial
for gradient formation. Here, we used the mouse dermis as a model tissue to address
the necessity of CCL21 anchoring to lymphatic capillary heparan sulfates in the
formation of interstitial CCL21 gradients. Surprisingly, the absence of lymphatic
endothelial heparan sulfates resulted only in a modest decrease of CCL21 levels
at the lymphatic capillaries and did neither affect interstitial CCL21 gradient
shape nor dendritic cell migration toward lymphatic capillaries. Thus, heparan
sulfates at the level of the lymphatic endothelium are dispensable for the formation
of a functional CCL21 gradient.
acknowledgement: "This work was supported by Sigrid Juselius fellowship (KV), University
of Helsinki 3-year research grant (KV), Academy of Finland Research fellow funding
(315710, to KV), the European Research Council (ERC CoG 724373 to MS), and by the
Austrian Science foundation (FWF) (Y564-B12 START award to MS).\r\nTaija Mäkinen
is acknowledged for providing Prox1CreERT2 transgenic mice and Yu Yamaguchi for
providing the conditional Ext1 mouse strain."
article_number: '630002'
article_processing_charge: No
article_type: original
author:
- first_name: Kari
full_name: Vaahtomeri, Kari
id: 368EE576-F248-11E8-B48F-1D18A9856A87
last_name: Vaahtomeri
orcid: 0000-0001-7829-3518
- first_name: Christine
full_name: Moussion, Christine
id: 3356F664-F248-11E8-B48F-1D18A9856A87
last_name: Moussion
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
citation:
ama: Vaahtomeri K, Moussion C, Hauschild R, Sixt MK. Shape and function of interstitial
chemokine CCL21 gradients are independent of heparan sulfates produced by lymphatic
endothelium. Frontiers in Immunology. 2021;12. doi:10.3389/fimmu.2021.630002
apa: Vaahtomeri, K., Moussion, C., Hauschild, R., & Sixt, M. K. (2021). Shape
and function of interstitial chemokine CCL21 gradients are independent of heparan
sulfates produced by lymphatic endothelium. Frontiers in Immunology. Frontiers.
https://doi.org/10.3389/fimmu.2021.630002
chicago: Vaahtomeri, Kari, Christine Moussion, Robert Hauschild, and Michael K Sixt.
“Shape and Function of Interstitial Chemokine CCL21 Gradients Are Independent
of Heparan Sulfates Produced by Lymphatic Endothelium.” Frontiers in Immunology.
Frontiers, 2021. https://doi.org/10.3389/fimmu.2021.630002.
ieee: K. Vaahtomeri, C. Moussion, R. Hauschild, and M. K. Sixt, “Shape and function
of interstitial chemokine CCL21 gradients are independent of heparan sulfates
produced by lymphatic endothelium,” Frontiers in Immunology, vol. 12. Frontiers,
2021.
ista: Vaahtomeri K, Moussion C, Hauschild R, Sixt MK. 2021. Shape and function of
interstitial chemokine CCL21 gradients are independent of heparan sulfates produced
by lymphatic endothelium. Frontiers in Immunology. 12, 630002.
mla: Vaahtomeri, Kari, et al. “Shape and Function of Interstitial Chemokine CCL21
Gradients Are Independent of Heparan Sulfates Produced by Lymphatic Endothelium.”
Frontiers in Immunology, vol. 12, 630002, Frontiers, 2021, doi:10.3389/fimmu.2021.630002.
short: K. Vaahtomeri, C. Moussion, R. Hauschild, M.K. Sixt, Frontiers in Immunology
12 (2021).
corr_author: '1'
date_created: 2021-03-21T23:01:20Z
date_published: 2021-02-25T00:00:00Z
date_updated: 2025-04-14T07:42:07Z
day: '25'
ddc:
- '570'
department:
- _id: MiSi
- _id: Bio
doi: 10.3389/fimmu.2021.630002
ec_funded: 1
external_id:
isi:
- '000627134400001'
pmid:
- '33717158'
file:
- access_level: open_access
checksum: 663f5a48375e42afa4bfef58d42ec186
content_type: application/pdf
creator: dernst
date_created: 2021-03-22T12:08:26Z
date_updated: 2021-03-22T12:08:26Z
file_id: '9277'
file_name: 2021_FrontiersImmumo_Vaahtomeri.pdf
file_size: 3740146
relation: main_file
success: 1
file_date_updated: 2021-03-22T12:08:26Z
has_accepted_license: '1'
intvolume: ' 12'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 25FE9508-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '724373'
name: Cellular Navigation Along Spatial Gradients
- _id: 25A8E5EA-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Y 564-B12
name: Cytoskeletal force generation and force transduction of migrating leukocytes
publication: Frontiers in Immunology
publication_identifier:
eissn:
- 1664-3224
publication_status: published
publisher: Frontiers
quality_controlled: '1'
scopus_import: '1'
status: public
title: Shape and function of interstitial chemokine CCL21 gradients are independent
of heparan sulfates produced by lymphatic endothelium
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12
year: '2021'
...
---
_id: '9260'
abstract:
- lang: eng
text: We study the density of rational points on a higher-dimensional orbifold (Pn−1,Δ)
when Δ is a Q-divisor involving hyperplanes. This allows us to address a question
of Tanimoto about whether the set of rational points on such an orbifold constitutes
a thin set. Our approach relies on the Hardy–Littlewood circle method to first
study an asymptotic version of Waring’s problem for mixed powers. In doing so
we make crucial use of the recent resolution of the main conjecture in Vinogradov’s
mean value theorem, due to Bourgain–Demeter–Guth and Wooley.
acknowledgement: While working on this paper the authors were both supported by EPSRC
grant EP/P026710/1, and the second author received additional support from the NWO
Veni Grant 016.Veni.192.047. Thanks are due to Marta Pieropan, Arne Smeets and Sho
Tanimoto for useful conversations related to this topic, and to the anonymous referee
for numerous helpful suggestions.
article_processing_charge: No
article_type: original
author:
- first_name: Timothy D
full_name: Browning, Timothy D
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
- first_name: Shuntaro
full_name: Yamagishi, Shuntaro
last_name: Yamagishi
citation:
ama: Browning TD, Yamagishi S. Arithmetic of higher-dimensional orbifolds and a
mixed Waring problem. Mathematische Zeitschrift. 2021;299:1071–1101. doi:10.1007/s00209-021-02695-w
apa: Browning, T. D., & Yamagishi, S. (2021). Arithmetic of higher-dimensional
orbifolds and a mixed Waring problem. Mathematische Zeitschrift. Springer
Nature. https://doi.org/10.1007/s00209-021-02695-w
chicago: Browning, Timothy D, and Shuntaro Yamagishi. “Arithmetic of Higher-Dimensional
Orbifolds and a Mixed Waring Problem.” Mathematische Zeitschrift. Springer
Nature, 2021. https://doi.org/10.1007/s00209-021-02695-w.
ieee: T. D. Browning and S. Yamagishi, “Arithmetic of higher-dimensional orbifolds
and a mixed Waring problem,” Mathematische Zeitschrift, vol. 299. Springer
Nature, pp. 1071–1101, 2021.
ista: Browning TD, Yamagishi S. 2021. Arithmetic of higher-dimensional orbifolds
and a mixed Waring problem. Mathematische Zeitschrift. 299, 1071–1101.
mla: Browning, Timothy D., and Shuntaro Yamagishi. “Arithmetic of Higher-Dimensional
Orbifolds and a Mixed Waring Problem.” Mathematische Zeitschrift, vol.
299, Springer Nature, 2021, pp. 1071–1101, doi:10.1007/s00209-021-02695-w.
short: T.D. Browning, S. Yamagishi, Mathematische Zeitschrift 299 (2021) 1071–1101.
date_created: 2021-03-21T23:01:21Z
date_published: 2021-03-05T00:00:00Z
date_updated: 2025-04-14T09:25:44Z
day: '05'
ddc:
- '510'
department:
- _id: TiBr
doi: 10.1007/s00209-021-02695-w
external_id:
isi:
- '000625573800002'
file:
- access_level: open_access
checksum: 8ed9f49568806894744096dbbca0ad7b
content_type: application/pdf
creator: dernst
date_created: 2021-03-22T12:41:26Z
date_updated: 2021-03-22T12:41:26Z
file_id: '9279'
file_name: 2021_MathZeitschrift_Browning.pdf
file_size: 492685
relation: main_file
success: 1
file_date_updated: 2021-03-22T12:41:26Z
has_accepted_license: '1'
intvolume: ' 299'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 1071–1101
project:
- _id: 26A8D266-B435-11E9-9278-68D0E5697425
grant_number: EP-P026710-2
name: Between rational and integral points
publication: Mathematische Zeitschrift
publication_identifier:
eissn:
- 1432-1823
issn:
- 0025-5874
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Arithmetic of higher-dimensional orbifolds and a mixed Waring problem
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 299
year: '2021'
...
---
_id: '9281'
abstract:
- lang: eng
text: We comment on two formal proofs of Fermat's sum of two squares theorem, written
using the Mathematical Components libraries of the Coq proof assistant. The first
one follows Zagier's celebrated one-sentence proof; the second follows David Christopher's
recent new proof relying on partition-theoretic arguments. Both formal proofs
rely on a general property of involutions of finite sets, of independent interest.
The proof technique consists for the most part of automating recurrent tasks (such
as case distinctions and computations on natural numbers) via ad hoc tactics.
article_number: '2103.11389'
article_processing_charge: No
arxiv: 1
author:
- first_name: Guillaume
full_name: Dubach, Guillaume
id: D5C6A458-10C4-11EA-ABF4-A4B43DDC885E
last_name: Dubach
orcid: 0000-0001-6892-8137
- first_name: Fabian
full_name: Mühlböck, Fabian
id: 6395C5F6-89DF-11E9-9C97-6BDFE5697425
last_name: Mühlböck
orcid: 0000-0003-1548-0177
citation:
ama: Dubach G, Mühlböck F. Formal verification of Zagier’s one-sentence proof. arXiv.
doi:10.48550/arXiv.2103.11389
apa: Dubach, G., & Mühlböck, F. (n.d.). Formal verification of Zagier’s one-sentence
proof. arXiv. https://doi.org/10.48550/arXiv.2103.11389
chicago: Dubach, Guillaume, and Fabian Mühlböck. “Formal Verification of Zagier’s
One-Sentence Proof.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2103.11389.
ieee: G. Dubach and F. Mühlböck, “Formal verification of Zagier’s one-sentence proof,”
arXiv. .
ista: Dubach G, Mühlböck F. Formal verification of Zagier’s one-sentence proof.
arXiv, 2103.11389.
mla: Dubach, Guillaume, and Fabian Mühlböck. “Formal Verification of Zagier’s One-Sentence
Proof.” ArXiv, 2103.11389, doi:10.48550/arXiv.2103.11389.
short: G. Dubach, F. Mühlböck, ArXiv (n.d.).
corr_author: '1'
date_created: 2021-03-23T05:38:48Z
date_published: 2021-03-21T00:00:00Z
date_updated: 2025-04-15T06:26:12Z
day: '21'
department:
- _id: LaEr
- _id: ToHe
doi: 10.48550/arXiv.2103.11389
ec_funded: 1
external_id:
arxiv:
- '2103.11389'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2103.11389
month: '03'
oa: 1
oa_version: Preprint
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: arXiv
publication_status: submitted
related_material:
record:
- id: '9946'
relation: other
status: public
status: public
title: Formal verification of Zagier's one-sentence proof
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '9282'
abstract:
- lang: eng
text: Several Ising-type magnetic van der Waals (vdW) materials exhibit stable magnetic
ground states. Despite these clear experimental demonstrations, a complete theoretical
and microscopic understanding of their magnetic anisotropy is still lacking. In
particular, the validity limit of identifying their one-dimensional (1-D) Ising
nature has remained uninvestigated in a quantitative way. Here we performed the
complete mapping of magnetic anisotropy for a prototypical Ising vdW magnet FePS3
for the first time. Combining torque magnetometry measurements with their magnetostatic
model analysis and the relativistic density functional total energy calculations,
we successfully constructed the three-dimensional (3-D) mappings of the magnetic
anisotropy in terms of magnetic torque and energy. The results not only quantitatively
confirm that the easy axis is perpendicular to the ab plane, but also reveal the
anisotropies within the ab, ac, and bc planes. Our approach can be applied to
the detailed quantitative study of magnetism in vdW materials.
article_number: '035011'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Muhammad
full_name: Nauman, Muhammad
id: 32c21954-2022-11eb-9d5f-af9f93c24e71
last_name: Nauman
orcid: 0000-0002-2111-4846
- first_name: Do Hoon
full_name: Kiem, Do Hoon
last_name: Kiem
- first_name: Sungmin
full_name: Lee, Sungmin
last_name: Lee
- first_name: Suhan
full_name: Son, Suhan
last_name: Son
- first_name: J-G
full_name: Park, J-G
last_name: Park
- first_name: Woun
full_name: Kang, Woun
last_name: Kang
- first_name: Myung Joon
full_name: Han, Myung Joon
last_name: Han
- first_name: Youn Jung
full_name: Jo, Youn Jung
last_name: Jo
citation:
ama: Nauman M, Kiem DH, Lee S, et al. Complete mapping of magnetic anisotropy for
prototype Ising van der Waals FePS3. 2D Materials. 2021;8(3). doi:10.1088/2053-1583/abeed3
apa: Nauman, M., Kiem, D. H., Lee, S., Son, S., Park, J.-G., Kang, W., … Jo, Y.
