[{"abstract":[{"lang":"eng","text":"There may be a newly identified early phase of supermassive black hole growth"}],"scopus_import":"1","citation":{"ieee":"J. J. Matthee, “Black holes disguised as little red dots,” <i>Science</i>, vol. 391, no. 6787. AAAS, pp. 767–768, 2026.","ama":"Matthee JJ. Black holes disguised as little red dots. <i>Science</i>. 2026;391(6787):767-768. doi:<a href=\"https://doi.org/10.1126/science.adz8603\">10.1126/science.adz8603</a>","chicago":"Matthee, Jorryt J. “Black Holes Disguised as Little Red Dots.” <i>Science</i>. AAAS, 2026. <a href=\"https://doi.org/10.1126/science.adz8603\">https://doi.org/10.1126/science.adz8603</a>.","apa":"Matthee, J. J. (2026). Black holes disguised as little red dots. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.adz8603\">https://doi.org/10.1126/science.adz8603</a>","short":"J.J. Matthee, Science 391 (2026) 767–768.","ista":"Matthee JJ. 2026. Black holes disguised as little red dots. Science. 391(6787), 767–768.","mla":"Matthee, Jorryt J. “Black Holes Disguised as Little Red Dots.” <i>Science</i>, vol. 391, no. 6787, AAAS, 2026, pp. 767–68, doi:<a href=\"https://doi.org/10.1126/science.adz8603\">10.1126/science.adz8603</a>."},"oa_version":"None","publisher":"AAAS","OA_type":"closed access","status":"public","type":"journal_article","publication_identifier":{"eissn":["1095-9203"]},"volume":391,"date_published":"2026-02-19T00:00:00Z","article_processing_charge":"No","acknowledgement":"The author acknowledges the support from the European Union (European Research Council, AGENTS, 101076224).","title":"Black holes disguised as little red dots","date_updated":"2026-03-02T09:15:45Z","quality_controlled":"1","external_id":{"pmid":["41712710"]},"month":"02","pmid":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"21371","issue":"6787","department":[{"_id":"JoMa"}],"page":"767-768","day":"19","publication":"Science","corr_author":"1","year":"2026","article_type":"comment","date_created":"2026-03-01T23:01:39Z","language":[{"iso":"eng"}],"author":[{"full_name":"Matthee, Jorryt J","id":"7439a258-f3c0-11ec-9501-9df22fe06720","orcid":"0000-0003-2871-127X","first_name":"Jorryt J","last_name":"Matthee"}],"intvolume":"       391","publication_status":"published","project":[{"_id":"bd9b2118-d553-11ed-ba76-db24564edfea","grant_number":"101076224","name":"Young galaxies as tracers and agents of cosmic reionization"}],"doi":"10.1126/science.adz8603"},{"quality_controlled":"1","date_updated":"2026-04-28T13:29:05Z","external_id":{"pmid":["41990175"]},"month":"04","volume":392,"acknowledged_ssus":[{"_id":"Bio"},{"_id":"ScienComp"},{"_id":"EM-Fac"},{"_id":"LifeSc"}],"date_published":"2026-04-16T00:00:00Z","article_processing_charge":"No","acknowledgement":"We thank all members of the Loose lab at ISTA for helpful discussions; M. Kojic for critical reading of the manuscript; A. Herrero (Sevilla University) for sharing her extensive BACTH plasmid library and other plasmids, as well as cyanobacterial strains; T. Dagan and F. Nies (both Kiel University) for sharing cyanobacterial strains and plasmids and for valuable discussions; N. Sapay and A. Michon for providing the Amphipaseek code, which enabled us to perform our large-scale amphipathic helix screen of cyanobacterial CorR proteins; V.-V. Hodirnau for support in cryo-ET data collection; and J. Hansen for advice about cryo-EM data processing.\r\nThis work was supported by the Scientific Service Units (SSU) of ISTA through resources provided by the Imaging & Optics Facility (IOF), the Scientific Computing (SciComp), the Electron Microscopy Facility (EMF), and the Lab Support Facility (LSF). This work was funded by the European Union’s Horizon 2020 research and innovation program (Marie Skłodowska-Curie grant 101034413 to B.L.S.); the European Research Council (ERC) of the European Union (grant ActinID 101076260 to F.K.M.S.); the Swiss National Science Foundation (starting grant TMSGI3_226208 to G.L.W.); and the Jean-Jacques et Letitia Lopez-Loreta Foundation (G.L.W.).","title":"Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape","OA_type":"closed access","status":"public","type":"journal_article","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"citation":{"apa":"Springstein, B. L., Javoor, M., Megrian, D., Hajdu, R., Hanke, D. M., Zens, B., … Loose, M. (2026). Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.aea6343\">https://doi.org/10.1126/science.aea6343</a>","chicago":"Springstein, Benjamin L, Manjunath Javoor, Daniela Megrian, Roman Hajdu, Dustin M. Hanke, Bettina Zens, Gregor L. Weiss, Florian KM Schur, and Martin Loose. “Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling Cell Shape.” <i>Science</i>. AAAS, 2026. <a href=\"https://doi.org/10.1126/science.aea6343\">https://doi.org/10.1126/science.aea6343</a>.","mla":"Springstein, Benjamin L., et al. “Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling Cell Shape.” <i>Science</i>, vol. 392, no. 6795, eaea6343, AAAS, 2026, doi:<a href=\"https://doi.org/10.1126/science.aea6343\">10.1126/science.aea6343</a>.","short":"B.L. Springstein, M. Javoor, D. Megrian, R. Hajdu, D.M. Hanke, B. Zens, G.L. Weiss, F.K. Schur, M. Loose, Science 392 (2026).","ista":"Springstein BL, Javoor M, Megrian D, Hajdu R, Hanke DM, Zens B, Weiss GL, Schur FK, Loose M. 2026. Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. Science. 392(6795), eaea6343.","ieee":"B. L. Springstein <i>et al.</i>, “Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape,” <i>Science</i>, vol. 392, no. 6795. AAAS, 2026.","ama":"Springstein BL, Javoor M, Megrian D, et al. Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. <i>Science</i>. 2026;392(6795). doi:<a href=\"https://doi.org/10.1126/science.aea6343\">10.1126/science.aea6343</a>"},"scopus_import":"1","abstract":[{"text":"Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low–copy number plasmids. In multicellular cyanobacteria such as Anabaena sp., we found that a chromosomally encoded ParMR system has evolved into a cytoskeletal system named CorMR with a function in cell shape control rather than DNA segregation. Live-cell imaging, in vitro reconstitution, and cryo–electron microscopy revealed that CorM formed dynamically unstable, antiparallel double-stranded filaments that were recruited to the membrane by CorR through an amphipathic helix conserved in multicellular cyanobacteria. CorMR filaments were regulated by MinC, which excluded them from the poles and division plane. Comparative genomics indicated that the repurposing of ParMR and Min systems coevolved with cyanobacterial multicellularity, highlighting the evolutionary plasticity of cytoskeletal systems in bacteria.","lang":"eng"}],"article_number":"eaea6343","oa_version":"None","publisher":"AAAS","language":[{"iso":"eng"}],"author":[{"id":"b4eb62ef-ac72-11ed-9503-ed3b4d66c083","full_name":"Springstein, Benjamin L","first_name":"Benjamin L","last_name":"Springstein","orcid":"0000-0002-3461-5391"},{"last_name":"Javoor","first_name":"Manjunath","orcid":"0000-0003-2311-2112","id":"305ab18b-dc7d-11ea-9b2f-b58195228ea2","full_name":"Javoor, Manjunath"},{"last_name":"Megrian","first_name":"Daniela","full_name":"Megrian, Daniela"},{"last_name":"Hajdu","first_name":"Roman","full_name":"Hajdu, Roman","id":"ffab949d-133f-11ed-8f02-94de21ace503"},{"full_name":"Hanke, Dustin M.","last_name":"Hanke","first_name":"Dustin M."},{"orcid":"0000-0002-9561-1239","last_name":"Zens","first_name":"Bettina","full_name":"Zens, Bettina","id":"45FD126C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Weiss, Gregor L.","first_name":"Gregor L.","last_name":"Weiss"},{"id":"48AD8942-F248-11E8-B48F-1D18A9856A87","full_name":"Schur, Florian Km","first_name":"Florian Km","last_name":"Schur","orcid":"0000-0003-4790-8078"},{"full_name":"Loose, Martin","id":"462D4284-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-7309-9724","last_name":"Loose","first_name":"Martin"}],"intvolume":"       392","publication_status":"published","doi":"10.1126/science.aea6343","project":[{"grant_number":"101034413","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program","call_identifier":"H2020"},{"_id":"bd980d18-d553-11ed-ba76-ceaa645c97eb","grant_number":"101076260","name":"A molecular atlas of Actin filament IDentities in the cell motility machinery"}],"year":"2026","article_type":"original","date_created":"2026-04-26T22:01:46Z","day":"16","publication":"Science","corr_author":"1","pmid":1,"_id":"21762","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"6795","ec_funded":1,"department":[{"_id":"MaLo"},{"_id":"FlSc"},{"_id":"GradSch"},{"_id":"EM-Fac"}]},{"acknowledgement":"We gratefully acknowledge the Lab Support Facility (LSF) and the Imaging and Optics Facility (IOF) (both of ISTA) and the Hounsfield CT Facility (University of Nottingham) for support with imaging and the Growth Facility (IPMB) for plant cultivation. We thank M. Fendrych and his team for help with the microfluidics upgrades and J. Atkinson at the University of Nottingham MakerSpace for 3D printing of Arabidopsis mini-soil columns.\r\nThis project received funding from the European Research Council (ERC; 101142681 CYNIPS) and the Austrian Science Fund (FWF; P 37051-B). I.K. was cofunded by the European Union, Horizon Europe, project MOLIPEC, ID 101087030 and CSF project 25-16449S. L.V. and B.K.P. acknowledge funding from UK Research and Innovation (UKRI) Frontiers Research (EP/Y036697/1). M.J.B. acknowledges funding from ERC SYNERGY (grant 101118769 HYDROSENSING). The study was partially supported by the Université Paris Cité, Idex ANR-18-IDEX-0001, funded by the French Government through its “Investments for the Future” program and also by the projects “Mecha-Nuc” ANR-20-CE13-0025-03 and “scEm-bryoMech” ANR-21-CE13-0046. P.D. acknowledges support by Human Frontier Science Program Organization grant 2022-RG107. P.V. acknowledges support provided by “Programme blanc” of the Graduate School BIOSPHERA, Université Paris-Saclay. Phytohormonal analysis was performed using the service laboratory funded by Toward Next GENeration Crops, reg. no. CZ.02.01.01/00/22_008/0004581 of the European Regional Development Fund (ERDF) program Johannes Amos Comenius. This research was funded in whole or in part by the Austrian Science Fund (P 37051-B) and UK Research and Innovation (EP/Y036697/1), cOAlition S organizations, and by the European Research Council (101142681 CYNIPS, 101118769 HYDROSENSING); as required, the author will make the Author Accepted Manuscript (AAM) version available under a CC BY public copyright license.","article_processing_charge":"No","date_published":"2026-04-16T00:00:00Z","title":"Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation","acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"}],"volume":392,"month":"04","quality_controlled":"1","date_updated":"2026-05-07T06:20:07Z","external_id":{"pmid":["41990180"]},"publisher":"AAAS","oa_version":"Accepted Version","scopus_import":"1","citation":{"ieee":"I. Kulich <i>et al.</i>, “Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation,” <i>Science</i>, vol. 392, no. 6795. AAAS, pp. 296–300, 2026.","ama":"Kulich I, Vladimirtsev D, Randuch M, et al. Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation. <i>Science</i>. 2026;392(6795):296-300. doi:<a href=\"https://doi.org/10.1126/science.adu8197\">10.1126/science.adu8197</a>","apa":"Kulich, I., Vladimirtsev, D., Randuch, M., Gao, S., Citterico, M., Konrad, K. R., … Friml, J. (2026). Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.adu8197\">https://doi.org/10.1126/science.adu8197</a>","chicago":"Kulich, Ivan, Dmitrii Vladimirtsev, Marek Randuch, Shiqiang Gao, Matteo Citterico, Kai R. Konrad, Georg Nagel, et al. “Calcium-Triggered Apoplastic ROS Bursts Balance Gravity and Mechanical Signals for Soil Navigation.” <i>Science</i>. AAAS, 2026. <a href=\"https://doi.org/10.1126/science.adu8197\">https://doi.org/10.1126/science.adu8197</a>.","mla":"Kulich, Ivan, et al. “Calcium-Triggered Apoplastic ROS Bursts Balance Gravity and Mechanical Signals for Soil Navigation.” <i>Science</i>, vol. 392, no. 6795, AAAS, 2026, pp. 296–300, doi:<a href=\"https://doi.org/10.1126/science.adu8197\">10.1126/science.adu8197</a>.","ista":"Kulich I, Vladimirtsev D, Randuch M, Gao S, Citterico M, Konrad KR, Nagel G, Wrzaczek M, Cascaro L, Vinet P, Durand P, Asnacios A, Verma L, Bennett MJ, Pandey BK, Friml J. 2026. Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation. Science. 392(6795), 296–300.","short":"I. Kulich, D. Vladimirtsev, M. Randuch, S. Gao, M. Citterico, K.R. Konrad, G. Nagel, M. Wrzaczek, L. Cascaro, P. Vinet, P. Durand, A. Asnacios, L. Verma, M.J. Bennett, B.K. Pandey, J. Friml, Science 392 (2026) 296–300."