[{"publist_id":"4271","date_updated":"2026-05-22T11:42:53Z","month":"05","article_processing_charge":"No","title":"Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry","date_created":"2018-12-11T11:58:45Z","_id":"2627","date_published":"2003-05-09T00:00:00Z","author":[{"full_name":"Kawakami, Ryosuke","last_name":"Kawakami","first_name":"Ryosuke"},{"full_name":"Shinohara, Yoshiaki","first_name":"Yoshiaki","last_name":"Shinohara"},{"first_name":"Yuichiro","last_name":"Kato","full_name":"Kato, Yuichiro"},{"last_name":"Sugiyama","first_name":"Hiroyuki","full_name":"Sugiyama, Hiroyuki"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi"},{"full_name":"Ito, Isao","last_name":"Ito","first_name":"Isao"}],"year":"2003","scopus_import":"1","type":"report","extern":"1","OA_type":"closed access","pmid":1,"publication_status":"published","publisher":"American Association for the Advancement of Science","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","page":"990 - 994","volume":300,"intvolume":"       300","fulldoi":"https://doi.org/10.1126/science.1082609","abstract":[{"lang":"eng","text":"Despite its implications for higher order functions of the brain, little is currently known about the molecular basis of left-right asymmetry of the brain. Here we report that synaptic distribution of N-methyl-D-aspartate (NMDA) receptor GluRε2 (NR2B) subunits in the adult mouse hippocampus is asymmetrical between the left and right and between the apical and basal dendrites of single neurons. These asymmetrical allocations of ε2 subunits differentiate the properties of NMDA receptors and synaptic plasticity between the left and right hippocampus. These results provide a molecular basis for the structural and functional asymmetry of the mature brain."}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"doi":"10.1126/science.1082609","status":"public","citation":{"mla":"Kawakami, Ryosuke, et al. <i>Asymmetrical Allocation of NMDA Receptor Ε2 Subunits in Hippocampal Circuitry</i>. Vol. 300, American Association for the Advancement of Science, 2003, pp. 990–94, doi:<a href=\"https://doi.org/10.1126/science.1082609\">10.1126/science.1082609</a>.","ieee":"R. Kawakami, Y. Shinohara, Y. Kato, H. Sugiyama, R. Shigemoto, and I. Ito, <i>Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry</i>, vol. 300. American Association for the Advancement of Science, 2003, pp. 990–994.","short":"R. Kawakami, Y. Shinohara, Y. Kato, H. Sugiyama, R. Shigemoto, I. Ito, Asymmetrical Allocation of NMDA Receptor Ε2 Subunits in Hippocampal Circuitry, American Association for the Advancement of Science, 2003.","ama":"Kawakami R, Shinohara Y, Kato Y, Sugiyama H, Shigemoto R, Ito I. <i>Asymmetrical Allocation of NMDA Receptor Ε2 Subunits in Hippocampal Circuitry</i>. Vol 300. American Association for the Advancement of Science; 2003:990-994. doi:<a href=\"https://doi.org/10.1126/science.1082609\">10.1126/science.1082609</a>","chicago":"Kawakami, Ryosuke, Yoshiaki Shinohara, Yuichiro Kato, Hiroyuki Sugiyama, Ryuichi Shigemoto, and Isao Ito. <i>Asymmetrical Allocation of NMDA Receptor Ε2 Subunits in Hippocampal Circuitry</i>. Vol. 300. American Association for the Advancement of Science, 2003. <a href=\"https://doi.org/10.1126/science.1082609\">https://doi.org/10.1126/science.1082609</a>.","apa":"Kawakami, R., Shinohara, Y., Kato, Y., Sugiyama, H., Shigemoto, R., &#38; Ito, I. (2003). <i>Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry</i> (Vol. 300, pp. 990–994). American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1082609\">https://doi.org/10.1126/science.1082609</a>","ista":"Kawakami R, Shinohara Y, Kato Y, Sugiyama H, Shigemoto R, Ito I. 2003. Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry, American Association for the Advancement of Science,p."