---
OA_place: publisher
_id: '2964'
abstract:
- lang: eng
  text: 'CA3 pyramidal neurons are important for memory formation and pattern completion
    in the hippocampal network. These neurons receive multiple excitatory inputs from
    numerous sources. Therefore, the rules of spatiotemporal integration of multiple
    synaptic inputs and propagation of action potentials are important to understand
    how CA3 neurons contribute to higher brain functions at cellular level. By using
    confocally targeted patch-clamp recording techniques, we investigated the biophysical
    properties of rat CA3 pyramidal neuron dendrites. We found two distinct dendritic
    domains critical for action potential initiation and propagation: In the proximal
    domain, action potentials initiated in the axon backpropagate actively with large
    amplitude and fast time course. In the distal domain, Na+-channel mediated dendritic
    spikes are efficiently evoked by local dendritic depolarization or waveforms mimicking
    synaptic events. These findings can be explained by a high Na+-to-K+ conductance
    density ratio of CA3 pyramidal neuron dendrites. The results challenge the prevailing
    view that proximal mossy fiber inputs activate CA3 pyramidal neurons more efficiently
    than distal perforant inputs by showing that the distal synapses trigger a different
    form of activity represented by dendritic spikes. The high probability of dendritic
    spike initiation in the distal area may enhance the computational power of CA3
    pyramidal neurons in the hippocampal network.  '
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Sooyun
  full_name: Kim, Sooyun
  id: 394AB1C8-F248-11E8-B48F-1D18A9856A87
  last_name: Kim
citation:
  ama: Kim S. Active properties of hippocampal CA3 pyramidal neuron dendrites. 2012.
  apa: Kim, S. (2012). <i>Active properties of hippocampal CA3 pyramidal neuron dendrites</i>.
    Institute of Science and Technology Austria.
  chicago: Kim, Sooyun. “Active Properties of Hippocampal CA3 Pyramidal Neuron Dendrites.”
    Institute of Science and Technology Austria, 2012.
  ieee: S. Kim, “Active properties of hippocampal CA3 pyramidal neuron dendrites,”
    Institute of Science and Technology Austria, 2012.
  ista: Kim S. 2012. Active properties of hippocampal CA3 pyramidal neuron dendrites.
    Institute of Science and Technology Austria.
  mla: Kim, Sooyun. <i>Active Properties of Hippocampal CA3 Pyramidal Neuron Dendrites</i>.
    Institute of Science and Technology Austria, 2012.
  short: S. Kim, Active Properties of Hippocampal CA3 Pyramidal Neuron Dendrites,
    Institute of Science and Technology Austria, 2012.
corr_author: '1'
date_created: 2018-12-11T12:00:35Z
date_published: 2012-06-01T00:00:00Z
date_updated: 2026-06-18T18:41:53Z
day: '01'
degree_awarded: PhD
department:
- _id: PeJo
- _id: GradSch
language:
- iso: eng
month: '06'
oa_version: None
page: '65'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '3755'
related_material:
  record:
  - id: '3258'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
title: Active properties of hippocampal CA3 pyramidal neuron dendrites
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2012'
...
---
OA_place: publisher
_id: '3962'
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Holger
  full_name: Pflicke, Holger
  id: CAA57A9A-5B61-11E9-B130-E0C1E1F2C83D
  last_name: Pflicke
citation:
  ama: Pflicke H.   Dendritic cell migration across basement membranes in the skin.
    2010.
  apa: Pflicke, H. (2010). <i>  Dendritic cell migration across basement membranes
    in the skin</i>. Institute of Science and Technology Austria.
  chicago: Pflicke, Holger. “  Dendritic Cell Migration across Basement Membranes
    in the Skin.” Institute of Science and Technology Austria, 2010.
  ieee: H. Pflicke, “  Dendritic cell migration across basement membranes in the skin,”
    Institute of Science and Technology Austria, 2010.
  ista: Pflicke H. 2010.   Dendritic cell migration across basement membranes in the
    skin. Institute of Science and Technology Austria.
  mla: Pflicke, Holger. <i>  Dendritic Cell Migration across Basement Membranes in
    the Skin</i>. Institute of Science and Technology Austria, 2010.
  short: H. Pflicke,   Dendritic Cell Migration across Basement Membranes in the Skin,
    Institute of Science and Technology Austria, 2010.
corr_author: '1'
date_created: 2018-12-11T12:06:08Z
date_published: 2010-07-01T00:00:00Z
date_updated: 2026-04-09T14:37:07Z
day: '01'
degree_awarded: PhD
department:
- _id: CaHe
- _id: GradSch
language:
- iso: eng
month: '07'
oa_version: None
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '2165'
status: public
supervisor:
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
title: "\uFEFF\uFEFFDendritic cell migration across basement membranes in the skin"
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2010'
...