},"abstract":[{"lang":"eng","text":"Reactive oxygen species (ROS) have been implicated in multiple signaling processes in plants, but the underlying mechanisms and roles remain enigmatic. In this study, we developed a method of live imaging of apoplastic ROS at the root surface. Distinct signals, including auxin, extracellular adenosine triphosphate, and rapid alkalinization factor 1 peptide, induce cytosolic calcium transients and apoplastic ROS bursts. Genetic and optogenetic manipulations of Arabidopsis identified calcium transients as necessary and sufficient for ROS bursts through activation of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidases RBOHC and RBOHF. Apoplastic ROS bursts are not required, but they do limit gravity-induced root bending. Root bending is sensed by the stretch-activated calcium channel MCA1, leading to NADPH oxidase activation. The resulting ROS production stiffens cell walls to facilitate soil penetration. Apoplastic ROS thus provides a means to balance tissue flexibility and stiffness to navigate soil."}],"status":"public","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"type":"journal_article","OA_type":"green","article_type":"original","date_created":"2026-04-26T22:01:47Z","year":"2026","intvolume":"       392","doi":"10.1126/science.adu8197","project":[{"name":"Cyclic nucleotides as second messengers in plants","_id":"8f347782-16d5-11f0-9cad-8c19706ee739","grant_number":"101142681"},{"_id":"7bcece63-9f16-11ee-852c-ae94e099eeb6","grant_number":"P37051","name":"Guanylate cyclase activity of TIR1/AFBs auxin receptors"}],"file":[{"date_created":"2026-05-07T05:54:43Z","file_id":"21832","success":1,"creator":"dernst","checksum":"eb5b29247832ecdc53c8146da0509bbe","access_level":"open_access","file_name":"2026_Science_Kulich_accepted.pdf","file_size":6150733,"date_updated":"2026-05-07T05:54:43Z","relation":"main_file","content_type":"application/pdf"}],"publication_status":"published","oa":1,"author":[{"first_name":"Ivan","last_name":"Kulich","full_name":"Kulich, Ivan","id":"57a1567c-8314-11eb-9063-c9ddc3451a54"},{"full_name":"Vladimirtsev, Dmitrii","id":"60466724-5355-11ee-ae5a-fa55e8f99c3d","last_name":"Vladimirtsev","first_name":"Dmitrii"},{"full_name":"Randuch, Marek","id":"6ac4636d-15b2-11ec-abd3-fb8df79972ae","last_name":"Randuch","first_name":"Marek"},{"last_name":"Gao","first_name":"Shiqiang","full_name":"Gao, Shiqiang"},{"full_name":"Citterico, Matteo","last_name":"Citterico","first_name":"Matteo"},{"last_name":"Konrad","first_name":"Kai R.","full_name":"Konrad, Kai R."},{"full_name":"Nagel, Georg","last_name":"Nagel","first_name":"Georg"},{"full_name":"Wrzaczek, Michael","first_name":"Michael","last_name":"Wrzaczek"},{"full_name":"Cascaro, Léa","first_name":"Léa","last_name":"Cascaro"},{"full_name":"Vinet, Pauline","first_name":"Pauline","last_name":"Vinet"},{"first_name":"Pauline","last_name":"Durand","full_name":"Durand, Pauline"},{"first_name":"Atef","last_name":"Asnacios","full_name":"Asnacios, Atef"},{"full_name":"Verma, Lokesh","first_name":"Lokesh","last_name":"Verma"},{"first_name":"Malcolm J.","last_name":"Bennett","full_name":"Bennett, Malcolm J."},{"full_name":"Pandey, Bipin K.","last_name":"Pandey","first_name":"Bipin K."},{"orcid":"0000-0002-8302-7596","last_name":"Friml","first_name":"Jiří","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"language":[{"iso":"eng"}],"ddc":["580"],"file_date_updated":"2026-05-07T05:54:43Z","has_accepted_license":"1","page":"296-300","pmid":1,"department":[{"_id":"JiFr"},{"_id":"GradSch"}],"issue":"6795","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"21763","publication":"Science","corr_author":"1","OA_place":"repository","day":"16"},{"day":"09","researchdata_availability":"yes","publication":"Science","pmid":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","_id":"22315","issue":"6807","department":[{"_id":"JiFr"}],"language":[{"iso":"eng"}],"author":[{"full_name":"Bao, Zhulatai","first_name":"Zhulatai","last_name":"Bao"},{"full_name":"Wang, Huihui","last_name":"Wang","first_name":"Huihui"},{"full_name":"Zhang, Ai","first_name":"Ai","last_name":"Zhang"},{"full_name":"Gao, Ruxi","last_name":"Gao","first_name":"Ruxi"},{"last_name":"Gu","first_name":"Wen","full_name":"Gu, Wen"},{"full_name":"Fan, Ni","last_name":"Fan","first_name":"Ni"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří","first_name":"Jiří","last_name":"Friml","orcid":"0000-0002-8302-7596"},{"full_name":"Zhang, Yuzhou","first_name":"Yuzhou","last_name":"Zhang"}],"dataavailabilitystatement":"All data are available in the manuscript or the supplementary materials. The raw RNA-seq data have been deposited in the NCBI Gene Expression Omnibus (GEO) under accession number GSE315473. Microbiome sequencing data have been deposited in the Sequence Read Archive (SRA) under BioProject number PRJNA1397137. Materials are available upon request from the corresponding author.","intvolume":"       393","publication_status":"published","project":[{"grant_number":"101142681","_id":"8f347782-16d5-11f0-9cad-8c19706ee739","name":"Cyclic nucleotides as second messengers in plants"},{"grant_number":"P37051","_id":"7bcece63-9f16-11ee-852c-ae94e099eeb6","name":"Guanylate cyclase activity of TIR1/AFBs auxin receptors"}],"doi":"10.1126/science.adw6568","year":"2026","article_type":"original","date_created":"2026-07-13T14:57:10Z","supplementarymaterial":"yes","related_material":{"link":[{"url":"https://ista.ac.at/en/news/roots-steer-clear-of-plant-rot/","description":"News on ISTA website","relation":"press_release"}]},"OA_type":"closed access","status":"public","type":"journal_article","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"abstract":[{"text":"Plant tropisms enable roots to navigate complex soils by responding to directional environmental cues. Biological decay, although central to nutrient cycling, also creates microbially active and potentially hostile niches. In this work, we identified “saprotropism,” a previously unrecognized growth response that enables roots to actively bend away from decaying plant-derived matter. Fungal-driven microbial decomposition released organic acids and formed stable pH gradients in surrounding soil, allowing roots to pinpoint decay without direct contact. Root epidermal cells sensed this acidic gradient through the root meristem growth factor peptide-receptor module, converting external pH asymmetry into asymmetric abscisic acid (ABA) distribution. ABA asymmetry drove microtubule reorganization, which was decoded into decay-avoidant root bending. Together, these findings establish microbial decay–derived chemical gradients as an instructive signal for root navigation and expand the framework of microbe-soil-plant communication.","lang":"eng"}],"article_number":"eadw6568","citation":{"ama":"Bao Z, Wang H, Zhang A, et al. Roots navigate around decay regions by sensing local pH gradients. <i>Science</i>. 2026;393(6807). doi:<a href=\"https://doi.org/10.1126/science.adw6568\">10.1126/science.adw6568</a>","ieee":"Z. Bao <i>et al.</i>, “Roots navigate around decay regions by sensing local pH gradients,” <i>Science</i>, vol. 393, no. 6807. American Association for the Advancement of Science, 2026.","short":"Z. Bao, H. Wang, A. Zhang, R. Gao, W. Gu, N. Fan, J. Friml, Y. Zhang, Science 393 (2026).","ista":"Bao Z, Wang H, Zhang A, Gao R, Gu W, Fan N, Friml J, Zhang Y. 2026. Roots navigate around decay regions by sensing local pH gradients. Science. 393(6807), eadw6568.","mla":"Bao, Zhulatai, et al. “Roots Navigate around Decay Regions by Sensing Local PH Gradients.” <i>Science</i>, vol. 393, no. 6807, eadw6568, American Association for the Advancement of Science, 2026, doi:<a href=\"https://doi.org/10.1126/science.adw6568\">10.1126/science.adw6568</a>.","chicago":"Bao, Zhulatai, Huihui Wang, Ai Zhang, Ruxi Gao, Wen Gu, Ni Fan, Jiří Friml, and Yuzhou Zhang. “Roots Navigate around Decay Regions by Sensing Local PH Gradients.” <i>Science</i>. American Association for the Advancement of Science, 2026. <a href=\"https://doi.org/10.1126/science.adw6568\">https://doi.org/10.1126/science.adw6568</a>.","apa":"Bao, Z., Wang, H., Zhang, A., Gao, R., Gu, W., Fan, N., … Zhang, Y. (2026). Roots navigate around decay regions by sensing local pH gradients. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adw6568\">https://doi.org/10.1126/science.adw6568</a>"},"scopus_import":"1","oa_version":"None","das_tickbox":"1","publisher":"American Association for the Advancement of Science","date_updated":"2026-08-04T09:22:49Z","quality_controlled":"1","external_id":{"pmid":["42424472"]},"month":"07","volume":393,"date_published":"2026-07-09T00:00:00Z","article_processing_charge":"No","acknowledgement":"We are grateful to H. Guo and L. Liu (Department of Biology, Southern University of Science and Technology) for providing the rgf1/2/3, rgi1/2/3/4, tpst-1, and pepr1/2 lines. We thank K.-h. Liu (College of Life Science, Northwest A&F University) for generously providing the ABA biosensor nlsABACUS2-400n. We also thank J. Li and J. Chang (School of Life Sciences, Lanzhou University) for providing the ahk2-5/cre1-2, ahp1/2/3, arr16/arr17, and pTCSn::GFP lines. Our thanks further extend to D. Qian, also from the School of Life Sciences at Lanzhou University, for sharing Arabidopsis line pTUB6::mCherry-TUB6. We are grateful to Y. Zhao (CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences) for providing nced3/5, snrk2.2/2.3/2.6, and pyl duodecuple mutants. We also acknowledge the Teaching and Research Core Facility at the College of Life Sciences, Northwest A&F University, particularly N. Fan, for their invaluable technical assistance. We also thank Life Science Research Core Services (LSRCS), Northwest A&F University, for helping with characterization, including CLSM (X. Liu). Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China JYB2025XDXM706 (Y.Z.); Qin Chuangyuan High-level Innovation and Entrepreneurship Talent Program QCYRCXM-2022-237 (Y.Z.); Fundamental Research Funds for the Central Universities K20200168 (Y.Z.); National Natural Science Foundation of China 32570375 (Y.Z.); National Natural Science Foundation of China 32400699 (A.Z.); European Research Council (ERC, CYNIPS) 101142681 (J.F.); Austrian Science Fund (FWF): P 37051-B (J.F.).","title":"Roots navigate around decay regions by sensing local pH gradients"},{"volume":393,"acknowledgement":"The authors thank O. Schwartz and S. Scheres for helpful remarks and discussions; D. Agard, B. Carragher, C. Potter, and P. Olshin for close collaboration; A. Singh, L. Maisenbacher, S. Strasser, and I. Pope for help with mirror inspection; J. Fang, E. Nogales, and J. Hurley for sharing their lab space and assisting with sample preparation; B. Buijsse, W. Hagen, B. Jiang, and T. Coyle at Thermo Fisher Scientific for the design of the custom transfer optics and technical support; G. Long and T. Gutierrez at the UC Berkeley Physics R&D Machine Shop for machining cavity components and tooling. This work was supported by the following: Chan Zuckerberg Initiative award numbers 2021-234606 and 2025-367757, National Institutes of Health grant R01GM126011, Gordon and Betty Moore Foundation grant 9366, Lawrence Berkeley National Laboratory Directed Research and Development Program grant 25-111, and Cooperative Research and Development Agreement award AWD00004352 (to H.M.); National Institutes of Health fellowship F32GM149186 (to P.N.P.).","article_processing_charge":"No","date_published":"2026-07-09T00:00:00Z","title":"Laser phase plate improves structure determination of small proteins by cryo-EM","quality_controlled":"1","date_updated":"2026-08-05T09:27:38Z","external_id":{"pmid":["42275466"]},"month":"07","oa_version":"None","scopus_import":"1","abstract":[{"lang":"eng","text":"Phase plates can, in principle, overcome the poor image contrast in cryo–electron microscopy (cryo-EM) and the resulting limits on the structural reconstruction of small proteins. However, previous designs have been unstable and compromised the high-resolution signal and have thus been unable to surpass results achieved by standard cryo-EM. Here, we show that the laser phase plate (LPP), installed in a modern, custom Titan Krios microscope, enhances the resolution in single-particle reconstruction of small proteins by improving specimen-motion correction and recovery of information from the early frames, as well as particle visualization, three-dimensional classification, and alignment. These advances use standard defocus ranges and reconstruction procedures but open the door to LPP-tailored protocols, offering further improvements by leveraging the LPP demonstrated here."}],"citation":{"ista":"Petrov PN, Zhang JT, Remis J, Axelrod JJ, Cheng H, Cooper ES, Hicklin IK, Sandhaus S, Schnurr C, Glaeser RM, Müller H. 2026. Laser phase plate improves structure determination of small proteins by cryo-EM. Science. 393(6807), 195–196.","short":"P.N. Petrov, J.T. Zhang, J. Remis, J.J. Axelrod, H. Cheng, E.S. Cooper, I.K. Hicklin, S. Sandhaus, C. Schnurr, R.M. Glaeser, H. Müller, Science 393 (2026) 195–196.","mla":"Petrov, Petar N., et al. “Laser Phase Plate Improves Structure Determination of Small Proteins by Cryo-EM.” <i>Science</i>, vol. 393, no. 6807, AAAS, 2026, pp. 195–96, doi:<a href=\"https://doi.org/10.1126/science.aeh0665\">10.1126/science.aeh0665</a>.","chicago":"Petrov, Petar N, Jessie T. Zhang, Jonathan Remis, Jeremy J. Axelrod, Hang Cheng, Eric S. Cooper, Ian K. Hicklin, et al. “Laser Phase Plate Improves Structure Determination of Small Proteins by Cryo-EM.” <i>Science</i>. AAAS, 2026. <a href=\"https://doi.org/10.1126/science.aeh0665\">https://doi.org/10.1126/science.aeh0665</a>.","apa":"Petrov, P. N., Zhang, J. T., Remis, J., Axelrod, J. J., Cheng, H., Cooper, E. S., … Müller, H. (2026). Laser phase plate improves structure determination of small proteins by cryo-EM. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.aeh0665\">https://doi.org/10.1126/science.aeh0665</a>","ama":"Petrov PN, Zhang JT, Remis J, et al. Laser phase plate improves structure determination of small proteins by cryo-EM. <i>Science</i>. 2026;393(6807):195-196. doi:<a href=\"https://doi.org/10.1126/science.aeh0665\">10.1126/science.aeh0665</a>","ieee":"P. N. Petrov <i>et al.</i>, “Laser phase plate improves structure determination of small proteins by cryo-EM,” <i>Science</i>, vol. 393, no. 6807. AAAS, pp. 195–196, 2026."},"das_tickbox":"1","publisher":"AAAS","supplementarymaterial":"yes","OA_type":"closed access","status":"public","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"type":"journal_article","year":"2026","article_type":"original","date_created":"2026-07-19T22:01:46Z","author":[{"id":"b1d6732d-8cb6-11f0-baab-bd460ee3a287","full_name":"Petrov, Petar N","last_name":"Petrov","first_name":"Petar N"},{"last_name":"Zhang","first_name":"Jessie T.","full_name":"Zhang, Jessie T."},{"full_name":"Remis, Jonathan","first_name":"Jonathan","last_name":"Remis"},{"last_name":"Axelrod","first_name":"Jeremy J.","full_name":"Axelrod, Jeremy J."},{"full_name":"Cheng, Hang","last_name":"Cheng","first_name":"Hang"},{"first_name":"Eric S.","last_name":"Cooper","full_name":"Cooper, Eric S."},{"first_name":"Ian K.","last_name":"Hicklin","full_name":"Hicklin, Ian K."},{"last_name":"Sandhaus","first_name":"Shahar","full_name":"Sandhaus, Shahar"},{"first_name":"Cooper","last_name":"Schnurr","full_name":"Schnurr, Cooper"},{"full_name":"Glaeser, Robert M.","last_name":"Glaeser","first_name":"Robert M."},{"first_name":"Holger","last_name":"Müller","full_name":"Müller, Holger"}],"ddc":["570"],"language":[{"iso":"eng"}],"dataavailabilitystatement":"The datasets are publicly available in the Electron Microscopy Public Image Archive [A1: EMPIAR-13528 (on), EMPIAR-13527 (off); A2: EMPIAR-13529 (on), EMPIAR-13526 (off); A3: EMPIAR-13530 (on), EMPIAR-13525 (off); H1: EMPIAR-13535 (on), EMPIAR-13533 (off); H2: EMPIAR-13534 (on), EMPIAR-13532 (off); H3: EMPIAR-13537 (on), EMPIAR-13531 (off)]. The final reconstructed maps are deposited in the Electron Microscopy Data Bank [A1: EMD-76790 (on), EMD-76791 (off); A2: EMD-76792 (on), EMD-76793 (off); A3: EMD-76794 (on), EMD-76797 (off); H1: EMD-76802 (on), EMD-76804 (off); H2: EMD-76805 (on), EMD-76806 (off); H3: EMD-76807 (on), EMD-76809 (off)]. The initial structures in Fig. 3 are deposited at EMD-76810 (on) and EMD-76811 (off). Code for converting EER movies to binned TIF format with proper accounting for electron dose is deposited in Zenodo (47) and available on GitHub at https://github.com/matterwaves/eer2tiff/releases/tag/v0.1.0. All specimen preparation materials are commercially available.","intvolume":"       393","doi":"10.1126/science.aeh0665","publication_status":"published","pmid":1,"issue":"6807","department":[{"_id":"MiLe"}],"_id":"22365","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","has_accepted_license":"1","page":"195-196","researchdata_availability":"yes","day":"09","publication":"Science"},{"language":[{"iso":"eng"}],"author":[{"full_name":"Chen, Liangzhi","first_name":"Liangzhi","last_name":"Chen"},{"first_name":"Philipp","last_name":"Brun","full_name":"Brun, Philipp"},{"first_name":"Pascal","last_name":"Buri","id":"317987aa-9421-11ee-ac5a-b941b041abba","full_name":"Buri, Pascal"},{"full_name":"Fatichi, Simone","last_name":"Fatichi","first_name":"Simone"},{"full_name":"Gessler, Arthur","first_name":"Arthur","last_name":"Gessler"},{"id":"22a2674a-61ce-11ee-94b5-d18813baf16f","full_name":"Mccarthy, Michael","last_name":"Mccarthy","first_name":"Michael"},{"orcid":"0000-0002-5554-8087","first_name":"Francesca","last_name":"Pellicciotti","full_name":"Pellicciotti, Francesca","id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70"},{"first_name":"Benjamin","last_name":"Stocker","full_name":"Stocker, Benjamin"},{"last_name":"Karger","first_name":"Dirk Nikolaus","full_name":"Karger, Dirk Nikolaus"}],"publication_status":"published","doi":"10.1126/science.ado4245","intvolume":"       387","year":"2025","date_created":"2025-02-02T23:01:54Z","article_type":"original","day":"17","publication":"Science","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","_id":"18985","issue":"6731","department":[{"_id":"FrPe"}],"pmid":1,"page":"278-284","external_id":{"isi":["001491931700027"],"pmid":["39818908"]},"date_updated":"2025-09-30T10:24:34Z","quality_controlled":"1","month":"01","volume":387,"title":"Global increase in the occurrence and impact of multiyear droughts","date_published":"2025-01-17T00:00:00Z","article_processing_charge":"No","isi":1,"acknowledgement":"This study received support from the Extremes Research Program funded by the Swiss Federal Institute for Forest, Snow and Landscape Research (WSL) within the EMERGE project of the Extremes program.","OA_type":"closed access","type":"journal_article","publication_identifier":{"eissn":["1095-9203"]},"status":"public","abstract":[{"text":"Persistent multiyear drought (MYD) events pose a growing threat to nature and humans in a changing climate. We identified and inventoried global MYDs by detecting spatiotemporally contiguous climatic anomalies, showing that MYDs have become drier, hotter, and led to increasingly diminished vegetation greenness. The global terrestrial land affected by MYDs has increased at a rate of 49,279 ± 14,771 square kilometers per year from 1980 to 2018. Temperate grasslands have exhibited the greatest declines in vegetation greenness during MYDs, whereas boreal and tropical forests have had comparably minor responses. With MYDs becoming more common, this global quantitative inventory of the occurrence, severity, trend, and impact of MYDs provides an important benchmark for facilitating more effective and collaborative preparedness toward mitigation of and adaptation to such extreme events.","lang":"eng"}],"scopus_import":"1","citation":{"apa":"Chen, L., Brun, P., Buri, P., Fatichi, S., Gessler, A., McCarthy, M., … Karger, D. N. (2025). Global increase in the occurrence and impact of multiyear droughts. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.ado4245\">https://doi.org/10.1126/science.ado4245</a>","chicago":"Chen, Liangzhi, Philipp Brun, Pascal Buri, Simone Fatichi, Arthur Gessler, Michael McCarthy, Francesca Pellicciotti, Benjamin Stocker, and Dirk Nikolaus Karger. “Global Increase in the Occurrence and Impact of Multiyear Droughts.” <i>Science</i>. AAAS, 2025. <a href=\"https://doi.org/10.1126/science.ado4245\">https://doi.org/10.1126/science.ado4245</a>.","mla":"Chen, Liangzhi, et al. “Global Increase in the Occurrence and Impact of Multiyear Droughts.” <i>Science</i>, vol. 387, no. 6731, AAAS, 2025, pp. 278–84, doi:<a href=\"https://doi.org/10.1126/science.ado4245\">10.1126/science.ado4245</a>.","ista":"Chen L, Brun P, Buri P, Fatichi S, Gessler A, McCarthy M, Pellicciotti F, Stocker B, Karger DN. 2025. Global increase in the occurrence and impact of multiyear droughts. Science. 387(6731), 278–284.","short":"L. Chen, P. Brun, P. Buri, S. Fatichi, A. Gessler, M. McCarthy, F. Pellicciotti, B. Stocker, D.N. Karger, Science 387 (2025) 278–284.","ieee":"L. Chen <i>et al.</i>, “Global increase in the occurrence and impact of multiyear droughts,” <i>Science</i>, vol. 387, no. 6731. AAAS, pp. 278–284, 2025.","ama":"Chen L, Brun P, Buri P, et al. Global increase in the occurrence and impact of multiyear droughts. <i>Science</i>. 2025;387(6731):278-284. doi:<a href=\"https://doi.org/10.1126/science.ado4245\">10.1126/science.ado4245</a>"},"oa_version":"None","publisher":"AAAS"},{"author":[{"id":"12ab8624-4c8a-11ec-9e11-e1ac2438f22f","full_name":"Xu, Shengduo","last_name":"Xu","first_name":"Shengduo"},{"first_name":"Sharona","last_name":"Horta","full_name":"Horta, Sharona","id":"03a7e858-01b1-11ec-8b71-99ae6c4a05bc"},{"id":"5bdaf946-5355-11ee-ae5a-8061700bd605","full_name":"Lawal, Abayomi Q","first_name":"Abayomi Q","last_name":"Lawal"},{"id":"76bc9e9f-ba0b-11ee-8184-90edabd17a58","full_name":"Maji, Krishnendu","first_name":"Krishnendu","last_name":"Maji"},{"last_name":"Lorion","first_name":"Magali","full_name":"Lorion, Magali","id":"bc07ac4d-142e-11eb-a9d5-d72db792859d"},{"orcid":"0000-0001-5013-2843","last_name":"Ibáñez","first_name":"Maria","full_name":"Ibáñez, Maria","id":"43C61214-F248-11E8-B48F-1D18A9856A87"}],"language":[{"iso":"eng"}],"doi":"10.1126/science.ads0426","project":[{"name":"HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery","_id":"9B8F7476-BA93-11EA-9121-9846C619BF3A"}],"publication_status":"published","intvolume":"       387","year":"2025","date_created":"2025-03-09T23:01:26Z","article_type":"original","day":"20","corr_author":"1","publication":"Science","issue":"6736","department":[{"_id":"MaIb"}],"_id":"19364","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","pmid":1,"page":"845-850","external_id":{"isi":["001514422600026"],"pmid":["39977506"]},"date_updated":"2026-04-28T13:43:53Z","quality_controlled":"1","month":"02","acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"LifeSc"},{"_id":"M-Shop"},{"_id":"NanoFab"}],"volume":387,"title":"Interfacial bonding enhances thermoelectric cooling in 3D-printed materials","acknowledgement":"This work was supported by the Scientific Service Units (SSU) of ISTA through resources provided by the Electron Microscopy Facility (EMF), the Lab Support Facility (LSF), the Communication & Events facility, the Miba Machine Shop, and the Nanofabrication Facility (NNF). The Mechanical Response of Materials (MRM) Service Unit of the Technical University of Wien is acknowledged for Mechanical tests. X. L. Yan and S. Bühler-Paschen (Institute of Solid-State Physics, Technical University of Wien) are acknowledged for granting us access to their equipment, which allowed us to perform independent corroborative measurements. M. Qin is acknowledged for help with Au deposition and wire bonding for samples used for PPMS measurements. The lab of B. Hof and Z. Lu is acknowledged for help with rheological properties measurements. The members of the Ibáñez research group, especially N. Jakhar, C. Fiedler, and T. Kleinhanns, are acknowledged for their feedback on the manuscript and fruitful discussions. This work was financially supported by ISTA and the Werner Siemens Foundation.","isi":1,"date_published":"2025-02-20T00:00:00Z","article_processing_charge":"No","related_material":{"link":[{"relation":"press_release","url":"https://ista.ac.at/en/news/cooling-materials-out-of-the-3d-printer/","description":"News on ISTA website"}]},"OA_type":"closed access","publication_identifier":{"eissn":["1095-9203"]},"type":"journal_article","status":"public","oa_version":"None","abstract":[{"lang":"eng","text":"Thermoelectric coolers (TECs) are pivotal in modern heat management but face limitations in efficiency and manufacturing scalability. We address these challenges by using an extrusion-based 3D printing technique to fabricate high-performance thermoelectric materials. Our ink formulations ensure the integrity of the 3D-printed structure and effective particle bonding during sintering, achieving record-high figure of merit (zT) values of 1.42 for p-type bismuth antimony telluride [(Bi,Sb)2Te3] and 1.3 for n-type silver selenide (Ag2Se) materials at room temperature. The resulting TEC demonstrates a cooling temperature gradient of 50°C in air. Moreover, this scalable and cost-effective method circumvents energy-intensive and time-consuming steps, such as ingot preparation and subsequently machining processes, offering a transformative solution for thermoelectric device production and heralding a new era of efficient and sustainable thermoelectric technologies."}],"citation":{"ama":"Xu S, Horta S, Lawal AQ, Maji K, Lorion M, Ibáñez M. Interfacial bonding enhances thermoelectric cooling in 3D-printed materials. <i>Science</i>. 2025;387(6736):845-850. doi:<a href=\"https://doi.org/10.1126/science.ads0426\">10.1126/science.ads0426</a>","ieee":"S. Xu, S. Horta, A. Q. Lawal, K. Maji, M. Lorion, and M. Ibáñez, “Interfacial bonding enhances thermoelectric cooling in 3D-printed materials,” <i>Science</i>, vol. 387, no. 6736. AAAS, pp. 845–850, 2025.","mla":"Xu, Shengduo, et al. “Interfacial Bonding Enhances Thermoelectric Cooling in 3D-Printed Materials.” <i>Science</i>, vol. 387, no. 6736, AAAS, 2025, pp. 845–50, doi:<a href=\"https://doi.org/10.1126/science.ads0426\">10.1126/science.ads0426</a>.","ista":"Xu S, Horta S, Lawal AQ, Maji K, Lorion M, Ibáñez M. 2025. Interfacial bonding enhances thermoelectric cooling in 3D-printed materials. Science. 387(6736), 845–850.","short":"S. Xu, S. Horta, A.Q. Lawal, K. Maji, M. Lorion, M. Ibáñez, Science 387 (2025) 845–850.","apa":"Xu, S., Horta, S., Lawal, A. Q., Maji, K., Lorion, M., &#38; Ibáñez, M. (2025). Interfacial bonding enhances thermoelectric cooling in 3D-printed materials. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.ads0426\">https://doi.org/10.1126/science.ads0426</a>","chicago":"Xu, Shengduo, Sharona Horta, Abayomi Q Lawal, Krishnendu Maji, Magali Lorion, and Maria Ibáñez. “Interfacial Bonding Enhances Thermoelectric Cooling in 3D-Printed Materials.” <i>Science</i>. AAAS, 2025. <a href=\"https://doi.org/10.1126/science.ads0426\">https://doi.org/10.1126/science.ads0426</a>."},"scopus_import":"1","publisher":"AAAS"},{"title":"Kiss, shrink, run","date_published":"2025-10-16T00:00:00Z","article_processing_charge":"No","acknowledgement":"The author thanks P. Jonas for feedback on the manuscript and acknowledges support from the European Union’s Horizon 2020 research and innovation program under Marie Skłodowska-Curie grant agreement no. 101034413.","isi":1,"volume":390,"month":"10","external_id":{"isi":["001610669900024"],"pmid":["41100630"]},"quality_controlled":"1","date_updated":"2025-12-01T15:04:34Z","publisher":"AAAS","abstract":[{"text":"A unified mechanism directs synaptic vesicle release","lang":"eng"}],"citation":{"mla":"Lichter, Katharina. “Kiss, Shrink, Run.” <i>Science</i>, vol. 390, no. 6770, AAAS, 2025, pp. 236–37, doi:<a href=\"https://doi.org/10.1126/science.aec0091\">10.1126/science.aec0091</a>.","short":"K. Lichter, Science 390 (2025) 236–237.","ista":"Lichter K. 2025. Kiss, shrink, run. Science. 390(6770), 236–237.","apa":"Lichter, K. (2025). Kiss, shrink, run. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.aec0091\">https://doi.org/10.1126/science.aec0091</a>","chicago":"Lichter, Katharina. “Kiss, Shrink, Run.” <i>Science</i>. AAAS, 2025. <a href=\"https://doi.org/10.1126/science.aec0091\">https://doi.org/10.1126/science.aec0091</a>.","ama":"Lichter K. Kiss, shrink, run. <i>Science</i>. 2025;390(6770):236-237. doi:<a href=\"https://doi.org/10.1126/science.aec0091\">10.1126/science.aec0091</a>","ieee":"K. Lichter, “Kiss, shrink, run,” <i>Science</i>, vol. 390, no. 6770. AAAS, pp. 236–237, 2025."},"scopus_import":"1","oa_version":"None","type":"journal_article","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"status":"public","OA_type":"closed access","date_created":"2025-10-26T23:01:34Z","article_type":"comment","year":"2025","publication_status":"published","doi":"10.1126/science.aec0091","project":[{"call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","grant_number":"101034413"}],"intvolume":"       390","language":[{"iso":"eng"}],"author":[{"full_name":"Lichter, Katharina","id":"39302e62-fcfc-11ec-8196-8b01447dbd3d","orcid":"0000-0002-1485-0351","last_name":"Lichter","first_name":"Katharina"}],"page":"236-237","_id":"20532","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ec_funded":1,"department":[{"_id":"PeJo"}],"issue":"6770","pmid":1,"corr_author":"1","publication":"Science","day":"16"},{"das_tickbox":"1","publisher":"AAAS","oa_version":"None","abstract":[{"lang":"eng","text":"Persistent multiyear drought (MYD) events pose a growing threat to nature and humans in a changing climate. We identified and inventoried global MYDs by detecting spatiotemporally contiguous climatic anomalies, showing that MYDs have become drier, hotter, and led to increasingly diminished vegetation greenness. The global terrestrial land affected by MYDs has increased at a rate of 49,279 ± 14,771 square kilometers per year from 1980 to 2018. Temperate grasslands have exhibited the greatest declines in vegetation greenness during MYDs, whereas boreal and tropical forests have had comparably minor responses. With MYDs becoming more common, this global quantitative inventory of the occurrence, severity, trend, and impact of MYDs provides an important benchmark for facilitating more effective and collaborative preparedness toward mitigation of and adaptation to such extreme events."}],"scopus_import":"1","citation":{"ieee":"L. Chen <i>et al.</i>, “Global increase in the occurrence and impact of multiyear droughts,” <i>Science</i>, vol. 387, no. 6731. AAAS, pp. 278–284, 2025.","ama":"Chen L, Brun P, Buri P, et al. Global increase in the occurrence and impact of multiyear droughts. <i>Science</i>. 2025;387(6731):278-284. doi:<a href=\"https://doi.org/10.1126/science.ado4245\">10.1126/science.ado4245</a>","chicago":"Chen, Liangzhi, Philipp Brun, Pascal Buri, Simone Fatichi, Arthur Gessler, Michael James McCarthy, Francesca Pellicciotti, Benjamin Stocker, and Dirk Nikolaus Karger. “Global Increase in the Occurrence and Impact of Multiyear Droughts.” <i>Science</i>. AAAS, 2025. <a href=\"https://doi.org/10.1126/science.ado4245\">https://doi.org/10.1126/science.ado4245</a>.","apa":"Chen, L., Brun, P., Buri, P., Fatichi, S., Gessler, A., McCarthy, M. J., … Karger, D. N. (2025). Global increase in the occurrence and impact of multiyear droughts. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.ado4245\">https://doi.org/10.1126/science.ado4245</a>","short":"L. Chen, P. Brun, P. Buri, S. Fatichi, A. Gessler, M.J. McCarthy, F. Pellicciotti, B. Stocker, D.N. Karger, Science 387 (2025) 278–284.","ista":"Chen L, Brun P, Buri P, Fatichi S, Gessler A, McCarthy MJ, Pellicciotti F, Stocker B, Karger DN. 2025. Global increase in the occurrence and impact of multiyear droughts. Science. 387(6731), 278–284.","mla":"Chen, Liangzhi, et al. “Global Increase in the Occurrence and Impact of Multiyear Droughts.” <i>Science</i>, vol. 387, no. 6731, AAAS, 2025, pp. 278–84, doi:<a href=\"https://doi.org/10.1126/science.ado4245\">10.1126/science.ado4245</a>."},"status":"public","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"type":"journal_article","OA_type":"closed access","article_processing_charge":"No","date_published":"2025-01-17T00:00:00Z","title":"Global increase in the occurrence and impact of multiyear droughts","volume":387,"month":"01","date_updated":"2026-08-07T10:47:08Z","quality_controlled":"1","page":"278-284","issue":"6731","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","_id":"22562","publication":"Science","day":"17","article_type":"original","date_created":"2026-07-27T12:30:24Z","year":"2025","intvolume":"       387","doi":"10.1126/science.ado4245","extern":"1","publication_status":"published","author":[{"full_name":"Chen, Liangzhi","last_name":"Chen","first_name":"Liangzhi"},{"full_name":"Brun, Philipp","first_name":"Philipp","last_name":"Brun"},{"full_name":"Buri, Pascal","first_name":"Pascal","last_name":"Buri"},{"full_name":"Fatichi, Simone","id":"cf8e546b-a9b0-11f0-a43b-aa89ed1b56d6","last_name":"Fatichi","first_name":"Simone"},{"full_name":"Gessler, Arthur","last_name":"Gessler","first_name":"Arthur"},{"full_name":"McCarthy, Michael James","last_name":"McCarthy","first_name":"Michael James"},{"first_name":"Francesca","last_name":"Pellicciotti","full_name":"Pellicciotti, Francesca"},{"full_name":"Stocker, Benjamin","last_name":"Stocker","first_name":"Benjamin"},{"full_name":"Karger, Dirk Nikolaus","first_name":"Dirk Nikolaus","last_name":"Karger"}],"language":[{"iso":"eng"}]},{"language":[{"iso":"eng"}],"ddc":["540"],"author":[{"last_name":"Yao","first_name":"Yuxing","full_name":"Yao, Yuxing"},{"full_name":"Wilborn, Atalaya Milan","first_name":"Atalaya Milan","last_name":"Wilborn"},{"first_name":"Baptiste","last_name":"Lemaire","full_name":"Lemaire, Baptiste"},{"full_name":"Trigka, Foteini","first_name":"Foteini","last_name":"Trigka"},{"last_name":"Stricker","first_name":"Friedrich J","id":"7aca2cfc-46cf-11f0-abd3-8c96b5186745","full_name":"Stricker, Friedrich J"},{"last_name":"Weible","first_name":"Alan H.","full_name":"Weible, Alan H."},{"full_name":"Li, Shucong","last_name":"Li","first_name":"Shucong"},{"full_name":"Bennett, Robert K. A.","first_name":"Robert K. A.","last_name":"Bennett"},{"full_name":"Cheung, Tung Chun","first_name":"Tung Chun","last_name":"Cheung"},{"full_name":"Grinthal, Alison","last_name":"Grinthal","first_name":"Alison"},{"full_name":"Zhernenkov, Mikhail","last_name":"Zhernenkov","first_name":"Mikhail"},{"first_name":"Guillaume","last_name":"Freychet","full_name":"Freychet, Guillaume"},{"full_name":"Wąsik, Patryk","last_name":"Wąsik","first_name":"Patryk"},{"full_name":"Kozinsky, Boris","last_name":"Kozinsky","first_name":"Boris"},{"first_name":"Michael M.","last_name":"Lerch","full_name":"Lerch, Michael M."},{"first_name":"Xiaoguang","last_name":"Wang","full_name":"Wang, Xiaoguang"},{"first_name":"Joanna","last_name":"Aizenberg","full_name":"Aizenberg, Joanna"}],"intvolume":"       386","extern":"1","publication_status":"published","doi":"10.1126/science.adq6434","year":"2024","article_type":"original","date_created":"2026-05-06T10:54:51Z","day":"06","publication":"Science","pmid":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","_id":"21817","issue":"6726","page":"1161-1168","quality_controlled":"1","date_updated":"2026-05-12T09:48:12Z","external_id":{"pmid":["39636998"]},"month":"12","volume":386,"article_processing_charge":"No","date_published":"2024-12-06T00:00:00Z","title":"Programming liquid crystal elastomers for multistep ambidirectional deformability","OA_type":"closed access","status":"public","type":"journal_article","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"scopus_import":"1","abstract":[{"text":"Ambidirectionality, which is the ability of structural elements to move beyond a reference state in two opposite directions, is common in nature. However, conventional soft materials are typically limited to a single, unidirectional deformation unless complex hybrid constructs are used. We exploited the combination of mesogen self-assembly, polymer chain elasticity, and polymerization-induced stress to design liquid crystalline elastomers that exhibit two mesophases: chevron smectic C (cSmC) and smectic A (SmA). Inducing the cSmC-SmA–isotropic phase transition led to an unusual inversion of the strain field in the microstructure, resulting in opposite deformation modes (e.g., consecutive shrinkage or expansion and right-handed or left-handed twisting and tilting in opposite directions) and high-frequency nonmonotonic oscillations. This ambidirectional movement is scalable and can be used to generate Gaussian transformations at the macroscale.","lang":"eng"}],"citation":{"chicago":"Yao, Yuxing, Atalaya Milan Wilborn, Baptiste Lemaire, Foteini Trigka, Friedrich J Stricker, Alan H. Weible, Shucong Li, et al. “Programming Liquid Crystal Elastomers for Multistep Ambidirectional Deformability.” <i>Science</i>. American Association for the Advancement of Science, 2024. <a href=\"https://doi.org/10.1126/science.adq6434\">https://doi.org/10.1126/science.adq6434</a>.","apa":"Yao, Y., Wilborn, A. M., Lemaire, B., Trigka, F., Stricker, F. J., Weible, A. H., … Aizenberg, J. (2024). Programming liquid crystal elastomers for multistep ambidirectional deformability. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adq6434\">https://doi.org/10.1126/science.adq6434</a>","ista":"Yao Y, Wilborn AM, Lemaire B, Trigka F, Stricker FJ, Weible AH, Li S, Bennett RKA, Cheung TC, Grinthal A, Zhernenkov M, Freychet G, Wąsik P, Kozinsky B, Lerch MM, Wang X, Aizenberg J. 2024. Programming liquid crystal elastomers for multistep ambidirectional deformability. Science. 386(6726), 1161–1168.","short":"Y. Yao, A.M. Wilborn, B. Lemaire, F. Trigka, F.J. Stricker, A.H. Weible, S. Li, R.K.A. Bennett, T.C. Cheung, A. Grinthal, M. Zhernenkov, G. Freychet, P. Wąsik, B. Kozinsky, M.M. Lerch, X. Wang, J. Aizenberg, Science 386 (2024) 1161–1168.","mla":"Yao, Yuxing, et al. “Programming Liquid Crystal Elastomers for Multistep Ambidirectional Deformability.” <i>Science</i>, vol. 386, no. 6726, American Association for the Advancement of Science, 2024, pp. 1161–68, doi:<a href=\"https://doi.org/10.1126/science.adq6434\">10.1126/science.adq6434</a>.","ieee":"Y. Yao <i>et al.</i>, “Programming liquid crystal elastomers for multistep ambidirectional deformability,” <i>Science</i>, vol. 386, no. 6726. American Association for the Advancement of Science, pp. 1161–1168, 2024.","ama":"Yao Y, Wilborn AM, Lemaire B, et al. Programming liquid crystal elastomers for multistep ambidirectional deformability. <i>Science</i>. 