[{"volume":605,"external_id":{"pmid":["35508781"],"arxiv":["2205.02278"]},"keyword":["Multidisciplinary"],"language":[{"iso":"eng"}],"oa_version":"Preprint","intvolume":"       605","date_published":"2022-05-04T00:00:00Z","type":"journal_article","quality_controlled":"1","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2205.02278"}],"month":"05","doi":"10.1038/s41586-022-04551-1","scopus_import":"1","pmid":1,"status":"public","issue":"7908","article_type":"original","citation":{"ieee":"K. B. Burdge <i>et al.</i>, “A 62-minute orbital period black widow binary in a wide hierarchical triple,” <i>Nature</i>, vol. 605, no. 7908. Springer Nature, pp. 41–45, 2022.","mla":"Burdge, Kevin B., et al. “A 62-Minute Orbital Period Black Widow Binary in a Wide Hierarchical Triple.” <i>Nature</i>, vol. 605, no. 7908, Springer Nature, 2022, pp. 41–45, doi:<a href=\"https://doi.org/10.1038/s41586-022-04551-1\">10.1038/s41586-022-04551-1</a>.","apa":"Burdge, K. B., Marsh, T. R., Fuller, J., Bellm, E. C., Caiazzo, I., Chakrabarty, D., … Prince, T. A. (2022). A 62-minute orbital period black widow binary in a wide hierarchical triple. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-022-04551-1\">https://doi.org/10.1038/s41586-022-04551-1</a>","ama":"Burdge KB, Marsh TR, Fuller J, et al. A 62-minute orbital period black widow binary in a wide hierarchical triple. <i>Nature</i>. 2022;605(7908):41-45. doi:<a href=\"https://doi.org/10.1038/s41586-022-04551-1\">10.1038/s41586-022-04551-1</a>","ista":"Burdge KB, Marsh TR, Fuller J, Bellm EC, Caiazzo I, Chakrabarty D, Coughlin MW, De K, Dhillon VS, Graham MJ, Rodríguez-Gil P, Jaodand AD, Kaplan DL, Kara E, Kong AKH, Kulkarni SR, Li K-L, Littlefair SP, Majid WA, Mróz P, Pearlman AB, Phinney ES, Roestel J van, Simcoe RA, Andreoni I, Drake AJ, Dekany RG, Duev DA, Kool EC, Mahabal AA, Medford MS, Riddle R, Prince TA. 2022. A 62-minute orbital period black widow binary in a wide hierarchical triple. Nature. 605(7908), 41–45.","short":"K.B. Burdge, T.R. Marsh, J. Fuller, E.C. Bellm, I. Caiazzo, D. Chakrabarty, M.W. Coughlin, K. De, V.S. Dhillon, M.J. Graham, P. Rodríguez-Gil, A.D. Jaodand, D.L. Kaplan, E. Kara, A.K.H. Kong, S.R. Kulkarni, K.-L. Li, S.P. Littlefair, W.A. Majid, P. Mróz, A.B. Pearlman, E.S. Phinney, J. van Roestel, R.A. Simcoe, I. Andreoni, A.J. Drake, R.G. Dekany, D.A. Duev, E.C. Kool, A.A. Mahabal, M.S. Medford, R. Riddle, T.A. Prince, Nature 605 (2022) 41–45.","chicago":"Burdge, Kevin B., Thomas R. Marsh, Jim Fuller, Eric C. Bellm, Ilaria Caiazzo, Deepto Chakrabarty, Michael W. Coughlin, et al. “A 62-Minute Orbital Period Black Widow Binary in a Wide Hierarchical Triple.” <i>Nature</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41586-022-04551-1\">https://doi.org/10.1038/s41586-022-04551-1</a>."},"oa":1,"fulldoi":"https://doi.org/10.1038/s41586-022-04551-1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Springer Nature","date_created":"2024-03-26T10:29:26Z","arxiv":1,"date_updated":"2024-04-02T07:26:19Z","extern":"1","publication_status":"published","day":"04","article_processing_charge":"No","publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"_id":"15211","year":"2022","abstract":[{"lang":"eng","text":"Over a dozen millisecond pulsars are ablating low-mass companions in close binary systems. In the original ‘black widow’, the eight-hour orbital period eclipsing pulsar PSR J1959+2048 (PSR B1957+20)1, high-energy emission originating from the pulsar2 is irradiating and may eventually destroy3 a low-mass companion. These systems are not only physical laboratories that reveal the interesting results of exposing a close companion star to the relativistic energy output of a pulsar, but are also believed to harbour some of the most massive neutron stars4, allowing for robust tests of the neutron star equation of state. Here we report observations of ZTF J1406+1222, a wide hierarchical triple hosting a 62-minute orbital period black widow candidate, the optical flux of which varies by a factor of more than ten. ZTF J1406+1222 pushes the boundaries of evolutionary models5, falling below the 80-minute minimum orbital period of hydrogen-rich systems. The wide tertiary companion is a rare low-metallicity cool subdwarf star, and the system has a Galactic halo orbit consistent with passing near the Galactic Centre, making it a probe of formation channels, neutron star kick physics6 and binary evolution."}],"page":"41-45","publication":"Nature","author":[{"full_name":"Burdge, Kevin B.","last_name":"Burdge","first_name":"Kevin B."},{"first_name":"Thomas R.","last_name":"Marsh","full_name":"Marsh, Thomas R."},{"first_name":"Jim","last_name":"Fuller","full_name":"Fuller, Jim"},{"last_name":"Bellm","full_name":"Bellm, Eric C.","first_name":"Eric C."},{"full_name":"Caiazzo, Ilaria","last_name":"Caiazzo","orcid":"0000-0002-4770-5388","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d","first_name":"Ilaria"},{"first_name":"Deepto","last_name":"Chakrabarty","full_name":"Chakrabarty, Deepto"},{"full_name":"Coughlin, Michael W.","last_name":"Coughlin","first_name":"Michael W."},{"first_name":"Kishalay","last_name":"De","full_name":"De, Kishalay"},{"last_name":"Dhillon","full_name":"Dhillon, V. S.","first_name":"V. S."},{"first_name":"Matthew J.","full_name":"Graham, Matthew J.","last_name":"Graham"},{"full_name":"Rodríguez-Gil, Pablo","last_name":"Rodríguez-Gil","first_name":"Pablo"},{"last_name":"Jaodand","full_name":"Jaodand, Amruta D.","first_name":"Amruta D."},{"last_name":"Kaplan","full_name":"Kaplan, David L.","first_name":"David L."},{"first_name":"Erin","full_name":"Kara, Erin","last_name":"Kara"},{"full_name":"Kong, Albert K. H.","last_name":"Kong","first_name":"Albert K. H."},{"last_name":"Kulkarni","full_name":"Kulkarni, S. R.","first_name":"S. R."},{"last_name":"Li","full_name":"Li, Kwan-Lok","first_name":"Kwan-Lok"},{"last_name":"Littlefair","full_name":"Littlefair, S. P.","first_name":"S. P."},{"first_name":"Walid A.","last_name":"Majid","full_name":"Majid, Walid A."},{"last_name":"Mróz","full_name":"Mróz, Przemek","first_name":"Przemek"},{"first_name":"Aaron B.","last_name":"Pearlman","full_name":"Pearlman, Aaron B."},{"first_name":"E. S.","full_name":"Phinney, E. S.","last_name":"Phinney"},{"last_name":"Roestel","full_name":"Roestel, Jan van","first_name":"Jan van"},{"full_name":"Simcoe, Robert A.","last_name":"Simcoe","first_name":"Robert A."},{"first_name":"Igor","last_name":"Andreoni","full_name":"Andreoni, Igor"},{"last_name":"Drake","full_name":"Drake, Andrew J.","first_name":"Andrew J."},{"last_name":"Dekany","full_name":"Dekany, Richard G.","first_name":"Richard G."},{"last_name":"Duev","full_name":"Duev, Dmitry A.","first_name":"Dmitry A."},{"first_name":"Erik C.","last_name":"Kool","full_name":"Kool, Erik C."},{"full_name":"Mahabal, Ashish A.","last_name":"Mahabal","first_name":"Ashish A."},{"first_name":"Michael S.","full_name":"Medford, Michael S.","last_name":"Medford"},{"first_name":"Reed","last_name":"Riddle","full_name":"Riddle, Reed"},{"first_name":"Thomas A.","full_name":"Prince, Thomas A.","last_name":"Prince"}],"title":"A 62-minute orbital period black widow binary in a wide hierarchical triple"},{"article_type":"original","issue":"7927","file_date_updated":"2023-11-02T17:12:37Z","citation":{"chicago":"Friml, Jiří, Michelle C Gallei, Zuzana Gelová, Alexander J Johnson, Ewa Mazur, Aline Monzer, Lesia Rodriguez Solovey, et al. “ABP1–TMK Auxin Perception for Global Phosphorylation and Auxin Canalization.” <i>Nature</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41586-022-05187-x\">https://doi.org/10.1038/s41586-022-05187-x</a>.","short":"J. Friml, M.C. Gallei, Z. Gelová, A.J. Johnson, E. Mazur, A. Monzer, L. Rodriguez Solovey, M. Roosjen, I. Verstraeten, B.D. Živanović, M. Zou, L. Fiedler, C. Giannini, P. Grones, M. Hrtyan, W. Kaufmann, A. Kuhn, M. Narasimhan, M. Randuch, N. Rýdza, K. Takahashi, S. Tan, A. Teplova, T. Kinoshita, D. Weijers, H. Rakusová, Nature 609 (2022) 575–581.","ieee":"J. Friml <i>et al.</i>, “ABP1–TMK auxin perception for global phosphorylation and auxin canalization,” <i>Nature</i>, vol. 609, no. 7927. Springer Nature, pp. 575–581, 2022.","apa":"Friml, J., Gallei, M. C., Gelová, Z., Johnson, A. J., Mazur, E., Monzer, A., … Rakusová, H. (2022). ABP1–TMK auxin perception for global phosphorylation and auxin canalization. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-022-05187-x\">https://doi.org/10.1038/s41586-022-05187-x</a>","ama":"Friml J, Gallei MC, Gelová Z, et al. ABP1–TMK auxin perception for global phosphorylation and auxin canalization. <i>Nature</i>. 2022;609(7927):575-581. doi:<a href=\"https://doi.org/10.1038/s41586-022-05187-x\">10.1038/s41586-022-05187-x</a>","mla":"Friml, Jiří, et al. “ABP1–TMK Auxin Perception for Global Phosphorylation and Auxin Canalization.” <i>Nature</i>, vol. 609, no. 7927, Springer Nature, 2022, pp. 575–81, doi:<a href=\"https://doi.org/10.1038/s41586-022-05187-x\">10.1038/s41586-022-05187-x</a>.","ista":"Friml J, Gallei MC, Gelová Z, Johnson AJ, Mazur E, Monzer A, Rodriguez Solovey L, Roosjen M, Verstraeten I, Živanović BD, Zou M, Fiedler L, Giannini C, Grones P, Hrtyan M, Kaufmann W, Kuhn A, Narasimhan M, Randuch M, Rýdza N, Takahashi K, Tan S, Teplova A, Kinoshita T, Weijers D, Rakusová H. 2022. ABP1–TMK auxin perception for global phosphorylation and auxin canalization. Nature. 609(7927), 575–581."},"oa":1,"fulldoi":"https://doi.org/10.1038/s41586-022-05187-x","acknowledgement":"We acknowledge K. Kubiasová for excellent technical assistance, J. Neuhold, A. Lehner and A. Sedivy for technical assistance with protein production and purification at Vienna Biocenter Core Facilities; Creoptix for performing GCI; and the Bioimaging, Electron Microscopy and Life Science Facilities at ISTA, the Plant Sciences Core Facility of CEITEC Masaryk University, the Core Facility CELLIM (MEYS CR, LM2018129 Czech-BioImaging) and J. Sprakel for their assistance. J.F. is grateful to R. Napier for many insightful suggestions and support. We thank all past and present members of the Friml group for their support and for other contributions to this effort to clarify the controversial role of ABP1 over the past seven years. The project received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement no. 742985 to J.F. and 833867 to D.W.); the Austrian Science Fund (FWF; P29988 to J.F.); the Netherlands Organization for Scientific Research (NWO; VICI grant 865.14.001 to D.W. and VENI grant VI.Veni.212.003 to A.K.); the Ministry of Education, Science and Technological Development of the Republic of Serbia (contract no. 451-03-68/2022-14/200053 to B.D.Ž.); and the MEXT/JSPS KAKENHI to K.T. (20K06685) and T.K. (20H05687 and 20H05910).","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2023-01-16T10:04:48Z","isi":1,"publisher":"Springer Nature","date_updated":"2026-10-02T22:30:03Z","ec_funded":1,"article_processing_charge":"No","day":"15","publication_status":"published","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"year":"2022","_id":"12291","page":"575-581","abstract":[{"lang":"eng","text":"The phytohormone auxin triggers transcriptional reprogramming through a well-characterized perception machinery in the nucleus. By contrast, mechanisms that underlie fast effects of auxin, such as the regulation of ion fluxes, rapid phosphorylation of proteins or auxin feedback on its transport, remain unclear1,2,3. Whether auxin-binding protein 1 (ABP1) is an auxin receptor has been a source of debate for decades1,4. Here we show that a fraction of Arabidopsis thaliana ABP1 is secreted and binds auxin specifically at an acidic pH that is typical of the apoplast. ABP1 and its plasma-membrane-localized partner, transmembrane kinase 1 (TMK1), are required for the auxin-induced ultrafast global phospho-response and for downstream processes that include the activation of H+-ATPase and accelerated cytoplasmic streaming. abp1 and tmk mutants cannot establish auxin-transporting channels and show defective auxin-induced vasculature formation and regeneration. An ABP1(M2X) variant that lacks the capacity to bind auxin is unable to complement these defects in abp1 mutants. These data indicate that ABP1 is the auxin receptor for TMK1-based cell-surface signalling, which mediates the global phospho-response and auxin canalization."}],"author":[{"first_name":"Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","last_name":"Friml","full_name":"Friml, Jiří"},{"full_name":"Gallei, Michelle C","last_name":"Gallei","orcid":"0000-0003-1286-7368","id":"35A03822-F248-11E8-B48F-1D18A9856A87","first_name":"Michelle C"},{"full_name":"Gelová, Zuzana","last_name":"Gelová","orcid":"0000-0003-4783-1752","id":"0AE74790-0E0B-11E9-ABC7-1ACFE5697425","first_name":"Zuzana"},{"full_name":"Johnson, Alexander J","last_name":"Johnson","first_name":"Alexander J","id":"46A62C3A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2739-8843"},{"last_name":"Mazur","full_name":"Mazur, Ewa","first_name":"Ewa"},{"first_name":"Aline","id":"2DB5D88C-D7B3-11E9-B8FD-7907E6697425","last_name":"Monzer","full_name":"Monzer, Aline"},{"last_name":"Rodriguez Solovey","full_name":"Rodriguez Solovey, Lesia","first_name":"Lesia","id":"3922B506-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7244-7237"},{"first_name":"Mark","full_name":"Roosjen, Mark","last_name":"Roosjen"},{"orcid":"0000-0001-7241-2328","id":"362BF7FE-F248-11E8-B48F-1D18A9856A87","first_name":"Inge","last_name":"Verstraeten","full_name":"Verstraeten, Inge"},{"full_name":"Živanović, Branka D.","last_name":"Živanović","first_name":"Branka D."