---
OA_type: closed access
_id: '2627'
abstract:
- lang: eng
  text: Despite its implications for higher order functions of the brain, little is
    currently known about the molecular basis of left-right asymmetry of the brain.
    Here we report that synaptic distribution of N-methyl-D-aspartate (NMDA) receptor
    GluRε2 (NR2B) subunits in the adult mouse hippocampus is asymmetrical between
    the left and right and between the apical and basal dendrites of single neurons.
    These asymmetrical allocations of ε2 subunits differentiate the properties of
    NMDA receptors and synaptic plasticity between the left and right hippocampus.
    These results provide a molecular basis for the structural and functional asymmetry
    of the mature brain.
article_processing_charge: No
author:
- first_name: Ryosuke
  full_name: Kawakami, Ryosuke
  last_name: Kawakami
- first_name: Yoshiaki
  full_name: Shinohara, Yoshiaki
  last_name: Shinohara
- first_name: Yuichiro
  full_name: Kato, Yuichiro
  last_name: Kato
- first_name: Hiroyuki
  full_name: Sugiyama, Hiroyuki
  last_name: Sugiyama
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Isao
  full_name: Ito, Isao
  last_name: Ito
citation:
  ama: Kawakami R, Shinohara Y, Kato Y, Sugiyama H, Shigemoto R, Ito I. <i>Asymmetrical
    Allocation of NMDA Receptor Ε2 Subunits in Hippocampal Circuitry</i>. Vol 300.
    American Association for the Advancement of Science; 2003:990-994. doi:<a href="https://doi.org/10.1126/science.1082609">10.1126/science.1082609</a>
  apa: Kawakami, R., Shinohara, Y., Kato, Y., Sugiyama, H., Shigemoto, R., &#38; Ito,
    I. (2003). <i>Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal
    circuitry</i> (Vol. 300, pp. 990–994). American Association for the Advancement
    of Science. <a href="https://doi.org/10.1126/science.1082609">https://doi.org/10.1126/science.1082609</a>
  chicago: Kawakami, Ryosuke, Yoshiaki Shinohara, Yuichiro Kato, Hiroyuki Sugiyama,
    Ryuichi Shigemoto, and Isao Ito. <i>Asymmetrical Allocation of NMDA Receptor Ε2
    Subunits in Hippocampal Circuitry</i>. Vol. 300. American Association for the
    Advancement of Science, 2003. <a href="https://doi.org/10.1126/science.1082609">https://doi.org/10.1126/science.1082609</a>.
  ieee: R. Kawakami, Y. Shinohara, Y. Kato, H. Sugiyama, R. Shigemoto, and I. Ito,
    <i>Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry</i>,
    vol. 300. American Association for the Advancement of Science, 2003, pp. 990–994.
  ista: Kawakami R, Shinohara Y, Kato Y, Sugiyama H, Shigemoto R, Ito I. 2003. Asymmetrical
    allocation of NMDA receptor ε2 subunits in hippocampal circuitry, American Association
    for the Advancement of Science,p.
  mla: Kawakami, Ryosuke, et al. <i>Asymmetrical Allocation of NMDA Receptor Ε2 Subunits
    in Hippocampal Circuitry</i>. Vol. 300, American Association for the Advancement
    of Science, 2003, pp. 990–94, doi:<a href="https://doi.org/10.1126/science.1082609">10.1126/science.1082609</a>.
  short: R. Kawakami, Y. Shinohara, Y. Kato, H. Sugiyama, R. Shigemoto, I. Ito, Asymmetrical
    Allocation of NMDA Receptor Ε2 Subunits in Hippocampal Circuitry, American Association
    for the Advancement of Science, 2003.
date_created: 2018-12-11T11:58:45Z
date_published: 2003-05-09T00:00:00Z
date_updated: 2026-05-22T11:42:53Z
day: '09'
doi: 10.1126/science.1082609
extern: '1'
external_id:
  pmid:
  - '12738868'
fulldoi: https://doi.org/10.1126/science.1082609
intvolume: '       300'
language:
- iso: eng
month: '05'
oa_version: None
page: 990 - 994
pmid: 1
publication_identifier:
  eissn:
  - 1095-9203
  issn:
  - 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '4271'
scopus_import: '1'
status: public
title: Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry
type: report
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 300
year: '2003'
...