},"oa_version":"None","external_id":{"pmid":["12738868"]},"day":"09"},{"_id":"9455","publication":"Science","date_published":"2003-01-31T00:00:00Z","author":[{"first_name":"Daniel","orcid":"0000-0002-0123-8649","last_name":"Zilberman","full_name":"Zilberman, Daniel","id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1"},{"first_name":" Xiaofeng","last_name":"Cao","full_name":"Cao,  Xiaofeng"},{"first_name":"Steven E.","last_name":"Jacobsen","full_name":"Jacobsen, Steven E."}],"article_processing_charge":"No","month":"01","date_updated":"2021-12-14T08:43:30Z","date_created":"2021-06-04T11:26:26Z","title":"ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation","article_type":"original","quality_controlled":"1","page":"716-719","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","publication_status":"published","publisher":"American Association for the Advancement of Science","extern":"1","department":[{"_id":"DaZi"}],"type":"journal_article","scopus_import":"1","year":"2003","pmid":1,"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Proteins of the ARGONAUTE family are important in diverse posttranscriptional RNA-mediated gene-silencing systems as well as in transcriptional gene silencing in Drosophila and fission yeast and in programmed DNA elimination in Tetrahymena. We cloned ARGONAUTE4 (AGO4) from a screen for mutants that suppress silencing of the Arabidopsis SUPERMAN(SUP) gene. The ago4-1 mutant reactivated silentSUP alleles and decreased CpNpG and asymmetric DNA methylation as well as histone H3 lysine-9 methylation. In addition,ago4-1 blocked histone and DNA methylation and the accumulation of 25-nucleotide small interfering RNAs (siRNAs) that correspond to the retroelement AtSN1. These results suggest that AGO4 and long siRNAs direct chromatin modifications, including histone methylation and non-CpG DNA methylation."}],"doi":"10.1126/science.1079695","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"volume":299,"fulldoi":"https://doi.org/10.1126/science.1079695","intvolume":"       299","issue":"5607","citation":{"ieee":"D. Zilberman,  Xiaofeng Cao, and S. E. Jacobsen, “ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation,” <i>Science</i>, vol. 299, no. 5607. American Association for the Advancement of Science, pp. 716–719, 2003.","short":"D. Zilberman,  Xiaofeng Cao, S.E. Jacobsen, Science 299 (2003) 716–719.","ama":"Zilberman D, Cao  Xiaofeng, Jacobsen SE. ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. <i>Science</i>. 2003;299(5607):716-719. doi:<a href=\"https://doi.org/10.1126/science.1079695\">10.1126/science.1079695</a>","chicago":"Zilberman, Daniel,  Xiaofeng Cao, and Steven E. Jacobsen. “ARGONAUTE4 Control of Locus-Specific SiRNA Accumulation and DNA and Histone Methylation.” <i>Science</i>. American Association for the Advancement of Science, 2003. <a href=\"https://doi.org/10.1126/science.1079695\">https://doi.org/10.1126/science.1079695</a>.","mla":"Zilberman, Daniel, et al. “ARGONAUTE4 Control of Locus-Specific SiRNA Accumulation and DNA and Histone Methylation.” <i>Science</i>, vol. 299, no. 5607, American Association for the Advancement of Science, 2003, pp. 716–19, doi:<a href=\"https://doi.org/10.1126/science.1079695\">10.1126/science.1079695</a>.","ista":"Zilberman D, Cao  Xiaofeng, Jacobsen SE. 2003. ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. Science. 299(5607), 716–719.","apa":"Zilberman, D., Cao,  Xiaofeng, &#38; Jacobsen, S. E. (2003). ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1079695\">https://doi.org/10.1126/science.1079695</a>"},"day":"31","oa_version":"None","external_id":{"pmid":["12522258"]},"keyword":["Multidisciplinary"],"status":"public"},{"publication_status":"published","publisher":"American Association for the Advancement of Science","page":"2077-2080","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","quality_controlled":"1","pmid":1,"type":"journal_article","year":"2001","scopus_import":"1","extern":"1","department":[{"_id":"DaZi"}],"date_published":"2001-06-15T00:00:00Z","author":[{"full_name":"Lindroth, A. M.","last_name":"Lindroth","first_name":"A. M."