---
OA_place: repository
OA_type: green
_id: '23003'
abstract:
- lang: eng
text: The peripheral neural pathways that relay oral and post-ingestive chemo- and
mechanosensory signals to the brain during food consumption are increasingly well
understood. Far less is known about how these and other body signals are integrated
and organized in the brainstem lateral parabrachial nucleus (LPBN), a key interoceptive
sensory hub. We established methods for dense calcium imaging of 100s of neurons
from mouse LPBN. Food consumption drove a seconds-long wave of activity across
LPBN, with dynamics mirroring the movement of food through the upper gastrointestinal
tract as observed using X-ray videofluoroscopy. By imaging the same neurons across
days, we found that spatially clustered subsets of neurons encoded oral signals,
stomach filling, visceral malaise, arousal, and/or body movement. Moreover, only
certain subsets were modulated by cortical input. Together, these experiments
establish a platform for understanding how peripheral and central interoceptive
signals are integrated in the brainstem to guide behavior.
acknowledgement: We thank S. Zhang, K. Evans, C. Massengill, J.S. Alvarado, and members
of the Andermann lab for helpful discussion and feedback. We thank J. Mathai for
the use of the LabScope for fluoroscopy experiments. We thank J. Fernando, P. Prasad,
D. Guarino, J. DeBolt, Z. Stolberg, and A. Pinilla for animal husbandry and other
technical assistance. Authors were supported by NSF GRFP DGE1745303, NIH F31DC020631,
and NIH T32DK007516 (R.A.E.); NIH F32DK135247 and NIH T32DK007516 (K.R.); the BBRF
Young Investigator Grant (H.K.); the Research Council of Norway Grant 250259 (S.G.
and K.K.L.); and the Pew Innovation Fund, the McKnight Foundation, the Klarman Family
Foundation, the Harvard Brain Science Initiative Bipolar Disorder Seed Grant supported
by Kent and Liz Dauten, the NIH (DP1AT010971, DP1DK139958, and P01HL149630), a gift
from Paul Weisman, and the K. Lisa Yang Brain-Body Center (M.L.A.).
article_processing_charge: No
article_type: original
author:
- first_name: Rachel A.
full_name: Essner, Rachel A.
last_name: Essner
- first_name: Kiersten
full_name: Ruda, Kiersten
last_name: Ruda
- first_name: Hannah J.
full_name: Choh, Hannah J.
last_name: Choh
- first_name: Hakan
full_name: Kücükdereli, Hakan
id: 5d5f6ea4-ef9e-11f0-a10a-85e12a3552af
last_name: Kücükdereli
- first_name: Oren
full_name: Amsalem, Oren
last_name: Amsalem
- first_name: Julia
full_name: Edelhaus, Julia
last_name: Edelhaus
- first_name: Gracesenia
full_name: Chahyadinata, Gracesenia
last_name: Chahyadinata
- first_name: Sverre
full_name: Grødem, Sverre
last_name: Grødem
- first_name: Kristian K.
full_name: Lensjø, Kristian K.
last_name: Lensjø
- first_name: Teresa E.
full_name: Lever, Teresa E.
last_name: Lever
- first_name: Mark L.
full_name: Andermann, Mark L.
last_name: Andermann
biorxivid: 1
citation:
ama: Essner RA, Ruda K, Choh HJ, et al. Brainstem sensing of multiple body signals
during food consumption. Neuron. 2026. doi:10.1016/j.neuron.2026.08.015
apa: Essner, R. A., Ruda, K., Choh, H. J., Kücükdereli, H., Amsalem, O., Edelhaus,
J., … Andermann, M. L. (2026). Brainstem sensing of multiple body signals during
food consumption. Neuron. Cell Press. https://doi.org/10.1016/j.neuron.2026.08.015
chicago: Essner, Rachel A., Kiersten Ruda, Hannah J. Choh, Hakan Kücükdereli, Oren
Amsalem, Julia Edelhaus, Gracesenia Chahyadinata, et al. “Brainstem Sensing of
Multiple Body Signals during Food Consumption.” Neuron. Cell Press, 2026.
https://doi.org/10.1016/j.neuron.2026.08.015.
ieee: R. A. Essner et al., “Brainstem sensing of multiple body signals during
food consumption,” Neuron. Cell Press, 2026.
ista: Essner RA, Ruda K, Choh HJ, Kücükdereli H, Amsalem O, Edelhaus J, Chahyadinata
G, Grødem S, Lensjø KK, Lever TE, Andermann ML. 2026. Brainstem sensing of multiple
body signals during food consumption. Neuron.
mla: Essner, Rachel A., et al. “Brainstem Sensing of Multiple Body Signals during
Food Consumption.” Neuron, Cell Press, 2026, doi:10.1016/j.neuron.2026.08.015.
short: R.A. Essner, K. Ruda, H.J. Choh, H. Kücükdereli, O. Amsalem, J. Edelhaus,
G. Chahyadinata, S. Grødem, K.K. Lensjø, T.E. Lever, M.L. Andermann, Neuron (2026).
das_tickbox: '1'
dataavailabilitystatement: "This study did not generate any new, unique reagents.Single-neuron
calcium imaging traces from all experiments have been deposited at Mendeley Data
at 10.17632/wh6f8xt64y.1 and are publicly available as of the date of publication.
Raw two-photon calcium imaging and fiber photometry datasets are available from
the lead contact upon request.\r\nAll original code is deposited on GitHub (https://github.com/kmruda/PBN_sensing_body_signals)
as well as Zenodo at 10.5281/zenodo.21926666 and is publicly available as of the
date of publication.\r\nAny additional information required to reanalyze the data
is available upon request from the lead contact, Mark L. Andermann (manderma@bidmc.harvard.edu)."
date_created: 2026-09-27T22:01:53Z
date_published: 2026-09-17T00:00:00Z
date_updated: 2026-10-07T08:40:54Z
day: '17'
department:
- _id: MaJö
doi: 10.1016/j.neuron.2026.08.015
external_id:
biorxivid:
- 10.1101/2025.04.28.651046
pmid:
- '42753729'
fulldoi: https://doi.org/10.1016/j.neuron.2026.08.015
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2025.04.28.651046
month: '09'
oa: 1
oa_version: Preprint
pmid: 1
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
issn:
- 0896-6273
publication_status: epub_ahead
publisher: Cell Press
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Brainstem sensing of multiple body signals during food consumption
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '19506'
abstract:
- lang: eng
text: 'Hippocampal reactivation of waking neuronal assemblies in sleep is a key
initial step of systems consolidation. Nevertheless, it is unclear whether reactivated
assemblies are static or whether they reorganize gradually over prolonged sleep.
We tracked reactivated CA1 assembly patterns over ∼20 h of sleep/rest periods
and related them to assemblies seen before or after in a spatial learning paradigm
using rats. We found that reactivated assembly patterns were gradually transformed
and started to resemble those seen in the subsequent recall session. Periods of
rapid eye movement (REM) sleep and non-REM (NREM) had antagonistic roles: whereas
NREM accelerated the assembly drift, REM countered it. Moreover, only a subset
of rate-changing pyramidal cells contributed to the drift, whereas stable-firing-rate
cells maintained unaltered reactivation patterns. Our data suggest that prolonged
sleep promotes the spontaneous reorganization of spatial assemblies, which can
contribute to daily cognitive map changes or encoding new learning situations.'
acknowledgement: We thank Andrea Cumpelik, Lisa Genzel, and Freya Ólafsdóttir for
comments on an earlier version of the manuscript. This work was supported by the
European Research Council (281511) and Austrian Science Fund (FWF I3713).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Lars
full_name: Bollmann, Lars
id: 47AD3038-F248-11E8-B48F-1D18A9856A87
last_name: Bollmann
- first_name: Peter
full_name: Baracskay, Peter
id: 361CC00E-F248-11E8-B48F-1D18A9856A87
last_name: Baracskay
- first_name: Federico
full_name: Stella, Federico
id: 39AF1E74-F248-11E8-B48F-1D18A9856A87
last_name: Stella
orcid: 0000-0001-9439-3148
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Bollmann L, Baracskay P, Stella F, Csicsvari JL. Sleep stages antagonistically
modulate reactivation drift. Neuron. 2025;113(9):1446-1459.e6. doi:10.1016/j.neuron.2025.02.025
apa: Bollmann, L., Baracskay, P., Stella, F., & Csicsvari, J. L. (2025). Sleep
stages antagonistically modulate reactivation drift. Neuron. Cell Press.
https://doi.org/10.1016/j.neuron.2025.02.025
chicago: Bollmann, Lars, Peter Baracskay, Federico Stella, and Jozsef L Csicsvari.
“Sleep Stages Antagonistically Modulate Reactivation Drift.” Neuron. Cell
Press, 2025. https://doi.org/10.1016/j.neuron.2025.02.025.
ieee: L. Bollmann, P. Baracskay, F. Stella, and J. L. Csicsvari, “Sleep stages antagonistically
modulate reactivation drift,” Neuron, vol. 113, no. 9. Cell Press, p. 1446–1459.e6,
2025.
ista: Bollmann L, Baracskay P, Stella F, Csicsvari JL. 2025. Sleep stages antagonistically
modulate reactivation drift. Neuron. 113(9), 1446–1459.e6.
mla: Bollmann, Lars, et al. “Sleep Stages Antagonistically Modulate Reactivation
Drift.” Neuron, vol. 113, no. 9, Cell Press, 2025, p. 1446–1459.e6, doi:10.1016/j.neuron.2025.02.025.
short: L. Bollmann, P. Baracskay, F. Stella, J.L. Csicsvari, Neuron 113 (2025) 1446–1459.e6.
corr_author: '1'
date_created: 2025-04-06T22:01:32Z
date_published: 2025-05-07T00:00:00Z
date_updated: 2026-10-20T08:54:27Z
day: '07'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2025.02.025
ec_funded: 1
external_id:
isi:
- '001510440400001'
pmid:
- '40132588'
file:
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checksum: 5e57852a45a78a751dd3a5e807bf015f
content_type: application/pdf
creator: dernst
date_created: 2025-08-05T12:43:44Z
date_updated: 2025-08-05T12:43:44Z
file_id: '20133'
file_name: 2025_Neuron_Bollmann.pdf
file_size: 27047730
relation: main_file
success: 1
file_date_updated: 2025-08-05T12:43:44Z
fulldoi: https://doi.org/10.1016/j.neuron.2025.02.025
has_accepted_license: '1'
intvolume: ' 113'
isi: 1
issue: '9'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 1446-1459.e6
pmid: 1
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
- _id: 2654F984-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I 3713-B27
name: Interneuro plasticity during spatial learning
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
issn:
- 0896-6273
publication_status: published
publisher: Cell Press
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/how-sleep-keeps-our-memories-fresh/
scopus_import: '1'
status: public
title: Sleep stages antagonistically modulate reactivation drift
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 113
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
_id: '15381'
abstract:
- lang: eng
text: 'Cholecystokinin-expressing interneurons (CCKIs) are hypothesized to shape
pyramidal cell-firing patterns and regulate network oscillations and related network
state transitions. To directly probe their role in the CA1 region, we silenced
their activity using optogenetic and chemogenetic tools in mice. Opto-tagged CCKIs
revealed a heterogeneous population, and their optogenetic silencing triggered
wide disinhibitory network changes affecting both pyramidal cells and other interneurons.