2024;386(6726):1161-1168. doi:<a href=\"https://doi.org/10.1126/science.adq6434\">10.1126/science.adq6434</a>"},"oa_version":"None","publisher":"American Association for the Advancement of Science"},{"language":[{"iso":"eng"}],"author":[{"first_name":"David H","last_name":"Vandael","orcid":"0000-0001-7577-1676","id":"3AE48E0A-F248-11E8-B48F-1D18A9856A87","full_name":"Vandael, David H"},{"last_name":"Jonas","first_name":"Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","full_name":"Jonas, Peter M"}],"intvolume":"       383","publication_status":"published","doi":"10.1126/science.adg6757","project":[{"grant_number":"692692","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Biophysics and circuit function of a giant cortical glutamatergic synapse"},{"_id":"25C5A090-B435-11E9-9278-68D0E5697425","grant_number":"Z00312","name":"Synaptic communication in neuronal microcircuits","call_identifier":"FWF"},{"name":"Mechanisms of GABA release in hippocampal circuits","_id":"bd88be38-d553-11ed-ba76-81d5a70a6ef5","grant_number":"P36232"}],"year":"2024","article_type":"review","date_created":"2024-03-17T23:00:57Z","day":"08","publication":"Science","corr_author":"1","pmid":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","_id":"15117","department":[{"_id":"PeJo"}],"ec_funded":1,"issue":"6687","page":"eadg6757","quality_controlled":"1","date_updated":"2025-09-04T13:04:34Z","external_id":{"pmid":["38452088"],"isi":["001216996700015"]},"month":"03","volume":383,"date_published":"2024-03-08T00:00:00Z","article_processing_charge":"No","isi":1,"acknowledgement":"We thank previous students, postdocs, and collaborators, particularly J. Geiger, and (in alphabetical order) H. Alle, J. Bischofberger, C. Borges-Merjane, D. Engel, M. Frotscher, S. Hallermann, M. Heckmann, S. Jamrichova, O. Kim, L. Li, K. Lichter, P. Lin, J. Lübke, Y. Okamoto, C. Pawlu, C. Schmidt-Hieber, N. Spruston, and N. Vyleta for their outstanding experimental contributions. We also thank P. Castillo, J. Geiger, T. Sakaba, S. Siegert, T. Vogels, and J. Watson for critically reading the manuscript, E. Kralli-Beller for text editing, and J. Malikovic and L. Slomianka for useful discussions. We apologize that, due to space constraints, not all relevant papers could be cited.\r\nThis project was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement 692692, AdG “GIANTSYN”) and the Fonds zur Förderung der Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein Award; P 36232-B, stand-alone grant), both to P.J.","title":"Structure, biophysics, and circuit function of a \"giant\" cortical presynaptic terminal","status":"public","type":"journal_article","publication_identifier":{"eissn":["1095-9203"]},"abstract":[{"text":"The hippocampal mossy fiber synapse, formed between axons of dentate gyrus granule cells and dendrites of CA3 pyramidal neurons, is a key synapse in the trisynaptic circuitry of the hippocampus. Because of its comparatively large size, this synapse is accessible to direct presynaptic recording, allowing a rigorous investigation of the biophysical mechanisms of synaptic transmission and plasticity. Furthermore, because of its placement in the very center of the hippocampal memory circuit, this synapse seems to be critically involved in several higher network functions, such as learning, memory, pattern separation, and pattern completion. Recent work based on new technologies in both nanoanatomy and nanophysiology, including presynaptic patch-clamp recording, paired recording, super-resolution light microscopy, and freeze-fracture and “flash-and-freeze” electron microscopy, has provided new insights into the structure, biophysics, and network function of this intriguing synapse. This brings us one step closer to answering a fundamental question in neuroscience: how basic synaptic properties shape higher network computations.","lang":"eng"}],"scopus_import":"1","citation":{"ieee":"D. H. Vandael and P. M. Jonas, “Structure, biophysics, and circuit function of a ‘giant’ cortical presynaptic terminal,” <i>Science</i>, vol. 383, no. 6687. AAAS, p. eadg6757, 2024.","ama":"Vandael DH, Jonas PM. Structure, biophysics, and circuit function of a “giant” cortical presynaptic terminal. <i>Science</i>. 2024;383(6687):eadg6757. doi:<a href=\"https://doi.org/10.1126/science.adg6757\">10.1126/science.adg6757</a>","apa":"Vandael, D. H., &#38; Jonas, P. M. (2024). Structure, biophysics, and circuit function of a “giant” cortical presynaptic terminal. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.adg6757\">https://doi.org/10.1126/science.adg6757</a>","chicago":"Vandael, David H, and Peter M Jonas. “Structure, Biophysics, and Circuit Function of a ‘Giant’ Cortical Presynaptic Terminal.” <i>Science</i>. AAAS, 2024. <a href=\"https://doi.org/10.1126/science.adg6757\">https://doi.org/10.1126/science.adg6757</a>.","mla":"Vandael, David H., and Peter M. Jonas. “Structure, Biophysics, and Circuit Function of a ‘Giant’ Cortical Presynaptic Terminal.” <i>Science</i>, vol. 383, no. 6687, AAAS, 2024, p. eadg6757, doi:<a href=\"https://doi.org/10.1126/science.adg6757\">10.1126/science.adg6757</a>.","ista":"Vandael DH, Jonas PM. 2024. Structure, biophysics, and circuit function of a ‘giant’ cortical presynaptic terminal. Science. 383(6687), eadg6757.","short":"D.H. Vandael, P.M. Jonas, Science 383 (2024) eadg6757."},"oa_version":"None","publisher":"AAAS"},{"volume":383,"isi":1,"acknowledgement":"The authors thank the Werner-Siemens-Stiftung and the Institute of Science and Technology Austria for financial support.","article_processing_charge":"No","date_published":"2024-03-14T00:00:00Z","title":"Electron highways are cooler","quality_controlled":"1","date_updated":"2025-09-04T13:12:19Z","external_id":{"isi":["001273082800019"],"pmid":["38484066"]},"month":"03","oa_version":"None","abstract":[{"lang":"eng","text":"Reducing defects boosts room-temperature performance of a thermoelectric device"}],"citation":{"ieee":"N. Jakhar and M. Ibáñez, “Electron highways are cooler,” <i>Science</i>, vol. 383, no. 6688. American Association for the Advancement of Science, p. 1184, 2024.","ama":"Jakhar N, Ibáñez M. Electron highways are cooler. <i>Science</i>. 2024;383(6688):1184. doi:<a href=\"https://doi.org/10.1126/science.ado4077\">10.1126/science.ado4077</a>","chicago":"Jakhar, Navita, and Maria Ibáñez. “Electron Highways Are Cooler.” <i>Science</i>. American Association for the Advancement of Science, 2024. <a href=\"https://doi.org/10.1126/science.ado4077\">https://doi.org/10.1126/science.ado4077</a>.","apa":"Jakhar, N., &#38; Ibáñez, M. (2024). Electron highways are cooler. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.ado4077\">https://doi.org/10.1126/science.ado4077</a>","short":"N. Jakhar, M. Ibáñez, Science 383 (2024) 1184.","ista":"Jakhar N, Ibáñez M. 2024. Electron highways are cooler. Science. 383(6688), 1184.","mla":"Jakhar, Navita, and Maria Ibáñez. “Electron Highways Are Cooler.” <i>Science</i>, vol. 383, no. 6688, American Association for the Advancement of Science, 2024, p. 1184, doi:<a href=\"https://doi.org/10.1126/science.ado4077\">10.1126/science.ado4077</a>."},"scopus_import":"1","publisher":"American Association for the Advancement of Science","status":"public","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"type":"journal_article","year":"2024","article_type":"letter_note","date_created":"2024-03-24T23:00:58Z","author":[{"full_name":"Navita, Navita","id":"6ebe278d-ba0b-11ee-8184-f34cdc671de4","orcid":"0000-0001-7408-8197","last_name":"Navita","first_name":"Navita"},{"id":"43C61214-F248-11E8-B48F-1D18A9856A87","full_name":"Ibáñez, Maria","last_name":"Ibáñez","first_name":"Maria","orcid":"0000-0001-5013-2843"}],"language":[{"iso":"eng"}],"intvolume":"       383","doi":"10.1126/science.ado4077","project":[{"_id":"9B8F7476-BA93-11EA-9121-9846C619BF3A","name":"HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery"}],"publication_status":"published","pmid":1,"issue":"6688","department":[{"_id":"MaIb"}],"_id":"15166","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","page":"1184","day":"14","publication":"Science","corr_author":"1"},{"day":"22","OA_place":"repository","publication":"Science","_id":"15251","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","department":[{"_id":"JiFr"}],"issue":"6689","pmid":1,"page":"eadj4591","language":[{"iso":"eng"}],"author":[{"first_name":"Wei","last_name":"Ying","full_name":"Ying, Wei"},{"last_name":"Wang","first_name":"Yaowei","full_name":"Wang, Yaowei"},{"last_name":"Wei","first_name":"Hong","full_name":"Wei, Hong"},{"full_name":"Luo, Yongming","first_name":"Yongming","last_name":"Luo"},{"last_name":"Ma","first_name":"Qian","full_name":"Ma, Qian"},{"full_name":"Zhu, Heyuan","last_name":"Zhu","first_name":"Heyuan"},{"first_name":"Hilde","last_name":"Janssens","full_name":"Janssens, Hilde"},{"full_name":"Vukašinović, Nemanja","last_name":"Vukašinović","first_name":"Nemanja"},{"first_name":"Miroslav","last_name":"Kvasnica","full_name":"Kvasnica, Miroslav"},{"full_name":"Winne, Johan M.","first_name":"Johan M.","last_name":"Winne"},{"full_name":"Gao, Yongxiang","last_name":"Gao","first_name":"Yongxiang"},{"id":"2DE75584-F248-11E8-B48F-1D18A9856A87","full_name":"Tan, Shutang","first_name":"Shutang","last_name":"Tan","orcid":"0000-0002-0471-8285"},{"last_name":"Friml","first_name":"Jiří","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří"},{"last_name":"Liu","first_name":"Xin","full_name":"Liu, Xin"},{"last_name":"Russinova","first_name":"Eugenia","full_name":"Russinova, Eugenia"},{"last_name":"Sun","first_name":"Linfeng","full_name":"Sun, Linfeng"}],"oa":1,"publication_status":"published","doi":"10.1126/science.adj4591","intvolume":"       383","year":"2024","date_created":"2024-03-31T22:01:12Z","article_type":"original","OA_type":"green","type":"journal_article","publication_identifier":{"eissn":["1095-9203"]},"status":"public","scopus_import":"1","abstract":[{"lang":"eng","text":"Brassinosteroids are steroidal phytohormones that regulate plant development and physiology, including adaptation to environmental stresses. Brassinosteroids are synthesized in the cell interior but bind receptors at the cell surface, necessitating a yet to be identified export mechanism. Here, we show that a member of the ATP-binding cassette (ABC) transporter superfamily, ABCB19, functions as a brassinosteroid exporter. We present its structure in both the substrate-unbound and the brassinosteroid-bound states. Bioactive brassinosteroids are potent activators of ABCB19 ATP hydrolysis activity, and transport assays showed that ABCB19 transports brassinosteroids. In Arabidopsis thaliana, ABCB19 and its close homolog, ABCB1, positively regulate brassinosteroid responses. Our results uncover an elusive export mechanism for bioactive brassinosteroids that is tightly coordinated with brassinosteroid signaling."}],"citation":{"ieee":"W. Ying <i>et al.</i>, “Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export,” <i>Science</i>, vol. 383, no. 6689. American Association for the Advancement of Science, p. eadj4591, 2024.","ama":"Ying W, Wang Y, Wei H, et al. Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export. <i>Science</i>. 2024;383(6689):eadj4591. doi:<a href=\"https://doi.org/10.1126/science.adj4591\">10.1126/science.adj4591</a>","apa":"Ying, W., Wang, Y., Wei, H., Luo, Y., Ma, Q., Zhu, H., … Sun, L. (2024). Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adj4591\">https://doi.org/10.1126/science.adj4591</a>","chicago":"Ying, Wei, Yaowei Wang, Hong Wei, Yongming Luo, Qian Ma, Heyuan Zhu, Hilde Janssens, et al. “Structure and Function of the Arabidopsis ABC Transporter ABCB19 in Brassinosteroid Export.” <i>Science</i>. American Association for the Advancement of Science, 2024. <a href=\"https://doi.org/10.1126/science.adj4591\">https://doi.org/10.1126/science.adj4591</a>.","mla":"Ying, Wei, et al. “Structure and Function of the Arabidopsis ABC Transporter ABCB19 in Brassinosteroid Export.” <i>Science</i>, vol. 383, no. 6689, American Association for the Advancement of Science, 2024, p. eadj4591, doi:<a href=\"https://doi.org/10.1126/science.adj4591\">10.1126/science.adj4591</a>.","short":"W. Ying, Y. Wang, H. Wei, Y. Luo, Q. Ma, H. Zhu, H. Janssens, N. Vukašinović, M. Kvasnica, J.M. Winne, Y. Gao, S. Tan, J. Friml, X. Liu, E. Russinova, L. Sun, Science 383 (2024) eadj4591.","ista":"Ying W, Wang Y, Wei H, Luo Y, Ma Q, Zhu H, Janssens H, Vukašinović N, Kvasnica M, Winne JM, Gao Y, Tan S, Friml J, Liu X, Russinova E, Sun L. 2024. Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export. Science. 383(6689), eadj4591."},"oa_version":"Submitted Version","publisher":"American Association for the Advancement of Science","main_file_link":[{"url":"http://hdl.handle.net/1854/LU-01HTMBK3P3PPNB73YFCMFXP3ZZ","open_access":"1"}],"external_id":{"pmid":["38513023"],"isi":["001252955200028"]},"date_updated":"2025-09-04T13:19:48Z","quality_controlled":"1","month":"03","volume":383,"title":"Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export","date_published":"2024-03-22T00:00:00Z","article_processing_charge":"No","acknowledgement":"We thank the Cryo-EM Center of the University of Science and Technology of China for the EM facility support, Y. Yin (Iowa State University, Ames, IA, USA) for providing the anti-BES1 antibody, Y. Gao and all other staff members for their technical support on cryo-EM data collection, S. Vanneste (VIB, Ghent University, Ghent, Belgium) for useful discussions, and M. De Cock for help in preparing the manuscript.