[{"acknowledgement":"We thank Ł. Koziej for processing of the initial cryo-EM datasets, S. Schmelz for support in cryo-EM, A. Gatzemeier for assistance in the purification of dBa1Cas12a3, R. Rarose for support with the in vitro RNA experiments, M. Kaminski for providing purified PsmCas13b protein, L. Schönemann for protein purification, and C. Krempl and S. Backesfor providing the RSV and influenza A transcript-encoding plasmids. This work was supported through funding by the European Research Council (101001394 to S.G.; 865973 and 101158249 to C.L.B.), the R. Gaurth Hansen Family (to R.N.J.), the National Institutes of Health (R35GM138080 to R.N.J.), the PostDoc Plus Program from the Graduate School of Life Sciences at Julius-Maximilians-Universität Würzburg (to O.D.), and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy–The Berlin Mathematics Research Center MATH+ (EXC−2046/1, project ID: 390685689 to M.v.K.). Open access funding provided by Helmholtz-Zentrum für Infektionsforschung GmbH (HZI).","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"doi":"10.1038/s41586-025-09852-9","department":[{"_id":"JaBr"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"OA_place":"publisher","date_updated":"2026-01-12T10:13:56Z","author":[{"first_name":"Oleg","full_name":"Dmytrenko, Oleg","last_name":"Dmytrenko"},{"first_name":"Biao","last_name":"Yuan","full_name":"Yuan, Biao"},{"first_name":"Kadin T.","last_name":"Crosby","full_name":"Crosby, Kadin T."},{"first_name":"Max","last_name":"Krebel","full_name":"Krebel, Max"},{"first_name":"Xiye","last_name":"Chen","full_name":"Chen, Xiye"},{"first_name":"Jakub S.","full_name":"Nowak, Jakub S.","last_name":"Nowak"},{"full_name":"Chramiec-Głąbik, Andrzej","last_name":"Chramiec-Głąbik","first_name":"Andrzej"},{"first_name":"Bamidele","full_name":"Filani, Bamidele","last_name":"Filani"},{"last_name":"Gribling-Burrer","full_name":"Gribling-Burrer, Anne-Sophie","first_name":"Anne-Sophie"},{"full_name":"van der Toorn, Wiep","last_name":"van der Toorn","first_name":"Wiep"},{"full_name":"von Kleist, Max","last_name":"von Kleist","first_name":"Max"},{"first_name":"Tatjana","last_name":"Achmedov","full_name":"Achmedov, Tatjana"},{"full_name":"Smyth, Redmond P.","last_name":"Smyth","first_name":"Redmond P."},{"last_name":"Glatt","full_name":"Glatt, Sebastian","first_name":"Sebastian"},{"orcid":"0000-0003-0456-0753","first_name":"Jack Peter Kelly","last_name":"Bravo","id":"96aecfa5-8931-11ee-af30-aa6a5d6eee0e","full_name":"Bravo, Jack Peter Kelly"},{"first_name":"Dirk W.","full_name":"Heinz, Dirk W.","last_name":"Heinz"},{"full_name":"Jackson, Ryan N.","last_name":"Jackson","first_name":"Ryan N."},{"first_name":"Chase L.","last_name":"Beisel","full_name":"Beisel, Chase L."}],"date_published":"2026-01-07T00:00:00Z","ddc":["570"],"scopus_import":"1","oa_version":"Published Version","has_accepted_license":"1","month":"01","PlanS_conform":"1","external_id":{"pmid":["41501459"]},"language":[{"iso":"eng"}],"citation":{"ista":"Dmytrenko O, Yuan B, Crosby KT, Krebel M, Chen X, Nowak JS, Chramiec-Głąbik A, Filani B, Gribling-Burrer A-S, van der Toorn W, von Kleist M, Achmedov T, Smyth RP, Glatt S, Bravo JPK, Heinz DW, Jackson RN, Beisel CL. 2026. RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity. Nature.","ama":"Dmytrenko O, Yuan B, Crosby KT, et al. RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity. <i>Nature</i>. 2026. doi:<a href=\"https://doi.org/10.1038/s41586-025-09852-9\">10.1038/s41586-025-09852-9</a>","chicago":"Dmytrenko, Oleg, Biao Yuan, Kadin T. Crosby, Max Krebel, Xiye Chen, Jakub S. Nowak, Andrzej Chramiec-Głąbik, et al. “RNA-Triggered Cas12a3 Cleaves TRNA Tails to Execute Bacterial Immunity.” <i>Nature</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41586-025-09852-9\">https://doi.org/10.1038/s41586-025-09852-9</a>.","apa":"Dmytrenko, O., Yuan, B., Crosby, K. T., Krebel, M., Chen, X., Nowak, J. S., … Beisel, C. L. (2026). RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-025-09852-9\">https://doi.org/10.1038/s41586-025-09852-9</a>","short":"O. Dmytrenko, B. Yuan, K.T. Crosby, M. Krebel, X. Chen, J.S. Nowak, A. Chramiec-Głąbik, B. Filani, A.-S. Gribling-Burrer, W. van der Toorn, M. von Kleist, T. Achmedov, R.P. Smyth, S. Glatt, J.P.K. Bravo, D.W. Heinz, R.N. Jackson, C.L. Beisel, Nature (2026).","ieee":"O. Dmytrenko <i>et al.</i>, “RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity,” <i>Nature</i>. Springer Nature, 2026.","mla":"Dmytrenko, Oleg, et al. “RNA-Triggered Cas12a3 Cleaves TRNA Tails to Execute Bacterial Immunity.” <i>Nature</i>, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41586-025-09852-9\">10.1038/s41586-025-09852-9</a>."},"oa":1,"quality_controlled":"1","article_type":"original","date_created":"2026-01-08T07:57:17Z","year":"2026","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity","main_file_link":[{"url":"https://doi.org/10.1038/s41586-025-09852-9","open_access":"1"}],"abstract":[{"lang":"eng","text":"In all domains of life, tRNAs mediate the transfer of genetic information from mRNAs to proteins. As their depletion suppresses translation and, consequently, viral replication, tRNAs represent long-standing and increasingly recognized targets of innate immunity1,2,3,4,5. Here we report Cas12a3 effector nucleases from type V CRISPR–Cas adaptive immune systems in bacteria that preferentially cleave tRNAs after recognition of target RNA. Cas12a3 orthologues belong to one of two previously unreported nuclease clades that exhibit RNA-mediated cleavage of non-target RNA, and are distinct from all other known type V systems. Through cell-based and biochemical assays and direct RNA sequencing, we demonstrate that recognition of a complementary target RNA by the CRISPR RNA triggers Cas12a3 to cleave the conserved 5′-CCA-3′ tail of diverse tRNAs to drive growth arrest and anti-phage defence. Cryogenic electron microscopy structures further revealed a distinct tRNA-loading domain that positions the tRNA tail in the RuvC active site of the nuclease. By designing synthetic reporters that mimic the tRNA acceptor stem and tail, we expanded the capacity of current CRISPR-based diagnostics for multiplexed RNA detection. Overall, these findings reveal widespread tRNA inactivation as a previously unrecognized CRISPR-based immune strategy that broadens the application space of the existing CRISPR toolbox."}],"_id":"20963","pmid":1,"status":"public","publication_status":"epub_ahead","day":"07","type":"journal_article","OA_type":"hybrid","article_processing_charge":"Yes (via OA deal)","publication":"Nature","publisher":"Springer Nature"},{"department":[{"_id":"ScWa"},{"_id":"GradSch"},{"_id":"LifeSc"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"acknowledgement":"This project has received support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 949120) and from the Marie Skłodowska-Curie programme (grant agreement no. 754411). We acknowledge the state of Lower Austria and the European Regional Development Fund under grant no. WST3-F-542638/004-2021. N.M. acknowledges support from grant Fondecyt 1221597. G.G. is a Serra Húnter fellow. This research was supported by the Scientific Service Units of the Institute of Science and Technology Austria through resources provided by the Miba Machine Shop, Nanofabrication Facility, Scientific Computing facility and Lab Support Facility. We thank the Modic group for the use of the Laue camera, T. Zauner for the photography of the experimental set-up and R. Möller for insightful discussions. Open access funding provided by Institute of Science and Technology (IST Austria).","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"doi":"10.1038/s41586-025-10088-w","oa_version":"Published Version","has_accepted_license":"1","month":"03","PlanS_conform":"1","external_id":{"pmid":["41851325"]},"language":[{"iso":"eng"}],"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"},{"_id":"ScienComp"},{"_id":"LifeSc"}],"OA_place":"publisher","date_updated":"2026-03-24T06:59:57Z","project":[{"grant_number":"949120","name":"Tribocharge: a multi-scale approach to an enduring problem in physics","call_identifier":"H2020","_id":"0aa60e99-070f-11eb-9043-a6de6bdc3afa"},{"call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411"}],"author":[{"full_name":"Grosjean, Galien M","last_name":"Grosjean","id":"0C5FDA4A-9CF6-11E9-8939-FF05E6697425","first_name":"Galien M","orcid":"0000-0001-5154-417X"},{"first_name":"Markus","full_name":"Ostermann, Markus","last_name":"Ostermann"},{"first_name":"Markus","last_name":"Sauer","full_name":"Sauer, Markus"},{"last_name":"Hahn","full_name":"Hahn, Michael","first_name":"Michael"},{"full_name":"Pichler, Christian M.","last_name":"Pichler","first_name":"Christian M."},{"full_name":"Fahrnberger, Florian","last_name":"Fahrnberger","first_name":"Florian"},{"first_name":"Felix","orcid":"0000-0003-0463-5794","id":"6313aec0-15b2-11ec-abd3-ed67d16139af","last_name":"Pertl","full_name":"Pertl, Felix"},{"first_name":"Daniel","orcid":"0000-0001-7597-043X","last_name":"Balazs","full_name":"Balazs, Daniel","id":"302BADF6-85FC-11EA-9E3B-B9493DDC885E"},{"last_name":"Link","full_name":"Link, Mason M.","first_name":"Mason M."},{"last_name":"Kim","full_name":"Kim, Seong H.","first_name":"Seong H."},{"first_name":"Devin L.","full_name":"Schrader, Devin L.","last_name":"Schrader"},{"last_name":"Blanco","full_name":"Blanco, Adriana","first_name":"Adriana"},{"first_name":"Francisco","last_name":"Gracia","full_name":"Gracia, Francisco"},{"full_name":"Mujica, Nicolás","last_name":"Mujica","first_name":"Nicolás"},{"orcid":"0000-0002-2299-3176","first_name":"Scott R","last_name":"Waitukaitis","full_name":"Waitukaitis, Scott R","id":"3A1FFC16-F248-11E8-B48F-1D18A9856A87"}],"date_published":"2026-03-18T00:00:00Z","ddc":["540"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2026-03-24T06:57:08Z","title":"Adventitious carbon breaks symmetry in oxide contact electrification","ec_funded":1,"citation":{"ama":"Grosjean GM, Ostermann M, Sauer M, et al. Adventitious carbon breaks symmetry in oxide contact electrification. <i>Nature</i>. 2026;651(8106):626-631. doi:<a href=\"https://doi.org/10.1038/s41586-025-10088-w\">10.1038/s41586-025-10088-w</a>","ista":"Grosjean GM, Ostermann M, Sauer M, Hahn M, Pichler CM, Fahrnberger F, Pertl F, Balazs D, Link MM, Kim SH, Schrader DL, Blanco A, Gracia F, Mujica N, Waitukaitis SR. 2026. Adventitious carbon breaks symmetry in oxide contact electrification. Nature. 651(8106), 626–631.","apa":"Grosjean, G. M., Ostermann, M., Sauer, M., Hahn, M., Pichler, C. M., Fahrnberger, F., … Waitukaitis, S. R. (2026). Adventitious carbon breaks symmetry in oxide contact electrification. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-025-10088-w\">https://doi.org/10.1038/s41586-025-10088-w</a>","chicago":"Grosjean, Galien M, Markus Ostermann, Markus Sauer, Michael Hahn, Christian M. Pichler, Florian Fahrnberger, Felix Pertl, et al. “Adventitious Carbon Breaks Symmetry in Oxide Contact Electrification.” <i>Nature</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41586-025-10088-w\">https://doi.org/10.1038/s41586-025-10088-w</a>.","mla":"Grosjean, Galien M., et al. “Adventitious Carbon Breaks Symmetry in Oxide Contact Electrification.” <i>Nature</i>, vol. 651, no. 8106, Springer Nature, 2026, pp. 626–31, doi:<a href=\"https://doi.org/10.1038/s41586-025-10088-w\">10.1038/s41586-025-10088-w</a>.","short":"G.M. Grosjean, M. Ostermann, M. Sauer, M. Hahn, C.M. Pichler, F. Fahrnberger, F. Pertl, D. Balazs, M.M. Link, S.H. Kim, D.L. Schrader, A. Blanco, F. Gracia, N. Mujica, S.R. Waitukaitis, Nature 651 (2026) 626–631.","ieee":"G. M. Grosjean <i>et al.</i>, “Adventitious carbon breaks symmetry in oxide contact electrification,” <i>Nature</i>, vol. 651, no. 8106. Springer Nature, pp. 626–631, 2026."},"oa":1,"corr_author":"1","quality_controlled":"1","article_type":"original","date_created":"2026-03-23T15:04:00Z","year":"2026","volume":651,"day":"18","page":"626-631","type":"journal_article","OA_type":"hybrid","article_processing_charge":"Yes (via OA deal)","issue":"8106","publication":"Nature","publisher":"Springer Nature","pmid":1,"_id":"21485","abstract":[{"text":"Insulating oxides are among the most abundant solid materials in the universe1,2,3. Of the many ways in which they influence natural phenomena, perhaps the most consequential is their capacity to transfer electrical charge during contact4,5,6,7,8,9,10—which occurs even between samples of the same oxide—yet the symmetry-breaking parameter that causes this remains unidentified11,12. Here we show that adventitious carbonaceous molecules adsorbed from the environment are the symmetry-breaking factor in same-material oxide contact electrification (CE). We use acoustic levitation to measure charge exchange between a sphere and a plate composed of identical amorphous silicon dioxide (SiO2). Although charging polarity is random for co-prepared samples, we control it with baking or plasma treatment. Observing the charge-exchange relaxation afterwards, we see dynamics over a timescale of hours and connect this directly to the presence of adventitious carbon with time-of-flight mass spectrometry, low-energy ion scattering and infrared spectroscopy. Going further, we confirm that adventitious carbon can even determine charge exchange among different oxides. Our results identify the symmetry-breaking parameter that causes insulating oxides to exchange charge in settings ranging from desert sands4 to volcanic plumes5,6, while simultaneously highlighting an overlooked factor in CE more broadly.","lang":"eng"}],"intvolume":"       651","status":"public","publication_status":"published","file":[{"relation":"main_file","content_type":"application/pdf","date_created":"2026-03-24T06:57:08Z","file_name":"2026_Nature_Grosjean.pdf","success":1,"creator":"dernst","date_updated":"2026-03-24T06:57:08Z","file_size":12245694,"checksum":"dafef9ed575b44be4263e948a47ae056","file_id":"21494","access_level":"open_access"}]},{"external_id":{"pmid":["40702175"]},"language":[{"iso":"eng"}],"has_accepted_license":"1","scopus_import":"1","oa_version":"Published Version","month":"07","author":[{"first_name":"Felix","last_name":"Baier","full_name":"Baier, Felix"},{"first_name":"Katja","full_name":"Reinhard, Katja","last_name":"Reinhard"},{"full_name":"Nuttin, Bram","last_name":"Nuttin","first_name":"Bram"},{"first_name":"Arnau","full_name":"Sans-Dublanc, Arnau","last_name":"Sans-Dublanc"},{"first_name":"Chen","last_name":"Liu","full_name":"Liu, Chen"},{"first_name":"Victoria","last_name":"Tong","full_name":"Tong, Victoria"},{"last_name":"Murmann","full_name":"Murmann, Julie Stefanie","id":"1d390868-f128-11eb-9611-a0ca5f7833b5","first_name":"Julie Stefanie"},{"first_name":"Keimpe","full_name":"Wierda, Keimpe","last_name":"Wierda"},{"first_name":"Karl","full_name":"Farrow, Karl","last_name":"Farrow"},{"first_name":"Hopi E.","full_name":"Hoekstra, Hopi E.","last_name":"Hoekstra"}],"ddc":["570"],"date_published":"2025-07-23T00:00:00Z","date_updated":"2026-01-05T11:38:40Z","OA_place":"publisher","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png"},"department":[{"_id":"GradSch"}],"doi":"10.1038/s41586-025-09241-2","acknowledgement":"The authors thank M. Yilmaz, M. Meister, M. Joesch and T. Branco for advice on the behavioural experiments; C. Dulac, V. Bitsikas, E. Diel and J. Chen for advice on the immunohistochemistry and RNAscope experiments; J. Greenwood and E. Soucy for technical and engineering help; A. Chrzanowska for help and advice on optogenetic experiments; A. Calzoni for help aligning histological sections to a brain atlas; S. Worthington for statistical advice; P. Gonçalves for advice with the electrophysiology analysis; I. Vlaemick for help with whole cell experiments; R. Hellmiss for figure design; B. Sabatini, V. Stempel, K. Tyssowski and N. Sanguinetti for feedback on the manuscript; and Y. M. Lee and A. Tomcho for photos of P. maniculatus and P. leucopus habitats (Fig. 1). F.B. was supported by an HHMI International Student Research Fellowship, a Grant-in-Aid of the American Society of Mammalogy, a Herchel Smith Graduate Fellowship, a Robert A. Chapman Memorial Scholarship, and a Joan Brockman Williamson Fellowship. This project received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement 665501 and by the FWO (12S7917N and 12S7920N) to K.R. and from European Research Council (ERC) (grant