J. (2021). Complete mapping of magnetic anisotropy for prototype Ising van der
Waals FePS3. 2D Materials. IOP Publishing. https://doi.org/10.1088/2053-1583/abeed3
chicago: Nauman, Muhammad, Do Hoon Kiem, Sungmin Lee, Suhan Son, J-G Park, Woun
Kang, Myung Joon Han, and Youn Jung Jo. “Complete Mapping of Magnetic Anisotropy
for Prototype Ising van Der Waals FePS3.” 2D Materials. IOP Publishing,
2021. https://doi.org/10.1088/2053-1583/abeed3.
ieee: M. Nauman et al., “Complete mapping of magnetic anisotropy for prototype
Ising van der Waals FePS3,” 2D Materials, vol. 8, no. 3. IOP Publishing,
2021.
ista: Nauman M, Kiem DH, Lee S, Son S, Park J-G, Kang W, Han MJ, Jo YJ. 2021. Complete
mapping of magnetic anisotropy for prototype Ising van der Waals FePS3. 2D Materials.
8(3), 035011.
mla: Nauman, Muhammad, et al. “Complete Mapping of Magnetic Anisotropy for Prototype
Ising van Der Waals FePS3.” 2D Materials, vol. 8, no. 3, 035011, IOP Publishing,
2021, doi:10.1088/2053-1583/abeed3.
short: M. Nauman, D.H. Kiem, S. Lee, S. Son, J.-G. Park, W. Kang, M.J. Han, Y.J.
Jo, 2D Materials 8 (2021).
date_created: 2021-03-23T07:10:17Z
date_published: 2021-04-06T00:00:00Z
date_updated: 2021-12-01T10:36:56Z
day: '06'
department:
- _id: KiMo
doi: 10.1088/2053-1583/abeed3
extern: '1'
external_id:
arxiv:
- '2103.09029'
intvolume: ' 8'
issue: '3'
keyword:
- Mechanical Engineering
- General Materials Science
- Mechanics of Materials
- General Chemistry
- Condensed Matter Physics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2103.09029
month: '04'
oa: 1
oa_version: Preprint
publication: 2D Materials
publication_identifier:
issn:
- 2053-1583
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
status: public
title: Complete mapping of magnetic anisotropy for prototype Ising van der Waals FePS3
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 8
year: '2021'
...
---
_id: '9283'
abstract:
- lang: eng
text: Gene expression levels are influenced by multiple coexisting molecular mechanisms.
Some of these interactions such as those of transcription factors and promoters
have been studied extensively. However, predicting phenotypes of gene regulatory
networks (GRNs) remains a major challenge. Here, we use a well-defined synthetic
GRN to study in Escherichia coli how network phenotypes depend on local genetic
context, i.e. the genetic neighborhood of a transcription factor and its relative
position. We show that one GRN with fixed topology can display not only quantitatively
but also qualitatively different phenotypes, depending solely on the local genetic
context of its components. Transcriptional read-through is the main molecular
mechanism that places one transcriptional unit (TU) within two separate regulons
without the need for complex regulatory sequences. We propose that relative order
of individual TUs, with its potential for combinatorial complexity, plays an important
role in shaping phenotypes of GRNs.
acknowledgement: "We thank J Bollback, L Hurst, M Lagator, C Nizak, O Rivoire, M Savageau,
G Tkacik, and B Vicozo\r\nfor helpful discussions; A Dolinar and A Greshnova for
technical assistance; T Bollenbach for supplying the strain JW0336; C Rusnac, and
members of the Guet lab for comments. The research leading to these results has
received funding from the People Programme (Marie Curie Actions) of the European
Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement n˚\r\n628377
(ANS) and an Austrian Science Fund (FWF) grant n˚ I 3901-B32 (CCG)."
article_number: e65993
article_processing_charge: Yes
article_type: original
author:
- first_name: Anna A
full_name: Nagy-Staron, Anna A
id: 3ABC5BA6-F248-11E8-B48F-1D18A9856A87
last_name: Nagy-Staron
orcid: 0000-0002-1391-8377
- first_name: Kathrin
full_name: Tomasek, Kathrin
id: 3AEC8556-F248-11E8-B48F-1D18A9856A87
last_name: Tomasek
orcid: 0000-0003-3768-877X
- first_name: Caroline
full_name: Caruso Carter, Caroline
last_name: Caruso Carter
- first_name: Elisabeth
full_name: Sonnleitner, Elisabeth
last_name: Sonnleitner
- first_name: Bor
full_name: Kavcic, Bor
id: 350F91D2-F248-11E8-B48F-1D18A9856A87
last_name: Kavcic
orcid: 0000-0001-6041-254X
- first_name: Tiago
full_name: Paixão, Tiago
last_name: Paixão
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
citation:
ama: Nagy-Staron AA, Tomasek K, Caruso Carter C, et al. Local genetic context shapes
the function of a gene regulatory network. eLife. 2021;10. doi:10.7554/elife.65993
apa: Nagy-Staron, A. A., Tomasek, K., Caruso Carter, C., Sonnleitner, E., Kavcic,
B., Paixão, T., & Guet, C. C. (2021). Local genetic context shapes the function
of a gene regulatory network. ELife. eLife Sciences Publications. https://doi.org/10.7554/elife.65993
chicago: Nagy-Staron, Anna A, Kathrin Tomasek, Caroline Caruso Carter, Elisabeth
Sonnleitner, Bor Kavcic, Tiago Paixão, and Calin C Guet. “Local Genetic Context
Shapes the Function of a Gene Regulatory Network.” ELife. eLife Sciences
Publications, 2021. https://doi.org/10.7554/elife.65993.
ieee: A. A. Nagy-Staron et al., “Local genetic context shapes the function
of a gene regulatory network,” eLife, vol. 10. eLife Sciences Publications,
2021.
ista: Nagy-Staron AA, Tomasek K, Caruso Carter C, Sonnleitner E, Kavcic B, Paixão
T, Guet CC. 2021. Local genetic context shapes the function of a gene regulatory
network. eLife. 10, e65993.
mla: Nagy-Staron, Anna A., et al. “Local Genetic Context Shapes the Function of
a Gene Regulatory Network.” ELife, vol. 10, e65993, eLife Sciences Publications,
2021, doi:10.7554/elife.65993.
short: A.A. Nagy-Staron, K. Tomasek, C. Caruso Carter, E. Sonnleitner, B. Kavcic,
T. Paixão, C.C. Guet, ELife 10 (2021).
corr_author: '1'
date_created: 2021-03-23T10:11:46Z
date_published: 2021-03-08T00:00:00Z
date_updated: 2025-06-12T06:36:17Z
day: '08'
ddc:
- '570'
department:
- _id: GaTk
- _id: CaGu
doi: 10.7554/elife.65993
ec_funded: 1
external_id:
isi:
- '000631050900001'
pmid:
- '33683203'
file:
- access_level: open_access
checksum: 3c2f44058c2dd45a5a1027f09d263f8e
content_type: application/pdf
creator: bkavcic
date_created: 2021-03-23T10:12:58Z
date_updated: 2021-03-23T10:12:58Z
file_id: '9284'
file_name: elife-65993-v2.pdf
file_size: 1390469
relation: main_file
success: 1
file_date_updated: 2021-03-23T10:12:58Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
keyword:
- Genetics and Molecular Biology
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2517526A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '628377'
name: 'The Systems Biology of Transcriptional Read-Through in Bacteria: from Synthetic
Networks to Genomic Studies'
- _id: 268BFA92-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03901
name: Cybergenetic circuits to test composability of gene networks
publication: eLife
publication_identifier:
issn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
related_material:
record:
- id: '8951'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Local genetic context shapes the function of a gene regulatory network
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2021'
...
---
_id: '9290'
abstract:
- lang: eng
text: Polar subcellular localization of the PIN exporters of the phytohormone auxin
is a key determinant of directional, intercellular auxin transport and thus a
central topic of both plant cell and developmental biology. Arabidopsis mutants
lacking PID, a kinase that phosphorylates PINs, or the MAB4/MEL proteins of unknown
molecular function display PIN polarity defects and phenocopy pin mutants, but
mechanistic insights into how these factors convey PIN polarity are missing. Here,
by combining protein biochemistry with quantitative live-cell imaging, we demonstrate
that PINs, MAB4/MELs, and AGC kinases interact in the same complex at the plasma
membrane. MAB4/MELs are recruited to the plasma membrane by the PINs and in concert
with the AGC kinases maintain PIN polarity through limiting lateral diffusion-based
escape of PINs from the polar domain. The PIN-MAB4/MEL-PID protein complex has
self-reinforcing properties thanks to positive feedback between AGC kinase-mediated
PIN phosphorylation and MAB4/MEL recruitment. We thus uncover the molecular mechanism
by which AGC kinases and MAB4/MEL proteins regulate PIN localization and plant
development.
acknowledged_ssus:
- _id: Bio
acknowledgement: We acknowledge Ben Scheres, Christian Luschnig, and Claus Schwechheimer
for sharing published material. We thank Monika Hrtyan and Dorota Jaworska at IST
Austria and Gerda Lamers and Ward de Winter at IBL Netherlands for technical assistance;
Corinna Hartinger, Jakub Hajný, Lesia Rodriguez, Mingyue Li, and Lindy Abas for
experimental support; and the Bioimaging Facility at IST Austria and the Bioimaging
Core at VIB for imaging support. We are grateful to Christian Luschnig, Lindy Abas,
and Roman Pleskot for valuable discussions. We also acknowledge the EMBO for supporting
M.G. with a long-term fellowship ( ALTF 1005-2019 ) during the finalization and
revision of this manuscript in the laboratory of B.D.R., and we thank R. Pierik
for allowing K.V.G. to work on this manuscript during a postdoc in his laboratory
at Utrecht University. This work was supported by grants from the European Research
Council under the European Union’s Seventh Framework Programme (ERC grant agreements
742985 to J.F., 714055 to B.D.R., and 803048 to M.F.), the Austrian Science Fund
(FWF; I 3630-B25 to J.F.), Chemical Sciences (partly) financed by the Dutch Research
Council (NWO-CW TOP 700.58.301 to R.O.), the Dutch Research Council (NWO-VICI 865.17.002
to R. Pierik), Grants-in-Aid from the Ministry of Education, Culture, Sports, Science
and Technology, Japan (KAKENHI grant 17K17595 to S.N.), the Ministry of Education,
Youth and Sports of the Czech Republic (MŠMT project NPUI-LO1417 ), and a China
Scholarship Council (to X.W.).