\r\nThis work was supported by the National Natural Science Foundation of China (grants 31870732 and 32322041 to L.S., grant 31900885 to X.L., and grant 32321001 to L.S.); the Strategic Priority Research Program of the Chinese Academy of Sciences (grant XDB37020103 to L.S.); the Natural Science Foundation of Anhui Province (grant 2008085MC90 to X.L. and grant 2008085J15 to L.S.); Fundamental Research Funds for the Central Universities (grant WK9100000031 to L.S.); USTC Research Funds of the Double First-Class Initiative (grant YD9100002004 to L.S. and grant YD9100002020 to X.L.); Research Foundation-Flanders (grant G002121N to E.R. and postdoctoral fellowships 12R7822N and 12R7819N to N.V.); and Chinese Scholarship Council predoctoral fellowships (Y.W. and H.Z.). L.S. is supported by an Outstanding Young Scholar Award from the Qiu Shi Science and Technologies Foundation and a Young Scholar Award from the Cyrus Tang Foundation.","isi":1},{"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615865"}],"publisher":"AAAS","oa_version":"Submitted Version","abstract":[{"text":"Genomic DNA that resides in the nuclei of mammalian neurons can be as old as the organism itself. The life span of nuclear RNAs, which are critical for proper chromatin architecture and transcription regulation, has not been determined in adult tissues. In this work, we identified and characterized nuclear RNAs that do not turn over for at least 2 years in a subset of postnatally born cells in the mouse brain. These long-lived RNAs were stably retained in nuclei in a neural cell type–specific manner and were required for the maintenance of heterochromatin. Thus, the life span of neural cells may depend on both the molecular longevity of DNA for the storage of genetic information and also the extreme stability of RNA for the functional organization of chromatin.","lang":"eng"}],"citation":{"ista":"Zocher S, Mccloskey A, Karasinsky A, Schulte R, Friedrich U, Lesche M, Rund N, Gage FH, Hetzer M, Toda T. 2024. Lifelong persistence of nuclear RNAs in the mouse brain. Science. 384(6691), 53–59.","short":"S. Zocher, A. Mccloskey, A. Karasinsky, R. Schulte, U. Friedrich, M. Lesche, N. Rund, F.H. Gage, M. Hetzer, T. Toda, Science 384 (2024) 53–59.","mla":"Zocher, Sara, et al. “Lifelong Persistence of Nuclear RNAs in the Mouse Brain.” <i>Science</i>, vol. 384, no. 6691, AAAS, 2024, pp. 53–59, doi:<a href=\"https://doi.org/10.1126/science.adf3481\">10.1126/science.adf3481</a>.","chicago":"Zocher, Sara, Asako Mccloskey, Anne Karasinsky, Roberta Schulte, Ulrike Friedrich, Mathias Lesche, Nicole Rund, Fred H. Gage, Martin Hetzer, and Tomohisa Toda. “Lifelong Persistence of Nuclear RNAs in the Mouse Brain.” <i>Science</i>. AAAS, 2024. <a href=\"https://doi.org/10.1126/science.adf3481\">https://doi.org/10.1126/science.adf3481</a>.","apa":"Zocher, S., Mccloskey, A., Karasinsky, A., Schulte, R., Friedrich, U., Lesche, M., … Toda, T. (2024). Lifelong persistence of nuclear RNAs in the mouse brain. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.adf3481\">https://doi.org/10.1126/science.adf3481</a>","ama":"Zocher S, Mccloskey A, Karasinsky A, et al. Lifelong persistence of nuclear RNAs in the mouse brain. <i>Science</i>. 2024;384(6691):53-59. doi:<a href=\"https://doi.org/10.1126/science.adf3481\">10.1126/science.adf3481</a>","ieee":"S. Zocher <i>et al.</i>, “Lifelong persistence of nuclear RNAs in the mouse brain,” <i>Science</i>, vol. 384, no. 6691. AAAS, pp. 53–59, 2024."},"scopus_import":"1","status":"public","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"type":"journal_article","OA_type":"green","related_material":{"link":[{"description":"News on ISTA website","url":"https://ista.ac.at/en/news/nerve-cells-old-at-heart/","relation":"press_release"}]},"isi":1,"acknowledgement":"European Research Council: ERC-2018-STG, 804468 EAGER; European Research Council: ERC-2023-COG, 101125034 NEUTIME; Deutsche Forschungsgemeinschaft: TO1347/4-1; Boehringer Ingelheim Stiftung; Deutsches Zentrum für Neurodegenerative Erkrankungen","article_processing_charge":"No","date_published":"2024-04-04T00:00:00Z","title":"Lifelong persistence of nuclear RNAs in the mouse brain","volume":384,"month":"04","quality_controlled":"1","date_updated":"2025-09-04T13:39:58Z","external_id":{"pmid":["38574132"],"isi":["001253335100031"]},"page":"53-59","pmid":1,"issue":"6691","department":[{"_id":"MaHe"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","_id":"15316","publication":"Science","corr_author":"1","OA_place":"repository","day":"04","article_type":"original","date_created":"2024-04-14T22:01:01Z","year":"2024","intvolume":"       384","doi":"10.1126/science.adf3481","publication_status":"published","oa":1,"author":[{"full_name":"Zocher, Sara","last_name":"Zocher","first_name":"Sara"},{"full_name":"Mccloskey, Asako","first_name":"Asako","last_name":"Mccloskey"},{"full_name":"Karasinsky, Anne","first_name":"Anne","last_name":"Karasinsky"},{"last_name":"Schulte","first_name":"Roberta","full_name":"Schulte, Roberta"},{"full_name":"Friedrich, Ulrike","last_name":"Friedrich","first_name":"Ulrike"},{"full_name":"Lesche, Mathias","first_name":"Mathias","last_name":"Lesche"},{"full_name":"Rund, Nicole","last_name":"Rund","first_name":"Nicole"},{"first_name":"Fred H.","last_name":"Gage","full_name":"Gage, Fred H."},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","full_name":"Hetzer, Martin W","first_name":"Martin W","last_name":"Hetzer","orcid":"0000-0002-2111-992X"},{"full_name":"Toda, Tomohisa","first_name":"Tomohisa","last_name":"Toda"}],"language":[{"iso":"eng"}]},{"status":"public","type":"journal_article","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"OA_type":"green","main_file_link":[{"open_access":"1","url":"https://figshare.com/articles/journal_contribution/Strong_damped_Lyman-_absorption_in_young_star-forming_galaxies_at_redshifts_9_to_11/26069122?file=47174584"}],"publisher":"AAAS","citation":{"short":"K.E. Heintz, D. Watson, G. Brammer, S. Vejlgaard, A. Hutter, V.B. Strait, J.J. Matthee, P.A. Oesch, P. Jakobsson, N.R. Tanvir, P. Laursen, R.P. Naidu, C.A. Mason, M. Killi, I. Jung, T.Y.Y. Hsiao, U. Abdurro’Uf, D. Coe, P.A. Haro, S.L. Finkelstein, S. Toft, Science 384 (2024) 890–894.","ista":"Heintz KE, Watson D, Brammer G, Vejlgaard S, Hutter A, Strait VB, Matthee JJ, Oesch PA, Jakobsson P, Tanvir NR, Laursen P, Naidu RP, Mason CA, Killi M, Jung I, Hsiao TYY, Abdurro’Uf U, Coe D, Haro PA, Finkelstein SL, Toft S. 2024. Strong damped Lyman-a absorption in young star-forming galaxies at redshifts 9 to 11. Science. 384(6698), 890–894.","mla":"Heintz, Kasper E., et al. “Strong Damped Lyman-a Absorption in Young Star-Forming Galaxies at Redshifts 9 to 11.” <i>Science</i>, vol. 384, no. 6698, AAAS, 2024, pp. 890–94, doi:<a href=\"https://doi.org/10.1126/science.adj0343\">10.1126/science.adj0343</a>.","chicago":"Heintz, Kasper E., Darach Watson, Gabriel Brammer, Simone Vejlgaard, Anne Hutter, Victoria B. Strait, Jorryt J Matthee, et al. “Strong Damped Lyman-a Absorption in Young Star-Forming Galaxies at Redshifts 9 to 11.” <i>Science</i>. AAAS, 2024. <a href=\"https://doi.org/10.1126/science.adj0343\">https://doi.org/10.1126/science.adj0343</a>.","apa":"Heintz, K. E., Watson, D., Brammer, G., Vejlgaard, S., Hutter, A., Strait, V. B., … Toft, S. (2024). Strong damped Lyman-a absorption in young star-forming galaxies at redshifts 9 to 11. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.adj0343\">https://doi.org/10.1126/science.adj0343</a>","ama":"Heintz KE, Watson D, Brammer G, et al. Strong damped Lyman-a absorption in young star-forming galaxies at redshifts 9 to 11. <i>Science</i>. 2024;384(6698):890-894. doi:<a href=\"https://doi.org/10.1126/science.adj0343\">10.1126/science.adj0343</a>","ieee":"K. E. Heintz <i>et al.</i>, “Strong damped Lyman-a absorption in young star-forming galaxies at redshifts 9 to 11,” <i>Science</i>, vol. 384, no. 6698. AAAS, pp. 890–894, 2024."},"scopus_import":"1","abstract":[{"text":"Primordial neutral atomic gas, mostly composed of hydrogen, is the raw material for star formation in galaxies. However, there are few direct constraints on the amount of neutral atomic hydrogen (H i) in galaxies at early cosmic times. We analyzed James Webb Space Telescope (JWST) near-infrared spectroscopy of distant galaxies, at redshifts ≳8. From a sample of 12 galaxies, we identified three that show strong damped Lyman-α absorption due to H i in their local surroundings. The galaxies are located at spectroscopic redshifts of 8.8, 10.2, and 11.4, corresponding to 400 to 600 million years after the Big Bang. They have H i column densities ≳1022 cm−2, which is an order of magnitude higher than expected for a fully neutral intergalactic medium, and constitute a gas-rich population of young star-forming galaxies.","lang":"eng"}],"oa_version":"Submitted Version","month":"05","date_updated":"2025-09-08T07:43:13Z","quality_controlled":"1","external_id":{"pmid":["38781391"],"isi":["001230029500001"]},"date_published":"2024-05-24T00:00:00Z","article_processing_charge":"No","isi":1,"acknowledgement":"K.E.H. acknowledges support from Carlsberg Foundation Reintegration Fellowship grant CF21-0103. A.H. acknowledges support from the VILLUM FONDEN under grant 37459. C.A.M. acknowledges support from the VILLUM FONDEN under grant 37459 and the Carlsberg Foundation under grant CF22-1322. N.R.T. was funded through Science and Technology Facilities Council (STFC) consolidated grant ST/W000857/1. R.P.N. acknowledges funding from JWST programs GO-1933 and GO-2279. R.P.N. was supported by the NASA Hubble Fellowship grant HST-HF2-51515.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy under NASA contract NAS5-26555. P.A.O. received funding from the Swiss State Secretariat for Education, Research, and Innovation (SERI) under contract number MB22.00072 and from the Swiss National Science Foundation (SNSF) through project grant 200020_207349.","title":"Strong damped Lyman-a absorption in young star-forming galaxies at redshifts 9 to 11","volume":384,"publication":"Science","OA_place":"repository","day":"24","page":"890-894","pmid":1,"_id":"17090","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","issue":"6698","department":[{"_id":"JoMa"}],"intvolume":"       384","publication_status":"published","oa":1,"doi":"10.1126/science.adj0343","language":[{"iso":"eng"}],"author":[{"full_name":"Heintz, Kasper E.","first_name":"Kasper E.","last_name":"Heintz"},{"full_name":"Watson, Darach","last_name":"Watson","first_name":"Darach"},{"full_name":"Brammer, Gabriel","last_name":"Brammer","first_name":"Gabriel"},{"full_name":"Vejlgaard, Simone","first_name":"Simone","last_name":"Vejlgaard"},{"full_name":"Hutter, Anne","first_name":"Anne","last_name":"Hutter"},{"full_name":"Strait, Victoria B.","first_name":"Victoria B.","last_name":"Strait"},{"full_name":"Matthee, Jorryt J","id":"7439a258-f3c0-11ec-9501-9df22fe06720","orcid":"0000-0003-2871-127X","first_name":"Jorryt J","last_name":"Matthee"},{"first_name":"Pascal A.","last_name":"Oesch","full_name":"Oesch, Pascal A."},{"first_name":"Páll","last_name":"Jakobsson","full_name":"Jakobsson, Páll"},{"last_name":"Tanvir","first_name":"Nial R.","full_name":"Tanvir, Nial R."},{"last_name":"Laursen","first_name":"Peter","full_name":"Laursen, Peter"},{"full_name":"Naidu, Rohan P.","first_name":"Rohan P.","last_name":"Naidu"},{"first_name":"Charlotte A.","last_name":"Mason","full_name":"Mason, Charlotte A."},{"first_name":"Meghana","last_name":"Killi","full_name":"Killi, Meghana"},{"last_name":"Jung","first_name":"Intae","full_name":"Jung, Intae"},{"full_name":"Hsiao, Tiger Yu Yang","last_name":"Hsiao","first_name":"Tiger Yu Yang"},{"full_name":"Abdurro’Uf, Unknown","last_name":"Abdurro’Uf","first_name":"Unknown"},{"full_name":"Coe, Dan","first_name":"Dan","last_name":"Coe"},{"full_name":"Haro, Pablo Arrabal","last_name":"Haro","first_name":"Pablo Arrabal"},{"full_name":"Finkelstein, Steven L.","last_name":"Finkelstein","first_name":"Steven L."},{"full_name":"Toft, Sune","first_name":"Sune","last_name":"Toft"}],"article_type":"original","date_created":"2024-06-02T22:00:56Z","year":"2024"},{"page":"860-861","issue":"6698","department":[{"_id":"GaNo"}],"_id":"17091","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","pmid":1,"corr_author":"1","publication":"Science","day":"24","date_created":"2024-06-02T22:00:57Z","article_type":"letter_note","year":"2024","doi":"10.1126/science.adp4663","publication_status":"published","intvolume":"       384","author":[{"full_name":"Novarino, Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","first_name":"Gaia","last_name":"Novarino"},{"full_name":"Bock, Christoph","first_name":"Christoph","last_name":"Bock"}],"language":[{"iso":"eng"}],"publisher":"AAAS","oa_version":"None","scopus_import":"1","abstract":[{"text":"DNA sequences are connected to genes and functions in the developing and adult brain","lang":"eng"}],"citation":{"ama":"Novarino G, Bock C. Mapping the brain’s gene-regulatory maze. <i>Science</i>. 2024;384(6698):860-861. doi:<a href=\"https://doi.org/10.1126/science.adp4663\">10.1126/science.adp4663</a>","ieee":"G. Novarino and C. Bock, “Mapping the brain’s gene-regulatory maze,” <i>Science</i>, vol. 384, no. 6698. AAAS, pp. 860–861, 2024.","mla":"Novarino, Gaia, and Christoph Bock. “Mapping the Brain’s Gene-Regulatory Maze.” <i>Science</i>, vol. 384, no. 6698, AAAS, 2024, pp. 860–61, doi:<a href=\"https://doi.org/10.1126/science.adp4663\">10.1126/science.adp4663</a>.","short":"G. Novarino, C. Bock, Science 384 (2024) 860–861.","ista":"Novarino G, Bock C. 2024. Mapping the brain’s gene-regulatory maze. Science. 384(6698), 860–861.","apa":"Novarino, G., &#38; Bock, C. (2024). Mapping the brain’s gene-regulatory maze. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.adp4663\">https://doi.org/10.1126/science.adp4663</a>","chicago":"Novarino, Gaia, and Christoph Bock. “Mapping the Brain’s Gene-Regulatory Maze.” <i>Science</i>. AAAS, 2024. <a href=\"https://doi.org/10.1126/science.adp4663\">https://doi.org/10.1126/science.adp4663</a>."},"publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"type":"journal_article","status":"public","title":"Mapping the brain’s gene-regulatory maze","isi":1,"date_published":"2024-05-24T00:00:00Z","article_processing_charge":"No","volume":384,"month":"05","external_id":{"isi":["001230076500007"],"pmid":["38781359"]},"quality_controlled":"1","date_updated":"2025-09-08T07:40:10Z"},{"year":"2024","article_type":"original","date_created":"2024-06-04T06:41:26Z","language":[{"iso":"eng"}],"author":[{"full_name":"Steens, Jurre A.","first_name":"Jurre A.","last_name":"Steens"},{"first_name":"Jack Peter Kelly","last_name":"Bravo","orcid":"0000-0003-0456-0753","id":"96aecfa5-8931-11ee-af30-aa6a5d6eee0e","full_name":"Bravo, Jack Peter Kelly"},{"last_name":"Salazar","first_name":"Carl Raymund P.","full_name":"Salazar, Carl Raymund P."},{"full_name":"Yildiz, Caglar","last_name":"Yildiz","first_name":"Caglar"},{"first_name":"Afonso M.","last_name":"Amieiro","full_name":"Amieiro, Afonso M."},{"full_name":"Köstlbacher, Stephan","first_name":"Stephan","last_name":"Köstlbacher"},{"last_name":"Prinsen","first_name":"Stijn H.P.","full_name":"Prinsen, Stijn H.P."},{"full_name":"Patinios, Constantinos","last_name":"Patinios","first_name":"Constantinos"},{"full_name":"Bardis, Andreas","first_name":"Andreas","last_name":"Bardis"},{"full_name":"Barendregt, Arjan","last_name":"Barendregt","first_name":"Arjan"},{"full_name":"Scheltema, Richard A.","first_name":"Richard A.","last_name":"Scheltema"},{"full_name":"Ettema, Thijs J.G.","first_name":"Thijs J.G.","last_name":"Ettema"},{"full_name":"van der Oost, John","last_name":"van der Oost","first_name":"John"},{"full_name":"Taylor, David W.","last_name":"Taylor","first_name":"David W."},{"first_name":"Raymond H.J.","last_name":"Staals","full_name":"Staals, Raymond H.J."}],"intvolume":"       383","publication_status":"published","extern":"1","oa":1,"doi":"10.1126/science.adk0378","pmid":1,"_id":"17112","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"6682","page":"512-519","day":"01","publication":"Science","OA_place":"repository","volume":383,"article_processing_charge":"No","date_published":"2024-02-01T00:00:00Z","acknowledgement":"We thank R. Fregoso Ocampo for assistance with negative-stain EM imaging. This work was funded by Dutch Research Council (NWO) VIDI grant VI.Vidi.203.074 (R.H.J.S.), NWO Spinoza grant SPI 93-537 (J.v.d.O.), European Research Council (ERC) Advanced grant ERC-AdG-834279 (J.v.d.O.), ERC CoG grant 817834 (T.J.G.E.), NWO VICI grant VI.C.192.016 (T.J.G.E.), Volkswagen Foundation grant 96725 (T.J.G.E.), National Institute of General Medical Sciences of the National Institutes of Health grant R35GM138348 (D.W.T.), Welch Foundation research grant F-1938 (D.W.T.), a Robert J. Kleberg, Jr. And Helen C. Kleberg Foundation medical research grant (D.W.T.), and American Cancer Society Research Scholar grant RSG-21-050-01-DMC (D.W.T.).","title":"Type III-B CRISPR-Cas cascade of proteolytic cleavages","date_updated":"2025-09-24T08:31:45Z","quality_controlled":"1","external_id":{"pmid":["38301007"]},"month":"02","abstract":[{"lang":"eng","text":"The generation of cyclic oligoadenylates and subsequent allosteric activation of proteins that carry sensory domains is a distinctive feature of type III CRISPR-Cas systems. In this work, we characterize a set of associated genes of a type III-B system from Haliangium ochraceum that contains two caspase-like proteases, SAVED-CHAT and PCaspase (prokaryotic caspase), co-opted from a cyclic oligonucleotide–based antiphage signaling system (CBASS). Cyclic tri–adenosine monophosphate (AMP)–induced oligomerization of SAVED-CHAT activates proteolytic activity of the CHAT domains, which specifically cleave and activate PCaspase. Subsequently, activated PCaspase cleaves a multitude of proteins, which results in a strong interference phenotype in vivo in Escherichia coli. Taken together, our findings reveal how a CRISPR-Cas–based detection of a target RNA triggers a cascade of caspase-associated proteolytic activities."}],"citation":{"ieee":"J. A. Steens <i>et al.</i>, “Type III-B CRISPR-Cas cascade of proteolytic cleavages,” <i>Science</i>, vol. 383, no. 6682. American Association for the Advancement of Science, pp. 512–519, 2024.","ama":"Steens JA, Bravo JPK, Salazar CRP, et al. Type III-B CRISPR-Cas cascade of proteolytic cleavages. <i>Science</i>. 2024;383(6682):512-519. doi:<a href=\"https://doi.org/10.1126/science.adk0378\">10.1126/science.adk0378</a>","chicago":"Steens, Jurre A., Jack Peter Kelly Bravo, Carl Raymund P. Salazar, Caglar Yildiz, Afonso M. Amieiro, Stephan Köstlbacher, Stijn H.P. Prinsen, et al. “Type III-B CRISPR-Cas Cascade of Proteolytic Cleavages.” <i>Science</i>. American Association for the Advancement of Science, 2024. <a href=\"https://doi.org/10.1126/science.adk0378\">https://doi.org/10.1126/science.adk0378</a>.","apa":"Steens, J. A., Bravo, J. P. K., Salazar, C. R. P., Yildiz, C., Amieiro, A. M., Köstlbacher, S., … Staals, R. H. J. (2024). Type III-B CRISPR-Cas cascade of proteolytic cleavages. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adk0378\">https://doi.org/10.1126/science.adk0378</a>","ista":"Steens JA, Bravo JPK, Salazar CRP, Yildiz C, Amieiro AM, Köstlbacher S, Prinsen SHP, Patinios C, Bardis A, Barendregt A, Scheltema RA, Ettema TJG, van der Oost J, Taylor DW, Staals RHJ. 2024. Type III-B CRISPR-Cas cascade of proteolytic cleavages. Science. 383(6682), 512–519.","short":"J.A. Steens, J.P.K. Bravo, C.R.P. Salazar, C. Yildiz, A.M. Amieiro, S. Köstlbacher, S.H.P. Prinsen, C. Patinios, A. Bardis, A. Barendregt, R.A. Scheltema, T.J.G. Ettema, J. van der Oost, D.W. Taylor, R.H.J. Staals, Science 383 (2024) 512–519.","mla":"Steens, Jurre A., et al. “Type III-B CRISPR-Cas Cascade of Proteolytic Cleavages.” <i>Science</i>, vol. 383, no. 6682, American Association for the Advancement of Science, 2024, pp. 512–19, doi:<a href=\"https://doi.org/10.1126/science.adk0378\">10.1126/science.adk0378</a>."},"scopus_import":"1","oa_version":"Preprint","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2023.06.23.546230"}],"publisher":"American Association for the Advancement of Science","OA_type":"green","status":"public","type":"journal_article","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]}},{"isi":1,"acknowledgement":"We are grateful to the members of the Hiiragi laboratory for discussions and comments on the manuscript: R. Bloehs, S. Friese, S. Hozeifi, L. Pérez, and W. Schwarzer for their technical support; V. Janssen for establishing the PAB protocol; members of the Tsukiyama group for the animal care with monkeys, in particular H. Tsuchiya and M. Nakaya; Unité Commune d’Expérimentation Animale (UCEA, Jouy-en-Josas, France) for the animal care with rabbits; the EMBL electronic and mechanical workshops and the EMBL animal facility for their support; We thank Luxendo for the close collaboration in developing the light-sheet microscopy for mammalian embryos.\r\nFunding: This work was funded by the following: EMBL Interdisciplinary Postdoc Program (EIPOD) under Marie Sklodowska Curie Actions COFUND III RTD (to D.F.); JSPS Overseas Research Fellowship (to T.I.); Field of excellence “Complexity of life in basic research and innovation” of the University of Graz (to B.C.M.); European Research Council, ERC Advanced Grant “SelforganisingEmbryo”, grant agreement 742732; ERC Advanced Grant “COORDINATION” grant agreement 101055287 (to T.H.); Stichting LSH-TKI, grant LSHM21020 (to T.H.) JSPS KAKENHI grants JP21H05038 and JP22H05166 (to T.H.)","article_processing_charge":"No","date_published":"2024-10-11T00:00:00Z","title":"Temporal variability and cell mechanics control robustness in mammalian embryogenesis","volume":386,"month":"10","date_updated":"2025-09-08T14:22:13Z","quality_controlled":"1","external_id":{"isi":["001422132300018"],"pmid":["39388574"]},"main_file_link":[{"url":"https://hal.inrae.fr/hal-04447081v1/file/2023.01.24.525420.full.pdf","open_access":"1"}],"publisher":"AAAS","oa_version":"Submitted Version","article_number":"eadh1145","citation":{"ieee":"D. Fabrèges <i>et al.</i>, “Temporal variability and cell mechanics control robustness in mammalian embryogenesis,” <i>Science</i>, vol. 386, no. 6718. AAAS, 2024.","ama":"Fabrèges D, Corominas-Murtra B, Moghe P, et al. Temporal variability and cell mechanics control robustness in mammalian embryogenesis. <i>Science</i>. 2024;386(6718). doi:<a href=\"https://doi.org/10.1126/science.adh1145\">10.1126/science.adh1145</a>","chicago":"Fabrèges, Dimitri, Bernat Corominas-Murtra, Prachiti Moghe, Alison Kickuth, Takafumi Ichikawa, Chizuru Iwatani, Tomoyuki Tsukiyama, et al. “Temporal Variability and Cell Mechanics Control Robustness in Mammalian Embryogenesis.” <i>Science</i>. AAAS, 2024. <a href=\"https://doi.org/10.1126/science.adh1145\">https://doi.org/10.1126/science.adh1145</a>.","apa":"Fabrèges, D., Corominas-Murtra, B., Moghe, P., Kickuth, A., Ichikawa, T., Iwatani, C., … Hiiragi, T. (2024). Temporal variability and cell mechanics control robustness in mammalian embryogenesis. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.adh1145\">https://doi.org/10.1126/science.adh1145</a>","short":"D. Fabrèges, B. Corominas-Murtra, P. Moghe, A. Kickuth, T. Ichikawa, C. Iwatani, T. Tsukiyama, N. Daniel, J. Gering, A. Stokkermans, A. Wolny, A. Kreshuk, V. Duranthon, V. Uhlman, E.B. Hannezo, T. Hiiragi, Science 386 (2024).","ista":"Fabrèges D, Corominas-Murtra B, Moghe P, Kickuth A, Ichikawa T, Iwatani C, Tsukiyama T, Daniel N, Gering J, Stokkermans A, Wolny A, Kreshuk A, Duranthon V, Uhlman V, Hannezo EB, Hiiragi T. 2024. Temporal variability and cell mechanics control robustness in mammalian embryogenesis. Science. 386(6718), eadh1145.","mla":"Fabrèges, Dimitri, et al. “Temporal Variability and Cell Mechanics Control Robustness in Mammalian Embryogenesis.” <i>Science</i>, vol. 386, no. 6718, eadh1145, AAAS, 2024, doi:<a href=\"https://doi.org/10.1126/science.adh1145\">10.1126/science.adh1145</a>."},"abstract":[{"lang":"eng","text":"How living systems achieve precision in form and function despite their intrinsic stochasticity is a fundamental yet ongoing question in biology. We generated morphomaps of preimplantation embryogenesis in mouse, rabbit, and monkey embryos, and these morphomaps revealed that although blastomere divisions desynchronized passively, 8-cell embryos converged toward robust three-dimensional shapes. Using topological analysis and genetic perturbations, we found that embryos progressively changed their cellular connectivity to a preferred topology, which could be predicted by a physical model in which actomyosin contractility and noise facilitate topological transitions, lowering surface energy. This mechanism favored regular embryo packing and promoted a higher number of inner cells in the 16-cell embryo. Synchronized division reduced embryo packing and generated substantially more misallocated cells and fewer inner-cell–mass cells. These findings suggest that stochasticity in division timing contributes to robust patterning."}],"scopus_import":"1","status":"public","publication_identifier":{"eissn":["1095-9203"]},"type":"journal_article","OA_type":"green","article_type":"original","date_created":"2024-10-20T22:02:06Z","year":"2024","intvolume":"       386","doi":"10.1126/science.adh1145","oa":1,"publication_status":"published","author":[{"last_name":"Fabrèges","first_name":"Dimitri","full_name":"Fabrèges, Dimitri"},{"orcid":"0000-0001-9806-5643","last_name":"Corominas-Murtra","first_name":"Bernat","full_name":"Corominas-Murtra, Bernat","id":"43BE2298-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Moghe","first_name":"Prachiti","full_name":"Moghe, Prachiti"},{"first_name":"Alison","last_name":"Kickuth","full_name":"Kickuth, Alison"},{"full_name":"Ichikawa, Takafumi","last_name":"Ichikawa","first_name":"Takafumi"},{"last_name":"Iwatani","first_name":"Chizuru","full_name":"Iwatani, Chizuru"},{"first_name":"Tomoyuki","last_name":"Tsukiyama","full_name":"Tsukiyama, Tomoyuki"},{"first_name":"Nathalie","last_name":"Daniel","full_name":"Daniel, Nathalie"},{"full_name":"Gering, Julie","last_name":"Gering","first_name":"Julie"},{"first_name":"Anniek","last_name":"Stokkermans","full_name":"Stokkermans, Anniek"},{"full_name":"Wolny, Adrian","last_name":"Wolny","first_name":"Adrian"},{"first_name":"Anna","last_name":"Kreshuk","full_name":"Kreshuk, Anna"},{"first_name":"Véronique","last_name":"Duranthon","full_name":"Duranthon, Véronique"},{"full_name":"Uhlman, Virginie","last_name":"Uhlman","first_name":"Virginie"},{"full_name":"Hannezo, Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6005-1561","first_name":"Edouard B","last_name":"Hannezo"},{"last_name":"Hiiragi","first_name":"Takashi","full_name":"Hiiragi, Takashi"}],"language":[{"iso":"eng"}],"pmid":1,"department":[{"_id":"EdHa"}],"issue":"6718","_id":"18446","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication":"Science","corr_author":"1","OA_place":"repository","day":"11"},{"OA_place":"repository","corr_author":"1","publication":"Science","day":"05","page":"114-119","department":[{"_id":"NiBa"},{"_id":"GradSch"}],"issue":"6678","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","_id":"14796","pmid":1,"doi":"10.1126/science.adi2982","publication_status":"published","oa":1,"intvolume":"       383","author":[{"full_name":"Stankowski, Sean","id":"43161670-5719-11EA-8025-FABC3DDC885E","last_name":"Stankowski","first_name":"Sean"},{"last_name":"Zagrodzka","first_name":"Zuzanna B.","full_name":"Zagrodzka, Zuzanna B."