agreement 101075848) to K.R. V.T. was supported by a Harvard PRISE fellowship and a Harvard Museum of Comparative Zoology grant for undergraduate research. K.F. is supported by the FWO (G094616N and G091719N) and the NIH (1R01EY032101). This work was supported by the Howard Hughes Medical Institute, of which H.E.H. was an Investigator.","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"article_processing_charge":"Yes (in subscription journal)","OA_type":"hybrid","publisher":"Springer Nature","publication":"Nature","page":"439-447","day":"23","volume":645,"type":"journal_article","file":[{"access_level":"open_access","file_id":"20884","file_size":53301589,"checksum":"7ea846a7a49b3b2a248f6a27ab13d591","date_updated":"2025-12-30T07:39:45Z","success":1,"creator":"dernst","date_created":"2025-12-30T07:39:45Z","file_name":"2025_Nature_Baier.pdf","content_type":"application/pdf","relation":"main_file"}],"publication_status":"published","status":"public","pmid":1,"_id":"20101","abstract":[{"text":"Evading imminent threat from predators is critical for animal survival. Effective defensive strategies can vary, even between closely related species. However, the neural basis of such species-specific behaviours remains poorly understood1,2,3,4. Here we find that two sister species of deer mice (genus Peromyscus)5 show different responses to the same looming stimulus: Peromyscus maniculatus, which occupies densely vegetated habitats, predominantly escapes, whereas the open field specialist, Peromyscus polionotus, briefly freezes. This difference arises from species-specific escape thresholds, is largely context-independent, and can be triggered by both visual and auditory threat stimuli. Using immunohistochemistry and electrophysiological recordings, we find that although visual threat activates the superior colliculus in both species, the role of the dorsal periaqueductal grey (dPAG) in driving behaviour differs. Whereas dPAG activity scales with running speed in P. maniculatus, neural activity in the dPAG of P. polionotus correlates poorly with movement, including during visually triggered escape. Moreover, optogenetic activation of dPAG neurons elicits acceleration in P. maniculatus but not in P. polionotus, and their chemogenetic inhibition during a looming stimulus delays escape onset in P. maniculatus to match that of P. polionotus. Together, we trace species-specific escape thresholds to a central circuit node, downstream of peripheral sensory neurons, localizing an ecologically relevant behavioural difference to a specific region of the mammalian brain.","lang":"eng"}],"intvolume":"       645","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","related_material":{"record":[{"status":"public","relation":"research_data","id":"20883"}]},"title":"The neural basis of species-specific defensive behaviour in Peromyscus mice","file_date_updated":"2025-12-30T07:39:45Z","article_type":"original","quality_controlled":"1","year":"2025","date_created":"2025-08-03T22:01:31Z","citation":{"mla":"Baier, Felix, et al. “The Neural Basis of Species-Specific Defensive Behaviour in Peromyscus Mice.” <i>Nature</i>, vol. 645, Springer Nature, 2025, pp. 439–47, doi:<a href=\"https://doi.org/10.1038/s41586-025-09241-2\">10.1038/s41586-025-09241-2</a>.","ieee":"F. Baier <i>et al.</i>, “The neural basis of species-specific defensive behaviour in Peromyscus mice,” <i>Nature</i>, vol. 645. Springer Nature, pp. 439–447, 2025.","short":"F. Baier, K. Reinhard, B. Nuttin, A. Sans-Dublanc, C. Liu, V. Tong, J.S. Murmann, K. Wierda, K. Farrow, H.E. Hoekstra, Nature 645 (2025) 439–447.","apa":"Baier, F., Reinhard, K., Nuttin, B., Sans-Dublanc, A., Liu, C., Tong, V., … Hoekstra, H. E. (2025). The neural basis of species-specific defensive behaviour in Peromyscus mice. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-025-09241-2\">https://doi.org/10.1038/s41586-025-09241-2</a>","chicago":"Baier, Felix, Katja Reinhard, Bram Nuttin, Arnau Sans-Dublanc, Chen Liu, Victoria Tong, Julie Stefanie Murmann, Keimpe Wierda, Karl Farrow, and Hopi E. Hoekstra. “The Neural Basis of Species-Specific Defensive Behaviour in Peromyscus Mice.” <i>Nature</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41586-025-09241-2\">https://doi.org/10.1038/s41586-025-09241-2</a>.","ama":"Baier F, Reinhard K, Nuttin B, et al. The neural basis of species-specific defensive behaviour in Peromyscus mice. <i>Nature</i>. 2025;645:439-447. doi:<a href=\"https://doi.org/10.1038/s41586-025-09241-2\">10.1038/s41586-025-09241-2</a>","ista":"Baier F, Reinhard K, Nuttin B, Sans-Dublanc A, Liu C, Tong V, Murmann JS, Wierda K, Farrow K, Hoekstra HE. 2025. The neural basis of species-specific defensive behaviour in Peromyscus mice. Nature. 645, 439–447."},"oa":1},{"doi":"10.1038/s41586-025-09549-z","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"acknowledgement":"We thank P. J. Y. Leung, K. L. Shelley, A. Pillai, C. Demakis, M. Exposit, K. Thompson, C. Savvides, R. J. Ragotte, G. Ahn and M. Glögl for discussions and technical support; K. VanWormer and L. Goldschmidt for technical support; S. R. Gerben and A. Murray for protein production support; and X. Li, M. Lamb, Z. Taylor and V. Adebomi for LC–MS support. This work was supported by the Audacious Project at the Institute for Protein Design (A.J.B., A.K., J.D.L.C., E.B. and A.K.B.); by a gift from Microsoft (A.J.B.); by the Nordstrom Barrier Institute for Protein Design Directors Fund (M.H.A. and F.P.); by Bill and Melinda Gates Foundation OPP1156262 (A.K. and J.D.L.C.); by the Open Philanthropy Project Improving Protein Design Fund (E.B. and A.K.B.); by the National Institutes of Health (NIH) National Institute of Allergy and Infectious Disease grant R0AI160052 (A.K.B.); by CRI Irvington Postdoctoral Fellowship 315511 (Y.Z.); by National Cancer Institute K00 award 4K00CA274708 (M.O.); by National Science Foundation grant MCB 2119837 and NIH grant GM115805 (W.H.R. and D.M.Z.); by NIH grant GM151956 (S.S.); by NIH AI-51321 (K.C.G.); by the DFG grants PI 405/15 and SFB 1557 (C.P. and J.P.); and by the Howard Hughes Medical Institute (A.K.B., K.C.G. and D.B.). The EPR spectrometer used for the DEER experiments was in part supported by NIH grant S10OD021557. This research used resources (FMX/AMX) of the National Synchrotron Light Source II, a US Department of Energy (DoE) Office of Science User Facility operated for the DOE Office of Science by Brookhaven National Laboratory under contract DE-SC0012704. The Center for BioMolecular Structure (CBMS) is supported mainly by the NIH National Institute of General Medical Sciences (NIGMS) through a Center Core P30 Grant (P30GM133893), and by the DoE Office of Biological and Environmental Research (KP1607011). This work is based on research performed at the Northeastern Collaborative Access Team beamlines, which are funded by the NIGMS (P30 GM124165). The research used resources of the Advanced Photon Source, a US DoE Office of Science User Facility operated for the DoE Office of Science by Argonne National Laboratory under contract DE-AC02-06CH11357. The Berkeley Center for Structural Biology is supported by the NIH, NIGMS and the Howard Hughes Medical Institute. The Advanced Light Source is supported by the Director, Office of Science, Office of Basic Energy Sciences and US DoE (DE-AC02-05CH11231).","isi":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"department":[{"_id":"FlPr"}],"date_published":"2025-11-13T00:00:00Z","ddc":["570"],"author":[{"first_name":"Adam J.","full_name":"Broerman, Adam J.","last_name":"Broerman"},{"last_name":"Pollmann","full_name":"Pollmann, Christoph","first_name":"Christoph"},{"first_name":"Yang","full_name":"Zhao, Yang","last_name":"Zhao"},{"first_name":"Mauriz A.","full_name":"Lichtenstein, Mauriz A.","last_name":"Lichtenstein"},{"first_name":"Mark D.","full_name":"Jackson, Mark D.","last_name":"Jackson"},{"first_name":"Maxx H.","full_name":"Tessmer, Maxx H.","last_name":"Tessmer"},{"last_name":"Ryu","full_name":"Ryu, Won Hee","first_name":"Won Hee"},{"first_name":"Masato","full_name":"Ogishi, Masato","last_name":"Ogishi"},{"first_name":"Mohamad H.","full_name":"Abedi, Mohamad H.","last_name":"Abedi"},{"last_name":"Sahtoe","full_name":"Sahtoe, Danny D.","first_name":"Danny D."},{"first_name":"Aza","full_name":"Allen, Aza","last_name":"Allen"},{"last_name":"Kang","full_name":"Kang, Alex","first_name":"Alex"},{"full_name":"De La Cruz, Joshmyn","last_name":"De La Cruz","first_name":"Joshmyn"},{"first_name":"Evans","last_name":"Brackenbrough","full_name":"Brackenbrough, Evans"},{"first_name":"Banumathi","full_name":"Sankaran, Banumathi","last_name":"Sankaran"},{"first_name":"Asim K.","full_name":"Bera, Asim K.","last_name":"Bera"},{"full_name":"Zuckerman, Daniel M.","last_name":"Zuckerman","first_name":"Daniel M."},{"full_name":"Stoll, Stefan","last_name":"Stoll","first_name":"Stefan"},{"last_name":"Garcia","full_name":"Garcia, K. Christopher","first_name":"K. Christopher"},{"first_name":"Florian M","orcid":"0000-0002-0806-8101","id":"dfec9381-4341-11ee-8fd8-faa02bba7d62","last_name":"Praetorius","full_name":"Praetorius, Florian M"},{"last_name":"Piehler","full_name":"Piehler, Jacob","first_name":"Jacob"},{"full_name":"Baker, David","last_name":"Baker","first_name":"David"}],"OA_place":"publisher","date_updated":"2026-01-05T13:18:17Z","language":[{"iso":"eng"}],"PlanS_conform":"1","external_id":{"isi":["001577755600001"],"pmid":["40993395"]},"month":"11","oa_version":"Published Version","scopus_import":"1","has_accepted_license":"1","date_created":"2025-10-05T22:01:36Z","year":"2025","quality_controlled":"1","corr_author":"1","article_type":"original","oa":1,"citation":{"apa":"Broerman, A. J., Pollmann, C., Zhao, Y., Lichtenstein, M. A., Jackson, M. D., Tessmer, M. H., … Baker, D. (2025). Design of facilitated dissociation enables timing of cytokine signalling. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-025-09549-z\">https://doi.org/10.1038/s41586-025-09549-z</a>","chicago":"Broerman, Adam J., Christoph Pollmann, Yang Zhao, Mauriz A. Lichtenstein, Mark D. Jackson, Maxx H. Tessmer, Won Hee Ryu, et al. “Design of Facilitated Dissociation Enables Timing of Cytokine Signalling.” <i>Nature</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41586-025-09549-z\">https://doi.org/10.1038/s41586-025-09549-z</a>.","ama":"Broerman AJ, Pollmann C, Zhao Y, et al. Design of facilitated dissociation enables timing of cytokine signalling. <i>Nature</i>. 2025;647:528-535. doi:<a href=\"https://doi.org/10.1038/s41586-025-09549-z\">10.1038/s41586-025-09549-z</a>","ista":"Broerman AJ, Pollmann C, Zhao Y, Lichtenstein MA, Jackson MD, Tessmer MH, Ryu WH, Ogishi M, Abedi MH, Sahtoe DD, Allen A, Kang A, De La Cruz J, Brackenbrough E, Sankaran B, Bera AK, Zuckerman DM, Stoll S, Garcia KC, Praetorius FM, Piehler J, Baker D. 2025. Design of facilitated dissociation enables timing of cytokine signalling. Nature. 647, 528–535.","ieee":"A. J. Broerman <i>et al.</i>, “Design of facilitated dissociation enables timing of cytokine signalling,” <i>Nature</i>, vol. 647. Springer Nature, pp. 528–535, 2025.","mla":"Broerman, Adam J., et al. “Design of Facilitated Dissociation Enables Timing of Cytokine Signalling.” <i>Nature</i>, vol. 647, Springer Nature, 2025, pp. 528–35, doi:<a href=\"https://doi.org/10.1038/s41586-025-09549-z\">10.1038/s41586-025-09549-z</a>.","short":"A.J. Broerman, C. Pollmann, Y. Zhao, M.A. Lichtenstein, M.D. Jackson, M.H. Tessmer, W.H. Ryu, M. Ogishi, M.H. Abedi, D.D. Sahtoe, A. Allen, A. Kang, J. De La Cruz, E. Brackenbrough, B. Sankaran, A.K. Bera, D.M. Zuckerman, S. Stoll, K.C. Garcia, F.M. Praetorius, J. Piehler, D. Baker, Nature 647 (2025) 528–535."},"file_date_updated":"2026-01-05T13:17:47Z","title":"Design of facilitated dissociation enables timing of cytokine signalling","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","file":[{"file_id":"20951","access_level":"open_access","file_size":22099921,"checksum":"b4ec44134e2eb320a724dc29158dfda2","success":1,"creator":"dernst","date_updated":"2026-01-05T13:17:47Z","relation":"main_file","content_type":"application/pdf","date_created":"2026-01-05T13:17:47Z","file_name":"2025_Nature_Broerman.pdf"}],"abstract":[{"lang":"eng","text":"Protein design has focused on the design of ground states, ensuring that they are sufficiently low energy to be highly populated1. Designing the kinetics and dynamics of a system requires, in addition, the design of excited states that are traversed in transitions from one low-lying state to another2,3. This is a challenging task because such states must be sufficiently strained to be poorly populated, but not so strained that they are not populated at all, and because protein design methods have focused on generating near-ideal structures4,5,6,7. Here we describe a general approach for designing systems that use an induced-fit power stroke8 to generate a structurally frustrated9 and strained excited state, allosterically driving protein complex dissociation. X-ray crystallography, double electron–electron resonance spectroscopy and kinetic binding measurements show that incorporating excited states enables the design of effector-induced increases in dissociation rates as high as 5,700-fold. We highlight the power of this approach by designing rapid biosensors, kinetically controlled circuits and cytokine mimics that can be dissociated from their receptors within seconds, enabling dissection of the temporal dynamics of interleukin-2 signalling."}],"_id":"20430","pmid":1,"intvolume":"       647","status":"public","publication":"Nature","publisher":"Springer Nature","OA_type":"hybrid","article_processing_charge":"Yes (in subscription journal)","type":"journal_article","volume":647,"page":"528-535","day":"13"},{"department":[{"_id":"GaNo"}],"isi":1,"publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"acknowledgement":"The authors thank members of their laboratories who provided feedback on earlier versions of this manuscript, including A. Jourdon, V. Mariano, T. L. Li, N. Caporale, E. Villa and M. Sutcliffe.","doi":"10.1038/s41586-024-08487-6","month":"03","scopus_import":"1","oa_version":"None","language":[{"iso":"eng"}],"external_id":{"isi":["001437461900001"],"pmid":["39653126"]},"date_updated":"2025-09-30T11:13:47Z","date_published":"2025-03-13T00:00:00Z","author":[{"first_name":"Sergiu P.","full_name":"Pașca, Sergiu P.","last_name":"Pașca"},{"first_name":"Paola","full_name":"Arlotta, Paola","last_name":"Arlotta"},{"full_name":"Bateup, Helen S.","last_name":"Bateup","first_name":"Helen S."},{"last_name":"Camp","full_name":"Camp, J. Gray","first_name":"J. Gray"},{"first_name":"Silvia","last_name":"Cappello","full_name":"Cappello, Silvia"},{"first_name":"Fred H.","full_name":"Gage, Fred H.","last_name":"Gage"},{"first_name":"Jürgen A.","last_name":"Knoblich","full_name":"Knoblich, Jürgen A."},{"first_name":"Arnold R.","full_name":"Kriegstein, Arnold R.","last_name":"Kriegstein"},{"first_name":"Madeline A.","full_name":"Lancaster, Madeline A.","last_name":"Lancaster"},{"full_name":"Ming, Guo Li","last_name":"Ming","first_name":"Guo Li"},{"last_name":"Novarino","full_name":"Novarino, Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","first_name":"Gaia","orcid":"0000-0002-7673-7178"},{"last_name":"Okano","full_name":"Okano, Hideyuki","first_name":"Hideyuki"},{"first_name":"Malin","full_name":"Parmar, Malin","last_name":"Parmar"},{"last_name":"Park","full_name":"Park, In Hyun","first_name":"In Hyun"},{"first_name":"Orly","last_name":"Reiner","full_name":"Reiner, Orly"},{"first_name":"Hongjun","last_name":"Song","full_name":"Song, Hongjun"},{"last_name":"Studer","full_name":"Studer, Lorenz","first_name":"Lorenz"},{"last_name":"Takahashi","full_name":"Takahashi, Jun","first_name":"Jun"},{"first_name":"Sally","full_name":"Temple, Sally","last_name":"Temple"},{"first_name":"Giuseppe","last_name":"Testa","full_name":"Testa, Giuseppe"},{"first_name":"Barbara","full_name":"Treutlein, Barbara","last_name":"Treutlein"},{"full_name":"Vaccarino, Flora M.","last_name":"Vaccarino","first_name":"Flora M."},{"first_name":"Pierre","last_name":"Vanderhaeghen","full_name":"Vanderhaeghen, Pierre"},{"last_name":"Young-Pearse","full_name":"Young-Pearse, Tracy","first_name":"Tracy"}],"title":"A framework for neural organoids, assembloids and transplantation studies","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","citation":{"ieee":"S. P. Pașca <i>et al.