[{"acknowledgement":"We are grateful to M. Sixt, T. Bollenbach, and E. Martin-Blanco for advice and the service facilities of the IST Austria and MPI-CBG for continuous help. M.B., G.S., S.W.G., and C.-P.H. synergistically and equally developed the presented ideas and the experimental and theoretical approaches. M.B. and P.C. performed the experiments; G.S. developed the theory; and R.H., F.O., and J.R. contributed to the experimental work. This work was supported by a grant from the Fonds zur Förderung der wissenschaftlichen Forschung (FWF) and the Deutsche Forschungsgemeinschaft (DFG) (I930-B20) to C.-P.H., S.W.G., and G.S.","scopus_import":"1","issue":"6104","publication":"Science","publist_id":"3778","language":[{"iso":"eng"}],"OA_type":"closed access","abstract":[{"text":"Contractile actomyosin rings drive various fundamental morphogenetic processes ranging from cytokinesis to wound healing. Actomyosin rings are generally thought to function by circumferential contraction. Here, we show that the spreading of the enveloping cell layer (EVL) over the yolk cell during zebrafish gastrulation is driven by a contractile actomyosin ring. In contrast to previous suggestions, we find that this ring functions not only by circumferential contraction but also by a flow-friction mechanism. This generates a pulling force through resistance against retrograde actomyosin flow. EVL spreading proceeds normally in situations where circumferential contraction is unproductive, indicating that the flow-friction mechanism is sufficient. Thus, actomyosin rings can function in epithelial morphogenesis through a combination of cable-constriction and flow-friction mechanisms.","lang":"eng"}],"oa_version":"None","type":"journal_article","article_type":"original","status":"public","date_created":"2018-12-11T12:00:30Z","author":[{"first_name":"Martin","last_name":"Behrndt","id":"3ECECA3A-F248-11E8-B48F-1D18A9856A87","full_name":"Behrndt, Martin"},{"full_name":"Salbreux, Guillaume","last_name":"Salbreux","first_name":"Guillaume"},{"full_name":"Campinho, Pedro","orcid":"0000-0002-8526-5416","id":"3AFBBC42-F248-11E8-B48F-1D18A9856A87","first_name":"Pedro","last_name":"Campinho"},{"full_name":"Hauschild, Robert","orcid":"0000-0001-9843-3522","first_name":"Robert","last_name":"Hauschild","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Felix","last_name":"Oswald","full_name":"Oswald, Felix"},{"id":"4220E59C-F248-11E8-B48F-1D18A9856A87","last_name":"Roensch","first_name":"Julia","full_name":"Roensch, Julia"},{"full_name":"Grill, Stephan","last_name":"Grill","first_name":"Stephan"},{"full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","first_name":"Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87"}],"title":"Forces driving epithelial spreading in zebrafish gastrulation","_id":"2950","date_updated":"2026-07-29T10:07:18Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","page":"257 - 260","citation":{"mla":"Behrndt, Martin, et al. “Forces Driving Epithelial Spreading in Zebrafish Gastrulation.” <i>Science</i>, vol. 338, no. 6104, American Association for the Advancement of Science, 2012, pp. 257–60, doi:<a href=\"https://doi.org/10.1126/science.1224143\">10.1126/science.1224143</a>.","ama":"Behrndt M, Salbreux G, Campinho P, et al. Forces driving epithelial spreading in zebrafish gastrulation. <i>Science</i>. 2012;338(6104):257-260. doi:<a href=\"https://doi.org/10.1126/science.1224143\">10.1126/science.1224143</a>","ista":"Behrndt M, Salbreux G, Campinho P, Hauschild R, Oswald F, Roensch J, Grill S, Heisenberg C-PJ. 2012. Forces driving epithelial spreading in zebrafish gastrulation. Science. 338(6104), 257–260.","ieee":"M. Behrndt <i>et al.</i>, “Forces driving epithelial spreading in zebrafish gastrulation,” <i>Science</i>, vol. 338, no. 6104. American Association for the Advancement of Science, pp. 257–260, 2012.","short":"M. Behrndt, G. Salbreux, P. Campinho, R. Hauschild, F. Oswald, J. Roensch, S. Grill, C.