},{"first_name":"Minxia","id":"5c243f41-03f3-11ec-841c-96faf48a7ef9","full_name":"Zou, Minxia","last_name":"Zou"},{"id":"7c417475-8972-11ed-ae7b-8b674ca26986","first_name":"Lukas","full_name":"Fiedler, Lukas","last_name":"Fiedler"},{"first_name":"Caterina","id":"e3fdddd5-f6e0-11ea-865d-ca99ee6367f4","last_name":"Giannini","full_name":"Giannini, Caterina"},{"first_name":"Peter","full_name":"Grones, Peter","last_name":"Grones"},{"last_name":"Hrtyan","full_name":"Hrtyan, Mónika","first_name":"Mónika","id":"45A71A74-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0001-9735-5315","id":"3F99E422-F248-11E8-B48F-1D18A9856A87","first_name":"Walter","last_name":"Kaufmann","full_name":"Kaufmann, Walter"},{"first_name":"Andre","full_name":"Kuhn, Andre","last_name":"Kuhn"},{"full_name":"Narasimhan, Madhumitha","last_name":"Narasimhan","id":"44BF24D0-F248-11E8-B48F-1D18A9856A87","first_name":"Madhumitha","orcid":"0000-0002-8600-0671"},{"first_name":"Marek","id":"6ac4636d-15b2-11ec-abd3-fb8df79972ae","full_name":"Randuch, Marek","last_name":"Randuch"},{"last_name":"Rýdza","full_name":"Rýdza, Nikola","first_name":"Nikola"},{"first_name":"Koji","last_name":"Takahashi","full_name":"Takahashi, Koji"},{"orcid":"0000-0002-0471-8285","first_name":"Shutang","id":"2DE75584-F248-11E8-B48F-1D18A9856A87","last_name":"Tan","full_name":"Tan, Shutang"},{"first_name":"Anastasiia","id":"e3736151-106c-11ec-b916-c2558e2762c6","last_name":"Teplova","full_name":"Teplova, Anastasiia"},{"first_name":"Toshinori","last_name":"Kinoshita","full_name":"Kinoshita, Toshinori"},{"full_name":"Weijers, Dolf","last_name":"Weijers","first_name":"Dolf"},{"first_name":"Hana","full_name":"Rakusová, Hana","last_name":"Rakusová"}],"title":"ABP1–TMK auxin perception for global phosphorylation and auxin canalization","publication":"Nature","language":[{"iso":"eng"}],"volume":609,"external_id":{"pmid":["36071161"],"isi":["000851357500002"]},"oa_version":"Submitted Version","type":"journal_article","date_published":"2022-09-15T00:00:00Z","intvolume":"       609","acknowledged_ssus":[{"_id":"Bio"},{"_id":"EM-Fac"},{"_id":"LifeSc"}],"file":[{"date_updated":"2023-11-02T17:12:37Z","file_name":"Friml Nature 2022_merged.pdf","content_type":"application/pdf","creator":"amally","checksum":"a6055c606aefb900bf62ae3e7d15f921","file_size":79774945,"relation":"main_file","access_level":"open_access","file_id":"14483","success":1,"date_created":"2023-11-02T17:12:37Z"}],"ddc":["580"],"quality_controlled":"1","month":"09","related_material":{"record":[{"status":"public","id":"19395","relation":"dissertation_contains"},{"id":"20364","relation":"dissertation_contains","status":"public"}]},"doi":"10.1038/s41586-022-05187-x","scopus_import":"1","pmid":1,"corr_author":"1","status":"public","has_accepted_license":"1","department":[{"_id":"JiFr"},{"_id":"GradSch"},{"_id":"EvBe"},{"_id":"EM-Fac"}],"project":[{"name":"Tracing Evolution of Auxin Transport and Polarity in Plants","grant_number":"742985","_id":"261099A6-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"call_identifier":"FWF","grant_number":"P29988","_id":"262EF96E-B435-11E9-9278-68D0E5697425","name":"RNA-directed DNA methylation in plant development"}]},{"scopus_import":"1","pmid":1,"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"12781"}],"link":[{"url":"https://doi.org/10.1038/s41586-022-05457-8","relation":"erratum"},{"url":"https://ista.ac.at/en/news/proton-dominos-kick-off-life/","relation":"press_release","description":"News on ISTA website"}]},"doi":"10.1038/s41586-022-05199-7","has_accepted_license":"1","status":"public","department":[{"_id":"LeSa"}],"project":[{"grant_number":"25541","_id":"238A0A5A-32DE-11EA-91FC-C7463DDC885E","name":"Structural characterization of E. coli complex I: an important mechanistic model"},{"call_identifier":"H2020","grant_number":"101020697","_id":"627abdeb-2b32-11ec-9570-ec31a97243d3","name":"Structure and mechanism of respiratory chain molecular machines"}],"corr_author":"1","oa_version":"Submitted Version","type":"journal_article","date_published":"2022-09-22T00:00:00Z","acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"LifeSc"},{"_id":"ScienComp"}],"intvolume":"       609","keyword":["Multidisciplinary"],"language":[{"iso":"eng"}],"volume":609,"external_id":{"pmid":["36104567"],"isi":["000854788200001"]},"month":"09","file":[{"date_updated":"2023-05-30T17:05:31Z","file_name":"EcCxI_manuscript_rev3_noSI_updated_withFigs_opt.pdf","content_type":"application/pdf","creator":"lsazanov","checksum":"d42a93e24f59e883ef0b5429832391d0","file_size":1425655,"relation":"main_file","access_level":"open_access","file_id":"13104","success":1,"date_created":"2023-05-30T17:05:31Z"},{"relation":"main_file","file_size":9842513,"date_created":"2023-05-30T17:07:05Z","success":1,"file_id":"13105","access_level":"open_access","file_name":"EcCxI_manuscript_rev3_SI_All_opt_upd.pdf","date_updated":"2023-05-30T17:07:05Z","checksum":"5422bc0a73b3daadafa262c7ea6deae3","creator":"lsazanov","content_type":"application/pdf"}],"ddc":["572"],"quality_controlled":"1","ec_funded":1,"day":"22","article_processing_charge":"No","publication_status":"published","date_updated":"2026-10-02T22:30:11Z","page":"808-814","abstract":[{"lang":"eng","text":"Complex I is the first enzyme in the respiratory chain, which is responsible for energy production in mitochondria and bacteria1. Complex I couples the transfer of two electrons from NADH to quinone and the translocation of four protons across the membrane2, but the coupling mechanism remains contentious. Here we present cryo-electron microscopy structures of Escherichia coli complex I (EcCI) in different redox states, including catalytic turnover. EcCI exists mostly in the open state, in which the quinone cavity is exposed to the cytosol, allowing access for water molecules, which enable quinone movements. Unlike the mammalian paralogues3, EcCI can convert to the closed state only during turnover, showing that closed and open states are genuine turnover intermediates. The open-to-closed transition results in the tightly engulfed quinone cavity being connected to the central axis of the membrane arm, a source of substrate protons. Consistently, the proportion of the closed state increases with increasing pH. We propose a detailed but straightforward and robust mechanism comprising a ‘domino effect’ series of proton transfers and electrostatic interactions: the forward wave (‘dominoes stacking’) primes the pump, and the reverse wave (‘dominoes falling’) results in the ejection of all pumped protons from the distal subunit NuoL. This mechanism explains why protons exit exclusively from the NuoL subunit and is supported by our mutagenesis data. We contend that this is a universal coupling mechanism of complex I and related enzymes."}],"publication":"Nature","title":"A universal coupling mechanism of respiratory complex I","author":[{"orcid":"0000-0001-9523-9089","first_name":"Vladyslav","id":"4D62F2A6-F248-11E8-B48F-1D18A9856A87","last_name":"Kravchuk","full_name":"Kravchuk, Vladyslav"},{"full_name":"Petrova, Olga","last_name":"Petrova","id":"5D8C9660-5D49-11EA-8188-567B3DDC885E","first_name":"Olga"},{"first_name":"Domen","id":"37233050-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6018-3422","last_name":"Kampjut","full_name":"Kampjut, Domen"},{"first_name":"Anna","full_name":"Wojciechowska-Bason, Anna","last_name":"Wojciechowska-Bason"},{"first_name":"Zara","full_name":"Breese, Zara","last_name":"Breese"},{"full_name":"Sazanov, Leonid A","last_name":"Sazanov","first_name":"Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0977-7989"}],"publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"_id":"12138","year":"2022","file_date_updated":"2023-05-30T17:07:05Z","citation":{"chicago":"Kravchuk, Vladyslav, Olga Petrova, Domen Kampjut, Anna Wojciechowska-Bason, Zara Breese, and Leonid A Sazanov. “A Universal Coupling Mechanism of Respiratory Complex I.” <i>Nature</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41586-022-05199-7\">https://doi.org/10.1038/s41586-022-05199-7</a>.","short":"V. Kravchuk, O. Petrova, D. Kampjut, A. Wojciechowska-Bason, Z. Breese, L.A. Sazanov, Nature 609 (2022) 808–814.","ama":"Kravchuk V, Petrova O, Kampjut D, Wojciechowska-Bason A, Breese Z, Sazanov LA. A universal coupling mechanism of respiratory complex I. <i>Nature</i>. 2022;609(7928):808-814. doi:<a href=\"https://doi.org/10.1038/s41586-022-05199-7\">10.1038/s41586-022-05199-7</a>","mla":"Kravchuk, Vladyslav, et al. “A Universal Coupling Mechanism of Respiratory Complex I.” <i>Nature</i>, vol. 609, no. 7928, Springer Nature, 2022, pp. 808–14, doi:<a href=\"https://doi.org/10.1038/s41586-022-05199-7\">10.1038/s41586-022-05199-7</a>.","apa":"Kravchuk, V., Petrova, O., Kampjut, D., Wojciechowska-Bason, A., Breese, Z., &#38; Sazanov, L. A. (2022). A universal coupling mechanism of respiratory complex I. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-022-05199-7\">https://doi.org/10.1038/s41586-022-05199-7</a>","ista":"Kravchuk V, Petrova O, Kampjut D, Wojciechowska-Bason A, Breese Z, Sazanov LA. 2022. A universal coupling mechanism of respiratory complex I. Nature. 609(7928), 808–814.","ieee":"V. Kravchuk, O. Petrova, D. Kampjut, A. Wojciechowska-Bason, Z. Breese, and L. A. Sazanov, “A universal coupling mechanism of respiratory complex I,” <i>Nature</i>, vol. 609, no. 7928. Springer Nature, pp. 808–814, 2022."},"oa":1,"article_type":"original","issue":"7928","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_created":"2023-01-12T12:04:33Z","publisher":"Springer Nature","isi":1,"fulldoi":"https://doi.org/10.1038/s41586-022-05199-7","acknowledgement":"This research was supported by the Scientific Service Units (SSU) of IST Austria through resources provided by the Electron Microscopy Facility (EMF), the Life Science Facility (LSF) and the IST high-performance computing cluster. We thank V.-V. Hodirnau from IST Austria EMF, M. Babiak from CEITEC for assistance with collecting cryo-EM data and A. Charnagalov for the assistance with protein purification. V.K. was a recipient of a DOC Fellowship of the Austrian Academy of Sciences at the Institute of Science and Technology, Austria. V.K. and O.P. are funded by the ERC Advanced Grant 101020697 RESPICHAIN to L.S. This work was also supported by the Medical Research Council (UK)."},{"citation":{"ieee":"R. S. Grand <i>et al.</i>, “BANP opens chromatin and activates CpG-island-regulated genes,” <i>Nature</i>, vol. 596. Springer Nature, pp. 133–137, 2021.","ista":"Grand RS, Burger L, Gräwe C, Michael AK, Isbel L, Hess D, Hoerner L, Iesmantavicius V, Durdu S, Pregnolato M, Krebs AR, Smallwood SA, Thomä N, Vermeulen M, Schübeler D. 2021. BANP opens chromatin and activates CpG-island-regulated genes. Nature. 596, 133–137.","mla":"Grand, Ralph S., et al. “BANP Opens Chromatin and Activates CpG-Island-Regulated Genes.” <i>Nature</i>, vol. 596, Springer Nature, 2021, pp. 133–37, doi:<a href=\"https://doi.org/10.1038/s41586-021-03689-8\">10.1038/s41586-021-03689-8</a>.","ama":"Grand RS, Burger L, Gräwe C, et al. BANP opens chromatin and activates CpG-island-regulated genes. <i>Nature</i>. 2021;596:133-137. doi:<a href=\"https://doi.org/10.1038/s41586-021-03689-8\">10.1038/s41586-021-03689-8</a>","apa":"Grand, R. S., Burger, L., Gräwe, C., Michael, A. K., Isbel, L., Hess, D., … Schübeler, D. (2021). BANP opens chromatin and activates CpG-island-regulated genes. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-021-03689-8\">https://doi.org/10.1038/s41586-021-03689-8</a>","short":"R.S. Grand, L. Burger, C. Gräwe, A.K. Michael, L. Isbel, D. Hess, L. Hoerner, V. Iesmantavicius, S. Durdu, M. Pregnolato, A.R. Krebs, S.A. Smallwood, N. Thomä, M. Vermeulen, D. Schübeler, Nature 596 (2021) 133–137.","chicago":"Grand, Ralph S., Lukas Burger, Cathrin Gräwe, Alicia K. Michael, Luke Isbel, Daniel Hess, Leslie Hoerner, et al. “BANP Opens Chromatin and Activates CpG-Island-Regulated Genes.” <i>Nature</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41586-021-03689-8\">https://doi.org/10.1038/s41586-021-03689-8</a>."},"oa_version":"None","intvolume":"       596","date_published":"2021-08-05T00:00:00Z","type":"journal_article","volume":596,"language":[{"iso":"eng"}],"article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"08","publisher":"Springer Nature","date_created":"2024-03-21T07:53:48Z","fulldoi":"https://doi.org/10.1038/s41586-021-03689-8","quality_controlled":"1","extern":"1","scopus_import":"1","publication_status":"published","article_processing_charge":"No","day":"05","date_updated":"2024-03-25T12:34:31Z","doi":"10.1038/s41586-021-03689-8","abstract":[{"lang":"eng","text":"The majority of gene transcripts generated by RNA polymerase II in mammalian genomes initiate at CpG island (CGI) promoters1,2, yet our understanding of their regulation remains limited. This is in part due to the incomplete information that we have on transcription factors, their DNA-binding motifs and which genomic binding sites are functional in any given cell type3,4,5. In addition, there are orphan motifs without known binders, such as the CGCG element, which is associated with highly expressed genes across human tissues and enriched near the transcription start site of a subset of CGI promoters6,7,8. Here we combine single-molecule footprinting with interaction proteomics to identify BTG3-associated nuclear protein (BANP) as the transcription factor that binds this element in the mouse and human genome. We show that BANP is a strong CGI activator that controls essential metabolic genes in pluripotent stem and terminally differentiated neuronal cells. BANP binding is repelled by DNA methylation of its motif in vitro and in vivo, which epigenetically restricts most binding to CGIs and accounts for differential binding at aberrantly methylated CGI promoters in cancer cells. Upon binding to an unmethylated motif, BANP opens chromatin and phases nucleosomes. These findings establish BANP as a critical activator of a set of essential genes and suggest a model in which the activity of CGI promoters relies on methylation-sensitive transcription factors that are capable of chromatin opening."}],"status":"public","page":"133-137","publication":"Nature","title":"BANP opens chromatin and activates CpG-island-regulated genes","author":[{"last_name":"Grand","full_name":"Grand, Ralph S.","first_name":"Ralph S."},{"first_name":"Lukas","full_name":"Burger, Lukas","last_name":"Burger"},{"first_name":"Cathrin","last_name":"Gräwe","full_name":"Gräwe, Cathrin"},{"orcid":"0000-0002-6080-839X","id":"6437c950-2a03-11ee-914d-d6476dd7b75c","first_name":"Alicia","full_name":"Michael, Alicia","last_name":"Michael"},{"first_name":"Luke","last_name":"Isbel","full_name":"Isbel, Luke"},{"full_name":"Hess, Daniel","last_name":"Hess","first_name":"Daniel"},{"first_name":"Leslie","last_name":"Hoerner","full_name":"Hoerner, Leslie"},{"first_name":"Vytautas","last_name":"Iesmantavicius","full_name":"Iesmantavicius, Vytautas"},{"last_name":"Durdu","full_name":"Durdu, Sevi","first_name":"Sevi"},{"first_name":"Marco","full_name":"Pregnolato, Marco","last_name":"Pregnolato"},{"first_name":"Arnaud R.","full_name":"Krebs, Arnaud R.","last_name":"Krebs"},{"full_name":"Smallwood, Sébastien A.","last_name":"Smallwood","first_name":"Sébastien A."},{"first_name":"Nicolas","last_name":"Thomä","full_name":"Thomä, Nicolas"},{"full_name":"Vermeulen, Michiel","last_name":"Vermeulen","first_name":"Michiel"},{"last_name":"Schübeler","full_name":"Schübeler, Dirk","first_name":"Dirk"}],"publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"year":"2021","_id":"15150"},{"related_material":{"link":[{"relation":"erratum","url":"https://doi.org/10.1038/s41586-021-03799-3"}]},"doi":"10.1038/s41586-021-03615-y","scopus_import":"1","status":"public","language":[{"iso":"eng"}],"volume":595,"external_id":{"arxiv":["2107.08458"]},"oa_version":"Preprint","date_published":"2021-06-30T00:00:00Z","type":"journal_article","intvolume":"       595","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2107.08458"}],"quality_controlled":"1","month":"06","date_updated":"2024-10-14T12:33:57Z","arxiv":1,"extern":"1","article_processing_charge":"No","day":"30","publication_status":"published","publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"year":"2021","_id":"15218","page":"39-42","abstract":[{"lang":"eng","text":"White dwarfs represent the last stage of evolution of stars with mass less than about eight times that of the Sun and, like other stars, are often found in binaries1,2. If the orbital period of the binary is short enough, energy losses from gravitational-wave radiation can shrink the orbit until the two white dwarfs come into contact and merge3. Depending on the component masses, the merger can lead to a supernova of type Ia or result in a massive white dwarf4. In the latter case, the white dwarf remnant is expected to be highly magnetized5,6 because of the strong magnetic dynamo that should arise during the merger, and be rapidly spinning from the conservation of the orbital angular momentum7. Here we report observations of a white dwarf, ZTF J190132.9+145808.7, that exhibits these properties, but to an extreme: a rotation period of 6.94 minutes, a magnetic field ranging between 600 megagauss and 900 megagauss over its surface, and a stellar radius of \r\n kilometres, only slightly larger than the radius of the Moon. Such a small radius implies that the star’s mass is close to the maximum white dwarf mass, or Chandrasekhar mass. ZTF J190132.9+145808.7 is likely to be cooling through the Urca processes (neutrino emission from electron capture on sodium) because of the high densities reached in its core."