</i>, “A framework for neural organoids, assembloids and transplantation studies,” <i>Nature</i>, vol. 639, no. 8054. Springer Nature, pp. 315–320, 2025.","short":"S.P. Pașca, P. Arlotta, H.S. Bateup, J.G. Camp, S. Cappello, F.H. Gage, J.A. Knoblich, A.R. Kriegstein, M.A. Lancaster, G.L. Ming, G. Novarino, H. Okano, M. Parmar, I.H. Park, O. Reiner, H. Song, L. Studer, J. Takahashi, S. Temple, G. Testa, B. Treutlein, F.M. Vaccarino, P. Vanderhaeghen, T. Young-Pearse, Nature 639 (2025) 315–320.","mla":"Pașca, Sergiu P., et al. “A Framework for Neural Organoids, Assembloids and Transplantation Studies.” <i>Nature</i>, vol. 639, no. 8054, Springer Nature, 2025, pp. 315–20, doi:<a href=\"https://doi.org/10.1038/s41586-024-08487-6\">10.1038/s41586-024-08487-6</a>.","chicago":"Pașca, Sergiu P., Paola Arlotta, Helen S. Bateup, J. Gray Camp, Silvia Cappello, Fred H. Gage, Jürgen A. Knoblich, et al. “A Framework for Neural Organoids, Assembloids and Transplantation Studies.” <i>Nature</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41586-024-08487-6\">https://doi.org/10.1038/s41586-024-08487-6</a>.","apa":"Pașca, S. P., Arlotta, P., Bateup, H. S., Camp, J. G., Cappello, S., Gage, F. H., … Young-Pearse, T. (2025). A framework for neural organoids, assembloids and transplantation studies. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-024-08487-6\">https://doi.org/10.1038/s41586-024-08487-6</a>","ista":"Pașca SP, Arlotta P, Bateup HS, Camp JG, Cappello S, Gage FH, Knoblich JA, Kriegstein AR, Lancaster MA, Ming GL, Novarino G, Okano H, Parmar M, Park IH, Reiner O, Song H, Studer L, Takahashi J, Temple S, Testa G, Treutlein B, Vaccarino FM, Vanderhaeghen P, Young-Pearse T. 2025. A framework for neural organoids, assembloids and transplantation studies. Nature. 639(8054), 315–320.","ama":"Pașca SP, Arlotta P, Bateup HS, et al. A framework for neural organoids, assembloids and transplantation studies. <i>Nature</i>. 2025;639(8054):315-320. doi:<a href=\"https://doi.org/10.1038/s41586-024-08487-6\">10.1038/s41586-024-08487-6</a>"},"date_created":"2025-03-23T23:01:27Z","year":"2025","quality_controlled":"1","article_type":"original","type":"journal_article","volume":639,"day":"13","page":"315-320","publication":"Nature","issue":"8054","publisher":"Springer Nature","OA_type":"closed access","article_processing_charge":"No","pmid":1,"_id":"19444","abstract":[{"lang":"eng","text":"As the field of neural organoids and assembloids expands, there is an emergent need for guidance and advice on designing, conducting and reporting experiments to increase the reproducibility and utility of these models. In this Perspective, we present a framework for the experimental process that encompasses ensuring the quality and integrity of human pluripotent stem cells, characterizing and manipulating neural cells in vitro, transplantation techniques and considerations for modelling human development, evolution and disease. As with all scientific endeavours, we advocate for rigorous experimental designs tailored to explicit scientific questions as well as transparent methodologies and data sharing to provide useful knowledge for current research practices and for developing regulatory standards."}],"intvolume":"       639","status":"public","publication_status":"published"},{"external_id":{"isi":["001483477000001"],"pmid":["40335689"]},"PlanS_conform":"1","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"ScienComp"},{"_id":"PreCl"},{"_id":"M-Shop"},{"_id":"E-Lib"}],"language":[{"iso":"eng"}],"has_accepted_license":"1","scopus_import":"1","oa_version":"Published Version","month":"06","author":[{"first_name":"Mojtaba","orcid":"0000-0002-7667-6854","full_name":"Tavakoli, Mojtaba","id":"3A0A06F4-F248-11E8-B48F-1D18A9856A87","last_name":"Tavakoli"},{"first_name":"Julia","full_name":"Lyudchik, Julia","last_name":"Lyudchik","id":"46E28B80-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Januszewski, Michał","last_name":"Januszewski","first_name":"Michał"},{"first_name":"Vitali","full_name":"Vistunou, Vitali","last_name":"Vistunou","id":"7e146587-8972-11ed-ae7b-d7a32ea86a81"},{"last_name":"Agudelo Duenas","full_name":"Agudelo Duenas, Nathalie","id":"40E7F008-F248-11E8-B48F-1D18A9856A87","first_name":"Nathalie"},{"last_name":"Vorlaufer","full_name":"Vorlaufer, Jakob","id":"937696FA-C996-11E9-8C7C-CF13E6697425","first_name":"Jakob","orcid":"0009-0000-7590-3501"},{"full_name":"Sommer, Christoph M","last_name":"Sommer","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1216-9105","first_name":"Christoph M"},{"id":"382077BA-F248-11E8-B48F-1D18A9856A87","last_name":"Kreuzinger","full_name":"Kreuzinger, Caroline","first_name":"Caroline"},{"last_name":"Oliveira","full_name":"Oliveira, Bárbara","id":"3B03AA1A-F248-11E8-B48F-1D18A9856A87","first_name":"Bárbara"},{"last_name":"Cenameri","full_name":"Cenameri, Alban","id":"9ac8f577-2357-11eb-997a-e566c5550886","first_name":"Alban"},{"id":"3E57A680-F248-11E8-B48F-1D18A9856A87","full_name":"Novarino, Gaia","last_name":"Novarino","first_name":"Gaia","orcid":"0000-0002-7673-7178"},{"first_name":"Viren","last_name":"Jain","full_name":"Jain, Viren"},{"full_name":"Danzl, Johann G","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","last_name":"Danzl","first_name":"Johann G","orcid":"0000-0001-8559-3973"}],"ddc":["570"],"date_published":"2025-06-12T00:00:00Z","date_updated":"2026-01-05T14:11:56Z","project":[{"grant_number":"26137","name":"Studying Organelle Structure and Function at Nanoscale Resolution with Expansion Microscopy","_id":"6285a163-2b32-11ec-9570-8e204ca2dba5"},{"name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"665385"},{"grant_number":"101044865","name":"Toward an understanding of the brain interstitial system and the extracellular proteome in health and autism spectrum disorders","_id":"34ba8964-11ca-11ed-8bc3-e15864e7e9a6"},{"grant_number":"W1232-B24","name":"Molecular Drug Targets","_id":"26AA4EF2-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"OA_place":"publisher","isi":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"department":[{"_id":"JoDa"},{"_id":"GradSch"},{"_id":"Bio"},{"_id":"GaNo"}],"doi":"10.1038/s41586-025-08985-1","acknowledgement":"We thank S. Dorkenwald and P. Li for critical reading of the manuscript, S. Loomba for discussions and E. Miguel for support with data handling. We acknowledge support from ISTA’s scientific service units: Imaging and Optics, Lab Support, Scientific Computing, the preclinical facility, the Miba Machine Shop and the library. We acknowledge funding from the following sources: Austrian Science Fund (FWF) grant DK W1232 (J.G.D. and M.R.T.); Austrian Academy of Sciences DOC fellowship 26137 (M.R.T.); Gesellschaft für Forschungsförderung NÖ (NFB) grant LSC18-022 (J.G.D.); the European Union’s Horizon 2020 research and innovation programme and Marie Skłodowska-Curie Actions Fellowship 665385 (J.L.); and the European Union’s Horizon 2020 research and innovation programme and European Research Council (ERC) grant 101044865 ‘SecretAutism’ (G.N.).Open access funding provided by Institute of Science and Technology (IST Austria).","publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"article_processing_charge":"Yes (via OA deal)","OA_type":"hybrid","publisher":"Springer Nature","publication":"Nature","day":"12","page":"398-410","volume":642,"type":"journal_article","file":[{"success":1,"creator":"dernst","date_updated":"2025-07-03T06:55:20Z","content_type":"application/pdf","relation":"main_file","file_name":"2025_Nature_Tavakoli.pdf","date_created":"2025-07-03T06:55:20Z","file_id":"19959","access_level":"open_access","file_size":133201290,"checksum":"ebc99d7108e728f46db0a009292675ef"}],"publication_status":"published","status":"public","pmid":1,"_id":"19704","intvolume":"       642","abstract":[{"lang":"eng","text":"The information-processing capability of the brain’s cellular network depends on the physical wiring pattern between neurons and their molecular and functional characteristics. Mapping neurons and resolving their individual synaptic connections can be achieved by volumetric imaging at nanoscale resolution1,2 with dense cellular labelling. Light microscopy is uniquely positioned to visualize specific molecules, but dense, synapse-level circuit reconstruction by light microscopy has been out of reach, owing to limitations in resolution, contrast and volumetric imaging capability. Here we describe light-microscopy-based connectomics (LICONN). We integrated specifically engineered hydrogel embedding and expansion with comprehensive deep-learning-based segmentation and analysis of connectivity, thereby directly incorporating molecular information into synapse-level reconstructions of brain tissue. LICONN will allow synapse-level phenotyping of brain tissue in biological experiments in a readily adoptable manner."}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","related_material":{"record":[{"status":"public","id":"18677","relation":"earlier_version"},{"id":"18697","relation":"research_data","status":"public"}]},"ec_funded":1,"title":"Light-microscopy-based connectomic reconstruction of mammalian brain tissue","file_date_updated":"2025-07-03T06:55:20Z","article_type":"original","corr_author":"1","quality_controlled":"1","year":"2025","date_created":"2025-05-18T22:02:51Z","citation":{"apa":"Tavakoli, M., Lyudchik, J., Januszewski, M., Vistunou, V., Agudelo Duenas, N., Vorlaufer, J., … Danzl, J. G. (2025). Light-microscopy-based connectomic reconstruction of mammalian brain tissue. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-025-08985-1\">https://doi.org/10.1038/s41586-025-08985-1</a>","chicago":"Tavakoli, Mojtaba, Julia Lyudchik, Michał Januszewski, Vitali Vistunou, Nathalie Agudelo Duenas, Jakob Vorlaufer, Christoph M Sommer, et al. “Light-Microscopy-Based Connectomic Reconstruction of Mammalian Brain Tissue.” <i>Nature</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41586-025-08985-1\">https://doi.org/10.1038/s41586-025-08985-1</a>.","ama":"Tavakoli M, Lyudchik J, Januszewski M, et al. Light-microscopy-based connectomic reconstruction of mammalian brain tissue. <i>Nature</i>. 2025;642:398-410. doi:<a href=\"https://doi.org/10.1038/s41586-025-08985-1\">10.1038/s41586-025-08985-1</a>","ista":"Tavakoli M, Lyudchik J, Januszewski M, Vistunou V, Agudelo Duenas N, Vorlaufer J, Sommer CM, Kreuzinger C, Oliveira B, Cenameri A, Novarino G, Jain V, Danzl JG. 2025. Light-microscopy-based connectomic reconstruction of mammalian brain tissue. Nature. 642, 398–410.","short":"M. Tavakoli, J. Lyudchik, M. Januszewski, V. Vistunou, N. Agudelo Duenas, J. Vorlaufer, C.M. Sommer, C. Kreuzinger, B. Oliveira, A. Cenameri, G. Novarino, V. Jain, J.G. Danzl, Nature 642 (2025) 398–410.","ieee":"M. Tavakoli <i>et al.</i>, “Light-microscopy-based connectomic reconstruction of mammalian brain tissue,” <i>Nature</i>, vol. 642. Springer Nature, pp. 398–410, 2025.","mla":"Tavakoli, Mojtaba, et al. “Light-Microscopy-Based Connectomic Reconstruction of Mammalian Brain Tissue.” <i>Nature</i>, vol. 642, Springer Nature, 2025, pp. 398–410, doi:<a href=\"https://doi.org/10.1038/s41586-025-08985-1\">10.1038/s41586-025-08985-1</a>."},"oa":1},{"author":[{"first_name":"Soumyadip","id":"d25d21ef-dc8d-11ea-abe3-ec4576307f48","full_name":"Mondal, Soumyadip","last_name":"Mondal"},{"last_name":"Nguyen","full_name":"Nguyen, Huyen T.K.","first_name":"Huyen T.K."},{"full_name":"Hauschild, Robert","last_name":"Hauschild","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","orcid":"0000-0001-9843-3522"},{"last_name":"Freunberger","full_name":"Freunberger, Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","first_name":"Stefan Alexander","orcid":"0000-0003-2902-5319"}],"date_published":"2025-10-16T00:00:00Z","ddc":["540"],"OA_place":"publisher","date_updated":"2025-11-27T13:20:38Z","project":[{"name":"Singlet oxygen in non-aqueous oxygen redox chemistry","_id":"8df062be-16d5-11f0-9cad-f559b6612c7e","grant_number":"P37169"},{"name":"Tools for automation and feedback microscopy","_id":"c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473","grant_number":"CZI01"}],"PlanS_conform":"1","external_id":{"pmid":["41044415"],"isi":["001586378900001"]},"language":[{"iso":"eng"}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"M-Shop"},{"_id":"ScienComp"}],"scopus_import":"1","oa_version":"Published Version","has_accepted_license":"1","month":"10","doi":"10.1038/s41586-025-09587-7","acknowledgement":"S.A.F. thanks the Institute of Science and Technology Austria (ISTA) for the support. The Scientific Service Units of ISTA supported this research through resources provided by the Imaging and Optics Facility, the Lab Support Facility, the Miba Machine Shop and Scientific Computing. This research was partly funded by the Austrian Science Fund (FWF) (10.55776/P37169 and 10.55776/COE5). For open access purposes, the author has applied for a CC BY public copyright licence to any author-accepted manuscript version arising from this submission. R.H. acknowledges funding through CZI grant DAF2020-225401 (10.37921/120055ratwvi) from the Chan Zuckerberg Initiative DAF, an advised fund of Silicon Valley Community Foundation (10.13039/100014989). H.T.K.N. acknowledges funding by the European Commission Erasmus Mundus Joint Masters programme. We thank M. Sixt and M. Chinon for the discussions about O-redox in life and R. Jethwa for proofreading. Open access funding was provided by ISTA.","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"department":[{"_id":"StFr"},{"_id":"Bio"}],"isi":1,"publication_status":"published","file":[{"checksum":"b507ddd23df0388aa65d04dc9b00fe3d","file_size":3809247,"access_level":"open_access","file_id":"20500","date_created":"2025-10-20T10:26:13Z","file_name":"2025_Nature_Mondal.pdf","relation":"main_file","content_type":"application/pdf","date_updated":"2025-10-20T10:26:13Z","creator":"dernst","success":1}],"pmid":1,"_id":"17468","abstract":[{"text":"Oxygen redox chemistry is central to life1 and many human-made technologies, such as in energy storage2,3,4. The large energy gain from oxygen redox reactions is often connected with the occurrence of harmful reactive oxygen species3,5,6. Key species are superoxide and the highly reactive singlet oxygen3,4,5,6,7, which may evolve from superoxide. However, the factors determining the formation of singlet oxygen, rather than the relatively unreactive triplet oxygen, are unknown. Here we report that the release of triplet or singlet oxygen is governed by individual Marcus normal and inverted region behaviour. We found that as the driving force for the reaction increases, the initially dominant evolution of triplet oxygen slows down, and singlet oxygen evolution becomes predominant with higher maximum kinetics. This behaviour also applies to the widely observed superoxide disproportionation, in which one superoxide is oxidized by another, in both non-aqueous and aqueous systems, with Lewis and Brønsted acidity controlling the driving forces. Singlet oxygen yields governed by these conditions are relevant, for example, in batteries or cellular organelles in which superoxide forms. Our findings suggest ways to understand and control spin states and kinetics in oxygen redox chemistry, with implications for fields, including life sciences, pure chemistry and energy storage.","lang":"eng"}],"intvolume":"       646","status":"public","OA_type":"hybrid","article_processing_charge":"Yes (via OA deal)","issue":"8085","publication":"Nature","publisher":"Springer Nature","volume":646,"day":"16","page":"601–605","type":"journal_article","corr_author":"1","quality_controlled":"1","article_type":"original","date_created":"2024-08-29T10:40:23Z","year":"2025","citation":{"apa":"Mondal, S., Nguyen, H. T. K., Hauschild, R., &#38; Freunberger, S. A. (2025). Marcus kinetics control singlet and triplet oxygen evolving from superoxide. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-025-09587-7\">https://doi.org/10.1038/s41586-025-09587-7</a>","chicago":"Mondal, Soumyadip, Huyen T.K. Nguyen, Robert Hauschild, and Stefan Alexander Freunberger. “Marcus Kinetics Control Singlet and Triplet Oxygen Evolving from Superoxide.” <i>Nature</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41586-025-09587-7\">https://doi.org/10.1038/s41586-025-09587-7</a>.","ama":"Mondal S, Nguyen HTK, Hauschild R, Freunberger SA. Marcus kinetics control singlet and triplet oxygen evolving from superoxide. <i>Nature</i>. 