--- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '20963' abstract: - lang: eng text: In all domains of life, tRNAs mediate the transfer of genetic information from mRNAs to proteins. As their depletion suppresses translation and, consequently, viral replication, tRNAs represent long-standing and increasingly recognized targets of innate immunity1,2,3,4,5. Here we report Cas12a3 effector nucleases from type V CRISPR–Cas adaptive immune systems in bacteria that preferentially cleave tRNAs after recognition of target RNA. Cas12a3 orthologues belong to one of two previously unreported nuclease clades that exhibit RNA-mediated cleavage of non-target RNA, and are distinct from all other known type V systems. Through cell-based and biochemical assays and direct RNA sequencing, we demonstrate that recognition of a complementary target RNA by the CRISPR RNA triggers Cas12a3 to cleave the conserved 5′-CCA-3′ tail of diverse tRNAs to drive growth arrest and anti-phage defence. Cryogenic electron microscopy structures further revealed a distinct tRNA-loading domain that positions the tRNA tail in the RuvC active site of the nuclease. By designing synthetic reporters that mimic the tRNA acceptor stem and tail, we expanded the capacity of current CRISPR-based diagnostics for multiplexed RNA detection. Overall, these findings reveal widespread tRNA inactivation as a previously unrecognized CRISPR-based immune strategy that broadens the application space of the existing CRISPR toolbox. acknowledgement: 'We thank Ł. Koziej for processing of the initial cryo-EM datasets, S. Schmelz for support in cryo-EM, A. Gatzemeier for assistance in the purification of dBa1Cas12a3, R. Rarose for support with the in vitro RNA experiments, M. Kaminski for providing purified PsmCas13b protein, L. Schönemann for protein purification, and C. Krempl and S. Backesfor providing the RSV and influenza A transcript-encoding plasmids. This work was supported through funding by the European Research Council (101001394 to S.G.; 865973 and 101158249 to C.L.B.), the R. Gaurth Hansen Family (to R.N.J.), the National Institutes of Health (R35GM138080 to R.N.J.), the PostDoc Plus Program from the Graduate School of Life Sciences at Julius-Maximilians-Universität Würzburg (to O.D.), and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy–The Berlin Mathematics Research Center MATH+ (EXC−2046/1, project ID: 390685689 to M.v.K.). Open access funding provided by Helmholtz-Zentrum für Infektionsforschung GmbH (HZI).' article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Oleg full_name: Dmytrenko, Oleg last_name: Dmytrenko - first_name: Biao full_name: Yuan, Biao last_name: Yuan - first_name: Kadin T. full_name: Crosby, Kadin T. last_name: Crosby - first_name: Max full_name: Krebel, Max last_name: Krebel - first_name: Xiye full_name: Chen, Xiye last_name: Chen - first_name: Jakub S. full_name: Nowak, Jakub S. last_name: Nowak - first_name: Andrzej full_name: Chramiec-Głąbik, Andrzej last_name: Chramiec-Głąbik - first_name: Bamidele full_name: Filani, Bamidele last_name: Filani - first_name: Anne-Sophie full_name: Gribling-Burrer, Anne-Sophie last_name: Gribling-Burrer - first_name: Wiep full_name: van der Toorn, Wiep last_name: van der Toorn - first_name: Max full_name: von Kleist, Max last_name: von Kleist - first_name: Tatjana full_name: Achmedov, Tatjana last_name: Achmedov - first_name: Redmond P. full_name: Smyth, Redmond P. last_name: Smyth - first_name: Sebastian full_name: Glatt, Sebastian last_name: Glatt - first_name: Jack Peter Kelly full_name: Bravo, Jack Peter Kelly id: 96aecfa5-8931-11ee-af30-aa6a5d6eee0e last_name: Bravo orcid: 0000-0003-0456-0753 - first_name: Dirk W. full_name: Heinz, Dirk W. last_name: Heinz - first_name: Ryan N. full_name: Jackson, Ryan N. last_name: Jackson - first_name: Chase L. full_name: Beisel, Chase L. last_name: Beisel citation: ama: Dmytrenko O, Yuan B, Crosby KT, et al. RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity. Nature. 2026. doi:10.1038/s41586-025-09852-9 apa: Dmytrenko, O., Yuan, B., Crosby, K. T., Krebel, M., Chen, X., Nowak, J. S., … Beisel, C. L. (2026). RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-09852-9 chicago: Dmytrenko, Oleg, Biao Yuan, Kadin T. Crosby, Max Krebel, Xiye Chen, Jakub S. Nowak, Andrzej Chramiec-Głąbik, et al. “RNA-Triggered Cas12a3 Cleaves TRNA Tails to Execute Bacterial Immunity.” Nature. Springer Nature, 2026. https://doi.org/10.1038/s41586-025-09852-9. ieee: O. Dmytrenko et al., “RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity,” Nature. Springer Nature, 2026. ista: Dmytrenko O, Yuan B, Crosby KT, Krebel M, Chen X, Nowak JS, Chramiec-Głąbik A, Filani B, Gribling-Burrer A-S, van der Toorn W, von Kleist M, Achmedov T, Smyth RP, Glatt S, Bravo JPK, Heinz DW, Jackson RN, Beisel CL. 2026. RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity. Nature. mla: Dmytrenko, Oleg, et al. “RNA-Triggered Cas12a3 Cleaves TRNA Tails to Execute Bacterial Immunity.” Nature, Springer Nature, 2026, doi:10.1038/s41586-025-09852-9. short: O. Dmytrenko, B. Yuan, K.T. Crosby, M. Krebel, X. Chen, J.S. Nowak, A. Chramiec-Głąbik, B. Filani, A.-S. Gribling-Burrer, W. van der Toorn, M. von Kleist, T. Achmedov, R.P. Smyth, S. Glatt, J.P.K. Bravo, D.W. Heinz, R.N. Jackson, C.L. Beisel, Nature (2026). date_created: 2026-01-08T07:57:17Z date_published: 2026-01-07T00:00:00Z date_updated: 2026-01-12T10:13:56Z day: '07' ddc: - '570' department: - _id: JaBr doi: 10.1038/s41586-025-09852-9 external_id: pmid: - '41501459' has_accepted_license: '1' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1038/s41586-025-09852-9 month: '01' oa: 1 oa_version: Published Version pmid: 1 publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: epub_ahead publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2026' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '21485' abstract: - lang: eng text: Insulating oxides are among the most abundant solid materials in the universe1,2,3. Of the many ways in which they influence natural phenomena, perhaps the most consequential is their capacity to transfer electrical charge during contact4,5,6,7,8,9,10—which occurs even between samples of the same oxide—yet the symmetry-breaking parameter that causes this remains unidentified11,12. Here we show that adventitious carbonaceous molecules adsorbed from the environment are the symmetry-breaking factor in same-material oxide contact electrification (CE). We use acoustic levitation to measure charge exchange between a sphere and a plate composed of identical amorphous silicon dioxide (SiO2). Although charging polarity is random for co-prepared samples, we control it with baking or plasma treatment. Observing the charge-exchange relaxation afterwards, we see dynamics over a timescale of hours and connect this directly to the presence of adventitious carbon with time-of-flight mass spectrometry, low-energy ion scattering and infrared spectroscopy. Going further, we confirm that adventitious carbon can even determine charge exchange among different oxides. Our results identify the symmetry-breaking parameter that causes insulating oxides to exchange charge in settings ranging from desert sands4 to volcanic plumes5,6, while simultaneously highlighting an overlooked factor in CE more broadly. acknowledged_ssus: - _id: M-Shop - _id: NanoFab - _id: ScienComp - _id: LifeSc acknowledgement: This project has received support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 949120) and from the Marie Skłodowska-Curie programme (grant agreement no. 754411). We acknowledge the state of Lower Austria and the European Regional Development Fund under grant no. WST3-F-542638/004-2021. N.M. acknowledges support from grant Fondecyt 1221597. G.G. is a Serra Húnter fellow. This research was supported by the Scientific Service Units of the Institute of Science and Technology Austria through resources provided by the Miba Machine Shop, Nanofabrication Facility, Scientific Computing facility and Lab Support Facility. We thank the Modic group for the use of the Laue camera, T. Zauner for the photography of the experimental set-up and R. Möller for insightful discussions. Open access funding provided by Institute of Science and Technology (IST Austria). article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Galien M full_name: Grosjean, Galien M id: 0C5FDA4A-9CF6-11E9-8939-FF05E6697425 last_name: Grosjean orcid: 0000-0001-5154-417X - first_name: Markus full_name: Ostermann, Markus last_name: Ostermann - first_name: Markus full_name: Sauer, Markus last_name: Sauer - first_name: Michael full_name: Hahn, Michael last_name: Hahn - first_name: Christian M. full_name: Pichler, Christian M. last_name: Pichler - first_name: Florian full_name: Fahrnberger, Florian last_name: Fahrnberger - first_name: Felix full_name: Pertl, Felix id: 6313aec0-15b2-11ec-abd3-ed67d16139af last_name: Pertl orcid: 0000-0003-0463-5794 - first_name: Daniel full_name: Balazs, Daniel id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E last_name: Balazs orcid: 0000-0001-7597-043X - first_name: Mason M. full_name: Link, Mason M. last_name: Link - first_name: Seong H. full_name: Kim, Seong H. last_name: Kim - first_name: Devin L. full_name: Schrader, Devin L. last_name: Schrader - first_name: Adriana full_name: Blanco, Adriana last_name: Blanco - first_name: Francisco full_name: Gracia, Francisco last_name: Gracia - first_name: Nicolás full_name: Mujica, Nicolás last_name: Mujica - first_name: Scott R full_name: Waitukaitis, Scott R id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87 last_name: Waitukaitis orcid: 0000-0002-2299-3176 citation: ama: Grosjean GM, Ostermann M, Sauer M, et al. Adventitious carbon breaks symmetry in oxide contact electrification. Nature. 2026;651(8106):626-631. doi:10.1038/s41586-025-10088-w apa: Grosjean, G. M., Ostermann, M., Sauer, M., Hahn, M., Pichler, C. M., Fahrnberger, F., … Waitukaitis, S. R. (2026). Adventitious carbon breaks symmetry in oxide contact electrification. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-10088-w chicago: Grosjean, Galien M, Markus Ostermann, Markus Sauer, Michael Hahn, Christian M. Pichler, Florian Fahrnberger, Felix Pertl, et al. “Adventitious Carbon Breaks Symmetry in Oxide Contact Electrification.” Nature. Springer Nature, 2026. https://doi.org/10.1038/s41586-025-10088-w. ieee: G. M. Grosjean et al., “Adventitious carbon breaks symmetry in oxide contact electrification,” Nature, vol. 651, no. 8106. Springer Nature, pp. 626–631, 2026. ista: Grosjean GM, Ostermann M, Sauer M, Hahn M, Pichler CM, Fahrnberger F, Pertl F, Balazs D, Link MM, Kim SH, Schrader DL, Blanco A, Gracia F, Mujica N, Waitukaitis SR. 2026. Adventitious carbon breaks symmetry in oxide contact electrification. Nature. 651(8106), 626–631. mla: Grosjean, Galien M., et al. “Adventitious Carbon Breaks Symmetry in Oxide Contact Electrification.” Nature, vol. 651, no. 8106, Springer Nature, 2026, pp. 626–31, doi:10.1038/s41586-025-10088-w. short: G.M. Grosjean, M. Ostermann, M. Sauer, M. Hahn, C.M. Pichler, F. Fahrnberger, F. Pertl, D. Balazs, M.M. Link, S.H. Kim, D.L. Schrader, A. Blanco, F. Gracia, N. Mujica, S.R. Waitukaitis, Nature 651 (2026) 626–631. corr_author: '1' date_created: 2026-03-23T15:04:00Z date_published: 2026-03-18T00:00:00Z date_updated: 2026-04-28T12:06:01Z day: '18' ddc: - '540' department: - _id: ScWa - _id: GradSch - _id: LifeSc doi: 10.1038/s41586-025-10088-w ec_funded: 1 external_id: pmid: - '41851325' file: - access_level: open_access checksum: dafef9ed575b44be4263e948a47ae056 content_type: application/pdf creator: dernst date_created: 2026-03-24T06:57:08Z date_updated: 2026-03-24T06:57:08Z file_id: '21494' file_name: 2026_Nature_Grosjean.pdf file_size: 12245694 relation: main_file success: 1 file_date_updated: 2026-03-24T06:57:08Z has_accepted_license: '1' intvolume: ' 651' issue: '8106' language: - iso: eng month: '03' oa: 1 oa_version: Published Version page: 626-631 pmid: 1 project: - _id: 0aa60e99-070f-11eb-9043-a6de6bdc3afa call_identifier: H2020 grant_number: '949120' name: 'Tribocharge: a multi-scale approach to an enduring problem in physics' - _id: 260C2330-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '754411' name: ISTplus - Postdoctoral Fellowships publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/colliding-dust-and-the-sparks-of-creation/ status: public title: Adventitious carbon breaks symmetry in oxide contact electrification tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 651 year: '2026' ... --- OA_place: repository OA_type: green _id: '21798' abstract: - lang: eng text: 'Phase singularities—points carrying quantized topological charge—are universal features found across diverse wave systems from superfluids and superconductors to acoustic and optical fields1,2,3,4. Ensembles of these singularities exhibit distance correlations resembling particles in liquids5,6,7,8, extensively studied for their role in exotic material phases9,10,11. By contrast, the full correlations in phase space that govern the system evolution have remained unexplored and experimentally inaccessible. Here we directly measure the ultrafast dynamics of optical singularity ensembles, capturing their full phase-space correlations, presenting the joint distance–velocity distribution. Our observations show a breakdown of the particle-singularity analogy12: phase singularities accelerate towards formally divergent velocities in the moment before annihilation7,13,14, indicated by measurements of velocities exceeding the speed of light. These apparent superluminal velocities are paradoxically amplified by the slow group velocity of hyperbolic phonon polaritons in our material platform, hexagonal boron nitride membranes15,16,17,18,19. We demonstrate these phenomena using combined hardware and algorithmic advances in ultrafast electron microscopy18,20,21,22,23,24,25, achieving spatial and temporal resolutions, each an order of magnitude below the polaritonic wavelength and cycle period. Our findings deepen our understanding of phase singularities and their universality, enabling to probe topological defect dynamics at previously unattainable timescales.' article_processing_charge: No article_type: original arxiv: 1 author: - first_name: T. full_name: Bucher, T. last_name: Bucher - first_name: A. full_name: Gorlach, A. last_name: Gorlach - first_name: A. full_name: Niedermayr, A. last_name: Niedermayr - first_name: Q. full_name: Yan, Q. last_name: Yan - first_name: H. full_name: Nahari, H. last_name: Nahari - first_name: K. full_name: Wang, K. last_name: Wang - first_name: R. full_name: Ruimy, R. last_name: Ruimy - first_name: Y. full_name: Adiv, Y. last_name: Adiv - first_name: M. full_name: Yannai, M. last_name: Yannai - first_name: T. L. full_name: Abudi, T. L. last_name: Abudi - first_name: E. full_name: Janzen, E. last_name: Janzen - first_name: C. full_name: Spaegele, C. last_name: Spaegele - first_name: Charles full_name: Roques-Carmes, Charles id: e2e68fc9-6505-11ef-a541-eb4e72cc3e82 last_name: Roques-Carmes - first_name: J. H. full_name: Edgar, J. H. last_name: Edgar - first_name: F. H. L. full_name: Koppens, F. H. L. last_name: Koppens - first_name: G. M. full_name: Vanacore, G. M. last_name: Vanacore - first_name: H. full_name: H. Sheinfux, H. last_name: H. Sheinfux - first_name: S. full_name: Tsesses, S. last_name: Tsesses - first_name: I. full_name: Kaminer, I. last_name: Kaminer citation: ama: Bucher T, Gorlach A, Niedermayr A, et al. Superluminal correlations in ensembles of optical phase singularities. Nature. 