},{"full_name":"Cao, Xiaofeng","last_name":"Cao","first_name":"Xiaofeng"},{"first_name":"James P.","last_name":"Jackson","full_name":"Jackson, James P."},{"orcid":"0000-0002-0123-8649","last_name":"Zilberman","first_name":"Daniel","id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1","full_name":"Zilberman, Daniel"},{"last_name":"McCallum","first_name":"Claire M.","full_name":"McCallum, Claire M."},{"last_name":"Henikoff","first_name":"Steven","full_name":"Henikoff, Steven"},{"first_name":"Steven E.","last_name":"Jacobsen","full_name":"Jacobsen, Steven E."}],"publication":"Science","_id":"9444","article_type":"original","title":"Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation","date_created":"2021-06-02T13:35:16Z","date_updated":"2021-12-14T08:40:32Z","month":"06","article_processing_charge":"No","oa_version":"None","external_id":{"pmid":["11349138"]},"keyword":["Multidisciplinary"],"day":"15","citation":{"ama":"Lindroth AM, Cao X, Jackson JP, et al. Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation. <i>Science</i>. 2001;292(5524):2077-2080. doi:<a href=\"https://doi.org/10.1126/science.1059745\">10.1126/science.1059745</a>","chicago":"Lindroth, A. M., Xiaofeng Cao, James P. Jackson, Daniel Zilberman, Claire M. McCallum, Steven Henikoff, and Steven E. Jacobsen. “Requirement of CHROMOMETHYLASE3 for Maintenance of CpXpG Methylation.” <i>Science</i>. American Association for the Advancement of Science, 2001. <a href=\"https://doi.org/10.1126/science.1059745\">https://doi.org/10.1126/science.1059745</a>.","short":"A.M. Lindroth, X. Cao, J.P. Jackson, D. Zilberman, C.M. McCallum, S. Henikoff, S.E. Jacobsen, Science 292 (2001) 2077–2080.","ieee":"A. M. Lindroth <i>et al.</i>, “Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation,” <i>Science</i>, vol. 292, no. 5524. American Association for the Advancement of Science, pp. 2077–2080, 2001.","mla":"Lindroth, A. M., et al. “Requirement of CHROMOMETHYLASE3 for Maintenance of CpXpG Methylation.” <i>Science</i>, vol. 292, no. 5524, American Association for the Advancement of Science, 2001, pp. 2077–80, doi:<a href=\"https://doi.org/10.1126/science.1059745\">10.1126/science.1059745</a>.","ista":"Lindroth AM, Cao X, Jackson JP, Zilberman D, McCallum CM, Henikoff S, Jacobsen SE. 2001. Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation. Science. 292(5524), 2077–2080.","apa":"Lindroth, A. M., Cao, X., Jackson, J. P., Zilberman, D., McCallum, C. M., Henikoff, S., &#38; Jacobsen, S. E. (2001). Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1059745\">https://doi.org/10.1126/science.1059745</a>"},"issue":"5524","status":"public","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"doi":"10.1126/science.1059745","abstract":[{"text":"Epigenetic silenced alleles of the Arabidopsis SUPERMANlocus (the clark kent alleles) are associated with dense hypermethylation at noncanonical cytosines (CpXpG and asymmetric sites, where X = A, T, C, or G). A genetic screen for suppressors of a hypermethylated clark kent mutant identified nine loss-of-function alleles of CHROMOMETHYLASE3(CMT3), a novel cytosine methyltransferase homolog. These cmt3 mutants display a wild-type morphology but exhibit decreased CpXpG methylation of the SUP gene and of other sequences throughout the genome. They also show reactivated expression of endogenous retrotransposon sequences. These results show that a non-CpG DNA methyltransferase is responsible for maintaining epigenetic gene silencing.","lang":"eng"}],"language":[{"iso":"eng"}],"intvolume":"       292","fulldoi":"https://doi.org/10.1126/science.1059745","volume":292}]