2025;646(8085):601–605. doi:<a href=\"https://doi.org/10.1038/s41586-025-09587-7\">10.1038/s41586-025-09587-7</a>","ista":"Mondal S, Nguyen HTK, Hauschild R, Freunberger SA. 2025. Marcus kinetics control singlet and triplet oxygen evolving from superoxide. Nature. 646(8085), 601–605.","short":"S. Mondal, H.T.K. Nguyen, R. Hauschild, S.A. Freunberger, Nature 646 (2025) 601–605.","mla":"Mondal, Soumyadip, et al. “Marcus Kinetics Control Singlet and Triplet Oxygen Evolving from Superoxide.” <i>Nature</i>, vol. 646, no. 8085, Springer Nature, 2025, pp. 601–605, doi:<a href=\"https://doi.org/10.1038/s41586-025-09587-7\">10.1038/s41586-025-09587-7</a>.","ieee":"S. Mondal, H. T. K. Nguyen, R. Hauschild, and S. A. Freunberger, “Marcus kinetics control singlet and triplet oxygen evolving from superoxide,” <i>Nature</i>, vol. 646, no. 8085. Springer Nature, pp. 601–605, 2025."},"oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2025-10-20T10:26:13Z","title":"Marcus kinetics control singlet and triplet oxygen evolving from superoxide"},{"file":[{"file_size":3807415,"checksum":"fecf302274dd3218d3e7dd22f39a6c0c","access_level":"open_access","file_id":"19289","file_name":"2025_Nature_Sobarzo.pdf","date_created":"2025-03-04T10:05:18Z","content_type":"application/pdf","relation":"main_file","date_updated":"2025-03-04T10:05:18Z","creator":"dernst","success":1}],"publication_status":"published","status":"public","abstract":[{"text":"When two insulating, neutral materials are contacted and separated, they exchange electrical charge1. Experiments have long suggested that this ‘contact electrification’ is transitive, with different materials ordering into ‘triboelectric series’ based on the sign of charge acquired2. At the same time, the effect is plagued by unpredictability, preventing consensus on the mechanism and casting doubt on the rhyme and reason that series imply3. Here we expose an unanticipated connection between the unpredictability and order in contact electrification: nominally identical materials initially exchange charge randomly and intransitively, but—over repeated experiments—order into triboelectric series. We find that this evolution is driven by the act of contact itself—samples with more contacts in their history charge negatively to ones with fewer contacts. Capturing this ‘contact bias’ in a minimal model, we recreate both the initial randomness and ultimate order in numerical simulations and use it experimentally to force the appearance of a triboelectric series of our choosing. With a set of surface-sensitive techniques to search for the underlying alterations contact creates, we only find evidence of nanoscale morphological changes, pointing to a mechanism strongly coupled with mechanics. Our results highlight the centrality of contact history in contact electrification and suggest that focusing on the unpredictability that has long plagued the effect may hold the key to understanding it.","lang":"eng"}],"_id":"19278","intvolume":"       638","pmid":1,"article_processing_charge":"Yes (via OA deal)","OA_type":"hybrid","publisher":"Springer Nature","issue":"8051","publication":"Nature","day":"20","volume":638,"type":"journal_article","article_type":"original","corr_author":"1","quality_controlled":"1","year":"2025","date_created":"2025-03-02T23:01:52Z","citation":{"short":"J.C.A. Sobarzo Ponce, F. Pertl, D. Balazs, T. Costanzo, M. Sauer, A. Foelske, M. Ostermann, C.M. Pichler, Y. Wang, Y. Nagata, M. Bonn, S.R. Waitukaitis, Nature 638 (2025).","mla":"Sobarzo Ponce, Juan Carlos A., et al. “Spontaneous Ordering of Identical Materials into a Triboelectric Series.” <i>Nature</i>, vol. 638, no. 8051, 664–669, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41586-024-08530-6\">10.1038/s41586-024-08530-6</a>.","ieee":"J. C. A. Sobarzo Ponce <i>et al.</i>, “Spontaneous ordering of identical materials into a triboelectric series,” <i>Nature</i>, vol. 638, no. 8051. Springer Nature, 2025.","apa":"Sobarzo Ponce, J. C. A., Pertl, F., Balazs, D., Costanzo, T., Sauer, M., Foelske, A., … Waitukaitis, S. R. (2025). Spontaneous ordering of identical materials into a triboelectric series. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-024-08530-6\">https://doi.org/10.1038/s41586-024-08530-6</a>","chicago":"Sobarzo Ponce, Juan Carlos A, Felix Pertl, Daniel Balazs, Tommaso Costanzo, Markus Sauer, Annette Foelske, Markus Ostermann, et al. “Spontaneous Ordering of Identical Materials into a Triboelectric Series.” <i>Nature</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41586-024-08530-6\">https://doi.org/10.1038/s41586-024-08530-6</a>.","ama":"Sobarzo Ponce JCA, Pertl F, Balazs D, et al. Spontaneous ordering of identical materials into a triboelectric series. <i>Nature</i>. 2025;638(8051). doi:<a href=\"https://doi.org/10.1038/s41586-024-08530-6\">10.1038/s41586-024-08530-6</a>","ista":"Sobarzo Ponce JCA, Pertl F, Balazs D, Costanzo T, Sauer M, Foelske A, Ostermann M, Pichler CM, Wang Y, Nagata Y, Bonn M, Waitukaitis SR. 2025. Spontaneous ordering of identical materials into a triboelectric series. Nature. 638(8051), 664–669."},"oa":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"20203"}]},"title":"Spontaneous ordering of identical materials into a triboelectric series","ec_funded":1,"file_date_updated":"2025-03-04T10:05:18Z","author":[{"id":"4B807D68-AE37-11E9-AC72-31CAE5697425","last_name":"Sobarzo Ponce","full_name":"Sobarzo Ponce, Juan Carlos A","first_name":"Juan Carlos A"},{"last_name":"Pertl","id":"6313aec0-15b2-11ec-abd3-ed67d16139af","full_name":"Pertl, Felix","orcid":"0000-0003-0463-5794","first_name":"Felix"},{"last_name":"Balazs","id":"302BADF6-85FC-11EA-9E3B-B9493DDC885E","full_name":"Balazs, Daniel","orcid":"0000-0001-7597-043X","first_name":"Daniel"},{"full_name":"Costanzo, Tommaso","id":"D93824F4-D9BA-11E9-BB12-F207E6697425","last_name":"Costanzo","first_name":"Tommaso","orcid":"0000-0001-9732-3815"},{"first_name":"Markus","full_name":"Sauer, Markus","last_name":"Sauer"},{"first_name":"Annette","last_name":"Foelske","full_name":"Foelske, Annette"},{"full_name":"Ostermann, Markus","last_name":"Ostermann","first_name":"Markus"},{"full_name":"Pichler, Christian M.","last_name":"Pichler","first_name":"Christian M."},{"first_name":"Yongkang","last_name":"Wang","full_name":"Wang, Yongkang"},{"first_name":"Yuki","full_name":"Nagata, Yuki","last_name":"Nagata"},{"first_name":"Mischa","last_name":"Bonn","full_name":"Bonn, Mischa"},{"first_name":"Scott R","orcid":"0000-0002-2299-3176","last_name":"Waitukaitis","full_name":"Waitukaitis, Scott R","id":"3A1FFC16-F248-11E8-B48F-1D18A9856A87"}],"ddc":["530"],"date_published":"2025-02-20T00:00:00Z","project":[{"grant_number":"949120","_id":"0aa60e99-070f-11eb-9043-a6de6bdc3afa","call_identifier":"H2020","name":"Tribocharge: a multi-scale approach to an enduring problem in physics"}],"date_updated":"2026-04-07T11:50:54Z","OA_place":"publisher","external_id":{"pmid":["39972227"],"isi":["001428076100015"]},"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"},{"_id":"ScienComp"},{"_id":"EM-Fac"},{"_id":"LifeSc"}],"language":[{"iso":"eng"}],"has_accepted_license":"1","oa_version":"Published Version","scopus_import":"1","month":"02","doi":"10.1038/s41586-024-08530-6","acknowledgement":"This project has received financing from the European Research Council grant agreement no. 949120 under the European Union’s Horizon 2020 research and innovation programme. The Analytical Instrumentation Center of the TU Wien acknowledges support by the FFG project ‘ELSA’ under grant no. 884672. C.M.P. and M.O. acknowledge the state of Lower Austria and the European Regional Development Fund under grant no. WST3-F-542638/004-2021. This research was supported by the Scientific Service Units of the Institute of Science and Technology Austria through resources provided by the Miba Machine Shop, Nanofabrication Facility, Scientific Computing facility, Electron Microscopy Facility and Lab Support Facility. We thank J. Garcia-Suarez and G. Anciaux for the suggestion to look into the roughness power spectral density. We thank I.-M. Strugaru for help with testing the device for Young’s modulus measurements. Open access funding provided by Institute of Science and Technology (IST Austria).","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"article_number":"664-669","department":[{"_id":"ScWa"},{"_id":"LifeSc"},{"_id":"EM-Fac"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"isi":1},{"publisher":"Springer Nature","publication":"Nature","article_processing_charge":"Yes (via OA deal)","OA_type":"hybrid","type":"journal_article","day":"24","page":"1011-1016","volume":640,"file":[{"checksum":"f5f18081003e7a1b8e372ecb7da82e7d","file_size":13549245,"access_level":"open_access","file_id":"20132","file_name":"2025_Nature_Chen.pdf","date_created":"2025-08-05T12:29:35Z","content_type":"application/pdf","relation":"main_file","date_updated":"2025-08-05T12:29:35Z","creator":"dernst","success":1}],"publication_status":"published","status":"public","_id":"19421","abstract":[{"lang":"eng","text":"The phytohormone auxin (Aux) is a principal endogenous developmental signal in plants. It mediates transcriptional reprogramming by a well-established canonical signalling mechanism. TIR1/AFB auxin receptors are F-box subunits of an ubiquitin ligase complex; after auxin perception, they associate with Aux/IAA transcriptional repressors and ubiquitinate them for degradation, thus enabling the activation of auxin response factor (ARF) transcription factors1,2,3. Here we revise this paradigm by showing that without TIR1 adenylate cyclase (AC) activity4, auxin-induced degradation of Aux/IAAs is not sufficient to mediate the transcriptional auxin response. Abolishing the TIR1 AC activity does not affect auxin-induced degradation of Aux/IAAs but renders TIR1 non-functional in mediating transcriptional reprogramming and auxin-regulated development, including shoot, root, root hair growth and lateral root formation. Transgenic plants show that local cAMP production in the vicinity of the Aux/IAA–ARF complex by unrelated AC enzymes bypasses the need for auxin perception and is sufficient to induce ARF-mediated transcription. These discoveries revise the canonical model of auxin signalling and establish TIR1/AFB-produced cAMP as a second messenger essential for transcriptional reprograming."}],"pmid":1,"intvolume":"       640","title":"TIR1-produced cAMP as a second messenger in transcriptional auxin signalling","file_date_updated":"2025-08-05T12:29:35Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","related_material":{"record":[{"status":"public","id":"19478","relation":"dissertation_contains"}]},"year":"2025","date_created":"2025-03-19T09:44:39Z","article_type":"original","corr_author":"1","quality_controlled":"1","oa":1,"citation":{"chicago":"Chen, Huihuang, Linlin Qi, Minxia Zou, Mengting Lu, M Kwiatkowski, Yuanrong Pei, K Jaworski, and Jiří Friml. “TIR1-Produced CAMP as a Second Messenger in Transcriptional Auxin Signalling.” <i>Nature</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41586-025-08669-w\">https://doi.org/10.1038/s41586-025-08669-w</a>.","apa":"Chen, H., Qi, L., Zou, M., Lu, M., Kwiatkowski, M., Pei, Y., … Friml, J. (2025). TIR1-produced cAMP as a second messenger in transcriptional auxin signalling. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-025-08669-w\">https://doi.org/10.1038/s41586-025-08669-w</a>","ista":"Chen H, Qi L, Zou M, Lu M, Kwiatkowski M, Pei Y, Jaworski K, Friml J. 2025. TIR1-produced cAMP as a second messenger in transcriptional auxin signalling. Nature. 640, 1011–1016.","ama":"Chen H, Qi L, Zou M, et al. TIR1-produced cAMP as a second messenger in transcriptional auxin signalling. <i>Nature</i>. 2025;640:1011-1016. doi:<a href=\"https://doi.org/10.1038/s41586-025-08669-w\">10.1038/s41586-025-08669-w</a>","short":"H. Chen, L. Qi, M. Zou, M. Lu, M. Kwiatkowski, Y. Pei, K. Jaworski, J. Friml, Nature 640 (2025) 1011–1016.","mla":"Chen, Huihuang, et al. “TIR1-Produced CAMP as a Second Messenger in Transcriptional Auxin Signalling.” <i>Nature</i>, vol. 640, Springer Nature, 2025, pp. 1011–16, doi:<a href=\"https://doi.org/10.1038/s41586-025-08669-w\">10.1038/s41586-025-08669-w</a>.","ieee":"H. Chen <i>et al.</i>, “TIR1-produced cAMP as a second messenger in transcriptional auxin signalling,” <i>Nature</i>, vol. 640. Springer Nature, pp. 1011–1016, 2025."},"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"}],"language":[{"iso":"eng"}],"external_id":{"pmid":["40044868"],"isi":["001437493900001"]},"PlanS_conform":"1","month":"04","has_accepted_license":"1","oa_version":"Published Version","ddc":["580"],"date_published":"2025-04-24T00:00:00Z","author":[{"first_name":"Huihuang","id":"83c96512-15b2-11ec-abd3-b7eede36184f","last_name":"Chen","full_name":"Chen, Huihuang"},{"id":"44B04502-A9ED-11E9-B6FC-583AE6697425","full_name":"Qi, Linlin","last_name":"Qi","first_name":"Linlin","orcid":"0000-0001-5187-8401"},{"first_name":"Minxia","last_name":"Zou","full_name":"Zou, Minxia","id":"5c243f41-03f3-11ec-841c-96faf48a7ef9"},{"first_name":"Mengting","last_name":"Lu","full_name":"Lu, Mengting","id":"a8198a14-1ffe-11ee-8b67-d2bdff9d9178"},{"last_name":"Kwiatkowski","full_name":"Kwiatkowski, M","first_name":"M"},{"first_name":"Yuanrong","last_name":"Pei","full_name":"Pei, Yuanrong","id":"98605edc-6ce7-11ee-95f3-cc16b866efcd"},{"first_name":"K","full_name":"Jaworski, K","last_name":"Jaworski"},{"first_name":"Jiří","orcid":"0000-0002-8302-7596","last_name":"Friml","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"date_updated":"2026-04-07T11:51:24Z","project":[{"_id":"7bcece63-9f16-11ee-852c-ae94e099eeb6","name":"Guanylate cyclase activity of TIR1/AFBs auxin receptors","grant_number":"P37051"}],"OA_place":"publisher","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"isi":1,"department":[{"_id":"JiFr"}],"doi":"10.1038/s41586-025-08669-w","publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"acknowledgement":"We are grateful to J. Callis and H.-Q. Yang for sharing materials and to M. Estelle and S. Kepinski for inspiring discussions. This research was supported by the Laboratory Support Facility, the Plant Facility and the Imaging and Optics Facility of the Institute of Science and Technology Austria. This project has received funding from the European Research Council (101142681 CYNIPS) and Austrian Science Fund (P 37051-B). L.Q. was supported by the National Natural Science Foundation of China (grant no. 32470327). M.Z. was supported by the Interdisciplinary Project Committee of the Institute of Science and Technology Austria, and Y.P. was supported by an EMBO Postdoctoral Fellowship (ALTF 38-2023). Open access funding provided by Institute of Science and Technology (IST Austria)."},{"title":"Non-Abelian lattice gauge fields in photonic synthetic frequency dimensions","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2025","date_created":"2026-03-30T12:22:47Z","article_type":"original","quality_controlled":"1","oa":1,"citation":{"ista":"Cheng D, Wang K, Roques-Carmes C, Lustig E, Long OY, Wang H, Fan S. 2025. Non-Abelian lattice gauge fields in photonic synthetic frequency dimensions. Nature. 637(8044), 52–56.","ama":"Cheng D, Wang K, Roques-Carmes C, et al. Non-Abelian lattice gauge fields in photonic synthetic frequency dimensions. <i>Nature</i>. 2025;637(8044):52-56. doi:<a href=\"https://doi.org/10.1038/s41586-024-08259-2\">10.1038/s41586-024-08259-2</a>","chicago":"Cheng, Dali, Kai Wang, Charles Roques-Carmes, Eran Lustig, Olivia Y. Long, Heming Wang, and Shanhui Fan. “Non-Abelian Lattice Gauge Fields in Photonic Synthetic Frequency Dimensions.” <i>Nature</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41586-024-08259-2\">https://doi.org/10.1038/s41586-024-08259-2</a>.","apa":"Cheng, D., Wang, K., Roques-Carmes, C., Lustig, E., Long, O. Y., Wang, H., &#38; Fan, S. (2025). Non-Abelian lattice gauge fields in photonic synthetic frequency dimensions. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-024-08259-2\">https://doi.org/10.1038/s41586-024-08259-2</a>","short":"D. Cheng, K. Wang, C. Roques-Carmes, E. Lustig, O.Y. Long, H. Wang, S. Fan, Nature 637 (2025) 52–56.","mla":"Cheng, Dali, et al. “Non-Abelian Lattice Gauge Fields in Photonic Synthetic Frequency Dimensions.” <i>Nature</i>, vol. 637, no. 8044, Springer Nature, 2025, pp. 52–56, doi:<a href=\"https://doi.org/10.1038/s41586-024-08259-2\">10.1038/s41586-024-08259-2</a>.","ieee":"D. Cheng <i>et al.