---
OA_type: closed access
_id: '21371'
abstract:
- lang: eng
text: There may be a newly identified early phase of supermassive black hole growth
acknowledgement: The author acknowledges the support from the European Union (European
Research Council, AGENTS, 101076224).
article_processing_charge: No
article_type: comment
author:
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
citation:
ama: Matthee JJ. Black holes disguised as little red dots. Science. 2026;391(6787):767-768.
doi:10.1126/science.adz8603
apa: Matthee, J. J. (2026). Black holes disguised as little red dots. Science.
AAAS. https://doi.org/10.1126/science.adz8603
chicago: Matthee, Jorryt J. “Black Holes Disguised as Little Red Dots.” Science.
AAAS, 2026. https://doi.org/10.1126/science.adz8603.
ieee: J. J. Matthee, “Black holes disguised as little red dots,” Science,
vol. 391, no. 6787. AAAS, pp. 767–768, 2026.
ista: Matthee JJ. 2026. Black holes disguised as little red dots. Science. 391(6787),
767–768.
mla: Matthee, Jorryt J. “Black Holes Disguised as Little Red Dots.” Science,
vol. 391, no. 6787, AAAS, 2026, pp. 767–68, doi:10.1126/science.adz8603.
short: J.J. Matthee, Science 391 (2026) 767–768.
corr_author: '1'
date_created: 2026-03-01T23:01:39Z
date_published: 2026-02-19T00:00:00Z
date_updated: 2026-03-02T09:15:45Z
day: '19'
department:
- _id: JoMa
doi: 10.1126/science.adz8603
external_id:
pmid:
- '41712710'
fulldoi: https://doi.org/10.1126/science.adz8603
intvolume: ' 391'
issue: '6787'
language:
- iso: eng
month: '02'
oa_version: None
page: 767-768
pmid: 1
project:
- _id: bd9b2118-d553-11ed-ba76-db24564edfea
grant_number: '101076224'
name: Young galaxies as tracers and agents of cosmic reionization
publication: Science
publication_identifier:
eissn:
- 1095-9203
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: Black holes disguised as little red dots
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 391
year: '2026'
...
---
OA_type: closed access
_id: '22365'
abstract:
- lang: eng
text: Phase plates can, in principle, overcome the poor image contrast in cryo–electron
microscopy (cryo-EM) and the resulting limits on the structural reconstruction
of small proteins. However, previous designs have been unstable and compromised
the high-resolution signal and have thus been unable to surpass results achieved
by standard cryo-EM. Here, we show that the laser phase plate (LPP), installed
in a modern, custom Titan Krios microscope, enhances the resolution in single-particle
reconstruction of small proteins by improving specimen-motion correction and recovery
of information from the early frames, as well as particle visualization, three-dimensional
classification, and alignment. These advances use standard defocus ranges and
reconstruction procedures but open the door to LPP-tailored protocols, offering
further improvements by leveraging the LPP demonstrated here.
acknowledgement: 'The authors thank O. Schwartz and S. Scheres for helpful remarks
and discussions; D. Agard, B. Carragher, C. Potter, and P. Olshin for close collaboration;
A. Singh, L. Maisenbacher, S. Strasser, and I. Pope for help with mirror inspection;
J. Fang, E. Nogales, and J. Hurley for sharing their lab space and assisting with
sample preparation; B. Buijsse, W. Hagen, B. Jiang, and T. Coyle at Thermo Fisher
Scientific for the design of the custom transfer optics and technical support; G.
Long and T. Gutierrez at the UC Berkeley Physics R&D Machine Shop for machining
cavity components and tooling. This work was supported by the following: Chan Zuckerberg
Initiative award numbers 2021-234606 and 2025-367757, National Institutes of Health
grant R01GM126011, Gordon and Betty Moore Foundation grant 9366, Lawrence Berkeley
National Laboratory Directed Research and Development Program grant 25-111, and
Cooperative Research and Development Agreement award AWD00004352 (to H.M.); National
Institutes of Health fellowship F32GM149186 (to P.N.P.).'
article_processing_charge: No
article_type: original
author:
- first_name: Petar N
full_name: Petrov, Petar N
id: b1d6732d-8cb6-11f0-baab-bd460ee3a287
last_name: Petrov
- first_name: Jessie T.
full_name: Zhang, Jessie T.
last_name: Zhang
- first_name: Jonathan
full_name: Remis, Jonathan
last_name: Remis
- first_name: Jeremy J.
full_name: Axelrod, Jeremy J.
last_name: Axelrod
- first_name: Hang
full_name: Cheng, Hang
last_name: Cheng
- first_name: Eric S.
full_name: Cooper, Eric S.
last_name: Cooper
- first_name: Ian K.
full_name: Hicklin, Ian K.
last_name: Hicklin
- first_name: Shahar
full_name: Sandhaus, Shahar
last_name: Sandhaus
- first_name: Cooper
full_name: Schnurr, Cooper
last_name: Schnurr
- first_name: Robert M.
full_name: Glaeser, Robert M.
last_name: Glaeser
- first_name: Holger
full_name: Müller, Holger
last_name: Müller
citation:
ama: Petrov PN, Zhang JT, Remis J, et al. Laser phase plate improves structure determination
of small proteins by cryo-EM. Science. 2026;393(6807):195-196. doi:10.1126/science.aeh0665
apa: Petrov, P. N., Zhang, J. T., Remis, J., Axelrod, J. J., Cheng, H., Cooper,
E. S., … Müller, H. (2026). Laser phase plate improves structure determination
of small proteins by cryo-EM. Science. AAAS. https://doi.org/10.1126/science.aeh0665
chicago: Petrov, Petar N, Jessie T. Zhang, Jonathan Remis, Jeremy J. Axelrod, Hang
Cheng, Eric S. Cooper, Ian K. Hicklin, et al. “Laser Phase Plate Improves Structure
Determination of Small Proteins by Cryo-EM.” Science. AAAS, 2026. https://doi.org/10.1126/science.aeh0665.
ieee: P. N. Petrov et al., “Laser phase plate improves structure determination
of small proteins by cryo-EM,” Science, vol. 393, no. 6807. AAAS, pp. 195–196,
2026.
ista: Petrov PN, Zhang JT, Remis J, Axelrod JJ, Cheng H, Cooper ES, Hicklin IK,
Sandhaus S, Schnurr C, Glaeser RM, Müller H. 2026. Laser phase plate improves
structure determination of small proteins by cryo-EM. Science. 393(6807), 195–196.
mla: Petrov, Petar N., et al. “Laser Phase Plate Improves Structure Determination
of Small Proteins by Cryo-EM.” Science, vol. 393, no. 6807, AAAS, 2026,
pp. 195–96, doi:10.1126/science.aeh0665.
short: P.N. Petrov, J.T. Zhang, J. Remis, J.J. Axelrod, H. Cheng, E.S. Cooper, I.K.
Hicklin, S. Sandhaus, C. Schnurr, R.M. Glaeser, H. Müller, Science 393 (2026)
195–196.
das_tickbox: '1'
dataavailabilitystatement: 'The datasets are publicly available in the Electron Microscopy
Public Image Archive [A1: EMPIAR-13528 (on), EMPIAR-13527 (off); A2: EMPIAR-13529
(on), EMPIAR-13526 (off); A3: EMPIAR-13530 (on), EMPIAR-13525 (off); H1: EMPIAR-13535
(on), EMPIAR-13533 (off); H2: EMPIAR-13534 (on), EMPIAR-13532 (off); H3: EMPIAR-13537
(on), EMPIAR-13531 (off)]. The final reconstructed maps are deposited in the Electron
Microscopy Data Bank [A1: EMD-76790 (on), EMD-76791 (off); A2: EMD-76792 (on), EMD-76793
(off); A3: EMD-76794 (on), EMD-76797 (off); H1: EMD-76802 (on), EMD-76804 (off);
H2: EMD-76805 (on), EMD-76806 (off); H3: EMD-76807 (on), EMD-76809 (off)]. The initial
structures in Fig. 3 are deposited at EMD-76810 (on) and EMD-76811 (off). Code for
converting EER movies to binned TIF format with proper accounting for electron dose
is deposited in Zenodo (47) and available on GitHub at https://github.com/matterwaves/eer2tiff/releases/tag/v0.1.0.
All specimen preparation materials are commercially available.'
date_created: 2026-07-19T22:01:46Z
date_published: 2026-07-09T00:00:00Z
date_updated: 2026-08-05T09:27:38Z
day: '09'
ddc:
- '570'
department:
- _id: MiLe
doi: 10.1126/science.aeh0665
external_id:
pmid:
- '42275466'
fulldoi: https://doi.org/10.1126/science.aeh0665
has_accepted_license: '1'
intvolume: ' 393'
issue: '6807'
language:
- iso: eng
month: '07'
oa_version: None
page: 195-196
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Laser phase plate improves structure determination of small proteins by cryo-EM
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 393
year: '2026'
...
---
OA_type: closed access
_id: '21762'
abstract:
- lang: eng
text: Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular
organization. The plasmid-encoded ParMRC system forms actin-like filaments that
segregate low–copy number plasmids. In multicellular cyanobacteria such as Anabaena
sp., we found that a chromosomally encoded ParMR system has evolved into a cytoskeletal
system named CorMR with a function in cell shape control rather than DNA segregation.
Live-cell imaging, in vitro reconstitution, and cryo–electron microscopy revealed
that CorM formed dynamically unstable, antiparallel double-stranded filaments
that were recruited to the membrane by CorR through an amphipathic helix conserved
in multicellular cyanobacteria. CorMR filaments were regulated by MinC, which
excluded them from the poles and division plane. Comparative genomics indicated
that the repurposing of ParMR and Min systems coevolved with cyanobacterial multicellularity,
highlighting the evolutionary plasticity of cytoskeletal systems in bacteria.
acknowledged_ssus:
- _id: Bio
- _id: ScienComp
- _id: EM-Fac
- _id: LifeSc
acknowledgement: "We thank all members of the Loose lab at ISTA for helpful discussions;
M. Kojic for critical reading of the manuscript; A. Herrero (Sevilla University)
for sharing her extensive BACTH plasmid library and other plasmids, as well as cyanobacterial
strains; T. Dagan and F. Nies (both Kiel University) for sharing cyanobacterial
strains and plasmids and for valuable discussions; N. Sapay and A. Michon for providing
the Amphipaseek code, which enabled us to perform our large-scale amphipathic helix
screen of cyanobacterial CorR proteins; V.-V. Hodirnau for support in cryo-ET data
collection; and J. Hansen for advice about cryo-EM data processing.\r\nThis work
was supported by the Scientific Service Units (SSU) of ISTA through resources provided
by the Imaging & Optics Facility (IOF), the Scientific Computing (SciComp), the
Electron Microscopy Facility (EMF), and the Lab Support Facility (LSF). This work
was funded by the European Union’s Horizon 2020 research and innovation program
(Marie Skłodowska-Curie grant 101034413 to B.L.S.); the European Research Council
(ERC) of the European Union (grant ActinID 101076260 to F.K.M.S.); the Swiss National
Science Foundation (starting grant TMSGI3_226208 to G.L.W.); and the Jean-Jacques
et Letitia Lopez-Loreta Foundation (G.L.W.)."
article_number: eaea6343
article_processing_charge: No
article_type: original
author:
- first_name: Benjamin L
full_name: Springstein, Benjamin L
id: b4eb62ef-ac72-11ed-9503-ed3b4d66c083
last_name: Springstein
orcid: 0000-0002-3461-5391
- first_name: Manjunath
full_name: Javoor, Manjunath
id: 305ab18b-dc7d-11ea-9b2f-b58195228ea2
last_name: Javoor
orcid: 0000-0003-2311-2112
- first_name: Daniela
full_name: Megrian, Daniela
last_name: Megrian
- first_name: Roman
full_name: Hajdu, Roman
id: ffab949d-133f-11ed-8f02-94de21ace503
last_name: Hajdu
- first_name: Dustin M.
full_name: Hanke, Dustin M.
last_name: Hanke
- first_name: Bettina
full_name: Zens, Bettina
id: 45FD126C-F248-11E8-B48F-1D18A9856A87
last_name: Zens
orcid: 0000-0002-9561-1239
- first_name: Gregor L.
full_name: Weiss, Gregor L.
last_name: Weiss
- first_name: Florian Km
full_name: Schur, Florian Km
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
- first_name: Martin
full_name: Loose, Martin
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
citation:
ama: Springstein BL, Javoor M, Megrian D, et al. Repurposing of a DNA segregation
machinery into a cytoskeletal system controlling cell shape. Science. 2026;392(6795).
doi:10.1126/science.aea6343
apa: Springstein, B. L., Javoor, M., Megrian, D., Hajdu, R., Hanke, D. M., Zens,
B., … Loose, M. (2026). Repurposing of a DNA segregation machinery into a cytoskeletal
system controlling cell shape. Science. AAAS. https://doi.org/10.1126/science.aea6343
chicago: Springstein, Benjamin L, Manjunath Javoor, Daniela Megrian, Roman Hajdu,
Dustin M. Hanke, Bettina Zens, Gregor L. Weiss, Florian KM Schur, and Martin Loose.
“Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling
Cell Shape.” Science. AAAS, 2026. https://doi.org/10.1126/science.aea6343.
ieee: B. L. Springstein et al., “Repurposing of a DNA segregation machinery
into a cytoskeletal system controlling cell shape,” Science, vol. 392,
no. 6795. AAAS, 2026.
ista: Springstein BL, Javoor M, Megrian D, Hajdu R, Hanke DM, Zens B, Weiss GL,
Schur FK, Loose M. 2026. Repurposing of a DNA segregation machinery into a cytoskeletal
system controlling cell shape. Science. 392(6795), eaea6343.
mla: Springstein, Benjamin L., et al. “Repurposing of a DNA Segregation Machinery
into a Cytoskeletal System Controlling Cell Shape.” Science, vol. 392,
no. 6795, eaea6343, AAAS, 2026, doi:10.1126/science.aea6343.
short: B.L. Springstein, M. Javoor, D. Megrian, R. Hajdu, D.M. Hanke, B. Zens, G.L.
Weiss, F.K. Schur, M. Loose, Science 392 (2026).
corr_author: '1'
date_created: 2026-04-26T22:01:46Z
date_published: 2026-04-16T00:00:00Z
date_updated: 2026-09-03T09:36:24Z
day: '16'
department:
- _id: MaLo
- _id: FlSc
- _id: GradSch
- _id: EM-Fac
doi: 10.1126/science.aea6343
ec_funded: 1
external_id:
pmid:
- '41990175'
fulldoi: https://doi.org/10.1126/science.aea6343
intvolume: ' 392'
issue: '6795'
language:
- iso: eng
month: '04'
oa_version: None
pmid: 1
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
- _id: bd980d18-d553-11ed-ba76-ceaa645c97eb
grant_number: '101076260'
name: A molecular atlas of Actin filament IDentities in the cell motility machinery
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
related_material:
record:
- id: '22744'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Repurposing of a DNA segregation machinery into a cytoskeletal system controlling
cell shape
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 392
year: '2026'
...
---
OA_type: closed access
_id: '23000'
abstract:
- lang: eng
text: Ancient viral warfare could be at the root of modern class 1 CRISPR bacterial
defense systems
article_processing_charge: No
article_type: comment
author:
- first_name: Jack Peter Kelly
full_name: Bravo, Jack Peter Kelly
id: 96aecfa5-8931-11ee-af30-aa6a5d6eee0e
last_name: Bravo
orcid: 0000-0003-0456-0753
citation:
ama: Bravo JPK. A viral origin for RNA-guided immunity. Science. 2026;393(6817):1187-1188.
doi:10.1126/science.ael0758
apa: Bravo, J. P. K. (2026). A viral origin for RNA-guided immunity. Science.
AAAS. https://doi.org/10.1126/science.ael0758
chicago: Bravo, Jack Peter Kelly. “A Viral Origin for RNA-Guided Immunity.” Science.
AAAS, 2026. https://doi.org/10.1126/science.ael0758.
ieee: J. P. K. Bravo, “A viral origin for RNA-guided immunity,” Science,
vol. 393, no. 6817. AAAS, pp. 1187–1188, 2026.
ista: Bravo JPK. 2026. A viral origin for RNA-guided immunity. Science. 393(6817),
1187–1188.
mla: Bravo, Jack Peter Kelly. “A Viral Origin for RNA-Guided Immunity.” Science,
vol. 393, no. 6817, AAAS, 2026, pp. 1187–88, doi:10.1126/science.ael0758.
short: J.P.K. Bravo, Science 393 (2026) 1187–1188.
corr_author: '1'
das_tickbox: '0'
date_created: 2026-09-27T22:01:52Z
date_published: 2026-09-17T00:00:00Z
date_updated: 2026-10-07T08:10:18Z
day: '17'
department:
- _id: JaBr
doi: 10.1126/science.ael0758
external_id:
pmid:
- '42752153'
fulldoi: https://doi.org/10.1126/science.ael0758
intvolume: ' 393'
issue: '6817'
language:
- iso: eng
month: '09'
oa_version: None
page: 1187-1188
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: A viral origin for RNA-guided immunity
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 393
year: '2026'
...
---
OA_type: closed access
_id: '22315'
abstract:
- lang: eng
text: Plant tropisms enable roots to navigate complex soils by responding to directional
environmental cues. Biological decay, although central to nutrient cycling, also
creates microbially active and potentially hostile niches. In this work, we identified
“saprotropism,” a previously unrecognized growth response that enables roots to
actively bend away from decaying plant-derived matter. Fungal-driven microbial
decomposition released organic acids and formed stable pH gradients in surrounding
soil, allowing roots to pinpoint decay without direct contact. Root epidermal
cells sensed this acidic gradient through the root meristem growth factor peptide-receptor
module, converting external pH asymmetry into asymmetric abscisic acid (ABA) distribution.
ABA asymmetry drove microtubule reorganization, which was decoded into decay-avoidant
root bending. Together, these findings establish microbial decay–derived chemical
gradients as an instructive signal for root navigation and expand the framework
of microbe-soil-plant communication.
acknowledgement: 'We are grateful to H. Guo and L. Liu (Department of Biology, Southern
University of Science and Technology) for providing the rgf1/2/3, rgi1/2/3/4, tpst-1,
and pepr1/2 lines. We thank K.-h. Liu (College of Life Science, Northwest A&F University)
for generously providing the ABA biosensor nlsABACUS2-400n. We also thank J. Li
and J. Chang (School of Life Sciences, Lanzhou University) for providing the ahk2-5/cre1-2,
ahp1/2/3, arr16/arr17, and pTCSn::GFP lines. Our thanks further extend to D. Qian,
also from the School of Life Sciences at Lanzhou University, for sharing Arabidopsis
line pTUB6::mCherry-TUB6. We are grateful to Y. Zhao (CAS Center for Excellence
in Molecular Plant Sciences, Chinese Academy of Sciences) for providing nced3/5,
snrk2.2/2.3/2.6, and pyl duodecuple mutants. We also acknowledge the Teaching and
Research Core Facility at the College of Life Sciences, Northwest A&F University,
particularly N. Fan, for their invaluable technical assistance. We also thank Life
Science Research Core Services (LSRCS), Northwest A&F University, for helping with
characterization, including CLSM (X. Liu). Fundamental and Interdisciplinary Disciplines
Breakthrough Plan of the Ministry of Education of China JYB2025XDXM706 (Y.Z.); Qin
Chuangyuan High-level Innovation and Entrepreneurship Talent Program QCYRCXM-2022-237
(Y.Z.); Fundamental Research Funds for the Central Universities K20200168 (Y.Z.);
National Natural Science Foundation of China 32570375 (Y.Z.); National Natural Science
Foundation of China 32400699 (A.Z.); European Research Council (ERC, CYNIPS) 101142681
(J.F.); Austrian Science Fund (FWF): P 37051-B (J.F.).'
article_number: eadw6568
article_processing_charge: No
article_type: original
author:
- first_name: Zhulatai
full_name: Bao, Zhulatai
last_name: Bao
- first_name: Huihui
full_name: Wang, Huihui
last_name: Wang
- first_name: Ai
full_name: Zhang, Ai
last_name: Zhang
- first_name: Ruxi
full_name: Gao, Ruxi
last_name: Gao
- first_name: Wen
full_name: Gu, Wen
last_name: Gu
- first_name: Ni
full_name: Fan, Ni
last_name: Fan
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Yuzhou
full_name: Zhang, Yuzhou
last_name: Zhang
citation:
ama: Bao Z, Wang H, Zhang A, et al. Roots navigate around decay regions by sensing
local pH gradients. Science. 2026;393(6807). doi:10.1126/science.adw6568
apa: Bao, Z., Wang, H., Zhang, A., Gao, R., Gu, W., Fan, N., … Zhang, Y. (2026).
Roots navigate around decay regions by sensing local pH gradients. Science.
AAAS. https://doi.org/10.1126/science.adw6568
chicago: Bao, Zhulatai, Huihui Wang, Ai Zhang, Ruxi Gao, Wen Gu, Ni Fan, Jiří Friml,
and Yuzhou Zhang. “Roots Navigate around Decay Regions by Sensing Local PH Gradients.”
Science. AAAS, 2026. https://doi.org/10.1126/science.adw6568.
ieee: Z. Bao et al., “Roots navigate around decay regions by sensing local
pH gradients,” Science, vol. 393, no. 6807. AAAS, 2026.
ista: Bao Z, Wang H, Zhang A, Gao R, Gu W, Fan N, Friml J, Zhang Y. 2026. Roots
navigate around decay regions by sensing local pH gradients. Science. 393(6807),
eadw6568.
mla: Bao, Zhulatai, et al. “Roots Navigate around Decay Regions by Sensing Local
PH Gradients.” Science, vol. 393, no. 6807, eadw6568, AAAS, 2026, doi:10.1126/science.adw6568.
short: Z. Bao, H. Wang, A. Zhang, R. Gao, W. Gu, N. Fan, J. Friml, Y. Zhang, Science
393 (2026).
das_tickbox: '1'
dataavailabilitystatement: All data are available in the manuscript or the supplementary
materials. The raw RNA-seq data have been deposited in the NCBI Gene Expression
Omnibus (GEO) under accession number GSE315473. Microbiome sequencing data have
been deposited in the Sequence Read Archive (SRA) under BioProject number PRJNA1397137.
Materials are available upon request from the corresponding author.
date_created: 2026-07-13T14:57:10Z
date_published: 2026-07-09T00:00:00Z
date_updated: 2026-10-20T08:12:03Z
day: '09'
department:
- _id: JiFr
doi: 10.1126/science.adw6568
external_id:
pmid:
- '42424472'
fulldoi: https://doi.org/10.1126/science.adw6568
intvolume: ' 393'
issue: '6807'
language:
- iso: eng
month: '07'
oa_version: None
pmid: 1
project:
- _id: 8f347782-16d5-11f0-9cad-8c19706ee739
grant_number: '101142681'
name: Cyclic nucleotides as second messengers in plants
- _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6
grant_number: P37051
name: Guanylate cyclase activity of TIR1/AFBs auxin receptors
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
related_material:
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relation: press_release
url: https://ista.ac.at/en/news/roots-steer-clear-of-plant-rot/
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Roots navigate around decay regions by sensing local pH gradients
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 393
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21763'
abstract:
- lang: eng
text: Reactive oxygen species (ROS) have been implicated in multiple signaling processes
in plants, but the underlying mechanisms and roles remain enigmatic. In this study,
we developed a method of live imaging of apoplastic ROS at the root surface. Distinct
signals, including auxin, extracellular adenosine triphosphate, and rapid alkalinization
factor 1 peptide, induce cytosolic calcium transients and apoplastic ROS bursts.
Genetic and optogenetic manipulations of Arabidopsis identified calcium transients
as necessary and sufficient for ROS bursts through activation of reduced nicotinamide
adenine dinucleotide phosphate (NADPH) oxidases RBOHC and RBOHF. Apoplastic ROS
bursts are not required, but they do limit gravity-induced root bending. Root
bending is sensed by the stretch-activated calcium channel MCA1, leading to NADPH
oxidase activation. The resulting ROS production stiffens cell walls to facilitate
soil penetration. Apoplastic ROS thus provides a means to balance tissue flexibility
and stiffness to navigate soil.
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
acknowledgement: "We gratefully acknowledge the Lab Support Facility (LSF) and the
Imaging and Optics Facility (IOF) (both of ISTA) and the Hounsfield CT Facility
(University of Nottingham) for support with imaging and the Growth Facility (IPMB)
for plant cultivation. We thank M. Fendrych and his team for help with the microfluidics
upgrades and J. Atkinson at the University of Nottingham MakerSpace for 3D printing
of Arabidopsis mini-soil columns.\r\nThis project received funding from the European
Research Council (ERC; 101142681 CYNIPS) and the Austrian Science Fund (FWF; P 37051-B).