CCKI silencing enhanced pyramidal cell burst firing and altered the temporal coding
of place cells: theta phase precession was disrupted, whereas sequence reactivation
was enhanced. Chemogenetic CCKI silencing did not alter the acquisition of spatial
reference memories on the Morris water maze but enhanced the recall of contextual
fear memories and enabled selective recall when similar environments were tested.
This work suggests the key involvement of CCKIs in the control of place-cell temporal
coding and the formation of contextual memories.'
acknowledged_ssus:
- _id: M-Shop
- _id: Bio
- _id: LifeSc
- _id: PreCl
acknowledgement: We thank the kind donations from Andrea Varro, Brian Sauer, Edward
Boyden, and Peter Jonas. We thank Jago Wallenschus, Kerstin Kronenbitter, and Didier
Gremelle for outstanding technical support; Laura Bollepalli for initial viral targeting
experiments; Cihan Önal for initial electrophysiology experiments; Yoav Ben-Simon
for histological advice; and Anton Nikitenko for contributing to the analysis. We
acknowledge support from the Miba Machine Shop, Bioimaging-, Life Science- and Pre-Clinical
Facilities at ISTA. This work was supported by the Austrian Science Fund (FWF I3713
to J.C. as part of the FOR 2143 research consortium), the Deutsche Forschungsgemeinschaft
(DFG) (WU 503/2-2 to P.W.), and the Medical Research Council, United Kingdom (grant
G1100546/2 to P.W.).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Dámaris K
full_name: Rangel Guerrero, Dámaris K
id: 4871BCE6-F248-11E8-B48F-1D18A9856A87
last_name: Rangel Guerrero
orcid: 0000-0002-8602-4374
- first_name: Kira
full_name: Balueva, Kira
last_name: Balueva
- first_name: Uladzislau
full_name: Barayeu, Uladzislau
id: b515be12-ec90-11ea-b966-d0b5e15613d2
last_name: Barayeu
- first_name: Peter
full_name: Baracskay, Peter
id: 361CC00E-F248-11E8-B48F-1D18A9856A87
last_name: Baracskay
- first_name: Igor
full_name: Gridchyn, Igor
id: 4B60654C-F248-11E8-B48F-1D18A9856A87
last_name: Gridchyn
orcid: 0000-0002-1807-1929
- first_name: Michele
full_name: Nardin, Michele
id: 30BD0376-F248-11E8-B48F-1D18A9856A87
last_name: Nardin
orcid: 0000-0001-8849-6570
- first_name: Chiara N
full_name: Roth, Chiara N
id: 37BB4FB6-F248-11E8-B48F-1D18A9856A87
last_name: Roth
- first_name: Peer
full_name: Wulff, Peer
last_name: Wulff
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Rangel Guerrero DK, Balueva K, Barayeu U, et al. Hippocampal cholecystokinin-expressing
interneurons regulate temporal coding and contextual learning. Neuron.
2024;112(12):2045-2061.e10. doi:10.1016/j.neuron.2024.03.019
apa: Rangel Guerrero, D. K., Balueva, K., Barayeu, U., Baracskay, P., Gridchyn,
I., Nardin, M., … Csicsvari, J. L. (2024). Hippocampal cholecystokinin-expressing
interneurons regulate temporal coding and contextual learning. Neuron.
Cell Press. https://doi.org/10.1016/j.neuron.2024.03.019
chicago: Rangel Guerrero, Dámaris K, Kira Balueva, Uladzislau Barayeu, Peter Baracskay,
Igor Gridchyn, Michele Nardin, Chiara N Roth, Peer Wulff, and Jozsef L Csicsvari.
“Hippocampal Cholecystokinin-Expressing Interneurons Regulate Temporal Coding
and Contextual Learning.” Neuron. Cell Press, 2024. https://doi.org/10.1016/j.neuron.2024.03.019.
ieee: D. K. Rangel Guerrero et al., “Hippocampal cholecystokinin-expressing
interneurons regulate temporal coding and contextual learning,” Neuron,
vol. 112, no. 12. Cell Press, p. 2045–2061.e10, 2024.
ista: Rangel Guerrero DK, Balueva K, Barayeu U, Baracskay P, Gridchyn I, Nardin
M, Roth CN, Wulff P, Csicsvari JL. 2024. Hippocampal cholecystokinin-expressing
interneurons regulate temporal coding and contextual learning. Neuron. 112(12),
2045–2061.e10.
mla: Rangel Guerrero, Dámaris K., et al. “Hippocampal Cholecystokinin-Expressing
Interneurons Regulate Temporal Coding and Contextual Learning.” Neuron,
vol. 112, no. 12, Cell Press, 2024, p. 2045–2061.e10, doi:10.1016/j.neuron.2024.03.019.
short: D.K. Rangel Guerrero, K. Balueva, U. Barayeu, P. Baracskay, I. Gridchyn,
M. Nardin, C.N. Roth, P. Wulff, J.L. Csicsvari, Neuron 112 (2024) 2045–2061.e10.
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: "Data reported in this paper can be shared by the lead
contact upon justified request.\r\n\r\nThis paper does not report original code.\r\n\r\nAny
additional information required to reanalyze the data reported in this work is available
from the corresponding authors upon request."
date_created: 2024-05-12T22:01:03Z
date_published: 2024-06-19T00:00:00Z
date_updated: 2026-10-15T08:38:29Z
day: '19'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2024.03.019
external_id:
isi:
- '001300571400001'
pmid:
- '38636524'
file:
- access_level: open_access
checksum: de5b18ff293d42bd90e83a193e889844
content_type: application/pdf
creator: dernst
date_created: 2025-01-09T09:15:31Z
date_updated: 2025-01-09T09:15:31Z
file_id: '18798'
file_name: 2024_Neuron_RangelGuerrero.pdf
file_size: 9149079
relation: main_file
success: 1
file_date_updated: 2025-01-09T09:15:31Z
fulldoi: https://doi.org/10.1016/j.neuron.2024.03.019
has_accepted_license: '1'
intvolume: ' 112'
isi: 1
issue: '12'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 2045-2061.e10
pmid: 1
project:
- _id: 2654F984-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I 3713-B27
name: Interneuro plasticity during spatial learning
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
issn:
- 0896-6273
publication_status: published
publisher: Cell Press
quality_controlled: '1'
researchdata_availability: upon request
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Hippocampal cholecystokinin-expressing interneurons regulate temporal coding
and contextual learning
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 112
year: '2024'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '14843'
abstract:
- lang: eng
text: The coupling between Ca2+ channels and release sensors is a key factor defining
the signaling properties of a synapse. However, the coupling nanotopography at
many synapses remains unknown, and it is unclear how it changes during development.
To address these questions, we examined coupling at the cerebellar inhibitory
basket cell (BC)-Purkinje cell (PC) synapse. Biophysical analysis of transmission
by paired recording and intracellular pipette perfusion revealed that the effects
of exogenous Ca2+ chelators decreased during development, despite constant reliance
of release on P/Q-type Ca2+ channels. Structural analysis by freeze-fracture replica
labeling (FRL) and transmission electron microscopy (EM) indicated that presynaptic
P/Q-type Ca2+ channels formed nanoclusters throughout development, whereas docked
vesicles were only clustered at later developmental stages. Modeling suggested
a developmental transformation from a more random to a more clustered coupling
nanotopography. Thus, presynaptic signaling developmentally approaches a point-to-point
configuration, optimizing speed, reliability, and energy efficiency of synaptic
transmission.
acknowledged_ssus:
- _id: EM-Fac
- _id: PreCl
- _id: M-Shop
acknowledgement: We thank Drs. David DiGregorio and Erwin Neher for critically reading
an earlier version of the manuscript, Ralf Schneggenburger for helpful discussions,
Benjamin Suter and Katharina Lichter for support with image analysis, Chris Wojtan
for advice on numerical solution of partial differential equations, Maria Reva for
help with Ripley analysis, Alois Schlögl for programming, and Akari Hagiwara and
Toshihisa Ohtsuka for anti-ELKS antibody. We are grateful to Florian Marr, Christina
Altmutter, and Vanessa Zheden for excellent technical assistance and to Eleftheria
Kralli-Beller for manuscript editing. This research was supported by the Scientific
Services Units (SSUs) of ISTA (Electron Microscopy Facility, Preclinical Facility,
and Machine Shop). The project received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation program (grant
agreement no. 692692), the Fonds zur Förderung der Wissenschaftlichen Forschung
(Z 312-B27, Wittgenstein award; P 36232-B), all to P.J., and a DOC fellowship of
the Austrian Academy of Sciences to J.-J.C.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: JingJing
full_name: Chen, JingJing
id: 2C4E65C8-F248-11E8-B48F-1D18A9856A87
last_name: Chen
- first_name: Walter
full_name: Kaufmann, Walter
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: Chong
full_name: Chen, Chong
id: 3DFD581A-F248-11E8-B48F-1D18A9856A87
last_name: Chen
- first_name: Itaru
full_name: Arai, Itaru
id: 32A73F6C-F248-11E8-B48F-1D18A9856A87
last_name: Arai
- first_name: Olena
full_name: Kim, Olena
id: 3F8ABDDA-F248-11E8-B48F-1D18A9856A87
last_name: Kim
orcid: 0000-0003-2344-1039
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Chen J, Kaufmann W, Chen C, et al. Developmental transformation of Ca2+ channel-vesicle
nanotopography at a central GABAergic synapse. Neuron. 2024;112(5):755-771.e9.
doi:10.1016/j.neuron.2023.12.002
apa: Chen, J., Kaufmann, W., Chen, C., Arai, itaru, Kim, O., Shigemoto, R., &
Jonas, P. M. (2024). Developmental transformation of Ca2+ channel-vesicle nanotopography
at a central GABAergic synapse. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2023.12.002
chicago: Chen, JingJing, Walter Kaufmann, Chong Chen, itaru Arai, Olena Kim, Ryuichi
Shigemoto, and Peter M Jonas. “Developmental Transformation of Ca2+ Channel-Vesicle
Nanotopography at a Central GABAergic Synapse.” Neuron. Elsevier, 2024.
https://doi.org/10.1016/j.neuron.2023.12.002.
ieee: J. Chen et al., “Developmental transformation of Ca2+ channel-vesicle
nanotopography at a central GABAergic synapse,” Neuron, vol. 112, no. 5.
Elsevier, p. 755–771.e9, 2024.
ista: Chen J, Kaufmann W, Chen C, Arai itaru, Kim O, Shigemoto R, Jonas PM. 2024.