article_processing_charge: No
article_type: original
author:
- first_name: Matous
full_name: Glanc, Matous
id: 1AE1EA24-02D0-11E9-9BAA-DAF4881429F2
last_name: Glanc
orcid: 0000-0003-0619-7783
- first_name: K
full_name: Van Gelderen, K
last_name: Van Gelderen
- first_name: Lukas
full_name: Hörmayer, Lukas
id: 2EEE7A2A-F248-11E8-B48F-1D18A9856A87
last_name: Hörmayer
orcid: 0000-0001-8295-2926
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
- first_name: S
full_name: Naramoto, S
last_name: Naramoto
- first_name: Xixi
full_name: Zhang, Xixi
id: 61A66458-47E9-11EA-85BA-8AEAAF14E49A
last_name: Zhang
orcid: 0000-0001-7048-4627
- first_name: David
full_name: Domjan, David
id: C684CD7A-257E-11EA-9B6F-D8588B4F947F
last_name: Domjan
orcid: 0000-0003-2267-106X
- first_name: L
full_name: Vcelarova, L
last_name: Vcelarova
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Alexander J
full_name: Johnson, Alexander J
id: 46A62C3A-F248-11E8-B48F-1D18A9856A87
last_name: Johnson
orcid: 0000-0002-2739-8843
- first_name: E
full_name: de Koning, E
last_name: de Koning
- first_name: M
full_name: van Dop, M
last_name: van Dop
- first_name: E
full_name: Rademacher, E
last_name: Rademacher
- first_name: S
full_name: Janson, S
last_name: Janson
- first_name: X
full_name: Wei, X
last_name: Wei
- first_name: Gergely
full_name: Molnar, Gergely
id: 34F1AF46-F248-11E8-B48F-1D18A9856A87
last_name: Molnar
- first_name: Matyas
full_name: Fendrych, Matyas
id: 43905548-F248-11E8-B48F-1D18A9856A87
last_name: Fendrych
orcid: 0000-0002-9767-8699
- first_name: B
full_name: De Rybel, B
last_name: De Rybel
- first_name: R
full_name: Offringa, R
last_name: Offringa
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Glanc M, Van Gelderen K, Hörmayer L, et al. AGC kinases and MAB4/MEL proteins
maintain PIN polarity by limiting lateral diffusion in plant cells. Current
Biology. 2021;31(9):1918-1930. doi:10.1016/j.cub.2021.02.028
apa: Glanc, M., Van Gelderen, K., Hörmayer, L., Tan, S., Naramoto, S., Zhang, X.,
… Friml, J. (2021). AGC kinases and MAB4/MEL proteins maintain PIN polarity by
limiting lateral diffusion in plant cells. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2021.02.028
chicago: Glanc, Matous, K Van Gelderen, Lukas Hörmayer, Shutang Tan, S Naramoto,
Xixi Zhang, David Domjan, et al. “AGC Kinases and MAB4/MEL Proteins Maintain PIN
Polarity by Limiting Lateral Diffusion in Plant Cells.” Current Biology.
Elsevier, 2021. https://doi.org/10.1016/j.cub.2021.02.028.
ieee: M. Glanc et al., “AGC kinases and MAB4/MEL proteins maintain PIN polarity
by limiting lateral diffusion in plant cells,” Current Biology, vol. 31,
no. 9. Elsevier, pp. 1918–1930, 2021.
ista: Glanc M, Van Gelderen K, Hörmayer L, Tan S, Naramoto S, Zhang X, Domjan D,
Vcelarova L, Hauschild R, Johnson AJ, de Koning E, van Dop M, Rademacher E, Janson
S, Wei X, Molnar G, Fendrych M, De Rybel B, Offringa R, Friml J. 2021. AGC kinases
and MAB4/MEL proteins maintain PIN polarity by limiting lateral diffusion in plant
cells. Current Biology. 31(9), 1918–1930.
mla: Glanc, Matous, et al. “AGC Kinases and MAB4/MEL Proteins Maintain PIN Polarity
by Limiting Lateral Diffusion in Plant Cells.” Current Biology, vol. 31,
no. 9, Elsevier, 2021, pp. 1918–30, doi:10.1016/j.cub.2021.02.028.
short: M. Glanc, K. Van Gelderen, L. Hörmayer, S. Tan, S. Naramoto, X. Zhang, D.
Domjan, L. Vcelarova, R. Hauschild, A.J. Johnson, E. de Koning, M. van Dop, E.
Rademacher, S. Janson, X. Wei, G. Molnar, M. Fendrych, B. De Rybel, R. Offringa,
J. Friml, Current Biology 31 (2021) 1918–1930.
corr_author: '1'
date_created: 2021-03-26T12:09:33Z
date_published: 2021-03-10T00:00:00Z
date_updated: 2025-04-14T07:45:00Z
day: '10'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1016/j.cub.2021.02.028
ec_funded: 1
external_id:
isi:
- '000653077800004'
pmid:
- '33705718'
file:
- access_level: open_access
checksum: b1723040ecfd8c81194185472eb62546
content_type: application/pdf
creator: dernst
date_created: 2021-04-01T10:53:42Z
date_updated: 2021-04-01T10:53:42Z
file_id: '9303'
file_name: 2021_CurrentBiology_Glanc.pdf
file_size: 4324371
relation: main_file
success: 1
file_date_updated: 2021-04-01T10:53:42Z
has_accepted_license: '1'
intvolume: ' 31'
isi: 1
issue: '9'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 1918-1930
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 26538374-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03630
name: Molecular mechanisms of endocytic cargo recognition in plants
publication: Current Biology
publication_identifier:
eissn:
- 1879-0445
issn:
- 0960-9822
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: AGC kinases and MAB4/MEL proteins maintain PIN polarity by limiting lateral
diffusion in plant cells
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 31
year: '2021'
...
---
_id: '9291'
abstract:
- lang: eng
text: "This .zip File contains the transport data for figures presented in the main
text and supplementary material of \"Enhancement of Proximity Induced Superconductivity
in Planar Germanium\" by K. Aggarwal, et. al. \r\nThe measurements were done using
Labber Software and the data is stored in the hdf5 file format. The files can
be opened using either the Labber Log Browser (https://labber.org/overview/) or
Labber Python API (http://labber.org/online-doc/api/LogFile.html)."
article_processing_charge: No
author:
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
citation:
ama: 'Katsaros G. Raw transport data for: Enhancement of proximity induced superconductivity
in planar germanium. 2021. doi:10.15479/AT:ISTA:9291'
apa: 'Katsaros, G. (2021). Raw transport data for: Enhancement of proximity induced
superconductivity in planar germanium. Institute of Science and Technology Austria.
https://doi.org/10.15479/AT:ISTA:9291'
chicago: 'Katsaros, Georgios. “Raw Transport Data for: Enhancement of Proximity
Induced Superconductivity in Planar Germanium.” Institute of Science and Technology
Austria, 2021. https://doi.org/10.15479/AT:ISTA:9291.'
ieee: 'G. Katsaros, “Raw transport data for: Enhancement of proximity induced superconductivity
in planar germanium.” Institute of Science and Technology Austria, 2021.'
ista: 'Katsaros G. 2021. Raw transport data for: Enhancement of proximity induced
superconductivity in planar germanium, Institute of Science and Technology Austria,
10.15479/AT:ISTA:9291.'
mla: 'Katsaros, Georgios. Raw Transport Data for: Enhancement of Proximity Induced
Superconductivity in Planar Germanium. Institute of Science and Technology
Austria, 2021, doi:10.15479/AT:ISTA:9291.'
short: G. Katsaros, (2021).
date_created: 2021-03-27T13:47:49Z
date_published: 2021-03-29T00:00:00Z
date_updated: 2024-02-21T12:37:14Z
day: '29'
ddc:
- '530'
department:
- _id: GeKa
doi: 10.15479/AT:ISTA:9291
file:
- access_level: open_access
checksum: 635df3c08fc13c3dac008cd421aefbe4
content_type: application/x-zip-compressed
creator: gkatsaro
date_created: 2021-03-27T13:46:17Z
date_updated: 2021-03-27T13:46:17Z
file_id: '9292'
file_name: Raw Data- Enhancement of Superconductivity in a Planar Ge hole gas.zip
file_size: 10616071
relation: main_file
success: 1
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checksum: 12b3ca69ae7509a346711baae0b02a75
content_type: text/plain
creator: dernst
date_created: 2021-04-01T07:52:56Z
date_updated: 2021-04-01T07:52:56Z
file_id: '9302'
file_name: README.txt
file_size: 470
relation: main_file
success: 1
file_date_updated: 2021-04-01T07:52:56Z
has_accepted_license: '1'
license: https://creativecommons.org/publicdomain/zero/1.0/
month: '03'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
status: public
title: 'Raw transport data for: Enhancement of proximity induced superconductivity
in planar germanium'
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '9293'
abstract:
- lang: eng
text: 'We consider planning problems for graphs, Markov Decision Processes (MDPs),
and games on graphs in an explicit state space. While graphs represent the most
basic planning model, MDPs represent interaction with nature and games on graphs
represent interaction with an adversarial environment. We consider two planning
problems with k different target sets: (a) the coverage problem asks whether there
is a plan for each individual target set; and (b) the sequential target reachability
problem asks whether the targets can be reached in a given sequence. For the coverage
problem, we present a linear-time algorithm for graphs, and quadratic conditional
lower bound for MDPs and games on graphs. For the sequential target problem, we
present a linear-time algorithm for graphs, a sub-quadratic algorithm for MDPs,
and a quadratic conditional lower bound for games on graphs. Our results with
conditional lower bounds, based on the boolean matrix multiplication (BMM) conjecture
and strong exponential time hypothesis (SETH), establish (i) model-separation
results showing that for the coverage problem MDPs and games on graphs are harder
than graphs, and for the sequential reachability problem games on graphs are harder
than MDPs and graphs; and (ii) problem-separation results showing that for MDPs
the coverage problem is harder than the sequential target problem.'
article_number: '103499'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Wolfgang
full_name: Dvořák, Wolfgang
last_name: Dvořák
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Alexander
full_name: Svozil, Alexander
last_name: Svozil
citation:
ama: Chatterjee K, Dvořák W, Henzinger M, Svozil A. Algorithms and conditional lower
bounds for planning problems. Artificial Intelligence. 2021;297(8). doi:10.1016/j.artint.2021.103499
apa: Chatterjee, K., Dvořák, W., Henzinger, M., & Svozil, A. (2021). Algorithms
and conditional lower bounds for planning problems. Artificial Intelligence.
Elsevier. https://doi.org/10.1016/j.artint.2021.103499
chicago: Chatterjee, Krishnendu, Wolfgang Dvořák, Monika Henzinger, and Alexander
Svozil. “Algorithms and Conditional Lower Bounds for Planning Problems.” Artificial
Intelligence. Elsevier, 2021. https://doi.org/10.1016/j.artint.2021.103499.
ieee: K. Chatterjee, W. Dvořák, M. Henzinger, and A. Svozil, “Algorithms and conditional
lower bounds for planning problems,” Artificial Intelligence, vol. 297,
no. 8. Elsevier, 2021.
ista: Chatterjee K, Dvořák W, Henzinger M, Svozil A. 2021. Algorithms and conditional
lower bounds for planning problems. Artificial Intelligence. 297(8), 103499.
mla: Chatterjee, Krishnendu, et al. “Algorithms and Conditional Lower Bounds for
Planning Problems.” Artificial Intelligence, vol. 297, no. 8, 103499, Elsevier,
2021, doi:10.1016/j.artint.2021.103499.
short: K. Chatterjee, W. Dvořák, M. Henzinger, A. Svozil, Artificial Intelligence
297 (2021).
corr_author: '1'
date_created: 2021-03-28T22:01:40Z
date_published: 2021-03-16T00:00:00Z
date_updated: 2025-07-10T11:52:31Z
day: '16'
department:
- _id: KrCh
doi: 10.1016/j.artint.2021.103499
external_id:
arxiv:
- '1804.07031'
isi:
- '000657537500003'
intvolume: ' 297'
isi: 1
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1804.07031
month: '03'
oa: 1
oa_version: Preprint
publication: Artificial Intelligence
publication_identifier:
issn:
- 0004-3702
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '35'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Algorithms and conditional lower bounds for planning problems
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 297
year: '2021'
...