2026;651(8107):920-926. doi:10.1038/s41586-026-10209-z apa: Bucher, T., Gorlach, A., Niedermayr, A., Yan, Q., Nahari, H., Wang, K., … Kaminer, I. (2026). Superluminal correlations in ensembles of optical phase singularities. Nature. Springer Nature. https://doi.org/10.1038/s41586-026-10209-z chicago: Bucher, T., A. Gorlach, A. Niedermayr, Q. Yan, H. Nahari, K. Wang, R. Ruimy, et al. “Superluminal Correlations in Ensembles of Optical Phase Singularities.” Nature. Springer Nature, 2026. https://doi.org/10.1038/s41586-026-10209-z. ieee: T. Bucher et al., “Superluminal correlations in ensembles of optical phase singularities,” Nature, vol. 651, no. 8107. Springer Nature, pp. 920–926, 2026. ista: Bucher T, Gorlach A, Niedermayr A, Yan Q, Nahari H, Wang K, Ruimy R, Adiv Y, Yannai M, Abudi TL, Janzen E, Spaegele C, Roques-Carmes C, Edgar JH, Koppens FHL, Vanacore GM, H. Sheinfux H, Tsesses S, Kaminer I. 2026. Superluminal correlations in ensembles of optical phase singularities. Nature. 651(8107), 920–926. mla: Bucher, T., et al. “Superluminal Correlations in Ensembles of Optical Phase Singularities.” Nature, vol. 651, no. 8107, Springer Nature, 2026, pp. 920–26, doi:10.1038/s41586-026-10209-z. short: T. Bucher, A. Gorlach, A. Niedermayr, Q. Yan, H. Nahari, K. Wang, R. Ruimy, Y. Adiv, M. Yannai, T.L. Abudi, E. Janzen, C. Spaegele, C. Roques-Carmes, J.H. Edgar, F.H.L. Koppens, G.M. Vanacore, H. H. Sheinfux, S. Tsesses, I. Kaminer, Nature 651 (2026) 920–926. date_created: 2026-05-05T11:05:31Z date_published: 2026-03-25T00:00:00Z date_updated: 2026-05-05T11:10:07Z day: '25' doi: 10.1038/s41586-026-10209-z extern: '1' external_id: arxiv: - '2509.17675' intvolume: ' 651' issue: '8107' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2509.17675 month: '03' oa: 1 oa_version: Preprint page: 920-926 publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: Superluminal correlations in ensembles of optical phase singularities type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 651 year: '2026' ... --- OA_place: publisher OA_type: hybrid _id: '20101' abstract: - lang: eng text: 'Evading imminent threat from predators is critical for animal survival. Effective defensive strategies can vary, even between closely related species. However, the neural basis of such species-specific behaviours remains poorly understood1,2,3,4. Here we find that two sister species of deer mice (genus Peromyscus)5 show different responses to the same looming stimulus: Peromyscus maniculatus, which occupies densely vegetated habitats, predominantly escapes, whereas the open field specialist, Peromyscus polionotus, briefly freezes. This difference arises from species-specific escape thresholds, is largely context-independent, and can be triggered by both visual and auditory threat stimuli. Using immunohistochemistry and electrophysiological recordings, we find that although visual threat activates the superior colliculus in both species, the role of the dorsal periaqueductal grey (dPAG) in driving behaviour differs. Whereas dPAG activity scales with running speed in P. maniculatus, neural activity in the dPAG of P. polionotus correlates poorly with movement, including during visually triggered escape. Moreover, optogenetic activation of dPAG neurons elicits acceleration in P. maniculatus but not in P. polionotus, and their chemogenetic inhibition during a looming stimulus delays escape onset in P. maniculatus to match that of P. polionotus. Together, we trace species-specific escape thresholds to a central circuit node, downstream of peripheral sensory neurons, localizing an ecologically relevant behavioural difference to a specific region of the mammalian brain.' acknowledgement: The authors thank M. Yilmaz, M. Meister, M. Joesch and T. Branco for advice on the behavioural experiments; C. Dulac, V. Bitsikas, E. Diel and J. Chen for advice on the immunohistochemistry and RNAscope experiments; J. Greenwood and E. Soucy for technical and engineering help; A. Chrzanowska for help and advice on optogenetic experiments; A. Calzoni for help aligning histological sections to a brain atlas; S. Worthington for statistical advice; P. Gonçalves for advice with the electrophysiology analysis; I. Vlaemick for help with whole cell experiments; R. Hellmiss for figure design; B. Sabatini, V. Stempel, K. Tyssowski and N. Sanguinetti for feedback on the manuscript; and Y. M. Lee and A. Tomcho for photos of P. maniculatus and P. leucopus habitats (Fig. 1). F.B. was supported by an HHMI International Student Research Fellowship, a Grant-in-Aid of the American Society of Mammalogy, a Herchel Smith Graduate Fellowship, a Robert A. Chapman Memorial Scholarship, and a Joan Brockman Williamson Fellowship. This project received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement 665501 and by the FWO (12S7917N and 12S7920N) to K.R. and from European Research Council (ERC) (grant agreement 101075848) to K.R. V.T. was supported by a Harvard PRISE fellowship and a Harvard Museum of Comparative Zoology grant for undergraduate research. K.F. is supported by the FWO (G094616N and G091719N) and the NIH (1R01EY032101). This work was supported by the Howard Hughes Medical Institute, of which H.E.H. was an Investigator. article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Felix full_name: Baier, Felix last_name: Baier - first_name: Katja full_name: Reinhard, Katja last_name: Reinhard - first_name: Bram full_name: Nuttin, Bram last_name: Nuttin - first_name: Arnau full_name: Sans-Dublanc, Arnau last_name: Sans-Dublanc - first_name: Chen full_name: Liu, Chen last_name: Liu - first_name: Victoria full_name: Tong, Victoria last_name: Tong - first_name: Julie Stefanie full_name: Murmann, Julie Stefanie id: 1d390868-f128-11eb-9611-a0ca5f7833b5 last_name: Murmann - first_name: Keimpe full_name: Wierda, Keimpe last_name: Wierda - first_name: Karl full_name: Farrow, Karl last_name: Farrow - first_name: Hopi E. full_name: Hoekstra, Hopi E. last_name: Hoekstra citation: ama: Baier F, Reinhard K, Nuttin B, et al. The neural basis of species-specific defensive behaviour in Peromyscus mice. Nature. 2025;645:439-447. doi:10.1038/s41586-025-09241-2 apa: Baier, F., Reinhard, K., Nuttin, B., Sans-Dublanc, A., Liu, C., Tong, V., … Hoekstra, H. E. (2025). The neural basis of species-specific defensive behaviour in Peromyscus mice. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-09241-2 chicago: Baier, Felix, Katja Reinhard, Bram Nuttin, Arnau Sans-Dublanc, Chen Liu, Victoria Tong, Julie Stefanie Murmann, Keimpe Wierda, Karl Farrow, and Hopi E. Hoekstra. “The Neural Basis of Species-Specific Defensive Behaviour in Peromyscus Mice.” Nature. Springer Nature, 2025. https://doi.org/10.1038/s41586-025-09241-2. ieee: F. Baier et al., “The neural basis of species-specific defensive behaviour in Peromyscus mice,” Nature, vol. 645. Springer Nature, pp. 439–447, 2025. ista: Baier F, Reinhard K, Nuttin B, Sans-Dublanc A, Liu C, Tong V, Murmann JS, Wierda K, Farrow K, Hoekstra HE. 2025. The neural basis of species-specific defensive behaviour in Peromyscus mice. Nature. 645, 439–447. mla: Baier, Felix, et al. “The Neural Basis of Species-Specific Defensive Behaviour in Peromyscus Mice.” Nature, vol. 645, Springer Nature, 2025, pp. 439–47, doi:10.1038/s41586-025-09241-2. short: F. Baier, K. Reinhard, B. Nuttin, A. Sans-Dublanc, C. Liu, V. Tong, J.S. Murmann, K. Wierda, K. Farrow, H.E. Hoekstra, Nature 645 (2025) 439–447. date_created: 2025-08-03T22:01:31Z date_published: 2025-07-23T00:00:00Z date_updated: 2026-01-05T11:38:40Z day: '23' ddc: - '570' department: - _id: GradSch doi: 10.1038/s41586-025-09241-2 external_id: pmid: - '40702175' file: - access_level: open_access checksum: 7ea846a7a49b3b2a248f6a27ab13d591 content_type: application/pdf creator: dernst date_created: 2025-12-30T07:39:45Z date_updated: 2025-12-30T07:39:45Z file_id: '20884' file_name: 2025_Nature_Baier.pdf file_size: 53301589 relation: main_file success: 1 file_date_updated: 2025-12-30T07:39:45Z has_accepted_license: '1' intvolume: ' 645' language: - iso: eng month: '07' oa: 1 oa_version: Published Version page: 439-447 pmid: 1 publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: record: - id: '20883' relation: research_data status: public scopus_import: '1' status: public title: The neural basis of species-specific defensive behaviour in Peromyscus mice tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 645 year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '20430' abstract: - lang: eng text: Protein design has focused on the design of ground states, ensuring that they are sufficiently low energy to be highly populated1. Designing the kinetics and dynamics of a system requires, in addition, the design of excited states that are traversed in transitions from one low-lying state to another2,3. This is a challenging task because such states must be sufficiently strained to be poorly populated, but not so strained that they are not populated at all, and because protein design methods have focused on generating near-ideal structures4,5,6,7. Here we describe a general approach for designing systems that use an induced-fit power stroke8 to generate a structurally frustrated9 and strained excited state, allosterically driving protein complex dissociation. X-ray crystallography, double electron–electron resonance spectroscopy and kinetic binding measurements show that incorporating excited states enables the design of effector-induced increases in dissociation rates as high as 5,700-fold. We highlight the power of this approach by designing rapid biosensors, kinetically controlled circuits and cytokine mimics that can be dissociated from their receptors within seconds, enabling dissection of the temporal dynamics of interleukin-2 signalling. acknowledgement: We thank P. J. Y. Leung, K. L. Shelley, A. Pillai, C. Demakis, M. Exposit, K. Thompson, C. Savvides, R. J. Ragotte, G. Ahn and M. Glögl for discussions and technical support; K. VanWormer and L. Goldschmidt for technical support; S. R. Gerben and A. Murray for protein production support; and X. Li, M. Lamb, Z. Taylor and V. Adebomi for LC–MS support. This work was supported by the Audacious Project at the Institute for Protein Design (A.J.B., A.K., J.D.L.C., E.B. and A.K.B.); by a gift from Microsoft (A.J.B.); by the Nordstrom Barrier Institute for Protein Design Directors Fund (M.H.A. and F.P.); by Bill and Melinda Gates Foundation OPP1156262 (A.K. and J.D.L.C.); by the Open Philanthropy Project Improving Protein Design Fund (E.B. and A.K.B.); by the National Institutes of Health (NIH) National Institute of Allergy and Infectious Disease grant R0AI160052 (A.K.B.); by CRI Irvington Postdoctoral Fellowship 315511 (Y.Z.); by National Cancer Institute K00 award 4K00CA274708 (M.O.); by National Science Foundation grant MCB 2119837 and NIH grant GM115805 (W.H.R. and D.M.Z.); by NIH grant GM151956 (S.S.); by NIH AI-51321 (K.C.G.); by the DFG grants PI 405/15 and SFB 1557 (C.P. and J.P.); and by the Howard Hughes Medical Institute (A.K.B., K.C.G. and D.B.). The EPR spectrometer used for the DEER experiments was in part supported by NIH grant S10OD021557. This research used resources (FMX/AMX) of the National Synchrotron Light Source II, a US Department of Energy (DoE) Office of Science User Facility operated for the DOE Office of Science by Brookhaven National Laboratory under contract DE-SC0012704. The Center for BioMolecular Structure (CBMS) is supported mainly by the NIH National Institute of General Medical Sciences (NIGMS) through a Center Core P30 Grant (P30GM133893), and by the DoE Office of Biological and Environmental Research (KP1607011). This work is based on research performed at the Northeastern Collaborative Access Team beamlines, which are funded by the NIGMS (P30 GM124165). The research used resources of the Advanced Photon Source, a US DoE Office of Science User Facility operated for the DoE Office of Science by Argonne National Laboratory under contract DE-AC02-06CH11357. The Berkeley Center for Structural Biology is supported by the NIH, NIGMS and the Howard Hughes Medical Institute. The Advanced Light Source is supported by the Director, Office of Science, Office of Basic Energy Sciences and US DoE (DE-AC02-05CH11231). article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Adam J. full_name: Broerman, Adam J. last_name: Broerman - first_name: Christoph full_name: Pollmann, Christoph last_name: Pollmann - first_name: Yang full_name: Zhao, Yang last_name: Zhao - first_name: Mauriz A. full_name: Lichtenstein, Mauriz A. last_name: Lichtenstein - first_name: Mark D. full_name: Jackson, Mark D. last_name: Jackson - first_name: Maxx H. full_name: Tessmer, Maxx H. last_name: Tessmer - first_name: Won Hee full_name: Ryu, Won Hee last_name: Ryu - first_name: Masato full_name: Ogishi, Masato last_name: Ogishi - first_name: Mohamad H. full_name: Abedi, Mohamad H. last_name: Abedi - first_name: Danny D. full_name: Sahtoe, Danny D. last_name: Sahtoe - first_name: Aza full_name: Allen, Aza last_name: Allen - first_name: Alex full_name: Kang, Alex last_name: Kang - first_name: Joshmyn full_name: De La Cruz, Joshmyn last_name: De La Cruz - first_name: Evans full_name: Brackenbrough, Evans last_name: Brackenbrough - first_name: Banumathi full_name: Sankaran, Banumathi last_name: Sankaran - first_name: Asim K. full_name: Bera, Asim K. last_name: Bera - first_name: Daniel M. full_name: Zuckerman, Daniel M. last_name: Zuckerman - first_name: Stefan full_name: Stoll, Stefan last_name: Stoll - first_name: K. Christopher full_name: Garcia, K. Christopher last_name: Garcia - first_name: Florian M full_name: Praetorius, Florian M id: dfec9381-4341-11ee-8fd8-faa02bba7d62 last_name: Praetorius orcid: 0000-0002-0806-8101 - first_name: Jacob full_name: Piehler, Jacob last_name: Piehler - first_name: David full_name: Baker, David last_name: Baker citation: ama: Broerman AJ, Pollmann C, Zhao Y, et al. Design of facilitated dissociation enables timing of cytokine signalling. Nature. 