Developmental transformation of Ca2+ channel-vesicle nanotopography at a central
GABAergic synapse. Neuron. 112(5), 755–771.e9.
mla: Chen, JingJing, et al. “Developmental Transformation of Ca2+ Channel-Vesicle
Nanotopography at a Central GABAergic Synapse.” Neuron, vol. 112, no. 5,
Elsevier, 2024, p. 755–771.e9, doi:10.1016/j.neuron.2023.12.002.
short: J. Chen, W. Kaufmann, C. Chen, itaru Arai, O. Kim, R. Shigemoto, P.M. Jonas,
Neuron 112 (2024) 755–771.e9.
corr_author: '1'
date_created: 2024-01-21T23:00:56Z
date_published: 2024-03-06T00:00:00Z
date_updated: 2026-11-13T23:31:07Z
day: '06'
ddc:
- '570'
department:
- _id: PeJo
- _id: EM-Fac
- _id: RySh
doi: 10.1016/j.neuron.2023.12.002
ec_funded: 1
external_id:
isi:
- '001202925700001'
pmid:
- '38215739'
file:
- access_level: open_access
checksum: 30098b4f0209556ddfb3540a23d07ca5
content_type: application/pdf
creator: dernst
date_created: 2025-04-23T14:02:08Z
date_updated: 2025-04-23T14:02:08Z
file_id: '19614'
file_name: 2024_Neuron_Chen.pdf
file_size: 8192355
relation: main_file
success: 1
file_date_updated: 2025-04-23T14:02:08Z
fulldoi: https://doi.org/10.1016/j.neuron.2023.12.002
has_accepted_license: '1'
intvolume: ' 112'
isi: 1
issue: '5'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 755-771.e9
pmid: 1
project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '692692'
name: Biophysics and circuit function of a giant cortical glutamatergic synapse
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00312
name: Synaptic communication in neuronal microcircuits
- _id: bd88be38-d553-11ed-ba76-81d5a70a6ef5
grant_number: P36232
name: Mechanisms of GABA release in hippocampal circuits
- _id: 26B66A3E-B435-11E9-9278-68D0E5697425
grant_number: '25383'
name: Development of nanodomain coupling between Ca2+ channels and release sensors
at a central inhibitory synapse
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
link:
- description: News on ISTA Website
relation: press_release
url: https://ista.ac.at/en/news/synapses-brought-to-the-point/
record:
- id: '15101'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Developmental transformation of Ca2+ channel-vesicle nanotopography at a central
GABAergic synapse
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 112
year: '2024'
...
---
OA_place: publisher
OA_type: free access
_id: '12542'
abstract:
- lang: eng
text: In this issue of Neuron, Espinosa-Medina et al.1 present the TEMPO (Temporal
Encoding and Manipulation in a Predefined Order) system, which enables the marking
and genetic manipulation of sequentially generated cell lineages in vertebrate
species in vivo.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Ana
full_name: Villalba Requena, Ana
id: 68cb85a0-39f7-11eb-9559-9aaab4f6a247
last_name: Villalba Requena
orcid: 0000-0002-5615-5277
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
citation:
ama: Villalba Requena A, Hippenmeyer S. Going back in time with TEMPO. Neuron.
2023;111(3):291-293. doi:10.1016/j.neuron.2023.01.006
apa: Villalba Requena, A., & Hippenmeyer, S. (2023). Going back in time with
TEMPO. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2023.01.006
chicago: Villalba Requena, Ana, and Simon Hippenmeyer. “Going Back in Time with
TEMPO.” Neuron. Elsevier, 2023. https://doi.org/10.1016/j.neuron.2023.01.006.
ieee: A. Villalba Requena and S. Hippenmeyer, “Going back in time with TEMPO,” Neuron,
vol. 111, no. 3. Elsevier, pp. 291–293, 2023.
ista: Villalba Requena A, Hippenmeyer S. 2023. Going back in time with TEMPO. Neuron.
111(3), 291–293.
mla: Villalba Requena, Ana, and Simon Hippenmeyer. “Going Back in Time with TEMPO.”
Neuron, vol. 111, no. 3, Elsevier, 2023, pp. 291–93, doi:10.1016/j.neuron.2023.01.006.
short: A. Villalba Requena, S. Hippenmeyer, Neuron 111 (2023) 291–293.
corr_author: '1'
date_created: 2023-02-12T23:00:58Z
date_published: 2023-02-01T00:00:00Z
date_updated: 2026-06-18T17:27:44Z
day: '01'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1016/j.neuron.2023.01.006
external_id:
isi:
- '000994473300001'
pmid:
- '36731425'
fulldoi: https://doi.org/10.1016/j.neuron.2023.01.006
intvolume: ' 111'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.neuron.2023.01.006
month: '02'
oa: 1
oa_version: Published Version
page: 291-293
pmid: 1
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Going back in time with TEMPO
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 111
year: '2023'
...
---
_id: '10753'
abstract:
- lang: eng
text: This is a comment on "Meta-learning synaptic plasticity and memory addressing
for continual familiarity detection." Neuron. 2022 Feb 2;110(3):544-557.e8.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Basile J
full_name: Confavreux, Basile J
id: C7610134-B532-11EA-BD9F-F5753DDC885E
last_name: Confavreux
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
citation:
ama: 'Confavreux BJ, Vogels TP. A familiar thought: Machines that replace us? Neuron.
2022;110(3):361-362. doi:10.1016/j.neuron.2022.01.014'
apa: 'Confavreux, B. J., & Vogels, T. P. (2022). A familiar thought: Machines
that replace us? Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2022.01.014'
chicago: 'Confavreux, Basile J, and Tim P Vogels. “A Familiar Thought: Machines
That Replace Us?” Neuron. Elsevier, 2022. https://doi.org/10.1016/j.neuron.2022.01.014.'
ieee: 'B. J. Confavreux and T. P. Vogels, “A familiar thought: Machines that replace
us?,” Neuron, vol. 110, no. 3. Elsevier, pp. 361–362, 2022.'
ista: 'Confavreux BJ, Vogels TP. 2022. A familiar thought: Machines that replace
us? Neuron. 110(3), 361–362.'
mla: 'Confavreux, Basile J., and Tim P. Vogels. “A Familiar Thought: Machines That
Replace Us?” Neuron, vol. 110, no. 3, Elsevier, 2022, pp. 361–62, doi:10.1016/j.neuron.2022.01.014.'
short: B.J. Confavreux, T.P. Vogels, Neuron 110 (2022) 361–362.
corr_author: '1'
date_created: 2022-02-13T23:01:34Z
date_published: 2022-02-02T00:00:00Z
date_updated: 2026-06-18T08:47:45Z
day: '02'
ddc:
- '570'
department:
- _id: TiVo
doi: 10.1016/j.neuron.2022.01.014
external_id:
isi:
- '000751819100005'
pmid:
- '35114107'
fulldoi: https://doi.org/10.1016/j.neuron.2022.01.014
intvolume: ' 110'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.neuron.2022.01.014
month: '02'
oa: 1
oa_version: Published Version
page: 361-362
pmid: 1
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'A familiar thought: Machines that replace us?'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 110
year: '2022'
...
---
_id: '8544'
abstract:
- lang: eng
text: The synaptotrophic hypothesis posits that synapse formation stabilizes dendritic
branches, yet this hypothesis has not been causally tested in vivo in the mammalian
brain. Presynaptic ligand cerebellin-1 (Cbln1) and postsynaptic receptor GluD2
mediate synaptogenesis between granule cells and Purkinje cells in the molecular
layer of the cerebellar cortex. Here we show that sparse but not global knockout
of GluD2 causes under-elaboration of Purkinje cell dendrites in the deep molecular
layer and overelaboration in the superficial molecular layer. Developmental, overexpression,
structure-function, and genetic epistasis analyses indicate that dendrite morphogenesis
defects result from competitive synaptogenesis in a Cbln1/GluD2-dependent manner.
A generative model of dendritic growth based on competitive synaptogenesis largely
recapitulates GluD2 sparse and global knockout phenotypes. Our results support
the synaptotrophic hypothesis at initial stages of dendrite development, suggest
a second mode in which cumulative synapse formation inhibits further dendrite
growth, and highlight the importance of competition in dendrite morphogenesis.
acknowledgement: We thank M. Mishina for GluD2fl frozen embryos, T.C. Südhof and J.I.
Morgan for Cbln1fl mice, L. Anderson for help in generating the MADM alleles, W.
Joo for a previously unpublished construct, M. Yuzaki, K. Shen, J. Ding, and members
of the Luo lab, including J.M. Kebschull, H. Li, J. Li, T. Li, C.M. McLaughlin,
D. Pederick, J. Ren, D.C. Wang and C. Xu for discussions and critiques of the manuscript,
and M. Yuzaki for supporting Y.H.T. during the final phase of this project. Y.H.T.
was supported by a JSPS fellowship; S.A.S. was supported by a Stanford Graduate
Fellowship and an NSF Predoctoral Fellowship; L.J. is supported by a Stanford Graduate
Fellowship and an NSF Predoctoral Fellowship; M.J.W. is supported by a Burroughs
Wellcome Fund CASI Award. This work was supported by an NIH grant (R01-NS050538)
to L.L.; the European Research Council (ERC) under the European Union's Horizon
2020 research and innovations programme (No. 725780 LinPro) to S.H.; and Simons
and James S. McDonnell Foundations and an NSF CAREER award to S.G.; L.L. is an HHMI
investigator.
article_processing_charge: No
article_type: original
author:
- first_name: Yukari H.
full_name: Takeo, Yukari H.
last_name: Takeo
- first_name: S. Andrew
full_name: Shuster, S. Andrew
last_name: Shuster
- first_name: Linnie
full_name: Jiang, Linnie
last_name: Jiang
- first_name: Miley
full_name: Hu, Miley
last_name: Hu
- first_name: David J.
full_name: Luginbuhl, David J.
last_name: Luginbuhl
- first_name: Thomas
full_name: Rülicke, Thomas
last_name: Rülicke
- first_name: Ximena
full_name: Contreras, Ximena
id: 475990FE-F248-11E8-B48F-1D18A9856A87
last_name: Contreras
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
- first_name: Mark J.
full_name: Wagner, Mark J.
last_name: Wagner
- first_name: Surya
full_name: Ganguli, Surya
last_name: Ganguli
- first_name: Liqun
full_name: Luo, Liqun
last_name: Luo
citation:
ama: Takeo YH, Shuster SA, Jiang L, et al. GluD2- and Cbln1-mediated competitive
synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells. Neuron.
2021;109(4):P629-644.E8. doi:10.1016/j.neuron.2020.11.028
apa: Takeo, Y. H., Shuster, S. A., Jiang, L., Hu, M., Luginbuhl, D. J., Rülicke,
T., … Luo, L. (2021). GluD2- and Cbln1-mediated competitive synaptogenesis shapes
the dendritic arbors of cerebellar Purkinje cells. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2020.11.028
chicago: Takeo, Yukari H., S. Andrew Shuster, Linnie Jiang, Miley Hu, David J. Luginbuhl,
Thomas Rülicke, Ximena Contreras, et al. “GluD2- and Cbln1-Mediated Competitive
Synaptogenesis Shapes the Dendritic Arbors of Cerebellar Purkinje Cells.” Neuron.
Elsevier, 2021. https://doi.org/10.1016/j.neuron.2020.11.028.
ieee: Y. H. Takeo et al., “GluD2- and Cbln1-mediated competitive synaptogenesis
shapes the dendritic arbors of cerebellar Purkinje cells,” Neuron, vol.
109, no. 4. Elsevier, p. P629–644.E8, 2021.
ista: Takeo YH, Shuster SA, Jiang L, Hu M, Luginbuhl DJ, Rülicke T, Contreras X,
Hippenmeyer S, Wagner MJ, Ganguli S, Luo L. 2021. GluD2- and Cbln1-mediated competitive
synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells. Neuron.
109(4), P629–644.E8.
mla: Takeo, Yukari H., et al. “GluD2- and Cbln1-Mediated Competitive Synaptogenesis
Shapes the Dendritic Arbors of Cerebellar Purkinje Cells.” Neuron, vol.