-P.J. Heisenberg, Science 338 (2012) 257–260.","chicago":"Behrndt, Martin, Guillaume Salbreux, Pedro Campinho, Robert Hauschild, Felix Oswald, Julia Roensch, Stephan Grill, and Carl-Philipp J Heisenberg. “Forces Driving Epithelial Spreading in Zebrafish Gastrulation.” <i>Science</i>. American Association for the Advancement of Science, 2012. <a href=\"https://doi.org/10.1126/science.1224143\">https://doi.org/10.1126/science.1224143</a>.","apa":"Behrndt, M., Salbreux, G., Campinho, P., Hauschild, R., Oswald, F., Roensch, J., … Heisenberg, C.-P. J. (2012). Forces driving epithelial spreading in zebrafish gastrulation. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1224143\">https://doi.org/10.1126/science.1224143</a>"},"project":[{"call_identifier":"FWF","name":"Control of Epithelial Cell Layer Spreading in Zebrafish","_id":"252ABD0A-B435-11E9-9278-68D0E5697425","grant_number":"I930-B20"}],"related_material":{"record":[{"relation":"dissertation_contains","id":"1403","status":"public"}]},"publisher":"American Association for the Advancement of Science","department":[{"_id":"CaHe"},{"_id":"Bio"}],"month":"10","external_id":{"pmid":["23066079"],"isi":["000309712300046"]},"corr_author":"1","day":"12","doi":"10.1126/science.1224143","volume":338,"isi":1,"intvolume":"       338","publication_status":"published","year":"2012","quality_controlled":"1","pmid":1,"acknowledged_ssus":[{"_id":"SSU"}],"fulldoi":"https://doi.org/10.1126/science.1224143","article_processing_charge":"No","date_published":"2012-10-12T00:00:00Z"},{"page":"200 - 212","citation":{"ista":"Danowski P. 2012. Kontext Open Access: Creative Commons. Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare. 65(2), 200–212.","short":"P. Danowski, Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare 65 (2012) 200–212.","ieee":"P. Danowski, “Kontext Open Access: Creative Commons,” <i>Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare</i>, vol. 65, no. 2. Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare, pp. 200–212, 2012.","ama":"Danowski P. Kontext Open Access: Creative Commons. <i>Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare</i>. 2012;65(2):200-212.","mla":"Danowski, Patrick. “Kontext Open Access: Creative Commons.” <i>Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare</i>, vol. 65, no. 2, Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare, 2012, pp. 200–12.","apa":"Danowski, P. (2012). Kontext Open Access: Creative Commons. <i>Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare</i>. Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare.","chicago":"Danowski, Patrick. “Kontext Open Access: Creative Commons.” <i>Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare</i>. Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare, 2012."},"license":"https://creativecommons.org/licenses/by/4.0/","date_updated":"2026-08-12T14:15:14Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"last_name":"Danowski","first_name":"Patrick","id":"2EBD1598-F248-11E8-B48F-1D18A9856A87","full_name":"Danowski, Patrick","orcid":"0000-0002-6026-4409"}],"date_created":"2018-12-11T12:00:35Z","status":"public","title":"Kontext Open Access: Creative Commons","_id":"2965","abstract":[{"text":"Dieser Artikel soll die sechs verschiedenen Creative Commons Lizenzen erläutern und ihre Bedeutung im Rahmen des wissenschaftlichen Publizierens und des Open Access erklären (CC-BY, CC-BY-SA, CC-BY-NC, CC-BY-ND, CC-BYNC-SA, CC-BY-NC-ND).","lang":"eng"}],"type":"journal_article","oa_version":"Published Version","language":[{"iso":"ger"}],"publist_id":"3754","scopus_import":"1","issue":"2","publication":"Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare","article_processing_charge":"No","has_accepted_license":"1","file_date_updated":"2020-07-14T12:45:57Z","date_published":"2012-09-01T00:00:00Z","main_file_link":[{"open_access":"1","url":" http://hdl.handle.net/10760/17625"}],"das_tickbox":"1","ddc":["020"],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"intvolume":"        65","publication_status":"published","year":"2012","popular_science":"1","file":[{"access_level":"open_access","creator":"system","relation":"main_file","checksum":"162eea47d9d840c26b496ba6ae4d1c09","date_created":"2018-12-12T10:08:42Z","file_name":"IST-2012-95-v1+1_sp-beitrag_danowski_kontext_open_access_creative_commons.pdf","content_type":"application/pdf","date_updated":"2020-07-14T12:45:57Z","file_size":503345,"file_id":"4703"}],"volume":65,"oa":1,"corr_author":"1","pubrep_id":"95","day":"01","publisher":"Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare","department":[{"_id":"E-Lib"}],"month":"09"},{"external_id":{"isi":["000208906100033"]},"month":"01","department":[{"_id":"ScienComp"},{"_id":"PeJo"}],"publisher":"Hindawi