I.K. was cofunded by the European Union, Horizon Europe, project MOLIPEC, ID 101087030
and CSF project 25-16449S. L.V. and B.K.P. acknowledge funding from UK Research
and Innovation (UKRI) Frontiers Research (EP/Y036697/1). M.J.B. acknowledges funding
from ERC SYNERGY (grant 101118769 HYDROSENSING). The study was partially supported
by the Université Paris Cité, Idex ANR-18-IDEX-0001, funded by the French Government
through its “Investments for the Future” program and also by the projects “Mecha-Nuc”
ANR-20-CE13-0025-03 and “scEm-bryoMech” ANR-21-CE13-0046. P.D. acknowledges support
by Human Frontier Science Program Organization grant 2022-RG107. P.V. acknowledges
support provided by “Programme blanc” of the Graduate School BIOSPHERA, Université
Paris-Saclay. Phytohormonal analysis was performed using the service laboratory
funded by Toward Next GENeration Crops, reg. no. CZ.02.01.01/00/22_008/0004581 of
the European Regional Development Fund (ERDF) program Johannes Amos Comenius. This
research was funded in whole or in part by the Austrian Science Fund (P 37051-B)
and UK Research and Innovation (EP/Y036697/1), cOAlition S organizations, and by
the European Research Council (101142681 CYNIPS, 101118769 HYDROSENSING); as required,
the author will make the Author Accepted Manuscript (AAM) version available under
a CC BY public copyright license."
article_processing_charge: No
article_type: original
author:
- first_name: Ivan
full_name: Kulich, Ivan
id: 57a1567c-8314-11eb-9063-c9ddc3451a54
last_name: Kulich
- first_name: Dmitrii
full_name: Vladimirtsev, Dmitrii
id: 60466724-5355-11ee-ae5a-fa55e8f99c3d
last_name: Vladimirtsev
- first_name: Marek
full_name: Randuch, Marek
id: 6ac4636d-15b2-11ec-abd3-fb8df79972ae
last_name: Randuch
- first_name: Shiqiang
full_name: Gao, Shiqiang
last_name: Gao
- first_name: Matteo
full_name: Citterico, Matteo
last_name: Citterico
- first_name: Kai R.
full_name: Konrad, Kai R.
last_name: Konrad
- first_name: Georg
full_name: Nagel, Georg
last_name: Nagel
- first_name: Michael
full_name: Wrzaczek, Michael
last_name: Wrzaczek
- first_name: Léa
full_name: Cascaro, Léa
last_name: Cascaro
- first_name: Pauline
full_name: Vinet, Pauline
last_name: Vinet
- first_name: Pauline
full_name: Durand, Pauline
last_name: Durand
- first_name: Atef
full_name: Asnacios, Atef
last_name: Asnacios
- first_name: Lokesh
full_name: Verma, Lokesh
last_name: Verma
- first_name: Malcolm J.
full_name: Bennett, Malcolm J.
last_name: Bennett
- first_name: Bipin K.
full_name: Pandey, Bipin K.
last_name: Pandey
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Kulich I, Vladimirtsev D, Randuch M, et al. Calcium-triggered apoplastic ROS
bursts balance gravity and mechanical signals for soil navigation. Science.
2026;392(6795):296-300. doi:10.1126/science.adu8197
apa: Kulich, I., Vladimirtsev, D., Randuch, M., Gao, S., Citterico, M., Konrad,
K. R., … Friml, J. (2026). Calcium-triggered apoplastic ROS bursts balance gravity
and mechanical signals for soil navigation. Science. AAAS. https://doi.org/10.1126/science.adu8197
chicago: Kulich, Ivan, Dmitrii Vladimirtsev, Marek Randuch, Shiqiang Gao, Matteo
Citterico, Kai R. Konrad, Georg Nagel, et al. “Calcium-Triggered Apoplastic ROS
Bursts Balance Gravity and Mechanical Signals for Soil Navigation.” Science.
AAAS, 2026. https://doi.org/10.1126/science.adu8197.
ieee: I. Kulich et al., “Calcium-triggered apoplastic ROS bursts balance
gravity and mechanical signals for soil navigation,” Science, vol. 392,
no. 6795. AAAS, pp. 296–300, 2026.
ista: Kulich I, Vladimirtsev D, Randuch M, Gao S, Citterico M, Konrad KR, Nagel
G, Wrzaczek M, Cascaro L, Vinet P, Durand P, Asnacios A, Verma L, Bennett MJ,
Pandey BK, Friml J. 2026. Calcium-triggered apoplastic ROS bursts balance gravity
and mechanical signals for soil navigation. Science. 392(6795), 296–300.
mla: Kulich, Ivan, et al. “Calcium-Triggered Apoplastic ROS Bursts Balance Gravity
and Mechanical Signals for Soil Navigation.” Science, vol. 392, no. 6795,
AAAS, 2026, pp. 296–300, doi:10.1126/science.adu8197.
short: I. Kulich, D. Vladimirtsev, M. Randuch, S. Gao, M. Citterico, K.R. Konrad,
G. Nagel, M. Wrzaczek, L. Cascaro, P. Vinet, P. Durand, A. Asnacios, L. Verma,
M.J. Bennett, B.K. Pandey, J. Friml, Science 392 (2026) 296–300.
corr_author: '1'
date_created: 2026-04-26T22:01:47Z
date_published: 2026-04-16T00:00:00Z
date_updated: 2026-10-22T09:15:44Z
day: '16'
ddc:
- '580'
department:
- _id: JiFr
- _id: GradSch
doi: 10.1126/science.adu8197
external_id:
pmid:
- '41990180'
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date_created: 2026-05-07T05:54:43Z
date_updated: 2026-05-07T05:54:43Z
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file_size: 6150733
relation: main_file
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file_date_updated: 2026-05-07T05:54:43Z
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intvolume: ' 392'
issue: '6795'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Accepted Version
page: 296-300
pmid: 1
project:
- _id: 8f347782-16d5-11f0-9cad-8c19706ee739
grant_number: '101142681'
name: Cyclic nucleotides as second messengers in plants
- _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6
grant_number: P37051
name: Guanylate cyclase activity of TIR1/AFBs auxin receptors
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
related_material:
record:
- id: '23145'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals
for soil navigation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 392
year: '2026'
...
---
OA_type: closed access
_id: '18985'
abstract:
- lang: eng
text: Persistent multiyear drought (MYD) events pose a growing threat to nature
and humans in a changing climate. We identified and inventoried global MYDs by
detecting spatiotemporally contiguous climatic anomalies, showing that MYDs have
become drier, hotter, and led to increasingly diminished vegetation greenness.
The global terrestrial land affected by MYDs has increased at a rate of 49,279
± 14,771 square kilometers per year from 1980 to 2018. Temperate grasslands have
exhibited the greatest declines in vegetation greenness during MYDs, whereas boreal
and tropical forests have had comparably minor responses. With MYDs becoming more
common, this global quantitative inventory of the occurrence, severity, trend,
and impact of MYDs provides an important benchmark for facilitating more effective
and collaborative preparedness toward mitigation of and adaptation to such extreme
events.
acknowledgement: This study received support from the Extremes Research Program funded
by the Swiss Federal Institute for Forest, Snow and Landscape Research (WSL) within
the EMERGE project of the Extremes program.
article_processing_charge: No
article_type: original
author:
- first_name: Liangzhi
full_name: Chen, Liangzhi
last_name: Chen
- first_name: Philipp
full_name: Brun, Philipp
last_name: Brun
- first_name: Pascal
full_name: Buri, Pascal
id: 317987aa-9421-11ee-ac5a-b941b041abba
last_name: Buri
- first_name: Simone
full_name: Fatichi, Simone
last_name: Fatichi
- first_name: Arthur
full_name: Gessler, Arthur
last_name: Gessler
- first_name: Michael
full_name: Mccarthy, Michael
id: 22a2674a-61ce-11ee-94b5-d18813baf16f
last_name: Mccarthy
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
orcid: 0000-0002-5554-8087
- first_name: Benjamin
full_name: Stocker, Benjamin
last_name: Stocker
- first_name: Dirk Nikolaus
full_name: Karger, Dirk Nikolaus
last_name: Karger
citation:
ama: Chen L, Brun P, Buri P, et al. Global increase in the occurrence and impact
of multiyear droughts. Science. 2025;387(6731):278-284. doi:10.1126/science.ado4245
apa: Chen, L., Brun, P., Buri, P., Fatichi, S., Gessler, A., McCarthy, M., … Karger,
D. N. (2025). Global increase in the occurrence and impact of multiyear droughts.
Science. AAAS. https://doi.org/10.1126/science.ado4245
chicago: Chen, Liangzhi, Philipp Brun, Pascal Buri, Simone Fatichi, Arthur Gessler,
Michael McCarthy, Francesca Pellicciotti, Benjamin Stocker, and Dirk Nikolaus
Karger. “Global Increase in the Occurrence and Impact of Multiyear Droughts.”
Science. AAAS, 2025. https://doi.org/10.1126/science.ado4245.
ieee: L. Chen et al., “Global increase in the occurrence and impact of multiyear
droughts,” Science, vol. 387, no. 6731. AAAS, pp. 278–284, 2025.
ista: Chen L, Brun P, Buri P, Fatichi S, Gessler A, McCarthy M, Pellicciotti F,
Stocker B, Karger DN. 2025. Global increase in the occurrence and impact of multiyear
droughts. Science. 387(6731), 278–284.
mla: Chen, Liangzhi, et al. “Global Increase in the Occurrence and Impact of Multiyear
Droughts.” Science, vol. 387, no. 6731, AAAS, 2025, pp. 278–84, doi:10.1126/science.ado4245.
short: L. Chen, P. Brun, P. Buri, S. Fatichi, A. Gessler, M. McCarthy, F. Pellicciotti,
B. Stocker, D.N. Karger, Science 387 (2025) 278–284.
date_created: 2025-02-02T23:01:54Z
date_published: 2025-01-17T00:00:00Z
date_updated: 2025-09-30T10:24:34Z
day: '17'
department:
- _id: FrPe
doi: 10.1126/science.ado4245
external_id:
isi:
- '001491931700027'
pmid:
- '39818908'
fulldoi: https://doi.org/10.1126/science.ado4245
intvolume: ' 387'
isi: 1
issue: '6731'
language:
- iso: eng
month: '01'
oa_version: None
page: 278-284
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: Global increase in the occurrence and impact of multiyear droughts
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 387
year: '2025'
...
---
OA_type: closed access
_id: '19364'
abstract:
- lang: eng
text: Thermoelectric coolers (TECs) are pivotal in modern heat management but face
limitations in efficiency and manufacturing scalability. We address these challenges
by using an extrusion-based 3D printing technique to fabricate high-performance
thermoelectric materials. Our ink formulations ensure the integrity of the 3D-printed
structure and effective particle bonding during sintering, achieving record-high
figure of merit (zT) values of 1.42 for p-type bismuth antimony telluride [(Bi,Sb)2Te3]
and 1.3 for n-type silver selenide (Ag2Se) materials at room temperature. The
resulting TEC demonstrates a cooling temperature gradient of 50°C in air. Moreover,
this scalable and cost-effective method circumvents energy-intensive and time-consuming
steps, such as ingot preparation and subsequently machining processes, offering
a transformative solution for thermoelectric device production and heralding a
new era of efficient and sustainable thermoelectric technologies.
acknowledged_ssus:
- _id: EM-Fac
- _id: LifeSc
- _id: M-Shop
- _id: NanoFab
acknowledgement: This work was supported by the Scientific Service Units (SSU) of
ISTA through resources provided by the Electron Microscopy Facility (EMF), the Lab
Support Facility (LSF), the Communication & Events facility, the Miba Machine Shop,
and the Nanofabrication Facility (NNF). The Mechanical Response of Materials (MRM)
Service Unit of the Technical University of Wien is acknowledged for Mechanical
tests. X. L. Yan and S. Bühler-Paschen (Institute of Solid-State Physics, Technical
University of Wien) are acknowledged for granting us access to their equipment,
which allowed us to perform independent corroborative measurements. M. Qin is acknowledged
for help with Au deposition and wire bonding for samples used for PPMS measurements.
The lab of B. Hof and Z. Lu is acknowledged for help with rheological properties
measurements. The members of the Ibáñez research group, especially N. Jakhar, C.