109, no. 4, Elsevier, 2021, p. P629–644.E8, doi:10.1016/j.neuron.2020.11.028.
short: Y.H. Takeo, S.A. Shuster, L. Jiang, M. Hu, D.J. Luginbuhl, T. Rülicke, X.
Contreras, S. Hippenmeyer, M.J. Wagner, S. Ganguli, L. Luo, Neuron 109 (2021)
P629–644.E8.
date_created: 2020-09-21T11:59:47Z
date_published: 2021-02-17T00:00:00Z
date_updated: 2025-09-10T09:58:28Z
day: '17'
department:
- _id: SiHi
doi: 10.1016/j.neuron.2020.11.028
ec_funded: 1
external_id:
isi:
- '000632657400006'
pmid:
- '33352118'
fulldoi: https://doi.org/10.1016/j.neuron.2020.11.028
intvolume: ' 109'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2020.06.14.151258
month: '02'
oa: 1
oa_version: Preprint
page: P629-644.E8
pmid: 1
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: GluD2- and Cbln1-mediated competitive synaptogenesis shapes the dendritic arbors
of cerebellar Purkinje cells
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 109
year: '2021'
...
---
OA_place: publisher
OA_type: free access
_id: '9793'
abstract:
- lang: eng
text: Astrocytes extensively infiltrate the neuropil to regulate critical aspects
of synaptic development and function. This process is regulated by transcellular
interactions between astrocytes and neurons via cell adhesion molecules. How astrocytes
coordinate developmental processes among one another to parse out the synaptic
neuropil and form non-overlapping territories is unknown. Here we identify a molecular
mechanism regulating astrocyte-astrocyte interactions during development to coordinate
astrocyte morphogenesis and gap junction coupling. We show that hepaCAM, a disease-linked,
astrocyte-enriched cell adhesion molecule, regulates astrocyte competition for
territory and morphological complexity in the developing mouse cortex. Furthermore,
conditional deletion of Hepacam from developing astrocytes significantly impairs
gap junction coupling between astrocytes and disrupts the balance between synaptic
excitation and inhibition. Mutations in HEPACAM cause megalencephalic leukoencephalopathy
with subcortical cysts in humans. Therefore, our findings suggest that disruption
of astrocyte self-organization mechanisms could be an underlying cause of neural
pathology.
acknowledgement: This work was supported by the National Institutes of Health (R01
DA047258 and R01 NS102237 to C.E., F32 NS100392 to K.T.B.) and the Holland-Trice
Brain Research Award (to C.E.). K.T.B. was supported by postdoctoral fellowships
from the Foerster-Bernstein Family and The Hartwell Foundation. The Hippenmeyer
lab was supported by the European Research Council (ERC) under the European Union’s
Horizon 2020 research and innovations program (725780 LinPro) to S.H. R.E. was supported
by Ministerio de Ciencia y Tecnología (RTI2018-093493-B-I00). We thank the Duke
Light Microscopy Core Facility, the Duke Transgenic Mouse Facility, Dr. U. Schulte
for assistance with proteomic experiments, and Dr. D. Silver for critical review
of the manuscript. Cartoon elements of figure panels were created using BioRender.com.
article_processing_charge: No
article_type: original
author:
- first_name: Katherine T.
full_name: Baldwin, Katherine T.
last_name: Baldwin
- first_name: Christabel X.
full_name: Tan, Christabel X.
last_name: Tan
- first_name: Samuel T.
full_name: Strader, Samuel T.
last_name: Strader
- first_name: Changyu
full_name: Jiang, Changyu
last_name: Jiang
- first_name: Justin T.
full_name: Savage, Justin T.
last_name: Savage
- first_name: Xabier
full_name: Elorza-Vidal, Xabier
last_name: Elorza-Vidal
- first_name: Ximena
full_name: Contreras, Ximena
id: 475990FE-F248-11E8-B48F-1D18A9856A87
last_name: Contreras
- first_name: Thomas
full_name: Rülicke, Thomas
last_name: Rülicke
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
- first_name: Raúl
full_name: Estévez, Raúl
last_name: Estévez
- first_name: Ru-Rong
full_name: Ji, Ru-Rong
last_name: Ji
- first_name: Cagla
full_name: Eroglu, Cagla
last_name: Eroglu
citation:
ama: Baldwin KT, Tan CX, Strader ST, et al. HepaCAM controls astrocyte self-organization
and coupling. Neuron. 2021;109(15):2427-2442.e10. doi:10.1016/j.neuron.2021.05.025
apa: Baldwin, K. T., Tan, C. X., Strader, S. T., Jiang, C., Savage, J. T., Elorza-Vidal,
X., … Eroglu, C. (2021). HepaCAM controls astrocyte self-organization and coupling.
Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2021.05.025
chicago: Baldwin, Katherine T., Christabel X. Tan, Samuel T. Strader, Changyu Jiang,
Justin T. Savage, Xabier Elorza-Vidal, Ximena Contreras, et al. “HepaCAM Controls
Astrocyte Self-Organization and Coupling.” Neuron. Elsevier, 2021. https://doi.org/10.1016/j.neuron.2021.05.025.
ieee: K. T. Baldwin et al., “HepaCAM controls astrocyte self-organization
and coupling,” Neuron, vol. 109, no. 15. Elsevier, p. 2427–2442.e10, 2021.
ista: Baldwin KT, Tan CX, Strader ST, Jiang C, Savage JT, Elorza-Vidal X, Contreras
X, Rülicke T, Hippenmeyer S, Estévez R, Ji R-R, Eroglu C. 2021. HepaCAM controls
astrocyte self-organization and coupling. Neuron. 109(15), 2427–2442.e10.
mla: Baldwin, Katherine T., et al. “HepaCAM Controls Astrocyte Self-Organization
and Coupling.” Neuron, vol. 109, no. 15, Elsevier, 2021, p. 2427–2442.e10,
doi:10.1016/j.neuron.2021.05.025.
short: K.T. Baldwin, C.X. Tan, S.T. Strader, C. Jiang, J.T. Savage, X. Elorza-Vidal,
X. Contreras, T. Rülicke, S. Hippenmeyer, R. Estévez, R.-R. Ji, C. Eroglu, Neuron
109 (2021) 2427–2442.e10.
date_created: 2021-08-06T09:08:25Z
date_published: 2021-08-04T00:00:00Z
date_updated: 2026-07-28T12:30:05Z
day: '04'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1016/j.neuron.2021.05.025
ec_funded: 1
external_id:
isi:
- '000692851900010'
pmid:
- '34171291'
fulldoi: https://doi.org/10.1016/j.neuron.2021.05.025
intvolume: ' 109'
isi: 1
issue: '15'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.neuron.2021.05.025
month: '08'
oa: 1
oa_version: Published Version
page: 2427-2442.e10
pmid: 1
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: HepaCAM controls astrocyte self-organization and coupling
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 109
year: '2021'
...
---
_id: '7684'
article_processing_charge: No
article_type: original
author:
- first_name: Igor
full_name: Gridchyn, Igor
id: 4B60654C-F248-11E8-B48F-1D18A9856A87
last_name: Gridchyn
orcid: 0000-0002-1807-1929
- first_name: Philipp
full_name: Schönenberger, Philipp
id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
last_name: Schönenberger
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. Assembly-specific disruption
of hippocampal replay leads to selective memory deficit. Neuron. 2020;106(2):291-300.e6.
doi:10.1016/j.neuron.2020.01.021
apa: Gridchyn, I., Schönenberger, P., O’Neill, J., & Csicsvari, J. L. (2020).
Assembly-specific disruption of hippocampal replay leads to selective memory deficit.
Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2020.01.021
chicago: Gridchyn, Igor, Philipp Schönenberger, Joseph O’Neill, and Jozsef L Csicsvari.
“Assembly-Specific Disruption of Hippocampal Replay Leads to Selective Memory
Deficit.” Neuron. Elsevier, 2020. https://doi.org/10.1016/j.neuron.2020.01.021.
ieee: I. Gridchyn, P. Schönenberger, J. O’Neill, and J. L. Csicsvari, “Assembly-specific
disruption of hippocampal replay leads to selective memory deficit,” Neuron,
vol. 106, no. 2. Elsevier, p. 291–300.e6, 2020.
ista: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. 2020. Assembly-specific
disruption of hippocampal replay leads to selective memory deficit. Neuron. 106(2),
291–300.e6.
mla: Gridchyn, Igor, et al. “Assembly-Specific Disruption of Hippocampal Replay
Leads to Selective Memory Deficit.” Neuron, vol. 106, no. 2, Elsevier,
2020, p. 291–300.e6, doi:10.1016/j.neuron.2020.01.021.
short: I. Gridchyn, P. Schönenberger, J. O’Neill, J.L. Csicsvari, Neuron 106 (2020)
291–300.e6.
date_created: 2020-04-26T22:00:45Z
date_published: 2020-04-22T00:00:00Z
date_updated: 2026-06-18T19:26:54Z
day: '22'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2020.01.021
ec_funded: 1
external_id:
isi:
- '000528268200013'
pmid:
- '32070475'
fulldoi: https://doi.org/10.1016/j.neuron.2020.01.021
intvolume: ' 106'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.neuron.2020.01.021
month: '04'
oa: 1
oa_version: Published Version
page: 291-300.e6
pmid: 1
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/librarian-of-memory/
scopus_import: '1'
status: public
title: Assembly-specific disruption of hippocampal replay leads to selective memory
deficit
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 106
year: '2020'
...
---
_id: '8674'
abstract:
- lang: eng
text: 'Extrasynaptic actions of glutamate are limited by high-affinity transporters
expressed by perisynaptic astroglial processes (PAPs): this helps maintain point-to-point
transmission in excitatory circuits. Memory formation in the brain is associated
with synaptic remodeling, but how this affects PAPs and therefore extrasynaptic
glutamate actions is poorly understood. Here, we used advanced imaging methods,
in situ and in vivo, to find that a classical synaptic memory mechanism, long-term
potentiation (LTP), triggers withdrawal of PAPs from potentiated synapses. Optical
glutamate sensors combined with patch-clamp and 3D molecular localization reveal
that LTP induction thus prompts spatial retreat of astroglial glutamate transporters,
boosting glutamate spillover and NMDA-receptor-mediated inter-synaptic cross-talk.
The LTP-triggered PAP withdrawal involves NKCC1 transporters and the actin-controlling
protein cofilin but does not depend on major Ca2+-dependent cascades in astrocytes.
We have therefore uncovered a mechanism by which a memory trace at one synapse
could alter signal handling by multiple neighboring connections.'
acknowledgement: We thank J. Angibaud for organotypic cultures and R. Chereau and
J. Tonnesen for help with the STED microscope; also D. Gonzales and the Neurocentre
Magendie INSERM U1215 Genotyping Platform, for breeding management and genotyping.