2025;647:528-535. doi:10.1038/s41586-025-09549-z apa: Broerman, A. J., Pollmann, C., Zhao, Y., Lichtenstein, M. A., Jackson, M. D., Tessmer, M. H., … Baker, D. (2025). Design of facilitated dissociation enables timing of cytokine signalling. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-09549-z chicago: Broerman, Adam J., Christoph Pollmann, Yang Zhao, Mauriz A. Lichtenstein, Mark D. Jackson, Maxx H. Tessmer, Won Hee Ryu, et al. “Design of Facilitated Dissociation Enables Timing of Cytokine Signalling.” Nature. Springer Nature, 2025. https://doi.org/10.1038/s41586-025-09549-z. ieee: A. J. Broerman et al., “Design of facilitated dissociation enables timing of cytokine signalling,” Nature, vol. 647. Springer Nature, pp. 528–535, 2025. ista: Broerman AJ, Pollmann C, Zhao Y, Lichtenstein MA, Jackson MD, Tessmer MH, Ryu WH, Ogishi M, Abedi MH, Sahtoe DD, Allen A, Kang A, De La Cruz J, Brackenbrough E, Sankaran B, Bera AK, Zuckerman DM, Stoll S, Garcia KC, Praetorius FM, Piehler J, Baker D. 2025. Design of facilitated dissociation enables timing of cytokine signalling. Nature. 647, 528–535. mla: Broerman, Adam J., et al. “Design of Facilitated Dissociation Enables Timing of Cytokine Signalling.” Nature, vol. 647, Springer Nature, 2025, pp. 528–35, doi:10.1038/s41586-025-09549-z. short: A.J. Broerman, C. Pollmann, Y. Zhao, M.A. Lichtenstein, M.D. Jackson, M.H. Tessmer, W.H. Ryu, M. Ogishi, M.H. Abedi, D.D. Sahtoe, A. Allen, A. Kang, J. De La Cruz, E. Brackenbrough, B. Sankaran, A.K. Bera, D.M. Zuckerman, S. Stoll, K.C. Garcia, F.M. Praetorius, J. Piehler, D. Baker, Nature 647 (2025) 528–535. corr_author: '1' date_created: 2025-10-05T22:01:36Z date_published: 2025-11-13T00:00:00Z date_updated: 2026-01-05T13:18:17Z day: '13' ddc: - '570' department: - _id: FlPr doi: 10.1038/s41586-025-09549-z external_id: isi: - '001577755600001' pmid: - '40993395' file: - access_level: open_access checksum: b4ec44134e2eb320a724dc29158dfda2 content_type: application/pdf creator: dernst date_created: 2026-01-05T13:17:47Z date_updated: 2026-01-05T13:17:47Z file_id: '20951' file_name: 2025_Nature_Broerman.pdf file_size: 22099921 relation: main_file success: 1 file_date_updated: 2026-01-05T13:17:47Z has_accepted_license: '1' intvolume: ' 647' isi: 1 language: - iso: eng month: '11' oa: 1 oa_version: Published Version page: 528-535 pmid: 1 publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: Design of facilitated dissociation enables timing of cytokine signalling tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 647 year: '2025' ... --- OA_type: closed access _id: '19444' abstract: - lang: eng text: As the field of neural organoids and assembloids expands, there is an emergent need for guidance and advice on designing, conducting and reporting experiments to increase the reproducibility and utility of these models. In this Perspective, we present a framework for the experimental process that encompasses ensuring the quality and integrity of human pluripotent stem cells, characterizing and manipulating neural cells in vitro, transplantation techniques and considerations for modelling human development, evolution and disease. As with all scientific endeavours, we advocate for rigorous experimental designs tailored to explicit scientific questions as well as transparent methodologies and data sharing to provide useful knowledge for current research practices and for developing regulatory standards. acknowledgement: The authors thank members of their laboratories who provided feedback on earlier versions of this manuscript, including A. Jourdon, V. Mariano, T. L. Li, N. Caporale, E. Villa and M. Sutcliffe. article_processing_charge: No article_type: original author: - first_name: Sergiu P. full_name: Pașca, Sergiu P. last_name: Pașca - first_name: Paola full_name: Arlotta, Paola last_name: Arlotta - first_name: Helen S. full_name: Bateup, Helen S. last_name: Bateup - first_name: J. Gray full_name: Camp, J. Gray last_name: Camp - first_name: Silvia full_name: Cappello, Silvia last_name: Cappello - first_name: Fred H. full_name: Gage, Fred H. last_name: Gage - first_name: Jürgen A. full_name: Knoblich, Jürgen A. last_name: Knoblich - first_name: Arnold R. full_name: Kriegstein, Arnold R. last_name: Kriegstein - first_name: Madeline A. full_name: Lancaster, Madeline A. last_name: Lancaster - first_name: Guo Li full_name: Ming, Guo Li last_name: Ming - first_name: Gaia full_name: Novarino, Gaia id: 3E57A680-F248-11E8-B48F-1D18A9856A87 last_name: Novarino orcid: 0000-0002-7673-7178 - first_name: Hideyuki full_name: Okano, Hideyuki last_name: Okano - first_name: Malin full_name: Parmar, Malin last_name: Parmar - first_name: In Hyun full_name: Park, In Hyun last_name: Park - first_name: Orly full_name: Reiner, Orly last_name: Reiner - first_name: Hongjun full_name: Song, Hongjun last_name: Song - first_name: Lorenz full_name: Studer, Lorenz last_name: Studer - first_name: Jun full_name: Takahashi, Jun last_name: Takahashi - first_name: Sally full_name: Temple, Sally last_name: Temple - first_name: Giuseppe full_name: Testa, Giuseppe last_name: Testa - first_name: Barbara full_name: Treutlein, Barbara last_name: Treutlein - first_name: Flora M. full_name: Vaccarino, Flora M. last_name: Vaccarino - first_name: Pierre full_name: Vanderhaeghen, Pierre last_name: Vanderhaeghen - first_name: Tracy full_name: Young-Pearse, Tracy last_name: Young-Pearse citation: ama: Pașca SP, Arlotta P, Bateup HS, et al. A framework for neural organoids, assembloids and transplantation studies. Nature. 2025;639(8054):315-320. doi:10.1038/s41586-024-08487-6 apa: Pașca, S. P., Arlotta, P., Bateup, H. S., Camp, J. G., Cappello, S., Gage, F. H., … Young-Pearse, T. (2025). A framework for neural organoids, assembloids and transplantation studies. Nature. Springer Nature. https://doi.org/10.1038/s41586-024-08487-6 chicago: Pașca, Sergiu P., Paola Arlotta, Helen S. Bateup, J. Gray Camp, Silvia Cappello, Fred H. Gage, Jürgen A. Knoblich, et al. “A Framework for Neural Organoids, Assembloids and Transplantation Studies.” Nature. Springer Nature, 2025. https://doi.org/10.1038/s41586-024-08487-6. ieee: S. P. Pașca et al., “A framework for neural organoids, assembloids and transplantation studies,” Nature, vol. 639, no. 8054. Springer Nature, pp. 315–320, 2025. ista: Pașca SP, Arlotta P, Bateup HS, Camp JG, Cappello S, Gage FH, Knoblich JA, Kriegstein AR, Lancaster MA, Ming GL, Novarino G, Okano H, Parmar M, Park IH, Reiner O, Song H, Studer L, Takahashi J, Temple S, Testa G, Treutlein B, Vaccarino FM, Vanderhaeghen P, Young-Pearse T. 2025. A framework for neural organoids, assembloids and transplantation studies. Nature. 639(8054), 315–320. mla: Pașca, Sergiu P., et al. “A Framework for Neural Organoids, Assembloids and Transplantation Studies.” Nature, vol. 639, no. 8054, Springer Nature, 2025, pp. 315–20, doi:10.1038/s41586-024-08487-6. short: S.P. Pașca, P. Arlotta, H.S. Bateup, J.G. Camp, S. Cappello, F.H. Gage, J.A. Knoblich, A.R. Kriegstein, M.A. Lancaster, G.L. Ming, G. Novarino, H. Okano, M. Parmar, I.H. Park, O. Reiner, H. Song, L. Studer, J. Takahashi, S. Temple, G. Testa, B. Treutlein, F.M. Vaccarino, P. Vanderhaeghen, T. Young-Pearse, Nature 639 (2025) 315–320. date_created: 2025-03-23T23:01:27Z date_published: 2025-03-13T00:00:00Z date_updated: 2025-09-30T11:13:47Z day: '13' department: - _id: GaNo doi: 10.1038/s41586-024-08487-6 external_id: isi: - '001437461900001' pmid: - '39653126' intvolume: ' 639' isi: 1 issue: '8054' language: - iso: eng month: '03' oa_version: None page: 315-320 pmid: 1 publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: A framework for neural organoids, assembloids and transplantation studies type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 639 year: '2025' ... --- OA_place: repository OA_type: green _id: '21548' abstract: - lang: eng text: "Non-Abelian gauge fields provide a conceptual framework to describe particles\r\nhaving spins, underlying many phenomena in electrodynamics, condensed-matter\r\nphysics and particle physics. Lattice models of non-Abelian gauge fields allow us\r\nto understand their physical implications in extended systems. The theoretical\r\nimportance of non-Abelian lattice gauge fields motivates their experimental synthesis\r\nand explorations. Photons are fundamental particles for which artificial gauge fields\r\ncan be synthesized, yet the demonstration of non-Abelian lattice gauge fields for\r\nphotons has not been achieved. Here we demonstrate SU(2) lattice gauge fields for\r\nphotons in the synthetic frequency dimensions, a playground to study lattice\r\nphysics in a scalable and programmable way. In our lattice model, we theoretically\r\nobserve that homogeneous non-Abelian lattice gauge potentials induce Dirac cones\r\nat time-reversal-invariant momenta in the Brillouin zone. We experimentally confirm\r\nthe presence of non-Abelian lattice gauge fields by two signatures: linear band\r\ncrossings at the Dirac cones, and the associated direction reversal of eigenstate\r\ntrajectories. We further demonstrate a non-Abelian scalar lattice gauge potential that\r\nlifts the degeneracies of the Dirac cones. Our results highlight the implications of\r\nnon-Abelian lattice gauge fields in topological physics, and provide a starting point\r\nfor demonstrations of emerging non-Abelian physics in the photonic synthetic\r\ndimensions. Our results may also benefit photonic technologies by providing controls\r\nof photon spins and pseudo-spins in topologically non-trivial ways." article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Dali full_name: Cheng, Dali last_name: Cheng - first_name: Kai full_name: Wang, Kai last_name: Wang - first_name: Charles full_name: Roques-Carmes, Charles id: e2e68fc9-6505-11ef-a541-eb4e72cc3e82 last_name: Roques-Carmes - first_name: Eran full_name: Lustig, Eran last_name: Lustig - first_name: Olivia Y. full_name: Long, Olivia Y. last_name: Long - first_name: Heming full_name: Wang, Heming last_name: Wang - first_name: Shanhui full_name: Fan, Shanhui last_name: Fan citation: ama: Cheng D, Wang K, Roques-Carmes C, et al. Non-Abelian lattice gauge fields in photonic synthetic frequency dimensions. Nature. 2025;637(8044):52-56. doi:10.1038/s41586-024-08259-2 apa: Cheng, D., Wang, K., Roques-Carmes, C., Lustig, E., Long, O. Y., Wang, H., & Fan, S. (2025). Non-Abelian lattice gauge fields in photonic synthetic frequency dimensions. Nature. Springer Nature. https://doi.org/10.1038/s41586-024-08259-2 chicago: Cheng, Dali, Kai Wang, Charles Roques-Carmes, Eran Lustig, Olivia Y. Long, Heming Wang, and Shanhui Fan. “Non-Abelian Lattice Gauge Fields in Photonic Synthetic Frequency Dimensions.” Nature. Springer Nature, 2025. https://doi.org/10.1038/s41586-024-08259-2. ieee: D. Cheng et al., “Non-Abelian lattice gauge fields in photonic synthetic frequency dimensions,” Nature, vol. 637, no. 8044. Springer Nature, pp. 52–56, 2025. ista: Cheng D, Wang K, Roques-Carmes C, Lustig E, Long OY, Wang H, Fan S. 2025. Non-Abelian lattice gauge fields in photonic synthetic frequency dimensions. Nature. 