Publishing Corporation","day":"01","pubrep_id":"947","corr_author":"1","oa":1,"volume":2011,"file":[{"file_name":"IST-2018-947-v1+1_2011_Schloegl_BioSig.pdf","date_updated":"2020-07-14T12:46:35Z","content_type":"application/pdf","file_size":2863551,"file_id":"4642","access_level":"open_access","relation":"main_file","creator":"system","date_created":"2018-12-12T10:07:44Z","checksum":"8263bbf255171f2054f43f3db5f53b6e"}],"doi":"10.1155/2011/935364","article_number":"935364","isi":1,"quality_controlled":"1","year":"2011","publication_status":"published","intvolume":"      2011","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"ddc":["005"],"fulldoi":"https://doi.org/10.1155/2011/935364","date_published":"2011-01-01T00:00:00Z","file_date_updated":"2020-07-14T12:46:35Z","has_accepted_license":"1","article_processing_charge":"No","publication":"Computational Intelligence and Neuroscience","scopus_import":"1","language":[{"iso":"eng"}],"publist_id":"7330","oa_version":"Published Version","type":"journal_article","abstract":[{"lang":"eng","text":"BioSig is an open source software library for biomedical signal processing. The aim of the BioSig project is to foster research in biomedical signal processing by providing free and open source software tools for many different application areas. Some of the areas where BioSig can be employed are neuroinformatics, brain-computer interfaces, neurophysiology, psychology, cardiovascular systems, and sleep research. Moreover, the analysis of biosignals such as the electroencephalogram (EEG), electrocorticogram (ECoG), electrocardiogram (ECG), electrooculogram (EOG), electromyogram (EMG), or respiration signals is a very relevant element of the BioSig project. Specifically, BioSig provides solutions for data acquisition, artifact processing, quality control, feature extraction, classification, modeling, and data visualization, to name a few. In this paper, we highlight several methods to help students and researchers to work more efficiently with biomedical signals. 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BioSig: The free and open source software library for biomedical signal processing. <i>Computational Intelligence and Neuroscience</i>. 2011;2011. doi:<a href=\"https://doi.org/10.1155/2011/935364\">10.1155/2011/935364</a>","mla":"Schlögl, Alois, et al. “BioSig: The Free and Open Source Software Library for Biomedical Signal Processing.” <i>Computational Intelligence and Neuroscience</i>, vol. 2011, 935364, Hindawi Publishing Corporation, 2011, doi:<a href=\"https://doi.org/10.1155/2011/935364\">10.1155/2011/935364</a>.","ista":"Schlögl A, Vidaurre C, Sander T. 2011. BioSig: The free and open source software library for biomedical signal processing. Computational Intelligence and Neuroscience. 2011, 935364.","ieee":"A. Schlögl, C. Vidaurre, and T. Sander, “BioSig: The free and open source software library for biomedical signal processing,” <i>Computational Intelligence and Neuroscience</i>, vol. 2011. Hindawi Publishing Corporation, 2011.","short":"A. Schlögl, C. Vidaurre, T. Sander, Computational Intelligence and Neuroscience 2011 (2011).","chicago":"Schlögl, Alois, Carmen Vidaurre, and Tilmann Sander. “BioSig: The Free and Open Source Software Library for Biomedical Signal Processing.” <i>Computational Intelligence and Neuroscience</i>. Hindawi Publishing Corporation, 2011. <a href=\"https://doi.org/10.1155/2011/935364\">https://doi.org/10.1155/2011/935364</a>.","apa":"Schlögl, A., Vidaurre, C., &#38; Sander, T. (2011). BioSig: The free and open source software library for biomedical signal processing. <i>Computational Intelligence and Neuroscience</i>. Hindawi Publishing Corporation. <a href=\"https://doi.org/10.1155/2011/935364\">https://doi.org/10.1155/2011/935364</a>"}},{"oa":1,"day":"09","publication":"2011 IEEE International Symposium on Biomedical Imaging: from Nano to Micro","publisher":"Institute of Electrical and Electronics