[{"quality_controlled":"1","_id":"19475","publisher":"Oxford University Press","type":"journal_article","month":"05","title":"Netrin-DCC signaling regulates corpus callosum formation through attraction of pioneering axons and by modulating Slit2-mediated repulsion","status":"public","extern":"1","page":"1138-1151","citation":{"chicago":"Fothergill, Thomas, Amber-Lee S. Donahoo, Amelia M. Douglass, Oressia Zalucki, Jiajia Yuan, Tianzhi Shu, Geoffrey J. Goodhill, and Linda J. Richards. “Netrin-DCC Signaling Regulates Corpus Callosum Formation through Attraction of Pioneering Axons and by Modulating Slit2-Mediated Repulsion.” <i>Cerebral Cortex</i>. Oxford University Press, 2014. <a href=\"https://doi.org/10.1093/cercor/bhs395\">https://doi.org/10.1093/cercor/bhs395</a>.","mla":"Fothergill, Thomas, et al. “Netrin-DCC Signaling Regulates Corpus Callosum Formation through Attraction of Pioneering Axons and by Modulating Slit2-Mediated Repulsion.” <i>Cerebral Cortex</i>, vol. 24, no. 5, Oxford University Press, 2014, pp. 1138–51, doi:<a href=\"https://doi.org/10.1093/cercor/bhs395\">10.1093/cercor/bhs395</a>.","ama":"Fothergill T, Donahoo A-LS, Douglass AM, et al. Netrin-DCC signaling regulates corpus callosum formation through attraction of pioneering axons and by modulating Slit2-mediated repulsion. <i>Cerebral Cortex</i>. 2014;24(5):1138-1151. doi:<a href=\"https://doi.org/10.1093/cercor/bhs395\">10.1093/cercor/bhs395</a>","ieee":"T. Fothergill <i>et al.</i>, “Netrin-DCC signaling regulates corpus callosum formation through attraction of pioneering axons and by modulating Slit2-mediated repulsion,” <i>Cerebral Cortex</i>, vol. 24, no. 5. Oxford University Press, pp. 1138–1151, 2014.","apa":"Fothergill, T., Donahoo, A.-L. S., Douglass, A. M., Zalucki, O., Yuan, J., Shu, T., … Richards, L. J. (2014). Netrin-DCC signaling regulates corpus callosum formation through attraction of pioneering axons and by modulating Slit2-mediated repulsion. <i>Cerebral Cortex</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/cercor/bhs395\">https://doi.org/10.1093/cercor/bhs395</a>","ista":"Fothergill T, Donahoo A-LS, Douglass AM, Zalucki O, Yuan J, Shu T, Goodhill GJ, Richards LJ. 2014. Netrin-DCC signaling regulates corpus callosum formation through attraction of pioneering axons and by modulating Slit2-mediated repulsion. Cerebral Cortex. 24(5), 1138–1151.","short":"T. Fothergill, A.-L.S. Donahoo, A.M. Douglass, O. Zalucki, J. Yuan, T. Shu, G.J. Goodhill, L.J. Richards, Cerebral Cortex 24 (2014) 1138–1151."},"date_updated":"2025-07-10T11:51:43Z","article_type":"original","issue":"5","doi":"10.1093/cercor/bhs395","date_published":"2014-05-01T00:00:00Z","article_processing_charge":"No","publication":"Cerebral Cortex","abstract":[{"lang":"eng","text":"The left and right sides of the nervous system communicate via commissural axons that cross the midline during development using evolutionarily conserved molecules. These guidance cues have been particularly well studied in the mammalian spinal cord, but it remains unclear whether these guidance mechanisms for commissural axons are similar in the developing forebrain, in particular for the corpus callosum, the largest and most important commissure for cortical function. Here, we show that Netrin1 initially attracts callosal pioneering axons derived from the cingulate cortex, but surprisingly is not attractive for the neocortical callosal axons that make up the bulk of the projection. Instead, we show that Netrin-deleted in colorectal cancer signaling acts in a fundamentally different manner, to prevent the Slit2-mediated repulsion of precrossing axons thereby allowing them to approach and cross the midline. These results provide the first evidence for how callosal axons integrate multiple guidance cues to navigate the midline."}],"year":"2014","intvolume":"        24","volume":24,"oa_version":"None","date_created":"2025-04-03T12:31:58Z","publication_status":"published","OA_type":"closed access","author":[{"full_name":"Fothergill, Thomas","first_name":"Thomas","last_name":"Fothergill"},{"first_name":"Amber-Lee S.","full_name":"Donahoo, Amber-Lee S.","last_name":"Donahoo"},{"last_name":"Douglass","full_name":"Douglass, Amelia May Barnett","first_name":"Amelia May Barnett","id":"de5f6fda-80fb-11ef-996f-a8c4ecd8e289","orcid":"0000-0001-5398-6473"},{"first_name":"Oressia","full_name":"Zalucki, Oressia","last_name":"Zalucki"},{"first_name":"Jiajia","full_name":"Yuan, Jiajia","last_name":"Yuan"},{"full_name":"Shu, Tianzhi","first_name":"Tianzhi","last_name":"Shu"},{"full_name":"Goodhill, Geoffrey J.","first_name":"Geoffrey J.","last_name":"Goodhill"},{"last_name":"Richards","full_name":"Richards, Linda J.","first_name":"Linda J."