637(8044), 52–56. mla: Cheng, Dali, et al. “Non-Abelian Lattice Gauge Fields in Photonic Synthetic Frequency Dimensions.” Nature, vol. 637, no. 8044, Springer Nature, 2025, pp. 52–56, doi:10.1038/s41586-024-08259-2. short: D. Cheng, K. Wang, C. Roques-Carmes, E. Lustig, O.Y. Long, H. Wang, S. Fan, Nature 637 (2025) 52–56. date_created: 2026-03-30T12:22:47Z date_published: 2025-01-02T00:00:00Z date_updated: 2026-04-27T07:14:06Z day: '02' ddc: - '530' doi: 10.1038/s41586-024-08259-2 extern: '1' external_id: arxiv: - '2406.00321' pmid: - '39743600' intvolume: ' 637' issue: '8044' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2406.00321 month: '01' oa: 1 oa_version: Preprint page: 52-56 pmid: 1 publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: Non-Abelian lattice gauge fields in photonic synthetic frequency dimensions type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 637 year: '2025' ... --- OA_place: publisher OA_type: hybrid _id: '21549' abstract: - lang: eng text: Integrated photonics, particularly silicon photonics, have emerged as cutting-edge technology driven by promising applications such as short-reach communications, autonomous driving, biosensing and photonic computing1,2,3,4. As advances in AI lead to growing computing demands, photonic computing has gained considerable attention as an appealing candidate. Nonetheless, there are substantial technical challenges in the scaling up of integrated photonics systems to realize these advantages, such as ensuring consistent performance gains in upscaled integrated device clusters, establishing standard designs and verification processes for complex circuits, as well as packaging large-scale systems. These obstacles arise primarily because of the relative immaturity of integrated photonics manufacturing and the scarcity of advanced packaging solutions involving photonics. Here we report a large-scale integrated photonic accelerator comprising more than 16,000 photonic components. The accelerator is designed to deliver standard linear matrix multiply–accumulate (MAC) functions, enabling computing with high speed up to 1 GHz frequency and low latency as small as 3 ns per cycle. Logic, memory and control functions that support photonic matrix MAC operations were designed into a cointegrated electronics chip. To seamlessly integrate the electronics and photonics chips at the commercial scale, we have made use of an innovative 2.5D hybrid advanced packaging approach. Through the development of this accelerator system, we demonstrate an ultralow computation latency for heuristic solvers of computationally hard Ising problems whose performance greatly relies on the computing latency. article_processing_charge: No article_type: original author: - first_name: Shiyue full_name: Hua, Shiyue last_name: Hua - first_name: Erwan full_name: Divita, Erwan last_name: Divita - first_name: Shanshan full_name: Yu, Shanshan last_name: Yu - first_name: Bo full_name: Peng, Bo last_name: Peng - first_name: Charles full_name: Roques-Carmes, Charles id: e2e68fc9-6505-11ef-a541-eb4e72cc3e82 last_name: Roques-Carmes - first_name: Zhan full_name: Su, Zhan last_name: Su - first_name: Zhang full_name: Chen, Zhang last_name: Chen - first_name: Yanfei full_name: Bai, Yanfei last_name: Bai - first_name: Jinghui full_name: Zou, Jinghui last_name: Zou - first_name: Yunpeng full_name: Zhu, Yunpeng last_name: Zhu - first_name: Yelong full_name: Xu, Yelong last_name: Xu - first_name: Cheng-kuan full_name: Lu, Cheng-kuan last_name: Lu - first_name: Yuemiao full_name: Di, Yuemiao last_name: Di - first_name: Hui full_name: Chen, Hui last_name: Chen - first_name: Lushan full_name: Jiang, Lushan last_name: Jiang - first_name: Lijie full_name: Wang, Lijie last_name: Wang - first_name: Longwu full_name: Ou, Longwu last_name: Ou - first_name: Chaohong full_name: Zhang, Chaohong last_name: Zhang - first_name: Junjie full_name: Chen, Junjie last_name: Chen - first_name: Wen full_name: Zhang, Wen last_name: Zhang - first_name: Hongyan full_name: Zhu, Hongyan last_name: Zhu - first_name: Weijun full_name: Kuang, Weijun last_name: Kuang - first_name: Long full_name: Wang, Long last_name: Wang - first_name: Huaiyu full_name: Meng, Huaiyu last_name: Meng - first_name: Maurice full_name: Steinman, Maurice last_name: Steinman - first_name: Yichen full_name: Shen, Yichen last_name: Shen citation: ama: Hua S, Divita E, Yu S, et al. An integrated large-scale photonic accelerator with ultralow latency. Nature. 2025;640:361-367. doi:10.1038/s41586-025-08786-6 apa: Hua, S., Divita, E., Yu, S., Peng, B., Roques-Carmes, C., Su, Z., … Shen, Y. (2025). An integrated large-scale photonic accelerator with ultralow latency. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-08786-6 chicago: Hua, Shiyue, Erwan Divita, Shanshan Yu, Bo Peng, Charles Roques-Carmes, Zhan Su, Zhang Chen, et al. “An Integrated Large-Scale Photonic Accelerator with Ultralow Latency.” Nature. Springer Nature, 2025. https://doi.org/10.1038/s41586-025-08786-6. ieee: S. Hua et al., “An integrated large-scale photonic accelerator with ultralow latency,” Nature, vol. 640. Springer Nature, pp. 361–367, 2025. ista: Hua S, Divita E, Yu S, Peng B, Roques-Carmes C, Su Z, Chen Z, Bai Y, Zou J, Zhu Y, Xu Y, Lu C, Di Y, Chen H, Jiang L, Wang L, Ou L, Zhang C, Chen J, Zhang W, Zhu H, Kuang W, Wang L, Meng H, Steinman M, Shen Y. 2025. An integrated large-scale photonic accelerator with ultralow latency. Nature. 640, 361–367. mla: Hua, Shiyue, et al. “An Integrated Large-Scale Photonic Accelerator with Ultralow Latency.” Nature, vol. 640, Springer Nature, 2025, pp. 361–67, doi:10.1038/s41586-025-08786-6. short: S. Hua, E. Divita, S. Yu, B. Peng, C. Roques-Carmes, Z. Su, Z. Chen, Y. Bai, J. Zou, Y. Zhu, Y. Xu, C. Lu, Y. Di, H. Chen, L. Jiang, L. Wang, L. Ou, C. Zhang, J. Chen, W. Zhang, H. Zhu, W. Kuang, L. Wang, H. Meng, M. Steinman, Y. Shen, Nature 640 (2025) 361–367. date_created: 2026-03-30T12:22:47Z date_published: 2025-04-09T00:00:00Z date_updated: 2026-04-27T08:38:44Z day: '09' ddc: - '530' doi: 10.1038/s41586-025-08786-6 extern: '1' external_id: pmid: - ' 40205213' intvolume: ' 640' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1038/s41586-025-08786-6 month: '04' oa: 1 oa_version: Published Version page: 361-367 pmid: 1 publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: An integrated large-scale photonic accelerator with ultralow latency tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 640 year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '17468' abstract: - lang: eng text: Oxygen redox chemistry is central to life1 and many human-made technologies, such as in energy storage2,3,4. The large energy gain from oxygen redox reactions is often connected with the occurrence of harmful reactive oxygen species3,5,6. Key species are superoxide and the highly reactive singlet oxygen3,4,5,6,7, which may evolve from superoxide. However, the factors determining the formation of singlet oxygen, rather than the relatively unreactive triplet oxygen, are unknown. Here we report that the release of triplet or singlet oxygen is governed by individual Marcus normal and inverted region behaviour. We found that as the driving force for the reaction increases, the initially dominant evolution of triplet oxygen slows down, and singlet oxygen evolution becomes predominant with higher maximum kinetics. This behaviour also applies to the widely observed superoxide disproportionation, in which one superoxide is oxidized by another, in both non-aqueous and aqueous systems, with Lewis and Brønsted acidity controlling the driving forces. Singlet oxygen yields governed by these conditions are relevant, for example, in batteries or cellular organelles in which superoxide forms. Our findings suggest ways to understand and control spin states and kinetics in oxygen redox chemistry, with implications for fields, including life sciences, pure chemistry and energy storage. acknowledged_ssus: - _id: Bio - _id: LifeSc - _id: M-Shop - _id: ScienComp acknowledgement: S.A.F. thanks the Institute of Science and Technology Austria (ISTA) for the support. The Scientific Service Units of ISTA supported this research through resources provided by the Imaging and Optics Facility, the Lab Support Facility, the Miba Machine Shop and Scientific Computing. This research was partly funded by the Austrian Science Fund (FWF) (10.55776/P37169 and 10.55776/COE5). For open access purposes, the author has applied for a CC BY public copyright licence to any author-accepted manuscript version arising from this submission. R.H. acknowledges funding through CZI grant DAF2020-225401 (10.37921/120055ratwvi) from the Chan Zuckerberg Initiative DAF, an advised fund of Silicon Valley Community Foundation (10.13039/100014989). H.T.K.N. acknowledges funding by the European Commission Erasmus Mundus Joint Masters programme. We thank M. Sixt and M. Chinon for the discussions about O-redox in life and R. Jethwa for proofreading. Open access funding was provided by ISTA. article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Soumyadip full_name: Mondal, Soumyadip id: d25d21ef-dc8d-11ea-abe3-ec4576307f48 last_name: Mondal - first_name: Huyen T.K. full_name: Nguyen, Huyen T.K. last_name: Nguyen - first_name: Robert full_name: Hauschild, Robert id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87 last_name: Hauschild orcid: 0000-0001-9843-3522 - first_name: Stefan Alexander full_name: Freunberger, Stefan Alexander id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425 last_name: Freunberger orcid: 0000-0003-2902-5319 citation: ama: Mondal S, Nguyen HTK, Hauschild R, Freunberger SA. Marcus kinetics control singlet and triplet oxygen evolving from superoxide. Nature. 2025;646(8085):601–605. doi:10.1038/s41586-025-09587-7 apa: Mondal, S., Nguyen, H. T. K., Hauschild, R., & Freunberger, S. A. (2025). Marcus kinetics control singlet and triplet oxygen evolving from superoxide. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-09587-7 chicago: Mondal, Soumyadip, Huyen T.K. Nguyen, Robert Hauschild, and Stefan Alexander Freunberger. “Marcus Kinetics Control Singlet and Triplet Oxygen Evolving from Superoxide.” Nature. Springer Nature, 2025. https://doi.org/10.1038/s41586-025-09587-7. ieee: S. Mondal, H. T. K. Nguyen, R. Hauschild, and S. A. Freunberger, “Marcus kinetics control singlet and triplet oxygen evolving from superoxide,” Nature, vol. 646, no. 8085. Springer Nature, pp. 601–605, 2025. ista: Mondal S, Nguyen HTK, Hauschild R, Freunberger SA. 2025. Marcus kinetics control singlet and triplet oxygen evolving from superoxide. Nature. 646(8085), 601–605. mla: Mondal, Soumyadip, et al. “Marcus Kinetics Control Singlet and Triplet Oxygen Evolving from Superoxide.” Nature, vol. 646, no. 8085, Springer Nature, 2025, pp. 601–605, doi:10.1038/s41586-025-09587-7. short: S. Mondal, H.T.K. Nguyen, R. Hauschild, S.A. Freunberger, Nature 646 (2025) 601–605. corr_author: '1' date_created: 2024-08-29T10:40:23Z date_published: 2025-10-16T00:00:00Z date_updated: 2026-04-28T13:18:33Z day: '16' ddc: - '540' department: - _id: StFr - _id: Bio doi: 10.1038/s41586-025-09587-7 external_id: isi: - '001586378900001' pmid: - '41044415' file: - access_level: open_access checksum: b507ddd23df0388aa65d04dc9b00fe3d content_type: application/pdf creator: dernst date_created: 2025-10-20T10:26:13Z date_updated: 2025-10-20T10:26:13Z file_id: '20500' file_name: 2025_Nature_Mondal.pdf file_size: 3809247 relation: main_file success: 1 file_date_updated: 2025-10-20T10:26:13Z has_accepted_license: '1' intvolume: ' 646' isi: 1 issue: '8085' language: - iso: eng month: '10' oa: 1 oa_version: Published Version page: 601–605 pmid: 1 project: - _id: 8df062be-16d5-11f0-9cad-f559b6612c7e grant_number: P37169 name: Singlet oxygen in non-aqueous oxygen redox chemistry - _id: c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473 grant_number: CZI01 name: Tools for automation and feedback microscopy publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/taming-the-bad-oxygen/ scopus_import: '1' status: public title: Marcus kinetics control singlet and triplet oxygen evolving from superoxide tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 646 year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '19704' abstract: - lang: eng text: The information-processing capability of the brain’s cellular network depends on the physical wiring pattern between neurons and their molecular and functional characteristics. Mapping neurons and resolving their individual synaptic connections can be achieved by volumetric imaging at nanoscale resolution1,2 with dense cellular labelling. Light microscopy is uniquely positioned to visualize specific molecules, but dense, synapse-level circuit reconstruction by light microscopy has been out of reach, owing to limitations in resolution, contrast and volumetric imaging capability. Here we describe light-microscopy-based connectomics (LICONN). We integrated specifically engineered hydrogel embedding and expansion with comprehensive deep-learning-based segmentation and analysis of connectivity, thereby directly incorporating molecular information into synapse-level reconstructions of brain tissue. LICONN will allow synapse-level phenotyping of brain tissue in biological experiments in a readily adoptable manner. acknowledged_ssus: - _id: Bio - _id: LifeSc - _id: ScienComp - _id: PreCl - _id: M-Shop - _id: E-Lib acknowledgement: 'We thank S. Dorkenwald and P. Li for critical reading of the manuscript, S. Loomba for discussions and E. Miguel for support with data handling. We acknowledge support from ISTA’s scientific service units: Imaging and Optics, Lab Support, Scientific Computing, the preclinical facility, the Miba Machine Shop and the library. We acknowledge funding from the following sources: Austrian Science Fund (FWF) grant DK W1232 (J.G.D. and M.R.T.); Austrian Academy of Sciences DOC fellowship 26137 (M.R.T.); Gesellschaft für Forschungsförderung NÖ (NFB) grant LSC18-022 (J.G.D.); the European Union’s Horizon 2020 research and innovation programme and Marie Skłodowska-Curie Actions Fellowship 665385 (J.L.); and the European Union’s Horizon 2020 research and innovation programme and European Research Council (ERC) grant 101044865 ‘SecretAutism’ (G.N.).Open access funding provided by Institute of Science and Technology (IST Austria).' article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Mojtaba full_name: Tavakoli, Mojtaba id: 3A0A06F4-F248-11E8-B48F-1D18A9856A87 last_name: Tavakoli orcid: 0000-0002-7667-6854 - first_name: Julia full_name: Lyudchik, Julia id: 46E28B80-F248-11E8-B48F-1D18A9856A87 last_name: Lyudchik - first_name: Michał full_name: Januszewski, Michał last_name: Januszewski - first_name: Vitali full_name: Vistunou, Vitali id: 7e146587-8972-11ed-ae7b-d7a32ea86a81 last_name: Vistunou - first_name: Nathalie full_name: Agudelo Duenas, Nathalie id: 40E7F008-F248-11E8-B48F-1D18A9856A87 last_name: Agudelo Duenas - first_name: Jakob full_name: Vorlaufer, Jakob id: 937696FA-C996-11E9-8C7C-CF13E6697425 last_name: Vorlaufer orcid: 0009-0000-7590-3501 - first_name: Christoph M full_name: Sommer, Christoph M id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87 last_name: Sommer orcid: 0000-0003-1216-9105 - first_name: Caroline full_name: Kreuzinger, Caroline id: 382077BA-F248-11E8-B48F-1D18A9856A87 last_name: Kreuzinger - first_name: Bárbara full_name: Oliveira, Bárbara id: 3B03AA1A-F248-11E8-B48F-1D18A9856A87 last_name: Oliveira - first_name: Alban full_name: Cenameri, Alban id: 9ac8f577-2357-11eb-997a-e566c5550886 last_name: Cenameri - first_name: Gaia full_name: Novarino, Gaia id: 3E57A680-F248-11E8-B48F-1D18A9856A87 last_name: Novarino orcid: 0000-0002-7673-7178 - first_name: Viren full_name: Jain, Viren last_name: Jain - first_name: Johann G full_name: Danzl, Johann G id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87 last_name: Danzl orcid: 0000-0001-8559-3973 citation: ama: Tavakoli M, Lyudchik J, Januszewski M, et al. Light-microscopy-based connectomic reconstruction of mammalian brain tissue. Nature. 