Fiedler, and T. Kleinhanns, are acknowledged for their feedback on the manuscript
and fruitful discussions. This work was financially supported by ISTA and the Werner
Siemens Foundation.
article_processing_charge: No
article_type: original
author:
- first_name: Shengduo
full_name: Xu, Shengduo
id: 12ab8624-4c8a-11ec-9e11-e1ac2438f22f
last_name: Xu
- first_name: Sharona
full_name: Horta, Sharona
id: 03a7e858-01b1-11ec-8b71-99ae6c4a05bc
last_name: Horta
- first_name: Abayomi Q
full_name: Lawal, Abayomi Q
id: 5bdaf946-5355-11ee-ae5a-8061700bd605
last_name: Lawal
- first_name: Krishnendu
full_name: Maji, Krishnendu
id: 76bc9e9f-ba0b-11ee-8184-90edabd17a58
last_name: Maji
- first_name: Magali
full_name: Lorion, Magali
id: bc07ac4d-142e-11eb-a9d5-d72db792859d
last_name: Lorion
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
citation:
ama: Xu S, Horta S, Lawal AQ, Maji K, Lorion M, Ibáñez M. Interfacial bonding enhances
thermoelectric cooling in 3D-printed materials. Science. 2025;387(6736):845-850.
doi:10.1126/science.ads0426
apa: Xu, S., Horta, S., Lawal, A. Q., Maji, K., Lorion, M., & Ibáñez, M. (2025).
Interfacial bonding enhances thermoelectric cooling in 3D-printed materials. Science.
AAAS. https://doi.org/10.1126/science.ads0426
chicago: Xu, Shengduo, Sharona Horta, Abayomi Q Lawal, Krishnendu Maji, Magali Lorion,
and Maria Ibáñez. “Interfacial Bonding Enhances Thermoelectric Cooling in 3D-Printed
Materials.” Science. AAAS, 2025. https://doi.org/10.1126/science.ads0426.
ieee: S. Xu, S. Horta, A. Q. Lawal, K. Maji, M. Lorion, and M. Ibáñez, “Interfacial
bonding enhances thermoelectric cooling in 3D-printed materials,” Science,
vol. 387, no. 6736. AAAS, pp. 845–850, 2025.
ista: Xu S, Horta S, Lawal AQ, Maji K, Lorion M, Ibáñez M. 2025. Interfacial bonding
enhances thermoelectric cooling in 3D-printed materials. Science. 387(6736), 845–850.
mla: Xu, Shengduo, et al. “Interfacial Bonding Enhances Thermoelectric Cooling in
3D-Printed Materials.” Science, vol. 387, no. 6736, AAAS, 2025, pp. 845–50,
doi:10.1126/science.ads0426.
short: S. Xu, S. Horta, A.Q. Lawal, K. Maji, M. Lorion, M. Ibáñez, Science 387 (2025)
845–850.
corr_author: '1'
date_created: 2025-03-09T23:01:26Z
date_published: 2025-02-20T00:00:00Z
date_updated: 2026-04-28T13:43:53Z
day: '20'
department:
- _id: MaIb
doi: 10.1126/science.ads0426
external_id:
isi:
- '001514422600026'
pmid:
- '39977506'
fulldoi: https://doi.org/10.1126/science.ads0426
intvolume: ' 387'
isi: 1
issue: '6736'
language:
- iso: eng
month: '02'
oa_version: None
page: 845-850
pmid: 1
project:
- _id: 9B8F7476-BA93-11EA-9121-9846C619BF3A
name: 'HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of
Semiconductors for Waste Heat Recovery'
publication: Science
publication_identifier:
eissn:
- 1095-9203
publication_status: published
publisher: AAAS
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/cooling-materials-out-of-the-3d-printer/
scopus_import: '1'
status: public
title: Interfacial bonding enhances thermoelectric cooling in 3D-printed materials
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 387
year: '2025'
...
---
OA_type: closed access
_id: '20532'
abstract:
- lang: eng
text: A unified mechanism directs synaptic vesicle release
acknowledgement: The author thanks P. Jonas for feedback on the manuscript and acknowledges
support from the European Union’s Horizon 2020 research and innovation program under
Marie Skłodowska-Curie grant agreement no. 101034413.
article_processing_charge: No
article_type: comment
author:
- first_name: Katharina
full_name: Lichter, Katharina
id: 39302e62-fcfc-11ec-8196-8b01447dbd3d
last_name: Lichter
orcid: 0000-0002-1485-0351
citation:
ama: Lichter K. Kiss, shrink, run. Science. 2025;390(6770):236-237. doi:10.1126/science.aec0091
apa: Lichter, K. (2025). Kiss, shrink, run. Science. AAAS. https://doi.org/10.1126/science.aec0091
chicago: Lichter, Katharina. “Kiss, Shrink, Run.” Science. AAAS, 2025. https://doi.org/10.1126/science.aec0091.
ieee: K. Lichter, “Kiss, shrink, run,” Science, vol. 390, no. 6770. AAAS,
pp. 236–237, 2025.
ista: Lichter K. 2025. Kiss, shrink, run. Science. 390(6770), 236–237.
mla: Lichter, Katharina. “Kiss, Shrink, Run.” Science, vol. 390, no. 6770,
AAAS, 2025, pp. 236–37, doi:10.1126/science.aec0091.
short: K. Lichter, Science 390 (2025) 236–237.
corr_author: '1'
date_created: 2025-10-26T23:01:34Z
date_published: 2025-10-16T00:00:00Z
date_updated: 2025-12-01T15:04:34Z
day: '16'
department:
- _id: PeJo
doi: 10.1126/science.aec0091
ec_funded: 1
external_id:
isi:
- '001610669900024'
pmid:
- '41100630'
fulldoi: https://doi.org/10.1126/science.aec0091
intvolume: ' 390'
isi: 1
issue: '6770'
language:
- iso: eng
month: '10'
oa_version: None
page: 236-237
pmid: 1
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: Kiss, shrink, run
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 390
year: '2025'
...
---
OA_type: closed access
_id: '22562'
abstract:
- lang: eng
text: Persistent multiyear drought (MYD) events pose a growing threat to nature
and humans in a changing climate. We identified and inventoried global MYDs by
detecting spatiotemporally contiguous climatic anomalies, showing that MYDs have
become drier, hotter, and led to increasingly diminished vegetation greenness.
The global terrestrial land affected by MYDs has increased at a rate of 49,279
± 14,771 square kilometers per year from 1980 to 2018. Temperate grasslands have
exhibited the greatest declines in vegetation greenness during MYDs, whereas boreal
and tropical forests have had comparably minor responses. With MYDs becoming more
common, this global quantitative inventory of the occurrence, severity, trend,
and impact of MYDs provides an important benchmark for facilitating more effective
and collaborative preparedness toward mitigation of and adaptation to such extreme
events.
article_processing_charge: No
article_type: original
author:
- first_name: Liangzhi
full_name: Chen, Liangzhi
last_name: Chen
- first_name: Philipp
full_name: Brun, Philipp
last_name: Brun
- first_name: Pascal
full_name: Buri, Pascal
last_name: Buri
- first_name: Simone
full_name: Fatichi, Simone
id: cf8e546b-a9b0-11f0-a43b-aa89ed1b56d6
last_name: Fatichi
- first_name: Arthur
full_name: Gessler, Arthur
last_name: Gessler
- first_name: Michael James
full_name: McCarthy, Michael James
last_name: McCarthy
- first_name: Francesca
full_name: Pellicciotti, Francesca
last_name: Pellicciotti
- first_name: Benjamin
full_name: Stocker, Benjamin
last_name: Stocker
- first_name: Dirk Nikolaus
full_name: Karger, Dirk Nikolaus
last_name: Karger
citation:
ama: Chen L, Brun P, Buri P, et al. Global increase in the occurrence and impact
of multiyear droughts. Science. 2025;387(6731):278-284. doi:10.1126/science.ado4245
apa: Chen, L., Brun, P., Buri, P., Fatichi, S., Gessler, A., McCarthy, M. J., …
Karger, D. N. (2025). Global increase in the occurrence and impact of multiyear
droughts. Science. AAAS. https://doi.org/10.1126/science.ado4245
chicago: Chen, Liangzhi, Philipp Brun, Pascal Buri, Simone Fatichi, Arthur Gessler,
Michael James McCarthy, Francesca Pellicciotti, Benjamin Stocker, and Dirk Nikolaus
Karger. “Global Increase in the Occurrence and Impact of Multiyear Droughts.”
Science. AAAS, 2025. https://doi.org/10.1126/science.ado4245.
ieee: L. Chen et al., “Global increase in the occurrence and impact of multiyear
droughts,” Science, vol. 387, no. 6731. AAAS, pp. 278–284, 2025.
ista: Chen L, Brun P, Buri P, Fatichi S, Gessler A, McCarthy MJ, Pellicciotti F,
Stocker B, Karger DN. 2025. Global increase in the occurrence and impact of multiyear
droughts. Science. 387(6731), 278–284.
mla: Chen, Liangzhi, et al. “Global Increase in the Occurrence and Impact of Multiyear
Droughts.” Science, vol. 387, no. 6731, AAAS, 2025, pp. 278–84, doi:10.1126/science.ado4245.
short: L. Chen, P. Brun, P. Buri, S. Fatichi, A. Gessler, M.J. McCarthy, F. Pellicciotti,
B. Stocker, D.N. Karger, Science 387 (2025) 278–284.
das_tickbox: '1'
date_created: 2026-07-27T12:30:24Z
date_published: 2025-01-17T00:00:00Z
date_updated: 2026-08-07T10:47:08Z
day: '17'
doi: 10.1126/science.ado4245
extern: '1'
fulldoi: https://doi.org/10.1126/science.ado4245
intvolume: ' 387'
issue: '6731'
language:
- iso: eng
month: '01'
oa_version: None
page: 278-284
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: Global increase in the occurrence and impact of multiyear droughts
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 387
year: '2025'
...
---
OA_type: closed access
_id: '21817'
abstract:
- lang: eng
text: 'Ambidirectionality, which is the ability of structural elements to move beyond
a reference state in two opposite directions, is common in nature. However, conventional
soft materials are typically limited to a single, unidirectional deformation unless
complex hybrid constructs are used. We exploited the combination of mesogen self-assembly,
polymer chain elasticity, and polymerization-induced stress to design liquid crystalline
elastomers that exhibit two mesophases: chevron smectic C (cSmC) and smectic A
(SmA). Inducing the cSmC-SmA–isotropic phase transition led to an unusual inversion
of the strain field in the microstructure, resulting in opposite deformation modes
(e.g., consecutive shrinkage or expansion and right-handed or left-handed twisting
and tilting in opposite directions) and high-frequency nonmonotonic oscillations.
This ambidirectional movement is scalable and can be used to generate Gaussian
transformations at the macroscale.'
article_processing_charge: No
article_type: original
author:
- first_name: Yuxing
full_name: Yao, Yuxing
last_name: Yao
- first_name: Atalaya Milan
full_name: Wilborn, Atalaya Milan
last_name: Wilborn
- first_name: Baptiste
full_name: Lemaire, Baptiste
last_name: Lemaire
- first_name: Foteini
full_name: Trigka, Foteini
last_name: Trigka
- first_name: Friedrich J
full_name: Stricker, Friedrich J
id: 7aca2cfc-46cf-11f0-abd3-8c96b5186745
last_name: Stricker
- first_name: Alan H.
full_name: Weible, Alan H.
last_name: Weible
- first_name: Shucong
full_name: Li, Shucong
last_name: Li
- first_name: Robert K. A.
full_name: Bennett, Robert K. A.
last_name: Bennett
- first_name: Tung Chun
full_name: Cheung, Tung Chun
last_name: Cheung
- first_name: Alison
full_name: Grinthal, Alison
last_name: Grinthal
- first_name: Mikhail
full_name: Zhernenkov, Mikhail
last_name: Zhernenkov
- first_name: Guillaume
full_name: Freychet, Guillaume
last_name: Freychet
- first_name: Patryk
full_name: Wąsik, Patryk
last_name: Wąsik
- first_name: Boris
full_name: Kozinsky, Boris
last_name: Kozinsky
- first_name: Michael M.
full_name: Lerch, Michael M.
last_name: Lerch
- first_name: Xiaoguang
full_name: Wang, Xiaoguang
last_name: Wang
- first_name: Joanna
full_name: Aizenberg, Joanna
last_name: Aizenberg
citation:
ama: Yao Y, Wilborn AM, Lemaire B, et al. Programming liquid crystal elastomers
for multistep ambidirectional deformability. Science. 2024;386(6726):1161-1168.
doi:10.1126/science.adq6434
apa: Yao, Y., Wilborn, A. M., Lemaire, B., Trigka, F., Stricker, F. J., Weible,
A. H., … Aizenberg, J. (2024). Programming liquid crystal elastomers for multistep
ambidirectional deformability. Science. American Association for the Advancement
of Science. https://doi.org/10.1126/science.adq6434
chicago: Yao, Yuxing, Atalaya Milan Wilborn, Baptiste Lemaire, Foteini Trigka, Friedrich
J Stricker, Alan H. Weible, Shucong Li, et al. “Programming Liquid Crystal Elastomers
for Multistep Ambidirectional Deformability.” Science. American Association
for the Advancement of Science, 2024. https://doi.org/10.1126/science.adq6434.