}],"publication":"Nature","author":[{"last_name":"Caiazzo","full_name":"Caiazzo, Ilaria","first_name":"Ilaria","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d","orcid":"0000-0002-4770-5388"},{"last_name":"Burdge","full_name":"Burdge, Kevin B.","first_name":"Kevin B."},{"last_name":"Fuller","full_name":"Fuller, James","first_name":"James"},{"first_name":"Jeremy","last_name":"Heyl","full_name":"Heyl, Jeremy"},{"full_name":"Kulkarni, S. R.","last_name":"Kulkarni","first_name":"S. R."},{"first_name":"Thomas A.","full_name":"Prince, Thomas A.","last_name":"Prince"},{"first_name":"Harvey B.","full_name":"Richer, Harvey B.","last_name":"Richer"},{"last_name":"Schwab","full_name":"Schwab, Josiah","first_name":"Josiah"},{"full_name":"Andreoni, Igor","last_name":"Andreoni","first_name":"Igor"},{"first_name":"Eric C.","full_name":"Bellm, Eric C.","last_name":"Bellm"},{"full_name":"Drake, Andrew","last_name":"Drake","first_name":"Andrew"},{"full_name":"Duev, Dmitry A.","last_name":"Duev","first_name":"Dmitry A."},{"last_name":"Graham","full_name":"Graham, Matthew J.","first_name":"Matthew J."},{"last_name":"Helou","full_name":"Helou, George","first_name":"George"},{"full_name":"Mahabal, Ashish A.","last_name":"Mahabal","first_name":"Ashish A."},{"last_name":"Masci","full_name":"Masci, Frank J.","first_name":"Frank J."},{"last_name":"Smith","full_name":"Smith, Roger","first_name":"Roger"},{"first_name":"Maayane T.","last_name":"Soumagnac","full_name":"Soumagnac, Maayane T."}],"title":"A highly magnetized and rapidly rotating white dwarf as small as the Moon","article_type":"original","issue":"7865","citation":{"chicago":"Caiazzo, Ilaria, Kevin B. Burdge, James Fuller, Jeremy Heyl, S. R. Kulkarni, Thomas A. Prince, Harvey B. Richer, et al. “A Highly Magnetized and Rapidly Rotating White Dwarf as Small as the Moon.” <i>Nature</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41586-021-03615-y\">https://doi.org/10.1038/s41586-021-03615-y</a>.","short":"I. Caiazzo, K.B. Burdge, J. Fuller, J. Heyl, S.R. Kulkarni, T.A. Prince, H.B. Richer, J. Schwab, I. Andreoni, E.C. Bellm, A. Drake, D.A. Duev, M.J. Graham, G. Helou, A.A. Mahabal, F.J. Masci, R. Smith, M.T. Soumagnac, Nature 595 (2021) 39–42.","ieee":"I. Caiazzo <i>et al.</i>, “A highly magnetized and rapidly rotating white dwarf as small as the Moon,” <i>Nature</i>, vol. 595, no. 7865. Springer Nature, pp. 39–42, 2021.","apa":"Caiazzo, I., Burdge, K. B., Fuller, J., Heyl, J., Kulkarni, S. R., Prince, T. A., … Soumagnac, M. T. (2021). A highly magnetized and rapidly rotating white dwarf as small as the Moon. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-021-03615-y\">https://doi.org/10.1038/s41586-021-03615-y</a>","ama":"Caiazzo I, Burdge KB, Fuller J, et al. A highly magnetized and rapidly rotating white dwarf as small as the Moon. <i>Nature</i>. 2021;595(7865):39-42. doi:<a href=\"https://doi.org/10.1038/s41586-021-03615-y\">10.1038/s41586-021-03615-y</a>","mla":"Caiazzo, Ilaria, et al. “A Highly Magnetized and Rapidly Rotating White Dwarf as Small as the Moon.” <i>Nature</i>, vol. 595, no. 7865, Springer Nature, 2021, pp. 39–42, doi:<a href=\"https://doi.org/10.1038/s41586-021-03615-y\">10.1038/s41586-021-03615-y</a>.","ista":"Caiazzo I, Burdge KB, Fuller J, Heyl J, Kulkarni SR, Prince TA, Richer HB, Schwab J, Andreoni I, Bellm EC, Drake A, Duev DA, Graham MJ, Helou G, Mahabal AA, Masci FJ, Smith R, Soumagnac MT. 2021. A highly magnetized and rapidly rotating white dwarf as small as the Moon. Nature. 595(7865), 39–42."},"oa":1,"fulldoi":"https://doi.org/10.1038/s41586-021-03615-y","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2024-03-26T10:33:03Z","publisher":"Springer Nature"},{"acknowledgement":"The authors acknowledge discussions with A. Macdonald, L. Fu, F. Wang and M. Zaletel. AFY acknowledges support of the National Science Foundation under DMR1654186, and the Gordon and Betty Moore Foundation under award GBMF9471. The authors acknowledge the use of the research facilities within the California NanoSystems Institute, supported by the University of California, Santa Barbara and the University of California, Office of the President.\r\nK.W. and T.T. acknowledge support from the Elemental Strategy Initiative conducted by the MEXT, Japan, Grant Number JPMXP0112101001 and JSPS KAKENHI, Grant Number JP20H00354. EB and TH were supported by the European Research Council (ERC) under grant HQMAT (Grant Agreement No. 817799). A.G. acknowledges support by the European Unions Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant Agreement\r\nNo. 754411.\r\n","fulldoi":"https://doi.org/10.1038/s41586-021-03938-w","isi":1,"publisher":"Springer Nature","date_created":"2021-09-19T22:01:25Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_type":"original","oa":1,"citation":{"ista":"Zhou H, Xie T, Ghazaryan A, Holder T, Ehrets JR, Spanton EM, Taniguchi T, Watanabe K, Berg E, Serbyn M, Young AF. 2021. Half and quarter metals in rhombohedral trilayer graphene. Nature.","ama":"Zhou H, Xie T, Ghazaryan A, et al. Half and quarter metals in rhombohedral trilayer graphene. <i>Nature</i>. 2021. doi:<a href=\"https://doi.org/10.1038/s41586-021-03938-w\">10.1038/s41586-021-03938-w</a>","mla":"Zhou, Haoxin, et al. “Half and Quarter Metals in Rhombohedral Trilayer Graphene.” <i>Nature</i>, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41586-021-03938-w\">10.1038/s41586-021-03938-w</a>.","apa":"Zhou, H., Xie, T., Ghazaryan, A., Holder, T., Ehrets, J. R., Spanton, E. M., … Young, A. F. (2021). Half and quarter metals in rhombohedral trilayer graphene. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-021-03938-w\">https://doi.org/10.1038/s41586-021-03938-w</a>","ieee":"H. Zhou <i>et al.</i>, “Half and quarter metals in rhombohedral trilayer graphene,” <i>Nature</i>. Springer Nature, 2021.","chicago":"Zhou, Haoxin, Tian Xie, Areg Ghazaryan, Tobias Holder, James R. Ehrets, Eric M. Spanton, Takashi Taniguchi, et al. “Half and Quarter Metals in Rhombohedral Trilayer Graphene.” <i>Nature</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41586-021-03938-w\">https://doi.org/10.1038/s41586-021-03938-w</a>.","short":"H. Zhou, T. Xie, A. Ghazaryan, T. Holder, J.R. Ehrets, E.M. Spanton, T. Taniguchi, K. Watanabe, E. Berg, M. Serbyn, A.F. Young, Nature (2021)."},"year":"2021","_id":"10025","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"title":"Half and quarter metals in rhombohedral trilayer graphene","publication":"Nature","author":[{"first_name":"Haoxin","last_name":"Zhou","full_name":"Zhou, Haoxin"},{"full_name":"Xie, Tian","last_name":"Xie","first_name":"Tian"},{"full_name":"Ghazaryan, Areg","last_name":"Ghazaryan","id":"4AF46FD6-F248-11E8-B48F-1D18A9856A87","first_name":"Areg","orcid":"0000-0001-9666-3543"},{"last_name":"Holder","full_name":"Holder, Tobias","first_name":"Tobias"},{"last_name":"Ehrets","full_name":"Ehrets, James R.","first_name":"James R."},{"full_name":"Spanton, Eric M.","last_name":"Spanton","first_name":"Eric M."},{"full_name":"Taniguchi, Takashi","last_name":"Taniguchi","first_name":"Takashi"},{"first_name":"Kenji","last_name":"Watanabe","full_name":"Watanabe, Kenji"},{"first_name":"Erez","last_name":"Berg","full_name":"Berg, Erez"},{"orcid":"0000-0002-2399-5827","id":"47809E7E-F248-11E8-B48F-1D18A9856A87","first_name":"Maksym","last_name":"Serbyn","full_name":"Serbyn, Maksym"},{"first_name":"Andrea F.","last_name":"Young","full_name":"Young, Andrea F."}],"abstract":[{"lang":"eng","text":"Ferromagnetism is most common in transition metal compounds but may also arise in low-density two-dimensional electron systems, with signatures observed in silicon, III-V semiconductor systems, and graphene moiré heterostructures. Here we show that gate-tuned van Hove singularities in rhombohedral trilayer graphene drive the spontaneous ferromagnetic polarization of the electron system into one or more spin- and valley flavors. Using capacitance measurements on graphite-gated van der Waals heterostructures, we find a cascade of density- and electronic displacement field tuned phase transitions marked by negative electronic compressibility. The transitions define the boundaries between phases where quantum oscillations have either four-fold, two-fold, or one-fold degeneracy, associated with a spin and valley degenerate normal metal, spin-polarized `half-metal', and spin and valley polarized `quarter metal', respectively. For electron doping, the salient features are well captured by a phenomenological Stoner model with a valley-anisotropic Hund's coupling, likely arising from interactions at the lattice scale. For hole filling, we observe a richer phase diagram featuring a delicate interplay of broken symmetries and transitions in the Fermi surface topology. Finally, by rotational alignment of a hexagonal boron nitride substrate to induce a moiré superlattice, we find that the superlattice perturbs the preexisting isospin order only weakly, leaving the basic phase diagram intact while catalyzing the formation of topologically nontrivial gapped states whenever itinerant half- or quarter metal states occur at half- or quarter superlattice band filling. Our results show that rhombohedral trilayer graphene is an ideal platform for well-controlled tests of many-body theory and reveal magnetism in moiré materials to be fundamentally itinerant in nature."}],"date_updated":"2025-04-14T07:43:46Z","arxiv":1,"publication_status":"published","day":"01","article_processing_charge":"No","ec_funded":1,"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2104.00653"}],"quality_controlled":"1","month":"09","external_id":{"isi":["000706977400002"],"arxiv":["2104.00653"]},"keyword":["condensed matter - mesoscale and nanoscale physics","condensed matter - strongly correlated electrons","multidisciplinary"],"language":[{"iso":"eng"}],"date_published":"2021-09-01T00:00:00Z","type":"journal_article","oa_version":"Preprint","project":[{"call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"department":[{"_id":"MaSe"},{"_id":"MiLe"}],"status":"public","doi":"10.1038/s41586-021-03938-w","related_material":{"link":[{"relation":"erratum","url":"https://doi.org/10.1038/s41586-021-04181-z"}]},"scopus_import":"1"},{"month":"10","quality_controlled":"1","oa_version":"None","acknowledged_ssus":[{"_id":"PreCl"},{"_id":"EM-Fac"},{"_id":"ScienComp"}],"intvolume":"       598","type":"journal_article","date_published":"2021-10-14T00:00:00Z","volume":598,"external_id":{"isi":["000704581600001"],"pmid":["34616041"]},"language":[{"iso":"eng"}],"status":"public","project":[{"_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020"}],"department":[{"_id":"LeSa"}],"corr_author":"1","scopus_import":"1","pmid":1,"doi":"10.1038/s41586-021-03927-z","related_material":{"link":[{"relation":"press_release","url":"https://ist.ac.at/en/news/boosting-the-cells-power-house/","description":"News on IST Webpage"}]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","isi":1,"publisher":"Springer Nature","date_created":"2021-10-17T22:01:17Z","acknowledgement":"We thank the pre-clinical facility of the IST Austria and A. Venturino for assistance with the animals; and V.-V. Hodirnau for assistance during the Titan Krios data collection, performed at the IST Austria. The data processing was performed at the IST high-performance computing cluster. This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement no. 754411.","fulldoi":"https://doi.org/10.1038/s41586-021-03927-z","citation":{"chicago":"Vercellino, Irene, and Leonid A Sazanov. “Structure and Assembly of the Mammalian Mitochondrial Supercomplex CIII<sub>2</sub>CIV.” <i>Nature</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41586-021-03927-z\">https://doi.org/10.1038/s41586-021-03927-z</a>.","short":"I. Vercellino, L.A. Sazanov, Nature 598 (2021) 364–367.","ieee":"I. Vercellino and L. A. Sazanov, “Structure and assembly of the mammalian mitochondrial supercomplex CIII<sub>2</sub>CIV,” <i>Nature</i>, vol. 598, no. 7880. Springer Nature, pp. 364–367, 2021.","mla":"Vercellino, Irene, and Leonid A. Sazanov. “Structure and Assembly of the Mammalian Mitochondrial Supercomplex CIII<sub>2</sub>CIV.” <i>Nature</i>, vol. 598, no. 7880, Springer Nature, 2021, pp. 364–67, doi:<a href=\"https://doi.org/10.1038/s41586-021-03927-z\">10.1038/s41586-021-03927-z</a>.","ama":"Vercellino I, Sazanov LA. Structure and assembly of the mammalian mitochondrial supercomplex CIII<sub>2</sub>CIV. <i>Nature</i>. 2021;598(7880):364-367. doi:<a href=\"https://doi.org/10.1038/s41586-021-03927-z\">10.1038/s41586-021-03927-z</a>","apa":"Vercellino, I., &#38; Sazanov, L. A. (2021). Structure and assembly of the mammalian mitochondrial supercomplex CIII<sub>2</sub>CIV. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-021-03927-z\">https://doi.org/10.1038/s41586-021-03927-z</a>","ista":"Vercellino I, Sazanov LA. 2021. Structure and assembly of the mammalian mitochondrial supercomplex CIII<sub>2</sub>CIV. Nature. 598(7880), 364–367."