2025;642:398-410. doi:10.1038/s41586-025-08985-1 apa: Tavakoli, M., Lyudchik, J., Januszewski, M., Vistunou, V., Agudelo Duenas, N., Vorlaufer, J., … Danzl, J. G. (2025). Light-microscopy-based connectomic reconstruction of mammalian brain tissue. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-08985-1 chicago: Tavakoli, Mojtaba, Julia Lyudchik, Michał Januszewski, Vitali Vistunou, Nathalie Agudelo Duenas, Jakob Vorlaufer, Christoph M Sommer, et al. “Light-Microscopy-Based Connectomic Reconstruction of Mammalian Brain Tissue.” Nature. Springer Nature, 2025. https://doi.org/10.1038/s41586-025-08985-1. ieee: M. Tavakoli et al., “Light-microscopy-based connectomic reconstruction of mammalian brain tissue,” Nature, vol. 642. Springer Nature, pp. 398–410, 2025. ista: Tavakoli M, Lyudchik J, Januszewski M, Vistunou V, Agudelo Duenas N, Vorlaufer J, Sommer CM, Kreuzinger C, Oliveira B, Cenameri A, Novarino G, Jain V, Danzl JG. 2025. Light-microscopy-based connectomic reconstruction of mammalian brain tissue. Nature. 642, 398–410. mla: Tavakoli, Mojtaba, et al. “Light-Microscopy-Based Connectomic Reconstruction of Mammalian Brain Tissue.” Nature, vol. 642, Springer Nature, 2025, pp. 398–410, doi:10.1038/s41586-025-08985-1. short: M. Tavakoli, J. Lyudchik, M. Januszewski, V. Vistunou, N. Agudelo Duenas, J. Vorlaufer, C.M. Sommer, C. Kreuzinger, B. Oliveira, A. Cenameri, G. Novarino, V. Jain, J.G. Danzl, Nature 642 (2025) 398–410. corr_author: '1' date_created: 2025-05-18T22:02:51Z date_published: 2025-06-12T00:00:00Z date_updated: 2026-04-28T13:33:34Z day: '12' ddc: - '570' department: - _id: JoDa - _id: GradSch - _id: Bio - _id: GaNo doi: 10.1038/s41586-025-08985-1 ec_funded: 1 external_id: isi: - '001483477000001' pmid: - '40335689' file: - access_level: open_access checksum: ebc99d7108e728f46db0a009292675ef content_type: application/pdf creator: dernst date_created: 2025-07-03T06:55:20Z date_updated: 2025-07-03T06:55:20Z file_id: '19959' file_name: 2025_Nature_Tavakoli.pdf file_size: 133201290 relation: main_file success: 1 file_date_updated: 2025-07-03T06:55:20Z has_accepted_license: '1' intvolume: ' 642' isi: 1 language: - iso: eng month: '06' oa: 1 oa_version: Published Version page: 398-410 pmid: 1 project: - _id: 6285a163-2b32-11ec-9570-8e204ca2dba5 grant_number: '26137' name: Studying Organelle Structure and Function at Nanoscale Resolution with Expansion Microscopy - _id: 2564DBCA-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '665385' name: International IST Doctoral Program - _id: 34ba8964-11ca-11ed-8bc3-e15864e7e9a6 grant_number: '101044865' name: Toward an understanding of the brain interstitial system and the extracellular proteome in health and autism spectrum disorders - _id: 26AA4EF2-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: W1232-B24 name: Molecular Drug Targets publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/piecing-together-the-brain-puzzle/ record: - id: '18677' relation: earlier_version status: public - id: '18697' relation: research_data status: public scopus_import: '1' status: public title: Light-microscopy-based connectomic reconstruction of mammalian brain tissue tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 642 year: '2025' ... --- OA_place: publisher OA_type: hybrid _id: '19278' abstract: - lang: eng text: 'When two insulating, neutral materials are contacted and separated, they exchange electrical charge1. Experiments have long suggested that this ‘contact electrification’ is transitive, with different materials ordering into ‘triboelectric series’ based on the sign of charge acquired2. At the same time, the effect is plagued by unpredictability, preventing consensus on the mechanism and casting doubt on the rhyme and reason that series imply3. Here we expose an unanticipated connection between the unpredictability and order in contact electrification: nominally identical materials initially exchange charge randomly and intransitively, but—over repeated experiments—order into triboelectric series. We find that this evolution is driven by the act of contact itself—samples with more contacts in their history charge negatively to ones with fewer contacts. Capturing this ‘contact bias’ in a minimal model, we recreate both the initial randomness and ultimate order in numerical simulations and use it experimentally to force the appearance of a triboelectric series of our choosing. With a set of surface-sensitive techniques to search for the underlying alterations contact creates, we only find evidence of nanoscale morphological changes, pointing to a mechanism strongly coupled with mechanics. Our results highlight the centrality of contact history in contact electrification and suggest that focusing on the unpredictability that has long plagued the effect may hold the key to understanding it.' acknowledged_ssus: - _id: M-Shop - _id: NanoFab - _id: ScienComp - _id: EM-Fac - _id: LifeSc acknowledgement: This project has received financing from the European Research Council grant agreement no. 949120 under the European Union’s Horizon 2020 research and innovation programme. The Analytical Instrumentation Center of the TU Wien acknowledges support by the FFG project ‘ELSA’ under grant no. 884672. C.M.P. and M.O. acknowledge the state of Lower Austria and the European Regional Development Fund under grant no. WST3-F-542638/004-2021. This research was supported by the Scientific Service Units of the Institute of Science and Technology Austria through resources provided by the Miba Machine Shop, Nanofabrication Facility, Scientific Computing facility, Electron Microscopy Facility and Lab Support Facility. We thank J. Garcia-Suarez and G. Anciaux for the suggestion to look into the roughness power spectral density. We thank I.-M. Strugaru for help with testing the device for Young’s modulus measurements. Open access funding provided by Institute of Science and Technology (IST Austria). article_number: 664-669 article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Juan Carlos A full_name: Sobarzo Ponce, Juan Carlos A id: 4B807D68-AE37-11E9-AC72-31CAE5697425 last_name: Sobarzo Ponce - first_name: Felix full_name: Pertl, Felix id: 6313aec0-15b2-11ec-abd3-ed67d16139af last_name: Pertl orcid: 0000-0003-0463-5794 - first_name: Daniel full_name: Balazs, Daniel id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E last_name: Balazs orcid: 0000-0001-7597-043X - first_name: Tommaso full_name: Costanzo, Tommaso id: D93824F4-D9BA-11E9-BB12-F207E6697425 last_name: Costanzo orcid: 0000-0001-9732-3815 - first_name: Markus full_name: Sauer, Markus last_name: Sauer - first_name: Annette full_name: Foelske, Annette last_name: Foelske - first_name: Markus full_name: Ostermann, Markus last_name: Ostermann - first_name: Christian M. full_name: Pichler, Christian M. last_name: Pichler - first_name: Yongkang full_name: Wang, Yongkang last_name: Wang - first_name: Yuki full_name: Nagata, Yuki last_name: Nagata - first_name: Mischa full_name: Bonn, Mischa last_name: Bonn - first_name: Scott R full_name: Waitukaitis, Scott R id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87 last_name: Waitukaitis orcid: 0000-0002-2299-3176 citation: ama: Sobarzo Ponce JCA, Pertl F, Balazs D, et al. Spontaneous ordering of identical materials into a triboelectric series. Nature. 2025;638(8051). doi:10.1038/s41586-024-08530-6 apa: Sobarzo Ponce, J. C. A., Pertl, F., Balazs, D., Costanzo, T., Sauer, M., Foelske, A., … Waitukaitis, S. R. (2025). Spontaneous ordering of identical materials into a triboelectric series. Nature. Springer Nature. https://doi.org/10.1038/s41586-024-08530-6 chicago: Sobarzo Ponce, Juan Carlos A, Felix Pertl, Daniel Balazs, Tommaso Costanzo, Markus Sauer, Annette Foelske, Markus Ostermann, et al. “Spontaneous Ordering of Identical Materials into a Triboelectric Series.” Nature. Springer Nature, 2025. https://doi.org/10.1038/s41586-024-08530-6. ieee: J. C. A. Sobarzo Ponce et al., “Spontaneous ordering of identical materials into a triboelectric series,” Nature, vol. 638, no. 8051. Springer Nature, 2025. ista: Sobarzo Ponce JCA, Pertl F, Balazs D, Costanzo T, Sauer M, Foelske A, Ostermann M, Pichler CM, Wang Y, Nagata Y, Bonn M, Waitukaitis SR. 2025. Spontaneous ordering of identical materials into a triboelectric series. Nature. 638(8051), 664–669. mla: Sobarzo Ponce, Juan Carlos A., et al. “Spontaneous Ordering of Identical Materials into a Triboelectric Series.” Nature, vol. 638, no. 8051, 664–669, Springer Nature, 2025, doi:10.1038/s41586-024-08530-6. short: J.C.A. Sobarzo Ponce, F. Pertl, D. Balazs, T. Costanzo, M. Sauer, A. Foelske, M. Ostermann, C.M. Pichler, Y. Wang, Y. Nagata, M. Bonn, S.R. Waitukaitis, Nature 638 (2025). corr_author: '1' date_created: 2025-03-02T23:01:52Z date_published: 2025-02-20T00:00:00Z date_updated: 2026-04-28T13:44:56Z day: '20' ddc: - '530' department: - _id: ScWa - _id: LifeSc - _id: EM-Fac doi: 10.1038/s41586-024-08530-6 ec_funded: 1 external_id: isi: - '001428076100015' pmid: - '39972227' file: - access_level: open_access checksum: fecf302274dd3218d3e7dd22f39a6c0c content_type: application/pdf creator: dernst date_created: 2025-03-04T10:05:18Z date_updated: 2025-03-04T10:05:18Z file_id: '19289' file_name: 2025_Nature_Sobarzo.pdf file_size: 3807415 relation: main_file success: 1 file_date_updated: 2025-03-04T10:05:18Z has_accepted_license: '1' intvolume: ' 638' isi: 1 issue: '8051' language: - iso: eng month: '02' oa: 1 oa_version: Published Version pmid: 1 project: - _id: 0aa60e99-070f-11eb-9043-a6de6bdc3afa call_identifier: H2020 grant_number: '949120' name: 'Tribocharge: a multi-scale approach to an enduring problem in physics' publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/an-electrifying-turn-in-an-age-old-quest/ record: - id: '20203' relation: dissertation_contains status: public scopus_import: '1' status: public title: Spontaneous ordering of identical materials into a triboelectric series tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 638 year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '19421' abstract: - lang: eng text: The phytohormone auxin (Aux) is a principal endogenous developmental signal in plants. It mediates transcriptional reprogramming by a well-established canonical signalling mechanism. TIR1/AFB auxin receptors are F-box subunits of an ubiquitin ligase complex; after auxin perception, they associate with Aux/IAA transcriptional repressors and ubiquitinate them for degradation, thus enabling the activation of auxin response factor (ARF) transcription factors1,2,3. Here we revise this paradigm by showing that without TIR1 adenylate cyclase (AC) activity4, auxin-induced degradation of Aux/IAAs is not sufficient to mediate the transcriptional auxin response. Abolishing the TIR1 AC activity does not affect auxin-induced degradation of Aux/IAAs but renders TIR1 non-functional in mediating transcriptional reprogramming and auxin-regulated development, including shoot, root, root hair growth and lateral root formation. Transgenic plants show that local cAMP production in the vicinity of the Aux/IAA–ARF complex by unrelated AC enzymes bypasses the need for auxin perception and is sufficient to induce ARF-mediated transcription. These discoveries revise the canonical model of auxin signalling and establish TIR1/AFB-produced cAMP as a second messenger essential for transcriptional reprograming. acknowledged_ssus: - _id: LifeSc - _id: Bio acknowledgement: We are grateful to J. Callis and H.-Q. Yang for sharing materials and to M. Estelle and S. Kepinski for inspiring discussions. This research was supported by the Laboratory Support Facility, the Plant Facility and the Imaging and Optics Facility of the Institute of Science and Technology Austria. This project has received funding from the European Research Council (101142681 CYNIPS) and Austrian Science Fund (P 37051-B). L.Q. was supported by the National Natural Science Foundation of China (grant no. 32470327). M.Z. was supported by the Interdisciplinary Project Committee of the Institute of Science and Technology Austria, and Y.P. was supported by an EMBO Postdoctoral Fellowship (ALTF 38-2023). Open access funding provided by Institute of Science and Technology (IST Austria). article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Huihuang full_name: Chen, Huihuang id: 83c96512-15b2-11ec-abd3-b7eede36184f last_name: Chen - first_name: Linlin full_name: Qi, Linlin id: 44B04502-A9ED-11E9-B6FC-583AE6697425 last_name: Qi orcid: 0000-0001-5187-8401 - first_name: Minxia full_name: Zou, Minxia id: 5c243f41-03f3-11ec-841c-96faf48a7ef9 last_name: Zou - first_name: Mengting full_name: Lu, Mengting id: a8198a14-1ffe-11ee-8b67-d2bdff9d9178 last_name: Lu - first_name: M full_name: Kwiatkowski, M last_name: Kwiatkowski - first_name: Yuanrong full_name: Pei, Yuanrong id: 98605edc-6ce7-11ee-95f3-cc16b866efcd last_name: Pei - first_name: K full_name: Jaworski, K last_name: Jaworski - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 citation: ama: Chen H, Qi L, Zou M, et al. TIR1-produced cAMP as a second messenger in transcriptional auxin signalling. Nature. 2025;640:1011-1016. doi:10.1038/s41586-025-08669-w apa: Chen, H., Qi, L., Zou, M., Lu, M., Kwiatkowski, M., Pei, Y., … Friml, J. (2025). TIR1-produced cAMP as a second messenger in transcriptional auxin signalling. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-08669-w chicago: Chen, Huihuang, Linlin Qi, Minxia Zou, Mengting Lu, M Kwiatkowski, Yuanrong Pei, K Jaworski, and Jiří Friml. “TIR1-Produced CAMP as a Second Messenger in Transcriptional Auxin Signalling.” Nature. Springer Nature, 2025. https://doi.org/10.1038/s41586-025-08669-w. ieee: H. Chen et al., “TIR1-produced cAMP as a second messenger in transcriptional auxin signalling,” Nature, vol. 640. Springer Nature, pp. 1011–1016, 2025. ista: Chen H, Qi L, Zou M, Lu M, Kwiatkowski M, Pei Y, Jaworski K, Friml J. 2025. TIR1-produced cAMP as a second messenger in transcriptional auxin signalling. Nature. 