This work was supported by the Wellcome Trust Principal Fellowships 101896 and 212251,
ERC Advanced Grant 323113, ERC Proof-of-Concept Grant 767372, EC FP7 ITN 606950,
and EU CSA 811011 (D.A.R.); NRW-Rückkehrerpogramm, UCL Excellence Fellowship, German
Research Foundation (DFG) SPP1757 and SFB1089 (C.H.); Human Frontiers Science Program
(C.H., C.J.J., and H.J.); EMBO Long-Term Fellowship (L.B.); Marie Curie FP7 PIRG08-GA-2010-276995
(A.P.), ASTROMODULATION (S.R.); Equipe FRM DEQ 201 303 26519, Conseil Régional d’Aquitaine
R12056GG, INSERM (S.H.R.O.); ANR SUPERTri, ANR Castro (ANR-17-CE16-0002), R-13-BSV4-0007-01,
Université de Bordeaux, labex BRAIN (S.H.R.O. and U.V.N.); CNRS (A.P., S.H.R.O.,
and U.V.N.); HFSP, ANR CEXC, and France-BioImaging ANR-10-INSB-04 (U.V.N.); and
FP7 MemStick Project No. 201600 (M.G.S.).
article_processing_charge: No
article_type: original
author:
- first_name: Christian
full_name: Henneberger, Christian
last_name: Henneberger
- first_name: Lucie
full_name: Bard, Lucie
last_name: Bard
- first_name: Aude
full_name: Panatier, Aude
last_name: Panatier
- first_name: James P.
full_name: Reynolds, James P.
last_name: Reynolds
- first_name: Olga
full_name: Kopach, Olga
last_name: Kopach
- first_name: Nikolay I.
full_name: Medvedev, Nikolay I.
last_name: Medvedev
- first_name: Daniel
full_name: Minge, Daniel
last_name: Minge
- first_name: Michel K.
full_name: Herde, Michel K.
last_name: Herde
- first_name: Stefanie
full_name: Anders, Stefanie
last_name: Anders
- first_name: Igor
full_name: Kraev, Igor
last_name: Kraev
- first_name: Janosch P.
full_name: Heller, Janosch P.
last_name: Heller
- first_name: Sylvain
full_name: Rama, Sylvain
last_name: Rama
- first_name: Kaiyu
full_name: Zheng, Kaiyu
last_name: Zheng
- first_name: Thomas P.
full_name: Jensen, Thomas P.
last_name: Jensen
- first_name: Inmaculada
full_name: Sanchez-Romero, Inmaculada
id: 3D9C5D30-F248-11E8-B48F-1D18A9856A87
last_name: Sanchez-Romero
- first_name: Colin J.
full_name: Jackson, Colin J.
last_name: Jackson
- first_name: Harald L
full_name: Janovjak, Harald L
id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
last_name: Janovjak
orcid: 0000-0002-8023-9315
- first_name: Ole Petter
full_name: Ottersen, Ole Petter
last_name: Ottersen
- first_name: Erlend Arnulf
full_name: Nagelhus, Erlend Arnulf
last_name: Nagelhus
- first_name: Stephane H.R.
full_name: Oliet, Stephane H.R.
last_name: Oliet
- first_name: Michael G.
full_name: Stewart, Michael G.
last_name: Stewart
- first_name: U. VAlentin
full_name: Nägerl, U. VAlentin
last_name: Nägerl
- first_name: 'Dmitri A. '
full_name: 'Rusakov, Dmitri A. '
last_name: Rusakov
citation:
ama: Henneberger C, Bard L, Panatier A, et al. LTP induction boosts glutamate spillover
by driving withdrawal of perisynaptic astroglia. Neuron. 2020;108(5):P919-936.E11.
doi:10.1016/j.neuron.2020.08.030
apa: Henneberger, C., Bard, L., Panatier, A., Reynolds, J. P., Kopach, O., Medvedev,
N. I., … Rusakov, D. A. (2020). LTP induction boosts glutamate spillover by driving
withdrawal of perisynaptic astroglia. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2020.08.030
chicago: Henneberger, Christian, Lucie Bard, Aude Panatier, James P. Reynolds, Olga
Kopach, Nikolay I. Medvedev, Daniel Minge, et al. “LTP Induction Boosts Glutamate
Spillover by Driving Withdrawal of Perisynaptic Astroglia.” Neuron. Elsevier,
2020. https://doi.org/10.1016/j.neuron.2020.08.030.
ieee: C. Henneberger et al., “LTP induction boosts glutamate spillover by
driving withdrawal of perisynaptic astroglia,” Neuron, vol. 108, no. 5.
Elsevier, p. P919–936.E11, 2020.
ista: Henneberger C, Bard L, Panatier A, Reynolds JP, Kopach O, Medvedev NI, Minge
D, Herde MK, Anders S, Kraev I, Heller JP, Rama S, Zheng K, Jensen TP, Sanchez-Romero
I, Jackson CJ, Janovjak HL, Ottersen OP, Nagelhus EA, Oliet SHR, Stewart MG, Nägerl
UVa, Rusakov DA. 2020. LTP induction boosts glutamate spillover by driving withdrawal
of perisynaptic astroglia. Neuron. 108(5), P919–936.E11.
mla: Henneberger, Christian, et al. “LTP Induction Boosts Glutamate Spillover by
Driving Withdrawal of Perisynaptic Astroglia.” Neuron, vol. 108, no. 5,
Elsevier, 2020, p. P919–936.E11, doi:10.1016/j.neuron.2020.08.030.
short: C. Henneberger, L. Bard, A. Panatier, J.P. Reynolds, O. Kopach, N.I. Medvedev,
D. Minge, M.K. Herde, S. Anders, I. Kraev, J.P. Heller, S. Rama, K. Zheng, T.P.
Jensen, I. Sanchez-Romero, C.J. Jackson, H.L. Janovjak, O.P. Ottersen, E.A. Nagelhus,
S.H.R. Oliet, M.G. Stewart, U.Va. Nägerl, D.A. Rusakov, Neuron 108 (2020) P919–936.E11.
date_created: 2020-10-18T22:01:38Z
date_published: 2020-12-09T00:00:00Z
date_updated: 2026-04-16T09:33:03Z
day: '09'
ddc:
- '570'
department:
- _id: HaJa
doi: 10.1016/j.neuron.2020.08.030
external_id:
isi:
- '000603428000010'
pmid:
- '32976770'
file:
- access_level: open_access
checksum: 054562bb50165ef9a1f46631c1c5e36b
content_type: application/pdf
creator: dernst
date_created: 2020-12-10T14:42:09Z
date_updated: 2020-12-10T14:42:09Z
file_id: '8939'
file_name: 2020_Neuron_Henneberger.pdf
file_size: 7518960
relation: main_file
success: 1
file_date_updated: 2020-12-10T14:42:09Z
fulldoi: https://doi.org/10.1016/j.neuron.2020.08.030
has_accepted_license: '1'
intvolume: ' 108'
isi: 1
issue: '5'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: P919-936.E11
pmid: 1
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: LTP induction boosts glutamate spillover by driving withdrawal of perisynaptic
astroglia
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 108
year: '2020'
...
---
_id: '6454'
abstract:
- lang: eng
text: 'Adult neural stem cells and multiciliated ependymalcells are glial cells
essential for neurological func-tions. Together, they make up the adult neurogenicniche.
Using both high-throughput clonal analysisand single-cell resolution of progenitor
division pat-terns and fate, we show that these two componentsof the neurogenic
niche are lineally related: adult neu-ral stem cells are sister cells to ependymal
cells,whereas most ependymal cells arise from the termi-nal symmetric divisions
of the lineage. Unexpectedly,we found that the antagonist regulators of DNA repli-cation,
GemC1 and Geminin, can tune the proportionof neural stem cells and ependymal cells.
Our find-ings reveal the controlled dynamic of the neurogenicniche ontogeny and
identify the Geminin familymembers as key regulators of the initial pool of adultneural
stem cells.'
article_processing_charge: No
author:
- first_name: G
full_name: Ortiz-Álvarez, G
last_name: Ortiz-Álvarez
- first_name: M
full_name: Daclin, M
last_name: Daclin
- first_name: A
full_name: Shihavuddin, A
last_name: Shihavuddin
- first_name: P
full_name: Lansade, P
last_name: Lansade
- first_name: A
full_name: Fortoul, A
last_name: Fortoul
- first_name: M
full_name: Faucourt, M
last_name: Faucourt
- first_name: S
full_name: Clavreul, S
last_name: Clavreul
- first_name: ME
full_name: Lalioti, ME
last_name: Lalioti
- first_name: S
full_name: Taraviras, S
last_name: Taraviras
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
- first_name: J
full_name: Livet, J
last_name: Livet
- first_name: A
full_name: Meunier, A
last_name: Meunier
- first_name: A
full_name: Genovesio, A
last_name: Genovesio
- first_name: N
full_name: Spassky, N
last_name: Spassky
citation:
ama: Ortiz-Álvarez G, Daclin M, Shihavuddin A, et al. Adult neural stem cells and
multiciliated ependymal cells share a common lineage regulated by the Geminin
family members. Neuron. 2019;102(1):159-172.e7. doi:10.1016/j.neuron.2019.01.051
apa: Ortiz-Álvarez, G., Daclin, M., Shihavuddin, A., Lansade, P., Fortoul, A., Faucourt,
M., … Spassky, N. (2019). Adult neural stem cells and multiciliated ependymal
cells share a common lineage regulated by the Geminin family members. Neuron.
Elsevier. https://doi.org/10.1016/j.neuron.2019.01.051
chicago: Ortiz-Álvarez, G, M Daclin, A Shihavuddin, P Lansade, A Fortoul, M Faucourt,
S Clavreul, et al. “Adult Neural Stem Cells and Multiciliated Ependymal Cells
Share a Common Lineage Regulated by the Geminin Family Members.” Neuron.
Elsevier, 2019. https://doi.org/10.1016/j.neuron.2019.01.051.
ieee: G. Ortiz-Álvarez et al., “Adult neural stem cells and multiciliated
ependymal cells share a common lineage regulated by the Geminin family members,”
Neuron, vol. 102, no. 1. Elsevier, p. 159–172.e7, 2019.
ista: Ortiz-Álvarez G, Daclin M, Shihavuddin A, Lansade P, Fortoul A, Faucourt M,
Clavreul S, Lalioti M, Taraviras S, Hippenmeyer S, Livet J, Meunier A, Genovesio
A, Spassky N. 2019. Adult neural stem cells and multiciliated ependymal cells
share a common lineage regulated by the Geminin family members. Neuron. 102(1),
159–172.e7.
mla: Ortiz-Álvarez, G., et al. “Adult Neural Stem Cells and Multiciliated Ependymal
Cells Share a Common Lineage Regulated by the Geminin Family Members.” Neuron,
vol. 102, no. 1, Elsevier, 2019, p. 159–172.e7, doi:10.1016/j.neuron.2019.01.051.
short: G. Ortiz-Álvarez, M. Daclin, A. Shihavuddin, P. Lansade, A. Fortoul, M. Faucourt,
S. Clavreul, M. Lalioti, S. Taraviras, S. Hippenmeyer, J. Livet, A. Meunier, A.
Genovesio, N. Spassky, Neuron 102 (2019) 159–172.e7.
date_created: 2019-05-14T13:06:30Z
date_published: 2019-04-03T00:00:00Z
date_updated: 2025-04-14T07:43:05Z
day: '03'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1016/j.neuron.2019.01.051
ec_funded: 1
external_id:
isi:
- '000463337900018'
pmid:
- '30824354'
file:
- access_level: open_access
checksum: 1fb6e195c583eb0c5cabf26f69ff6675
content_type: application/pdf
creator: dernst
date_created: 2019-05-15T09:28:41Z
date_updated: 2020-07-14T12:47:30Z
file_id: '6457'
file_name: 2019_Neuron_Ortiz.pdf
file_size: 7288572
relation: main_file
file_date_updated: 2020-07-14T12:47:30Z
fulldoi: https://doi.org/10.1016/j.neuron.2019.01.051
has_accepted_license: '1'
intvolume: ' 102'
isi: 1
issue: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 159-172.e7
pmid: 1
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Adult neural stem cells and multiciliated ependymal cells share a common lineage
regulated by the Geminin family members
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 102
year: '2019'
...
