[{"title":"Photocatalytic cleavage of trityl protected thiols and alcohols","abstract":[{"lang":"eng","text":"We report the visible light photocatalytic cleavage of trityl thioethers or ethers under pH-neutral conditions. The method results in the formation of the respective symmetrical disulfides and alcohols in moderate to excellent yield. The protocol only requires the addition of a suitable photocatalyst and light rendering it orthogonal to several functionalities, including acid labile protective groups. The same conditions can be used to directly convert trityl-protected thiols into unsymmetrical disulfides or selenosulfides, and to cleave trityl resins in solid phase organic synthesis."}],"status":"public","publication":"Synthesis","publication_status":"published","date_updated":"2024-10-14T12:08:22Z","day":"01","oa_version":"None","article_processing_charge":"No","date_published":"2023-05-01T00:00:00Z","publisher":"Georg Thieme Verlag","volume":55,"intvolume":"        55","publication_identifier":{"issn":["0039-7881"],"eissn":["1437-210X"]},"extern":"1","quality_controlled":"1","month":"05","type":"journal_article","page":"1367-1374","citation":{"apa":"Murakami, S., Brudy, C., Bachmann, M., Takemoto, Y., &#38; Pieber, B. (2023). Photocatalytic cleavage of trityl protected thiols and alcohols. <i>Synthesis</i>. Georg Thieme Verlag. <a href=\"https://doi.org/10.1055/a-1979-5933\">https://doi.org/10.1055/a-1979-5933</a>","ama":"Murakami S, Brudy C, Bachmann M, Takemoto Y, Pieber B. Photocatalytic cleavage of trityl protected thiols and alcohols. <i>Synthesis</i>. 2023;55(09):1367-1374. doi:<a href=\"https://doi.org/10.1055/a-1979-5933\">10.1055/a-1979-5933</a>","mla":"Murakami, Sho, et al. “Photocatalytic Cleavage of Trityl Protected Thiols and Alcohols.” <i>Synthesis</i>, vol. 55, no. 09, Georg Thieme Verlag, 2023, pp. 1367–74, doi:<a href=\"https://doi.org/10.1055/a-1979-5933\">10.1055/a-1979-5933</a>.","short":"S. Murakami, C. Brudy, M. Bachmann, Y. Takemoto, B. Pieber, Synthesis 55 (2023) 1367–1374.","ieee":"S. Murakami, C. Brudy, M. Bachmann, Y. Takemoto, and B. Pieber, “Photocatalytic cleavage of trityl protected thiols and alcohols,” <i>Synthesis</i>, vol. 55, no. 09. Georg Thieme Verlag, pp. 1367–1374, 2023.","chicago":"Murakami, Sho, Cosima Brudy, Moritz Bachmann, Yoshiji Takemoto, and Bartholomäus Pieber. “Photocatalytic Cleavage of Trityl Protected Thiols and Alcohols.” <i>Synthesis</i>. Georg Thieme Verlag, 2023. <a href=\"https://doi.org/10.1055/a-1979-5933\">https://doi.org/10.1055/a-1979-5933</a>.","ista":"Murakami S, Brudy C, Bachmann M, Takemoto Y, Pieber B. 2023. Photocatalytic cleavage of trityl protected thiols and alcohols. Synthesis. 55(09), 1367–1374."},"article_type":"original","language":[{"iso":"eng"}],"keyword":["Organic Chemistry","Catalysis"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2023","author":[{"first_name":"Sho","full_name":"Murakami, Sho","last_name":"Murakami"},{"last_name":"Brudy","full_name":"Brudy, Cosima","first_name":"Cosima"},{"first_name":"Moritz","last_name":"Bachmann","full_name":"Bachmann, Moritz"},{"last_name":"Takemoto","full_name":"Takemoto, Yoshiji","first_name":"Yoshiji"},{"id":"93e5e5b2-0da6-11ed-8a41-af589a024726","last_name":"Pieber","full_name":"Pieber, Bartholomäus","first_name":"Bartholomäus","orcid":"0000-0001-8689-388X"}],"date_created":"2023-05-08T08:25:08Z","issue":"09","scopus_import":"1","_id":"12919","doi":"10.1055/a-1979-5933"}]