Engineers","department":[{"_id":"Bio"}],"publication_identifier":{"eissn":["1945-8452"],"issn":["1945-7928"],"isbn":["978-1-4244-4127-3"]},"month":"06","doi":"10.1109/isbi.2011.5872394","language":[{"iso":"eng"}],"status":"public","date_created":"2021-08-19T11:49:58Z","author":[{"orcid":"0000-0003-1216-9105","full_name":"Sommer, Christoph M","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","first_name":"Christoph M","last_name":"Sommer"},{"first_name":"Christoph","last_name":"Straehle","full_name":"Straehle, Christoph"},{"full_name":"Köthe, Ullrich","last_name":"Köthe","first_name":"Ullrich"},{"full_name":"Hamprecht, Fred A.","first_name":"Fred A.","last_name":"Hamprecht"}],"title":"Ilastik: Interactive learning and segmentation toolkit","_id":"9943","extern":"1","abstract":[{"text":"Segmentation is the process of partitioning digital images into meaningful regions. The analysis of biological high content images often requires segmentation as a first step. We propose ilastik as an easy-to-use tool which allows the user without expertise in image processing to perform segmentation and classification in a unified way. ilastik learns from labels provided by the user through a convenient mouse interface. Based on these labels, ilastik infers a problem specific segmentation. A random forest classifier is used in the learning step, in which each pixel's neighborhood is characterized by a set of generic (nonlinear) features. ilastik supports up to three spatial plus one spectral dimension and makes use of all dimensions in the feature calculation. ilastik provides realtime feedback that enables the user to interactively refine the segmentation result and hence further fine-tune the classifier. An uncertainty measure guides the user to ambiguous regions in the images. Real time performance is achieved by multi-threading which fully exploits the capabilities of modern multi-core machines. Once a classifier has been trained on a set of representative images, it can be exported and used to automatically process a very large number of images (e.g. using the CellProfiler pipeline). ilastik is an open source project and released under the BSD license at www.ilastik.org.","lang":"eng"}],"publication_status":"published","oa_version":"Preprint","type":"conference","year":"2011","quality_controlled":"1","article_processing_charge":"No","citation":{"apa":"Sommer, C. M., Straehle, C., Köthe, U., &#38; Hamprecht, F. A. (2011). Ilastik: Interactive learning and segmentation toolkit. In <i>2011 IEEE International Symposium on Biomedical Imaging: from Nano to Micro</i>. Chicago, Illinois, USA: Institute of Electrical and Electronics Engineers. <a href=\"https://doi.org/10.1109/isbi.2011.5872394\">https://doi.org/10.1109/isbi.2011.5872394</a>","chicago":"Sommer, Christoph M, Christoph Straehle, Ullrich Köthe, and Fred A. Hamprecht. “Ilastik: Interactive Learning and Segmentation Toolkit.” In <i>2011 IEEE International Symposium on Biomedical Imaging: From Nano to Micro</i>. Institute of Electrical and Electronics Engineers, 2011. <a href=\"https://doi.org/10.1109/isbi.2011.5872394\">https://doi.org/10.1109/isbi.2011.5872394</a>.","short":"C.M. Sommer, C. Straehle, U. Köthe, F.A. Hamprecht, in:, 2011 IEEE International Symposium on Biomedical Imaging: From Nano to Micro, Institute of Electrical and Electronics Engineers, 2011.","ieee":"C. M. Sommer, C. Straehle, U. Köthe, and F. A. 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Institute of Electrical and Electronics Engineers; 2011. doi:<a href=\"https://doi.org/10.1109/isbi.2011.5872394\">10.1109/isbi.2011.5872394</a>","mla":"Sommer, Christoph M., et al. “Ilastik: Interactive Learning and Segmentation Toolkit.” <i>2011 IEEE International Symposium on Biomedical Imaging: From Nano to Micro</i>, Institute of Electrical and Electronics Engineers, 2011, doi:<a href=\"https://doi.org/10.1109/isbi.2011.5872394\">10.1109/isbi.2011.5872394</a>."