---
_id: '6830'
article_processing_charge: No
article_type: letter_note
author:
- first_name: Ximena
full_name: Contreras, Ximena
id: 475990FE-F248-11E8-B48F-1D18A9856A87
last_name: Contreras
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
citation:
ama: Contreras X, Hippenmeyer S. Memo1 tiles the radial glial cell grid. Neuron.
2019;103(5):750-752. doi:10.1016/j.neuron.2019.08.021
apa: Contreras, X., & Hippenmeyer, S. (2019). Memo1 tiles the radial glial cell
grid. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2019.08.021
chicago: Contreras, Ximena, and Simon Hippenmeyer. “Memo1 Tiles the Radial Glial
Cell Grid.” Neuron. Elsevier, 2019. https://doi.org/10.1016/j.neuron.2019.08.021.
ieee: X. Contreras and S. Hippenmeyer, “Memo1 tiles the radial glial cell grid,”
Neuron, vol. 103, no. 5. Elsevier, pp. 750–752, 2019.
ista: Contreras X, Hippenmeyer S. 2019. Memo1 tiles the radial glial cell grid.
Neuron. 103(5), 750–752.
mla: Contreras, Ximena, and Simon Hippenmeyer. “Memo1 Tiles the Radial Glial Cell
Grid.” Neuron, vol. 103, no. 5, Elsevier, 2019, pp. 750–52, doi:10.1016/j.neuron.2019.08.021.
short: X. Contreras, S. Hippenmeyer, Neuron 103 (2019) 750–752.
date_created: 2019-08-25T22:00:50Z
date_published: 2019-09-04T00:00:00Z
date_updated: 2026-11-13T23:30:18Z
day: '04'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1016/j.neuron.2019.08.021
external_id:
isi:
- '000484400200002'
pmid:
- '31487522'
fulldoi: https://doi.org/10.1016/j.neuron.2019.08.021
intvolume: ' 103'
isi: 1
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.neuron.2019.08.021
month: '09'
oa: 1
oa_version: Published Version
page: 750-752
pmid: 1
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '7902'
relation: part_of_dissertation
status: public
scopus_import: '1'
status: public
title: Memo1 tiles the radial glial cell grid
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 103
year: '2019'
...
---
OA_place: publisher
OA_type: hybrid
_id: '1546'
abstract:
- lang: eng
text: Synaptic efficacy and precision are influenced by the coupling of voltage-gated
Ca2+ channels (VGCCs) to vesicles. But because the topography of VGCCs and their
proximity to vesicles is unknown, a quantitative understanding of the determinants
of vesicular release at nanometer scale is lacking. To investigate this, we combined
freeze-fracture replica immunogold labeling of Cav2.1 channels, local [Ca2+] imaging,
and patch pipette perfusion of EGTA at the calyx of Held. Between postnatal day
7 and 21, VGCCs formed variable sized clusters and vesicular release became less
sensitive to EGTA, whereas fixed Ca2+ buffer properties remained constant. Experimentally
constrained reaction-diffusion simulations suggest that Ca2+ sensors for vesicular
release are located at the perimeter of VGCC clusters (<30nm) and predict that
VGCC number per cluster determines vesicular release probability without altering
release time course. This "perimeter release model" provides a unifying
framework accounting for developmental changes in both synaptic efficacy and time
course.
acknowledgement: This work was supported by the Core Research for Evolutional Science
and Technology (CREST) of Japan Science and Technology Agency to T.T. and R.S.;
by the funding provided by Okinawa Institute of Science and Technology (OIST) to
T.T. and Y.N.; by JSPS Core-to-Core Program, A. Advanced Networks to T.T.; by the
Grant-in-Aid for Young Scientists from the Japanese Ministry of Education, Culture,
Sports, Science and Technology (#23700474) to Y.N.; by the Centre National de la
Recherche Scientifique through the Actions Thematiques et Initatives sur Programme,
Fondation Fyssen, Fondation pour la Recherche Medicale, Federation pour la Recherche
sur le Cerveau, Agence Nationale de la Recherche (ANR-2007-Neuro-008-01 and ANR-2010-BLAN-1411-01)
to D.D. and Y.N.; and by the European Commission Coordination Action ENINET (LSHM-CT-2005-19063)
to D.D. and R.A.S. R.A.S. and J.S.R. were funded by Wellcome Trust Senior (064413)
and Principal (095667) Research Fellowship and an ERC advance grant (294667) to
RAS.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Yukihiro
full_name: Nakamura, Yukihiro
last_name: Nakamura
- first_name: Harumi
full_name: Harada, Harumi
id: 2E55CDF2-F248-11E8-B48F-1D18A9856A87
last_name: Harada
orcid: 0000-0001-7429-7896
- first_name: Naomi
full_name: Kamasawa, Naomi
last_name: Kamasawa
- first_name: Ko
full_name: Matsui, Ko
last_name: Matsui
- first_name: Jason
full_name: Rothman, Jason
last_name: Rothman
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: R Angus
full_name: Silver, R Angus
last_name: Silver
- first_name: David
full_name: Digregorio, David
last_name: Digregorio
- first_name: Tomoyuki
full_name: Takahashi, Tomoyuki
last_name: Takahashi
citation:
ama: Nakamura Y, Harada H, Kamasawa N, et al. Nanoscale distribution of presynaptic
Ca2+ channels and its impact on vesicular release during development. Neuron.
2015;85(1):145-158. doi:10.1016/j.neuron.2014.11.019
apa: Nakamura, Y., Harada, H., Kamasawa, N., Matsui, K., Rothman, J., Shigemoto,
R., … Takahashi, T. (2015). Nanoscale distribution of presynaptic Ca2+ channels
and its impact on vesicular release during development. Neuron. Elsevier.
https://doi.org/10.1016/j.neuron.2014.11.019
chicago: Nakamura, Yukihiro, Harumi Harada, Naomi Kamasawa, Ko Matsui, Jason Rothman,
Ryuichi Shigemoto, R Angus Silver, David Digregorio, and Tomoyuki Takahashi. “Nanoscale
Distribution of Presynaptic Ca2+ Channels and Its Impact on Vesicular Release
during Development.” Neuron. Elsevier, 2015. https://doi.org/10.1016/j.neuron.2014.11.019.
ieee: Y. Nakamura et al., “Nanoscale distribution of presynaptic Ca2+ channels
and its impact on vesicular release during development,” Neuron, vol. 85,
no. 1. Elsevier, pp. 145–158, 2015.
ista: Nakamura Y, Harada H, Kamasawa N, Matsui K, Rothman J, Shigemoto R, Silver
RA, Digregorio D, Takahashi T. 2015. Nanoscale distribution of presynaptic Ca2+
channels and its impact on vesicular release during development. Neuron. 85(1),
145–158.
mla: Nakamura, Yukihiro, et al. “Nanoscale Distribution of Presynaptic Ca2+ Channels
and Its Impact on Vesicular Release during Development.” Neuron, vol. 85,
no. 1, Elsevier, 2015, pp. 145–58, doi:10.1016/j.neuron.2014.11.019.
short: Y. Nakamura, H. Harada, N. Kamasawa, K. Matsui, J. Rothman, R. Shigemoto,
R.A. Silver, D. Digregorio, T. Takahashi, Neuron 85 (2015) 145–158.
date_created: 2018-12-11T11:52:39Z
date_published: 2015-01-07T00:00:00Z
date_updated: 2025-09-23T09:38:39Z
day: '07'
ddc:
- '570'
department:
- _id: RySh
doi: 10.1016/j.neuron.2014.11.019
external_id:
isi:
- '000348295100015'
pmid:
- '25533484'
file:
- access_level: open_access
checksum: 725f4d5be2dbb44b283ce722645ef37d
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:47Z
date_updated: 2020-07-14T12:45:01Z
file_id: '5170'
file_name: IST-2016-482-v1+1_1-s2.0-S0896627314010472-main.pdf
file_size: 3080111
relation: main_file
file_date_updated: 2020-07-14T12:45:01Z
fulldoi: https://doi.org/10.1016/j.neuron.2014.11.019
has_accepted_license: '1'
intvolume: ' 85'
isi: 1
issue: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/3.0/
month: '01'
oa: 1
oa_version: Published Version
page: 145 - 158
pmid: 1
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '5625'
pubrep_id: '482'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nanoscale distribution of presynaptic Ca2+ channels and its impact on vesicular
release during development
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/3.0/legalcode
name: Creative Commons Attribution 3.0 Unported (CC BY 3.0)
short: CC BY (3.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 85
year: '2015'
...
---
OA_type: closed access
_id: '1791'
abstract:
- lang: eng
text: Acute gene inactivation using short hairpin RNA (shRNA, knockdown) in developing
brain is a powerful technique to study genetic function; however, discrepancies
between knockdown and knockout murine phenotypes have left unanswered questions.
For example, doublecortin (Dcx) knockdown but not knockout shows a neocortical
neuronal migration phenotype. Here we report that in utero electroporation of
shRNA, but not siRNA or miRNA, to Dcx demonstrates a migration phenotype in Dcx
knockouts akin to the effect in wild-type mice, suggestingshRNA-mediated off-target
toxicity. This effect wasnot limited to Dcx, as it was observed in Dclk1 knockouts,
as well as with a fraction of scrambled shRNAs, suggesting a sequence-dependent
but not sequence-specific effect. Profiling RNAs from electroporated cells showed
a defect in endogenous let7 miRNA levels, and disruption of let7 or Dicer recapitulated
the migration defect. The results suggest that shRNA-mediated knockdown can produce
untoward migration effects by altering endogenous miRNA pathways.
acknowledgement: This work was supported by the National Institutes of Health R01NS41537.
G.K. was supported by an EMBO Long Term Fellowship, S.L.B. by the A.P. Giannini
Fellowship, and A.G.F. by the Brain Behavior Research Foundation
article_processing_charge: No
article_type: original
author:
- first_name: Seungtae
full_name: Baek, Seungtae
last_name: Baek
- first_name: Géraldine
full_name: Kerjan, Géraldine
last_name: Kerjan
- first_name: Stephanie
full_name: Bielas, Stephanie
last_name: Bielas
- first_name: Jieun
full_name: Lee, Jieun
last_name: Lee
- first_name: Ali
full_name: Fenstermaker, Ali
last_name: Fenstermaker
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
- first_name: Joseph
full_name: Gleeson, Joseph
last_name: Gleeson
citation:
ama: Baek S, Kerjan G, Bielas S, et al. Off-target effect of doublecortin family
shRNA on neuronal migration associated with endogenous MicroRNA dysregulation.
Neuron. 2014;82(6):1255-1262. doi:10.1016/j.neuron.2014.04.036
apa: Baek, S., Kerjan, G., Bielas, S., Lee, J., Fenstermaker, A., Novarino, G.,
& Gleeson, J. (2014). Off-target effect of doublecortin family shRNA on neuronal
migration associated with endogenous MicroRNA dysregulation. Neuron. Elsevier.
https://doi.org/10.1016/j.neuron.2014.04.036
chicago: Baek, Seungtae, Géraldine Kerjan, Stephanie Bielas, Jieun Lee, Ali Fenstermaker,
Gaia Novarino, and Joseph Gleeson. “Off-Target Effect of Doublecortin Family ShRNA
on Neuronal Migration Associated with Endogenous MicroRNA Dysregulation.” Neuron.