---
_id: '9295'
abstract:
- lang: eng
text: "Hill's Conjecture states that the crossing number cr(\U0001D43E\U0001D45B)
\ of the complete graph \U0001D43E\U0001D45B in the plane (equivalently, the
sphere) is 14⌊\U0001D45B2⌋⌊\U0001D45B−12⌋⌊\U0001D45B−22⌋⌊\U0001D45B−32⌋=\U0001D45B4/64+\U0001D442(\U0001D45B3)
. Moon proved that the expected number of crossings in a spherical drawing in
which the points are randomly distributed and joined by geodesics is precisely
\ \U0001D45B4/64+\U0001D442(\U0001D45B3) , thus matching asymptotically the conjectured
value of cr(\U0001D43E\U0001D45B) . Let cr\U0001D443(\U0001D43A) denote the
crossing number of a graph \U0001D43A in the projective plane. Recently, Elkies
proved that the expected number of crossings in a naturally defined random projective
plane drawing of \U0001D43E\U0001D45B is (\U0001D45B4/8\U0001D70B2)+\U0001D442(\U0001D45B3)
. In analogy with the relation of Moon's result to Hill's conjecture, Elkies asked
if lim\U0001D45B→∞ cr\U0001D443(\U0001D43E\U0001D45B)/\U0001D45B4=1/8\U0001D70B2
. We construct drawings of \U0001D43E\U0001D45B in the projective plane that
disprove this."
acknowledgement: "We thank two reviewers for their corrections and suggestions on
the original version of this\r\npaper. This project has received funding from NSERC
Grant 50503-10940-500 and from the European Union’s Horizon 2020 research and innovation
programme under the Marie SkłodowskaCurie grant agreement No 754411, IST, Klosterneuburg,
Austria."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Alan M
full_name: Arroyo Guevara, Alan M
id: 3207FDC6-F248-11E8-B48F-1D18A9856A87
last_name: Arroyo Guevara
orcid: 0000-0003-2401-8670
- first_name: Dan
full_name: Mcquillan, Dan
last_name: Mcquillan
- first_name: R. Bruce
full_name: Richter, R. Bruce
last_name: Richter
- first_name: Gelasio
full_name: Salazar, Gelasio
last_name: Salazar
- first_name: Matthew
full_name: Sullivan, Matthew
last_name: Sullivan
citation:
ama: Arroyo Guevara AM, Mcquillan D, Richter RB, Salazar G, Sullivan M. Drawings
of complete graphs in the projective plane. Journal of Graph Theory. 2021;97(3):426-440.
doi:10.1002/jgt.22665
apa: Arroyo Guevara, A. M., Mcquillan, D., Richter, R. B., Salazar, G., & Sullivan,
M. (2021). Drawings of complete graphs in the projective plane. Journal of
Graph Theory. Wiley. https://doi.org/10.1002/jgt.22665
chicago: Arroyo Guevara, Alan M, Dan Mcquillan, R. Bruce Richter, Gelasio Salazar,
and Matthew Sullivan. “Drawings of Complete Graphs in the Projective Plane.” Journal
of Graph Theory. Wiley, 2021. https://doi.org/10.1002/jgt.22665.
ieee: A. M. Arroyo Guevara, D. Mcquillan, R. B. Richter, G. Salazar, and M. Sullivan,
“Drawings of complete graphs in the projective plane,” Journal of Graph Theory,
vol. 97, no. 3. Wiley, pp. 426–440, 2021.
ista: Arroyo Guevara AM, Mcquillan D, Richter RB, Salazar G, Sullivan M. 2021. Drawings
of complete graphs in the projective plane. Journal of Graph Theory. 97(3), 426–440.
mla: Arroyo Guevara, Alan M., et al. “Drawings of Complete Graphs in the Projective
Plane.” Journal of Graph Theory, vol. 97, no. 3, Wiley, 2021, pp. 426–40,
doi:10.1002/jgt.22665.
short: A.M. Arroyo Guevara, D. Mcquillan, R.B. Richter, G. Salazar, M. Sullivan,
Journal of Graph Theory 97 (2021) 426–440.
date_created: 2021-03-28T22:01:41Z
date_published: 2021-03-23T00:00:00Z
date_updated: 2025-04-14T07:43:51Z
day: '23'
department:
- _id: UlWa
doi: 10.1002/jgt.22665
ec_funded: 1
external_id:
arxiv:
- '2002.02287'
isi:
- '000631693200001'
intvolume: ' 97'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2002.02287
month: '03'
oa: 1
oa_version: Preprint
page: 426-440
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Journal of Graph Theory
publication_identifier:
eissn:
- 1097-0118
issn:
- 0364-9024
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Drawings of complete graphs in the projective plane
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 97
year: '2021'
...
---
_id: '9297'
abstract:
- lang: eng
text: 'We report the results of an experimental investigation into the decay of
turbulence in plane Couette–Poiseuille flow using ‘quench’ experiments where the
flow laminarises after a sudden reduction in Reynolds number Re. Specifically,
we study the velocity field in the streamwise–spanwise plane. We show that the
spanwise velocity containing rolls decays faster than the streamwise velocity,
which displays elongated regions of higher or lower velocity called streaks. At
final Reynolds numbers above 425, the decay of streaks displays two stages: first
a slow decay when rolls are present and secondly a more rapid decay of streaks
alone. The difference in behaviour results from the regeneration of streaks by
rolls, called the lift-up effect. We define the turbulent fraction as the portion
of the flow containing turbulence and this is estimated by thresholding the spanwise
velocity component. It decreases linearly with time in the whole range of final
Re. The corresponding decay slope increases linearly with final Re. The extrapolated
value at which this decay slope vanishes is Reaz≈656±10, close to Reg≈670 at which
turbulence is self-sustained. The decay of the energy computed from the spanwise
velocity component is found to be exponential. The corresponding decay rate increases
linearly with Re, with an extrapolated vanishing value at ReAz≈688±10. This value
is also close to the value at which the turbulence is self-sustained, showing
that valuable information on the transition can be obtained over a wide range
of Re.'
acknowledgement: "We gratefully acknowledge Joran Rolland, Yohann Duguet, Romain Monchaux,
S´ebastien Gom´e, Laurette Tuckerman, Dwight Barkley, Olivier Dauchot and Sabine
Bottin for fruitful discussions. We thank Xavier Benoit-Gonin, Amaury Fourgeaud,
Thierry Darnige, Olivier Brouard and Justine Laurent for technical help. This work
has benefited from the ANR TransFlow, and by starting grants obtained by B.S. from
CNRS (INSIS) and ESPCI. T.M. was\r\nsupported by a Joliot visiting professorship
grant from ESPCI."
article_number: A65
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: T.
full_name: Liu, T.
last_name: Liu
- first_name: B.
full_name: Semin, B.
last_name: Semin
- first_name: Lukasz
full_name: Klotz, Lukasz
id: 2C9AF1C2-F248-11E8-B48F-1D18A9856A87
last_name: Klotz
orcid: 0000-0003-1740-7635
- first_name: R.
full_name: Godoy-Diana, R.
last_name: Godoy-Diana
- first_name: J. E.
full_name: Wesfreid, J. E.
last_name: Wesfreid
- first_name: T.
full_name: Mullin, T.
last_name: Mullin
citation:
ama: Liu T, Semin B, Klotz L, Godoy-Diana R, Wesfreid JE, Mullin T. Decay of streaks
and rolls in plane Couette-Poiseuille flow. Journal of Fluid Mechanics.
2021;915. doi:10.1017/jfm.2021.89
apa: Liu, T., Semin, B., Klotz, L., Godoy-Diana, R., Wesfreid, J. E., & Mullin,
T. (2021). Decay of streaks and rolls in plane Couette-Poiseuille flow. Journal
of Fluid Mechanics. Cambridge University Press. https://doi.org/10.1017/jfm.2021.89
chicago: Liu, T., B. Semin, Lukasz Klotz, R. Godoy-Diana, J. E. Wesfreid, and T.
Mullin. “Decay of Streaks and Rolls in Plane Couette-Poiseuille Flow.” Journal
of Fluid Mechanics. Cambridge University Press, 2021. https://doi.org/10.1017/jfm.2021.89.
ieee: T. Liu, B. Semin, L. Klotz, R. Godoy-Diana, J. E. Wesfreid, and T. Mullin,
“Decay of streaks and rolls in plane Couette-Poiseuille flow,” Journal of Fluid
Mechanics, vol. 915. Cambridge University Press, 2021.
ista: Liu T, Semin B, Klotz L, Godoy-Diana R, Wesfreid JE, Mullin T. 2021. Decay
of streaks and rolls in plane Couette-Poiseuille flow. Journal of Fluid Mechanics.
915, A65.
mla: Liu, T., et al. “Decay of Streaks and Rolls in Plane Couette-Poiseuille Flow.”
Journal of Fluid Mechanics, vol. 915, A65, Cambridge University Press,
2021, doi:10.1017/jfm.2021.89.
short: T. Liu, B. Semin, L. Klotz, R. Godoy-Diana, J.E. Wesfreid, T. Mullin, Journal
of Fluid Mechanics 915 (2021).
date_created: 2021-03-28T22:01:42Z
date_published: 2021-03-17T00:00:00Z
date_updated: 2023-08-07T14:30:11Z
day: '17'
department:
- _id: BjHo
doi: 10.1017/jfm.2021.89
external_id:
arxiv:
- '2008.08851'
isi:
- '000629677500001'
intvolume: ' 915'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2008.08851
month: '03'
oa: 1
oa_version: Preprint
publication: Journal of Fluid Mechanics
publication_identifier:
eissn:
- 1469-7645
issn:
- 0022-1120
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Decay of streaks and rolls in plane Couette-Poiseuille flow
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 915
year: '2021'
...
---
_id: '9301'
abstract:
- lang: eng
text: Electrodepositing insulating lithium peroxide (Li2O2) is the key process during
discharge of aprotic Li–O2 batteries and determines rate, capacity, and reversibility.
Current understanding states that the partition between surface adsorbed and dissolved
lithium superoxide governs whether Li2O2 grows as a conformal surface film or
larger particles, leading to low or high capacities, respectively. However, better
understanding governing factors for Li2O2 packing density and capacity requires
structural sensitive in situ metrologies. Here, we establish in situ small- and
wide-angle X-ray scattering (SAXS/WAXS) as a suitable method to record the Li2O2
phase evolution with atomic to submicrometer resolution during cycling a custom-built
in situ Li–O2 cell. Combined with sophisticated data analysis, SAXS allows retrieving
rich quantitative structural information from complex multiphase systems. Surprisingly,
we find that features are absent that would point at a Li2O2 surface film formed
via two consecutive electron transfers, even in poorly solvating electrolytes
thought to be prototypical for surface growth. All scattering data can be modeled
by stacks of thin Li2O2 platelets potentially forming large toroidal particles.
Li2O2 solution growth is further justified by rotating ring-disk electrode measurements
and electron microscopy. Higher discharge overpotentials lead to smaller Li2O2
particles, but there is no transition to an electronically passivating, conformal
Li2O2 coating. Hence, mass transport of reactive species rather than electronic
transport through a Li2O2 film limits the discharge capacity. Provided that species
mobilities and carbon surface areas are high, this allows for high discharge capacities
even in weakly solvating electrolytes. The currently accepted Li–O2 reaction mechanism
ought to be reconsidered.
acknowledged_ssus:
- _id: EM-Fac
acknowledgement: S.A.F. and C.P. are indebted to the European Research Council under
the European Union's Horizon 2020 research and innovation program (Grant Agreement
No. 636069), the Austrian Federal Ministry of Science, Research and Economy, and
the Austrian Research Promotion Agency (Grant No. 845364). We acknowledge A. Zankel
and H. Schroettner for support with SEM measurements. C.P. thanks N. Kostoglou,
C. Koczwara, M. Hartmann, and M. Burian for discussions on gas sorption analysis,
C++ programming, Monte Carlo modeling, and in situ SAXS experiments, respectively.
We thank S. Stadlbauer for help with Karl Fischer titration, R. Riccò for gas sorption
measurements, and acknowledge Graz University of Technology for support through
the Lead Project LP-03. Likewise, the use of SOMAPP Lab, a core facility supported
by the Austrian Federal Ministry of Education, Science and Research, the Graz University
of Technology, the University of Graz, and Anton Paar GmbH is acknowledged. S.A.F.
is indebted to Institute of Science and Technology Austria (IST Austria) for support.
This research was supported by the Scientific Service Units of IST Austria through
resources provided by the Electron Microscopy Facility.
article_number: e2021893118
article_processing_charge: No
article_type: original
author:
- first_name: Christian
full_name: Prehal, Christian
last_name: Prehal
- first_name: Aleksej
full_name: Samojlov, Aleksej
last_name: Samojlov
- first_name: Manfred
full_name: Nachtnebel, Manfred
last_name: Nachtnebel
- first_name: Ludek
full_name: Lovicar, Ludek
id: 36DB3A20-F248-11E8-B48F-1D18A9856A87
last_name: Lovicar
orcid: 0000-0001-6206-4200
- first_name: Manfred
full_name: Kriechbaum, Manfred
last_name: Kriechbaum
- first_name: Heinz
full_name: Amenitsch, Heinz
last_name: Amenitsch
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
citation:
ama: Prehal C, Samojlov A, Nachtnebel M, et al. In situ small-angle X-ray scattering
reveals solution phase discharge of Li–O2 batteries with weakly solvating electrolytes.