</i>, “Non-Abelian lattice gauge fields in photonic synthetic frequency dimensions,” <i>Nature</i>, vol. 637, no. 8044. Springer Nature, pp. 52–56, 2025."},"publisher":"Springer Nature","extern":"1","publication":"Nature","issue":"8044","article_processing_charge":"No","OA_type":"green","type":"journal_article","page":"52-56","day":"02","volume":637,"arxiv":1,"publication_status":"published","status":"public","abstract":[{"lang":"eng","text":"Non-Abelian gauge fields provide a conceptual framework to describe particles\r\nhaving spins, underlying many phenomena in electrodynamics, condensed-matter\r\nphysics and particle physics. Lattice models of non-Abelian gauge fields allow us\r\nto understand their physical implications in extended systems. The theoretical\r\nimportance of non-Abelian lattice gauge fields motivates their experimental synthesis\r\nand explorations. Photons are fundamental particles for which artificial gauge fields\r\ncan be synthesized, yet the demonstration of non-Abelian lattice gauge fields for\r\nphotons has not been achieved. Here we demonstrate SU(2) lattice gauge fields for\r\nphotons in the synthetic frequency dimensions, a playground to study lattice\r\nphysics in a scalable and programmable way. In our lattice model, we theoretically\r\nobserve that homogeneous non-Abelian lattice gauge potentials induce Dirac cones\r\nat time-reversal-invariant momenta in the Brillouin zone. We experimentally confirm\r\nthe presence of non-Abelian lattice gauge fields by two signatures: linear band\r\ncrossings at the Dirac cones, and the associated direction reversal of eigenstate\r\ntrajectories. We further demonstrate a non-Abelian scalar lattice gauge potential that\r\nlifts the degeneracies of the Dirac cones. Our results highlight the implications of\r\nnon-Abelian lattice gauge fields in topological physics, and provide a starting point\r\nfor demonstrations of emerging non-Abelian physics in the photonic synthetic\r\ndimensions. Our results may also benefit photonic technologies by providing controls\r\nof photon spins and pseudo-spins in topologically non-trivial ways."}],"_id":"21548","pmid":1,"intvolume":"       637","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2406.00321"}],"doi":"10.1038/s41586-024-08259-2","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"language":[{"iso":"eng"}],"external_id":{"pmid":["39743600"],"arxiv":["2406.00321"]},"month":"01","oa_version":"Preprint","scopus_import":"1","ddc":["530"],"date_published":"2025-01-02T00:00:00Z","author":[{"full_name":"Cheng, Dali","last_name":"Cheng","first_name":"Dali"},{"first_name":"Kai","full_name":"Wang, Kai","last_name":"Wang"},{"id":"e2e68fc9-6505-11ef-a541-eb4e72cc3e82","last_name":"Roques-Carmes","full_name":"Roques-Carmes, Charles","first_name":"Charles"},{"full_name":"Lustig, Eran","last_name":"Lustig","first_name":"Eran"},{"last_name":"Long","full_name":"Long, Olivia Y.","first_name":"Olivia Y."},{"first_name":"Heming","full_name":"Wang, Heming","last_name":"Wang"},{"full_name":"Fan, Shanhui","last_name":"Fan","first_name":"Shanhui"}],"date_updated":"2026-04-27T07:14:06Z","OA_place":"repository"},{"date_updated":"2026-04-27T08:38:44Z","OA_place":"publisher","author":[{"first_name":"Shiyue","full_name":"Hua, Shiyue","last_name":"Hua"},{"last_name":"Divita","full_name":"Divita, Erwan","first_name":"Erwan"},{"first_name":"Shanshan","full_name":"Yu, Shanshan","last_name":"Yu"},{"first_name":"Bo","last_name":"Peng","full_name":"Peng, Bo"},{"first_name":"Charles","last_name":"Roques-Carmes","id":"e2e68fc9-6505-11ef-a541-eb4e72cc3e82","full_name":"Roques-Carmes, Charles"},{"first_name":"Zhan","last_name":"Su","full_name":"Su, Zhan"},{"full_name":"Chen, Zhang","last_name":"Chen","first_name":"Zhang"},{"first_name":"Yanfei","full_name":"Bai, Yanfei","last_name":"Bai"},{"full_name":"Zou, Jinghui","last_name":"Zou","first_name":"Jinghui"},{"first_name":"Yunpeng","last_name":"Zhu","full_name":"Zhu, Yunpeng"},{"first_name":"Yelong","last_name":"Xu","full_name":"Xu, Yelong"},{"last_name":"Lu","full_name":"Lu, Cheng-kuan","first_name":"Cheng-kuan"},{"last_name":"Di","full_name":"Di, Yuemiao","first_name":"Yuemiao"},{"full_name":"Chen, Hui","last_name":"Chen","first_name":"Hui"},{"last_name":"Jiang","full_name":"Jiang, Lushan","first_name":"Lushan"},{"full_name":"Wang, Lijie","last_name":"Wang","first_name":"Lijie"},{"first_name":"Longwu","last_name":"Ou","full_name":"Ou, Longwu"},{"first_name":"Chaohong","last_name":"Zhang","full_name":"Zhang, Chaohong"},{"first_name":"Junjie","last_name":"Chen","full_name":"Chen, Junjie"},{"first_name":"Wen","full_name":"Zhang, Wen","last_name":"Zhang"},{"last_name":"Zhu","full_name":"Zhu, Hongyan","first_name":"Hongyan"},{"first_name":"Weijun","full_name":"Kuang, Weijun","last_name":"Kuang"},{"full_name":"Wang, Long","last_name":"Wang","first_name":"Long"},{"full_name":"Meng, Huaiyu","last_name":"Meng","first_name":"Huaiyu"},{"last_name":"Steinman","full_name":"Steinman, Maurice","first_name":"Maurice"},{"full_name":"Shen, Yichen","last_name":"Shen","first_name":"Yichen"}],"ddc":["530"],"date_published":"2025-04-09T00:00:00Z","scopus_import":"1","oa_version":"Published Version","month":"04","external_id":{"pmid":[" 40205213"]},"language":[{"iso":"eng"}],"publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"doi":"10.1038/s41586-025-08786-6","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png"},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41586-025-08786-6"}],"status":"public","pmid":1,"_id":"21549","intvolume":"       640","abstract":[{"text":"Integrated photonics, particularly silicon photonics, have emerged as cutting-edge technology driven by promising applications such as short-reach communications, autonomous driving, biosensing and photonic computing1,2,3,4. As advances in AI lead to growing computing demands, photonic computing has gained considerable attention as an appealing candidate. Nonetheless, there are substantial technical challenges in the scaling up of integrated photonics systems to realize these advantages, such as ensuring consistent performance gains in upscaled integrated device clusters, establishing standard designs and verification processes for complex circuits, as well as packaging large-scale systems. These obstacles arise primarily because of the relative immaturity of integrated photonics manufacturing and the scarcity of advanced packaging solutions involving photonics. Here we report a large-scale integrated photonic accelerator comprising more than 16,000 photonic components. The accelerator is designed to deliver standard linear matrix multiply–accumulate (MAC) functions, enabling computing with high speed up to 1 GHz frequency and low latency as small as 3 ns per cycle. Logic, memory and control functions that support photonic matrix MAC operations were designed into a cointegrated electronics chip. To seamlessly integrate the electronics and photonics chips at the commercial scale, we have made use of an innovative 2.5D hybrid advanced packaging approach. Through the development of this accelerator system, we demonstrate an ultralow computation latency for heuristic solvers of computationally hard Ising problems whose performance greatly relies on the computing latency.","lang":"eng"}],"publication_status":"published","page":"361-367","day":"09","volume":640,"type":"journal_article","article_processing_charge":"No","OA_type":"hybrid","publisher":"Springer Nature","extern":"1","publication":"Nature","citation":{"mla":"Hua, Shiyue, et al. “An Integrated Large-Scale Photonic Accelerator with Ultralow Latency.” <i>Nature</i>, vol. 640, Springer Nature, 2025, pp. 361–67, doi:<a href=\"https://doi.org/10.1038/s41586-025-08786-6\">10.1038/s41586-025-08786-6</a>.","short":"S. Hua, E. Divita, S. Yu, B. Peng, C. Roques-Carmes, Z. Su, Z. Chen, Y. Bai, J. Zou, Y. Zhu, Y. Xu, C. Lu, Y. Di, H. Chen, L. Jiang, L. Wang, L. Ou, C. Zhang, J. Chen, W. Zhang, H. Zhu, W. Kuang, L. Wang, H. Meng, M. Steinman, Y. Shen, Nature 640 (2025) 361–367.","ieee":"S. Hua <i>et al.</i>, “An integrated large-scale photonic accelerator with ultralow latency,” <i>Nature</i>, vol. 640. Springer Nature, pp. 361–367, 2025.","ama":"Hua S, Divita E, Yu S, et al. An integrated large-scale photonic accelerator with ultralow latency. <i>Nature</i>. 2025;640:361-367. doi:<a href=\"https://doi.org/10.1038/s41586-025-08786-6\">10.1038/s41586-025-08786-6</a>","ista":"Hua S, Divita E, Yu S, Peng B, Roques-Carmes C, Su Z, Chen Z, Bai Y, Zou J, Zhu Y, Xu Y, Lu C, Di Y, Chen H, Jiang L, Wang L, Ou L, Zhang C, Chen J, Zhang W, Zhu H, Kuang W, Wang L, Meng H, Steinman M, Shen Y. 2025. An integrated large-scale photonic accelerator with ultralow latency. Nature. 640, 361–367.","apa":"Hua, S., Divita, E., Yu, S., Peng, B., Roques-Carmes, C., Su, Z., … Shen, Y. (2025). An integrated large-scale photonic accelerator with ultralow latency. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-025-08786-6\">https://doi.org/10.1038/s41586-025-08786-6</a>","chicago":"Hua, Shiyue, Erwan Divita, Shanshan Yu, Bo Peng, Charles Roques-Carmes, Zhan Su, Zhang Chen, et al. “An Integrated Large-Scale Photonic Accelerator with Ultralow Latency.” <i>Nature</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41586-025-08786-6\">https://doi.org/10.1038/s41586-025-08786-6</a>."},"oa":1,"article_type":"original","quality_controlled":"1","year":"2025","date_created":"2026-03-30T12:22:47Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"An integrated large-scale photonic accelerator with ultralow latency"},{"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","title":"Quantum scars make their mark in graphene","article_type":"letter_note","quality_controlled":"1","year":"2024","date_created":"2024-12-03T18:08:16Z","citation":{"ama":"Abanin D, Serbyn M. Quantum scars make their mark in graphene. <i>Nature</i>. 2024;635(8040):825-826. doi:<a href=\"https://doi.org/10.1038/d41586-024-03649-y\">10.1038/d41586-024-03649-y</a>","ista":"Abanin D, Serbyn M. 2024. Quantum scars make their mark in graphene. Nature. 635(8040), 825–826.","apa":"Abanin, D., &#38; Serbyn, M. (2024). Quantum scars make their mark in graphene. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/d41586-024-03649-y\">https://doi.org/10.1038/d41586-024-03649-y</a>","chicago":"Abanin, Dmitry, and Maksym Serbyn. “Quantum Scars Make Their Mark in Graphene.” <i>Nature</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/d41586-024-03649-y\">https://doi.org/10.1038/d41586-024-03649-y</a>.","mla":"Abanin, Dmitry, and Maksym Serbyn. “Quantum Scars Make Their Mark in Graphene.” <i>Nature</i>, vol. 635, no. 8040, Springer Nature, 2024, pp. 825–26, doi:<a href=\"https://doi.org/10.1038/d41586-024-03649-y\">10.1038/d41586-024-03649-y</a>.","short":"D. Abanin, M. Serbyn, Nature 635 (2024) 825–826.","ieee":"D. Abanin and M. Serbyn, “Quantum scars make their mark in graphene,” <i>Nature</i>, vol. 635, no. 8040. Springer Nature, pp. 825–826, 2024."},"article_processing_charge":"No","OA_type":"closed access","publisher":"Springer Nature","publication":"Nature","issue":"8040","page":"825-826","day":"27","volume":635,"type":"journal_article","publication_status":"published","status":"public","abstract":[{"text":"By patterning an ultrathin layered structure with tiny wells, physicists have created and imaged peculiar states known as quantum scars — revealing behaviour that could be used to boost the performance of electronic devices.","lang":"eng"}],"_id":"18616","intvolume":"       635","pmid":1,"isi":1,"department":[{"_id":"MaSe"}],"doi":"10.1038/d41586-024-03649-y","publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"external_id":{"isi":["001367935000029"],"pmid":["39604614"]},"language":[{"iso":"eng"}],"oa_version":"None","scopus_import":"1","month":"11","author":[{"full_name":"Abanin, Dmitry","last_name":"Abanin","first_name":"Dmitry"},{"id":"47809E7E-F248-11E8-B48F-1D18A9856A87","full_name":"Serbyn, Maksym","last_name":"Serbyn","first_name":"Maksym","orcid":"0000-0002-2399-5827"}],"date_published":"2024-11-27T00:00:00Z","date_updated":"2025-09-08T14:57:35Z"},{"author":[{"full_name":"Gärtner, Florian R","id":"397A88EE-F248-11E8-B48F-1D18A9856A87","last_name":"Gärtner","orcid":"0000-0001-6120-3723","first_name":"Florian R"},{"full_name":"Ishikawa-Ankerhold, Hellen","last_name":"Ishikawa-Ankerhold","first_name":"Hellen"},{"full_name":"Stutte, Susanne","last_name":"Stutte","first_name":"Susanne"},{"full_name":"Fu, Wenwen","last_name":"Fu","first_name":"Wenwen"},{"full_name":"Weitz, Jutta","last_name":"Weitz","first_name":"Jutta"},{"first_name":"Anne","full_name":"Dueck, Anne","last_name":"Dueck"},{"first_name":"Bhavishya","last_name":"Nelakuditi","full_name":"Nelakuditi, Bhavishya"},{"first_name":"Valeria","full_name":"Fumagalli, Valeria","last_name":"Fumagalli"},{"first_name":"Dominic","last_name":"Van Den Heuvel","full_name":"Van Den Heuvel, Dominic"},{"first_name":"Larissa","last_name":"Belz","full_name":"Belz, Larissa"},{"first_name":"Gulnoza","full_name":"Sobirova, Gulnoza","last_name":"Sobirova"},{"first_name":"Zhe","full_name":"Zhang, Zhe","last_name":"Zhang"},{"first_name":"Anna","last_name":"Titova","full_name":"Titova, Anna"},{"last_name":"Navarro","full_name":"Navarro, Alejandro Martinez","first_name":"Alejandro Martinez"},{"first_name":"Kami","last_name":"Pekayvaz","full_name":"Pekayvaz, Kami"},{"first_name":"Michael","full_name":"Lorenz, Michael","last_name":"Lorenz"},{"last_name":"Von Baumgarten","full_name":"Von Baumgarten, Louisa","first_name":"Louisa"},{"last_name":"Kranich","full_name":"Kranich, Jan","first_name":"Jan"},{"first_name":"Tobias","full_name":"Straub, Tobias","last_name":"Straub"},{"first_name":"Bastian","last_name":"Popper","full_name":"Popper, Bastian"},{"orcid":"0000-0002-9438-4783","first_name":"Vanessa","last_name":"Zheden","full_name":"Zheden, Vanessa","id":"39C5A68A-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0001-9735-5315","first_name":"Walter","id":"3F99E422-F248-11E8-B48F-1D18A9856A87","last_name":"Kaufmann","full_name":"Kaufmann, Walter"},{"last_name":"Guo","full_name":"Guo, Chenglong","first_name":"Chenglong"},{"first_name":"Guido","full_name":"Piontek, Guido","last_name":"Piontek"},{"first_name":"Saskia","last_name":"Von Stillfried","full_name":"Von Stillfried, Saskia"},{"last_name":"Boor","full_name":"Boor, Peter","first_name":"Peter"},{"last_name":"Colonna","full_name":"Colonna, Marco","first_name":"Marco"},{"full_name":"Clauß, Sebastian","last_name":"Clauß","first_name":"Sebastian"},{"full_name":"Schulz, Christian","last_name":"Schulz","first_name":"Christian"},{"full_name":"Brocker, Thomas","last_name":"Brocker","first_name":"Thomas"},{"full_name":"Walzog, Barbara","last_name":"Walzog","first_name":"Barbara"},{"full_name":"Scheiermann, Christoph","last_name":"Scheiermann","first_name":"Christoph"},{"last_name":"Aird","full_name":"Aird, William C.","first_name":"William C."},{"first_name":"Claus","last_name":"Nerlov","full_name":"Nerlov, Claus"},{"last_name":"Stark","full_name":"Stark, Konstantin","first_name":"Konstantin"},{"first_name":"Tobias","last_name":"Petzold","full_name":"Petzold, Tobias"},{"last_name":"Engelhardt","full_name":"Engelhardt, Stefan","first_name":"Stefan"},{"orcid":"0000-0002-6620-9179","first_name":"Michael K","last_name":"Sixt","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K"},{"orcid":"0000-0001-9843-3522","first_name":"Robert","last_name":"Hauschild","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","full_name":"Hauschild, Robert"},{"last_name":"Rudelius","full_name":"Rudelius, Martina","first_name":"Martina"},{"full_name":"Oostendorp, Robert A.J.","last_name":"Oostendorp","first_name":"Robert A.J."},{"full_name":"Iannacone, Matteo","last_name":"Iannacone","first_name":"Matteo"},{"full_name":"Heinig, Matthias","last_name":"Heinig","first_name":"Matthias"},{"first_name":"Steffen","full_name":"Massberg, Steffen","last_name":"Massberg"}],"date_published":"2024-07-18T00:00:00Z","ddc":["570"],"date_updated":"2025-09-08T08:14:25Z","project":[{"grant_number":"747687","name":"Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells","call_identifier":"H2020","_id":"260AA4E2-B435-11E9-9278-68D0E5697425"}],"external_id":{"isi":["001281636500020"],"pmid":["38987596"]},"language":[{"iso":"eng"}],"oa_version":"Published Version","scopus_import":"1","has_accepted_license":"1","month":"07","doi":"10.1038/s41586-024-07671-y","acknowledgement":"We thank S. Helmer, N. Blount, E. Raatz and Z. Sisic for technical assistance. This work was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) SFB 1123 (S.M. project B06); SFB 914 (S.M. projects B02 and Z01, H.I.