Elsevier, 2014. https://doi.org/10.1016/j.neuron.2014.04.036.
ieee: S. Baek et al., “Off-target effect of doublecortin family shRNA on
neuronal migration associated with endogenous MicroRNA dysregulation,” Neuron,
vol. 82, no. 6. Elsevier, pp. 1255–1262, 2014.
ista: Baek S, Kerjan G, Bielas S, Lee J, Fenstermaker A, Novarino G, Gleeson J.
2014. Off-target effect of doublecortin family shRNA on neuronal migration associated
with endogenous MicroRNA dysregulation. Neuron. 82(6), 1255–1262.
mla: Baek, Seungtae, et al. “Off-Target Effect of Doublecortin Family ShRNA on Neuronal
Migration Associated with Endogenous MicroRNA Dysregulation.” Neuron, vol.
82, no. 6, Elsevier, 2014, pp. 1255–62, doi:10.1016/j.neuron.2014.04.036.
short: S. Baek, G. Kerjan, S. Bielas, J. Lee, A. Fenstermaker, G. Novarino, J. Gleeson,
Neuron 82 (2014) 1255–1262.
date_created: 2018-12-11T11:54:01Z
date_published: 2014-06-18T00:00:00Z
date_updated: 2026-09-04T11:50:27Z
day: '18'
doi: 10.1016/j.neuron.2014.04.036
extern: '1'
external_id:
pmid:
- '24945770'
fulldoi: https://doi.org/10.1016/j.neuron.2014.04.036
intvolume: ' 82'
issue: '6'
language:
- iso: eng
month: '06'
oa_version: None
page: 1255 - 1262
pmid: 1
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '5322'
status: public
title: Off-target effect of doublecortin family shRNA on neuronal migration associated
with endogenous MicroRNA dysregulation
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 82
year: '2014'
...
---
OA_type: free access
_id: '3823'
abstract:
- lang: eng
text: Two studies in this issue of Neuron (Kwon and Castillo and Rebola et al.)
show that the mossy fiber-CA3 pyramidal neuron synapse, a hippocampal synapse
well known for its presynaptic plasticity, exhibits a novel form of long-term
potentiation of NMDAR-mediated currents, which is induced and expressed postsynaptically.
article_processing_charge: No
article_type: original
author:
- first_name: Angharad
full_name: Kerr, Angharad
last_name: Kerr
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Kerr A, Jonas PM. The two sides of hippocampal mossy fiber plasticity (Review).
Neuron. 2008;57(1):5-7. doi:10.1016/j.neuron.2007.12.015
apa: Kerr, A., & Jonas, P. M. (2008). The two sides of hippocampal mossy fiber
plasticity (Review). Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2007.12.015
chicago: Kerr, Angharad, and Peter M Jonas. “The Two Sides of Hippocampal Mossy
Fiber Plasticity (Review).” Neuron. Elsevier, 2008. https://doi.org/10.1016/j.neuron.2007.12.015.
ieee: A. Kerr and P. M. Jonas, “The two sides of hippocampal mossy fiber plasticity
(Review),” Neuron, vol. 57, no. 1. Elsevier, pp. 5–7, 2008.
ista: Kerr A, Jonas PM. 2008. The two sides of hippocampal mossy fiber plasticity
(Review). Neuron. 57(1), 5–7.
mla: Kerr, Angharad, and Peter M. Jonas. “The Two Sides of Hippocampal Mossy Fiber
Plasticity (Review).” Neuron, vol. 57, no. 1, Elsevier, 2008, pp. 5–7,
doi:10.1016/j.neuron.2007.12.015.
short: A. Kerr, P.M. Jonas, Neuron 57 (2008) 5–7.
date_created: 2018-12-11T12:05:22Z
date_published: 2008-01-10T00:00:00Z
date_updated: 2026-05-29T11:07:13Z
day: '10'
doi: 10.1016/j.neuron.2007.12.015
extern: '1'
external_id:
pmid:
- '18184559'
fulldoi: https://doi.org/10.1016/j.neuron.2007.12.015
intvolume: ' 57'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 5 - 7
pmid: 1
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2388'
status: public
title: The two sides of hippocampal mossy fiber plasticity (Review)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 57
year: '2008'
...
---
OA_type: closed access
_id: '3824'
abstract:
- lang: eng
text: It is generally thought that transmitter release at mammalian central synapses
is triggered by Ca2+ microdomains, implying loose coupling between presynaptic
Ca2+ channels and Ca2+ sensors of exocytosis. Here we show that Ca2+ channel subunit
immunoreactivity is highly concentrated in the active zone of GABAergic presynaptic
terminals of putative parvalbumin-containing basket cells in the hippocampus.
Paired recording combined with presynaptic patch pipette perfusion revealed that
GABA release at basket cell-granule cell synapses is sensitive to millimolar concentrations
of the fast Ca2+ chelator BAPTA but insensitive to the slow Ca2+ chelator EGTA.
These results show that Ca2+ source and Ca2+ sensor are tightly coupled at this
synapse, with distances in the range of 10-20 nm. Models of Ca2+ inflow-exocytosis
coupling further reveal that the tightness of coupling increases efficacy, speed,
and temporal precision of transmitter release. Thus, tight coupling contributes
to fast feedforward and feedback inhibition in the hippocampal network.
article_processing_charge: No
article_type: original
author:
- first_name: Iancu
full_name: Bucurenciu, Iancu
last_name: Bucurenciu
- first_name: Ákos
full_name: Kulik, Ákos
last_name: Kulik
- first_name: Beat
full_name: Schwaller, Beat
last_name: Schwaller
- first_name: Michael
full_name: Frotscher, Michael
last_name: Frotscher
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Bucurenciu I, Kulik Á, Schwaller B, Frotscher M, Jonas PM. Nanodomain coupling
between Ca(2+) channels and Ca2+ sensors promotes fast and efficient transmitter
release at a cortical GABAergic synapse. Neuron. 2008;57(4):536-545. doi:10.1016/j.neuron.2007.12.026
apa: Bucurenciu, I., Kulik, Á., Schwaller, B., Frotscher, M., & Jonas, P. M.
(2008). Nanodomain coupling between Ca(2+) channels and Ca2+ sensors promotes
fast and efficient transmitter release at a cortical GABAergic synapse. Neuron.
Elsevier. https://doi.org/10.1016/j.neuron.2007.12.026
chicago: Bucurenciu, Iancu, Ákos Kulik, Beat Schwaller, Michael Frotscher, and Peter
M Jonas. “Nanodomain Coupling between Ca(2+) Channels and Ca2+ Sensors Promotes
Fast and Efficient Transmitter Release at a Cortical GABAergic Synapse.” Neuron.
Elsevier, 2008. https://doi.org/10.1016/j.neuron.2007.12.026.
ieee: I. Bucurenciu, Á. Kulik, B. Schwaller, M. Frotscher, and P. M. Jonas, “Nanodomain
coupling between Ca(2+) channels and Ca2+ sensors promotes fast and efficient
transmitter release at a cortical GABAergic synapse,” Neuron, vol. 57,
no. 4. Elsevier, pp. 536–45, 2008.
ista: Bucurenciu I, Kulik Á, Schwaller B, Frotscher M, Jonas PM. 2008. Nanodomain
coupling between Ca(2+) channels and Ca2+ sensors promotes fast and efficient
transmitter release at a cortical GABAergic synapse. Neuron. 57(4), 536–45.
mla: Bucurenciu, Iancu, et al. “Nanodomain Coupling between Ca(2+) Channels and
Ca2+ Sensors Promotes Fast and Efficient Transmitter Release at a Cortical GABAergic
Synapse.” Neuron, vol. 57, no. 4, Elsevier, 2008, pp. 536–45, doi:10.1016/j.neuron.2007.12.026.
short: I. Bucurenciu, Á. Kulik, B. Schwaller, M. Frotscher, P.M. Jonas, Neuron 57
(2008) 536–45.
date_created: 2018-12-11T12:05:22Z
date_published: 2008-02-28T00:00:00Z
date_updated: 2026-05-29T10:55:32Z
day: '28'
doi: 10.1016/j.neuron.2007.12.026
extern: '1'
external_id:
pmid:
- '18304483'
fulldoi: https://doi.org/10.1016/j.neuron.2007.12.026
intvolume: ' 57'
issue: '4'
language:
- iso: eng
month: '02'
oa_version: None
page: 536 - 45
pmid: 1
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2385'
status: public
title: Nanodomain coupling between Ca(2+) channels and Ca2+ sensors promotes fast
and efficient transmitter release at a cortical GABAergic synapse
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 57
year: '2008'
...
---
OA_type: closed access
_id: '3811'
abstract:
- lang: eng
text: Networks of GABAergic neurons are key elements in the generation of gamma
oscillations in the brain. Computational studies suggested that the emergence
of coherent oscillations requires hyperpolarizing inhibition. Here, we show that
GABA(A) receptor-mediated inhibition in mature interneurons of the hippocampal
dentate gyrus is shunting rather than hyperpolarizing. Unexpectedly, when shunting
inhibition is incorporated into a structured interneuron network model with fast
and strong synapses, coherent oscillations emerge. In comparison to hyperpolarizing
inhibition, networks with shunting inhibition show several advantages. First,
oscillations are generated with smaller tonic excitatory drive. Second, network
frequencies are tuned to the gamma band. Finally, robustness against heterogeneity
in the excitatory drive is markedly improved. In single interneurons, shunting
inhibition shortens the interspike interval for low levels of drive but prolongs
it for high levels, leading to homogenization of neuronal firing rates. Thus,
shunting inhibition may confer increased robustness to gamma oscillations in the
brain.
article_processing_charge: No
article_type: original
author:
- first_name: Imre
full_name: Vida, Imre
last_name: Vida
- first_name: Marlene
full_name: Bartos, Marlene
last_name: Bartos
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Vida I, Bartos M, Jonas PM. Shunting inhibition improves robustness of gamma
oscillations in hippocampal interneuron networks by homogenizing firing rates.
