---
OA_type: closed access
_id: '21099'
abstract:
- lang: eng
  text: Quinoline‐based oligoamide foldamers have been identified as a potent class
    of ligands for G‐quadruplex DNA. Their helical structure is thought to target
    G‐quadruplex loops or grooves and not G‐tetrads. We report a co‐crystal structure
    of the antiparallel hairpin dimeric DNA G‐quadruplex (G4T4G4)2 with tetramer 1a
    helically folded oligo‐quinolinecarboxamide bearing cationic side chains—that
    is consistent with this hypothesis. Multivalent foldamer-DNA interactions that
    modify the packing of (G4T4G4)2 in the solid state are observed.
article_processing_charge: No
article_type: original
author:
- first_name: Pradeep K
  full_name: Mandal, Pradeep K
  id: 6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
  last_name: Mandal
  orcid: 0000-0001-5996-956X
- first_name: Benoît
  full_name: Baptiste, Benoît
  last_name: Baptiste
- first_name: Béatrice
  full_name: Langlois d'Estaintot, Béatrice
  last_name: Langlois d'Estaintot
- first_name: Brice
  full_name: Kauffmann, Brice
  last_name: Kauffmann
- first_name: Ivan
  full_name: Huc, Ivan
  last_name: Huc
citation:
  ama: Mandal PK, Baptiste B, Langlois d’Estaintot B, Kauffmann B, Huc I. Multivalent
    interactions between an aromatic helical foldamer and a DNA G‐quadruplex in the
    solid state. <i>ChemBioChem</i>. 2016;17(20):1911-1914. doi:<a href="https://doi.org/10.1002/cbic.201600281">10.1002/cbic.201600281</a>
  apa: Mandal, P. K., Baptiste, B., Langlois d’Estaintot, B., Kauffmann, B., &#38;
    Huc, I. (2016). Multivalent interactions between an aromatic helical foldamer
    and a DNA G‐quadruplex in the solid state. <i>ChemBioChem</i>. Wiley. <a href="https://doi.org/10.1002/cbic.201600281">https://doi.org/10.1002/cbic.201600281</a>
  chicago: Mandal, Pradeep K, Benoît Baptiste, Béatrice Langlois d’Estaintot, Brice
    Kauffmann, and Ivan Huc. “Multivalent Interactions between an Aromatic Helical
    Foldamer and a DNA G‐quadruplex in the Solid State.” <i>ChemBioChem</i>. Wiley,
    2016. <a href="https://doi.org/10.1002/cbic.201600281">https://doi.org/10.1002/cbic.201600281</a>.
  ieee: P. K. Mandal, B. Baptiste, B. Langlois d’Estaintot, B. Kauffmann, and I. Huc,
    “Multivalent interactions between an aromatic helical foldamer and a DNA G‐quadruplex
    in the solid state,” <i>ChemBioChem</i>, vol. 17, no. 20. Wiley, pp. 1911–1914,
    2016.
  ista: Mandal PK, Baptiste B, Langlois d’Estaintot B, Kauffmann B, Huc I. 2016. Multivalent
    interactions between an aromatic helical foldamer and a DNA G‐quadruplex in the
    solid state. ChemBioChem. 17(20), 1911–1914.
  mla: Mandal, Pradeep K., et al. “Multivalent Interactions between an Aromatic Helical
    Foldamer and a DNA G‐quadruplex in the Solid State.” <i>ChemBioChem</i>, vol.
    17, no. 20, Wiley, 2016, pp. 1911–14, doi:<a href="https://doi.org/10.1002/cbic.201600281">10.1002/cbic.201600281</a>.
  short: P.K. Mandal, B. Baptiste, B. Langlois d’Estaintot, B. Kauffmann, I. Huc,
    ChemBioChem 17 (2016) 1911–1914.
date_created: 2026-01-29T21:36:22Z
date_published: 2016-10-17T00:00:00Z
date_updated: 2026-02-23T09:21:50Z
day: '17'
doi: 10.1002/cbic.201600281
extern: '1'
fulldoi: https://doi.org/10.1002/cbic.201600281
has_accepted_license: '1'
intvolume: '        17'
issue: '20'
language:
- iso: eng
month: '10'
oa_version: None
page: 1911-1914
publication: ChemBioChem
publication_identifier:
  eissn:
  - 1439-7633
  issn:
  - 1439-4227
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Multivalent interactions between an aromatic helical foldamer and a DNA G‐quadruplex
  in the solid state
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2016'
...