Proceedings of the National Academy of Sciences of the United States of America.
2021;118(14). doi:10.1073/pnas.2021893118
apa: Prehal, C., Samojlov, A., Nachtnebel, M., Lovicar, L., Kriechbaum, M., Amenitsch,
H., & Freunberger, S. A. (2021). In situ small-angle X-ray scattering reveals
solution phase discharge of Li–O2 batteries with weakly solvating electrolytes.
Proceedings of the National Academy of Sciences of the United States of America.
National Academy of Sciences. https://doi.org/10.1073/pnas.2021893118
chicago: Prehal, Christian, Aleksej Samojlov, Manfred Nachtnebel, Ludek Lovicar,
Manfred Kriechbaum, Heinz Amenitsch, and Stefan Alexander Freunberger. “In Situ
Small-Angle X-Ray Scattering Reveals Solution Phase Discharge of Li–O2 Batteries
with Weakly Solvating Electrolytes.” Proceedings of the National Academy of
Sciences of the United States of America. National Academy of Sciences, 2021.
https://doi.org/10.1073/pnas.2021893118.
ieee: C. Prehal et al., “In situ small-angle X-ray scattering reveals solution
phase discharge of Li–O2 batteries with weakly solvating electrolytes,” Proceedings
of the National Academy of Sciences of the United States of America, vol.
118, no. 14. National Academy of Sciences, 2021.
ista: Prehal C, Samojlov A, Nachtnebel M, Lovicar L, Kriechbaum M, Amenitsch H,
Freunberger SA. 2021. In situ small-angle X-ray scattering reveals solution phase
discharge of Li–O2 batteries with weakly solvating electrolytes. Proceedings of
the National Academy of Sciences of the United States of America. 118(14), e2021893118.
mla: Prehal, Christian, et al. “In Situ Small-Angle X-Ray Scattering Reveals Solution
Phase Discharge of Li–O2 Batteries with Weakly Solvating Electrolytes.” Proceedings
of the National Academy of Sciences of the United States of America, vol.
118, no. 14, e2021893118, National Academy of Sciences, 2021, doi:10.1073/pnas.2021893118.
short: C. Prehal, A. Samojlov, M. Nachtnebel, L. Lovicar, M. Kriechbaum, H. Amenitsch,
S.A. Freunberger, Proceedings of the National Academy of Sciences of the United
States of America 118 (2021).
date_created: 2021-03-31T07:00:01Z
date_published: 2021-04-06T00:00:00Z
date_updated: 2025-06-12T06:56:39Z
day: '06'
department:
- _id: StFr
- _id: EM-Fac
doi: 10.1073/pnas.2021893118
external_id:
isi:
- '000637398300050'
pmid:
- '33785597'
intvolume: ' 118'
isi: 1
issue: '14'
keyword:
- small-angle X-ray scattering
- oxygen reduction
- disproportionation
- Li-air battery
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.26434/chemrxiv.11447775
month: '04'
oa: 1
oa_version: Preprint
pmid: 1
publication: Proceedings of the National Academy of Sciences of the United States
of America
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: In situ small-angle X-ray scattering reveals solution phase discharge of Li–O2
batteries with weakly solvating electrolytes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 118
year: '2021'
...
---
_id: '9304'
abstract:
- lang: eng
text: The high processing cost, poor mechanical properties and moderate performance
of Bi2Te3–based alloys used in thermoelectric devices limit the cost-effectiveness
of this energy conversion technology. Towards solving these current challenges,
in the present work, we detail a low temperature solution-based approach to produce
Bi2Te3-Cu2-xTe nanocomposites with improved thermoelectric performance. Our approach
consists in combining proper ratios of colloidal nanoparticles and to consolidate
the resulting mixture into nanocomposites using a hot press. The transport properties
of the nanocomposites are characterized and compared with those of pure Bi2Te3
nanomaterials obtained following the same procedure. In contrast with most previous
works, the presence of Cu2-xTe nanodomains does not result in a significant reduction
of the lattice thermal conductivity of the reference Bi2Te3 nanomaterial, which
is already very low. However, the introduction of Cu2-xTe yields a nearly threefold
increase of the power factor associated to a simultaneous increase of the Seebeck
coefficient and electrical conductivity at temperatures above 400 K. Taking into
account the band alignment of the two materials, we rationalize this increase
by considering that Cu2-xTe nanostructures, with a relatively low electron affinity,
are able to inject electrons into Bi2Te3, enhancing in this way its electrical
conductivity. The simultaneous increase of the Seebeck coefficient is related
to the energy filtering of charge carriers at energy barriers within Bi2Te3 domains
associated with the accumulation of electrons in regions nearby a Cu2-xTe/Bi2Te3
heterojunction. Overall, with the incorporation of a proper amount of Cu2-xTe
nanoparticles, we demonstrate a 250% improvement of the thermoelectric figure
of merit of Bi2Te3.
acknowledgement: "This work was supported by the European Regional Development Funds
and by the Generalitat de Catalunya through the project 2017SGR1246. Y.Z, C.X, M.L,
K.X and X.H thank the China Scholarship Council for the scholarship support. MI
acknowledges financial support from IST Austria. YL acknowledges funding from the
European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie
grant agreement No. 754411. ICN2\r\nacknowledges funding from Generalitat de Catalunya
2017 SGR 327 and the Spanish MINECO project ENE2017-85087-C3. ICN2 is supported
by the Severo Ochoa program from the Spanish MINECO (grant no. SEV-2017-0706) and
is funded by the CERCA Program/Generalitat de Catalunya. Part of the present work
has been performed in the framework of Universitat Autònoma de Barcelona Materials
Science PhD program."
article_number: '129374'
article_processing_charge: No
article_type: original
author:
- first_name: Yu
full_name: Zhang, Yu
last_name: Zhang
- first_name: Congcong
full_name: Xing, Congcong
last_name: Xing
- first_name: Yu
full_name: Liu, Yu
id: 2A70014E-F248-11E8-B48F-1D18A9856A87
last_name: Liu
orcid: 0000-0001-7313-6740
- first_name: Mengyao
full_name: Li, Mengyao
last_name: Li
- first_name: Ke
full_name: Xiao, Ke
last_name: Xiao
- first_name: Pablo
full_name: Guardia, Pablo
last_name: Guardia
- first_name: Seungho
full_name: Lee, Seungho
id: BB243B88-D767-11E9-B658-BC13E6697425
last_name: Lee
orcid: 0000-0002-6962-8598
- first_name: Xu
full_name: Han, Xu
last_name: Han
- first_name: Ahmad
full_name: Moghaddam, Ahmad
last_name: Moghaddam
- first_name: Joan J
full_name: Roa, Joan J
last_name: Roa
- first_name: Jordi
full_name: Arbiol, Jordi
last_name: Arbiol
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
- first_name: Kai
full_name: Pan, Kai
last_name: Pan
- first_name: Mirko
full_name: Prato, Mirko
last_name: Prato
- first_name: Ying
full_name: Xie, Ying
last_name: Xie
- first_name: Andreu
full_name: Cabot, Andreu
last_name: Cabot
citation:
ama: Zhang Y, Xing C, Liu Y, et al. Influence of copper telluride nanodomains on
the transport properties of n-type bismuth telluride. Chemical Engineering
Journal. 2021;418(8). doi:10.1016/j.cej.2021.129374
apa: Zhang, Y., Xing, C., Liu, Y., Li, M., Xiao, K., Guardia, P., … Cabot, A. (2021).
Influence of copper telluride nanodomains on the transport properties of n-type
bismuth telluride. Chemical Engineering Journal. Elsevier. https://doi.org/10.1016/j.cej.2021.129374
chicago: Zhang, Yu, Congcong Xing, Yu Liu, Mengyao Li, Ke Xiao, Pablo Guardia, Seungho
Lee, et al. “Influence of Copper Telluride Nanodomains on the Transport Properties
of N-Type Bismuth Telluride.” Chemical Engineering Journal. Elsevier, 2021.
https://doi.org/10.1016/j.cej.2021.129374.
ieee: Y. Zhang et al., “Influence of copper telluride nanodomains on the
transport properties of n-type bismuth telluride,” Chemical Engineering Journal,
vol. 418, no. 8. Elsevier, 2021.
ista: Zhang Y, Xing C, Liu Y, Li M, Xiao K, Guardia P, Lee S, Han X, Moghaddam A,
Roa JJ, Arbiol J, Ibáñez M, Pan K, Prato M, Xie Y, Cabot A. 2021. Influence of
copper telluride nanodomains on the transport properties of n-type bismuth telluride.
Chemical Engineering Journal. 418(8), 129374.
mla: Zhang, Yu, et al. “Influence of Copper Telluride Nanodomains on the Transport
Properties of N-Type Bismuth Telluride.” Chemical Engineering Journal,
vol. 418, no. 8, 129374, Elsevier, 2021, doi:10.1016/j.cej.2021.129374.
short: Y. Zhang, C. Xing, Y. Liu, M. Li, K. Xiao, P. Guardia, S. Lee, X. Han, A.
Moghaddam, J.J. Roa, J. Arbiol, M. Ibáñez, K. Pan, M. Prato, Y. Xie, A. Cabot,
Chemical Engineering Journal 418 (2021).
date_created: 2021-04-04T22:01:20Z
date_published: 2021-08-15T00:00:00Z
date_updated: 2025-04-14T07:43:52Z
day: '15'
department:
- _id: MaIb
doi: 10.1016/j.cej.2021.129374
ec_funded: 1
external_id:
isi:
- '000655672000005'
intvolume: ' 418'
isi: 1
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://ddd.uab.cat/record/271949
month: '08'
oa: 1
oa_version: Submitted Version
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Chemical Engineering Journal
publication_identifier:
issn:
- 1385-8947
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Influence of copper telluride nanodomains on the transport properties of n-type
bismuth telluride
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 418
year: '2021'
...
---
_id: '9305'
abstract:
- lang: eng
text: Copper chalcogenides are outstanding thermoelectric materials for applications
in the medium-high temperature range. Among different chalcogenides, while Cu2−xSe
is characterized by higher thermoelectric figures of merit, Cu2−xS provides advantages
in terms of low cost and element abundance. In the present work, we investigate
the effect of different dopants to enhance the Cu2−xS performance and also its
thermal stability. Among the tested options, Pb-doped Cu2−xS shows the highest
improvement in stability against sulfur volatilization. Additionally, Pb incorporation
allows tuning charge carrier concentration, which enables a significant improvement
of the power factor. We demonstrate here that the introduction of an optimal additive
amount of just 0.3% results in a threefold increase of the power factor in the
middle-temperature range (500–800 K) and a record dimensionless thermoelectric
figure of merit above 2 at 880 K.
acknowledgement: This work was supported by the European Regional Development Fund
and by the Spanish Ministerio de Economía y Competitividad through the project SEHTOP
(ENE2016-77798-C4-3-R). MI acknowledges financial support from IST Austria. YL acknowledges
funding from the European Union’s Horizon 2020 research and innovation program under
the Marie Sklodowska-Curie grant agreement No. 754411. YZ, CX, XW, KX and TZ thank
the China Scholarship Council for the scholarship support. ICN2 acknowledges funding
from Generalitat de Catalunya 2017 SGR 327 and the Spanish MINECO project ENE2017-85087-C3.
ICN2 is supported by the Severo Ochoa program from the Spanish MINECO (grant no.
SEV-2017-0706) and is funded by the CERCA program/Generalitat de Catalunya. Part
of the present work has been performed in the framework of Universitat Autònoma
de Barcelona Materials Science Ph.D. program. M.C.S. has received funding from the
European Union’s Horizon 2020 research and innovation programme under the Marie
Skłodowska-Curie grant agreement No. 754510 (PROBIST) and the Severo Ochoa programme.