},"issue":"7880","article_type":"original","abstract":[{"text":"The enzymes of the mitochondrial electron transport chain are key players of cell metabolism. Despite being active when isolated, in vivo they associate into supercomplexes1, whose precise role is debated. Supercomplexes CIII2CIV1-2 (refs. 2,3), CICIII2 (ref. 4) and CICIII2CIV (respirasome)5,6,7,8,9,10 exist in mammals, but in contrast to CICIII2 and the respirasome, to date the only known eukaryotic structures of CIII2CIV1-2 come from Saccharomyces cerevisiae11,12 and plants13, which have different organization. Here we present the first, to our knowledge, structures of mammalian (mouse and ovine) CIII2CIV and its assembly intermediates, in different conformations. We describe the assembly of CIII2CIV from the CIII2 precursor to the final CIII2CIV conformation, driven by the insertion of the N terminus of the assembly factor SCAF1 (ref. 14) deep into CIII2, while its C terminus is integrated into CIV. Our structures (which include CICIII2 and the respirasome) also confirm that SCAF1 is exclusively required for the assembly of CIII2CIV and has no role in the assembly of the respirasome. We show that CIII2 is asymmetric due to the presence of only one copy of subunit 9, which straddles both monomers and prevents the attachment of a second copy of SCAF1 to CIII2, explaining the presence of one copy of CIV in CIII2CIV in mammals. Finally, we show that CIII2 and CIV gain catalytic advantage when assembled into the supercomplex and propose a role for CIII2CIV in fine tuning the efficiency of electron transfer in the electron transport chain.","lang":"eng"}],"page":"364-367","author":[{"last_name":"Vercellino","full_name":"Vercellino, Irene","orcid":"0000-0001-5618-3449","first_name":"Irene","id":"3ED6AF16-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0977-7989","full_name":"Sazanov, Leonid A","last_name":"Sazanov"}],"title":"Structure and assembly of the mammalian mitochondrial supercomplex CIII<sub>2</sub>CIV","publication":"Nature","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"_id":"10146","year":"2021","ec_funded":1,"publication_status":"published","article_processing_charge":"No","day":"14","date_updated":"2025-04-14T07:43:46Z"},{"publication_status":"published","article_processing_charge":"No","day":"11","ec_funded":1,"date_updated":"2025-07-10T11:49:46Z","author":[{"orcid":"0000-0002-5607-272X","first_name":"Lanxin","id":"367EF8FA-F248-11E8-B48F-1D18A9856A87","full_name":"Li, Lanxin","last_name":"Li"},{"orcid":"0000-0001-7241-2328","id":"362BF7FE-F248-11E8-B48F-1D18A9856A87","first_name":"Inge","full_name":"Verstraeten, Inge","last_name":"Verstraeten"},{"full_name":"Roosjen, Mark","last_name":"Roosjen","first_name":"Mark"},{"first_name":"Koji","last_name":"Takahashi","full_name":"Takahashi, Koji"},{"last_name":"Rodriguez Solovey","full_name":"Rodriguez Solovey, Lesia","first_name":"Lesia","id":"3922B506-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7244-7237"},{"full_name":"Merrin, Jack","last_name":"Merrin","orcid":"0000-0001-5145-4609","first_name":"Jack","id":"4515C308-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Chen","full_name":"Chen, Jian","first_name":"Jian"},{"first_name":"Lana","last_name":"Shabala","full_name":"Shabala, Lana"},{"full_name":"Smet, Wouter","last_name":"Smet","first_name":"Wouter"},{"first_name":"Hong","full_name":"Ren, Hong","last_name":"Ren"},{"first_name":"Steffen","full_name":"Vanneste, Steffen","last_name":"Vanneste"},{"first_name":"Sergey","full_name":"Shabala, Sergey","last_name":"Shabala"},{"first_name":"Bert","last_name":"De Rybel","full_name":"De Rybel, Bert"},{"first_name":"Dolf","last_name":"Weijers","full_name":"Weijers, Dolf"},{"first_name":"Toshinori","full_name":"Kinoshita, Toshinori","last_name":"Kinoshita"},{"last_name":"Gray","full_name":"Gray, William M.","first_name":"William M."},{"full_name":"Friml, Jiří","last_name":"Friml","first_name":"Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596"}],"title":"Cell surface and intracellular auxin signalling for H<sup>+</sup> fluxes in root growth","publication":"Nature","abstract":[{"lang":"eng","text":"Growth regulation tailors development in plants to their environment. A prominent example of this is the response to gravity, in which shoots bend up and roots bend down1. This paradox is based on opposite effects of the phytohormone auxin, which promotes cell expansion in shoots while inhibiting it in roots via a yet unknown cellular mechanism2. Here, by combining microfluidics, live imaging, genetic engineering and phosphoproteomics in Arabidopsis thaliana, we advance understanding of how auxin inhibits root growth. We show that auxin activates two distinct, antagonistically acting signalling pathways that converge on rapid regulation of apoplastic pH, a causative determinant of growth. Cell surface-based TRANSMEMBRANE KINASE1 (TMK1) interacts with and mediates phosphorylation and activation of plasma membrane H+-ATPases for apoplast acidification, while intracellular canonical auxin signalling promotes net cellular H+ influx, causing apoplast alkalinization. Simultaneous activation of these two counteracting mechanisms poises roots for rapid, fine-tuned growth modulation in navigating complex soil environments."}],"page":"273-277","_id":"10223","year":"2021","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"oa":1,"citation":{"ieee":"L. Li <i>et al.</i>, “Cell surface and intracellular auxin signalling for H<sup>+</sup> fluxes in root growth,” <i>Nature</i>, vol. 599, no. 7884. Springer Nature, pp. 273–277, 2021.","apa":"Li, L., Verstraeten, I., Roosjen, M., Takahashi, K., Rodriguez Solovey, L., Merrin, J., … Friml, J. (2021). Cell surface and intracellular auxin signalling for H<sup>+</sup> fluxes in root growth. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-021-04037-6\">https://doi.org/10.1038/s41586-021-04037-6</a>","ama":"Li L, Verstraeten I, Roosjen M, et al. Cell surface and intracellular auxin signalling for H<sup>+</sup> fluxes in root growth. <i>Nature</i>. 2021;599(7884):273-277. doi:<a href=\"https://doi.org/10.1038/s41586-021-04037-6\">10.1038/s41586-021-04037-6</a>","mla":"Li, Lanxin, et al. “Cell Surface and Intracellular Auxin Signalling for H<sup>+</sup> Fluxes in Root Growth.” <i>Nature</i>, vol. 599, no. 7884, Springer Nature, 2021, pp. 273–77, doi:<a href=\"https://doi.org/10.1038/s41586-021-04037-6\">10.1038/s41586-021-04037-6</a>.","ista":"Li L, Verstraeten I, Roosjen M, Takahashi K, Rodriguez Solovey L, Merrin J, Chen J, Shabala L, Smet W, Ren H, Vanneste S, Shabala S, De Rybel B, Weijers D, Kinoshita T, Gray WM, Friml J. 2021. Cell surface and intracellular auxin signalling for H<sup>+</sup> fluxes in root growth. Nature. 599(7884), 273–277.","chicago":"Li, Lanxin, Inge Verstraeten, Mark Roosjen, Koji Takahashi, Lesia Rodriguez Solovey, Jack Merrin, Jian Chen, et al. “Cell Surface and Intracellular Auxin Signalling for H<sup>+</sup> Fluxes in Root Growth.” <i>Nature</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41586-021-04037-6\">https://doi.org/10.1038/s41586-021-04037-6</a>.","short":"L. Li, I. Verstraeten, M. Roosjen, K. Takahashi, L. Rodriguez Solovey, J. Merrin, J. Chen, L. Shabala, W. Smet, H. Ren, S. Vanneste, S. Shabala, B. De Rybel, D. Weijers, T. Kinoshita, W.M. Gray, J. Friml, Nature 599 (2021) 273–277."},"issue":"7884","article_type":"original","isi":1,"publisher":"Springer Nature","date_created":"2021-11-07T23:01:25Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"We thank N. Gnyliukh and L. Hörmayer for technical assistance and N. Paris for sharing PM-Cyto seeds. We gratefully acknowledge the Life Science, Machine Shop and Bioimaging Facilities of IST Austria. This project has received funding from the European Research Council Advanced Grant (ETAP-742985) and the Austrian Science Fund (FWF) under I 3630-B25 to J.F., the National Institutes of Health (GM067203) to W.M.G., the Netherlands Organization for Scientific Research (NWO; VIDI-864.13.001), Research Foundation-Flanders (FWO; Odysseus II G0D0515N) and a European Research Council Starting Grant (TORPEDO-714055) to W.S. and B.D.R., the VICI grant (865.14.001) from the Netherlands Organization for Scientific Research to M.R. and D.W., the Australian Research Council and China National Distinguished Expert Project (WQ20174400441) to S.S., the MEXT/JSPS KAKENHI to K.T. (20K06685) and T.K. (20H05687 and 20H05910), the European Union’s Horizon 2020 research and innovation programme under Marie Skłodowska-Curie grant agreement no. 665385 and the DOC Fellowship of the Austrian Academy of Sciences to L.L., and the China Scholarship Council to J.C.","fulldoi":"https://doi.org/10.1038/s41586-021-04037-6","pmid":1,"scopus_import":"1","doi":"10.1038/s41586-021-04037-6","related_material":{"link":[{"url":"https://ist.ac.at/en/news/stop-and-grow/","relation":"press_release","description":"News on IST Webpage"}],"record":[{"status":"public","relation":"earlier_version","id":"10095"}]},"project":[{"grant_number":"742985","_id":"261099A6-B435-11E9-9278-68D0E5697425","name":"Tracing Evolution of Auxin Transport and Polarity in Plants","call_identifier":"H2020"},{"call_identifier":"FWF","_id":"26538374-B435-11E9-9278-68D0E5697425","name":"Molecular mechanisms of endocytic cargo recognition in plants","grant_number":"I03630"},{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385","name":"International IST Doctoral Program","call_identifier":"H2020"},{"grant_number":"25351","_id":"26B4D67E-B435-11E9-9278-68D0E5697425","name":"A Case Study of Plant Growth Regulation: Molecular Mechanism of Auxin-mediated Rapid Growth Inhibition in Arabidopsis Root"}],"department":[{"_id":"JiFr"},{"_id":"NanoFab"}],"status":"public","corr_author":"1","intvolume":"       599","acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"M-Shop"},{"_id":"Bio"}],"type":"journal_article","date_published":"2021-11-11T00:00:00Z","oa_version":"Preprint","volume":599,"external_id":{"pmid":["34707283"],"isi":["000713338100006"]},"language":[{"iso":"eng"}],"keyword":["Multidisciplinary"],"month":"11","quality_controlled":"1","main_file_link":[{"url":"https://www.doi.org/10.21203/rs.3.rs-266395/v3","open_access":"1"}]},{"language":[{"iso":"eng"}],"external_id":{"isi":["000591047800005"],"pmid":["33208951"]},"volume":589,"oa_version":"None","type":"journal_article","date_published":"2021-01-07T00:00:00Z","intvolume":"       589","quality_controlled":"1","month":"01","related_material":{"link":[{"url":"https://doi.org/10.1038/s41586-020-03068-9","relation":"erratum"}]},"doi":"10.1038/s41586-020-2914-4","scopus_import":"1","pmid":1,"status":"public","department":[{"_id":"JoCs"}],"article_type":"original","issue":"7840","citation":{"ista":"Ramirez Villegas JF, Besserve M, Murayama Y, Evrard HC, Oeltermann A, Logothetis NK. 2021. Coupling of hippocampal theta and ripples with pontogeniculooccipital waves. Nature. 589(7840), 96–102.","mla":"Ramirez Villegas, Juan F., et al. “Coupling of Hippocampal Theta and Ripples with Pontogeniculooccipital Waves.” <i>Nature</i>, vol. 589, no. 7840, Springer Nature, 2021, pp. 96–102, doi:<a href=\"https://doi.org/10.1038/s41586-020-2914-4\">10.1038/s41586-020-2914-4</a>.","ama":"Ramirez Villegas JF, Besserve M, Murayama Y, Evrard HC, Oeltermann A, Logothetis NK. Coupling of hippocampal theta and ripples with pontogeniculooccipital waves. <i>Nature</i>. 2021;589(7840):96-102. doi:<a href=\"https://doi.org/10.1038/s41586-020-2914-4\">10.1038/s41586-020-2914-4</a>","apa":"Ramirez Villegas, J. F., Besserve, M., Murayama, Y., Evrard, H. C., Oeltermann, A., &#38; Logothetis, N. K. (2021). Coupling of hippocampal theta and ripples with pontogeniculooccipital waves. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-020-2914-4\">https://doi.org/10.1038/s41586-020-2914-4</a>","ieee":"J. F. Ramirez Villegas, M. Besserve, Y. Murayama, H. C. Evrard, A. Oeltermann, and N. K. Logothetis, “Coupling of hippocampal theta and ripples with pontogeniculooccipital waves,” <i>Nature</i>, vol. 589, no. 7840. Springer Nature, pp. 96–102, 2021.","chicago":"Ramirez Villegas, Juan F, Michel Besserve, Yusuke Murayama, Henry C. Evrard, Axel Oeltermann, and Nikos K. Logothetis. “Coupling of Hippocampal Theta and Ripples with Pontogeniculooccipital Waves.” <i>Nature</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41586-020-2914-4\">https://doi.org/10.1038/s41586-020-2914-4</a>.","short":"J.F. Ramirez Villegas, M. Besserve, Y. Murayama, H.C. Evrard, A. Oeltermann, N.K. Logothetis, Nature 589 (2021) 96–102."},"fulldoi":"https://doi.org/10.1038/s41586-020-2914-4","acknowledgement":"We thank O. Eschenko and M. Constantinou for providing feedback on earlier versions of this work, and J. Werner and M. Schnabel for technical support during the development of this study. This research was supported by the Max Planck Society.","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2020-11-29T23:01:19Z","isi":1,"publisher":"Springer Nature","date_updated":"2025-07-10T12:01:26Z","day":"07","article_processing_charge":"No","publication_status":"published","publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"_id":"8818","year":"2021","page":"96-102","abstract":[{"lang":"eng","text":"The hippocampus has a major role in encoding and consolidating long-term memories, and undergoes plastic changes during sleep1. These changes require precise homeostatic control by subcortical neuromodulatory structures2. The underlying mechanisms of this phenomenon, however, remain unknown. Here, using multi-structure recordings in macaque monkeys, we show that the brainstem transiently modulates hippocampal network events through phasic pontine waves known as pontogeniculooccipital waves (PGO waves). Two physiologically distinct types of PGO wave appear to occur sequentially, selectively influencing high-frequency ripples and low-frequency theta events, respectively. The two types of PGO wave are associated with opposite hippocampal spike-field coupling, prompting periods of high neural synchrony of neural populations during periods of ripple and theta instances. The coupling between PGO waves and ripples, classically associated with distinct sleep stages, supports the notion that a global coordination mechanism of hippocampal sleep dynamics by cholinergic pontine transients may promote systems and synaptic memory consolidation as well as synaptic homeostasis."}],"author":[{"full_name":"Ramirez Villegas, Juan F","last_name":"Ramirez Villegas","id":"44B06F76-F248-11E8-B48F-1D18A9856A87","first_name":"Juan F"},{"last_name":"Besserve","full_name":"Besserve, Michel","first_name":"Michel"},{"first_name":"Yusuke","last_name":"Murayama","full_name":"Murayama, Yusuke"},{"last_name":"Evrard","full_name":"Evrard, Henry C.","first_name":"Henry C."},{"first_name":"Axel","full_name":"Oeltermann, Axel","last_name":"Oeltermann"},{"first_name":"Nikos K.","last_name":"Logothetis","full_name":"Logothetis, Nikos K."}],"publication":"Nature","title":"Coupling of hippocampal theta and ripples with pontogeniculooccipital waves"},{"volume":594,"external_id":{"pmid":["34079129"],"isi":["000657238100003"]},"language":[{"iso":"eng"}],"intvolume":"       594","date_published":"2021-06-02T00:00:00Z","type":"journal_article","oa_version":"Published Version","quality_controlled":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41586-021-03613-0"}],"ddc":["570"],"month":"06","doi":"10.1038/s41586-021-03613-0","pmid":1,"scopus_import":"1","department":[{"_id":"PeJo"}],"status":"public","article_type":"original","oa":1,"citation":{"ama":"Zhang D, Watson J, Matthews PM, Cais O, Greger IH. Gating and modulation of a hetero-octameric AMPA glutamate receptor. <i>Nature</i>. 2021;594:454-458. doi:<a href=\"https://doi.org/10.1038/s41586-021-03613-0\">10.1038/s41586-021-03613-0</a>","apa":"Zhang, D., Watson, J., Matthews, P. M., Cais, O., &#38; Greger, I. H. (2021). Gating and modulation of a hetero-octameric AMPA glutamate receptor. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-021-03613-0\">https://doi.org/10.1038/s41586-021-03613-0</a>","mla":"Zhang, Danyang, et al. “Gating and Modulation of a Hetero-Octameric AMPA Glutamate Receptor.” <i>Nature</i>, vol. 594, Springer Nature, 2021, pp. 454–58, doi:<a href=\"https://doi.org/10.1038/s41586-021-03613-0\">10.1038/s41586-021-03613-0</a>.","ista":"Zhang D, Watson J, Matthews PM, Cais O, Greger IH. 2021. Gating and modulation of a hetero-octameric AMPA glutamate receptor. Nature. 