---
_id: '9455'
abstract:
- lang: eng
  text: Proteins of the ARGONAUTE family are important in diverse posttranscriptional
    RNA-mediated gene-silencing systems as well as in transcriptional gene silencing
    in Drosophila and fission yeast and in programmed DNA elimination in Tetrahymena.
    We cloned ARGONAUTE4 (AGO4) from a screen for mutants that suppress silencing
    of the Arabidopsis SUPERMAN(SUP) gene. The ago4-1 mutant reactivated silentSUP
    alleles and decreased CpNpG and asymmetric DNA methylation as well as histone
    H3 lysine-9 methylation. In addition,ago4-1 blocked histone and DNA methylation
    and the accumulation of 25-nucleotide small interfering RNAs (siRNAs) that correspond
    to the retroelement AtSN1. These results suggest that AGO4 and long siRNAs direct
    chromatin modifications, including histone methylation and non-CpG DNA methylation.
article_processing_charge: No
article_type: original
author:
- first_name: Daniel
  full_name: Zilberman, Daniel
  id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
  last_name: Zilberman
  orcid: 0000-0002-0123-8649
- first_name: ' Xiaofeng'
  full_name: Cao,  Xiaofeng
  last_name: Cao
- first_name: Steven E.
  full_name: Jacobsen, Steven E.
  last_name: Jacobsen
citation:
  ama: Zilberman D, Cao  Xiaofeng, Jacobsen SE. ARGONAUTE4 control of locus-specific
    siRNA accumulation and DNA and histone methylation. <i>Science</i>. 2003;299(5607):716-719.
    doi:<a href="https://doi.org/10.1126/science.1079695">10.1126/science.1079695</a>
  apa: Zilberman, D., Cao,  Xiaofeng, &#38; Jacobsen, S. E. (2003). ARGONAUTE4 control
    of locus-specific siRNA accumulation and DNA and histone methylation. <i>Science</i>.
    American Association for the Advancement of Science. <a href="https://doi.org/10.1126/science.1079695">https://doi.org/10.1126/science.1079695</a>
  chicago: Zilberman, Daniel,  Xiaofeng Cao, and Steven E. Jacobsen. “ARGONAUTE4 Control
    of Locus-Specific SiRNA Accumulation and DNA and Histone Methylation.” <i>Science</i>.
    American Association for the Advancement of Science, 2003. <a href="https://doi.org/10.1126/science.1079695">https://doi.org/10.1126/science.1079695</a>.
  ieee: D. Zilberman,  Xiaofeng Cao, and S. E. Jacobsen, “ARGONAUTE4 control of locus-specific
    siRNA accumulation and DNA and histone methylation,” <i>Science</i>, vol. 299,
    no. 5607. American Association for the Advancement of Science, pp. 716–719, 2003.
  ista: Zilberman D, Cao  Xiaofeng, Jacobsen SE. 2003. ARGONAUTE4 control of locus-specific
    siRNA accumulation and DNA and histone methylation. Science. 299(5607), 716–719.
  mla: Zilberman, Daniel, et al. “ARGONAUTE4 Control of Locus-Specific SiRNA Accumulation
    and DNA and Histone Methylation.” <i>Science</i>, vol. 299, no. 5607, American
    Association for the Advancement of Science, 2003, pp. 716–19, doi:<a href="https://doi.org/10.1126/science.1079695">10.1126/science.1079695</a>.
  short: D. Zilberman,  Xiaofeng Cao, S.E. Jacobsen, Science 299 (2003) 716–719.
date_created: 2021-06-04T11:26:26Z
date_published: 2003-01-31T00:00:00Z
date_updated: 2021-12-14T08:43:30Z
day: '31'
department:
- _id: DaZi
doi: 10.1126/science.1079695
extern: '1'
external_id:
  pmid:
  - '12522258'
fulldoi: https://doi.org/10.1126/science.1079695
intvolume: '       299'
issue: '5607'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '01'
oa_version: None
page: 716-719
pmid: 1
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
  issn:
  - 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone
  methylation
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 299
year: '2003'
...