-A. project Z01, S.S. project A06, K.S. project B02, C. Schulz project A10, B.W. project A02, C. Scheiermann project B09); SFB 1054 (T.B. project B03); FOR2033 (F.G., R.A.J.O., S.M.); Individual research grant project ID: 514478744 (F.G.); Heisenberg Programme project ID: 514477451 (F.G.); the DZHK (German Center for Cardiovascular Research) (MHA 1.4VD (S.M.), Postdoc Start-up Grant, 81×3600213 (F.G.)); and LMUexcellence NFF (F.G.). W.F. received funding from China Scholarship Council (CSC, no. 201306270012). P.B. is supported by the German Research Foundation (DFG, project IDs 322900939, 432698239 and 445703531), European Research Council (ERC Consolidator grant no. 101001791) and the Federal Ministry of Education and Research (BMBF, STOP-FSGS-01GM2202C and NATON within the framework of the Network of University Medicine, no. 01KX2121). S.v.S. is supported by the START-Program of the Faculty of Medicine of the RWTH Aachen University (AZ 125/17). A.D. and S.E. are supported by the German Research Foundation (SFB TRR 267); S.E. by the BMBF in the framework of the Cluster4future program (CNATM—Cluster for Nucleic Acid Therapeutics Munich). This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 833440 to S.M.). F.G. received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 747687. The project is funded by the European Union (ERC, MEKanics, 101078110). Views and opinions expressed are those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.","publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"department":[{"_id":"EM-Fac"},{"_id":"MiSi"},{"_id":"Bio"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"isi":1,"publication_status":"published","file":[{"relation":"main_file","content_type":"application/pdf","date_created":"2024-07-22T06:16:11Z","file_name":"2024_Nature_Gaertner.pdf","creator":"dernst","success":1,"date_updated":"2024-07-22T06:16:11Z","file_size":15704819,"checksum":"aa004afc72d2489f0fb0fcbc9919fbbd","file_id":"17286","access_level":"open_access"}],"abstract":[{"lang":"eng","text":"Platelet homeostasis is essential for vascular integrity and immune defence1,2. Although the process of platelet formation by fragmenting megakaryocytes (MKs; thrombopoiesis) has been extensively studied, the cellular and molecular mechanisms required to constantly replenish the pool of MKs by their progenitor cells (megakaryopoiesis) remains unclear3,4. Here we use intravital imaging to track the cellular dynamics of megakaryopoiesis over days. We identify plasmacytoid dendritic cells (pDCs) as homeostatic sensors that monitor the bone marrow for apoptotic MKs and deliver IFNα to the MK niche triggering local on-demand proliferation and maturation of MK progenitors. This pDC-dependent feedback loop is crucial for MK and platelet homeostasis at steady state and under stress. pDCs are best known for their ability to function as vigilant detectors of viral infection5. We show that virus-induced activation of pDCs interferes with their function as homeostatic sensors of megakaryopoiesis. Consequently, activation of pDCs by SARS-CoV-2 leads to excessive megakaryopoiesis. Together, we identify a pDC-dependent homeostatic circuit that involves innate immune sensing and demand-adapted release of inflammatory mediators to maintain homeostasis of the megakaryocytic lineage."}],"_id":"17284","intvolume":"       631","pmid":1,"status":"public","article_processing_charge":"Yes (in subscription journal)","publication":"Nature","publisher":"Springer Nature","volume":631,"page":"645-653","day":"18","type":"journal_article","corr_author":"1","quality_controlled":"1","article_type":"original","date_created":"2024-07-21T22:01:02Z","year":"2024","citation":{"mla":"Gärtner, Florian R., et al. “Plasmacytoid Dendritic Cells Control Homeostasis of Megakaryopoiesis.” <i>Nature</i>, vol. 631, Springer Nature, 2024, pp. 645–53, doi:<a href=\"https://doi.org/10.1038/s41586-024-07671-y\">10.1038/s41586-024-07671-y</a>.","ieee":"F. R. Gärtner <i>et al.</i>, “Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis,” <i>Nature</i>, vol. 631. Springer Nature, pp. 645–653, 2024.","short":"F.R. Gärtner, H. Ishikawa-Ankerhold, S. Stutte, W. Fu, J. Weitz, A. Dueck, B. Nelakuditi, V. Fumagalli, D. Van Den Heuvel, L. Belz, G. Sobirova, Z. Zhang, A. Titova, A.M. Navarro, K. Pekayvaz, M. Lorenz, L. Von Baumgarten, J. Kranich, T. Straub, B. Popper, V. Zheden, W. Kaufmann, C. Guo, G. Piontek, S. Von Stillfried, P. Boor, M. Colonna, S. Clauß, C. Schulz, T. Brocker, B. Walzog, C. Scheiermann, W.C. Aird, C. Nerlov, K. Stark, T. Petzold, S. Engelhardt, M.K. Sixt, R. Hauschild, M. Rudelius, R.A.J. Oostendorp, M. Iannacone, M. Heinig, S. Massberg, Nature 631 (2024) 645–653.","chicago":"Gärtner, Florian R, Hellen Ishikawa-Ankerhold, Susanne Stutte, Wenwen Fu, Jutta Weitz, Anne Dueck, Bhavishya Nelakuditi, et al. “Plasmacytoid Dendritic Cells Control Homeostasis of Megakaryopoiesis.” <i>Nature</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41586-024-07671-y\">https://doi.org/10.1038/s41586-024-07671-y</a>.","apa":"Gärtner, F. R., Ishikawa-Ankerhold, H., Stutte, S., Fu, W., Weitz, J., Dueck, A., … Massberg, S. (2024). Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-024-07671-y\">https://doi.org/10.1038/s41586-024-07671-y</a>","ista":"Gärtner FR, Ishikawa-Ankerhold H, Stutte S, Fu W, Weitz J, Dueck A, Nelakuditi B, Fumagalli V, Van Den Heuvel D, Belz L, Sobirova G, Zhang Z, Titova A, Navarro AM, Pekayvaz K, Lorenz M, Von Baumgarten L, Kranich J, Straub T, Popper B, Zheden V, Kaufmann W, Guo C, Piontek G, Von Stillfried S, Boor P, Colonna M, Clauß S, Schulz C, Brocker T, Walzog B, Scheiermann C, Aird WC, Nerlov C, Stark K, Petzold T, Engelhardt S, Sixt MK, Hauschild R, Rudelius M, Oostendorp RAJ, Iannacone M, Heinig M, Massberg S. 2024. Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis. Nature. 631, 645–653.","ama":"Gärtner FR, Ishikawa-Ankerhold H, Stutte S, et al. Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis. <i>Nature</i>. 2024;631:645-653. doi:<a href=\"https://doi.org/10.1038/s41586-024-07671-y\">10.1038/s41586-024-07671-y</a>"},"oa":1,"related_material":{"link":[{"relation":"software","url":"https://github.com/heiniglab/gaertner_megakaryocytes"}]},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","file_date_updated":"2024-07-22T06:16:11Z","title":"Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis","ec_funded":1},{"department":[{"_id":"JaBr"}],"publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"acknowledgement":"We thank K. Kiernan, G. Hibshman and I. Strohkendl for insightful discussions and comments on the manuscript, and R. Lin for assistance with the ATPase assay. Data were collected at the Sauer Structural Biology Laboratory at the University of Texas at Austin. This work was supported in part by the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH) R35GM138348 (to D.W.T.) and Welch Foundation research grant F-1938 (to D.W.T.).","doi":"10.1038/s41586-024-07515-9","month":"06","scopus_import":"1","oa_version":"Submitted Version","language":[{"iso":"eng"}],"external_id":{"pmid":["38740055"]},"date_updated":"2025-06-24T12:47:21Z","OA_place":"repository","date_published":"2024-06-27T00:00:00Z","author":[{"orcid":"0000-0003-0456-0753","first_name":"Jack Peter Kelly","full_name":"Bravo, Jack Peter Kelly","last_name":"Bravo","id":"96aecfa5-8931-11ee-af30-aa6a5d6eee0e"},{"last_name":"Ramos","full_name":"Ramos, Delisa A.","first_name":"Delisa A."},{"first_name":"Rodrigo","last_name":"Fregoso Ocampo","full_name":"Fregoso Ocampo, Rodrigo"},{"first_name":"Caiden","last_name":"Ingram","full_name":"Ingram, Caiden"},{"first_name":"David W.","full_name":"Taylor, David W.","last_name":"Taylor"}],"title":"Plasmid targeting and destruction by the DdmDE bacterial defence system","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"citation":{"ieee":"J. P. K. Bravo, D. A. Ramos, R. Fregoso Ocampo, C. Ingram, and D. W. Taylor, “Plasmid targeting and destruction by the DdmDE bacterial defence system,” <i>Nature</i>, vol. 630, no. 8018. Springer Nature, pp. 961–967, 2024.","short":"J.P.K. Bravo, D.A. Ramos, R. Fregoso Ocampo, C. Ingram, D.W. Taylor, Nature 630 (2024) 961–967.","mla":"Bravo, Jack Peter Kelly, et al. “Plasmid Targeting and Destruction by the DdmDE Bacterial Defence System.” <i>Nature</i>, vol. 630, no. 8018, Springer Nature, 2024, pp. 961–67, doi:<a href=\"https://doi.org/10.1038/s41586-024-07515-9\">10.1038/s41586-024-07515-9</a>.","chicago":"Bravo, Jack Peter Kelly, Delisa A. Ramos, Rodrigo Fregoso Ocampo, Caiden Ingram, and David W. Taylor. “Plasmid Targeting and Destruction by the DdmDE Bacterial Defence System.” <i>Nature</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41586-024-07515-9\">https://doi.org/10.1038/s41586-024-07515-9</a>.","apa":"Bravo, J. P. K., Ramos, D. A., Fregoso Ocampo, R., Ingram, C., &#38; Taylor, D. W. (2024). Plasmid targeting and destruction by the DdmDE bacterial defence system. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-024-07515-9\">https://doi.org/10.1038/s41586-024-07515-9</a>","ista":"Bravo JPK, Ramos DA, Fregoso Ocampo R, Ingram C, Taylor DW. 2024. Plasmid targeting and destruction by the DdmDE bacterial defence system. Nature. 630(8018), 961–967.","ama":"Bravo JPK, Ramos DA, Fregoso Ocampo R, Ingram C, Taylor DW. Plasmid targeting and destruction by the DdmDE bacterial defence system. <i>Nature</i>. 2024;630(8018):961-967. doi:<a href=\"https://doi.org/10.1038/s41586-024-07515-9\">10.1038/s41586-024-07515-9</a>"},"year":"2024","date_created":"2024-08-19T09:41:18Z","article_type":"original","quality_controlled":"1","corr_author":"1","type":"journal_article","page":"961-967","day":"27","volume":630,"publisher":"Springer Nature","publication":"Nature","issue":"8018","article_processing_charge":"No","OA_type":"green","status":"public","_id":"17442","abstract":[{"lang":"eng","text":"Although eukaryotic Argonautes have a pivotal role in post-transcriptional gene regulation through nucleic acid cleavage, some short prokaryotic Argonaute variants (pAgos) rely on auxiliary nuclease factors for efficient foreign DNA degradation1. Here we reveal the activation pathway of the DNA defence module DdmDE system, which rapidly eliminates small, multicopy plasmids from the Vibrio cholerae seventh pandemic strain (7PET)2. Through a combination of cryo-electron microscopy, biochemistry and in vivo plasmid clearance assays, we demonstrate that DdmE is a catalytically inactive, DNA-guided, DNA-targeting pAgo with a distinctive insertion domain. We observe that the helicase-nuclease DdmD transitions from an autoinhibited, dimeric complex to a monomeric state upon loading of single-stranded DNA targets. Furthermore, the complete structure of the DdmDE–guide–target handover complex provides a comprehensive view into how DNA recognition triggers processive plasmid destruction. Our work establishes a mechanistic foundation for how pAgos utilize ancillary factors to achieve plasmid clearance, and provides insights into anti-plasmid immunity in bacteria.\r\n\r\n"}],"pmid":1,"intvolume":"       630","main_file_link":[{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11649018/","open_access":"1"}],"publication_status":"published"},{"article_processing_charge":"Yes (in subscription journal)","publication":"Nature","publisher":"Springer Nature","volume":632,"page":"911–920 ","day":"22","type":"journal_article","publication_status":"published","file":[{"file_size":16572040,"checksum":"39127601621a360ec0edc538627eb211","access_level":"open_access","file_id":"18005","file_name":"2024_Nature_Pillai.pdf","date_created":"2024-09-09T12:01:14Z","relation":"main_file","content_type":"application/pdf","date_updated":"2024-09-09T12:01:14Z","success":1,"creator":"dernst"}],"_id":"17463","intvolume":"       632","pmid":1,"abstract":[{"text":"Allosteric modulation of protein function, wherein the binding of an effector to a protein triggers conformational changes at distant functional sites, plays a central part in the control of metabolism and cell signalling1,2,3. There has been considerable interest in designing allosteric systems, both to gain insight into the mechanisms underlying such ‘action at a distance’ modulation and to create synthetic proteins whose functions can be regulated by effectors4,5,6,7. However, emulating the subtle conformational changes distributed across many residues, characteristic of natural allosteric proteins, is a significant challenge8,9. Here, inspired by the classic Monod–Wyman–Changeux model of cooperativity10, we investigate the de novo design of allostery through rigid-body coupling of peptide-switchable hinge modules11 to protein interfaces12 that direct the formation of alternative oligomeric states. We find that this approach can be used to generate a wide variety of allosterically switchable systems, including cyclic rings that incorporate or eject subunits in response to peptide binding and dihedral cages that undergo effector-induced disassembly. Size-exclusion chromatography, mass photometry13 and electron microscopy reveal that these designed allosteric protein assemblies closely resemble the design models in both the presence and absence of peptide effectors and can have ligand-binding cooperativity comparable to classic natural systems such as haemoglobin14. Our results indicate that allostery can arise from global coupling of the energetics of protein substructures without optimized side-chain–side-chain allosteric communication pathways and provide a roadmap for generating allosterically triggerable delivery systems, protein nanomachines and cellular feedback control circuitry.","lang":"eng"}],"status":"public","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","file_date_updated":"2024-09-09T12:01:14Z","title":"De novo design of allosterically switchable protein assemblies","quality_controlled":"1","corr_author":"1","article_type":"original","date_created":"2024-08-25T22:01:08Z","year":"2024","citation":{"short":"A. Pillai, A. Idris, A. Philomin, C. Weidle, R. Skotheim, P.J.Y. Leung, A. Broerman, C. Demakis, A.J. Borst, F.M. Praetorius, D. Baker, Nature 632 (2024) 911–920.","ieee":"A. Pillai <i>et al.</i>, “De novo design of allosterically switchable protein assemblies,” <i>Nature</i>, vol. 632. Springer Nature, pp. 911–920, 2024.","mla":"Pillai, Arvind, et al. “De Novo Design of Allosterically Switchable Protein Assemblies.” <i>Nature</i>, vol. 632, Springer Nature, 2024, pp. 911–920, doi:<a href=\"https://doi.org/10.1038/s41586-024-07813-2\">10.1038/s41586-024-07813-2</a>.","apa":"Pillai, A., Idris, A., Philomin, A., Weidle, C., Skotheim, R., Leung, P. J. Y., … Baker, D. (2024). De novo design of allosterically switchable protein assemblies. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-024-07813-2\">https://doi.org/10.1038/s41586-024-07813-2</a>","chicago":"Pillai, Arvind, Abbas Idris, Annika Philomin, Connor Weidle, Rebecca Skotheim, Philip J.Y. Leung, Adam Broerman, et al. “De Novo Design of Allosterically Switchable Protein Assemblies.” <i>Nature</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41586-024-07813-2\">https://doi.org/10.1038/s41586-024-07813-2</a>.","ama":"Pillai A, Idris A, Philomin A, et al. De novo design of allosterically switchable protein assemblies. <i>Nature</i>. 2024;632:911–920. doi:<a href=\"https://doi.org/10.1038/s41586-024-07813-2\">10.1038/s41586-024-07813-2</a>","ista":"Pillai A, Idris A, Philomin A, Weidle C, Skotheim R, Leung PJY, Broerman A, Demakis C, Borst AJ, Praetorius FM, Baker D. 2024. De novo design of allosterically switchable protein assemblies. Nature. 632, 911–920."