594, 454–458.","ieee":"D. Zhang, J. Watson, P. M. Matthews, O. Cais, and I. H. Greger, “Gating and modulation of a hetero-octameric AMPA glutamate receptor,” <i>Nature</i>, vol. 594. Springer Nature, pp. 454–458, 2021.","short":"D. Zhang, J. Watson, P.M. Matthews, O. Cais, I.H. Greger, Nature 594 (2021) 454–458.","chicago":"Zhang, Danyang, Jake Watson, Peter M. Matthews, Ondrej Cais, and Ingo H. Greger. “Gating and Modulation of a Hetero-Octameric AMPA Glutamate Receptor.” <i>Nature</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41586-021-03613-0\">https://doi.org/10.1038/s41586-021-03613-0</a>."},"acknowledgement":"We thank members of the Greger laboratory, B. Herguedas, J. Krieger and J.-N. Dohrke for comments on the manuscript; J. Krieger and J.-N. Dohrke for discussion, J. Krieger for help with the normal mode analysis, B. Köhegyi for help with cryo-EM imaging, V. Chang and K. Suzuki for helping to generate the CNIH2-1D4-HA stable cell line, M. Carvalho for assistance at early stages of this project, the LMB scientific computing and the cryo-EM facility for support, P. Emsley for help with model building, T. Nakane for helpful comments with RELION 3.1 and R. Warshamanage for helping with EMDA cryo-EM-map processing. We acknowledge the Diamond Light Source for access and support of the Cryo-EM facilities at the UK national electron bio10 imaging centre (eBIC), proposal EM17434, funded by the Wellcome Trust, MRC and BBSRC. This work was supported by grants from the Medical Research Council, as part of United Kingdom Research and Innovation (also known as UK Research and Innovation) (MC_U105174197) and BBSRC (BB/N002113/1) to I.H.G.","fulldoi":"https://doi.org/10.1038/s41586-021-03613-0","isi":1,"publisher":"Springer Nature","date_created":"2021-06-13T22:01:33Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-06-18T19:54:04Z","publication_status":"published","day":"02","article_processing_charge":"No","year":"2021","_id":"9549","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"title":"Gating and modulation of a hetero-octameric AMPA glutamate receptor","author":[{"first_name":"Danyang","full_name":"Zhang, Danyang","last_name":"Zhang"},{"full_name":"Watson, Jake","last_name":"Watson","orcid":"0000-0002-8698-3823","id":"63836096-4690-11EA-BD4E-32803DDC885E","first_name":"Jake"},{"full_name":"Matthews, Peter M.","last_name":"Matthews","first_name":"Peter M."},{"last_name":"Cais","full_name":"Cais, Ondrej","first_name":"Ondrej"},{"first_name":"Ingo H.","last_name":"Greger","full_name":"Greger, Ingo H."}],"publication":"Nature","abstract":[{"text":"AMPA receptors (AMPARs) mediate the majority of excitatory transmission in the brain and enable the synaptic plasticity that underlies learning1. A diverse array of AMPAR signalling complexes are established by receptor auxiliary subunits, which associate with the AMPAR in various combinations to modulate trafficking, gating and synaptic strength2. However, their mechanisms of action are poorly understood. Here we determine cryo-electron microscopy structures of the heteromeric GluA1–GluA2 receptor assembled with both TARP-γ8 and CNIH2, the predominant AMPAR complex in the forebrain, in both resting and active states. Two TARP-γ8 and two CNIH2 subunits insert at distinct sites beneath the ligand-binding domains of the receptor, with site-specific lipids shaping each interaction and affecting the gating regulation of the AMPARs. Activation of the receptor leads to asymmetry between GluA1 and GluA2 along the ion conduction path and an outward expansion of the channel triggers counter-rotations of both auxiliary subunit pairs, promoting the active-state conformation. In addition, both TARP-γ8 and CNIH2 pivot towards the pore exit upon activation, extending their reach for cytoplasmic receptor elements. CNIH2 achieves this through its uniquely extended M2 helix, which has transformed this endoplasmic reticulum-export factor into a powerful AMPAR modulator that is capable of providing hippocampal pyramidal neurons with their integrative synaptic properties. ","lang":"eng"}],"page":"454-458"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Springer Nature","date_created":"2023-02-20T08:12:53Z","fulldoi":"https://doi.org/10.1038/s41586-019-1822-y","citation":{"short":"W.W. Immerzeel, A.F. Lutz, M. Andrade, A. Bahl, H. Biemans, T. Bolch, S. Hyde, S. Brumby, B.J. Davies, A.C. Elmore, A. Emmer, M. Feng, A. Fernández, U. Haritashya, J.S. Kargel, M. Koppes, P.D.A. Kraaijenbrink, A.V. Kulkarni, P.A. Mayewski, S. Nepal, P. Pacheco, T.H. Painter, F. Pellicciotti, H. Rajaram, S. Rupper, A. Sinisalo, A.B. Shrestha, D. Viviroli, Y. Wada, C. Xiao, T. Yao, J.E.M. Baillie, Nature 577 (2020) 364–369.","chicago":"Immerzeel, W. W., A. F. Lutz, M. Andrade, A. Bahl, H. Biemans, T. Bolch, S. Hyde, et al. “Importance and Vulnerability of the World’s Water Towers.” <i>Nature</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41586-019-1822-y\">https://doi.org/10.1038/s41586-019-1822-y</a>.","apa":"Immerzeel, W. W., Lutz, A. F., Andrade, M., Bahl, A., Biemans, H., Bolch, T., … Baillie, J. E. M. (2020). Importance and vulnerability of the world’s water towers. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-019-1822-y\">https://doi.org/10.1038/s41586-019-1822-y</a>","mla":"Immerzeel, W. W., et al. “Importance and Vulnerability of the World’s Water Towers.” <i>Nature</i>, vol. 577, no. 7790, Springer Nature, 2020, pp. 364–69, doi:<a href=\"https://doi.org/10.1038/s41586-019-1822-y\">10.1038/s41586-019-1822-y</a>.","ama":"Immerzeel WW, Lutz AF, Andrade M, et al. Importance and vulnerability of the world’s water towers. <i>Nature</i>. 2020;577(7790):364-369. doi:<a href=\"https://doi.org/10.1038/s41586-019-1822-y\">10.1038/s41586-019-1822-y</a>","ista":"Immerzeel WW, Lutz AF, Andrade M, Bahl A, Biemans H, Bolch T, Hyde S, Brumby S, Davies BJ, Elmore AC, Emmer A, Feng M, Fernández A, Haritashya U, Kargel JS, Koppes M, Kraaijenbrink PDA, Kulkarni AV, Mayewski PA, Nepal S, Pacheco P, Painter TH, Pellicciotti F, Rajaram H, Rupper S, Sinisalo A, Shrestha AB, Viviroli D, Wada Y, Xiao C, Yao T, Baillie JEM. 2020. Importance and vulnerability of the world’s water towers. Nature. 577(7790), 364–369.","ieee":"W. W. Immerzeel <i>et al.</i>, “Importance and vulnerability of the world’s water towers,” <i>Nature</i>, vol. 577, no. 7790. Springer Nature, pp. 364–369, 2020."},"issue":"7790","article_type":"original","abstract":[{"lang":"eng","text":"Mountains are the water towers of the world, supplying a substantial part of both natural and anthropogenic water demands1,2. They are highly sensitive and prone to climate change3,4, yet their importance and vulnerability have not been quantified at the global scale. Here we present a global water tower index (WTI), which ranks all water towers in terms of their water-supplying role and the downstream dependence of ecosystems and society. For each water tower, we assess its vulnerability related to water stress, governance, hydropolitical tension and future climatic and socio-economic changes. We conclude that the most important (highest WTI) water towers are also among the most vulnerable, and that climatic and socio-economic changes will affect them profoundly. This could negatively impact 1.9 billion people living in (0.3 billion) or directly downstream of (1.6 billion) mountainous areas. Immediate action is required to safeguard the future of the world’s most important and vulnerable water towers."}],"page":"364-369","publication":"Nature","title":"Importance and vulnerability of the world’s water towers","author":[{"first_name":"W. W.","last_name":"Immerzeel","full_name":"Immerzeel, W. W."},{"last_name":"Lutz","full_name":"Lutz, A. F.","first_name":"A. F."},{"last_name":"Andrade","full_name":"Andrade, M.","first_name":"M."},{"first_name":"A.","full_name":"Bahl, A.","last_name":"Bahl"},{"last_name":"Biemans","full_name":"Biemans, H.","first_name":"H."},{"last_name":"Bolch","full_name":"Bolch, T.","first_name":"T."},{"last_name":"Hyde","full_name":"Hyde, S.","first_name":"S."},{"full_name":"Brumby, S.","last_name":"Brumby","first_name":"S."},{"full_name":"Davies, B. J.","last_name":"Davies","first_name":"B. J."},{"full_name":"Elmore, A. C.","last_name":"Elmore","first_name":"A. C."},{"first_name":"A.","last_name":"Emmer","full_name":"Emmer, A."},{"first_name":"M.","full_name":"Feng, M.","last_name":"Feng"},{"last_name":"Fernández","full_name":"Fernández, A.","first_name":"A."},{"full_name":"Haritashya, U.","last_name":"Haritashya","first_name":"U."},{"first_name":"J. S.","last_name":"Kargel","full_name":"Kargel, J. S."},{"last_name":"Koppes","full_name":"Koppes, M.","first_name":"M."},{"first_name":"P. D. A.","last_name":"Kraaijenbrink","full_name":"Kraaijenbrink, P. D. A."},{"first_name":"A. V.","last_name":"Kulkarni","full_name":"Kulkarni, A. V."},{"first_name":"P. A.","last_name":"Mayewski","full_name":"Mayewski, P. A."},{"full_name":"Nepal, S.","last_name":"Nepal","first_name":"S."},{"first_name":"P.","full_name":"Pacheco, P.","last_name":"Pacheco"},{"last_name":"Painter","full_name":"Painter, T. H.","first_name":"T. H."},{"first_name":"Francesca","id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70","full_name":"Pellicciotti, Francesca","last_name":"Pellicciotti"},{"first_name":"H.","full_name":"Rajaram, H.","last_name":"Rajaram"},{"first_name":"S.","last_name":"Rupper","full_name":"Rupper, S."},{"first_name":"A.","last_name":"Sinisalo","full_name":"Sinisalo, A."},{"first_name":"A. B.","last_name":"Shrestha","full_name":"Shrestha, A. B."},{"last_name":"Viviroli","full_name":"Viviroli, D.","first_name":"D."},{"last_name":"Wada","full_name":"Wada, Y.","first_name":"Y."},{"last_name":"Xiao","full_name":"Xiao, C.","first_name":"C."},{"first_name":"T.","full_name":"Yao, T.","last_name":"Yao"},{"first_name":"J. E. M.","full_name":"Baillie, J. E. M.","last_name":"Baillie"}],"publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"_id":"12599","year":"2020","extern":"1","publication_status":"published","day":"16","article_processing_charge":"No","date_updated":"2023-02-28T12:17:38Z","month":"01","quality_controlled":"1","oa_version":"None","intvolume":"       577","type":"journal_article","date_published":"2020-01-16T00:00:00Z","volume":577,"language":[{"iso":"eng"}],"status":"public","scopus_import":"1","doi":"10.1038/s41586-019-1822-y"},{"intvolume":"       588","date_published":"2020-11-23T00:00:00Z","type":"journal_article","oa_version":"Preprint","volume":588,"external_id":{"arxiv":["2004.11353"],"pmid":["33230333"]},"language":[{"iso":"eng"}],"keyword":["multidisciplinary"],"month":"11","quality_controlled":"1","main_file_link":[{"url":"https://arxiv.org/abs/2004.11353","open_access":"1"}],"pmid":1,"scopus_import":"1","doi":"10.1038/s41586-020-2963-8","status":"public","oa":1,"citation":{"chicago":"Polshyn, Hryhoriy, J. Zhu, M. A. Kumar, Y. Zhang, F. Yang, C. L. Tschirhart, M. Serlin, et al. “Electrical Switching of Magnetic Order in an Orbital Chern Insulator.” <i>Nature</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41586-020-2963-8\">https://doi.org/10.1038/s41586-020-2963-8</a>.","short":"H. Polshyn, J. Zhu, M.A. Kumar, Y. Zhang, F. Yang, C.L. Tschirhart, M. Serlin, K. Watanabe, T. Taniguchi, A.H. MacDonald, A.F. Young, Nature 588 (2020) 66–70.","ieee":"H. Polshyn <i>et al.</i>, “Electrical switching of magnetic order in an orbital Chern insulator,” <i>Nature</i>, vol. 588, no. 7836. Springer Nature, pp. 66–70, 2020.","ama":"Polshyn H, Zhu J, Kumar MA, et al. Electrical switching of magnetic order in an orbital Chern insulator. <i>Nature</i>. 2020;588(7836):66-70. doi:<a href=\"https://doi.org/10.1038/s41586-020-2963-8\">10.1038/s41586-020-2963-8</a>","mla":"Polshyn, Hryhoriy, et al. “Electrical Switching of Magnetic Order in an Orbital Chern Insulator.” <i>Nature</i>, vol. 588, no. 7836, Springer Nature, 2020, pp. 66–70, doi:<a href=\"https://doi.org/10.1038/s41586-020-2963-8\">10.1038/s41586-020-2963-8</a>.","apa":"Polshyn, H., Zhu, J., Kumar, M. A., Zhang, Y., Yang, F., Tschirhart, C. L., … Young, A. F. (2020). Electrical switching of magnetic order in an orbital Chern insulator. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-020-2963-8\">https://doi.org/10.1038/s41586-020-2963-8</a>","ista":"Polshyn H, Zhu J, Kumar MA, Zhang Y, Yang F, Tschirhart CL, Serlin M, Watanabe K, Taniguchi T, MacDonald AH, Young AF. 2020. Electrical switching of magnetic order in an orbital Chern insulator. Nature. 588(7836), 66–70."},"issue":"7836","article_type":"original","publisher":"Springer Nature","date_created":"2022-01-13T14:12:17Z","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","acknowledgement":"We acknowledge discussions with J. Checkelsky, S. Chen, C. Dean, M. Yankowitz, D. Reilly, I. Sodemann and M. Zaletel. Work at UCSB was primarily supported by the ARO under MURI W911NF-16-1-0361. Measurements of twisted bilayer graphene (Extended Data Fig. 8) and measurements at elevated temperatures (Extended Data Fig. 3) were supported by a SEED grant and made use of shared facilities of the UCSB MRSEC (NSF DMR 1720256), a member of the Materials Research Facilities Network (www.mrfn.org). A.F.Y. acknowledges the support of the David and Lucille Packard Foundation under award 2016-65145. A.H.M. and J.Z. were supported by the National Science Foundation through the Center for Dynamics and Control of Materials, an NSF MRSEC under Cooperative Agreement number DMR-1720595, and by the Welch Foundation under grant TBF1473. C.L.T. acknowledges support from the Hertz Foundation and from the National Science Foundation Graduate Research Fellowship Program under grant 1650114. K.W. and T.T. acknowledge support from the Elemental Strategy Initiative conducted by the MEXT, Japan, Grant Number JPMXP0112101001, JSPS KAKENHI grant numbers JP20H00354 and the CREST(JPMJCR15F3), JST.","fulldoi":"https://doi.org/10.1038/s41586-020-2963-8","publication_status":"published","article_processing_charge":"No","day":"23","extern":"1","date_updated":"2022-01-13T14:21:04Z","arxiv":1,"publication":"Nature","author":[{"first_name":"Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","orcid":"0000-0001-8223-8896","last_name":"Polshyn","full_name":"Polshyn, Hryhoriy"},{"full_name":"Zhu, J.","last_name":"Zhu","first_name":"J."},{"full_name":"Kumar, M. A.","last_name":"Kumar","first_name":"M. A."},{"first_name":"Y.","last_name":"Zhang","full_name":"Zhang, Y."},{"first_name":"F.","last_name":"Yang","full_name":"Yang, F."},{"first_name":"C. L.","full_name":"Tschirhart, C. L.","last_name":"Tschirhart"},{"last_name":"Serlin","full_name":"Serlin, M.","first_name":"M."},{"last_name":"Watanabe","full_name":"Watanabe, K.","first_name":"K."},{"full_name":"Taniguchi, T.","last_name":"Taniguchi","first_name":"T."},{"first_name":"A. H.","last_name":"MacDonald","full_name":"MacDonald, A. H."