},"keyword":["image segmentation","biomedical imaging","three dimensional displays","neurons","retina","observers","image color analysis"],"conference":{"end_date":"2011-04-02","start_date":"2011-03-30","name":"ISBI: International Symposium on Biomedical Imaging","location":"Chicago, Illinois, USA"},"date_published":"2011-06-09T00:00:00Z","main_file_link":[{"open_access":"1","url":"https://www.researchgate.net/publication/224241106_Ilastik_Interactive_learning_and_segmentation_toolkit"}],"date_updated":"2023-02-23T14:13:38Z","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","fulldoi":"https://doi.org/10.1109/isbi.2011.5872394"},{"page":"331-355","citation":{"ista":"Schlögl A, Vidaurre C, Müller K-R. 2010.Adaptive Methods in BCI Research - An Introductory Tutorial. In: Brain-Computer Interfaces. The Frontiers Collection, , 331–355.","short":"A. Schlögl, C. Vidaurre, K.-R. Müller, in:, B. Graimann, G. Pfurtscheller, B. Allison (Eds.), Brain-Computer Interfaces, 1st ed., Springer, Berlin, Heidelberg, 2010, pp. 331–355.","ieee":"A. Schlögl, C. Vidaurre, and K.-R. Müller, “Adaptive Methods in BCI Research - An Introductory Tutorial,” in <i>Brain-Computer Interfaces</i>, 1st ed., B. Graimann, G. Pfurtscheller, and B. Allison, Eds. Berlin, Heidelberg: Springer, 2010, pp. 331–355.","mla":"Schlögl, Alois, et al. “Adaptive Methods in BCI Research - An Introductory Tutorial.” <i>Brain-Computer Interfaces</i>, edited by Bernhard Graimann et al., 1st ed., Springer, 2010, pp. 331–55, doi:<a href=\"https://doi.org/10.1007/978-3-642-02091-9_18\">10.1007/978-3-642-02091-9_18</a>.","ama":"Schlögl A, Vidaurre C, Müller K-R. Adaptive Methods in BCI Research - An Introductory Tutorial. In: Graimann B, Pfurtscheller G, Allison B, eds. <i>Brain-Computer Interfaces</i>. 1st ed. FRONTCOLL. Berlin, Heidelberg: Springer; 2010:331-355. doi:<a href=\"https://doi.org/10.1007/978-3-642-02091-9_18\">10.1007/978-3-642-02091-9_18</a>","apa":"Schlögl, A., Vidaurre, C., &#38; Müller, K.-R. (2010). Adaptive Methods in BCI Research - An Introductory Tutorial. In B. Graimann, G. Pfurtscheller, &#38; B. Allison (Eds.), <i>Brain-Computer Interfaces</i> (1st ed., pp. 331–355). Berlin, Heidelberg: Springer. <a href=\"https://doi.org/10.1007/978-3-642-02091-9_18\">https://doi.org/10.1007/978-3-642-02091-9_18</a>","chicago":"Schlögl, Alois, Carmen Vidaurre, and Klaus-Robert Müller. “Adaptive Methods in BCI Research - An Introductory Tutorial.” In <i>Brain-Computer Interfaces</i>, edited by Bernhard Graimann, Gert Pfurtscheller, and Brendan Allison, 1st ed., 331–55. FRONTCOLL. Berlin, Heidelberg: Springer, 2010. <a href=\"https://doi.org/10.1007/978-3-642-02091-9_18\">https://doi.org/10.1007/978-3-642-02091-9_18</a>."},"date_updated":"2024-10-21T06:03:06Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","date_created":"2024-02-14T09:56:00Z","author":[{"orcid":"0000-0002-5621-8100","full_name":"Schlögl, Alois","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","first_name":"Alois","last_name":"Schlögl"},{"last_name":"Vidaurre","first_name":"Carmen","full_name":"Vidaurre, Carmen"},{"first_name":"Klaus-Robert","last_name":"Müller","full_name":"Müller, Klaus-Robert"}],"title":"Adaptive Methods in BCI Research - An Introductory Tutorial","_id":"14983","abstract":[{"lang":"eng","text":"This chapter tackles a difficult challenge: presenting signal processing material to non-experts. This chapter is meant to be comprehensible to people who have some math background, including a course in linear algebra and basic statistics, but do not specialize in mathematics, engineering, or related fields. Some formulas assume the reader is familiar with matrices and basic matrix operations, but not more advanced material. Furthermore, we tried to make the chapter readable even if you skip the formulas. Nevertheless, we include some simple methods to demonstrate the basics of adaptive data processing, then we proceed with some advanced methods that are fundamental in adaptive signal processing, and are likely to be useful in a variety of applications. The advanced algorithms are also online available [30]. In the second part, these techniques are applied to some real-world BCI data."