ieee: Y. Yao et al., “Programming liquid crystal elastomers for multistep
ambidirectional deformability,” Science, vol. 386, no. 6726. American Association
for the Advancement of Science, pp. 1161–1168, 2024.
ista: Yao Y, Wilborn AM, Lemaire B, Trigka F, Stricker FJ, Weible AH, Li S, Bennett
RKA, Cheung TC, Grinthal A, Zhernenkov M, Freychet G, Wąsik P, Kozinsky B, Lerch
MM, Wang X, Aizenberg J. 2024. Programming liquid crystal elastomers for multistep
ambidirectional deformability. Science. 386(6726), 1161–1168.
mla: Yao, Yuxing, et al. “Programming Liquid Crystal Elastomers for Multistep Ambidirectional
Deformability.” Science, vol. 386, no. 6726, American Association for the
Advancement of Science, 2024, pp. 1161–68, doi:10.1126/science.adq6434.
short: Y. Yao, A.M. Wilborn, B. Lemaire, F. Trigka, F.J. Stricker, A.H. Weible,
S. Li, R.K.A. Bennett, T.C. Cheung, A. Grinthal, M. Zhernenkov, G. Freychet, P.
Wąsik, B. Kozinsky, M.M. Lerch, X. Wang, J. Aizenberg, Science 386 (2024) 1161–1168.
date_created: 2026-05-06T10:54:51Z
date_published: 2024-12-06T00:00:00Z
date_updated: 2026-05-12T09:48:12Z
day: '06'
ddc:
- '540'
doi: 10.1126/science.adq6434
extern: '1'
external_id:
pmid:
- '39636998'
fulldoi: https://doi.org/10.1126/science.adq6434
intvolume: ' 386'
issue: '6726'
language:
- iso: eng
month: '12'
oa_version: None
page: 1161-1168
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Programming liquid crystal elastomers for multistep ambidirectional deformability
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 386
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '17112'
abstract:
- lang: eng
text: The generation of cyclic oligoadenylates and subsequent allosteric activation
of proteins that carry sensory domains is a distinctive feature of type III CRISPR-Cas
systems. In this work, we characterize a set of associated genes of a type III-B
system from Haliangium ochraceum that contains two caspase-like proteases, SAVED-CHAT
and PCaspase (prokaryotic caspase), co-opted from a cyclic oligonucleotide–based
antiphage signaling system (CBASS). Cyclic tri–adenosine monophosphate (AMP)–induced
oligomerization of SAVED-CHAT activates proteolytic activity of the CHAT domains,
which specifically cleave and activate PCaspase. Subsequently, activated PCaspase
cleaves a multitude of proteins, which results in a strong interference phenotype
in vivo in Escherichia coli. Taken together, our findings reveal how a CRISPR-Cas–based
detection of a target RNA triggers a cascade of caspase-associated proteolytic
activities.
acknowledgement: We thank R. Fregoso Ocampo for assistance with negative-stain EM
imaging. This work was funded by Dutch Research Council (NWO) VIDI grant VI.Vidi.203.074
(R.H.J.S.), NWO Spinoza grant SPI 93-537 (J.v.d.O.), European Research Council (ERC)
Advanced grant ERC-AdG-834279 (J.v.d.O.), ERC CoG grant 817834 (T.J.G.E.), NWO VICI
grant VI.C.192.016 (T.J.G.E.), Volkswagen Foundation grant 96725 (T.J.G.E.), National
Institute of General Medical Sciences of the National Institutes of Health grant
R35GM138348 (D.W.T.), Welch Foundation research grant F-1938 (D.W.T.), a Robert
J. Kleberg, Jr. And Helen C. Kleberg Foundation medical research grant (D.W.T.),
and American Cancer Society Research Scholar grant RSG-21-050-01-DMC (D.W.T.).
article_processing_charge: No
article_type: original
author:
- first_name: Jurre A.
full_name: Steens, Jurre A.
last_name: Steens
- first_name: Jack Peter Kelly
full_name: Bravo, Jack Peter Kelly
id: 96aecfa5-8931-11ee-af30-aa6a5d6eee0e
last_name: Bravo
orcid: 0000-0003-0456-0753
- first_name: Carl Raymund P.
full_name: Salazar, Carl Raymund P.
last_name: Salazar
- first_name: Caglar
full_name: Yildiz, Caglar
last_name: Yildiz
- first_name: Afonso M.
full_name: Amieiro, Afonso M.
last_name: Amieiro
- first_name: Stephan
full_name: Köstlbacher, Stephan
last_name: Köstlbacher
- first_name: Stijn H.P.
full_name: Prinsen, Stijn H.P.
last_name: Prinsen
- first_name: Constantinos
full_name: Patinios, Constantinos
last_name: Patinios
- first_name: Andreas
full_name: Bardis, Andreas
last_name: Bardis
- first_name: Arjan
full_name: Barendregt, Arjan
last_name: Barendregt
- first_name: Richard A.
full_name: Scheltema, Richard A.
last_name: Scheltema
- first_name: Thijs J.G.
full_name: Ettema, Thijs J.G.
last_name: Ettema
- first_name: John
full_name: van der Oost, John
last_name: van der Oost
- first_name: David W.
full_name: Taylor, David W.
last_name: Taylor
- first_name: Raymond H.J.
full_name: Staals, Raymond H.J.
last_name: Staals
citation:
ama: Steens JA, Bravo JPK, Salazar CRP, et al. Type III-B CRISPR-Cas cascade of
proteolytic cleavages. Science. 2024;383(6682):512-519. doi:10.1126/science.adk0378
apa: Steens, J. A., Bravo, J. P. K., Salazar, C. R. P., Yildiz, C., Amieiro, A.
M., Köstlbacher, S., … Staals, R. H. J. (2024). Type III-B CRISPR-Cas cascade
of proteolytic cleavages. Science. American Association for the Advancement
of Science. https://doi.org/10.1126/science.adk0378
chicago: Steens, Jurre A., Jack Peter Kelly Bravo, Carl Raymund P. Salazar, Caglar
Yildiz, Afonso M. Amieiro, Stephan Köstlbacher, Stijn H.P. Prinsen, et al. “Type
III-B CRISPR-Cas Cascade of Proteolytic Cleavages.” Science. American Association
for the Advancement of Science, 2024. https://doi.org/10.1126/science.adk0378.
ieee: J. A. Steens et al., “Type III-B CRISPR-Cas cascade of proteolytic
cleavages,” Science, vol. 383, no. 6682. American Association for the Advancement
of Science, pp. 512–519, 2024.
ista: Steens JA, Bravo JPK, Salazar CRP, Yildiz C, Amieiro AM, Köstlbacher S, Prinsen
SHP, Patinios C, Bardis A, Barendregt A, Scheltema RA, Ettema TJG, van der Oost
J, Taylor DW, Staals RHJ. 2024. Type III-B CRISPR-Cas cascade of proteolytic cleavages.
Science. 383(6682), 512–519.
mla: Steens, Jurre A., et al. “Type III-B CRISPR-Cas Cascade of Proteolytic Cleavages.”
Science, vol. 383, no. 6682, American Association for the Advancement of
Science, 2024, pp. 512–19, doi:10.1126/science.adk0378.
short: J.A. Steens, J.P.K. Bravo, C.R.P. Salazar, C. Yildiz, A.M. Amieiro, S. Köstlbacher,
S.H.P. Prinsen, C. Patinios, A. Bardis, A. Barendregt, R.A. Scheltema, T.J.G.
Ettema, J. van der Oost, D.W. Taylor, R.H.J. Staals, Science 383 (2024) 512–519.
date_created: 2024-06-04T06:41:26Z
date_published: 2024-02-01T00:00:00Z
date_updated: 2025-09-24T08:31:45Z
day: '01'
doi: 10.1126/science.adk0378
extern: '1'
external_id:
pmid:
- '38301007'
fulldoi: https://doi.org/10.1126/science.adk0378
intvolume: ' 383'
issue: '6682'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2023.06.23.546230
month: '02'
oa: 1
oa_version: Preprint
page: 512-519
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Type III-B CRISPR-Cas cascade of proteolytic cleavages
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 383
year: '2024'
...
---
_id: '15117'
abstract:
- lang: eng
text: 'The hippocampal mossy fiber synapse, formed between axons of dentate gyrus
granule cells and dendrites of CA3 pyramidal neurons, is a key synapse in the
trisynaptic circuitry of the hippocampus. Because of its comparatively large size,
this synapse is accessible to direct presynaptic recording, allowing a rigorous
investigation of the biophysical mechanisms of synaptic transmission and plasticity.
Furthermore, because of its placement in the very center of the hippocampal memory
circuit, this synapse seems to be critically involved in several higher network
functions, such as learning, memory, pattern separation, and pattern completion.
Recent work based on new technologies in both nanoanatomy and nanophysiology,
including presynaptic patch-clamp recording, paired recording, super-resolution
light microscopy, and freeze-fracture and “flash-and-freeze” electron microscopy,
has provided new insights into the structure, biophysics, and network function
of this intriguing synapse. This brings us one step closer to answering a fundamental
question in neuroscience: how basic synaptic properties shape higher network computations.'
acknowledgement: "We thank previous students, postdocs, and collaborators, particularly
J. Geiger, and (in alphabetical order) H. Alle, J. Bischofberger, C. Borges-Merjane,
D. Engel, M. Frotscher, S. Hallermann, M. Heckmann, S. Jamrichova, O. Kim, L. Li,
K. Lichter, P. Lin, J. Lübke, Y. Okamoto, C. Pawlu, C. Schmidt-Hieber, N. Spruston,
and N. Vyleta for their outstanding experimental contributions. We also thank P.
Castillo, J. Geiger, T. Sakaba, S. Siegert, T. Vogels, and J. Watson for critically
reading the manuscript, E. Kralli-Beller for text editing, and J. Malikovic and
L. Slomianka for useful discussions. We apologize that, due to space constraints,
not all relevant papers could be cited.\r\nThis project was supported by the European
Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
program (grant agreement 692692, AdG “GIANTSYN”) and the Fonds zur Förderung der
Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein Award; P 36232-B, stand-alone
grant), both to P.J."
article_processing_charge: No
article_type: review
author:
- first_name: David H
full_name: Vandael, David H
id: 3AE48E0A-F248-11E8-B48F-1D18A9856A87
last_name: Vandael
orcid: 0000-0001-7577-1676
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Vandael DH, Jonas PM. Structure, biophysics, and circuit function of a “giant”
cortical presynaptic terminal. Science. 2024;383(6687):eadg6757. doi:10.1126/science.adg6757
apa: Vandael, D. H., & Jonas, P. M. (2024). Structure, biophysics, and circuit
function of a “giant” cortical presynaptic terminal. Science. AAAS. https://doi.org/10.1126/science.adg6757
chicago: Vandael, David H, and Peter M Jonas. “Structure, Biophysics, and Circuit
Function of a ‘Giant’ Cortical Presynaptic Terminal.” Science. AAAS, 2024.
https://doi.org/10.1126/science.adg6757.
ieee: D. H. Vandael and P. M. Jonas, “Structure, biophysics, and circuit function
of a ‘giant’ cortical presynaptic terminal,” Science, vol. 383, no. 6687.