},{"full_name":"Young, A. F.","last_name":"Young","first_name":"A. F."}],"title":"Electrical switching of magnetic order in an orbital Chern insulator","abstract":[{"text":"Magnetism typically arises from the joint effect of Fermi statistics and repulsive Coulomb interactions, which favours ground states with non-zero electron spin. As a result, controlling spin magnetism with electric fields—a longstanding technological goal in spintronics and multiferroics1,2—can be achieved only indirectly. Here we experimentally demonstrate direct electric-field control of magnetic states in an orbital Chern insulator3,4,5,6, a magnetic system in which non-trivial band topology favours long-range order of orbital angular momentum but the spins are thought to remain disordered7,8,9,10,11,12,13,14. We use van der Waals heterostructures consisting of a graphene monolayer rotationally faulted with respect to a Bernal-stacked bilayer to realize narrow and topologically non-trivial valley-projected moiré minibands15,16,17. At fillings of one and three electrons per moiré unit cell within these bands, we observe quantized anomalous Hall effects18 with transverse resistance approximately equal to h/2e2 (where h is Planck’s constant and e is the charge on the electron), which is indicative of spontaneous polarization of the system into a single-valley-projected band with a Chern number equal to two. At a filling of three electrons per moiré unit cell, we find that the sign of the quantum anomalous Hall effect can be reversed via field-effect control of the chemical potential; moreover, this transition is hysteretic, which we use to demonstrate non-volatile electric-field-induced reversal of the magnetic state. A theoretical analysis19 indicates that the effect arises from the topological edge states, which drive a change in sign of the magnetization and thus a reversal in the favoured magnetic state. Voltage control of magnetic states can be used to electrically pattern non-volatile magnetic-domain structures hosting chiral edge states, with applications ranging from reconfigurable microwave circuit elements to ultralow-power magnetic memories.","lang":"eng"}],"page":"66-70","year":"2020","_id":"10618","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]}},{"fulldoi":"https://doi.org/10.1038/s41586-020-2205-0","user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","publisher":"Springer Nature","date_created":"2021-02-02T13:30:50Z","issue":"7804","article_type":"original","citation":{"ieee":"T. Hueckel, G. M. Hocky, J. A. Palacci, and S. Sacanna, “Ionic solids from common colloids,” <i>Nature</i>, vol. 580, no. 7804. Springer Nature, pp. 487–490, 2020.","ista":"Hueckel T, Hocky GM, Palacci JA, Sacanna S. 2020. Ionic solids from common colloids. Nature. 580(7804), 487–490.","apa":"Hueckel, T., Hocky, G. M., Palacci, J. A., &#38; Sacanna, S. (2020). Ionic solids from common colloids. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-020-2205-0\">https://doi.org/10.1038/s41586-020-2205-0</a>","ama":"Hueckel T, Hocky GM, Palacci JA, Sacanna S. Ionic solids from common colloids. <i>Nature</i>. 2020;580(7804):487-490. doi:<a href=\"https://doi.org/10.1038/s41586-020-2205-0\">10.1038/s41586-020-2205-0</a>","mla":"Hueckel, Theodore, et al. “Ionic Solids from Common Colloids.” <i>Nature</i>, vol. 580, no. 7804, Springer Nature, 2020, pp. 487–90, doi:<a href=\"https://doi.org/10.1038/s41586-020-2205-0\">10.1038/s41586-020-2205-0</a>.","chicago":"Hueckel, Theodore, Glen M. Hocky, Jérémie A Palacci, and Stefano Sacanna. “Ionic Solids from Common Colloids.” <i>Nature</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41586-020-2205-0\">https://doi.org/10.1038/s41586-020-2205-0</a>.","short":"T. Hueckel, G.M. Hocky, J.A. Palacci, S. Sacanna, Nature 580 (2020) 487–490."},"publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"year":"2020","_id":"9059","abstract":[{"lang":"eng","text":"From rock salt to nanoparticle superlattices, complex structure can emerge from simple building blocks that attract each other through Coulombic forces1-4. On the micrometre scale, however, colloids in water defy the intuitively simple idea of forming crystals from oppositely charged partners, instead forming non-equilibrium structures such as clusters and gels5-7. Although various systems have been engineered to grow binary crystals8-11, native surface charge in aqueous conditions has not been used to assemble crystalline materials. Here we form ionic colloidal crystals in water through an approach that we refer to as polymer-attenuated Coulombic self-assembly. The key to crystallization is the use of a neutral polymer to keep particles separated by well defined distances, allowing us to tune the attractive overlap of electrical double layers, directing particles to disperse, crystallize or become permanently fixed on demand. The nucleation and growth of macroscopic single crystals is demonstrated by using the Debye screening length to fine-tune assembly. Using a variety of colloidal particles and commercial polymers, ionic colloidal crystals isostructural to caesium chloride, sodium chloride, aluminium diboride and K4C60 are selected according to particle size ratios. Once fixed by simply diluting out solution salts, crystals are pulled out of the water for further manipulation, demonstrating an accurate translation from solution-phase assembly to dried solid structures. In contrast to other assembly approaches, in which particles must be carefully engineered to encode binding information12-18, polymer-attenuated Coulombic self-assembly enables conventional colloids to be used as model colloidal ions, primed for crystallization. "}],"page":"487-490","publication":"Nature","title":"Ionic solids from common colloids","author":[{"last_name":"Hueckel","full_name":"Hueckel, Theodore","first_name":"Theodore"},{"first_name":"Glen M.","full_name":"Hocky, Glen M.","last_name":"Hocky"},{"full_name":"Palacci, Jérémie A","last_name":"Palacci","orcid":"0000-0002-7253-9465","id":"8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d","first_name":"Jérémie A"},{"last_name":"Sacanna","full_name":"Sacanna, Stefano","first_name":"Stefano"}],"date_updated":"2023-02-23T13:47:55Z","extern":"1","publication_status":"published","day":"23","article_processing_charge":"No","quality_controlled":"1","month":"04","external_id":{"pmid":["32322078"]},"volume":580,"keyword":["Multidisciplinary"],"language":[{"iso":"eng"}],"oa_version":"None","intvolume":"       580","type":"journal_article","date_published":"2020-04-23T00:00:00Z","status":"public","doi":"10.1038/s41586-020-2205-0","scopus_import":"1","pmid":1},{"page":"217-220","abstract":[{"text":"Hydrogen, the simplest and most abundant element in the Universe, develops a remarkably complex behaviour upon compression^1. Since Wigner predicted the dissociation and metallization of solid hydrogen at megabar pressures almost a century ago^2, several efforts have been made to explain the many unusual properties of dense hydrogen, including a rich and poorly understood solid polymorphism^1,3-5, an anomalous melting line6 and the possible transition to a superconducting state^7. Experiments at such extreme conditions are challenging and often lead to hard-to-interpret and controversial observations, whereas theoretical investigations are constrained by the huge computational cost of sufficiently accurate quantum mechanical calculations. Here we present a theoretical study of the phase diagram of dense hydrogen that uses machine learning to 'learn' potential-energy surfaces and interatomic forces from reference calculations and then predict them at low computational cost, overcoming length- and timescale limitations. We reproduce both the re-entrant melting behaviour and the polymorphism of the solid phase. Simulations using our machine-learning-based potentials provide evidence for a continuous molecular-to-atomic transition in the liquid, with no first-order transition observed above the melting line. This suggests a smooth transition between insulating and metallic layers in giant gas planets, and reconciles existing discrepancies between experiments as a manifestation of supercritical behaviour.","lang":"eng"}],"title":"Evidence for supercritical behaviour of high-pressure liquid hydrogen","publication":"Nature","author":[{"last_name":"Cheng","full_name":"Cheng, Bingqing","orcid":"0000-0002-3584-9632","first_name":"Bingqing","id":"cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9"},{"full_name":"Mazzola, Guglielmo","last_name":"Mazzola","first_name":"Guglielmo"},{"first_name":"Chris J.","last_name":"Pickard","full_name":"Pickard, Chris J."},{"full_name":"Ceriotti, Michele","last_name":"Ceriotti","first_name":"Michele"}],"publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"_id":"9685","year":"2020","extern":"1","article_processing_charge":"No","day":"10","publication_status":"published","arxiv":1,"date_updated":"2021-08-09T12:38:01Z","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","date_created":"2021-07-19T09:17:49Z","publisher":"Springer Nature","fulldoi":"https://doi.org/10.1038/s41586-020-2677-y","citation":{"short":"B. Cheng, G. Mazzola, C.J. Pickard, M. Ceriotti, Nature 585 (2020) 217–220.","chicago":"Cheng, Bingqing, Guglielmo Mazzola, Chris J. Pickard, and Michele Ceriotti. “Evidence for Supercritical Behaviour of High-Pressure Liquid Hydrogen.” <i>Nature</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41586-020-2677-y\">https://doi.org/10.1038/s41586-020-2677-y</a>.","ieee":"B. Cheng, G. Mazzola, C. J. Pickard, and M. Ceriotti, “Evidence for supercritical behaviour of high-pressure liquid hydrogen,” <i>Nature</i>, vol. 585, no. 7824. Springer Nature, pp. 217–220, 2020.","mla":"Cheng, Bingqing, et al. “Evidence for Supercritical Behaviour of High-Pressure Liquid Hydrogen.” <i>Nature</i>, vol. 585, no. 7824, Springer Nature, 2020, pp. 217–20, doi:<a href=\"https://doi.org/10.1038/s41586-020-2677-y\">10.1038/s41586-020-2677-y</a>.","apa":"Cheng, B., Mazzola, G., Pickard, C. J., &#38; Ceriotti, M. (2020). Evidence for supercritical behaviour of high-pressure liquid hydrogen. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-020-2677-y\">https://doi.org/10.1038/s41586-020-2677-y</a>","ama":"Cheng B, Mazzola G, Pickard CJ, Ceriotti M. Evidence for supercritical behaviour of high-pressure liquid hydrogen. <i>Nature</i>. 2020;585(7824):217-220. doi:<a href=\"https://doi.org/10.1038/s41586-020-2677-y\">10.1038/s41586-020-2677-y</a>","ista":"Cheng B, Mazzola G, Pickard CJ, Ceriotti M. 2020. Evidence for supercritical behaviour of high-pressure liquid hydrogen. Nature. 585(7824), 217–220."},"oa":1,"article_type":"original","issue":"7824","status":"public","scopus_import":"1","pmid":1,"doi":"10.1038/s41586-020-2677-y","month":"09","quality_controlled":"1","main_file_link":[{"url":"https://arxiv.org/abs/1906.03341","open_access":"1"}],"oa_version":"Preprint","type":"journal_article","date_published":"2020-09-10T00:00:00Z","intvolume":"       585","language":[{"iso":"eng"}],"external_id":{"pmid":["32908269"],"arxiv":["1906.03341"]},"volume":585},{"ec_funded":1,"publication_status":"published","day":"25","article_processing_charge":"No","date_updated":"2026-10-02T22:30:19Z","abstract":[{"text":"Eukaryotic cells migrate by coupling the intracellular force of the actin cytoskeleton to the environment. While force coupling is usually mediated by transmembrane adhesion receptors, especially those of the integrin family, amoeboid cells such as leukocytes can migrate extremely fast despite very low adhesive forces1. Here we show that leukocytes cannot only migrate under low adhesion but can also transmit forces in the complete absence of transmembrane force coupling. When confined within three-dimensional environments, they use the topographical features of the substrate to propel themselves. Here the retrograde flow of the actin cytoskeleton follows the texture of the substrate, creating retrograde shear forces that are sufficient to drive the cell body forwards. Notably, adhesion-dependent and adhesion-independent migration are not mutually exclusive, but rather are variants of the same principle of coupling retrograde actin flow to the environment and thus can potentially operate interchangeably and simultaneously. As adhesion-free migration is independent of the chemical composition of the environment, it renders cells completely autonomous in their locomotive behaviour.","lang":"eng"}],"page":"582–585","publication":"Nature","title":"Cellular locomotion using environmental topography","author":[{"orcid":"0000-0003-0666-8928","first_name":"Anne","id":"35B76592-F248-11E8-B48F-1D18A9856A87","full_name":"Reversat, Anne","last_name":"Reversat"},{"first_name":"Florian R","id":"397A88EE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6120-3723","full_name":"Gärtner, Florian R","last_name":"Gärtner"},{"full_name":"Merrin, Jack","last_name":"Merrin","orcid":"0000-0001-5145-4609","first_name":"Jack","id":"4515C308-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Stopp","full_name":"Stopp, Julian A","first_name":"Julian A","id":"489E3F00-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Saren","id":"4323B49C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1671-393X","full_name":"Tasciyan, Saren","last_name":"Tasciyan"},{"last_name":"Aguilera Servin","full_name":"Aguilera Servin, Juan L","first_name":"Juan L","id":"2A67C376-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2862-8372"},{"first_name":"Ingrid","id":"4C7D837E-F248-11E8-B48F-1D18A9856A87","full_name":"De Vries, Ingrid","last_name":"De Vries"},{"last_name":"Hauschild","full_name":"Hauschild, Robert","orcid":"0000-0001-9843-3522","first_name":"Robert","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-6625-3348","id":"4167FE56-F248-11E8-B48F-1D18A9856A87","first_name":"Miroslav","last_name":"Hons","full_name":"Hons, Miroslav"},{"first_name":"Matthieu","full_name":"Piel, Matthieu","last_name":"Piel"},{"full_name":"Callan-Jones, Andrew","last_name":"Callan-Jones","first_name":"Andrew"},{"last_name":"Voituriez","full_name":"Voituriez, Raphael","first_name":"Raphael"},{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","first_name":"Michael K","orcid":"0000-0002-6620-9179","last_name":"Sixt","full_name":"Sixt, Michael K"}],"publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"year":"2020","_id":"7885","citation":{"chicago":"Reversat, Anne, Florian R Gärtner, Jack Merrin, Julian A Stopp, Saren Tasciyan, Juan L Aguilera Servin, Ingrid de Vries, et al. “Cellular Locomotion Using Environmental Topography.” <i>Nature</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41586-020-2283-z\">https://doi.org/10.1038/s41586-020-2283-z</a>.","short":"A. Reversat, F.R. Gärtner, J. Merrin, J.A. Stopp, S. Tasciyan, J.L. Aguilera Servin, I. de Vries, R. Hauschild, M. Hons, M. Piel, A. Callan-Jones, R. Voituriez, M.K. Sixt, Nature 582 (2020) 582–585.","apa":"Reversat, A., Gärtner, F. R., Merrin, J., Stopp, J. A., Tasciyan, S., Aguilera Servin, J. L., … Sixt, M. K. (2020). Cellular locomotion using environmental topography. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-020-2283-z\">https://doi.org/10.1038/s41586-020-2283-z</a>","mla":"Reversat, Anne, et al. “Cellular Locomotion Using Environmental Topography.” <i>Nature</i>, vol. 582, Springer Nature, 2020, pp. 582–585, doi:<a href=\"https://doi.org/10.1038/s41586-020-2283-z\">10.1038/s41586-020-2283-z</a>.","ama":"Reversat A, Gärtner FR, Merrin J, et al. Cellular locomotion using environmental topography. <i>Nature</i>. 2020;582:582–585. doi:<a href=\"https://doi.org/10.1038/s41586-020-2283-z\">10.1038/s41586-020-2283-z</a>","ista":"Reversat A, Gärtner FR, Merrin J, Stopp JA, Tasciyan S, Aguilera Servin JL, de Vries I, Hauschild R, Hons M, Piel M, Callan-Jones A, Voituriez R, Sixt MK. 2020. Cellular locomotion using environmental topography. Nature. 582, 582–585.","ieee":"A. Reversat <i>et al.</i>, “Cellular locomotion using environmental topography,” <i>Nature</i>, vol. 582. Springer Nature, pp. 582–585, 2020."},"oa":1,"article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Springer Nature","isi":1,"date_created":"2020-05-24T22:01:01Z","fulldoi":"https://doi.org/10.1038/s41586-020-2283-z","acknowledgement":"We thank A. Leithner and J. Renkawitz for discussion and critical reading of the manuscript; J. Schwarz and M. Mehling for establishing the microfluidic setups; the Bioimaging Facility of IST Austria for excellent support, as well as the Life Science Facility and the Miba Machine Shop of IST Austria; and F. N. Arslan, L. E. Burnett and L. Li for their work during their rotation in the IST PhD programme. This work was supported by the European Research Council (ERC StG 281556 and CoG 724373) to M.S. and grants from the Austrian Science Fund (FWF P29911) and the WWTF to M.S. M.H. was supported by the European Regional Development Fund Project (CZ.02.1.01/0.0/0.0/15_003/0000476). F.G. received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 747687.","scopus_import":"1","pmid":1,"doi":"10.1038/s41586-020-2283-z","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"12401"},{"status":"public","relation":"dissertation_contains","id":"14697"}],"link":[{"relation":"press_release","url":"https://ist.ac.at/en/news/off-road-mode-enables-mobile-cells-to-move-freely/","description":"News on IST Homepage"}]},"status":"public","OA_place":"repository","project":[{"grant_number":"281556","_id":"25A603A2-B435-11E9-9278-68D0E5697425","name":"Cytoskeletal force generation and force transduction of migrating leukocytes","call_identifier":"FP7"},{"name":"Cellular Navigation Along Spatial Gradients","_id":"25FE9508-B435-11E9-9278-68D0E5697425","grant_number":"724373","call_identifier":"H2020"},{"call_identifier":"FWF","grant_number":"P29911","name":"Mechanical adaptation of lamellipodial actin","_id":"26018E70-B435-11E9-9278-68D0E5697425"},{"call_identifier":"H2020","_id":"260AA4E2-B435-11E9-9278-68D0E5697425","name":"Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells","grant_number":"747687"}],"department":[{"_id":"NanoFab"},{"_id":"Bio"},{"_id":"MiSi"}],"oa_version":"Preprint","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"M-Shop"}],"intvolume":"       582","date_published":"2020-06-25T00:00:00Z","type":"journal_article","volume":582,"external_id":{"isi":["000532688300008"],"pmid":["32581372"]},"language":[{"iso":"eng"}],"month":"06","OA_type":"green","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/793919"}],"quality_controlled":"1"},{"ec_funded":1,"article_processing_charge":"No","day":"11","publication_status":"published","date_updated":"2025-04-14T07:45:04Z","page":"240-243","abstract":[{"lang":"eng","text":"The plant hormone auxin has crucial roles in almost all aspects of plant growth and development. Concentrations of auxin vary across different tissues, mediating distinct developmental outcomes and contributing to the functional diversity of auxin. However, the mechanisms that underlie these activities are poorly understood. Here we identify an auxin signalling mechanism, which acts in parallel to the canonical auxin pathway based on the transport inhibitor response1 (TIR1) and other auxin receptor F-box (AFB) family proteins (TIR1/AFB receptors)1,2, that translates levels of cellular auxin to mediate differential growth during apical-hook development. This signalling mechanism operates at the concave side of the apical hook, and involves auxin-mediated C-terminal cleavage of transmembrane kinase 1 (TMK1). The cytosolic and nucleus-translocated C terminus of TMK1 specifically interacts with and phosphorylates two non-canonical transcriptional repressors of the auxin or indole-3-acetic acid (Aux/IAA) family (IAA32 and IAA34), thereby regulating ARF transcription factors. In contrast to the degradation of Aux/IAA transcriptional repressors in the canonical pathway, the newly identified mechanism stabilizes the non-canonical IAA32 and IAA34 transcriptional repressors to regulate gene expression and ultimately inhibit growth. The auxin–TMK1 signalling pathway originates at the cell surface, is triggered by high levels of auxin and shares a partially overlapping set of transcription factors with the TIR1/AFB signalling pathway. This allows distinct interpretations of different concentrations of cellular auxin, and thus enables this versatile signalling molecule to mediate complex developmental outcomes."}],"title":"TMK1-mediated auxin signalling regulates differential growth of the apical hook","publication":"Nature","author":[{"first_name":"Min","full_name":"Cao, Min","last_name":"Cao"},{"first_name":"Rong","last_name":"Chen","full_name":"Chen, Rong"},{"full_name":"Li, Pan","last_name":"Li","first_name":"Pan"},{"last_name":"Yu","full_name":"Yu, Yongqiang","first_name":"Yongqiang"},{"first_name":"Rui","full_name":"Zheng, Rui","last_name":"Zheng"},{"first_name":"Danfeng","last_name":"Ge","full_name":"Ge, Danfeng"},{"first_name":"Wei","full_name":"Zheng, Wei","last_name":"Zheng"},{"full_name":"Wang, Xuhui","last_name":"Wang","first_name":"Xuhui"},{"first_name":"Yangtao","full_name":"Gu, Yangtao","last_name":"Gu"},{"last_name":"Gelová","full_name":"Gelová, Zuzana","id":"0AE74790-0E0B-11E9-ABC7-1ACFE5697425","first_name":"Zuzana","orcid":"0000-0003-4783-1752"},{"last_name":"Friml","full_name":"Friml, Jiří","orcid":"0000-0002-8302-7596","first_name":"Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Zhang, Heng","last_name":"Zhang","first_name":"Heng"},{"first_name":"Renyi","last_name":"Liu","full_name":"Liu, Renyi"},{"first_name":"Jun","last_name":"He","full_name":"He, Jun"},{"first_name":"Tongda","last_name":"Xu","full_name":"Xu, Tongda"}],"publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"_id":"6259","year":"2019","file_date_updated":"2020-11-13T07:37:41Z","citation":{"ama":"Cao M, Chen R, Li P, et al. TMK1-mediated auxin signalling regulates differential growth of the apical hook. <i>Nature</i>. 2019;568:240-243. doi:<a href=\"https://doi.org/10.1038/s41586-019-1069-7\">10.1038/s41586-019-1069-7</a>","apa":"Cao, M., Chen, R., Li, P., Yu, Y., Zheng, R., Ge, D., … Xu, T. (2019). TMK1-mediated auxin signalling regulates differential growth of the apical hook. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-019-1069-7\">https://doi.org/10.1038/s41586-019-1069-7</a>","mla":"Cao, Min, et al. “TMK1-Mediated Auxin Signalling Regulates Differential Growth of the Apical Hook.” <i>Nature</i>, vol. 568, Springer Nature, 2019, pp. 240–43, doi:<a href=\"https://doi.org/10.1038/s41586-019-1069-7\">10.1038/s41586-019-1069-7</a>.","ista":"Cao M, Chen R, Li P, Yu Y, Zheng R, Ge D, Zheng W, Wang X, Gu Y, Gelová Z, Friml J, Zhang H, Liu R, He J, Xu T. 2019. TMK1-mediated auxin signalling regulates differential growth of the apical hook. Nature. 568, 240–243.","ieee":"M. Cao <i>et al.</i>, “TMK1-mediated auxin signalling regulates differential growth of the apical hook,” <i>Nature</i>, vol. 568. Springer Nature, pp. 240–243, 2019.","chicago":"Cao, Min, Rong Chen, Pan Li, Yongqiang Yu, Rui Zheng, Danfeng Ge, Wei Zheng, et al. “TMK1-Mediated Auxin Signalling Regulates Differential Growth of the Apical Hook.” <i>Nature</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41586-019-1069-7\">https://doi.org/10.1038/s41586-019-1069-7</a>.","short":"M. Cao, R. Chen, P. Li, Y. Yu, R. Zheng, D. Ge, W. Zheng, X. Wang, Y. Gu, Z. Gelová, J. Friml, H. Zhang, R. Liu, J. He, T. Xu, Nature 568 (2019) 240–243."},"oa":1,"article_type":"original","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_created":"2019-04-09T08:37:05Z","publisher":"Springer Nature","isi":1,"fulldoi":"https://doi.org/10.1038/s41586-019-1069-7","scopus_import":"1","pmid":1,"related_material":{"link":[{"url":"https://ist.ac.at/en/news/newly-discovered-mechanism-of-plant-hormone-auxin-acts-the-opposite-way/","relation":"press_release","description":"News on IST Homepage"}]},"doi":"10.1038/s41586-019-1069-7","status":"public","has_accepted_license":"1","department":[{"_id":"JiFr"}],"project":[{"name":"Tracing Evolution of Auxin Transport and Polarity in Plants","_id":"261099A6-B435-11E9-9278-68D0E5697425","grant_number":"742985","call_identifier":"H2020"}],"oa_version":"Submitted Version","type":"journal_article","date_published":"2019-04-11T00:00:00Z","intvolume":"       568","language":[{"iso":"eng"}],"external_id":{"isi":["000464412700050"],"pmid":["30944466"]},"volume":568,"month":"04","file":[{"date_updated":"2020-11-13T07:37:41Z","file_name":"2019_Nature _Cao_accepted.pdf","content_type":"application/pdf","checksum":"6b84ab602a34382cf0340a37a1378c75","creator":"dernst","file_size":4321328,"relation":"main_file","file_id":"8751","success":1,"access_level":"open_access","date_created":"2020-11-13T07:37:41Z"}],"ddc":["580"],"quality_controlled":"1"},{"month":"04","quality_controlled":"1","main_file_link":[{"url":"https://arxiv.org/abs/1808.10608","open_access":"1"}],"oa_version":"Preprint","intvolume":"       568","date_published":"2019-04-18T00:00:00Z","type":"journal_article","external_id":{"isi":["000464950700053"],"arxiv":["1808.10608"]},"volume":568,"language":[{"iso":"eng"}],"status":"public","department":[{"_id":"JoFi"}],"scopus_import":"1","doi":"10.1038/s41586-019-1110-x","related_material":{"link":[{"url":"https://doi.org/10.1038/s41586-019-1220-5","relation":"erratum"}]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Springer Nature","isi":1,"date_created":"2019-04-28T21:59:13Z","fulldoi":"https://doi.org/10.1038/s41586-019-1110-x","citation":{"ista":"Rueda Sanchez AR, Sedlmeir F, Kumari M, Leuchs G, Schwefel HGL. 2019. Resonant electro-optic frequency comb. Nature. 568(7752), 378–381.","mla":"Rueda Sanchez, Alfredo R., et al. “Resonant Electro-Optic Frequency Comb.” <i>Nature</i>, vol. 568, no. 7752, Springer Nature, 2019, pp. 378–81, doi:<a href=\"https://doi.org/10.1038/s41586-019-1110-x\">10.1038/s41586-019-1110-x</a>.","ama":"Rueda Sanchez AR, Sedlmeir F, Kumari M, Leuchs G, Schwefel HGL. Resonant electro-optic frequency comb. <i>Nature</i>. 2019;568(7752):378-381. doi:<a href=\"https://doi.org/10.1038/s41586-019-1110-x\">10.1038/s41586-019-1110-x</a>","apa":"Rueda Sanchez, A. R., Sedlmeir, F., Kumari, M., Leuchs, G., &#38; Schwefel, H. G. L. (2019). Resonant electro-optic frequency comb. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-019-1110-x\">https://doi.org/10.1038/s41586-019-1110-x</a>","ieee":"A. R. Rueda Sanchez, F. Sedlmeir, M. Kumari, G. Leuchs, and H. G. L. Schwefel, “Resonant electro-optic frequency comb,” <i>Nature</i>, vol. 568, no. 7752. Springer Nature, pp. 378–381, 2019.","short":"A.R. Rueda Sanchez, F. Sedlmeir, M. Kumari, G. Leuchs, H.G.L. Schwefel, Nature 568 (2019) 378–381.","chicago":"Rueda Sanchez, Alfredo R, Florian Sedlmeir, Madhuri Kumari, Gerd Leuchs, and Harald G.L. Schwefel. “Resonant Electro-Optic Frequency Comb.” <i>Nature</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41586-019-1110-x\">https://doi.org/10.1038/s41586-019-1110-x</a>."},"oa":1,"issue":"7752","abstract":[{"lang":"eng","text":"High-speed optical telecommunication is enabled by wavelength-division multiplexing, whereby hundreds of individually stabilized lasers encode information within a single-mode optical fibre. Higher bandwidths require higher total optical power, but the power sent into the fibre is limited by optical nonlinearities within the fibre, and energy consumption by the light sources starts to become a substantial cost factor1. Optical frequency combs have been suggested to remedy this problem by generating numerous discrete, equidistant laser lines within a monolithic device; however, at present their stability and coherence allow them to operate only within small parameter ranges2,3,4. Here we show that a broadband frequency comb realized through the electro-optic effect within a high-quality whispering-gallery-mode resonator can operate at low microwave and optical powers. Unlike the usual third-order Kerr nonlinear optical frequency combs, our combs rely on the second-order nonlinear effect, which is much more efficient. Our result uses a fixed microwave signal that is mixed with an optical-pump signal to generate a coherent frequency comb with a precisely determined carrier separation. The resonant enhancement enables us to work with microwave powers that are three orders of magnitude lower than those in commercially available devices. We emphasize the practical relevance of our results to high rates of data communication. To circumvent the limitations imposed by nonlinear effects in optical communication fibres, one has to solve two problems: to provide a compact and fully integrated, yet high-quality and coherent, frequency comb generator; and to calculate nonlinear signal propagation in real time5. We report a solution to the first problem."}],"page":"378-381","publication":"Nature","title":"Resonant electro-optic frequency comb","author":[{"last_name":"Rueda Sanchez","full_name":"Rueda Sanchez, Alfredo R","id":"3B82B0F8-F248-11E8-B48F-1D18A9856A87","first_name":"Alfredo R","orcid":"0000-0001-6249-5860"},{"full_name":"Sedlmeir, Florian","last_name":"Sedlmeir","first_name":"Florian"},{"last_name":"Kumari","full_name":"Kumari, Madhuri","first_name":"Madhuri"},{"full_name":"Leuchs, Gerd","last_name":"Leuchs","first_name":"Gerd"},{"full_name":"Schwefel, Harald G.L.","last_name":"Schwefel","first_name":"Harald G.L."}],"publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"_id":"6348","year":"2019","publication_status":"published","article_processing_charge":"No","day":"18","arxiv":1,"date_updated":"2025-07-10T11:53:19Z"},{"publication_status":"published","article_processing_charge":"No","day":"06","date_updated":"2025-07-10T11:53:29Z","author":[{"first_name":"Jordi","last_name":"Guiu","full_name":"Guiu, Jordi"},{"last_name":"Hannezo","full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","first_name":"Edouard B"},{"last_name":"Yui","full_name":"Yui, Shiro","first_name":"Shiro"},{"first_name":"Samuel","last_name":"Demharter","full_name":"Demharter, Samuel"},{"full_name":"Ulyanchenko, Svetlana","last_name":"Ulyanchenko","first_name":"Svetlana"},{"last_name":"Maimets","full_name":"Maimets, Martti","first_name":"Martti"},{"first_name":"Anne","full_name":"Jørgensen, Anne","last_name":"Jørgensen"},{"first_name":"Signe","last_name":"Perlman","full_name":"Perlman, Signe"},{"last_name":"Lundvall","full_name":"Lundvall, Lene","first_name":"Lene"},{"last_name":"Mamsen","full_name":"Mamsen, Linn Salto","first_name":"Linn Salto"},{"first_name":"Agnete","full_name":"Larsen, Agnete","last_name":"Larsen"},{"last_name":"Olesen","full_name":"Olesen, Rasmus H.","first_name":"Rasmus H."