}],"scopus_import":"1","external_id":{"pmid":["23302812 "]},"language":[{"iso":"eng"}],"day":"01","pmid":1,"publication_identifier":{"eissn":["1460-2199"],"issn":["1047-3211"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"publist_id":"4264","scopus_import":"1","external_id":{"pmid":["12902392"]},"author":[{"last_name":"López Bendito","full_name":"López Bendito, Guillermina","first_name":"Guillermina"},{"last_name":"Luján","full_name":"Luján, Rafael","first_name":"Rafael"},{"first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Ganter, Paul","first_name":"Paul","last_name":"Ganter"},{"first_name":"Ole","full_name":"Paulsen, Ole","last_name":"Paulsen"},{"last_name":"Molnár","first_name":"Zoltán","full_name":"Molnár, Zoltán"}],"publication_status":"published","OA_type":"closed access","publication_identifier":{"issn":["1047-3211"],"eissn":["1460-2199"]},"pmid":1,"day":"01","language":[{"iso":"eng"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","abstract":[{"lang":"eng","text":"To better understand the role of neurotransmitter receptors in neuronal differentiation and maturation a detailed knowledge of their identity, location and function in the plasma membrane of specific neuronal populations during development is required. Combining pre-embedding immunocytochemistry with cell tracking in embryonic brain slice cultures we show that virtually all neurons (∼98%) migrating through the lower intermediate zone (LIZ) on their way from the medial ganglionic eminence to the cerebral cortex, express GABA BR1. Blockade of GABABRs with a specific antagonist, CGP52432, resulted in a concentration-dependent accumulation of these tangentially migrating neurons in the ventricular/subventricular zones (VZ/SVZ) of the cortex and fewer cells were observed in the cortical plate/marginal zone (CP/MZ) and LIZ. Moreover, they had significantly shorter leading processes compared with similar migrating cells in control slices. Electrophysiological recording in LIZ and CP cells revealed no direct effect of either CGP52432 or the GABABR agonist, baclofen, on resting membrane properties suggesting that the effect of CGP52432 on migration might be mediated through a metabotropic action or the regulation of release of factors controlling migration. These results suggest that GABABRs have an important modulatory role in the migration of cortical interneurons."}],"article_processing_charge":"No","publication":"Cerebral Cortex","date_published":"2003-09-01T00:00:00Z","doi":"10.1093/cercor/13.9.932","intvolume":"        13","year":"2003","volume":13,"oa_version":"None","date_created":"2018-12-11T11:58:47Z","page":"932 - 942","extern":"1","date_updated":"2026-05-22T09:53:10Z","citation":{"apa":"López Bendito, G., Luján, R., Shigemoto, R., Ganter, P., Paulsen, O., &#38; Molnár, Z. (2003). Blockade of GABAB receptors alters the tangential migration of cortical neurons. <i>Cerebral Cortex</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/cercor/13.9.932\">https://doi.org/10.1093/cercor/13.9.932</a>","ieee":"G. López Bendito, R. Luján, R. Shigemoto, P. Ganter, O. Paulsen, and Z. Molnár, “Blockade of GABAB receptors alters the tangential migration of cortical neurons,” <i>Cerebral Cortex</i>, vol. 13, no. 9. Oxford University Press, pp. 932–942, 2003.","short":"G. López Bendito, R. Luján, R. Shigemoto, P. Ganter, O. Paulsen, Z. Molnár, Cerebral Cortex 13 (2003) 932–942.","ista":"López Bendito G, Luján R, Shigemoto R, Ganter P, Paulsen O, Molnár Z. 2003. Blockade of GABAB receptors alters the tangential migration of cortical neurons. Cerebral Cortex. 13(9), 932–942.","chicago":"López Bendito, Guillermina, Rafael Luján, Ryuichi Shigemoto, Paul Ganter, Ole Paulsen, and Zoltán Molnár. “Blockade of GABAB Receptors Alters the Tangential Migration of Cortical Neurons.” <i>Cerebral Cortex</i>. Oxford University Press, 2003. <a href=\"https://doi.org/10.1093/cercor/13.9.932\">https://doi.org/10.1093/cercor/13.9.932</a>.","mla":"López Bendito, Guillermina, et al. “Blockade of GABAB Receptors Alters the Tangential Migration of Cortical Neurons.” <i>Cerebral Cortex</i>, vol. 13, no. 9, Oxford University Press, 2003, pp. 932–42, doi:<a href=\"https://doi.org/10.1093/cercor/13.9.932\">10.1093/cercor/13.9.932</a>.","ama":"López Bendito G, Luján R, Shigemoto R, Ganter P, Paulsen O, Molnár Z. Blockade of GABAB receptors alters the tangential migration of cortical neurons. <i>Cerebral Cortex</i>. 2003;13(9):932-942. doi:<a href=\"https://doi.org/10.1093/cercor/13.9.932\">10.1093/cercor/13.9.932</a>"},"issue":"9","article_type":"original","quality_controlled":"1","_id":"2634","title":"Blockade of GABAB receptors alters the tangential migration of cortical neurons","status":"public","month":"09","type":"journal_article","publisher":"Oxford University Press"}]