---
OA_type: closed access
_id: '3935'
abstract:
- lang: eng
  text: Integrins regulate cell behavior through the assembly of multiprotein complexes
    at the site of cell adhesion. Parvins are components of such a multiprotein complex.
    They consist of three members (alpha-, beta-, and gamma-parvin), form a functional
    complex with integrin-linked kinase (ILK) and PINCH, and link integrins to the
    actin cytoskeleton. Whereas alpha- and beta-parvins are widely expressed, gamma-parvin
    has been reported to be expressed in hematopoietic organs. In the present study,
    we report the expression pattern of the parvins in hematopoietic cells and the
    phenotypic analysis of gamma-parvin-deficient mice. Whereas alpha-parvin is not
    expressed in hematopoietic cells, beta-parvin is only found in myeloid cells and
    gamma-parvin is present in both cells of the myeloid and lymphoid lineages, where
    it binds ILK. Surprisingly, loss of gamma-parvin expression had no effect on blood
    cell differentiation, proliferation, and survival and no consequence for the T-cell-dependent
    antibody response and lymphocyte and dendritic cell migration. These data indicate
    that despite the high expression of gamma-parvin in hematopoietic cells it must
    play a more subtle role for blood cell homeostasis.
article_processing_charge: No
article_type: original
author:
- first_name: Haiyan
  full_name: Chu, Haiyan
  last_name: Chu
- first_name: Ingo
  full_name: Thievessen, Ingo
  last_name: Thievessen
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
- first_name: Tim
  full_name: Lämmermann, Tim
  last_name: Lämmermann
- first_name: Ari
  full_name: Waisman, Ari
  last_name: Waisman
- first_name: Attila
  full_name: Braun, Attila
  last_name: Braun
- first_name: Angelika
  full_name: Noegel, Angelika
  last_name: Noegel
- first_name: Reinhard
  full_name: Fässler, Reinhard
  last_name: Fässler
citation:
  ama: Chu H, Thievessen I, Sixt MK, et al. γ-Parvin is dispensable for hematopoiesis,
    leukocyte trafficking, and T-cell-dependent antibody response. <i>Molecular and
    Cellular Biology</i>. 2006;26(5):1817-1825. doi:<a href="https://doi.org/10.1128/MCB.26.5.1817-1825.2006">10.1128/MCB.26.5.1817-1825.2006</a>
  apa: Chu, H., Thievessen, I., Sixt, M. K., Lämmermann, T., Waisman, A., Braun, A.,
    … Fässler, R. (2006). γ-Parvin is dispensable for hematopoiesis, leukocyte trafficking,
    and T-cell-dependent antibody response. <i>Molecular and Cellular Biology</i>.
    American Society for Microbiology. <a href="https://doi.org/10.1128/MCB.26.5.1817-1825.2006">https://doi.org/10.1128/MCB.26.5.1817-1825.2006</a>
  chicago: Chu, Haiyan, Ingo Thievessen, Michael K Sixt, Tim Lämmermann, Ari Waisman,
    Attila Braun, Angelika Noegel, and Reinhard Fässler. “γ-Parvin Is Dispensable
    for Hematopoiesis, Leukocyte Trafficking, and T-Cell-Dependent Antibody Response.”
    <i>Molecular and Cellular Biology</i>. American Society for Microbiology, 2006.
    <a href="https://doi.org/10.1128/MCB.26.5.1817-1825.2006">https://doi.org/10.1128/MCB.26.5.1817-1825.2006</a>.
  ieee: H. Chu <i>et al.</i>, “γ-Parvin is dispensable for hematopoiesis, leukocyte
    trafficking, and T-cell-dependent antibody response,” <i>Molecular and Cellular
    Biology</i>, vol. 26, no. 5. American Society for Microbiology, pp. 1817–1825,
    2006.
  ista: Chu H, Thievessen I, Sixt MK, Lämmermann T, Waisman A, Braun A, Noegel A,
    Fässler R. 2006. γ-Parvin is dispensable for hematopoiesis, leukocyte trafficking,
    and T-cell-dependent antibody response. Molecular and Cellular Biology. 26(5),
    1817–1825.
  mla: Chu, Haiyan, et al. “γ-Parvin Is Dispensable for Hematopoiesis, Leukocyte Trafficking,
    and T-Cell-Dependent Antibody Response.” <i>Molecular and Cellular Biology</i>,
    vol. 26, no. 5, American Society for Microbiology, 2006, pp. 1817–25, doi:<a href="https://doi.org/10.1128/MCB.26.5.1817-1825.2006">10.1128/MCB.26.5.1817-1825.2006</a>.
  short: H. Chu, I. Thievessen, M.K. Sixt, T. Lämmermann, A. Waisman, A. Braun, A.
    Noegel, R. Fässler, Molecular and Cellular Biology 26 (2006) 1817–1825.
date_created: 2018-12-11T12:05:58Z
date_published: 2006-03-01T00:00:00Z
date_updated: 2026-08-26T12:58:22Z
day: '01'
doi: 10.1128/MCB.26.5.1817-1825.2006
extern: '1'
external_id:
  pmid:
  - '16479001'
fulldoi: https://doi.org/10.1128/MCB.26.5.1817-1825.2006
intvolume: '        26'
issue: '5'
language:
- iso: eng
month: '03'
oa_version: None
page: 1817 - 1825
pmid: 1
publication: Molecular and Cellular Biology
publication_identifier:
  eissn:
  - 1098-5549
  issn:
  - 0270-7306
publication_status: published
publisher: American Society for Microbiology
publist_id: '2193'
status: public
title: γ-Parvin is dispensable for hematopoiesis, leukocyte trafficking, and T-cell-dependent
  antibody response
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 26
year: '2006'
...