},{"last_name":"Garlovsky","first_name":"Martin D.","full_name":"Garlovsky, Martin D."},{"first_name":"Arka","last_name":"Pal","orcid":"0000-0002-4530-8469","id":"6AAB2240-CA9A-11E9-9C1A-D9D1E5697425","full_name":"Pal, Arka"},{"full_name":"Shipilina, Daria","id":"428A94B0-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-1145-9226","last_name":"Shipilina","first_name":"Daria"},{"last_name":"Garcia Castillo","first_name":"Diego Fernando","id":"ae681a14-dc74-11ea-a0a7-c6ef18161701","full_name":"Garcia Castillo, Diego Fernando"},{"id":"d6ab5470-2fb3-11ed-8633-986a9b84edac","full_name":"Lifchitz, Hila","last_name":"Lifchitz","first_name":"Hila"},{"full_name":"Le Moan, Alan","last_name":"Le Moan","first_name":"Alan"},{"full_name":"Leder, Erica","first_name":"Erica","last_name":"Leder"},{"full_name":"Reeve, James","first_name":"James","last_name":"Reeve"},{"full_name":"Johannesson, Kerstin","first_name":"Kerstin","last_name":"Johannesson"},{"last_name":"Westram","first_name":"Anja M","orcid":"0000-0003-1050-4969","id":"3C147470-F248-11E8-B48F-1D18A9856A87","full_name":"Westram, Anja M"},{"full_name":"Butlin, Roger K.","first_name":"Roger K.","last_name":"Butlin"}],"language":[{"iso":"eng"}],"date_created":"2024-01-14T23:00:56Z","article_type":"original","year":"2024","publication_identifier":{"eissn":["1095-9203"]},"type":"journal_article","status":"public","OA_type":"green","related_material":{"link":[{"relation":"press_release","url":"https://ista.ac.at/en/news/the-snail-or-the-egg/","description":"News on ISTA Website"}],"record":[{"id":"14812","relation":"research_data","status":"public"},{"relation":"dissertation_contains","id":"20694","status":"public"}]},"publisher":"American Association for the Advancement of Science","main_file_link":[{"open_access":"1","url":"https://figshare.com/articles/journal_contribution/The_genetic_basis_of_a_recent_transition_to_live-bearing_in_marine_snails/26356054?file=47868241"}],"oa_version":"Submitted Version","scopus_import":"1","citation":{"ieee":"S. Stankowski <i>et al.</i>, “The genetic basis of a recent transition to live-bearing in marine snails,” <i>Science</i>, vol. 383, no. 6678. American Association for the Advancement of Science, pp. 114–119, 2024.","ama":"Stankowski S, Zagrodzka ZB, Garlovsky MD, et al. The genetic basis of a recent transition to live-bearing in marine snails. <i>Science</i>. 2024;383(6678):114-119. doi:<a href=\"https://doi.org/10.1126/science.adi2982\">10.1126/science.adi2982</a>","chicago":"Stankowski, Sean, Zuzanna B. Zagrodzka, Martin D. Garlovsky, Arka Pal, Daria Shipilina, Diego Fernando Garcia Castillo, Hila Lifchitz, et al. “The Genetic Basis of a Recent Transition to Live-Bearing in Marine Snails.” <i>Science</i>. American Association for the Advancement of Science, 2024. <a href=\"https://doi.org/10.1126/science.adi2982\">https://doi.org/10.1126/science.adi2982</a>.","apa":"Stankowski, S., Zagrodzka, Z. B., Garlovsky, M. D., Pal, A., Shipilina, D., Garcia Castillo, D. F., … Butlin, R. K. (2024). The genetic basis of a recent transition to live-bearing in marine snails. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adi2982\">https://doi.org/10.1126/science.adi2982</a>","short":"S. Stankowski, Z.B. Zagrodzka, M.D. Garlovsky, A. Pal, D. Shipilina, D.F. Garcia Castillo, H. Lifchitz, A. Le Moan, E. Leder, J. Reeve, K. Johannesson, A.M. Westram, R.K. Butlin, Science 383 (2024) 114–119.","ista":"Stankowski S, Zagrodzka ZB, Garlovsky MD, Pal A, Shipilina D, Garcia Castillo DF, Lifchitz H, Le Moan A, Leder E, Reeve J, Johannesson K, Westram AM, Butlin RK. 2024. The genetic basis of a recent transition to live-bearing in marine snails. Science. 383(6678), 114–119.","mla":"Stankowski, Sean, et al. “The Genetic Basis of a Recent Transition to Live-Bearing in Marine Snails.” <i>Science</i>, vol. 383, no. 6678, American Association for the Advancement of Science, 2024, pp. 114–19, doi:<a href=\"https://doi.org/10.1126/science.adi2982\">10.1126/science.adi2982</a>."},"abstract":[{"text":"Key innovations are fundamental to biological diversification, but their genetic basis is poorly understood. A recent transition from egg-laying to live-bearing in marine snails (Littorina spp.) provides the opportunity to study the genetic architecture of an innovation that has evolved repeatedly across animals. Individuals do not cluster by reproductive mode in a genome-wide phylogeny, but local genealogical analysis revealed numerous small genomic regions where all live-bearers carry the same core haplotype. Candidate regions show evidence for live-bearer–specific positive selection and are enriched for genes that are differentially expressed between egg-laying and live-bearing reproductive systems. Ages of selective sweeps suggest that live-bearer–specific alleles accumulated over more than 200,000 generations. Our results suggest that new functions evolve through the recruitment of many alleles rather than in a single evolutionary step.","lang":"eng"}],"month":"01","external_id":{"isi":["001138156400003"],"pmid":["38175895"]},"date_updated":"2026-08-07T22:30:40Z","quality_controlled":"1","title":"The genetic basis of a recent transition to live-bearing in marine snails","isi":1,"acknowledgement":"We thank J. Galindo, M. Montaño-Rendón, N. Mikhailova, A. Blakeslee, E. Arnason, and P. Kemppainen for providing samples; R. Turney, G. Sotelo, J. Larsson, T. Broquet, and S. Loisel for help collecting samples; Science Animated for providing the snail cartoons shown in Fig. 1; M. Dunning for help in developing bioinformatic pipelines; R. Faria, H. Morales, and V. Sousa for advice; and M. Hahn, J. Slate, M. Ravinet, J. Raeymaekers, A. Comeault, and N. Barton for feedback on a draft manuscript.\r\nThis work was supported by the Natural Environment Research Council (grant NE/P001610/1 to R.K.B.), the European Research Council (grant ERC-2015-AdG693030-BARRIERS to R.K.B.), the Norwegian Research Council (RCN Project 315287 to A.M.W.), and the Swedish Research Council (grant 2020-05385 to E.L.).","article_processing_charge":"No","date_published":"2024-01-05T00:00:00Z","volume":383},{"day":"18","corr_author":"1","publication":"Science","_id":"13106","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ec_funded":1,"department":[{"_id":"JoFi"}],"issue":"6646","pmid":1,"page":"718-721","language":[{"iso":"eng"}],"author":[{"orcid":"0000-0001-6264-2162","last_name":"Sahu","first_name":"Rishabh","full_name":"Sahu, Rishabh","id":"47D26E34-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0003-4345-4267","last_name":"Qiu","first_name":"Liu","full_name":"Qiu, Liu","id":"45e99c0d-1eb1-11eb-9b96-ed8ab2983cac"},{"last_name":"Hease","first_name":"William J","orcid":"0000-0001-9868-2166","id":"29705398-F248-11E8-B48F-1D18A9856A87","full_name":"Hease, William J"},{"full_name":"Arnold, Georg M","id":"3770C838-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1397-7876","last_name":"Arnold","first_name":"Georg M"},{"last_name":"Minoguchi","first_name":"Y.","full_name":"Minoguchi, Y."},{"last_name":"Rabl","first_name":"P.","full_name":"Rabl, P."},{"id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","full_name":"Fink, Johannes M","last_name":"Fink","first_name":"Johannes M","orcid":"0000-0001-8112-028X"}],"publication_status":"published","oa":1,"doi":"10.1126/science.adg3812","project":[{"call_identifier":"H2020","name":"A Fiber Optic Transceiver for Superconducting Qubits","grant_number":"758053","_id":"26336814-B435-11E9-9278-68D0E5697425"},{"name":"Quantum Local Area Networks with Superconducting Qubits","call_identifier":"H2020","grant_number":"899354","_id":"9B868D20-BA93-11EA-9121-9846C619BF3A"},{"grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020"},{"_id":"237CBA6C-32DE-11EA-91FC-C7463DDC885E","grant_number":"862644","name":"Quantum readout techniques and technologies","call_identifier":"H2020"},{"_id":"2671EB66-B435-11E9-9278-68D0E5697425","name":"Coherent on-chip conversion of superconducting qubit signals from microwaves to optical frequencies"},{"grant_number":"F07105","_id":"bdb108fd-d553-11ed-ba76-83dc74a9864f","name":"QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration of Superconducting Quantum Circuits"}],"intvolume":"       380","year":"2023","date_created":"2023-05-31T11:39:24Z","article_type":"original","related_material":{"link":[{"relation":"press_release","description":"News on ISTA Website","url":"https://ista.ac.at/en/news/wiring-up-quantum-circuits-with-light/"}],"record":[{"id":"13122","relation":"research_data","status":"public"}]},"type":"journal_article","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"status":"public","citation":{"chicago":"Sahu, Rishabh, Liu Qiu, William J Hease, Georg M Arnold, Y. Minoguchi, P. Rabl, and Johannes M Fink. “Entangling Microwaves with Light.” <i>Science</i>. American Association for the Advancement of Science, 2023. <a href=\"https://doi.org/10.1126/science.adg3812\">https://doi.org/10.1126/science.adg3812</a>.","apa":"Sahu, R., Qiu, L., Hease, W. J., Arnold, G. M., Minoguchi, Y., Rabl, P., &#38; Fink, J. M. (2023). Entangling microwaves with light. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adg3812\">https://doi.org/10.1126/science.adg3812</a>","short":"R. Sahu, L. Qiu, W.J. Hease, G.M. Arnold, Y. Minoguchi, P. Rabl, J.M. Fink, Science 380 (2023) 718–721.","ista":"Sahu R, Qiu L, Hease WJ, Arnold GM, Minoguchi Y, Rabl P, Fink JM. 2023. Entangling microwaves with light. Science. 380(6646), 718–721.","mla":"Sahu, Rishabh, et al. “Entangling Microwaves with Light.” <i>Science</i>, vol. 380, no. 6646, American Association for the Advancement of Science, 2023, pp. 718–21, doi:<a href=\"https://doi.org/10.1126/science.adg3812\">10.1126/science.adg3812</a>.","ieee":"R. Sahu <i>et al.</i>, “Entangling microwaves with light,” <i>Science</i>, vol. 380, no. 6646. American Association for the Advancement of Science, pp. 718–721, 2023.","ama":"Sahu R, Qiu L, Hease WJ, et al. Entangling microwaves with light. <i>Science</i>. 2023;380(6646):718-721. doi:<a href=\"https://doi.org/10.1126/science.adg3812\">10.1126/science.adg3812</a>"},"scopus_import":"1","abstract":[{"text":"Quantum entanglement is a key resource in currently developed quantum technologies. Sharing this fragile property between superconducting microwave circuits and optical or atomic systems would enable new functionalities, but this has been hindered by an energy scale mismatch of >104 and the resulting mutually imposed loss and noise. In this work, we created and verified entanglement between microwave and optical fields in a millikelvin environment. Using an optically pulsed superconducting electro-optical device, we show entanglement between propagating microwave and optical fields in the continuous variable domain. This achievement not only paves the way for entanglement between superconducting circuits and telecom wavelength light, but also has wide-ranging implications for hybrid quantum networks in the context of modularization, scaling, sensing, and cross-platform verification.","lang":"eng"}],"keyword":["Multidisciplinary"],"oa_version":"Preprint","publisher":"American Association for the Advancement of Science","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2301.03315"}],"external_id":{"pmid":["37200415"],"isi":["000996515200004"],"arxiv":["2301.03315"]},"date_updated":"2026-04-15T06:39:33Z","quality_controlled":"1","month":"05","volume":380,"title":"Entangling microwaves with light","article_processing_charge":"No","date_published":"2023-05-18T00:00:00Z","arxiv":1,"acknowledgement":"This work was supported by the European Research Council (grant no. 758053, ERC StG QUNNECT) and the European Union’s Horizon 2020 Research and Innovation Program (grant no. 899354, FETopen SuperQuLAN). L.Q. acknowledges generous support from the ISTFELLOW program. W.H. is the recipient of an ISTplus postdoctoral fellowship with funding from the European Union’s Horizon 2020 Research and Innovation Program (Marie Sklodowska-Curie grant no. 754411). G.A. is the recipient of a DOC fellowship of the Austrian Academy of Sciences at IST Austria. J.M.F. acknowledges support from the Austrian Science Fund (FWF) through BeyondC (grant no. F7105) and the European Union’s Horizon 2020 Research and Innovation Program (grant no. 862644, FETopen QUARTET).","isi":1}]