---
_id: '9444'
abstract:
- lang: eng
  text: Epigenetic silenced alleles of the Arabidopsis SUPERMANlocus (the clark kent
    alleles) are associated with dense hypermethylation at noncanonical cytosines
    (CpXpG and asymmetric sites, where X = A, T, C, or G). A genetic screen for suppressors
    of a hypermethylated clark kent mutant identified nine loss-of-function alleles
    of CHROMOMETHYLASE3(CMT3), a novel cytosine methyltransferase homolog. These cmt3
    mutants display a wild-type morphology but exhibit decreased CpXpG methylation
    of the SUP gene and of other sequences throughout the genome. They also show reactivated
    expression of endogenous retrotransposon sequences. These results show that a
    non-CpG DNA methyltransferase is responsible for maintaining epigenetic gene silencing.
article_processing_charge: No
article_type: original
author:
- first_name: A. M.
  full_name: Lindroth, A. M.
  last_name: Lindroth
- first_name: Xiaofeng
  full_name: Cao, Xiaofeng
  last_name: Cao
- first_name: James P.
  full_name: Jackson, James P.
  last_name: Jackson
- first_name: Daniel
  full_name: Zilberman, Daniel
  id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
  last_name: Zilberman
  orcid: 0000-0002-0123-8649
- first_name: Claire M.
  full_name: McCallum, Claire M.
  last_name: McCallum
- first_name: Steven
  full_name: Henikoff, Steven
  last_name: Henikoff
- first_name: Steven E.
  full_name: Jacobsen, Steven E.
  last_name: Jacobsen
citation:
  ama: Lindroth AM, Cao X, Jackson JP, et al. Requirement of CHROMOMETHYLASE3 for
    maintenance of CpXpG methylation. <i>Science</i>. 2001;292(5524):2077-2080. doi:<a
    href="https://doi.org/10.1126/science.1059745">10.1126/science.1059745</a>
  apa: Lindroth, A. M., Cao, X., Jackson, J. P., Zilberman, D., McCallum, C. M., Henikoff,
    S., &#38; Jacobsen, S. E. (2001). Requirement of CHROMOMETHYLASE3 for maintenance
    of CpXpG methylation. <i>Science</i>. American Association for the Advancement
    of Science. <a href="https://doi.org/10.1126/science.1059745">https://doi.org/10.1126/science.1059745</a>
  chicago: Lindroth, A. M., Xiaofeng Cao, James P. Jackson, Daniel Zilberman, Claire
    M. McCallum, Steven Henikoff, and Steven E. Jacobsen. “Requirement of CHROMOMETHYLASE3
    for Maintenance of CpXpG Methylation.” <i>Science</i>. American Association for
    the Advancement of Science, 2001. <a href="https://doi.org/10.1126/science.1059745">https://doi.org/10.1126/science.1059745</a>.
  ieee: A. M. Lindroth <i>et al.</i>, “Requirement of CHROMOMETHYLASE3 for maintenance
    of CpXpG methylation,” <i>Science</i>, vol. 292, no. 5524. American Association
    for the Advancement of Science, pp. 2077–2080, 2001.
  ista: Lindroth AM, Cao X, Jackson JP, Zilberman D, McCallum CM, Henikoff S, Jacobsen
    SE. 2001. Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation.
    Science. 292(5524), 2077–2080.
  mla: Lindroth, A. M., et al. “Requirement of CHROMOMETHYLASE3 for Maintenance of
    CpXpG Methylation.” <i>Science</i>, vol. 292, no. 5524, American Association for
    the Advancement of Science, 2001, pp. 2077–80, doi:<a href="https://doi.org/10.1126/science.1059745">10.1126/science.1059745</a>.
  short: A.M. Lindroth, X. Cao, J.P. Jackson, D. Zilberman, C.M. McCallum, S. Henikoff,
    S.E. Jacobsen, Science 292 (2001) 2077–2080.
date_created: 2021-06-02T13:35:16Z
date_published: 2001-06-15T00:00:00Z
date_updated: 2021-12-14T08:40:32Z
day: '15'
department:
- _id: DaZi
doi: 10.1126/science.1059745
extern: '1'
external_id:
  pmid:
  - '11349138'
fulldoi: https://doi.org/10.1126/science.1059745
intvolume: '       292'
issue: '5524'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '06'
oa_version: None
page: 2077-2080
pmid: 1
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
  issn:
  - 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 292
year: '2001'
...