},"oa":1,"external_id":{"pmid":["39143214"],"isi":["001300534300019"]},"language":[{"iso":"eng"}],"scopus_import":"1","oa_version":"Published Version","has_accepted_license":"1","month":"08","author":[{"last_name":"Pillai","full_name":"Pillai, Arvind","first_name":"Arvind"},{"full_name":"Idris, Abbas","last_name":"Idris","first_name":"Abbas"},{"first_name":"Annika","last_name":"Philomin","full_name":"Philomin, Annika"},{"last_name":"Weidle","full_name":"Weidle, Connor","first_name":"Connor"},{"full_name":"Skotheim, Rebecca","last_name":"Skotheim","first_name":"Rebecca"},{"first_name":"Philip J.Y.","full_name":"Leung, Philip J.Y.","last_name":"Leung"},{"full_name":"Broerman, Adam","last_name":"Broerman","first_name":"Adam"},{"first_name":"Cullen","last_name":"Demakis","full_name":"Demakis, Cullen"},{"full_name":"Borst, Andrew J.","last_name":"Borst","first_name":"Andrew J."},{"first_name":"Florian M","full_name":"Praetorius, Florian M","last_name":"Praetorius","id":"dfec9381-4341-11ee-8fd8-faa02bba7d62"},{"first_name":"David","full_name":"Baker, David","last_name":"Baker"}],"date_published":"2024-08-22T00:00:00Z","ddc":["570"],"date_updated":"2025-09-08T09:00:16Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png"},"isi":1,"department":[{"_id":"FlPr"}],"doi":"10.1038/s41586-024-07813-2","acknowledgement":"We thank D. D. Sahtoe, R. D. Kiber, Y. Hsia, N. Bethel and A. Favor for helpful discussions and K. VanWormer and L. Goldschmidt for technical support. We also thank X. Li and M. Lamb for mass spectrometry support. This work was supported by the Washington Research Foundation Postdoctoral Fellowship (grant no. GR027504, A. Pillai), a National Science Foundation Graduate Research Fellowship (grant no. DGE-2140004, A.I.), a Human Frontier Science Program Long Term Fellowship (grant no. LT000880/2019, F.P.), the Audacious Project at the Institute for Protein Design (A.B., A. Pillai, A. Philomin, A.I. and D.B.), a National Energy Research Scientific Computing Centre award (grant no. BER-ERCAP0022018), the Howard Hughes Medical Institute (D.B.), the Open Philanthropy Project Improving Protein Design Fund (P.J.Y.L., C.D. and D.B.) a gift from Microsoft (D.B.) and a grant from DARPA supporting the Harnessing Enzymatic Activity for Lifesaving Remedies programme (grant no. HR001120S0052, contract no. HR0011-21-2-0012, D.B.).","publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]}},{"department":[{"_id":"BjHo"}],"isi":1,"doi":"10.1038/s41586-023-06399-5","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"acknowledgement":"We acknowledge the assistance of the Miba machine shop and the team of the ISTA-HPC cluster. We thank M. Quadrio for the discussions. The work was supported by the Simons Foundation (grant no. 662960) and by the Austrian Science Fund (grant no. I4188-N30), within Deutsche Forschungsgemeinschaft research unit FOR 2688.","acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"ScienComp"}],"language":[{"iso":"eng"}],"external_id":{"pmid":["37673988"],"isi":["001168947700009"]},"month":"09","has_accepted_license":"1","oa_version":"Submitted Version","scopus_import":"1","ddc":["530"],"date_published":"2023-09-07T00:00:00Z","author":[{"orcid":"0000-0001-5227-4271","first_name":"Davide","id":"40315C30-F248-11E8-B48F-1D18A9856A87","full_name":"Scarselli, Davide","last_name":"Scarselli"},{"first_name":"Jose M","orcid":"0000-0002-0384-2022","id":"40770848-F248-11E8-B48F-1D18A9856A87","last_name":"Lopez Alonso","full_name":"Lopez Alonso, Jose M"},{"full_name":"Varshney, Atul","last_name":"Varshney","id":"2A2006B2-F248-11E8-B48F-1D18A9856A87","first_name":"Atul","orcid":"0000-0002-3072-5999"},{"id":"3A374330-F248-11E8-B48F-1D18A9856A87","full_name":"Hof, Björn","last_name":"Hof","first_name":"Björn","orcid":"0000-0003-2057-2754"}],"date_updated":"2025-09-09T12:59:04Z","project":[{"name":"Revisiting the Turbulence Problem Using Statistical Mechanics","_id":"238598C6-32DE-11EA-91FC-C7463DDC885E","grant_number":"662960"},{"call_identifier":"FWF","_id":"238B8092-32DE-11EA-91FC-C7463DDC885E","name":"Instabilities in pulsating pipe flow in complex fluids","grant_number":"I04188"}],"title":"Turbulence suppression by cardiac-cycle-inspired driving of pipe flow","file_date_updated":"2024-06-04T09:24:34Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","related_material":{"link":[{"description":"News on ISTA website","url":"https://www.ista.ac.at/en/news/pumping-like-the-heart/","relation":"press_release"}]},"year":"2023","date_created":"2023-09-17T22:01:09Z","article_type":"original","corr_author":"1","quality_controlled":"1","oa":1,"citation":{"ista":"Scarselli D, Lopez Alonso JM, Varshney A, Hof B. 2023. Turbulence suppression by cardiac-cycle-inspired driving of pipe flow. Nature. 621(7977), 71–74.","ama":"Scarselli D, Lopez Alonso JM, Varshney A, Hof B. Turbulence suppression by cardiac-cycle-inspired driving of pipe flow. <i>Nature</i>. 2023;621(7977):71-74. doi:<a href=\"https://doi.org/10.1038/s41586-023-06399-5\">10.1038/s41586-023-06399-5</a>","chicago":"Scarselli, Davide, Jose M Lopez Alonso, Atul Varshney, and Björn Hof. “Turbulence Suppression by Cardiac-Cycle-Inspired Driving of Pipe Flow.” <i>Nature</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41586-023-06399-5\">https://doi.org/10.1038/s41586-023-06399-5</a>.","apa":"Scarselli, D., Lopez Alonso, J. M., Varshney, A., &#38; Hof, B. (2023). Turbulence suppression by cardiac-cycle-inspired driving of pipe flow. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-023-06399-5\">https://doi.org/10.1038/s41586-023-06399-5</a>","ieee":"D. Scarselli, J. M. Lopez Alonso, A. Varshney, and B. Hof, “Turbulence suppression by cardiac-cycle-inspired driving of pipe flow,” <i>Nature</i>, vol. 621, no. 7977. Springer Nature, pp. 71–74, 2023.","short":"D. Scarselli, J.M. Lopez Alonso, A. Varshney, B. Hof, Nature 621 (2023) 71–74.","mla":"Scarselli, Davide, et al. “Turbulence Suppression by Cardiac-Cycle-Inspired Driving of Pipe Flow.” <i>Nature</i>, vol. 621, no. 7977, Springer Nature, 2023, pp. 71–74, doi:<a href=\"https://doi.org/10.1038/s41586-023-06399-5\">10.1038/s41586-023-06399-5</a>."},"publisher":"Springer Nature","publication":"Nature","issue":"7977","article_processing_charge":"No","type":"journal_article","page":"71-74","day":"07","volume":621,"file":[{"file_name":"2023_submittedversion.pdf","date_created":"2024-06-04T09:24:34Z","content_type":"application/pdf","relation":"main_file","date_updated":"2024-06-04T09:24:34Z","creator":"dernst","success":1,"checksum":"9c9f172ba0a9a301d76fff4229812464","file_size":3247252,"access_level":"open_access","file_id":"17118"}],"publication_status":"published","status":"public","intvolume":"       621","_id":"14341","abstract":[{"text":"Flows through pipes and channels are, in practice, almost always turbulent, and the multiscale eddying motion is responsible for a major part of the encountered friction losses and pumping costs1. Conversely, for pulsatile flows, in particular for aortic blood flow, turbulence levels remain low despite relatively large peak velocities. For aortic blood flow, high turbulence levels are intolerable as they would damage the shear-sensitive endothelial cell layer2,3,4,5. Here we show that turbulence in ordinary pipe flow is diminished if the flow is driven in a pulsatile mode that incorporates all the key features of the cardiac waveform. At Reynolds numbers comparable to those of aortic blood flow, turbulence is largely inhibited, whereas at much higher speeds, the turbulent drag is reduced by more than 25%. This specific operation mode is more efficient when compared with steady driving, which is the present situation for virtually all fluid transport processes ranging from heating circuits to water, gas and oil pipelines.","lang":"eng"}],"pmid":1},{"file_date_updated":"2024-07-16T07:41:39Z","title":"Stress granules plug and stabilize damaged endolysosomal membranes","related_material":{"record":[{"status":"public","id":"14472","relation":"research_data"}],"link":[{"relation":"erratum","url":"https://doi.org/10.1038/s41586-023-06882-z"}]},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa":1,"citation":{"apa":"Bussi, C., Mangiarotti, A., Vanhille-Campos, C. E., Aylan, B., Pellegrino, E., Athanasiadi, N., … Gutierrez, M. G. (2023). Stress granules plug and stabilize damaged endolysosomal membranes. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-023-06726-w\">https://doi.org/10.1038/s41586-023-06726-w</a>","chicago":"Bussi, Claudio, Agustín Mangiarotti, Christian Eduardo Vanhille-Campos, Beren Aylan, Enrica Pellegrino, Natalia Athanasiadi, Antony Fearns, et al. “Stress Granules Plug and Stabilize Damaged Endolysosomal Membranes.” <i>Nature</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41586-023-06726-w\">https://doi.org/10.1038/s41586-023-06726-w</a>.","ama":"Bussi C, Mangiarotti A, Vanhille-Campos CE, et al. Stress granules plug and stabilize damaged endolysosomal membranes. <i>Nature</i>. 2023;623:1062-1069. doi:<a href=\"https://doi.org/10.1038/s41586-023-06726-w\">10.1038/s41586-023-06726-w</a>","ista":"Bussi C, Mangiarotti A, Vanhille-Campos CE, Aylan B, Pellegrino E, Athanasiadi N, Fearns A, Rodgers A, Franzmann TM, Šarić A, Dimova R, Gutierrez MG. 2023. Stress granules plug and stabilize damaged endolysosomal membranes. Nature. 623, 1062–1069.","ieee":"C. Bussi <i>et al.</i>, “Stress granules plug and stabilize damaged endolysosomal membranes,” <i>Nature</i>, vol. 623. Springer Nature, pp. 1062–1069, 2023.","short":"C. Bussi, A. Mangiarotti, C.E. Vanhille-Campos, B. Aylan, E. Pellegrino, N. Athanasiadi, A. Fearns, A. Rodgers, T.M. Franzmann, A. Šarić, R. Dimova, M.G. Gutierrez, Nature 623 (2023) 1062–1069.","mla":"Bussi, Claudio, et al. “Stress Granules Plug and Stabilize Damaged Endolysosomal Membranes.” <i>Nature</i>, vol. 623, Springer Nature, 2023, pp. 1062–69, doi:<a href=\"https://doi.org/10.1038/s41586-023-06726-w\">10.1038/s41586-023-06726-w</a>."},"date_created":"2023-11-27T07:56:37Z","year":"2023","quality_controlled":"1","article_type":"original","type":"journal_article","volume":623,"page":"1062-1069","day":"30","publication":"Nature","publisher":"Springer Nature","article_processing_charge":"Yes (via OA deal)","_id":"14610","abstract":[{"text":"Endomembrane damage represents a form of stress that is detrimental for eukaryotic cells<jats:sup>1,2</jats:sup>. To cope with this threat, cells possess mechanisms that repair the damage and restore cellular homeostasis<jats:sup>3–7</jats:sup>. Endomembrane damage also results in organelle instability and the mechanisms by which cells stabilize damaged endomembranes to enable membrane repair remains unknown. Here, by combining in vitro and in cellulo studies with computational modelling we uncover a biological function for stress granules whereby these biomolecular condensates form rapidly at endomembrane damage sites and act as a plug that stabilizes the ruptured membrane. Functionally, we demonstrate that stress granule formation and membrane stabilization enable efficient repair of damaged endolysosomes, through both ESCRT (endosomal sorting complex required for transport)-dependent and independent mechanisms. We also show that blocking stress granule formation in human macrophages creates a permissive environment for <jats:italic>Mycobacterium tuberculosis</jats:italic>, a human pathogen that exploits endomembrane damage to survive within the host.","lang":"eng"}],"intvolume":"       623","pmid":1,"status":"public","publication_status":"published","file":[{"access_level":"open_access","file_id":"17248","checksum":"b939a19e4c228fbf3beca298ac2ac014","file_size":17047711,"date_updated":"2024-07-16T07:41:39Z","success":1,"creator":"dernst","date_created":"2024-07-16T07:41:39Z","file_name":"2023_Nature_Bussi.pdf","relation":"main_file","content_type":"application/pdf"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"department":[{"_id":"AnSa"}],"isi":1,"publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"acknowledgement":"We thank the Human Embryonic Stem Cell Unit, Advanced Light Microscopy and High-throughput Screening facilities at the Crick for their support in various aspects of the work. We thank the laboratory of P. Anderson for providing the G3BP-DKO U2OS cells. The authors thank N. Chen for providing the purified glycinin protein; Z. Zhao for providing the microfluidic chip wafers; and M. Amaral and F. Frey for helpful discussions and valuable input regarding analysis methods. This work was supported by the Francis Crick Institute (to M.G.G.), which receives its core funding from Cancer Research UK (FC001092), the UK Medical Research Council (FC001092) and the Wellcome Trust (FC001092). This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 772022 to M.G.G.). C.B. has received funding from the European Respiratory Society and the European Union’s H2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 713406. A.M. acknowledges support from Alexander von Humboldt Foundation and C.V.-C. acknowledges funding by the Royal Society and the European Research Council under the European Union’s Horizon 2020 Research and Innovation Programme (grant no. 802960 to A.S.). All simulations were carried out on the high-performance computing cluster at the Institute of Science and Technology Austria. For the purpose of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.\r\nOpen Access funding provided by The Francis Crick Institute.","doi":"10.1038/s41586-023-06726-w","month":"11","oa_version":"Published Version","scopus_import":"1","has_accepted_license":"1","language":[{"iso":"eng"}],"external_id":{"pmid":["37968398"],"isi":["001105882300018"]},"date_updated":"2025-09-09T13:30:34Z","date_published":"2023-11-30T00:00:00Z","ddc":["570"],"author":[{"first_name":"Claudio","full_name":"Bussi, Claudio","last_name":"Bussi"},{"full_name":"Mangiarotti, Agustín","last_name":"Mangiarotti","first_name":"Agustín"},{"first_name":"Christian Eduardo","full_name":"Vanhille-Campos, Christian Eduardo","id":"3adeca52-9313-11ed-b1ac-c170b2505714","last_name":"Vanhille-Campos"},{"first_name":"Beren","last_name":"Aylan","full_name":"Aylan, Beren"},{"first_name":"Enrica","full_name":"Pellegrino, Enrica","last_name":"Pellegrino"},{"last_name":"Athanasiadi","full_name":"Athanasiadi, Natalia","first_name":"Natalia"},{"last_name":"Fearns","full_name":"Fearns, Antony","first_name":"Antony"},{"full_name":"Rodgers, Angela","last_name":"Rodgers","first_name":"Angela"},{"first_name":"Titus M.","last_name":"Franzmann","full_name":"Franzmann, Titus M."},{"orcid":"0000-0002-7854-2139","first_name":"Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","full_name":"Šarić, Anđela","last_name":"Šarić"},{"full_name":"Dimova, Rumiana","last_name":"Dimova","first_name":"Rumiana"},{"last_name":"Gutierrez","full_name":"Gutierrez, Maximiliano G.","first_name":"Maximiliano G."}]},{"day":"21","page":"495-499","volume":619,"type":"journal_article","article_processing_charge":"No","publisher":"Springer Nature","issue":"7970","extern":"1","publication":"Nature","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2210.10919","open_access":"1"}],"status":"public","_id":"18189","pmid":1,"abstract":[{"text":"Strongly interacting topological matter1 exhibits fundamentally new phenomena with potential applications in quantum information technology2,3. Emblematic instances are fractional quantum Hall (FQH) states4, in which the interplay of a magnetic field and strong interactions gives rise to fractionally charged quasi-particles, long-ranged entanglement and anyonic exchange statistics. Progress in engineering synthetic magnetic fields5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21 has raised the hope to create these exotic states in controlled quantum systems. However, except for a recent Laughlin state of light22, preparing FQH states in engineered systems remains elusive. Here we realize a FQH state with ultracold atoms in an optical lattice. The state is a lattice version of a bosonic ν = 1/2 Laughlin state4,23 with two particles on 16 sites. This minimal system already captures many hallmark features of Laughlin-type FQH states24,25,26,27,28: we observe a suppression of two-body interactions, we find a distinctive vortex structure in the density correlations and we measure a fractional Hall conductivity of σH/σ0 = 0.6(2) by means of the bulk response to a magnetic perturbation. Furthermore, by tuning the magnetic field, we map out the transition point between the normal and the FQH regime through a spectroscopic investigation of the many-body gap. Our work provides a starting point for exploring highly entangled topological matter with ultracold atoms29,30,31,32,33.","lang":"eng"}],"intvolume":"       619","publication_status":"published","arxiv":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Realization of a fractional quantum Hall state with ultracold atoms","citation":{"ama":"Leonard J, Kim S, Kwan J, et al. Realization of a fractional quantum Hall state with ultracold atoms. <i>Nature</i>. 