}],"oa_version":"None","type":"book_chapter","language":[{"iso":"eng"}],"scopus_import":"1","publication":"Brain-Computer Interfaces","publication_identifier":{"issn":["1612-3018"],"isbn":["9783642020902"],"eisbn":["9783642020919"]},"acknowledgement":"This work was supported by the EU grants “BrainCom” (FP6-2004-Mobility-5 Grant No 024259) and “Multi-adaptive BCI” (MEIF-CT-2006 Grant No 040666). Furthermore, we thank Matthias Krauledat for fruitful discussions and tools for generating Fig. 5.","article_processing_charge":"No","alternative_title":["The Frontiers Collection"],"date_published":"2010-09-06T00:00:00Z","fulldoi":"https://doi.org/10.1007/978-3-642-02091-9_18","editor":[{"first_name":"Bernhard","last_name":"Graimann","full_name":"Graimann, Bernhard"},{"full_name":"Pfurtscheller, Gert","first_name":"Gert","last_name":"Pfurtscheller"},{"first_name":"Brendan","last_name":"Allison","full_name":"Allison, Brendan"}],"place":"Berlin, Heidelberg","publication_status":"published","quality_controlled":"1","year":"2010","series_title":"FRONTCOLL","edition":"1","doi":"10.1007/978-3-642-02091-9_18","corr_author":"1","day":"06","publisher":"Springer","department":[{"_id":"ScienComp"}],"month":"09"},{"isi":1,"volume":29,"doi":"10.1038/emboj.2010.182","day":"18","oa":1,"external_id":{"pmid":["20717145"],"isi":["000281006400009"]},"publisher":"Wiley-Blackwell","month":"08","department":[{"_id":"Bio"},{"_id":"CaHe"}],"date_published":"2010-08-18T00:00:00Z","article_processing_charge":"No","fulldoi":"https://doi.org/10.1038/emboj.2010.182","acknowledged_ssus":[{"_id":"Bio"}],"main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924654/"}],"publication_status":"published","pmid":1,"quality_controlled":"1","year":"2010","intvolume":"        29","language":[{"iso":"eng"}],"publist_id":"1962","publication":"EMBO Journal","scopus_import":"1","issue":"16","page":"2753 - 2768","citation":{"mla":"Papusheva, Ekaterina, and Carl-Philipp J. Heisenberg. “Spatial Organization of Adhesion: Force-Dependent Regulation and Function in Tissue Morphogenesis.” <i>EMBO Journal</i>, vol. 29, no. 16, Wiley-Blackwell, 2010, pp. 2753–68, doi:<a href=\"https://doi.org/10.1038/emboj.2010.182\">10.1038/emboj.2010.182</a>.","ama":"Papusheva E, Heisenberg C-PJ. Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis. <i>EMBO Journal</i>. 2010;29(16):2753-2768. doi:<a href=\"https://doi.org/10.1038/emboj.2010.182\">10.1038/emboj.2010.182</a>","ieee":"E. Papusheva and C.-P. J. Heisenberg, “Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis,” <i>EMBO Journal</i>, vol. 29, no. 16. Wiley-Blackwell, pp. 2753–2768, 2010.","short":"E. Papusheva, C.-P.J. Heisenberg, EMBO Journal 29 (2010) 2753–2768.","ista":"Papusheva E, Heisenberg C-PJ. 2010. Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis. EMBO Journal. 29(16), 2753–2768.","chicago":"Papusheva, Ekaterina, and Carl-Philipp J Heisenberg. “Spatial Organization of Adhesion: Force-Dependent Regulation and Function in Tissue Morphogenesis.” <i>EMBO Journal</i>. Wiley-Blackwell, 2010. <a href=\"https://doi.org/10.1038/emboj.2010.182\">https://doi.org/10.1038/emboj.2010.182</a>.","apa":"Papusheva, E., &#38; Heisenberg, C.-P. J. (2010). Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis. <i>EMBO Journal</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1038/emboj.2010.182\">https://doi.org/10.1038/emboj.2010.182</a>"},"date_updated":"2025-09-30T09:29:30Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","title":"Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis","_id":"4157","date_created":"2018-12-11T12:07:17Z","author":[{"full_name":"Papusheva, Ekaterina","last_name":"Papusheva","first_name":"Ekaterina","id":"41DB591E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J","last_name":"Heisenberg"}],"status":"public","oa_version":"Submitted Version","type":"journal_article","abstract":[{"text":"Integrin- and cadherin-mediated adhesion is central for cell and tissue morphogenesis, allowing cells and tissues to change shape without loosing integrity. Studies predominantly in cell culture showed that mechanosensation through adhesion structures is achieved by force-mediated modulation of their molecular composition. The specific molecular composition of adhesion sites in turn determines their signalling activity and dynamic reorganization. Here, we will review how adhesion sites respond to mecanical stimuli, and how spatially and temporally regulated signalling from different adhesion sites controls cell migration and tissue morphogenesis.","lang":"eng"}]}]