P.G. acknowledges financial support from the Spanish government (MICIU) through
the RTI2018-102006-J-I00 project and the Catalan Agency of Competitiveness (ACCIO)
through the TecnioSpring+ Marie Sklodowska-Curie action TECSPR16-1-0082. YZ and
CX contributed equally to this work.
article_number: '105991'
article_processing_charge: No
article_type: original
author:
- first_name: Yu
full_name: Zhang, Yu
last_name: Zhang
- first_name: Congcong
full_name: Xing, Congcong
last_name: Xing
- first_name: Yu
full_name: Liu, Yu
id: 2A70014E-F248-11E8-B48F-1D18A9856A87
last_name: Liu
orcid: 0000-0001-7313-6740
- first_name: Maria Chiara
full_name: Spadaro, Maria Chiara
last_name: Spadaro
- first_name: Xiang
full_name: Wang, Xiang
last_name: Wang
- first_name: Mengyao
full_name: Li, Mengyao
last_name: Li
- first_name: Ke
full_name: Xiao, Ke
last_name: Xiao
- first_name: Ting
full_name: Zhang, Ting
last_name: Zhang
- first_name: Pablo
full_name: Guardia, Pablo
last_name: Guardia
- first_name: Khak Ho
full_name: Lim, Khak Ho
last_name: Lim
- first_name: Ahmad Ostovari
full_name: Moghaddam, Ahmad Ostovari
last_name: Moghaddam
- first_name: Jordi
full_name: Llorca, Jordi
last_name: Llorca
- first_name: Jordi
full_name: Arbiol, Jordi
last_name: Arbiol
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
- first_name: Andreu
full_name: Cabot, Andreu
last_name: Cabot
citation:
ama: Zhang Y, Xing C, Liu Y, et al. Doping-mediated stabilization of copper vacancies
to promote thermoelectric properties of Cu2-xS. Nano Energy. 2021;85(7).
doi:10.1016/j.nanoen.2021.105991
apa: Zhang, Y., Xing, C., Liu, Y., Spadaro, M. C., Wang, X., Li, M., … Cabot, A.
(2021). Doping-mediated stabilization of copper vacancies to promote thermoelectric
properties of Cu2-xS. Nano Energy. Elsevier. https://doi.org/10.1016/j.nanoen.2021.105991
chicago: Zhang, Yu, Congcong Xing, Yu Liu, Maria Chiara Spadaro, Xiang Wang, Mengyao
Li, Ke Xiao, et al. “Doping-Mediated Stabilization of Copper Vacancies to Promote
Thermoelectric Properties of Cu2-XS.” Nano Energy. Elsevier, 2021. https://doi.org/10.1016/j.nanoen.2021.105991.
ieee: Y. Zhang et al., “Doping-mediated stabilization of copper vacancies
to promote thermoelectric properties of Cu2-xS,” Nano Energy, vol. 85,
no. 7. Elsevier, 2021.
ista: Zhang Y, Xing C, Liu Y, Spadaro MC, Wang X, Li M, Xiao K, Zhang T, Guardia
P, Lim KH, Moghaddam AO, Llorca J, Arbiol J, Ibáñez M, Cabot A. 2021. Doping-mediated
stabilization of copper vacancies to promote thermoelectric properties of Cu2-xS.
Nano Energy. 85(7), 105991.
mla: Zhang, Yu, et al. “Doping-Mediated Stabilization of Copper Vacancies to Promote
Thermoelectric Properties of Cu2-XS.” Nano Energy, vol. 85, no. 7, 105991,
Elsevier, 2021, doi:10.1016/j.nanoen.2021.105991.
short: Y. Zhang, C. Xing, Y. Liu, M.C. Spadaro, X. Wang, M. Li, K. Xiao, T. Zhang,
P. Guardia, K.H. Lim, A.O. Moghaddam, J. Llorca, J. Arbiol, M. Ibáñez, A. Cabot,
Nano Energy 85 (2021).
corr_author: '1'
date_created: 2021-04-04T22:01:21Z
date_published: 2021-07-01T00:00:00Z
date_updated: 2025-04-14T07:43:52Z
day: '01'
department:
- _id: MaIb
doi: 10.1016/j.nanoen.2021.105991
ec_funded: 1
external_id:
isi:
- '000663442200004'
intvolume: ' 85'
isi: 1
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://ddd.uab.cat/record/271947
month: '07'
oa: 1
oa_version: Submitted Version
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Nano Energy
publication_identifier:
issn:
- 2211-2855
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Doping-mediated stabilization of copper vacancies to promote thermoelectric
properties of Cu2-xS
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 85
year: '2021'
...
---
_id: '9307'
abstract:
- lang: eng
text: We establish finite time extinction with probability one for weak solutions
of the Cauchy–Dirichlet problem for the 1D stochastic porous medium equation with
Stratonovich transport noise and compactly supported smooth initial datum. Heuristically,
this is expected to hold because Brownian motion has average spread rate O(t12)
whereas the support of solutions to the deterministic PME grows only with rate
O(t1m+1). The rigorous proof relies on a contraction principle up to time-dependent
shift for Wong–Zakai type approximations, the transformation to a deterministic
PME with two copies of a Brownian path as the lateral boundary, and techniques
from the theory of viscosity solutions.
acknowledgement: This project has received funding from the European Union’s Horizon
2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement
No. 665385 . I am very grateful to M. Gerencsér and J. Maas for proposing this problem
as well as helpful discussions. Special thanks go to F. Cornalba for suggesting
the additional κ-truncation in Proposition 5. I am also indebted to an anonymous
referee for pointing out a gap in a previous version of the proof of Lemma 9 (concerning
the treatment of the noise term). The issue is resolved in this version.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Sebastian
full_name: Hensel, Sebastian
id: 4D23B7DA-F248-11E8-B48F-1D18A9856A87
last_name: Hensel
orcid: 0000-0001-7252-8072
citation:
ama: 'Hensel S. Finite time extinction for the 1D stochastic porous medium equation
with transport noise. Stochastics and Partial Differential Equations: Analysis
and Computations. 2021;9:892–939. doi:10.1007/s40072-021-00188-9'
apa: 'Hensel, S. (2021). Finite time extinction for the 1D stochastic porous medium
equation with transport noise. Stochastics and Partial Differential Equations:
Analysis and Computations. Springer Nature. https://doi.org/10.1007/s40072-021-00188-9'
chicago: 'Hensel, Sebastian. “Finite Time Extinction for the 1D Stochastic Porous
Medium Equation with Transport Noise.” Stochastics and Partial Differential
Equations: Analysis and Computations. Springer Nature, 2021. https://doi.org/10.1007/s40072-021-00188-9.'
ieee: 'S. Hensel, “Finite time extinction for the 1D stochastic porous medium equation
with transport noise,” Stochastics and Partial Differential Equations: Analysis
and Computations, vol. 9. Springer Nature, pp. 892–939, 2021.'
ista: 'Hensel S. 2021. Finite time extinction for the 1D stochastic porous medium
equation with transport noise. Stochastics and Partial Differential Equations:
Analysis and Computations. 9, 892–939.'
mla: 'Hensel, Sebastian. “Finite Time Extinction for the 1D Stochastic Porous Medium
Equation with Transport Noise.” Stochastics and Partial Differential Equations:
Analysis and Computations, vol. 9, Springer Nature, 2021, pp. 892–939, doi:10.1007/s40072-021-00188-9.'
short: 'S. Hensel, Stochastics and Partial Differential Equations: Analysis and
Computations 9 (2021) 892–939.'
date_created: 2021-04-04T22:01:21Z
date_published: 2021-03-21T00:00:00Z
date_updated: 2025-03-31T16:00:58Z
day: '21'
ddc:
- '510'
department:
- _id: JuFi
doi: 10.1007/s40072-021-00188-9
ec_funded: 1
external_id:
isi:
- '000631001700001'
file:
- access_level: open_access
checksum: 6529b609c9209861720ffa4685111bc6
content_type: application/pdf
creator: dernst
date_created: 2021-04-06T09:31:28Z
date_updated: 2021-04-06T09:31:28Z
file_id: '9309'
file_name: 2021_StochPartDiffEquation_Hensel.pdf
file_size: 727005
relation: main_file
success: 1
file_date_updated: 2021-04-06T09:31:28Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 892–939
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: 'Stochastics and Partial Differential Equations: Analysis and Computations'
publication_identifier:
eissn:
- 2194-041X
issn:
- 2194-0401
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Finite time extinction for the 1D stochastic porous medium equation with transport
noise
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 9
year: '2021'
...
---
_id: '9315'
abstract:
- lang: eng
text: We consider inertial iteration methods for Fermat–Weber location problem and
primal–dual three-operator splitting in real Hilbert spaces. To do these, we first
obtain weak convergence analysis and nonasymptotic O(1/n) convergence rate of
the inertial Krasnoselskii–Mann iteration for fixed point of nonexpansive operators
in infinite dimensional real Hilbert spaces under some seemingly easy to implement
conditions on the iterative parameters. One of our contributions is that the convergence
analysis and rate of convergence results are obtained using conditions which appear
not complicated and restrictive as assumed in other previous related results in
the literature. We then show that Fermat–Weber location problem and primal–dual
three-operator splitting are special cases of fixed point problem of nonexpansive
mapping and consequently obtain the convergence analysis of inertial iteration
methods for Fermat–Weber location problem and primal–dual three-operator splitting
in real Hilbert spaces. Some numerical implementations are drawn from primal–dual
three-operator splitting to support the theoretical analysis.
acknowledgement: The research of this author is supported by the Postdoctoral Fellowship
from Institute of Science and Technology (IST), Austria.
article_number: '75'
article_processing_charge: No
article_type: original
author:
- first_name: Olaniyi S.
full_name: Iyiola, Olaniyi S.
last_name: Iyiola
- first_name: Yekini
full_name: Shehu, Yekini
id: 3FC7CB58-F248-11E8-B48F-1D18A9856A87
last_name: Shehu
orcid: 0000-0001-9224-7139
citation:
ama: Iyiola OS, Shehu Y. New convergence results for inertial Krasnoselskii–Mann
iterations in Hilbert spaces with applications. Results in Mathematics.
2021;76(2). doi:10.1007/s00025-021-01381-x
apa: Iyiola, O. S., & Shehu, Y. (2021). New convergence results for inertial
Krasnoselskii–Mann iterations in Hilbert spaces with applications. Results
in Mathematics. Springer Nature. https://doi.org/10.1007/s00025-021-01381-x
chicago: Iyiola, Olaniyi S., and Yekini Shehu. “New Convergence Results for Inertial
Krasnoselskii–Mann Iterations in Hilbert Spaces with Applications.” Results
in Mathematics. Springer Nature, 2021. https://doi.org/10.1007/s00025-021-01381-x.
ieee: O. S. Iyiola and Y. Shehu, “New convergence results for inertial Krasnoselskii–Mann
iterations in Hilbert spaces with applications,” Results in Mathematics,
vol. 76, no. 2. Springer Nature, 2021.
ista: Iyiola OS, Shehu Y. 2021. New convergence results for inertial Krasnoselskii–Mann
iterations in Hilbert spaces with applications. Results in Mathematics. 76(2),
75.
mla: Iyiola, Olaniyi S., and Yekini Shehu. “New Convergence Results for Inertial
Krasnoselskii–Mann Iterations in Hilbert Spaces with Applications.” Results
in Mathematics, vol. 76, no. 2, 75, Springer Nature, 2021, doi:10.1007/s00025-021-01381-x.
short: O.S. Iyiola, Y. Shehu, Results in Mathematics 76 (2021).
corr_author: '1'
date_created: 2021-04-11T22:01:14Z
date_published: 2021-03-25T00:00:00Z
date_updated: 2024-10-09T21:00:33Z
day: '25'
department:
- _id: VlKo
doi: 10.1007/s00025-021-01381-x
external_id:
isi:
- '000632917700001'
intvolume: ' 76'
isi: 1
issue: '2'
language:
- iso: eng
month: '03'
oa_version: None
publication: Results in Mathematics
publication_identifier:
eissn:
- 1420-9012
issn:
- 1422-6383
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: New convergence results for inertial Krasnoselskii–Mann iterations in Hilbert
spaces with applications
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 76
year: '2021'
...
---
_id: '9316'
abstract:
- lang: eng
text: Embryo morphogenesis is impacted by dynamic changes in tissue material properties,
which have been proposed to occur via processes akin to phase transitions (PTs).
Here, we show that rigidity percolation provides a simple and robust theoretical
framework to predict material/structural PTs of embryonic tissues from local cell
connectivity. By using percolation theory, combined with directly monitoring dynamic
changes in tissue rheology and cell contact mechanics, we demonstrate that the
zebrafish blastoderm undergoes a genuine rigidity PT, brought about by a small
reduction in adhesion-dependent cell connectivity below a critical value. We quantitatively
predict and experimentally verify hallmarks of PTs, including power-law exponents
and associated discontinuities of macroscopic observables. Finally, we show that
this uniform PT depends on blastoderm cells undergoing meta-synchronous divisions
causing random and, consequently, uniform changes in cell connectivity. Collectively,
our theoretical and experimental findings reveal the structural basis of material
PTs in an organismal context.
acknowledged_ssus:
- _id: Bio
- _id: PreCl
acknowledgement: We thank Carl Goodrich and the members of the Heisenberg and Hannezo
groups, in particular Reka Korei, for help, technical advice, and discussions; and
the Bioimaging and zebrafish facilities of the IST Austria for continuous support.