AAAS, p. eadg6757, 2024.
ista: Vandael DH, Jonas PM. 2024. Structure, biophysics, and circuit function of
a ‘giant’ cortical presynaptic terminal. Science. 383(6687), eadg6757.
mla: Vandael, David H., and Peter M. Jonas. “Structure, Biophysics, and Circuit
Function of a ‘Giant’ Cortical Presynaptic Terminal.” Science, vol. 383,
no. 6687, AAAS, 2024, p. eadg6757, doi:10.1126/science.adg6757.
short: D.H. Vandael, P.M. Jonas, Science 383 (2024) eadg6757.
corr_author: '1'
das_tickbox: '0'
date_created: 2024-03-17T23:00:57Z
date_published: 2024-03-08T00:00:00Z
date_updated: 2026-09-17T09:49:03Z
day: '08'
department:
- _id: PeJo
doi: 10.1126/science.adg6757
ec_funded: 1
external_id:
isi:
- '001216996700015'
pmid:
- '38452088'
fulldoi: https://doi.org/10.1126/science.adg6757
intvolume: ' 383'
isi: 1
issue: '6687'
language:
- iso: eng
month: '03'
oa_version: None
page: eadg6757
pmid: 1
project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '692692'
name: Biophysics and circuit function of a giant cortical glutamatergic synapse
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00312
name: Synaptic communication in neuronal microcircuits
- _id: bd88be38-d553-11ed-ba76-81d5a70a6ef5
grant_number: P36232
name: Mechanisms of GABA release in hippocampal circuits
publication: Science
publication_identifier:
eissn:
- 1095-9203
publication_status: published
publisher: AAAS
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Structure, biophysics, and circuit function of a "giant" cortical presynaptic
terminal
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 383
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '18446'
abstract:
- lang: eng
text: How living systems achieve precision in form and function despite their intrinsic
stochasticity is a fundamental yet ongoing question in biology. We generated morphomaps
of preimplantation embryogenesis in mouse, rabbit, and monkey embryos, and these
morphomaps revealed that although blastomere divisions desynchronized passively,
8-cell embryos converged toward robust three-dimensional shapes. Using topological
analysis and genetic perturbations, we found that embryos progressively changed
their cellular connectivity to a preferred topology, which could be predicted
by a physical model in which actomyosin contractility and noise facilitate topological
transitions, lowering surface energy. This mechanism favored regular embryo packing
and promoted a higher number of inner cells in the 16-cell embryo. Synchronized
division reduced embryo packing and generated substantially more misallocated
cells and fewer inner-cell–mass cells. These findings suggest that stochasticity
in division timing contributes to robust patterning.
acknowledgement: "We are grateful to the members of the Hiiragi laboratory for discussions
and comments on the manuscript: R. Bloehs, S. Friese, S. Hozeifi, L. Pérez, and
W. Schwarzer for their technical support; V. Janssen for establishing the PAB protocol;
members of the Tsukiyama group for the animal care with monkeys, in particular H.
Tsuchiya and M. Nakaya; Unité Commune d’Expérimentation Animale (UCEA, Jouy-en-Josas,
France) for the animal care with rabbits; the EMBL electronic and mechanical workshops
and the EMBL animal facility for their support; We thank Luxendo for the close collaboration
in developing the light-sheet microscopy for mammalian embryos.\r\nFunding: This
work was funded by the following: EMBL Interdisciplinary Postdoc Program (EIPOD)
under Marie Sklodowska Curie Actions COFUND III RTD (to D.F.); JSPS Overseas Research
Fellowship (to T.I.); Field of excellence “Complexity of life in basic research
and innovation” of the University of Graz (to B.C.M.); European Research Council,
ERC Advanced Grant “SelforganisingEmbryo”, grant agreement 742732; ERC Advanced
Grant “COORDINATION” grant agreement 101055287 (to T.H.); Stichting LSH-TKI, grant
LSHM21020 (to T.H.) JSPS KAKENHI grants JP21H05038 and JP22H05166 (to T.H.)"
article_number: eadh1145
article_processing_charge: No
article_type: original
author:
- first_name: Dimitri
full_name: Fabrèges, Dimitri
last_name: Fabrèges
- first_name: Bernat
full_name: Corominas-Murtra, Bernat
id: 43BE2298-F248-11E8-B48F-1D18A9856A87
last_name: Corominas-Murtra
orcid: 0000-0001-9806-5643
- first_name: Prachiti
full_name: Moghe, Prachiti
last_name: Moghe
- first_name: Alison
full_name: Kickuth, Alison
last_name: Kickuth
- first_name: Takafumi
full_name: Ichikawa, Takafumi
last_name: Ichikawa
- first_name: Chizuru
full_name: Iwatani, Chizuru
last_name: Iwatani
- first_name: Tomoyuki
full_name: Tsukiyama, Tomoyuki
last_name: Tsukiyama
- first_name: Nathalie
full_name: Daniel, Nathalie
last_name: Daniel
- first_name: Julie
full_name: Gering, Julie
last_name: Gering
- first_name: Anniek
full_name: Stokkermans, Anniek
last_name: Stokkermans
- first_name: Adrian
full_name: Wolny, Adrian
last_name: Wolny
- first_name: Anna
full_name: Kreshuk, Anna
last_name: Kreshuk
- first_name: Véronique
full_name: Duranthon, Véronique
last_name: Duranthon
- first_name: Virginie
full_name: Uhlman, Virginie
last_name: Uhlman
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Takashi
full_name: Hiiragi, Takashi
last_name: Hiiragi
citation:
ama: Fabrèges D, Corominas-Murtra B, Moghe P, et al. Temporal variability and cell
mechanics control robustness in mammalian embryogenesis. Science. 2024;386(6718).
doi:10.1126/science.adh1145
apa: Fabrèges, D., Corominas-Murtra, B., Moghe, P., Kickuth, A., Ichikawa, T., Iwatani,
C., … Hiiragi, T. (2024). Temporal variability and cell mechanics control robustness
in mammalian embryogenesis. Science. AAAS. https://doi.org/10.1126/science.adh1145
chicago: Fabrèges, Dimitri, Bernat Corominas-Murtra, Prachiti Moghe, Alison Kickuth,
Takafumi Ichikawa, Chizuru Iwatani, Tomoyuki Tsukiyama, et al. “Temporal Variability
and Cell Mechanics Control Robustness in Mammalian Embryogenesis.” Science.
AAAS, 2024. https://doi.org/10.1126/science.adh1145.
ieee: D. Fabrèges et al., “Temporal variability and cell mechanics control
robustness in mammalian embryogenesis,” Science, vol. 386, no. 6718. AAAS,
2024.
ista: Fabrèges D, Corominas-Murtra B, Moghe P, Kickuth A, Ichikawa T, Iwatani C,
Tsukiyama T, Daniel N, Gering J, Stokkermans A, Wolny A, Kreshuk A, Duranthon
V, Uhlman V, Hannezo EB, Hiiragi T. 2024. Temporal variability and cell mechanics
control robustness in mammalian embryogenesis. Science. 386(6718), eadh1145.
mla: Fabrèges, Dimitri, et al. “Temporal Variability and Cell Mechanics Control
Robustness in Mammalian Embryogenesis.” Science, vol. 386, no. 6718, eadh1145,
AAAS, 2024, doi:10.1126/science.adh1145.
short: D. Fabrèges, B. Corominas-Murtra, P. Moghe, A. Kickuth, T. Ichikawa, C. Iwatani,
T. Tsukiyama, N. Daniel, J. Gering, A. Stokkermans, A. Wolny, A. Kreshuk, V. Duranthon,
V. Uhlman, E.B. Hannezo, T. Hiiragi, Science 386 (2024).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: "All original code and data reported in this paper is publicly
available as of the date of publication on Zenodo (124).\r\n124\r\nD. Fabrèges,
B. Corominas-Murtra, P. Moghe, A. Kickuth, T. Ichikawa, C. Iwatani, T. Tsukiyama,
N. Daniel, J. Gering, A. Stokkermans, A. Wolny, A. Kreshuk, V. Duranthon, V. Uhlmann,
E. Hannezo, T. Hiiragi, Temporal variability and cell mechanics control robustness
in mammalian embryogenesis, version 1.0, Zenodo (2024); https://doi.org/10.5281/ZENODO.12819781."
date_created: 2024-10-20T22:02:06Z
date_published: 2024-10-11T00:00:00Z
date_updated: 2026-10-01T10:54:32Z
day: '11'
department:
- _id: EdHa
doi: 10.1126/science.adh1145
external_id:
isi:
- '001422132300018'
pmid:
- '39388574'
fulldoi: https://doi.org/10.1126/science.adh1145
intvolume: ' 386'
isi: 1
issue: '6718'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://hal.inrae.fr/hal-04447081v1/file/2023.01.24.525420.full.pdf
month: '10'
oa: 1
oa_version: Submitted Version
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
publication_status: published
publisher: AAAS
quality_controlled: '1'
related_material:
record:
- id: '23023'
relation: research_data
status: public
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Temporal variability and cell mechanics control robustness in mammalian embryogenesis
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 386
year: '2024'
...
---
_id: '17091'
abstract:
- lang: eng
text: DNA sequences are connected to genes and functions in the developing and adult
brain
article_processing_charge: No
article_type: letter_note
author:
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
- first_name: Christoph
full_name: Bock, Christoph
last_name: Bock
citation:
ama: Novarino G, Bock C. Mapping the brain’s gene-regulatory maze. Science.
2024;384(6698):860-861. doi:10.1126/science.adp4663
apa: Novarino, G., & Bock, C. (2024). Mapping the brain’s gene-regulatory maze.
Science. AAAS. https://doi.org/10.1126/science.adp4663
chicago: Novarino, Gaia, and Christoph Bock. “Mapping the Brain’s Gene-Regulatory
Maze.” Science. AAAS, 2024. https://doi.org/10.1126/science.adp4663.
ieee: G. Novarino and C. Bock, “Mapping the brain’s gene-regulatory maze,” Science,
vol. 384, no. 6698. AAAS, pp. 860–861, 2024.
ista: Novarino G, Bock C. 2024. Mapping the brain’s gene-regulatory maze. Science.
384(6698), 860–861.
mla: Novarino, Gaia, and Christoph Bock. “Mapping the Brain’s Gene-Regulatory Maze.”
Science, vol. 384, no. 6698, AAAS, 2024, pp. 860–61, doi:10.1126/science.adp4663.
short: G. Novarino, C. Bock, Science 384 (2024) 860–861.
corr_author: '1'
das_tickbox: '0'
date_created: 2024-06-02T22:00:57Z
date_published: 2024-05-24T00:00:00Z
date_updated: 2026-10-02T09:50:30Z
day: '24'
department:
- _id: GaNo
doi: 10.1126/science.adp4663
external_id:
isi:
- '001230076500007'
pmid:
- '38781359'
fulldoi: https://doi.org/10.1126/science.adp4663
intvolume: ' 384'
isi: 1
issue: '6698'
language:
- iso: eng
month: '05'
oa_version: None
page: 860-861
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Mapping the brain’s gene-regulatory maze
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 384
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '15251'
abstract:
- lang: eng
text: Brassinosteroids are steroidal phytohormones that regulate plant development
and physiology, including adaptation to environmental stresses. Brassinosteroids
are synthesized in the cell interior but bind receptors at the cell surface, necessitating
a yet to be identified export mechanism. Here, we show that a member of the ATP-binding
cassette (ABC) transporter superfamily, ABCB19, functions as a brassinosteroid
exporter. We present its structure in both the substrate-unbound and the brassinosteroid-bound
states. Bioactive brassinosteroids are potent activators of ABCB19 ATP hydrolysis
activity, and transport assays showed that ABCB19 transports brassinosteroids.
In Arabidopsis thaliana, ABCB19 and its close homolog, ABCB1, positively regulate
brassinosteroid responses. Our results uncover an elusive export mechanism for
bioactive brassinosteroids that is tightly coordinated with brassinosteroid signaling.
acknowledgement: "We thank the Cryo-EM Center of the University of Science and Technology
of China for the EM facility support, Y. Yin (Iowa State University, Ames, IA, USA)
for providing the anti-BES1 antibody, Y. Gao and all other staff members for their
technical support on cryo-EM data collection, S. Vanneste (VIB, Ghent University,
Ghent, Belgium) for useful discussions, and M. De Cock for help in preparing the
manuscript.\r\nThis work was supported by the National Natural Science Foundation
of China (grants 31870732 and 32322041 to L.S., grant 31900885 to X.L., and grant
32321001 to L.S.); the Strategic Priority Research Program of the Chinese Academy
of Sciences (grant XDB37020103 to L.S.); the Natural Science Foundation of Anhui
Province (grant 2008085MC90 to X.L. and grant 2008085J15 to L.S.); Fundamental Research
Funds for the Central Universities (grant WK9100000031 to L.S.); USTC Research Funds
of the Double First-Class Initiative (grant YD9100002004 to L.S. and grant YD9100002020
to X.L.); Research Foundation-Flanders (grant G002121N to E.R. and postdoctoral
fellowships 12R7822N and 12R7819N to N.V.); and Chinese Scholarship Council predoctoral
fellowships (Y.W. and H.Z.). L.S. is supported by an Outstanding Young Scholar Award
from the Qiu Shi Science and Technologies Foundation and a Young Scholar Award from
the Cyrus Tang Foundation."
article_processing_charge: No
article_type: original
author:
- first_name: Wei
full_name: Ying, Wei
last_name: Ying
- first_name: Yaowei
full_name: Wang, Yaowei
last_name: Wang
- first_name: Hong
full_name: Wei, Hong
last_name: Wei
- first_name: Yongming
full_name: Luo, Yongming
last_name: Luo
- first_name: Qian
full_name: Ma, Qian
last_name: Ma
- first_name: Heyuan
full_name: Zhu, Heyuan
last_name: Zhu
- first_name: Hilde
full_name: Janssens, Hilde
last_name: Janssens
- first_name: Nemanja
full_name: Vukašinović, Nemanja
last_name: Vukašinović
- first_name: Miroslav
full_name: Kvasnica, Miroslav
last_name: Kvasnica
- first_name: Johan M.
full_name: Winne, Johan M.
last_name: Winne
- first_name: Yongxiang
full_name: Gao, Yongxiang
last_name: Gao
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Xin
full_name: Liu, Xin
last_name: Liu
- first_name: Eugenia
full_name: Russinova, Eugenia
last_name: Russinova
- first_name: Linfeng
full_name: Sun, Linfeng
last_name: Sun
citation:
ama: Ying W, Wang Y, Wei H, et al. Structure and function of the Arabidopsis ABC
transporter ABCB19 in brassinosteroid export. Science. 2024;383(6689):eadj4591.
doi:10.1126/science.adj4591
apa: Ying, W., Wang, Y., Wei, H., Luo, Y., Ma, Q., Zhu, H., … Sun, L. (2024). Structure
and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export.
Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.adj4591
chicago: Ying, Wei, Yaowei Wang, Hong Wei, Yongming Luo, Qian Ma, Heyuan Zhu, Hilde
Janssens, et al. “Structure and Function of the Arabidopsis ABC Transporter ABCB19
in Brassinosteroid Export.” Science. American Association for the Advancement
of Science, 2024. https://doi.org/10.1126/science.adj4591.
ieee: W. Ying et al., “Structure and function of the Arabidopsis ABC transporter
ABCB19 in brassinosteroid export,” Science, vol. 383, no. 6689. American
Association for the Advancement of Science, p. eadj4591, 2024.
ista: Ying W, Wang Y, Wei H, Luo Y, Ma Q, Zhu H, Janssens H, Vukašinović N, Kvasnica
M, Winne JM, Gao Y, Tan S, Friml J, Liu X, Russinova E, Sun L. 2024. Structure
and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export.
Science. 383(6689), eadj4591.
mla: Ying, Wei, et al. “Structure and Function of the Arabidopsis ABC Transporter
ABCB19 in Brassinosteroid Export.” Science, vol. 383, no. 6689, American
Association for the Advancement of Science, 2024, p. eadj4591, doi:10.1126/science.adj4591.
short: W. Ying, Y. Wang, H. Wei, Y. Luo, Q. Ma, H. Zhu, H. Janssens, N. Vukašinović,
M. Kvasnica, J.M. Winne, Y. Gao, S. Tan, J. Friml, X. Liu, E. Russinova, L. Sun,
Science 383 (2024) eadj4591.
das_tickbox: '1'
dataavailabilitystatement: All data are available in the main text or the supplementary
materials. Model coordinates and cryo-EM density maps for the WT ABCB19 structures
in the substrate-unbound state, BL-bound state, BL and AMP-PNP-bound state, and
the E529Q/E1174Q mutant ABCB19 structure in the ATP-bound state have been deposited
in the Protein Data Bank with accession codes 8WOI, 8WOM, 8WOO, and 8WP0, respectively,
and in the Electron Microscopy Data Bank with accession codes EMD-37690, EMD-37692,
EMD-37694, and EMD-37705, respectively.
date_created: 2024-03-31T22:01:12Z
date_published: 2024-03-22T00:00:00Z
date_updated: 2026-10-15T08:08:30Z
day: '22'
department:
- _id: JiFr
doi: 10.1126/science.adj4591
external_id:
isi:
- '001252955200028'
pmid:
- '38513023'
fulldoi: https://doi.org/10.1126/science.adj4591
intvolume: ' 383'
isi: 1
issue: '6689'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://hdl.handle.net/1854/LU-01HTMBK3P3PPNB73YFCMFXP3ZZ
month: '03'
oa: 1
oa_version: Submitted Version
page: eadj4591
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid
export
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 383
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '17090'
abstract:
- lang: eng
text: Primordial neutral atomic gas, mostly composed of hydrogen, is the raw material
for star formation in galaxies. However, there are few direct constraints on the
amount of neutral atomic hydrogen (H i) in galaxies at early cosmic times. We
analyzed James Webb Space Telescope (JWST) near-infrared spectroscopy of distant
galaxies, at redshifts ≳8. From a sample of 12 galaxies, we identified three that
show strong damped Lyman-α absorption due to H i in their local surroundings.
The galaxies are located at spectroscopic redshifts of 8.8, 10.2, and 11.4, corresponding
to 400 to 600 million years after the Big Bang. They have H i column densities
≳1022 cm−2, which is an order of magnitude higher than expected for a fully neutral
intergalactic medium, and constitute a gas-rich population of young star-forming
galaxies.
acknowledgement: K.E.H. acknowledges support from Carlsberg Foundation Reintegration
Fellowship grant CF21-0103. A.H. acknowledges support from the VILLUM FONDEN under
grant 37459. C.A.M. acknowledges support from the VILLUM FONDEN under grant 37459
and the Carlsberg Foundation under grant CF22-1322. N.R.T. was funded through Science
and Technology Facilities Council (STFC) consolidated grant ST/W000857/1. R.P.N.
acknowledges funding from JWST programs GO-1933 and GO-2279. R.P.N. was supported
by the NASA Hubble Fellowship grant HST-HF2-51515.001-A awarded by the Space Telescope
Science Institute, which is operated by the Association of Universities for Research
in Astronomy under NASA contract NAS5-26555. P.A.O. received funding from the Swiss
State Secretariat for Education, Research, and Innovation (SERI) under contract
number MB22.00072 and from the Swiss National Science Foundation (SNSF) through
project grant 200020_207349.
article_processing_charge: No
article_type: original
author:
- first_name: Kasper E.
full_name: Heintz, Kasper E.
last_name: Heintz
- first_name: Darach
full_name: Watson, Darach
last_name: Watson
- first_name: Gabriel
full_name: Brammer, Gabriel
last_name: Brammer
- first_name: Simone
full_name: Vejlgaard, Simone
last_name: Vejlgaard
- first_name: Anne
full_name: Hutter, Anne
last_name: Hutter
- first_name: Victoria B.
full_name: Strait, Victoria B.
last_name: Strait
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Pascal A.
full_name: Oesch, Pascal A.
last_name: Oesch
- first_name: Páll
full_name: Jakobsson, Páll
last_name: Jakobsson
- first_name: Nial R.
full_name: Tanvir, Nial R.
last_name: Tanvir
- first_name: Peter
full_name: Laursen, Peter
last_name: Laursen
- first_name: Rohan P.
full_name: Naidu, Rohan P.
last_name: Naidu
- first_name: Charlotte A.
full_name: Mason, Charlotte A.
last_name: Mason
- first_name: Meghana
full_name: Killi, Meghana
last_name: Killi
- first_name: Intae
full_name: Jung, Intae
last_name: Jung
- first_name: Tiger Yu Yang
full_name: Hsiao, Tiger Yu Yang
last_name: Hsiao
- first_name: Unknown
full_name: Abdurro’Uf, Unknown
last_name: Abdurro’Uf
- first_name: Dan
full_name: Coe, Dan
last_name: Coe
- first_name: Pablo Arrabal
full_name: Haro, Pablo Arrabal
last_name: Haro
- first_name: Steven L.
full_name: Finkelstein, Steven L.
last_name: Finkelstein
- first_name: Sune
full_name: Toft, Sune
last_name: Toft
citation:
ama: Heintz KE, Watson D, Brammer G, et al. Strong damped Lyman-a absorption in
young star-forming galaxies at redshifts 9 to 11. Science. 2024;384(6698):890-894.
doi:10.1126/science.adj0343
apa: Heintz, K. E., Watson, D., Brammer, G., Vejlgaard, S., Hutter, A., Strait,
V. B., … Toft, S. (2024). Strong damped Lyman-a absorption in young star-forming
galaxies at redshifts 9 to 11. Science. AAAS. https://doi.org/10.1126/science.adj0343
chicago: Heintz, Kasper E., Darach Watson, Gabriel Brammer, Simone Vejlgaard, Anne
Hutter, Victoria B. Strait, Jorryt J Matthee, et al. “Strong Damped Lyman-a Absorption
in Young Star-Forming Galaxies at Redshifts 9 to 11.” Science. AAAS, 2024.
https://doi.org/10.1126/science.adj0343.
ieee: K. E. Heintz et al., “Strong damped Lyman-a absorption in young star-forming
galaxies at redshifts 9 to 11,” Science, vol. 384, no. 6698. AAAS, pp.
890–894, 2024.
ista: Heintz KE, Watson D, Brammer G, Vejlgaard S, Hutter A, Strait VB, Matthee
JJ, Oesch PA, Jakobsson P, Tanvir NR, Laursen P, Naidu RP, Mason CA, Killi M,
Jung I, Hsiao TYY, Abdurro’Uf U, Coe D, Haro PA, Finkelstein SL, Toft S. 2024.
Strong damped Lyman-a absorption in young star-forming galaxies at redshifts 9
to 11. Science. 384(6698), 890–894.
mla: Heintz, Kasper E., et al. “Strong Damped Lyman-a Absorption in Young Star-Forming
Galaxies at Redshifts 9 to 11.” Science, vol. 384, no. 6698, AAAS, 2024,
pp. 890–94, doi:10.1126/science.adj0343.
short: K.E. Heintz, D. Watson, G. Brammer, S. Vejlgaard, A. Hutter, V.B. Strait,
J.J. Matthee, P.A. Oesch, P. Jakobsson, N.R. Tanvir, P. Laursen, R.P. Naidu, C.A.
Mason, M. Killi, I. Jung, T.Y.Y. Hsiao, U. Abdurro’Uf, D. Coe, P.A. Haro, S.L.
Finkelstein, S. Toft, Science 384 (2024) 890–894.
das_tickbox: '1'
dataavailabilitystatement: 'The JWST spectroscopic data are available at the Mikulski
Archive for Space Telescopes (MAST) (https://mast.stsci.edu) under program IDs DD-2750
and GO-1433 for the three selected galaxies; the IDs for the other galaxies we searched
are listed in table S1. Our data analysis codes are archived at Zenodo (19, 20).
The reduced spectroscopic data are available through the DAWN JWST Archive (DJA):
https://s3.amazonaws.com/msaexp-nirspec/extractions/nirspec_graded.html under file
names ceers-ddt-v1_prism-clear_2750_28.spec.fits for CEERS-43833, macsj0647-v1_prism-clear_1433_3593.spec.fits
for MACS0647-JD, and ceers-ddt-v1_prism-clear_2750_1.spec.fits for CEERS-16943.
The photometry is available at https://dawn-cph.github.io/dja/imaging/v7/. Our derived
physical parameters are provided in Table 1, and measured line fluxes are provided
in table S2.'
date_created: 2024-06-02T22:00:56Z
date_published: 2024-05-24T00:00:00Z
date_updated: 2026-10-15T09:10:20Z
day: '24'
department:
- _id: JoMa
doi: 10.1126/science.adj0343
external_id:
isi:
- '001230029500001'
pmid:
- '38781391'
fulldoi: https://doi.org/10.1126/science.adj0343
intvolume: ' 384'
isi: 1
issue: '6698'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://figshare.com/articles/journal_contribution/Strong_damped_Lyman-_absorption_in_young_star-forming_galaxies_at_redshifts_9_to_11/26069122?file=47174584
month: '05'
oa: 1
oa_version: Submitted Version
page: 890-894
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Strong damped Lyman-a absorption in young star-forming galaxies at redshifts
9 to 11
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 384
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '15316'
abstract:
- lang: eng
text: Genomic DNA that resides in the nuclei of mammalian neurons can be as old
as the organism itself. The life span of nuclear RNAs, which are critical for
proper chromatin architecture and transcription regulation, has not been determined
in adult tissues. In this work, we identified and characterized nuclear RNAs that
do not turn over for at least 2 years in a subset of postnatally born cells in
the mouse brain. These long-lived RNAs were stably retained in nuclei in a neural
cell type–specific manner and were required for the maintenance of heterochromatin.
