---
_id: '11117'
abstract:
- lang: eng
  text: Over the last years it has become evident that the nuclear envelope (NE) is
    more than a passive membrane barrier that separates the nucleus from the cytoplasm.
    The NE not only controls the trafficking of macromolecules between the nucleoplasm
    and the cytosol, but also provides anchoring sites for chromosomes and cytoskeleton
    to the nuclear periphery. Targeting of chromatin to the NE might actually be part
    of gene expression regulation in eukaryotes. Mutations in certain NE proteins
    are associated with a diversity of human diseases, including muscular dystrophy,
    neuropathy, lipodistrophy, torsion dystonia and the premature aging condition
    progeria. Despite the importance of the NE for cell division and differentiation,
    relatively little is known about its biogenesis and its role in human diseases.
    It is our goal to provide a comprehensive view of the NE and to discuss possible
    implications of NE-associated changes for gene expression, chromatin organization
    and signal transduction.
article_processing_charge: No
article_type: review
author:
- first_name: M. A.
  full_name: D’Angelo, M. A.
  last_name: D’Angelo
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: D’Angelo MA, Hetzer M. The role of the nuclear envelope in cellular organization.
    <i>Cellular and Molecular Life Sciences</i>. 2006;63(3):316-332. doi:<a href="https://doi.org/10.1007/s00018-005-5361-3">10.1007/s00018-005-5361-3</a>
  apa: D’Angelo, M. A., &#38; Hetzer, M. (2006). The role of the nuclear envelope
    in cellular organization. <i>Cellular and Molecular Life Sciences</i>. Springer
    Nature. <a href="https://doi.org/10.1007/s00018-005-5361-3">https://doi.org/10.1007/s00018-005-5361-3</a>
  chicago: D’Angelo, M. A., and Martin Hetzer. “The Role of the Nuclear Envelope in
    Cellular Organization.” <i>Cellular and Molecular Life Sciences</i>. Springer
    Nature, 2006. <a href="https://doi.org/10.1007/s00018-005-5361-3">https://doi.org/10.1007/s00018-005-5361-3</a>.
  ieee: M. A. D’Angelo and M. Hetzer, “The role of the nuclear envelope in cellular
    organization,” <i>Cellular and Molecular Life Sciences</i>, vol. 63, no. 3. Springer
    Nature, pp. 316–332, 2006.
  ista: D’Angelo MA, Hetzer M. 2006. The role of the nuclear envelope in cellular
    organization. Cellular and Molecular Life Sciences. 63(3), 316–332.
  mla: D’Angelo, M. A., and Martin Hetzer. “The Role of the Nuclear Envelope in Cellular
    Organization.” <i>Cellular and Molecular Life Sciences</i>, vol. 63, no. 3, Springer
    Nature, 2006, pp. 316–32, doi:<a href="https://doi.org/10.1007/s00018-005-5361-3">10.1007/s00018-005-5361-3</a>.
  short: M.A. D’Angelo, M. Hetzer, Cellular and Molecular Life Sciences 63 (2006)
    316–332.
date_created: 2022-04-07T07:56:22Z
date_published: 2006-01-02T00:00:00Z
date_updated: 2024-10-14T11:30:38Z
day: '02'
doi: 10.1007/s00018-005-5361-3
extern: '1'
external_id:
  pmid:
  - '16389459'
intvolume: '        63'
issue: '3'
keyword:
- Cell Biology
- Cellular and Molecular Neuroscience
- Pharmacology
- Molecular Biology
- Molecular Medicine
language:
- iso: eng
month: '01'
oa_version: None
page: 316-332
pmid: 1
publication: Cellular and Molecular Life Sciences
publication_identifier:
  eissn:
  - 1420-9071
  issn:
  - 1420-682X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: The role of the nuclear envelope in cellular organization
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 63
year: '2006'
...