This work was supported by the Elise Richter Program of Austrian Science Fund (FWF)
to N.I.P. ( V 736-B26 ) and the European Union (European Research Council Advanced
Grant 742573 to C.-P.H. and European Research Council Starting Grant 851288 to E.H.).
article_processing_charge: No
article_type: original
author:
- first_name: Nicoletta
full_name: Petridou, Nicoletta
id: 2A003F6C-F248-11E8-B48F-1D18A9856A87
last_name: Petridou
orcid: 0000-0002-8451-1195
- first_name: Bernat
full_name: Corominas-Murtra, Bernat
id: 43BE2298-F248-11E8-B48F-1D18A9856A87
last_name: Corominas-Murtra
orcid: 0000-0001-9806-5643
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
citation:
ama: Petridou N, Corominas-Murtra B, Heisenberg C-PJ, Hannezo EB. Rigidity percolation
uncovers a structural basis for embryonic tissue phase transitions. Cell.
2021;184(7):1914-1928.e19. doi:10.1016/j.cell.2021.02.017
apa: Petridou, N., Corominas-Murtra, B., Heisenberg, C.-P. J., & Hannezo, E.
B. (2021). Rigidity percolation uncovers a structural basis for embryonic tissue
phase transitions. Cell. Elsevier. https://doi.org/10.1016/j.cell.2021.02.017
chicago: Petridou, Nicoletta, Bernat Corominas-Murtra, Carl-Philipp J Heisenberg,
and Edouard B Hannezo. “Rigidity Percolation Uncovers a Structural Basis for Embryonic
Tissue Phase Transitions.” Cell. Elsevier, 2021. https://doi.org/10.1016/j.cell.2021.02.017.
ieee: N. Petridou, B. Corominas-Murtra, C.-P. J. Heisenberg, and E. B. Hannezo,
“Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions,”
Cell, vol. 184, no. 7. Elsevier, p. 1914–1928.e19, 2021.
ista: Petridou N, Corominas-Murtra B, Heisenberg C-PJ, Hannezo EB. 2021. Rigidity
percolation uncovers a structural basis for embryonic tissue phase transitions.
Cell. 184(7), 1914–1928.e19.
mla: Petridou, Nicoletta, et al. “Rigidity Percolation Uncovers a Structural Basis
for Embryonic Tissue Phase Transitions.” Cell, vol. 184, no. 7, Elsevier,
2021, p. 1914–1928.e19, doi:10.1016/j.cell.2021.02.017.
short: N. Petridou, B. Corominas-Murtra, C.-P.J. Heisenberg, E.B. Hannezo, Cell
184 (2021) 1914–1928.e19.
corr_author: '1'
date_created: 2021-04-11T22:01:14Z
date_published: 2021-04-01T00:00:00Z
date_updated: 2025-07-10T12:01:42Z
day: '01'
ddc:
- '570'
department:
- _id: CaHe
- _id: EdHa
doi: 10.1016/j.cell.2021.02.017
ec_funded: 1
external_id:
isi:
- '000636734000022'
pmid:
- '33730596'
file:
- access_level: open_access
checksum: 1e5295fbd9c2a459173ec45a0e8a7c2e
content_type: application/pdf
creator: cziletti
date_created: 2021-06-08T10:04:10Z
date_updated: 2021-06-08T10:04:10Z
file_id: '9534'
file_name: 2021_Cell_Petridou.pdf
file_size: 11405875
relation: main_file
success: 1
file_date_updated: 2021-06-08T10:04:10Z
has_accepted_license: '1'
intvolume: ' 184'
isi: 1
issue: '7'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 1914-1928.e19
pmid: 1
project:
- _id: 260F1432-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742573'
name: Interaction and feedback between cell mechanics and fate specification in
vertebrate gastrulation
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '851288'
name: Design Principles of Branching Morphogenesis
- _id: 2693FD8C-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: V00736
name: Tissue material properties in embryonic development
publication: Cell
publication_identifier:
eissn:
- 1097-4172
issn:
- 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/embryonic-tissue-undergoes-phase-transition/
scopus_import: '1'
status: public
title: Rigidity percolation uncovers a structural basis for embryonic tissue phase
transitions
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 184
year: '2021'
...
---
_id: '9317'
abstract:
- lang: eng
text: Given a locally finite X⊆Rd and a radius r≥0, the k-fold cover of X and r
consists of all points in Rd that have k or more points of X within distance r.
We consider two filtrations—one in scale obtained by fixing k and increasing r,
and the other in depth obtained by fixing r and decreasing k—and we compute the
persistence diagrams of both. While standard methods suffice for the filtration
in scale, we need novel geometric and topological concepts for the filtration
in depth. In particular, we introduce a rhomboid tiling in Rd+1 whose horizontal
integer slices are the order-k Delaunay mosaics of X, and construct a zigzag module
of Delaunay mosaics that is isomorphic to the persistence module of the multi-covers.
acknowledgement: "This project has received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme
(Grant Agreement No. 78818 Alpha), and by the DFG Collaborative Research Center
TRR 109, ‘Discretization in Geometry and Dynamics’, through Grant No. I02979-N35
of the Austrian Science Fund (FWF)\r\nOpen Access funding provided by the Institute
of Science and Technology (IST Austria)."
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Georg F
full_name: Osang, Georg F
id: 464B40D6-F248-11E8-B48F-1D18A9856A87
last_name: Osang
orcid: 0000-0002-8882-5116
citation:
ama: Edelsbrunner H, Osang GF. The multi-cover persistence of Euclidean balls. Discrete
and Computational Geometry. 2021;65:1296–1313. doi:10.1007/s00454-021-00281-9
apa: Edelsbrunner, H., & Osang, G. F. (2021). The multi-cover persistence of
Euclidean balls. Discrete and Computational Geometry. Springer Nature.
https://doi.org/10.1007/s00454-021-00281-9
chicago: Edelsbrunner, Herbert, and Georg F Osang. “The Multi-Cover Persistence
of Euclidean Balls.” Discrete and Computational Geometry. Springer Nature,
2021. https://doi.org/10.1007/s00454-021-00281-9.
ieee: H. Edelsbrunner and G. F. Osang, “The multi-cover persistence of Euclidean
balls,” Discrete and Computational Geometry, vol. 65. Springer Nature,
pp. 1296–1313, 2021.
ista: Edelsbrunner H, Osang GF. 2021. The multi-cover persistence of Euclidean balls.
Discrete and Computational Geometry. 65, 1296–1313.
mla: Edelsbrunner, Herbert, and Georg F. Osang. “The Multi-Cover Persistence of
Euclidean Balls.” Discrete and Computational Geometry, vol. 65, Springer
Nature, 2021, pp. 1296–1313, doi:10.1007/s00454-021-00281-9.
short: H. Edelsbrunner, G.F. Osang, Discrete and Computational Geometry 65 (2021)
1296–1313.
corr_author: '1'
date_created: 2021-04-11T22:01:15Z
date_published: 2021-03-31T00:00:00Z
date_updated: 2025-06-12T06:36:54Z
day: '31'
ddc:
- '516'
department:
- _id: HeEd
doi: 10.1007/s00454-021-00281-9
ec_funded: 1
external_id:
isi:
- '000635460400001'
pmid:
- '34720303'
file:
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content_type: application/pdf
creator: cchlebak
date_created: 2021-12-01T10:56:53Z
date_updated: 2021-12-01T10:56:53Z
file_id: '10394'
file_name: 2021_DisCompGeo_Edelsbrunner_Osang.pdf
file_size: 677704
relation: main_file
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file_date_updated: 2021-12-01T10:56:53Z
has_accepted_license: '1'
intvolume: ' 65'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 1296–1313
pmid: 1
project:
- _id: 266A2E9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '788183'
name: Alpha Shape Theory Extended
- _id: 2561EBF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I02979-N35
name: Persistence and stability of geometric complexes
publication: Discrete and Computational Geometry
publication_identifier:
eissn:
- 1432-0444
issn:
- 0179-5376
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '187'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: The multi-cover persistence of Euclidean balls
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 65
year: '2021'
...
---
_id: '9323'
abstract:
- lang: eng
text: This .zip File contains the data for figures presented in the main text and
supplementary material of "A singlet triplet hole spin qubit in planar Ge" by
D. Jirovec, et. al. The measurements were done using Labber Software and the data
is stored in the hdf5 file format. The files can be opened using either the Labber
Log Browser (https://labber.org/overview/) or Labber Python API (http://labber.org/online-doc/api/LogFile.html).
A single file is acquired with QCodes and features the corresponding data type.
XRD data are in .dat format and a code to open the data is provided. The code
for simulations is as well provided in Python.
article_processing_charge: No
author:
- first_name: Daniel
full_name: Jirovec, Daniel
id: 4C473F58-F248-11E8-B48F-1D18A9856A87
last_name: Jirovec
orcid: 0000-0002-7197-4801
citation:
ama: Jirovec D. Research data for “A singlet-triplet hole spin qubit planar Ge.”
2021. doi:10.15479/AT:ISTA:9323
apa: Jirovec, D. (2021). Research data for “A singlet-triplet hole spin qubit planar
Ge.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:9323
chicago: Jirovec, Daniel. “Research Data for ‘A Singlet-Triplet Hole Spin Qubit
Planar Ge.’” Institute of Science and Technology Austria, 2021. https://doi.org/10.15479/AT:ISTA:9323.
ieee: D. Jirovec, “Research data for ‘A singlet-triplet hole spin qubit planar Ge.’”
Institute of Science and Technology Austria, 2021.
ista: Jirovec D. 2021. Research data for ‘A singlet-triplet hole spin qubit planar
Ge’, Institute of Science and Technology Austria, 10.15479/AT:ISTA:9323.
mla: Jirovec, Daniel. Research Data for “A Singlet-Triplet Hole Spin Qubit Planar
Ge.” Institute of Science and Technology Austria, 2021, doi:10.15479/AT:ISTA:9323.
short: D. Jirovec, (2021).
contributor:
- contributor_type: project_member
first_name: Daniel
id: 4C473F58-F248-11E8-B48F-1D18A9856A87
last_name: Jirovec
date_created: 2021-04-14T09:50:22Z
date_published: 2021-04-14T00:00:00Z
date_updated: 2025-06-12T06:57:18Z
day: '14'
ddc:
- '530'
department:
- _id: GradSch
- _id: GeKa
doi: 10.15479/AT:ISTA:9323
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date_updated: 2021-04-14T09:48:47Z
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relation: main_file
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content_type: application/octet-stream
creator: djirovec
date_created: 2021-04-14T09:49:30Z
date_updated: 2021-04-14T09:49:30Z
file_id: '9325'
file_name: ReadMe
file_size: 4323
relation: main_file
success: 1
file_date_updated: 2021-04-14T09:49:30Z
has_accepted_license: '1'
month: '04'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
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relation: used_in_publication
status: public
status: public
title: Research data for "A singlet-triplet hole spin qubit planar Ge"
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '9329'
abstract:
- lang: eng
text: "Background: To understand information coding in single neurons, it is necessary
to analyze subthreshold synaptic events, action potentials (APs), and their interrelation
in different behavioral states. However, detecting excitatory postsynaptic potentials
(EPSPs) or currents (EPSCs) in behaving animals remains challenging, because of
unfavorable signal-to-noise ratio, high frequency, fluctuating amplitude, and
variable time course of synaptic events.\r\nNew method: We developed a method
for synaptic event detection, termed MOD (Machine-learning Optimal-filtering Detection-procedure),
which combines concepts of supervised machine learning and optimal Wiener filtering.