640, 1011–1016. mla: Chen, Huihuang, et al. “TIR1-Produced CAMP as a Second Messenger in Transcriptional Auxin Signalling.” Nature, vol. 640, Springer Nature, 2025, pp. 1011–16, doi:10.1038/s41586-025-08669-w. short: H. Chen, L. Qi, M. Zou, M. Lu, M. Kwiatkowski, Y. Pei, K. Jaworski, J. Friml, Nature 640 (2025) 1011–1016. corr_author: '1' date_created: 2025-03-19T09:44:39Z date_published: 2025-04-24T00:00:00Z date_updated: 2026-04-28T13:42:45Z day: '24' ddc: - '580' department: - _id: JiFr doi: 10.1038/s41586-025-08669-w external_id: isi: - '001437493900001' pmid: - '40044868' file: - access_level: open_access checksum: f5f18081003e7a1b8e372ecb7da82e7d content_type: application/pdf creator: dernst date_created: 2025-08-05T12:29:35Z date_updated: 2025-08-05T12:29:35Z file_id: '20132' file_name: 2025_Nature_Chen.pdf file_size: 13549245 relation: main_file success: 1 file_date_updated: 2025-08-05T12:29:35Z has_accepted_license: '1' intvolume: ' 640' isi: 1 language: - iso: eng month: '04' oa: 1 oa_version: Published Version page: 1011-1016 pmid: 1 project: - _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6 grant_number: P37051 name: Guanylate cyclase activity of TIR1/AFBs auxin receptors publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/updating-the-textbook/ record: - id: '19478' relation: dissertation_contains status: public status: public title: TIR1-produced cAMP as a second messenger in transcriptional auxin signalling tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 640 year: '2025' ... --- OA_place: publisher OA_type: hybrid _id: '21912' abstract: - lang: eng text: The mammalian fatty acid synthase (FASN) enzyme is a dynamic multienzyme that belongs to the megasynthase family. In mammals, a single gene encodes six catalytically active domains and a flexibly tethered acyl carrier protein (ACP) domain that shuttles intermediates between active sites for fatty acid biosynthesis1. FASN is an essential enzyme in mammalian development through the role that fatty acids have in membrane formation, energy storage, cell signalling and protein modifications. Thus, FASN is a promising target for treatment of a large variety of diseases including cancer, metabolic dysfunction-associated fatty liver disease, and viral and parasite infections2,3. The multi-faceted mechanism of FASN and the dynamic nature of the protein, in particular of the ACP, have made it challenging to understand at the molecular level. Here we report cryo-electron microscopy structures of human FASN in a multitude of conformational states with NADPH and NADP+ plus acetoacetyl-CoA present, including structures with the ACP stalled at the dehydratase (DH) and enoyl-reductase (ER) domains. We show that FASN activity in vitro and de novo lipogenesis in cells is inhibited by mutations at the ACP–DH and ACP–ER interfaces. Together, these studies provide new molecular insights into the dynamic nature of FASN and the ACP shuttling mechanism, with implications for developing improved FASN-targeted therapeutics. article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Kollin full_name: Schultz, Kollin last_name: Schultz - first_name: Pedro full_name: Costa-Pinheiro, Pedro last_name: Costa-Pinheiro - first_name: Lauren full_name: Gardner, Lauren id: f9dedd98-6d15-11f0-88a5-a7b4143fdec5 last_name: Gardner orcid: 0009-0000-5733-1546 - first_name: Laura V. full_name: Pinheiro, Laura V. last_name: Pinheiro - first_name: Julio full_name: Ramirez-Solis, Julio last_name: Ramirez-Solis - first_name: Sarah M. full_name: Gardner, Sarah M. last_name: Gardner - first_name: Kathryn E. full_name: Wellen, Kathryn E. last_name: Wellen - first_name: Ronen full_name: Marmorstein, Ronen last_name: Marmorstein citation: ama: Schultz K, Costa-Pinheiro P, Gardner L, et al. Snapshots of acyl carrier protein shuttling in human fatty acid synthase. Nature. 2025;641(8062):520-528. doi:10.1038/s41586-025-08587-x apa: Schultz, K., Costa-Pinheiro, P., Gardner, L., Pinheiro, L. V., Ramirez-Solis, J., Gardner, S. M., … Marmorstein, R. (2025). Snapshots of acyl carrier protein shuttling in human fatty acid synthase. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-08587-x chicago: Schultz, Kollin, Pedro Costa-Pinheiro, Lauren Gardner, Laura V. Pinheiro, Julio Ramirez-Solis, Sarah M. Gardner, Kathryn E. Wellen, and Ronen Marmorstein. “Snapshots of Acyl Carrier Protein Shuttling in Human Fatty Acid Synthase.” Nature. Springer Nature, 2025. https://doi.org/10.1038/s41586-025-08587-x. ieee: K. Schultz et al., “Snapshots of acyl carrier protein shuttling in human fatty acid synthase,” Nature, vol. 641, no. 8062. Springer Nature, pp. 520–528, 2025. ista: Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R. 2025. Snapshots of acyl carrier protein shuttling in human fatty acid synthase. Nature. 641(8062), 520–528. mla: Schultz, Kollin, et al. “Snapshots of Acyl Carrier Protein Shuttling in Human Fatty Acid Synthase.” Nature, vol. 641, no. 8062, Springer Nature, 2025, pp. 520–28, doi:10.1038/s41586-025-08587-x. short: K. Schultz, P. Costa-Pinheiro, L. Gardner, L.V. Pinheiro, J. Ramirez-Solis, S.M. Gardner, K.E. Wellen, R. Marmorstein, Nature 641 (2025) 520–528. date_created: 2026-05-24T08:25:19Z date_published: 2025-05-08T00:00:00Z date_updated: 2026-06-02T14:57:52Z day: '08' ddc: - '572' doi: 10.1038/s41586-025-08587-x extern: '1' external_id: pmid: - '39979457 ' has_accepted_license: '1' intvolume: ' 641' issue: '8062' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1038/s41586-025-08587-x month: '05' oa: 1 oa_version: Published Version page: 520-528 pmid: 1 publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' status: public title: Snapshots of acyl carrier protein shuttling in human fatty acid synthase tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 641 year: '2025' ... --- OA_type: closed access _id: '18616' abstract: - lang: eng text: By patterning an ultrathin layered structure with tiny wells, physicists have created and imaged peculiar states known as quantum scars — revealing behaviour that could be used to boost the performance of electronic devices. article_processing_charge: No article_type: letter_note author: - first_name: Dmitry full_name: Abanin, Dmitry last_name: Abanin - first_name: Maksym full_name: Serbyn, Maksym id: 47809E7E-F248-11E8-B48F-1D18A9856A87 last_name: Serbyn orcid: 0000-0002-2399-5827 citation: ama: Abanin D, Serbyn M. Quantum scars make their mark in graphene. Nature. 2024;635(8040):825-826. doi:10.1038/d41586-024-03649-y apa: Abanin, D., & Serbyn, M. (2024). Quantum scars make their mark in graphene. Nature. Springer Nature. https://doi.org/10.1038/d41586-024-03649-y chicago: Abanin, Dmitry, and Maksym Serbyn. “Quantum Scars Make Their Mark in Graphene.” Nature. Springer Nature, 2024. https://doi.org/10.1038/d41586-024-03649-y. ieee: D. Abanin and M. Serbyn, “Quantum scars make their mark in graphene,” Nature, vol. 635, no. 8040. Springer Nature, pp. 825–826, 2024. ista: Abanin D, Serbyn M. 2024. Quantum scars make their mark in graphene. Nature. 635(8040), 825–826. mla: Abanin, Dmitry, and Maksym Serbyn. “Quantum Scars Make Their Mark in Graphene.” Nature, vol. 635, no. 8040, Springer Nature, 2024, pp. 825–26, doi:10.1038/d41586-024-03649-y. short: D. Abanin, M. Serbyn, Nature 635 (2024) 825–826. date_created: 2024-12-03T18:08:16Z date_published: 2024-11-27T00:00:00Z date_updated: 2025-09-08T14:57:35Z day: '27' department: - _id: MaSe doi: 10.1038/d41586-024-03649-y external_id: isi: - '001367935000029' pmid: - '39604614' intvolume: ' 635' isi: 1 issue: '8040' language: - iso: eng month: '11' oa_version: None page: 825-826 pmid: 1 publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: Quantum scars make their mark in graphene type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 635 year: '2024' ... --- _id: '17284' abstract: - lang: eng text: Platelet homeostasis is essential for vascular integrity and immune defence1,2. Although the process of platelet formation by fragmenting megakaryocytes (MKs; thrombopoiesis) has been extensively studied, the cellular and molecular mechanisms required to constantly replenish the pool of MKs by their progenitor cells (megakaryopoiesis) remains unclear3,4. Here we use intravital imaging to track the cellular dynamics of megakaryopoiesis over days. We identify plasmacytoid dendritic cells (pDCs) as homeostatic sensors that monitor the bone marrow for apoptotic MKs and deliver IFNα to the MK niche triggering local on-demand proliferation and maturation of MK progenitors. This pDC-dependent feedback loop is crucial for MK and platelet homeostasis at steady state and under stress. pDCs are best known for their ability to function as vigilant detectors of viral infection5. We show that virus-induced activation of pDCs interferes with their function as homeostatic sensors of megakaryopoiesis. Consequently, activation of pDCs by SARS-CoV-2 leads to excessive megakaryopoiesis. Together, we identify a pDC-dependent homeostatic circuit that involves innate immune sensing and demand-adapted release of inflammatory mediators to maintain homeostasis of the megakaryocytic lineage. acknowledgement: 'We thank S. Helmer, N. Blount, E. Raatz and Z. Sisic for technical assistance. This work was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) SFB 1123 (S.M. project B06); SFB 914 (S.M. projects B02 and Z01, H.I.-A. project Z01, S.S. project A06, K.S. project B02, C. Schulz project A10, B.W. project A02, C. Scheiermann project B09); SFB 1054 (T.B. project B03); FOR2033 (F.G., R.A.J.O., S.M.); Individual research grant project ID: 514478744 (F.G.); Heisenberg Programme project ID: 514477451 (F.G.); the DZHK (German Center for Cardiovascular Research) (MHA 1.4VD (S.M.), Postdoc Start-up Grant, 81×3600213 (F.G.)); and LMUexcellence NFF (F.G.). W.F. received funding from China Scholarship Council (CSC, no. 201306270012). P.B. is supported by the German Research Foundation (DFG, project IDs 322900939, 432698239 and 445703531), European Research Council (ERC Consolidator grant no. 101001791) and the Federal Ministry of Education and Research (BMBF, STOP-FSGS-01GM2202C and NATON within the framework of the Network of University Medicine, no. 01KX2121). S.v.S. is supported by the START-Program of the Faculty of Medicine of the RWTH Aachen University (AZ 125/17). A.D. and S.E. are supported by the German Research Foundation (SFB TRR 267); S.E. by the BMBF in the framework of the Cluster4future program (CNATM—Cluster for Nucleic Acid Therapeutics Munich). This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 833440 to S.M.). F.G. received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 747687. The project is funded by the European Union (ERC, MEKanics, 101078110). Views and opinions expressed are those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.' article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Florian R full_name: Gärtner, Florian R id: 397A88EE-F248-11E8-B48F-1D18A9856A87 last_name: Gärtner orcid: 0000-0001-6120-3723 - first_name: Hellen full_name: Ishikawa-Ankerhold, Hellen last_name: Ishikawa-Ankerhold - first_name: Susanne full_name: Stutte, Susanne last_name: Stutte - first_name: Wenwen full_name: Fu, Wenwen last_name: Fu - first_name: Jutta full_name: Weitz, Jutta last_name: Weitz - first_name: Anne full_name: Dueck, Anne last_name: Dueck - first_name: Bhavishya full_name: Nelakuditi, Bhavishya last_name: Nelakuditi - first_name: Valeria full_name: Fumagalli, Valeria last_name: Fumagalli - first_name: Dominic full_name: Van Den Heuvel, Dominic last_name: Van Den Heuvel - first_name: Larissa full_name: Belz, Larissa last_name: Belz - first_name: Gulnoza full_name: Sobirova, Gulnoza last_name: Sobirova - first_name: Zhe full_name: Zhang, Zhe last_name: Zhang - first_name: Anna full_name: Titova, Anna last_name: Titova - first_name: Alejandro Martinez full_name: Navarro, Alejandro Martinez last_name: Navarro - first_name: Kami full_name: Pekayvaz, Kami last_name: Pekayvaz - first_name: Michael full_name: Lorenz, Michael last_name: Lorenz - first_name: Louisa full_name: Von Baumgarten, Louisa last_name: Von Baumgarten - first_name: Jan full_name: Kranich, Jan last_name: Kranich - first_name: Tobias full_name: Straub, Tobias last_name: Straub - first_name: Bastian full_name: Popper, Bastian last_name: Popper - first_name: Vanessa full_name: Zheden, Vanessa id: 39C5A68A-F248-11E8-B48F-1D18A9856A87 last_name: Zheden orcid: 0000-0002-9438-4783 - first_name: Walter full_name: Kaufmann, Walter id: 3F99E422-F248-11E8-B48F-1D18A9856A87 last_name: Kaufmann orcid: 0000-0001-9735-5315 - first_name: Chenglong full_name: Guo, Chenglong last_name: Guo - first_name: Guido full_name: Piontek, Guido last_name: Piontek - first_name: Saskia full_name: Von Stillfried, Saskia last_name: Von Stillfried - first_name: Peter full_name: Boor, Peter last_name: Boor - first_name: Marco full_name: Colonna, Marco last_name: Colonna - first_name: Sebastian full_name: Clauß, Sebastian last_name: Clauß - first_name: Christian full_name: Schulz, Christian last_name: Schulz - first_name: Thomas full_name: Brocker, Thomas last_name: Brocker - first_name: Barbara full_name: Walzog, Barbara last_name: Walzog - first_name: Christoph full_name: Scheiermann, Christoph last_name: Scheiermann - first_name: William C. full_name: Aird, William C. last_name: Aird - first_name: Claus full_name: Nerlov, Claus last_name: Nerlov - first_name: Konstantin full_name: Stark, Konstantin last_name: Stark - first_name: Tobias full_name: Petzold, Tobias last_name: Petzold - first_name: Stefan full_name: Engelhardt, Stefan last_name: Engelhardt - first_name: Michael K full_name: Sixt, Michael K id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87 last_name: Sixt orcid: 0000-0002-6620-9179 - first_name: Robert full_name: Hauschild, Robert id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87 last_name: Hauschild orcid: 0000-0001-9843-3522 - first_name: Martina full_name: Rudelius, Martina last_name: Rudelius - first_name: Robert A.J. full_name: Oostendorp, Robert A.J. last_name: Oostendorp - first_name: Matteo full_name: Iannacone, Matteo last_name: Iannacone - first_name: Matthias full_name: Heinig, Matthias last_name: Heinig - first_name: Steffen full_name: Massberg, Steffen last_name: Massberg citation: ama: Gärtner FR, Ishikawa-Ankerhold H, Stutte S, et al. Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis. Nature. 