Neuron. 2006;49(1):107-117. doi:10.1016/j.neuron.2005.11.036
apa: Vida, I., Bartos, M., & Jonas, P. M. (2006). Shunting inhibition improves
robustness of gamma oscillations in hippocampal interneuron networks by homogenizing
firing rates. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2005.11.036
chicago: Vida, Imre, Marlene Bartos, and Peter M Jonas. “Shunting Inhibition Improves
Robustness of Gamma Oscillations in Hippocampal Interneuron Networks by Homogenizing
Firing Rates.” Neuron. Elsevier, 2006. https://doi.org/10.1016/j.neuron.2005.11.036.
ieee: I. Vida, M. Bartos, and P. M. Jonas, “Shunting inhibition improves robustness
of gamma oscillations in hippocampal interneuron networks by homogenizing firing
rates,” Neuron, vol. 49, no. 1. Elsevier, pp. 107–17, 2006.
ista: Vida I, Bartos M, Jonas PM. 2006. Shunting inhibition improves robustness
of gamma oscillations in hippocampal interneuron networks by homogenizing firing
rates. Neuron. 49(1), 107–17.
mla: Vida, Imre, et al. “Shunting Inhibition Improves Robustness of Gamma Oscillations
in Hippocampal Interneuron Networks by Homogenizing Firing Rates.” Neuron,
vol. 49, no. 1, Elsevier, 2006, pp. 107–17, doi:10.1016/j.neuron.2005.11.036.
short: I. Vida, M. Bartos, P.M. Jonas, Neuron 49 (2006) 107–17.
date_created: 2018-12-11T12:05:18Z
date_published: 2006-01-01T00:00:00Z
date_updated: 2026-08-27T09:32:57Z
day: '01'
doi: 10.1016/j.neuron.2005.11.036
extern: '1'
external_id:
pmid:
- '16387643'
fulldoi: https://doi.org/10.1016/j.neuron.2005.11.036
intvolume: ' 49'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 107 - 17
pmid: 1
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2398'
status: public
title: Shunting inhibition improves robustness of gamma oscillations in hippocampal
interneuron networks by homogenizing firing rates
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 49
year: '2006'
...
---
OA_type: closed access
_id: '3522'
abstract:
- lang: eng
text: We observed sharp wave/ripples (SWR) during exploration within brief (<
2.4 s) interruptions of or during theta oscillations. CA1 network responses of
SWRs occurring during exploration (eSWR) and SWRs detected in waking immobility
or sleep were similar. However, neuronal activity during eSWR was location dependent,
and eSWR-related firing was stronger inside the place field than outside. The
eSPW-related firing increase was stronger than the baseline increase inside compared
to outside, suggesting a “supralinear” summation of eSWR and place-selective inputs.
Pairs of cells with similar place fields and/or correlated firing during exploration
showed stronger coactivation during eSWRs and subsequent sleep-SWRs. Sequential
activation of place cells was not required for the reactivation of waking co-firing
patterns; cell pairs with symmetrical cross-correlations still showed reactivated
waking co-firing patterns during sleep-SWRs. We suggest that place-selective firing
during eSWRs facilitates initial associations between cells with similar place
fields that enable place-related ensemble patterns to recur during subsequent
sleep-SWRs.
article_processing_charge: No
article_type: original
author:
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Timothy
full_name: Senior, Timothy
last_name: Senior
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: O’Neill J, Senior T, Csicsvari JL. Place-selective firing of CA1 pyramidal
cells during sharp wave/ripple network patterns in exploratory behavior. Neuron.
2006;49(1):143-155. doi:10.1016/j.neuron.2005.10.037
apa: O’Neill, J., Senior, T., & Csicsvari, J. L. (2006). Place-selective firing
of CA1 pyramidal cells during sharp wave/ripple network patterns in exploratory
behavior. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2005.10.037
chicago: O’Neill, Joseph, Timothy Senior, and Jozsef L Csicsvari. “Place-Selective
Firing of CA1 Pyramidal Cells during Sharp Wave/Ripple Network Patterns in Exploratory
Behavior.” Neuron. Elsevier, 2006. https://doi.org/10.1016/j.neuron.2005.10.037.
ieee: J. O’Neill, T. Senior, and J. L. Csicsvari, “Place-selective firing of CA1
pyramidal cells during sharp wave/ripple network patterns in exploratory behavior,”
Neuron, vol. 49, no. 1. Elsevier, pp. 143–155, 2006.
ista: O’Neill J, Senior T, Csicsvari JL. 2006. Place-selective firing of CA1 pyramidal
cells during sharp wave/ripple network patterns in exploratory behavior. Neuron.
49(1), 143–155.
mla: O’Neill, Joseph, et al. “Place-Selective Firing of CA1 Pyramidal Cells during
Sharp Wave/Ripple Network Patterns in Exploratory Behavior.” Neuron, vol.
49, no. 1, Elsevier, 2006, pp. 143–55, doi:10.1016/j.neuron.2005.10.037.
short: J. O’Neill, T. Senior, J.L. Csicsvari, Neuron 49 (2006) 143–155.
date_created: 2018-12-11T12:03:46Z
date_published: 2006-01-05T00:00:00Z
date_updated: 2026-08-28T11:15:34Z
day: '05'
doi: 10.1016/j.neuron.2005.10.037
extern: '1'
external_id:
pmid:
- '16387646'
fulldoi: https://doi.org/10.1016/j.neuron.2005.10.037
intvolume: ' 49'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 143 - 155
pmid: 1
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2863'
status: public
title: Place-selective firing of CA1 pyramidal cells during sharp wave/ripple network
patterns in exploratory behavior
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 49
year: '2006'
...
---
OA_type: free access
_id: '3808'
abstract:
- lang: eng
text: Action potentials in central neurons are initiated near the axon initial segment,
propagate into the axon, and finally invade the presynaptic terminals, where they
trigger transmitter release. Voltage-gated Na(+) channels are key determinants
of excitability, but Na(+) channel density and properties in axons and presynaptic
terminals of cortical neurons have not been examined yet. In hippocampal mossy
fiber boutons, which emerge from parent axons en passant, Na(+) channels are very
abundant, with an estimated number of approximately 2000 channels per bouton.
Presynaptic Na(+) channels show faster inactivation kinetics than somatic channels,
suggesting differences between subcellular compartments of the same cell. Computational
analysis of action potential propagation in axon-multibouton structures reveals
that Na(+) channels in boutons preferentially amplify the presynaptic action potential
and enhance Ca(2+) inflow, whereas Na(+) channels in axons control the reliability
and speed of propagation. Thus, presynaptic and axonal Na(+) channels contribute
differentially to mossy fiber synaptic transmission.
article_processing_charge: No
article_type: original
author:
- first_name: Dominique
full_name: Engel, Dominique
last_name: Engel
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Engel D, Jonas PM. Presynaptic action potential amplification by voltage-gated
Na+ channels in hippocampal mossy fiber boutons. Neuron. 2005;45(3):405-417.
doi:10.1016/j.neuron.2004.12.048
apa: Engel, D., & Jonas, P. M. (2005). Presynaptic action potential amplification
by voltage-gated Na+ channels in hippocampal mossy fiber boutons. Neuron.
Elsevier. https://doi.org/10.1016/j.neuron.2004.12.048
chicago: Engel, Dominique, and Peter M Jonas. “Presynaptic Action Potential Amplification
by Voltage-Gated Na+ Channels in Hippocampal Mossy Fiber Boutons.” Neuron.
Elsevier, 2005. https://doi.org/10.1016/j.neuron.2004.12.048
.
ieee: D. Engel and P. M. Jonas, “Presynaptic action potential amplification by voltage-gated
Na+ channels in hippocampal mossy fiber boutons,” Neuron, vol. 45, no.
3. Elsevier, pp. 405–17, 2005.
ista: Engel D, Jonas PM. 2005. Presynaptic action potential amplification by voltage-gated
Na+ channels in hippocampal mossy fiber boutons. Neuron. 45(3), 405–17.
mla: Engel, Dominique, and Peter M. Jonas. “Presynaptic Action Potential Amplification
by Voltage-Gated Na+ Channels in Hippocampal Mossy Fiber Boutons.” Neuron,
vol. 45, no. 3, Elsevier, 2005, pp. 405–17, doi:10.1016/j.neuron.2004.12.048 .
short: D. Engel, P.M. Jonas, Neuron 45 (2005) 405–17.
date_created: 2018-12-11T12:05:17Z
date_published: 2005-01-01T00:00:00Z
date_updated: 2026-11-11T11:20:54Z
day: '01'
doi: '10.1016/j.neuron.2004.12.048 '
extern: '1'
external_id:
pmid:
- '15694327'
fulldoi: 'https://doi.org/10.1016/j.neuron.2004.12.048 '
intvolume: ' 45'
issue: '3'
language:
- iso: eng
month: '01'
oa_version: None
page: 405 - 17
pmid: 1
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2400'
status: public
title: Presynaptic action potential amplification by voltage-gated Na+ channels in
hippocampal mossy fiber boutons
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 45
year: '2005'
...
---
OA_place: publisher
OA_type: free access
_id: '3528'
abstract:
- lang: eng
text: Gamma frequency oscillations (30-100 Hz) have been suggested to underlie various
cognitive and motor functions. Here, we examine the generation of gamma oscillation
currents in the hippocampus, using two-dimensional, 96-site silicon probes. Two
gamma generators were identified, one in the dentate gyrus and another in the
CA3-CA1 regions. The coupling strength between the two oscillators varied during
both theta and nontheta states. Both pyramidal cells and interneurons were phase-locked
to gamma waves. Anatomical connectivity, rather than physical distance, determined
the coupling strength of the oscillating neurons. CA3 pyramidal neurons discharged
CA3 and CA1 interneurons at latencies indicative of monosynaptic connections.
Intrahippocampal gamma oscillation emerges in the CA3 recurrent system, which
entrains the CA1 region via its interneurons.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Brian
full_name: Jamieson, Brian
last_name: Jamieson
- first_name: Kensall
full_name: Wise, Kensall
last_name: Wise
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Jamieson B, Wise K, Buzsáki G. Mechanisms of gamma oscillations
in the hippocampus of the behaving rat. Neuron. 2003;37(2):311-322. doi:10.1016/S0896-6273(02)01169-8
apa: Csicsvari, J. L., Jamieson, B., Wise, K., & Buzsáki, G. (2003). Mechanisms
of gamma oscillations in the hippocampus of the behaving rat. Neuron. Elsevier.
https://doi.org/10.1016/S0896-6273(02)01169-8
chicago: Csicsvari, Jozsef L, Brian Jamieson, Kensall Wise, and György Buzsáki.
“Mechanisms of Gamma Oscillations in the Hippocampus of the Behaving Rat.” Neuron.
Elsevier, 2003. https://doi.org/10.1016/S0896-6273(02)01169-8.
ieee: J. L. Csicsvari, B. Jamieson, K. Wise, and G. Buzsáki, “Mechanisms of gamma
oscillations in the hippocampus of the behaving rat,” Neuron, vol. 37,
no. 2. Elsevier, pp. 311–322, 2003.
ista: Csicsvari JL, Jamieson B, Wise K, Buzsáki G. 2003. Mechanisms of gamma oscillations
in the hippocampus of the behaving rat. Neuron. 37(2), 311–322.
mla: Csicsvari, Jozsef L., et al. “Mechanisms of Gamma Oscillations in the Hippocampus
of the Behaving Rat.” Neuron, vol. 37, no. 2, Elsevier, 2003, pp. 311–22,
doi:10.1016/S0896-6273(02)01169-8.
short: J.L. Csicsvari, B. Jamieson, K. Wise, G. Buzsáki, Neuron 37 (2003) 311–322.
date_created: 2018-12-11T12:03:48Z
date_published: 2003-01-01T00:00:00Z
date_updated: 2026-05-21T07:50:07Z
day: '01'
doi: 10.1016/S0896-6273(02)01169-8
extern: '1'
external_id:
unknown:
- '12546825'
fulldoi: https://doi.org/10.1016/S0896-6273(02)01169-8
intvolume: ' 37'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/S0896-6273(02)01169-8
month: '01'
oa: 1
oa_version: Published Version
page: 311 - 322
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2857'
quality_controlled: '1'
status: public
title: Mechanisms of gamma oscillations in the hippocampus of the behaving rat
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 37
year: '2003'
...