Experts were asked to manually score short epochs of data. The algorithm was trained
to obtain the optimal filter coefficients of a Wiener filter and the optimal detection
threshold. Scored and unscored data were then processed with the optimal filter,
and events were detected as peaks above threshold.\r\nResults: We challenged MOD
with EPSP traces in vivo in mice during spatial navigation and EPSC traces in
vitro in slices under conditions of enhanced transmitter release. The area under
the curve (AUC) of the receiver operating characteristics (ROC) curve was, on
average, 0.894 for in vivo and 0.969 for in vitro data sets, indicating high detection
accuracy and efficiency.\r\nComparison with existing methods: When benchmarked
using a (1 − AUC)−1 metric, MOD outperformed previous methods (template-fit, deconvolution,
and Bayesian methods) by an average factor of 3.13 for in vivo data sets, but
showed comparable (template-fit, deconvolution) or higher (Bayesian) computational
efficacy.\r\nConclusions: MOD may become an important new tool for large-scale,
real-time analysis of synaptic activity."
acknowledged_ssus:
- _id: SSU
acknowledgement: This project has received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme
(grant agreement number 692692 to P.J.) and the Fond zur Förderung der Wissenschaftlichen
Forschung (Z 312-B27, Wittgenstein award to P.J.). We thank Drs. Jozsef Csicsvari,
Christoph Lampert, and Federico Stella for critically reading previous manuscript
versions. We are also grateful to Drs. Josh Merel and Ben Shababo for their help
with applying the Bayesian detection method to our data. We also thank Florian Marr
for technical assistance, Eleftheria Kralli-Beller for manuscript editing, and the
Scientific Service Units of IST Austria for efficient support.
article_number: '109125'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Xiaomin
full_name: Zhang, Xiaomin
id: 423EC9C2-F248-11E8-B48F-1D18A9856A87
last_name: Zhang
- first_name: Alois
full_name: Schlögl, Alois
id: 45BF87EE-F248-11E8-B48F-1D18A9856A87
last_name: Schlögl
orcid: 0000-0002-5621-8100
- first_name: David H
full_name: Vandael, David H
id: 3AE48E0A-F248-11E8-B48F-1D18A9856A87
last_name: Vandael
orcid: 0000-0001-7577-1676
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: 'Zhang X, Schlögl A, Vandael DH, Jonas PM. MOD: A novel machine-learning optimal-filtering
method for accurate and efficient detection of subthreshold synaptic events in
vivo. Journal of Neuroscience Methods. 2021;357(6). doi:10.1016/j.jneumeth.2021.109125'
apa: 'Zhang, X., Schlögl, A., Vandael, D. H., & Jonas, P. M. (2021). MOD: A
novel machine-learning optimal-filtering method for accurate and efficient detection
of subthreshold synaptic events in vivo. Journal of Neuroscience Methods.
Elsevier. https://doi.org/10.1016/j.jneumeth.2021.109125'
chicago: 'Zhang, Xiaomin, Alois Schlögl, David H Vandael, and Peter M Jonas. “MOD:
A Novel Machine-Learning Optimal-Filtering Method for Accurate and Efficient Detection
of Subthreshold Synaptic Events in Vivo.” Journal of Neuroscience Methods.
Elsevier, 2021. https://doi.org/10.1016/j.jneumeth.2021.109125.'
ieee: 'X. Zhang, A. Schlögl, D. H. Vandael, and P. M. Jonas, “MOD: A novel machine-learning
optimal-filtering method for accurate and efficient detection of subthreshold
synaptic events in vivo,” Journal of Neuroscience Methods, vol. 357, no.
6. Elsevier, 2021.'
ista: 'Zhang X, Schlögl A, Vandael DH, Jonas PM. 2021. MOD: A novel machine-learning
optimal-filtering method for accurate and efficient detection of subthreshold
synaptic events in vivo. Journal of Neuroscience Methods. 357(6), 109125.'
mla: 'Zhang, Xiaomin, et al. “MOD: A Novel Machine-Learning Optimal-Filtering Method
for Accurate and Efficient Detection of Subthreshold Synaptic Events in Vivo.”
Journal of Neuroscience Methods, vol. 357, no. 6, 109125, Elsevier, 2021,
doi:10.1016/j.jneumeth.2021.109125.'
short: X. Zhang, A. Schlögl, D.H. Vandael, P.M. Jonas, Journal of Neuroscience Methods
357 (2021).
date_created: 2021-04-18T22:01:39Z
date_published: 2021-03-09T00:00:00Z
date_updated: 2025-06-12T06:39:15Z
day: '09'
ddc:
- '570'
department:
- _id: PeJo
- _id: ScienComp
doi: 10.1016/j.jneumeth.2021.109125
ec_funded: 1
external_id:
isi:
- '000661088500005'
pmid:
- '33711356'
file:
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checksum: 2a5800d91b96d08b525e17319dcd5e44
content_type: application/pdf
creator: dernst
date_created: 2021-04-19T08:30:22Z
date_updated: 2021-04-19T08:30:22Z
file_id: '9339'
file_name: 2021_JourNeuroscienceMeth_Zhang.pdf
file_size: 6924738
relation: main_file
success: 1
file_date_updated: 2021-04-19T08:30:22Z
has_accepted_license: '1'
intvolume: ' 357'
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issue: '6'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '692692'
name: Biophysics and circuit function of a giant cortical glutamatergic synapse
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00312
name: Synaptic communication in neuronal microcircuits
publication: Journal of Neuroscience Methods
publication_identifier:
eissn:
- 1872-678X
issn:
- 0165-0270
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'MOD: A novel machine-learning optimal-filtering method for accurate and efficient
detection of subthreshold synaptic events in vivo'
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 357
year: '2021'
...
---
_id: '9330'
abstract:
- lang: eng
text: In nerve cells the genes encoding for α2δ subunits of voltage-gated calcium
channels have been linked to synaptic functions and neurological disease. Here
we show that α2δ subunits are essential for the formation and organization of
glutamatergic synapses. Using a cellular α2δ subunit triple-knockout/knockdown
model, we demonstrate a failure in presynaptic differentiation evidenced by defective
presynaptic calcium channel clustering and calcium influx, smaller presynaptic
active zones, and a strongly reduced accumulation of presynaptic vesicle-associated
proteins (synapsin and vGLUT). The presynaptic defect is associated with the downscaling
of postsynaptic AMPA receptors and the postsynaptic density. The role of α2δ isoforms
as synaptic organizers is highly redundant, as each individual α2δ isoform can
rescue presynaptic calcium channel trafficking and expression of synaptic proteins.
Moreover, α2δ-2 and α2δ-3 with mutated metal ion-dependent adhesion sites can
fully rescue presynaptic synapsin expression but only partially calcium channel
trafficking, suggesting that the regulatory role of α2δ subunits is independent
from its role as a calcium channel subunit. Our findings influence the current
view on excitatory synapse formation. First, our study suggests that postsynaptic
differentiation is secondary to presynaptic differentiation. Second, the dependence
of presynaptic differentiation on α2δ implicates α2δ subunits as potential nucleation
points for the organization of synapses. Finally, our results suggest that α2δ
subunits act as transsynaptic organizers of glutamatergic synapses, thereby aligning
the synaptic active zone with the postsynaptic density.
acknowledged_ssus:
- _id: EM-Fac
acknowledgement: "We thank Arnold Schwartz for providing α2δ-1 knockout mice; Ariane
Benedetti, Sabine Baumgartner, Sandra Demetz, and Irene Mahlknecht for technical
support; Nadine Ortner and Andreas Lieb for electrophysiological experiments; the
team of the Electron Microscopy Facility at the Institute of Science and Technology
Austria for technical support related to ultrastructural analysis; Hermann Dietrich
and Anja Beierfuß and her team for animal care; Jutta Engel and Jörg Striessnig
for critical discussions; and Bruno Benedetti and Bernhard Flucher for critical
discussions and reading the manuscript. This study was supported by Austrian Science
Fund Grants P24079, F44060, F44150, and DOC30-B30 (to G.J.O.) and T855 (to M.C.),
European Research Council Grant AdG 694539 (to R.S.), Deutsche Forschungsgemeinschaft\r\nGrant
SFB1348-TP A03 (to M.M.), and Interdisziplinäre Zentrum für Klinische Forschung
Münster Grant Mi3/004/19 (to M.M.). This work is part of the PhD theses of C.L.S.,
S.M.G., and C.A."
article_processing_charge: No
article_type: original
author:
- first_name: Clemens L.
full_name: Schöpf, Clemens L.
last_name: Schöpf
- first_name: Cornelia
full_name: Ablinger, Cornelia
last_name: Ablinger
- first_name: Stefanie M.
full_name: Geisler, Stefanie M.
last_name: Geisler
- first_name: Ruslan I.
full_name: Stanika, Ruslan I.
last_name: Stanika
- first_name: Marta
full_name: Campiglio, Marta
last_name: Campiglio
- first_name: Walter
full_name: Kaufmann, Walter
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: Benedikt
full_name: Nimmervoll, Benedikt
last_name: Nimmervoll
- first_name: Bettina
full_name: Schlick, Bettina
last_name: Schlick
- first_name: Johannes
full_name: Brockhaus, Johannes
last_name: Brockhaus
- first_name: Markus
full_name: Missler, Markus
last_name: Missler
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Gerald J.
full_name: Obermair, Gerald J.
last_name: Obermair
citation:
ama: Schöpf CL, Ablinger C, Geisler SM, et al. Presynaptic α2δ subunits are key
organizers of glutamatergic synapses. Proceedings of the National Academy of
Sciences of the United States of America. 2021;118(14). doi:10.1073/pnas.1920827118
apa: Schöpf, C. L., Ablinger, C., Geisler, S. M., Stanika, R. I., Campiglio, M.,
Kaufmann, W., … Obermair, G. J. (2021). Presynaptic α2δ subunits are key organizers
of glutamatergic synapses. Proceedings of the National Academy of Sciences
of the United States of America. National Academy of Sciences. https://doi.org/10.1073/pnas.1920827118
chicago: Schöpf, Clemens L., Cornelia Ablinger, Stefanie M. Geisler, Ruslan I. Stanika,
Marta Campiglio, Walter Kaufmann, Benedikt Nimmervoll, et al. “Presynaptic Α2δ
Subunits Are Key Organizers of Glutamatergic Synapses.” Proceedings of the
National Academy of Sciences of the United States of America. National Academy
of Sciences, 2021. https://doi.org/10.1073/pnas.1920827118.
ieee: C. L. Schöpf et al., “Presynaptic α2δ subunits are key organizers of
glutamatergic synapses,” Proceedings of the National Academy of Sciences of
the United States of America, vol. 118, no. 14. National Academy of Sciences,
2021.
ista: Schöpf CL, Ablinger C, Geisler SM, Stanika RI, Campiglio M, Kaufmann W, Nimmervoll
B, Schlick B, Brockhaus J, Missler M, Shigemoto R, Obermair GJ. 2021. Presynaptic
α2δ subunits are key organizers of glutamatergic synapses. Proceedings of the
National Academy of Sciences of the United States of America. 118(14).
mla: Schöpf, Clemens L., et al. “Presynaptic Α2δ Subunits Are Key Organizers of
Glutamatergic Synapses.” Proceedings of the National Academy of Sciences of
the United States of America, vol. 118, no. 14, National Academy of Sciences,
2021, doi:10.1073/pnas.1920827118.
short: C.L. Schöpf, C. Ablinger, S.M. Geisler, R.I. Stanika, M. Campiglio, W. Kaufmann,
B. Nimmervoll, B. Schlick, J. Brockhaus, M. Missler, R. Shigemoto, G.J. Obermair,
Proceedings of the National Academy of Sciences of the United States of America
118 (2021).
date_created: 2021-04-18T22:01:40Z
date_published: 2021-04-06T00:00:00Z
date_updated: 2025-06-12T06:56:21Z
day: '06'
ddc:
- '570'
department:
- _id: EM-Fac
- _id: RySh
doi: 10.1073/pnas.1920827118
ec_funded: 1
external_id:
isi:
- '000637398300002'
pmid:
- '33782113'
file:
- access_level: open_access
checksum: dd014f68ae9d7d8d8fc4139a24e04506
content_type: application/pdf
creator: dernst
date_created: 2021-04-19T10:10:56Z
date_updated: 2021-04-19T10:10:56Z
file_id: '9340'
file_name: 2021_PNAS_Schoepf.pdf
file_size: 2603911
relation: main_file
success: 1
file_date_updated: 2021-04-19T10:10:56Z
has_accepted_license: '1'
intvolume: ' 118'
isi: 1
issue: '14'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 25CA28EA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694539'
name: 'In situ analysis of single channel subunit composition in neurons: physiological
implication in synaptic plasticity and behaviour'
publication: Proceedings of the National Academy of Sciences of the United States
of America
publication_identifier:
eissn:
- 1091-6490
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Presynaptic α2δ subunits are key organizers of glutamatergic synapses
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 118
year: '2021'
...