},{"first_name":"Claus Yding","full_name":"Andersen, Claus Yding","last_name":"Andersen"},{"full_name":"Thuesen, Lea Langhoff","last_name":"Thuesen","first_name":"Lea Langhoff"},{"last_name":"Hare","full_name":"Hare, Kristine Juul","first_name":"Kristine Juul"},{"last_name":"Pers","full_name":"Pers, Tune H.","first_name":"Tune H."},{"first_name":"Konstantin","full_name":"Khodosevich, Konstantin","last_name":"Khodosevich"},{"full_name":"Simons, Benjamin D.","last_name":"Simons","first_name":"Benjamin D."},{"last_name":"Jensen","full_name":"Jensen, Kim B.","first_name":"Kim B."}],"title":"Tracing the origin of adult intestinal stem cells","publication":"Nature","abstract":[{"text":"Adult intestinal stem cells are located at the bottom of crypts of Lieberkühn, where they express markers such as LGR5 1,2 and fuel the constant replenishment of the intestinal epithelium1. Although fetal LGR5-expressing cells can give rise to adult intestinal stem cells3,4, it remains unclear whether this population in the patterned epithelium represents unique intestinal stem-cell precursors. Here we show, using unbiased quantitative lineage-tracing approaches, biophysical modelling and intestinal transplantation, that all cells of the mouse intestinal epithelium—irrespective of their location and pattern of LGR5 expression in the fetal gut tube—contribute actively to the adult intestinal stem cell pool. Using 3D imaging, we find that during fetal development the villus undergoes gross remodelling and fission. This brings epithelial cells from the non-proliferative villus into the proliferative intervillus region, which enables them to contribute to the adult stem-cell niche. Our results demonstrate that large-scale remodelling of the intestinal wall and cell-fate specification are closely linked. Moreover, these findings provide a direct link between the observed plasticity and cellular reprogramming of differentiating cells in adult tissues following damage5,6,7,8,9, revealing that stem-cell identity is an induced rather than a hardwired property.","lang":"eng"}],"page":"107-111","year":"2019","_id":"6513","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"oa":1,"citation":{"short":"J. Guiu, E.B. Hannezo, S. Yui, S. Demharter, S. Ulyanchenko, M. Maimets, A. Jørgensen, S. Perlman, L. Lundvall, L.S. Mamsen, A. Larsen, R.H. Olesen, C.Y. Andersen, L.L. Thuesen, K.J. Hare, T.H. Pers, K. Khodosevich, B.D. Simons, K.B. Jensen, Nature 570 (2019) 107–111.","chicago":"Guiu, Jordi, Edouard B Hannezo, Shiro Yui, Samuel Demharter, Svetlana Ulyanchenko, Martti Maimets, Anne Jørgensen, et al. “Tracing the Origin of Adult Intestinal Stem Cells.” <i>Nature</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41586-019-1212-5\">https://doi.org/10.1038/s41586-019-1212-5</a>.","ieee":"J. Guiu <i>et al.</i>, “Tracing the origin of adult intestinal stem cells,” <i>Nature</i>, vol. 570. Springer Nature, pp. 107–111, 2019.","ista":"Guiu J, Hannezo EB, Yui S, Demharter S, Ulyanchenko S, Maimets M, Jørgensen A, Perlman S, Lundvall L, Mamsen LS, Larsen A, Olesen RH, Andersen CY, Thuesen LL, Hare KJ, Pers TH, Khodosevich K, Simons BD, Jensen KB. 2019. Tracing the origin of adult intestinal stem cells. Nature. 570, 107–111.","apa":"Guiu, J., Hannezo, E. B., Yui, S., Demharter, S., Ulyanchenko, S., Maimets, M., … Jensen, K. B. (2019). Tracing the origin of adult intestinal stem cells. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-019-1212-5\">https://doi.org/10.1038/s41586-019-1212-5</a>","ama":"Guiu J, Hannezo EB, Yui S, et al. Tracing the origin of adult intestinal stem cells. <i>Nature</i>. 2019;570:107-111. doi:<a href=\"https://doi.org/10.1038/s41586-019-1212-5\">10.1038/s41586-019-1212-5</a>","mla":"Guiu, Jordi, et al. “Tracing the Origin of Adult Intestinal Stem Cells.” <i>Nature</i>, vol. 570, Springer Nature, 2019, pp. 107–11, doi:<a href=\"https://doi.org/10.1038/s41586-019-1212-5\">10.1038/s41586-019-1212-5</a>."},"article_type":"original","publisher":"Springer Nature","isi":1,"date_created":"2019-06-02T21:59:14Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","fulldoi":"https://doi.org/10.1038/s41586-019-1212-5","pmid":1,"scopus_import":"1","doi":"10.1038/s41586-019-1212-5","department":[{"_id":"EdHa"}],"status":"public","intvolume":"       570","date_published":"2019-06-06T00:00:00Z","type":"journal_article","oa_version":"Submitted Version","external_id":{"isi":["000470149000048"],"pmid":["31092921"]},"volume":570,"language":[{"iso":"eng"}],"month":"06","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986928","open_access":"1"}],"quality_controlled":"1"},{"file_date_updated":"2020-07-14T12:47:42Z","citation":{"ista":"Hauser OP, Hilbe C, Chatterjee K, Nowak MA. 2019. Social dilemmas among unequals. Nature. 572(7770), 524–527.","apa":"Hauser, O. P., Hilbe, C., Chatterjee, K., &#38; Nowak, M. A. (2019). Social dilemmas among unequals. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-019-1488-5\">https://doi.org/10.1038/s41586-019-1488-5</a>","mla":"Hauser, Oliver P., et al. “Social Dilemmas among Unequals.” <i>Nature</i>, vol. 572, no. 7770, Springer Nature, 2019, pp. 524–27, doi:<a href=\"https://doi.org/10.1038/s41586-019-1488-5\">10.1038/s41586-019-1488-5</a>.","ama":"Hauser OP, Hilbe C, Chatterjee K, Nowak MA. Social dilemmas among unequals. <i>Nature</i>. 2019;572(7770):524-527. doi:<a href=\"https://doi.org/10.1038/s41586-019-1488-5\">10.1038/s41586-019-1488-5</a>","ieee":"O. P. Hauser, C. Hilbe, K. Chatterjee, and M. A. Nowak, “Social dilemmas among unequals,” <i>Nature</i>, vol. 572, no. 7770. Springer Nature, pp. 524–527, 2019.","chicago":"Hauser, Oliver P., Christian Hilbe, Krishnendu Chatterjee, and Martin A. Nowak. “Social Dilemmas among Unequals.” <i>Nature</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41586-019-1488-5\">https://doi.org/10.1038/s41586-019-1488-5</a>.","short":"O.P. Hauser, C. Hilbe, K. Chatterjee, M.A. Nowak, Nature 572 (2019) 524–527."},"oa":1,"article_type":"letter_note","issue":"7770","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2019-09-01T22:00:56Z","publisher":"Springer Nature","isi":1,"fulldoi":"https://doi.org/10.1038/s41586-019-1488-5","ec_funded":1,"article_processing_charge":"No","day":"22","publication_status":"published","date_updated":"2025-07-10T11:53:55Z","page":"524-527","abstract":[{"text":"Direct reciprocity is a powerful mechanism for the evolution of cooperation on the basis of repeated interactions1,2,3,4. It requires that interacting individuals are sufficiently equal, such that everyone faces similar consequences when they cooperate or defect. Yet inequality is ubiquitous among humans5,6 and is generally considered to undermine cooperation and welfare7,8,9,10. Most previous models of reciprocity do not include inequality11,12,13,14,15. These models assume that individuals are the same in all relevant aspects. Here we introduce a general framework to study direct reciprocity among unequal individuals. Our model allows for multiple sources of inequality. Subjects can differ in their endowments, their productivities and in how much they benefit from public goods. We find that extreme inequality prevents cooperation. But if subjects differ in productivity, some endowment inequality can be necessary for cooperation to prevail. Our mathematical predictions are supported by a behavioural experiment in which we vary the endowments and productivities of the subjects. We observe that overall welfare is maximized when the two sources of heterogeneity are aligned, such that more productive individuals receive higher endowments. By contrast, when endowments and productivities are misaligned, cooperation quickly breaks down. Our findings have implications for policy-makers concerned with equity, efficiency and the provisioning of public goods.","lang":"eng"}],"publication":"Nature","title":"Social dilemmas among unequals","author":[{"full_name":"Hauser, Oliver P.","last_name":"Hauser","first_name":"Oliver P."},{"full_name":"Hilbe, Christian","last_name":"Hilbe","id":"2FDF8F3C-F248-11E8-B48F-1D18A9856A87","first_name":"Christian","orcid":"0000-0001-5116-955X"},{"full_name":"Chatterjee, Krishnendu","last_name":"Chatterjee","first_name":"Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4561-241X"},{"last_name":"Nowak","full_name":"Nowak, Martin A.","first_name":"Martin A."}],"publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"year":"2019","_id":"6836","oa_version":"Submitted Version","date_published":"2019-08-22T00:00:00Z","type":"journal_article","intvolume":"       572","language":[{"iso":"eng"}],"volume":572,"external_id":{"isi":["000482219600045"]},"month":"08","file":[{"content_type":"application/pdf","creator":"dernst","checksum":"a6e0e3168bf62de624e7772cdfaeb26f","date_updated":"2020-07-14T12:47:42Z","file_name":"2019_Nature_Hauser.pdf","access_level":"open_access","file_id":"7828","date_created":"2020-05-14T10:00:32Z","file_size":18577756,"relation":"main_file"}],"ddc":["000"],"quality_controlled":"1","scopus_import":"1","related_material":{"link":[{"description":"News on IST Homepage","url":"https://ist.ac.at/en/news/too-much-inequality-impedes-support-for-public-goods-according-to-research-published-in-nature/","relation":"press_release"}]},"doi":"10.1038/s41586-019-1488-5","status":"public","has_accepted_license":"1","department":[{"_id":"KrCh"}],"project":[{"grant_number":"279307","_id":"2581B60A-B435-11E9-9278-68D0E5697425","name":"Quantitative Graph Games: Theory and Applications","call_identifier":"FP7"},{"grant_number":"S 11407_N23","_id":"25832EC2-B435-11E9-9278-68D0E5697425","name":"Rigorous Systems Engineering","call_identifier":"FWF"},{"call_identifier":"FP7","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme"}]},{"issue":"7774","article_type":"letter_note","citation":{"chicago":"Rispoli, Matthew, Alexander Lukin, Robert Schittko, Sooshin Kim, M. Eric Tai, Julian Leonard, and Markus Greiner. “Quantum Critical Behaviour at the Many-Body Localization Transition.” <i>Nature</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41586-019-1527-2\">https://doi.org/10.1038/s41586-019-1527-2</a>.","short":"M. Rispoli, A. Lukin, R. Schittko, S. Kim, M.E. Tai, J. Leonard, M. Greiner, Nature 573 (2019) 385–389.","apa":"Rispoli, M., Lukin, A., Schittko, R., Kim, S., Tai, M. E., Leonard, J., &#38; Greiner, M. (2019). Quantum critical behaviour at the many-body localization transition. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-019-1527-2\">https://doi.org/10.1038/s41586-019-1527-2</a>","mla":"Rispoli, Matthew, et al. “Quantum Critical Behaviour at the Many-Body Localization Transition.” <i>Nature</i>, vol. 573, no. 7774, Springer Nature, 2019, pp. 385–89, doi:<a href=\"https://doi.org/10.1038/s41586-019-1527-2\">10.1038/s41586-019-1527-2</a>.","ama":"Rispoli M, Lukin A, Schittko R, et al. Quantum critical behaviour at the many-body localization transition. <i>Nature</i>. 2019;573(7774):385-389. doi:<a href=\"https://doi.org/10.1038/s41586-019-1527-2\">10.1038/s41586-019-1527-2</a>","ista":"Rispoli M, Lukin A, Schittko R, Kim S, Tai ME, Leonard J, Greiner M. 2019. Quantum critical behaviour at the many-body localization transition. Nature. 573(7774), 385–389.","ieee":"M. Rispoli <i>et al.</i>, “Quantum critical behaviour at the many-body localization transition,” <i>Nature</i>, vol. 573, no. 7774. Springer Nature, pp. 385–389, 2019."},"oa":1,"fulldoi":"https://doi.org/10.1038/s41586-019-1527-2","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Springer Nature","date_created":"2024-10-07T11:48:26Z","date_updated":"2024-10-08T09:33:30Z","arxiv":1,"extern":"1","publication_status":"published","article_processing_charge":"No","day":"04","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"_id":"18195","year":"2019","abstract":[{"lang":"eng","text":"Phase transitions are driven by collective fluctuations of a system’s constituents that emerge at a critical point1. This mechanism has been extensively explored for classical and quantum systems in equilibrium, whose critical behaviour is described by the general theory of phase transitions. Recently, however, fundamentally distinct phase transitions have been discovered for out-of-equilibrium quantum systems, which can exhibit critical behaviour that defies this description and is not well understood1. A paradigmatic example is the many-body localization (MBL) transition, which marks the breakdown of thermalization in an isolated quantum many-body system as its disorder increases beyond a critical value2,3,4,5,6,7,8,9,10,11. Characterizing quantum critical behaviour in an MBL system requires probing its entanglement over space and time4,5,7, which has proved experimentally challenging owing to stringent requirements on quantum state preparation and system isolation. Here we observe quantum critical behaviour at the MBL transition in a disordered Bose–Hubbard system and characterize its entanglement via its multi-point quantum correlations. We observe the emergence of strong correlations, accompanied by the onset of anomalous diffusive transport throughout the system, and verify their critical nature by measuring their dependence on the system size. The correlations extend to high orders in the quantum critical regime and appear to form via a sparse network of many-body resonances that spans the entire system12,13. Our results connect the macroscopic phenomenology of the transition to the system’s microscopic structure of quantum correlations, and they provide an essential step towards understanding criticality and universality in non-equilibrium systems1,7,13."}],"page":"385-389","author":[{"first_name":"Matthew","last_name":"Rispoli","full_name":"Rispoli, Matthew"},{"full_name":"Lukin, Alexander","last_name":"Lukin","first_name":"Alexander"},{"first_name":"Robert","full_name":"Schittko, Robert","last_name":"Schittko"},{"first_name":"Sooshin","last_name":"Kim","full_name":"Kim, Sooshin"},{"first_name":"M. Eric","full_name":"Tai, M. Eric","last_name":"Tai"},{"full_name":"Leonard, Julian","last_name":"Leonard","first_name":"Julian","id":"b75b3f45-7995-11ef-9bfd-9a9cd02c3577"},{"first_name":"Markus","full_name":"Greiner, Markus","last_name":"Greiner"}],"title":"Quantum critical behaviour at the many-body localization transition","publication":"Nature","external_id":{"arxiv":["1812.06959"],"pmid":["31485075"]},"volume":573,"language":[{"iso":"eng"}],"oa_version":"Preprint","intvolume":"       573","date_published":"2019-09-04T00:00:00Z","type":"journal_article","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.1812.06959"}],"quality_controlled":"1","month":"09","doi":"10.1038/s41586-019-1527-2","scopus_import":"1","pmid":1,"status":"public"}]