2023;619(7970):495-499. doi:<a href=\"https://doi.org/10.1038/s41586-023-06122-4\">10.1038/s41586-023-06122-4</a>","ista":"Leonard J, Kim S, Kwan J, Segura P, Grusdt F, Repellin C, Goldman N, Greiner M. 2023. Realization of a fractional quantum Hall state with ultracold atoms. Nature. 619(7970), 495–499.","apa":"Leonard, J., Kim, S., Kwan, J., Segura, P., Grusdt, F., Repellin, C., … Greiner, M. (2023). Realization of a fractional quantum Hall state with ultracold atoms. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-023-06122-4\">https://doi.org/10.1038/s41586-023-06122-4</a>","chicago":"Leonard, Julian, Sooshin Kim, Joyce Kwan, Perrin Segura, Fabian Grusdt, Cécile Repellin, Nathan Goldman, and Markus Greiner. “Realization of a Fractional Quantum Hall State with Ultracold Atoms.” <i>Nature</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41586-023-06122-4\">https://doi.org/10.1038/s41586-023-06122-4</a>.","ieee":"J. Leonard <i>et al.</i>, “Realization of a fractional quantum Hall state with ultracold atoms,” <i>Nature</i>, vol. 619, no. 7970. Springer Nature, pp. 495–499, 2023.","mla":"Leonard, Julian, et al. “Realization of a Fractional Quantum Hall State with Ultracold Atoms.” <i>Nature</i>, vol. 619, no. 7970, Springer Nature, 2023, pp. 495–99, doi:<a href=\"https://doi.org/10.1038/s41586-023-06122-4\">10.1038/s41586-023-06122-4</a>.","short":"J. Leonard, S. Kim, J. Kwan, P. Segura, F. Grusdt, C. Repellin, N. Goldman, M. Greiner, Nature 619 (2023) 495–499."},"oa":1,"article_type":"original","quality_controlled":"1","year":"2023","date_created":"2024-10-07T11:46:13Z","scopus_import":"1","oa_version":"Preprint","month":"06","external_id":{"pmid":["37344594 "],"arxiv":["2210.10919"]},"language":[{"iso":"eng"}],"date_updated":"2024-10-08T11:09:24Z","author":[{"first_name":"Julian","id":"b75b3f45-7995-11ef-9bfd-9a9cd02c3577","full_name":"Leonard, Julian","last_name":"Leonard"},{"first_name":"Sooshin","full_name":"Kim, Sooshin","last_name":"Kim"},{"first_name":"Joyce","full_name":"Kwan, Joyce","last_name":"Kwan"},{"first_name":"Perrin","last_name":"Segura","full_name":"Segura, Perrin"},{"full_name":"Grusdt, Fabian","last_name":"Grusdt","first_name":"Fabian"},{"last_name":"Repellin","full_name":"Repellin, Cécile","first_name":"Cécile"},{"last_name":"Goldman","full_name":"Goldman, Nathan","first_name":"Nathan"},{"first_name":"Markus","full_name":"Greiner, Markus","last_name":"Greiner"}],"date_published":"2023-06-21T00:00:00Z","publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"doi":"10.1038/s41586-023-06122-4"},{"_id":"13096","pmid":1,"abstract":[{"lang":"eng","text":"Eukaryotic cells can undergo different forms of programmed cell death, many of which culminate in plasma membrane rupture as the defining terminal event1,2,3,4,5,6,7. Plasma membrane rupture was long thought to be driven by osmotic pressure, but it has recently been shown to be in many cases an active process, mediated by the protein ninjurin-18 (NINJ1). Here we resolve the structure of NINJ1 and the mechanism by which it ruptures membranes. Super-resolution microscopy reveals that NINJ1 clusters into structurally diverse assemblies in the membranes of dying cells, in particular large, filamentous assemblies with branched morphology. A cryo-electron microscopy structure of NINJ1 filaments shows a tightly packed fence-like array of transmembrane α-helices. Filament directionality and stability is defined by two amphipathic α-helices that interlink adjacent filament subunits. The NINJ1 filament features a hydrophilic side and a hydrophobic side, and molecular dynamics simulations show that it can stably cap membrane edges. The function of the resulting supramolecular arrangement was validated by site-directed mutagenesis. Our data thus suggest that, during lytic cell death, the extracellular α-helices of NINJ1 insert into the plasma membrane to polymerize NINJ1 monomers into amphipathic filaments that rupture the plasma membrane. The membrane protein NINJ1 is therefore an interactive component of the eukaryotic cell membrane that functions as an in-built breaking point in response to activation of cell death."}],"intvolume":"       618","status":"public","publication_status":"published","file":[{"access_level":"open_access","file_id":"14533","checksum":"0fab69252453bff1de7f0e2eceb76d34","file_size":12292188,"date_updated":"2023-11-14T11:48:18Z","creator":"dernst","success":1,"date_created":"2023-11-14T11:48:18Z","file_name":"2023_Nature_Degen.pdf","relation":"main_file","content_type":"application/pdf"}],"type":"journal_article","volume":618,"day":"29","page":"1065-1071","publication":"Nature","publisher":"Springer Nature","article_processing_charge":"Yes (via OA deal)","oa":1,"citation":{"ama":"Degen M, Santos JC, Pluhackova K, et al. Structural basis of NINJ1-mediated plasma membrane rupture in cell death. <i>Nature</i>. 2023;618:1065-1071. doi:<a href=\"https://doi.org/10.1038/s41586-023-05991-z\">10.1038/s41586-023-05991-z</a>","ista":"Degen M, Santos JC, Pluhackova K, Cebrero G, Ramos S, Jankevicius G, Hartenian E, Guillerm U, Mari SA, Kohl B, Müller DJ, Schanda P, Maier T, Perez C, Sieben C, Broz P, Hiller S. 2023. Structural basis of NINJ1-mediated plasma membrane rupture in cell death. Nature. 618, 1065–1071.","apa":"Degen, M., Santos, J. C., Pluhackova, K., Cebrero, G., Ramos, S., Jankevicius, G., … Hiller, S. (2023). Structural basis of NINJ1-mediated plasma membrane rupture in cell death. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-023-05991-z\">https://doi.org/10.1038/s41586-023-05991-z</a>","chicago":"Degen, Morris, José Carlos Santos, Kristyna Pluhackova, Gonzalo Cebrero, Saray Ramos, Gytis Jankevicius, Ella Hartenian, et al. “Structural Basis of NINJ1-Mediated Plasma Membrane Rupture in Cell Death.” <i>Nature</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41586-023-05991-z\">https://doi.org/10.1038/s41586-023-05991-z</a>.","short":"M. Degen, J.C. Santos, K. Pluhackova, G. Cebrero, S. Ramos, G. Jankevicius, E. Hartenian, U. Guillerm, S.A. Mari, B. Kohl, D.J. Müller, P. Schanda, T. Maier, C. Perez, C. Sieben, P. Broz, S. Hiller, Nature 618 (2023) 1065–1071.","ieee":"M. Degen <i>et al.</i>, “Structural basis of NINJ1-mediated plasma membrane rupture in cell death,” <i>Nature</i>, vol. 618. Springer Nature, pp. 1065–1071, 2023.","mla":"Degen, Morris, et al. “Structural Basis of NINJ1-Mediated Plasma Membrane Rupture in Cell Death.” <i>Nature</i>, vol. 618, Springer Nature, 2023, pp. 1065–71, doi:<a href=\"https://doi.org/10.1038/s41586-023-05991-z\">10.1038/s41586-023-05991-z</a>."},"date_created":"2023-05-28T22:01:04Z","year":"2023","quality_controlled":"1","article_type":"original","file_date_updated":"2023-11-14T11:48:18Z","title":"Structural basis of NINJ1-mediated plasma membrane rupture in cell death","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2025-04-23T08:57:12Z","date_published":"2023-06-29T00:00:00Z","ddc":["570"],"author":[{"first_name":"Morris","full_name":"Degen, Morris","last_name":"Degen"},{"first_name":"José Carlos","full_name":"Santos, José Carlos","last_name":"Santos"},{"first_name":"Kristyna","full_name":"Pluhackova, Kristyna","last_name":"Pluhackova"},{"full_name":"Cebrero, Gonzalo","last_name":"Cebrero","first_name":"Gonzalo"},{"last_name":"Ramos","full_name":"Ramos, Saray","first_name":"Saray"},{"last_name":"Jankevicius","full_name":"Jankevicius, Gytis","first_name":"Gytis"},{"first_name":"Ella","last_name":"Hartenian","full_name":"Hartenian, Ella"},{"last_name":"Guillerm","full_name":"Guillerm, Undina","id":"bb74f472-ae54-11eb-9835-bc9c22fb1183","first_name":"Undina"},{"last_name":"Mari","full_name":"Mari, Stefania A.","first_name":"Stefania A."},{"full_name":"Kohl, Bastian","last_name":"Kohl","first_name":"Bastian"},{"first_name":"Daniel J.","full_name":"Müller, Daniel J.","last_name":"Müller"},{"first_name":"Paul","orcid":"0000-0002-9350-7606","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","full_name":"Schanda, Paul","last_name":"Schanda"},{"first_name":"Timm","last_name":"Maier","full_name":"Maier, Timm"},{"first_name":"Camilo","full_name":"Perez, Camilo","last_name":"Perez"},{"first_name":"Christian","full_name":"Sieben, Christian","last_name":"Sieben"},{"full_name":"Broz, Petr","last_name":"Broz","first_name":"Petr"},{"first_name":"Sebastian","last_name":"Hiller","full_name":"Hiller, Sebastian"}],"month":"06","scopus_import":"1","oa_version":"Published Version","has_accepted_license":"1","language":[{"iso":"eng"}],"acknowledged_ssus":[{"_id":"NMR"},{"_id":"LifeSc"}],"external_id":{"isi":["000991386800011"],"pmid":["37198476"]},"publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"acknowledgement":"This work was supported by the Deutsche Forschungsgemeinschaft under Germany’s Excellence Strategy EXC 2075–390740016 and the Stuttgart Center for Simulation Science (SC SimTech) to K.P., by ERC-CoG 770988 (InflamCellDeath) and SNF Project funding (310030B_198005, 310030B_192523) to P.B., by the Swiss Nanoscience Institute and the Swiss National Science Foundation via the NCCR AntiResist (180541) to S.H. and the NCCR Molecular Systems Engineering (51NF40-205608) to D.J.M., by the Helmholtz Young Investigator Program of the Helmholtz Association to C.S., by the SNF Professorship funding (PP00P3_198903) to C.P., EMBO postdoctoral fellowship ALTF 27-2022 to E.H. and by the Scientific Service Units of IST Austria through resources provided by the NMR and Life Science Facilities to P.S. Molecular dynamics simulations were performed on the HoreKa supercomputer funded by the Ministry of Science, Research and the Arts Baden-Württemberg and by the Federal Ministry of Education and Research. The authors thank the BioEM Lab of the Biozentrum, University of Basel for support; V. Mack, K. Shkarina and J. Fricke for technical support; D. Ricklin and S. Vogt for peptide synthesis; P. Pelczar for support with animals; S.-J. Marrink and P. Telles de Souza for supply with Martini3 parameters and scripts; and P. Radler und M. Loose for help with QCM. Fig. 4g and Extended Data Fig. 1a were in part created with BioRender.com.\r\nOpen access funding provided by University of Basel.","doi":"10.1038/s41586-023-05991-z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"isi":1,"department":[{"_id":"PaSc"}]},{"status":"public","intvolume":"       618","_id":"13119","abstract":[{"lang":"eng","text":"A density wave (DW) is a fundamental type of long-range order in quantum matter tied to self-organization into a crystalline structure. The interplay of DW order with superfluidity can lead to complex scenarios that pose a great challenge to theoretical analysis. In the past decades, tunable quantum Fermi gases have served as model systems for exploring the physics of strongly interacting fermions, including most notably magnetic ordering1, pairing and superfluidity2, and the crossover from a Bardeen–Cooper–Schrieffer superfluid to a Bose–Einstein condensate3. Here, we realize a Fermi gas featuring both strong, tunable contact interactions and photon-mediated, spatially structured long-range interactions in a transversely driven high-finesse optical cavity. Above a critical long-range interaction strength, DW order is stabilized in the system, which we identify via its superradiant light-scattering properties. We quantitatively measure the variation of the onset of DW order as the contact interaction is varied across the Bardeen–Cooper–Schrieffer superfluid and Bose–Einstein condensate crossover, in qualitative agreement with a mean-field theory. The atomic DW susceptibility varies over an order of magnitude upon tuning the strength and the sign of the long-range interactions below the self-ordering threshold, demonstrating independent and simultaneous control over the contact and long-range interactions. Therefore, our experimental setup provides a fully tunable and microscopically controllable platform for the experimental study of the interplay of superfluidity and DW order."}],"pmid":1,"file":[{"file_name":"2023_Nature_Helson.pdf","date_created":"2023-11-14T13:00:19Z","relation":"main_file","content_type":"application/pdf","date_updated":"2023-11-14T13:00:19Z","success":1,"creator":"dernst","checksum":"4887a296e3b6f54e8c0b946cbfd24f49","file_size":8156497,"access_level":"open_access","file_id":"14534"}],"publication_status":"published","type":"journal_article","day":"22","page":"716-720","volume":618,"publisher":"Springer Nature","publication":"Nature","article_processing_charge":"Yes (via OA deal)","oa":1,"citation":{"mla":"Helson, Victor, et al. “Density-Wave Ordering in a Unitary Fermi Gas with Photon-Mediated Interactions.” <i>Nature</i>, vol. 618, Springer Nature, 2023, pp. 716–20, doi:<a href=\"https://doi.org/10.1038/s41586-023-06018-3\">10.1038/s41586-023-06018-3</a>.","ieee":"V. Helson <i>et al.</i>, “Density-wave ordering in a unitary Fermi gas with photon-mediated interactions,” <i>Nature</i>, vol. 618. Springer Nature, pp. 716–720, 2023.","short":"V. Helson, T. Zwettler, F. Mivehvar, E. Colella, K.E.R. Roux, H. Konishi, H. Ritsch, J.P. Brantut, Nature 618 (2023) 716–720.","ista":"Helson V, Zwettler T, Mivehvar F, Colella E, Roux KER, Konishi H, Ritsch H, Brantut JP. 2023. Density-wave ordering in a unitary Fermi gas with photon-mediated interactions. Nature. 618, 716–720.","ama":"Helson V, Zwettler T, Mivehvar F, et al. Density-wave ordering in a unitary Fermi gas with photon-mediated interactions. <i>Nature</i>. 2023;618:716-720. doi:<a href=\"https://doi.org/10.1038/s41586-023-06018-3\">10.1038/s41586-023-06018-3</a>","chicago":"Helson, Victor, Timo Zwettler, Farokh Mivehvar, Elvia Colella, Kevin Etienne Robert Roux, Hideki Konishi, Helmut Ritsch, and Jean Philippe Brantut. “Density-Wave Ordering in a Unitary Fermi Gas with Photon-Mediated Interactions.” <i>Nature</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41586-023-06018-3\">https://doi.org/10.1038/s41586-023-06018-3</a>.","apa":"Helson, V., Zwettler, T., Mivehvar, F., Colella, E., Roux, K. E. R., Konishi, H., … Brantut, J. P. (2023). Density-wave ordering in a unitary Fermi gas with photon-mediated interactions. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-023-06018-3\">https://doi.org/10.1038/s41586-023-06018-3</a>"},"year":"2023","date_created":"2023-06-04T22:01:03Z","article_type":"original","quality_controlled":"1","title":"Density-wave ordering in a unitary Fermi gas with photon-mediated interactions","file_date_updated":"2023-11-14T13:00:19Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2025-04-23T08:58:21Z","ddc":["530"],"date_published":"2023-06-22T00:00:00Z","author":[{"first_name":"Victor","full_name":"Helson, Victor","last_name":"Helson"},{"full_name":"Zwettler, Timo","last_name":"Zwettler","first_name":"Timo"},{"last_name":"Mivehvar","full_name":"Mivehvar, Farokh","first_name":"Farokh"},{"first_name":"Elvia","last_name":"Colella","full_name":"Colella, Elvia"},{"full_name":"Roux, Kevin Etienne Robert","last_name":"Roux","id":"53f93ea2-803f-11ed-ab7e-b283135794ef","first_name":"Kevin Etienne Robert"},{"last_name":"Konishi","full_name":"Konishi, Hideki","first_name":"Hideki"},{"last_name":"Ritsch","full_name":"Ritsch, Helmut","first_name":"Helmut"},{"last_name":"Brantut","full_name":"Brantut, Jean Philippe","first_name":"Jean Philippe"}],"month":"06","has_accepted_license":"1","scopus_import":"1","oa_version":"Published Version","language":[{"iso":"eng"}],"external_id":{"pmid":["37225993"],"isi":["001001139300008"]},"publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"acknowledgement":"Open access funding provided by EPFL Lausanne.We acknowledge discussions with T. Donner and T. Esslinger. We thank G. del Pace and T. Bühler for their assistance in the final stages of the experiment. We acknowledge funding from the European Research Council under the European Union Horizon 2020 Research and Innovation Programme (Grant no. 714309) and the Swiss National Science Foundation (Grant no. 184654). F.M. acknowledges financial support from the Austrian Science Fund (Stand-Alone Project P 35891-N).","doi":"10.1038/s41586-023-06018-3","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"department":[{"_id":"GeKa"}],"isi":1}]