2024;631:645-653. doi:10.1038/s41586-024-07671-y apa: Gärtner, F. R., Ishikawa-Ankerhold, H., Stutte, S., Fu, W., Weitz, J., Dueck, A., … Massberg, S. (2024). Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis. Nature. Springer Nature. https://doi.org/10.1038/s41586-024-07671-y chicago: Gärtner, Florian R, Hellen Ishikawa-Ankerhold, Susanne Stutte, Wenwen Fu, Jutta Weitz, Anne Dueck, Bhavishya Nelakuditi, et al. “Plasmacytoid Dendritic Cells Control Homeostasis of Megakaryopoiesis.” Nature. Springer Nature, 2024. https://doi.org/10.1038/s41586-024-07671-y. ieee: F. R. Gärtner et al., “Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis,” Nature, vol. 631. Springer Nature, pp. 645–653, 2024. ista: Gärtner FR, Ishikawa-Ankerhold H, Stutte S, Fu W, Weitz J, Dueck A, Nelakuditi B, Fumagalli V, Van Den Heuvel D, Belz L, Sobirova G, Zhang Z, Titova A, Navarro AM, Pekayvaz K, Lorenz M, Von Baumgarten L, Kranich J, Straub T, Popper B, Zheden V, Kaufmann W, Guo C, Piontek G, Von Stillfried S, Boor P, Colonna M, Clauß S, Schulz C, Brocker T, Walzog B, Scheiermann C, Aird WC, Nerlov C, Stark K, Petzold T, Engelhardt S, Sixt MK, Hauschild R, Rudelius M, Oostendorp RAJ, Iannacone M, Heinig M, Massberg S. 2024. Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis. Nature. 631, 645–653. mla: Gärtner, Florian R., et al. “Plasmacytoid Dendritic Cells Control Homeostasis of Megakaryopoiesis.” Nature, vol. 631, Springer Nature, 2024, pp. 645–53, doi:10.1038/s41586-024-07671-y. short: F.R. Gärtner, H. Ishikawa-Ankerhold, S. Stutte, W. Fu, J. Weitz, A. Dueck, B. Nelakuditi, V. Fumagalli, D. Van Den Heuvel, L. Belz, G. Sobirova, Z. Zhang, A. Titova, A.M. Navarro, K. Pekayvaz, M. Lorenz, L. Von Baumgarten, J. Kranich, T. Straub, B. Popper, V. Zheden, W. Kaufmann, C. Guo, G. Piontek, S. Von Stillfried, P. Boor, M. Colonna, S. Clauß, C. Schulz, T. Brocker, B. Walzog, C. Scheiermann, W.C. Aird, C. Nerlov, K. Stark, T. Petzold, S. Engelhardt, M.K. Sixt, R. Hauschild, M. Rudelius, R.A.J. Oostendorp, M. Iannacone, M. Heinig, S. Massberg, Nature 631 (2024) 645–653. corr_author: '1' date_created: 2024-07-21T22:01:02Z date_published: 2024-07-18T00:00:00Z date_updated: 2025-09-08T08:14:25Z day: '18' ddc: - '570' department: - _id: EM-Fac - _id: MiSi - _id: Bio doi: 10.1038/s41586-024-07671-y ec_funded: 1 external_id: isi: - '001281636500020' pmid: - '38987596' file: - access_level: open_access checksum: aa004afc72d2489f0fb0fcbc9919fbbd content_type: application/pdf creator: dernst date_created: 2024-07-22T06:16:11Z date_updated: 2024-07-22T06:16:11Z file_id: '17286' file_name: 2024_Nature_Gaertner.pdf file_size: 15704819 relation: main_file success: 1 file_date_updated: 2024-07-22T06:16:11Z has_accepted_license: '1' intvolume: ' 631' isi: 1 language: - iso: eng month: '07' oa: 1 oa_version: Published Version page: 645-653 pmid: 1 project: - _id: 260AA4E2-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '747687' name: Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: link: - relation: software url: https://github.com/heiniglab/gaertner_megakaryocytes scopus_import: '1' status: public title: Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 631 year: '2024' ... --- OA_place: repository OA_type: green _id: '17442' abstract: - lang: eng text: "Although eukaryotic Argonautes have a pivotal role in post-transcriptional gene regulation through nucleic acid cleavage, some short prokaryotic Argonaute variants (pAgos) rely on auxiliary nuclease factors for efficient foreign DNA degradation1. Here we reveal the activation pathway of the DNA defence module DdmDE system, which rapidly eliminates small, multicopy plasmids from the Vibrio cholerae seventh pandemic strain (7PET)2. Through a combination of cryo-electron microscopy, biochemistry and in vivo plasmid clearance assays, we demonstrate that DdmE is a catalytically inactive, DNA-guided, DNA-targeting pAgo with a distinctive insertion domain. We observe that the helicase-nuclease DdmD transitions from an autoinhibited, dimeric complex to a monomeric state upon loading of single-stranded DNA targets. Furthermore, the complete structure of the DdmDE–guide–target handover complex provides a comprehensive view into how DNA recognition triggers processive plasmid destruction. Our work establishes a mechanistic foundation for how pAgos utilize ancillary factors to achieve plasmid clearance, and provides insights into anti-plasmid immunity in bacteria.\r\n\r\n" acknowledgement: We thank K. Kiernan, G. Hibshman and I. Strohkendl for insightful discussions and comments on the manuscript, and R. Lin for assistance with the ATPase assay. Data were collected at the Sauer Structural Biology Laboratory at the University of Texas at Austin. This work was supported in part by the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH) R35GM138348 (to D.W.T.) and Welch Foundation research grant F-1938 (to D.W.T.). article_processing_charge: No article_type: original author: - first_name: Jack Peter Kelly full_name: Bravo, Jack Peter Kelly id: 96aecfa5-8931-11ee-af30-aa6a5d6eee0e last_name: Bravo orcid: 0000-0003-0456-0753 - first_name: Delisa A. full_name: Ramos, Delisa A. last_name: Ramos - first_name: Rodrigo full_name: Fregoso Ocampo, Rodrigo last_name: Fregoso Ocampo - first_name: Caiden full_name: Ingram, Caiden last_name: Ingram - first_name: David W. full_name: Taylor, David W. last_name: Taylor citation: ama: Bravo JPK, Ramos DA, Fregoso Ocampo R, Ingram C, Taylor DW. Plasmid targeting and destruction by the DdmDE bacterial defence system. Nature. 2024;630(8018):961-967. doi:10.1038/s41586-024-07515-9 apa: Bravo, J. P. K., Ramos, D. A., Fregoso Ocampo, R., Ingram, C., & Taylor, D. W. (2024). Plasmid targeting and destruction by the DdmDE bacterial defence system. Nature. Springer Nature. https://doi.org/10.1038/s41586-024-07515-9 chicago: Bravo, Jack Peter Kelly, Delisa A. Ramos, Rodrigo Fregoso Ocampo, Caiden Ingram, and David W. Taylor. “Plasmid Targeting and Destruction by the DdmDE Bacterial Defence System.” Nature. Springer Nature, 2024. https://doi.org/10.1038/s41586-024-07515-9. ieee: J. P. K. Bravo, D. A. Ramos, R. Fregoso Ocampo, C. Ingram, and D. W. Taylor, “Plasmid targeting and destruction by the DdmDE bacterial defence system,” Nature, vol. 630, no. 8018. Springer Nature, pp. 961–967, 2024. ista: Bravo JPK, Ramos DA, Fregoso Ocampo R, Ingram C, Taylor DW. 2024. Plasmid targeting and destruction by the DdmDE bacterial defence system. Nature. 630(8018), 961–967. mla: Bravo, Jack Peter Kelly, et al. “Plasmid Targeting and Destruction by the DdmDE Bacterial Defence System.” Nature, vol. 630, no. 8018, Springer Nature, 2024, pp. 961–67, doi:10.1038/s41586-024-07515-9. short: J.P.K. Bravo, D.A. Ramos, R. Fregoso Ocampo, C. Ingram, D.W. Taylor, Nature 630 (2024) 961–967. corr_author: '1' date_created: 2024-08-19T09:41:18Z date_published: 2024-06-27T00:00:00Z date_updated: 2025-06-24T12:47:21Z day: '27' department: - _id: JaBr doi: 10.1038/s41586-024-07515-9 external_id: pmid: - '38740055' intvolume: ' 630' issue: '8018' language: - iso: eng main_file_link: - open_access: '1' url: https://pmc.ncbi.nlm.nih.gov/articles/PMC11649018/ month: '06' oa: 1 oa_version: Submitted Version page: 961-967 pmid: 1 publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: Plasmid targeting and destruction by the DdmDE bacterial defence system type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 630 year: '2024' ... --- _id: '17463' abstract: - lang: eng text: Allosteric modulation of protein function, wherein the binding of an effector to a protein triggers conformational changes at distant functional sites, plays a central part in the control of metabolism and cell signalling1,2,3. There has been considerable interest in designing allosteric systems, both to gain insight into the mechanisms underlying such ‘action at a distance’ modulation and to create synthetic proteins whose functions can be regulated by effectors4,5,6,7. However, emulating the subtle conformational changes distributed across many residues, characteristic of natural allosteric proteins, is a significant challenge8,9. Here, inspired by the classic Monod–Wyman–Changeux model of cooperativity10, we investigate the de novo design of allostery through rigid-body coupling of peptide-switchable hinge modules11 to protein interfaces12 that direct the formation of alternative oligomeric states. We find that this approach can be used to generate a wide variety of allosterically switchable systems, including cyclic rings that incorporate or eject subunits in response to peptide binding and dihedral cages that undergo effector-induced disassembly. Size-exclusion chromatography, mass photometry13 and electron microscopy reveal that these designed allosteric protein assemblies closely resemble the design models in both the presence and absence of peptide effectors and can have ligand-binding cooperativity comparable to classic natural systems such as haemoglobin14. Our results indicate that allostery can arise from global coupling of the energetics of protein substructures without optimized side-chain–side-chain allosteric communication pathways and provide a roadmap for generating allosterically triggerable delivery systems, protein nanomachines and cellular feedback control circuitry. acknowledgement: We thank D. D. Sahtoe, R. D. Kiber, Y. Hsia, N. Bethel and A. Favor for helpful discussions and K. VanWormer and L. Goldschmidt for technical support. We also thank X. Li and M. Lamb for mass spectrometry support. This work was supported by the Washington Research Foundation Postdoctoral Fellowship (grant no. GR027504, A. Pillai), a National Science Foundation Graduate Research Fellowship (grant no. DGE-2140004, A.I.), a Human Frontier Science Program Long Term Fellowship (grant no. LT000880/2019, F.P.), the Audacious Project at the Institute for Protein Design (A.B., A. Pillai, A. Philomin, A.I. and D.B.), a National Energy Research Scientific Computing Centre award (grant no. BER-ERCAP0022018), the Howard Hughes Medical Institute (D.B.), the Open Philanthropy Project Improving Protein Design Fund (P.J.Y.L., C.D. and D.B.) a gift from Microsoft (D.B.) and a grant from DARPA supporting the Harnessing Enzymatic Activity for Lifesaving Remedies programme (grant no. HR001120S0052, contract no. HR0011-21-2-0012, D.B.). article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Arvind full_name: Pillai, Arvind last_name: Pillai - first_name: Abbas full_name: Idris, Abbas last_name: Idris - first_name: Annika full_name: Philomin, Annika last_name: Philomin - first_name: Connor full_name: Weidle, Connor last_name: Weidle - first_name: Rebecca full_name: Skotheim, Rebecca last_name: Skotheim - first_name: Philip J.Y. full_name: Leung, Philip J.Y. last_name: Leung - first_name: Adam full_name: Broerman, Adam last_name: Broerman - first_name: Cullen full_name: Demakis, Cullen last_name: Demakis - first_name: Andrew J. full_name: Borst, Andrew J. last_name: Borst - first_name: Florian M full_name: Praetorius, Florian M id: dfec9381-4341-11ee-8fd8-faa02bba7d62 last_name: Praetorius - first_name: David full_name: Baker, David last_name: Baker citation: ama: Pillai A, Idris A, Philomin A, et al. De novo design of allosterically switchable protein assemblies. Nature. 2024;632:911–920. doi:10.1038/s41586-024-07813-2 apa: Pillai, A., Idris, A., Philomin, A., Weidle, C., Skotheim, R., Leung, P. J. Y., … Baker, D. (2024). De novo design of allosterically switchable protein assemblies. Nature. Springer Nature. https://doi.org/10.1038/s41586-024-07813-2 chicago: Pillai, Arvind, Abbas Idris, Annika Philomin, Connor Weidle, Rebecca Skotheim, Philip J.Y. Leung, Adam Broerman, et al. “De Novo Design of Allosterically Switchable Protein Assemblies.” Nature. Springer Nature, 2024. https://doi.org/10.1038/s41586-024-07813-2. ieee: A. Pillai et al., “De novo design of allosterically switchable protein assemblies,” Nature, vol. 632. Springer Nature, pp. 911–920, 2024. ista: Pillai A, Idris A, Philomin A, Weidle C, Skotheim R, Leung PJY, Broerman A, Demakis C, Borst AJ, Praetorius FM, Baker D. 2024. De novo design of allosterically switchable protein assemblies. Nature. 632, 911–920. mla: Pillai, Arvind, et al. “De Novo Design of Allosterically Switchable Protein Assemblies.” Nature, vol. 632, Springer Nature, 2024, pp. 911–920, doi:10.1038/s41586-024-07813-2. short: A. Pillai, A. Idris, A. Philomin, C. Weidle, R. Skotheim, P.J.Y. Leung, A. Broerman, C. Demakis, A.J. Borst, F.M. Praetorius, D. Baker, Nature 632 (2024) 911–920. corr_author: '1' date_created: 2024-08-25T22:01:08Z date_published: 2024-08-22T00:00:00Z date_updated: 2025-09-08T09:00:16Z day: '22' ddc: - '570' department: - _id: FlPr doi: 10.1038/s41586-024-07813-2 external_id: isi: - '001300534300019' pmid: - '39143214' file: - access_level: open_access checksum: 39127601621a360ec0edc538627eb211 content_type: application/pdf creator: dernst date_created: 2024-09-09T12:01:14Z date_updated: 2024-09-09T12:01:14Z file_id: '18005' file_name: 2024_Nature_Pillai.pdf file_size: 16572040 relation: main_file success: 1 file_date_updated: 2024-09-09T12:01:14Z has_accepted_license: '1' intvolume: ' 632' isi: 1 language: - iso: eng month: '08' oa: 1 oa_version: Published Version page: '911–920 ' pmid: 1 publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: De novo design of allosterically switchable protein assemblies tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 632 year: '2024' ... --- _id: '14341' abstract: - lang: eng text: Flows through pipes and channels are, in practice, almost always turbulent, and the multiscale eddying motion is responsible for a major part of the encountered friction losses and pumping costs1. Conversely, for pulsatile flows, in particular for aortic blood flow, turbulence levels remain low despite relatively large peak velocities. For aortic blood flow, high turbulence levels are intolerable as they would damage the shear-sensitive endothelial cell layer2,3,4,5. Here we show that turbulence in ordinary pipe flow is diminished if the flow is driven in a pulsatile mode that incorporates all the key features of the cardiac waveform. At Reynolds numbers comparable to those of aortic blood flow, turbulence is largely inhibited, whereas at much higher speeds, the turbulent drag is reduced by more than 25%. This specific operation mode is more efficient when compared with steady driving, which is the present situation for virtually all fluid transport processes ranging from heating circuits to water, gas and oil pipelines. acknowledged_ssus: - _id: M-Shop - _id: ScienComp acknowledgement: We acknowledge the assistance of the Miba machine shop and the team of the ISTA-HPC cluster. We thank M. Quadrio for the discussions. The work was supported by the Simons Foundation (grant no. 662960) and by the Austrian Science Fund (grant no. I4188-N30), within Deutsche Forschungsgemeinschaft research unit FOR 2688. article_processing_charge: No article_type: original author: - first_name: Davide full_name: Scarselli, Davide id: 40315C30-F248-11E8-B48F-1D18A9856A87 last_name: Scarselli orcid: 0000-0001-5227-4271 - first_name: Jose M full_name: Lopez Alonso, Jose M id: 40770848-F248-11E8-B48F-1D18A9856A87 last_name: Lopez Alonso orcid: 0000-0002-0384-2022 - first_name: Atul full_name: Varshney, Atul id: 2A2006B2-F248-11E8-B48F-1D18A9856A87 last_name: Varshney orcid: 0000-0002-3072-5999 - first_name: Björn full_name: Hof, Björn id: 3A374330-F248-11E8-B48F-1D18A9856A87 last_name: Hof orcid: 0000-0003-2057-2754 citation: ama: Scarselli D, Lopez Alonso JM, Varshney A, Hof B. Turbulence suppression by cardiac-cycle-inspired driving of pipe flow. Nature. 