Thus, the life span of neural cells may depend on both the molecular longevity
of DNA for the storage of genetic information and also the extreme stability of
RNA for the functional organization of chromatin.
acknowledgement: 'European Research Council: ERC-2018-STG, 804468 EAGER; European
Research Council: ERC-2023-COG, 101125034 NEUTIME; Deutsche Forschungsgemeinschaft:
TO1347/4-1; Boehringer Ingelheim Stiftung; Deutsches Zentrum für Neurodegenerative
Erkrankungen'
article_processing_charge: No
article_type: original
author:
- first_name: Sara
full_name: Zocher, Sara
last_name: Zocher
- first_name: Asako
full_name: Mccloskey, Asako
last_name: Mccloskey
- first_name: Anne
full_name: Karasinsky, Anne
last_name: Karasinsky
- first_name: Roberta
full_name: Schulte, Roberta
last_name: Schulte
- first_name: Ulrike
full_name: Friedrich, Ulrike
last_name: Friedrich
- first_name: Mathias
full_name: Lesche, Mathias
last_name: Lesche
- first_name: Nicole
full_name: Rund, Nicole
last_name: Rund
- first_name: Fred H.
full_name: Gage, Fred H.
last_name: Gage
- first_name: Martin W
full_name: Hetzer, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: Hetzer
orcid: 0000-0002-2111-992X
- first_name: Tomohisa
full_name: Toda, Tomohisa
last_name: Toda
citation:
ama: Zocher S, Mccloskey A, Karasinsky A, et al. Lifelong persistence of nuclear
RNAs in the mouse brain. Science. 2024;384(6691):53-59. doi:10.1126/science.adf3481
apa: Zocher, S., Mccloskey, A., Karasinsky, A., Schulte, R., Friedrich, U., Lesche,
M., … Toda, T. (2024). Lifelong persistence of nuclear RNAs in the mouse brain.
Science. AAAS. https://doi.org/10.1126/science.adf3481
chicago: Zocher, Sara, Asako Mccloskey, Anne Karasinsky, Roberta Schulte, Ulrike
Friedrich, Mathias Lesche, Nicole Rund, Fred H. Gage, Martin Hetzer, and Tomohisa
Toda. “Lifelong Persistence of Nuclear RNAs in the Mouse Brain.” Science.
AAAS, 2024. https://doi.org/10.1126/science.adf3481.
ieee: S. Zocher et al., “Lifelong persistence of nuclear RNAs in the mouse
brain,” Science, vol. 384, no. 6691. AAAS, pp. 53–59, 2024.
ista: Zocher S, Mccloskey A, Karasinsky A, Schulte R, Friedrich U, Lesche M, Rund
N, Gage FH, Hetzer M, Toda T. 2024. Lifelong persistence of nuclear RNAs in the
mouse brain. Science. 384(6691), 53–59.
mla: Zocher, Sara, et al. “Lifelong Persistence of Nuclear RNAs in the Mouse Brain.”
Science, vol. 384, no. 6691, AAAS, 2024, pp. 53–59, doi:10.1126/science.adf3481.
short: S. Zocher, A. Mccloskey, A. Karasinsky, R. Schulte, U. Friedrich, M. Lesche,
N. Rund, F.H. Gage, M. Hetzer, T. Toda, Science 384 (2024) 53–59.
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: All data are available in the main text, figures, or supplementary
materials. EU-RNA-seq data were submitted to the Gene Expression Omnibus (GEO) under
accession no. GSE248101.
date_created: 2024-04-14T22:01:01Z
date_published: 2024-04-04T00:00:00Z
date_updated: 2026-10-16T08:59:32Z
day: '04'
department:
- _id: MaHe
doi: 10.1126/science.adf3481
external_id:
isi:
- '001253335100031'
pmid:
- '38574132'
fulldoi: https://doi.org/10.1126/science.adf3481
intvolume: ' 384'
isi: 1
issue: '6691'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615865
month: '04'
oa: 1
oa_version: Submitted Version
page: 53-59
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/nerve-cells-old-at-heart/
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Lifelong persistence of nuclear RNAs in the mouse brain
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 384
year: '2024'
...
---
_id: '15166'
abstract:
- lang: eng
text: Reducing defects boosts room-temperature performance of a thermoelectric device
acknowledgement: The authors thank the Werner-Siemens-Stiftung and the Institute of
Science and Technology Austria for financial support.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Navita
full_name: Navita, Navita
id: 6ebe278d-ba0b-11ee-8184-f34cdc671de4
last_name: Navita
orcid: 0000-0001-7408-8197
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
citation:
ama: Jakhar N, Ibáñez M. Electron highways are cooler. Science. 2024;383(6688):1184.
doi:10.1126/science.ado4077
apa: Jakhar, N., & Ibáñez, M. (2024). Electron highways are cooler. Science.
American Association for the Advancement of Science. https://doi.org/10.1126/science.ado4077
chicago: Jakhar, Navita, and Maria Ibáñez. “Electron Highways Are Cooler.” Science.
American Association for the Advancement of Science, 2024. https://doi.org/10.1126/science.ado4077.
ieee: N. Jakhar and M. Ibáñez, “Electron highways are cooler,” Science, vol.
383, no. 6688. American Association for the Advancement of Science, p. 1184, 2024.
ista: Jakhar N, Ibáñez M. 2024. Electron highways are cooler. Science. 383(6688),
1184.
mla: Jakhar, Navita, and Maria Ibáñez. “Electron Highways Are Cooler.” Science,
vol. 383, no. 6688, American Association for the Advancement of Science, 2024,
p. 1184, doi:10.1126/science.ado4077.
short: N. Jakhar, M. Ibáñez, Science 383 (2024) 1184.
corr_author: '1'
das_tickbox: '0'
date_created: 2024-03-24T23:00:58Z
date_published: 2024-03-14T00:00:00Z
date_updated: 2026-10-16T09:20:57Z
day: '14'
department:
- _id: MaIb
doi: 10.1126/science.ado4077
external_id:
isi:
- '001273082800019'
pmid:
- '38484066'
fulldoi: https://doi.org/10.1126/science.ado4077
intvolume: ' 383'
isi: 1
issue: '6688'
language:
- iso: eng
month: '03'
oa_version: None
page: '1184'
pmid: 1
project:
- _id: 9B8F7476-BA93-11EA-9121-9846C619BF3A
name: 'HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of
Semiconductors for Waste Heat Recovery'
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Electron highways are cooler
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 383
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '14796'
abstract:
- lang: eng
text: Key innovations are fundamental to biological diversification, but their genetic
basis is poorly understood. A recent transition from egg-laying to live-bearing
in marine snails (Littorina spp.) provides the opportunity to study the genetic
architecture of an innovation that has evolved repeatedly across animals. Individuals
do not cluster by reproductive mode in a genome-wide phylogeny, but local genealogical
analysis revealed numerous small genomic regions where all live-bearers carry
the same core haplotype. Candidate regions show evidence for live-bearer–specific
positive selection and are enriched for genes that are differentially expressed
between egg-laying and live-bearing reproductive systems. Ages of selective sweeps
suggest that live-bearer–specific alleles accumulated over more than 200,000 generations.
Our results suggest that new functions evolve through the recruitment of many
alleles rather than in a single evolutionary step.
acknowledgement: "We thank J. Galindo, M. Montaño-Rendón, N. Mikhailova, A. Blakeslee,
E. Arnason, and P. Kemppainen for providing samples; R. Turney, G. Sotelo, J. Larsson,
T. Broquet, and S. Loisel for help collecting samples; Science Animated for providing
the snail cartoons shown in Fig. 1; M. Dunning for help in developing bioinformatic
pipelines; R. Faria, H. Morales, and V. Sousa for advice; and M. Hahn, J. Slate,
M. Ravinet, J. Raeymaekers, A. Comeault, and N. Barton for feedback on a draft manuscript.\r\nThis
work was supported by the Natural Environment Research Council (grant NE/P001610/1
to R.K.B.), the European Research Council (grant ERC-2015-AdG693030-BARRIERS to
R.K.B.), the Norwegian Research Council (RCN Project 315287 to A.M.W.), and the
Swedish Research Council (grant 2020-05385 to E.L.)."
article_processing_charge: No
article_type: original
author:
- first_name: Sean
full_name: Stankowski, Sean
id: 43161670-5719-11EA-8025-FABC3DDC885E
last_name: Stankowski
- first_name: Zuzanna B.
full_name: Zagrodzka, Zuzanna B.
last_name: Zagrodzka
- first_name: Martin D.
full_name: Garlovsky, Martin D.
last_name: Garlovsky
- first_name: Arka
full_name: Pal, Arka
id: 6AAB2240-CA9A-11E9-9C1A-D9D1E5697425
last_name: Pal
orcid: 0000-0002-4530-8469
- first_name: Daria
full_name: Shipilina, Daria
id: 428A94B0-F248-11E8-B48F-1D18A9856A87
last_name: Shipilina
orcid: 0000-0002-1145-9226
- first_name: Diego Fernando
full_name: Garcia Castillo, Diego Fernando
id: ae681a14-dc74-11ea-a0a7-c6ef18161701
last_name: Garcia Castillo
- first_name: Hila
full_name: Lifchitz, Hila
id: d6ab5470-2fb3-11ed-8633-986a9b84edac
last_name: Lifchitz
- first_name: Alan
full_name: Le Moan, Alan
last_name: Le Moan
- first_name: Erica
full_name: Leder, Erica
last_name: Leder
- first_name: James
full_name: Reeve, James
last_name: Reeve
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Roger K.
full_name: Butlin, Roger K.
last_name: Butlin
citation:
ama: Stankowski S, Zagrodzka ZB, Garlovsky MD, et al. The genetic basis of a recent
transition to live-bearing in marine snails. Science. 2024;383(6678):114-119.
doi:10.1126/science.adi2982
apa: Stankowski, S., Zagrodzka, Z. B., Garlovsky, M. D., Pal, A., Shipilina, D.,
Garcia Castillo, D. F., … Butlin, R. K. (2024). The genetic basis of a recent
transition to live-bearing in marine snails. Science. American Association
for the Advancement of Science. https://doi.org/10.1126/science.adi2982
chicago: Stankowski, Sean, Zuzanna B. Zagrodzka, Martin D. Garlovsky, Arka Pal,
Daria Shipilina, Diego Fernando Garcia Castillo, Hila Lifchitz, et al. “The Genetic
Basis of a Recent Transition to Live-Bearing in Marine Snails.” Science.
American Association for the Advancement of Science, 2024. https://doi.org/10.1126/science.adi2982.
ieee: S. Stankowski et al., “The genetic basis of a recent transition to
live-bearing in marine snails,” Science, vol. 383, no. 6678. American Association
for the Advancement of Science, pp. 114–119, 2024.
ista: Stankowski S, Zagrodzka ZB, Garlovsky MD, Pal A, Shipilina D, Garcia Castillo
DF, Lifchitz H, Le Moan A, Leder E, Reeve J, Johannesson K, Westram AM, Butlin
RK. 2024. The genetic basis of a recent transition to live-bearing in marine snails.
Science. 383(6678), 114–119.
mla: Stankowski, Sean, et al. “The Genetic Basis of a Recent Transition to Live-Bearing
in Marine Snails.” Science, vol. 383, no. 6678, American Association for
the Advancement of Science, 2024, pp. 114–19, doi:10.1126/science.adi2982.
short: S. Stankowski, Z.B. Zagrodzka, M.D. Garlovsky, A. Pal, D. Shipilina, D.F.
Garcia Castillo, H. Lifchitz, A. Le Moan, E. Leder, J. Reeve, K. Johannesson,
A.M. Westram, R.K. Butlin, Science 383 (2024) 114–119.
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: Raw sequence data are available on the short-read archive
(SRA) under bioproject PRJNA626520. VCF files have been archived on Zenodo (31).
All analysis scripts have been archived on Zenodo (31) and are available on Github
at https://github.com/seanstankowski/Littorina_reproductive_mode.
date_created: 2024-01-14T23:00:56Z
date_published: 2024-01-05T00:00:00Z
date_updated: 2026-11-07T23:31:14Z
day: '05'
department:
- _id: NiBa
- _id: GradSch
doi: 10.1126/science.adi2982
external_id:
isi:
- '001138156400003'
pmid:
- '38175895'
fulldoi: https://doi.org/10.1126/science.adi2982
intvolume: ' 383'
isi: 1
issue: '6678'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://figshare.com/articles/journal_contribution/The_genetic_basis_of_a_recent_transition_to_live-bearing_in_marine_snails/26356054?file=47868241
month: '01'
oa: 1
oa_version: Submitted Version
page: 114-119
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
related_material:
link:
- description: News on ISTA Website
relation: press_release
url: https://ista.ac.at/en/news/the-snail-or-the-egg/
record:
- id: '14812'
relation: research_data
status: public
- id: '20694'
relation: dissertation_contains
status: public
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: The genetic basis of a recent transition to live-bearing in marine snails
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 383
year: '2024'
...