2023;621(7977):71-74. doi:10.1038/s41586-023-06399-5 apa: Scarselli, D., Lopez Alonso, J. M., Varshney, A., & Hof, B. (2023). Turbulence suppression by cardiac-cycle-inspired driving of pipe flow. Nature. Springer Nature. https://doi.org/10.1038/s41586-023-06399-5 chicago: Scarselli, Davide, Jose M Lopez Alonso, Atul Varshney, and Björn Hof. “Turbulence Suppression by Cardiac-Cycle-Inspired Driving of Pipe Flow.” Nature. Springer Nature, 2023. https://doi.org/10.1038/s41586-023-06399-5. ieee: D. Scarselli, J. M. Lopez Alonso, A. Varshney, and B. Hof, “Turbulence suppression by cardiac-cycle-inspired driving of pipe flow,” Nature, vol. 621, no. 7977. Springer Nature, pp. 71–74, 2023. ista: Scarselli D, Lopez Alonso JM, Varshney A, Hof B. 2023. Turbulence suppression by cardiac-cycle-inspired driving of pipe flow. Nature. 621(7977), 71–74. mla: Scarselli, Davide, et al. “Turbulence Suppression by Cardiac-Cycle-Inspired Driving of Pipe Flow.” Nature, vol. 621, no. 7977, Springer Nature, 2023, pp. 71–74, doi:10.1038/s41586-023-06399-5. short: D. Scarselli, J.M. Lopez Alonso, A. Varshney, B. Hof, Nature 621 (2023) 71–74. corr_author: '1' date_created: 2023-09-17T22:01:09Z date_published: 2023-09-07T00:00:00Z date_updated: 2025-09-09T12:59:04Z day: '07' ddc: - '530' department: - _id: BjHo doi: 10.1038/s41586-023-06399-5 external_id: isi: - '001168947700009' pmid: - '37673988' file: - access_level: open_access checksum: 9c9f172ba0a9a301d76fff4229812464 content_type: application/pdf creator: dernst date_created: 2024-06-04T09:24:34Z date_updated: 2024-06-04T09:24:34Z file_id: '17118' file_name: 2023_submittedversion.pdf file_size: 3247252 relation: main_file success: 1 file_date_updated: 2024-06-04T09:24:34Z has_accepted_license: '1' intvolume: ' 621' isi: 1 issue: '7977' language: - iso: eng month: '09' oa: 1 oa_version: Submitted Version page: 71-74 pmid: 1 project: - _id: 238598C6-32DE-11EA-91FC-C7463DDC885E grant_number: '662960' name: Revisiting the Turbulence Problem Using Statistical Mechanics - _id: 238B8092-32DE-11EA-91FC-C7463DDC885E call_identifier: FWF grant_number: I04188 name: Instabilities in pulsating pipe flow in complex fluids publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://www.ista.ac.at/en/news/pumping-like-the-heart/ scopus_import: '1' status: public title: Turbulence suppression by cardiac-cycle-inspired driving of pipe flow type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 621 year: '2023' ... --- _id: '14610' abstract: - lang: eng text: Endomembrane damage represents a form of stress that is detrimental for eukaryotic cells1,2. To cope with this threat, cells possess mechanisms that repair the damage and restore cellular homeostasis3–7. Endomembrane damage also results in organelle instability and the mechanisms by which cells stabilize damaged endomembranes to enable membrane repair remains unknown. Here, by combining in vitro and in cellulo studies with computational modelling we uncover a biological function for stress granules whereby these biomolecular condensates form rapidly at endomembrane damage sites and act as a plug that stabilizes the ruptured membrane. Functionally, we demonstrate that stress granule formation and membrane stabilization enable efficient repair of damaged endolysosomes, through both ESCRT (endosomal sorting complex required for transport)-dependent and independent mechanisms. We also show that blocking stress granule formation in human macrophages creates a permissive environment for Mycobacterium tuberculosis, a human pathogen that exploits endomembrane damage to survive within the host. acknowledgement: "We thank the Human Embryonic Stem Cell Unit, Advanced Light Microscopy and High-throughput Screening facilities at the Crick for their support in various aspects of the work. We thank the laboratory of P. Anderson for providing the G3BP-DKO U2OS cells. The authors thank N. Chen for providing the purified glycinin protein; Z. Zhao for providing the microfluidic chip wafers; and M. Amaral and F. Frey for helpful discussions and valuable input regarding analysis methods. This work was supported by the Francis Crick Institute (to M.G.G.), which receives its core funding from Cancer Research UK (FC001092), the UK Medical Research Council (FC001092) and the Wellcome Trust (FC001092). This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 772022 to M.G.G.). C.B. has received funding from the European Respiratory Society and the European Union’s H2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 713406. A.M. acknowledges support from Alexander von Humboldt Foundation and C.V.-C. acknowledges funding by the Royal Society and the European Research Council under the European Union’s Horizon 2020 Research and Innovation Programme (grant no. 802960 to A.S.). All simulations were carried out on the high-performance computing cluster at the Institute of Science and Technology Austria. For the purpose of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.\r\nOpen Access funding provided by The Francis Crick Institute." article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Claudio full_name: Bussi, Claudio last_name: Bussi - first_name: Agustín full_name: Mangiarotti, Agustín last_name: Mangiarotti - first_name: Christian Eduardo full_name: Vanhille-Campos, Christian Eduardo id: 3adeca52-9313-11ed-b1ac-c170b2505714 last_name: Vanhille-Campos - first_name: Beren full_name: Aylan, Beren last_name: Aylan - first_name: Enrica full_name: Pellegrino, Enrica last_name: Pellegrino - first_name: Natalia full_name: Athanasiadi, Natalia last_name: Athanasiadi - first_name: Antony full_name: Fearns, Antony last_name: Fearns - first_name: Angela full_name: Rodgers, Angela last_name: Rodgers - first_name: Titus M. full_name: Franzmann, Titus M. last_name: Franzmann - first_name: Anđela full_name: Šarić, Anđela id: bf63d406-f056-11eb-b41d-f263a6566d8b last_name: Šarić orcid: 0000-0002-7854-2139 - first_name: Rumiana full_name: Dimova, Rumiana last_name: Dimova - first_name: Maximiliano G. full_name: Gutierrez, Maximiliano G. last_name: Gutierrez citation: ama: Bussi C, Mangiarotti A, Vanhille-Campos CE, et al. Stress granules plug and stabilize damaged endolysosomal membranes. Nature. 2023;623:1062-1069. doi:10.1038/s41586-023-06726-w apa: Bussi, C., Mangiarotti, A., Vanhille-Campos, C. E., Aylan, B., Pellegrino, E., Athanasiadi, N., … Gutierrez, M. G. (2023). Stress granules plug and stabilize damaged endolysosomal membranes. Nature. Springer Nature. https://doi.org/10.1038/s41586-023-06726-w chicago: Bussi, Claudio, Agustín Mangiarotti, Christian Eduardo Vanhille-Campos, Beren Aylan, Enrica Pellegrino, Natalia Athanasiadi, Antony Fearns, et al. “Stress Granules Plug and Stabilize Damaged Endolysosomal Membranes.” Nature. Springer Nature, 2023. https://doi.org/10.1038/s41586-023-06726-w. ieee: C. Bussi et al., “Stress granules plug and stabilize damaged endolysosomal membranes,” Nature, vol. 623. Springer Nature, pp. 1062–1069, 2023. ista: Bussi C, Mangiarotti A, Vanhille-Campos CE, Aylan B, Pellegrino E, Athanasiadi N, Fearns A, Rodgers A, Franzmann TM, Šarić A, Dimova R, Gutierrez MG. 2023. Stress granules plug and stabilize damaged endolysosomal membranes. Nature. 623, 1062–1069. mla: Bussi, Claudio, et al. “Stress Granules Plug and Stabilize Damaged Endolysosomal Membranes.” Nature, vol. 623, Springer Nature, 2023, pp. 1062–69, doi:10.1038/s41586-023-06726-w. short: C. Bussi, A. Mangiarotti, C.E. Vanhille-Campos, B. Aylan, E. Pellegrino, N. Athanasiadi, A. Fearns, A. Rodgers, T.M. Franzmann, A. Šarić, R. Dimova, M.G. Gutierrez, Nature 623 (2023) 1062–1069. date_created: 2023-11-27T07:56:37Z date_published: 2023-11-30T00:00:00Z date_updated: 2025-09-09T13:30:34Z day: '30' ddc: - '570' department: - _id: AnSa doi: 10.1038/s41586-023-06726-w external_id: isi: - '001105882300018' pmid: - '37968398' file: - access_level: open_access checksum: b939a19e4c228fbf3beca298ac2ac014 content_type: application/pdf creator: dernst date_created: 2024-07-16T07:41:39Z date_updated: 2024-07-16T07:41:39Z file_id: '17248' file_name: 2023_Nature_Bussi.pdf file_size: 17047711 relation: main_file success: 1 file_date_updated: 2024-07-16T07:41:39Z has_accepted_license: '1' intvolume: ' 623' isi: 1 language: - iso: eng month: '11' oa: 1 oa_version: Published Version page: 1062-1069 pmid: 1 publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: link: - relation: erratum url: https://doi.org/10.1038/s41586-023-06882-z record: - id: '14472' relation: research_data status: public scopus_import: '1' status: public title: Stress granules plug and stabilize damaged endolysosomal membranes tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 623 year: '2023' ... --- _id: '18189' abstract: - lang: eng text: 'Strongly interacting topological matter1 exhibits fundamentally new phenomena with potential applications in quantum information technology2,3. Emblematic instances are fractional quantum Hall (FQH) states4, in which the interplay of a magnetic field and strong interactions gives rise to fractionally charged quasi-particles, long-ranged entanglement and anyonic exchange statistics. Progress in engineering synthetic magnetic fields5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21 has raised the hope to create these exotic states in controlled quantum systems. However, except for a recent Laughlin state of light22, preparing FQH states in engineered systems remains elusive. Here we realize a FQH state with ultracold atoms in an optical lattice. The state is a lattice version of a bosonic ν = 1/2 Laughlin state4,23 with two particles on 16 sites. This minimal system already captures many hallmark features of Laughlin-type FQH states24,25,26,27,28: we observe a suppression of two-body interactions, we find a distinctive vortex structure in the density correlations and we measure a fractional Hall conductivity of σH/σ0 = 0.6(2) by means of the bulk response to a magnetic perturbation. Furthermore, by tuning the magnetic field, we map out the transition point between the normal and the FQH regime through a spectroscopic investigation of the many-body gap. Our work provides a starting point for exploring highly entangled topological matter with ultracold atoms29,30,31,32,33.' article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Julian full_name: Leonard, Julian id: b75b3f45-7995-11ef-9bfd-9a9cd02c3577 last_name: Leonard - first_name: Sooshin full_name: Kim, Sooshin last_name: Kim - first_name: Joyce full_name: Kwan, Joyce last_name: Kwan - first_name: Perrin full_name: Segura, Perrin last_name: Segura - first_name: Fabian full_name: Grusdt, Fabian last_name: Grusdt - first_name: Cécile full_name: Repellin, Cécile last_name: Repellin - first_name: Nathan full_name: Goldman, Nathan last_name: Goldman - first_name: Markus full_name: Greiner, Markus last_name: Greiner citation: ama: Leonard J, Kim S, Kwan J, et al. Realization of a fractional quantum Hall state with ultracold atoms. Nature. 2023;619(7970):495-499. doi:10.1038/s41586-023-06122-4 apa: Leonard, J., Kim, S., Kwan, J., Segura, P., Grusdt, F., Repellin, C., … Greiner, M. (2023). Realization of a fractional quantum Hall state with ultracold atoms. Nature. Springer Nature. https://doi.org/10.1038/s41586-023-06122-4 chicago: Leonard, Julian, Sooshin Kim, Joyce Kwan, Perrin Segura, Fabian Grusdt, Cécile Repellin, Nathan Goldman, and Markus Greiner. “Realization of a Fractional Quantum Hall State with Ultracold Atoms.” Nature. Springer Nature, 2023. https://doi.org/10.1038/s41586-023-06122-4. ieee: J. Leonard et al., “Realization of a fractional quantum Hall state with ultracold atoms,” Nature, vol. 619, no. 7970. Springer Nature, pp. 495–499, 2023. ista: Leonard J, Kim S, Kwan J, Segura P, Grusdt F, Repellin C, Goldman N, Greiner M. 2023. Realization of a fractional quantum Hall state with ultracold atoms. Nature. 619(7970), 495–499. mla: Leonard, Julian, et al. “Realization of a Fractional Quantum Hall State with Ultracold Atoms.” Nature, vol. 619, no. 7970, Springer Nature, 2023, pp. 495–99, doi:10.1038/s41586-023-06122-4. short: J. Leonard, S. Kim, J. Kwan, P. Segura, F. Grusdt, C. Repellin, N. Goldman, M. Greiner, Nature 619 (2023) 495–499. date_created: 2024-10-07T11:46:13Z date_published: 2023-06-21T00:00:00Z date_updated: 2024-10-08T11:09:24Z day: '21' doi: 10.1038/s41586-023-06122-4 extern: '1' external_id: arxiv: - '2210.10919' pmid: - '37344594 ' intvolume: ' 619' issue: '7970' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2210.10919 month: '06' oa: 1 oa_version: Preprint page: 495-499 pmid: 1 publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: Realization of a fractional quantum Hall state with ultracold atoms type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 619 year: '2023' ...