---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21485'
abstract:
- lang: eng
text: Insulating oxides are among the most abundant solid materials in the universe1,2,3.
Of the many ways in which they influence natural phenomena, perhaps the most consequential
is their capacity to transfer electrical charge during contact4,5,6,7,8,9,10—which
occurs even between samples of the same oxide—yet the symmetry-breaking parameter
that causes this remains unidentified11,12. Here we show that adventitious carbonaceous
molecules adsorbed from the environment are the symmetry-breaking factor in same-material
oxide contact electrification (CE). We use acoustic levitation to measure charge
exchange between a sphere and a plate composed of identical amorphous silicon
dioxide (SiO2). Although charging polarity is random for co-prepared samples,
we control it with baking or plasma treatment. Observing the charge-exchange relaxation
afterwards, we see dynamics over a timescale of hours and connect this directly
to the presence of adventitious carbon with time-of-flight mass spectrometry,
low-energy ion scattering and infrared spectroscopy. Going further, we confirm
that adventitious carbon can even determine charge exchange among different oxides.
Our results identify the symmetry-breaking parameter that causes insulating oxides
to exchange charge in settings ranging from desert sands4 to volcanic plumes5,6,
while simultaneously highlighting an overlooked factor in CE more broadly.
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
- _id: ScienComp
- _id: LifeSc
acknowledgement: This project has received support from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme
(grant agreement no. 949120) and from the Marie Skłodowska-Curie programme (grant
agreement no. 754411). We acknowledge the state of Lower Austria and the European
Regional Development Fund under grant no. WST3-F-542638/004-2021. N.M. acknowledges
support from grant Fondecyt 1221597. G.G. is a Serra Húnter fellow. This research
was supported by the Scientific Service Units of the Institute of Science and Technology
Austria through resources provided by the Miba Machine Shop, Nanofabrication Facility,
Scientific Computing facility and Lab Support Facility. We thank the Modic group
for the use of the Laue camera, T. Zauner for the photography of the experimental
set-up and R. Möller for insightful discussions. Open access funding provided by
Institute of Science and Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Galien M
full_name: Grosjean, Galien M
id: 0C5FDA4A-9CF6-11E9-8939-FF05E6697425
last_name: Grosjean
orcid: 0000-0001-5154-417X
- first_name: Markus
full_name: Ostermann, Markus
last_name: Ostermann
- first_name: Markus
full_name: Sauer, Markus
last_name: Sauer
- first_name: Michael
full_name: Hahn, Michael
last_name: Hahn
- first_name: Christian M.
full_name: Pichler, Christian M.
last_name: Pichler
- first_name: Florian
full_name: Fahrnberger, Florian
last_name: Fahrnberger
- first_name: Felix
full_name: Pertl, Felix
id: 6313aec0-15b2-11ec-abd3-ed67d16139af
last_name: Pertl
orcid: 0000-0003-0463-5794
- first_name: Daniel
full_name: Balazs, Daniel
id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E
last_name: Balazs
orcid: 0000-0001-7597-043X
- first_name: Mason M.
full_name: Link, Mason M.
last_name: Link
- first_name: Seong H.
full_name: Kim, Seong H.
last_name: Kim
- first_name: Devin L.
full_name: Schrader, Devin L.
last_name: Schrader
- first_name: Adriana
full_name: Blanco, Adriana
last_name: Blanco
- first_name: Francisco
full_name: Gracia, Francisco
last_name: Gracia
- first_name: Nicolás
full_name: Mujica, Nicolás
last_name: Mujica
- first_name: Scott R
full_name: Waitukaitis, Scott R
id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87
last_name: Waitukaitis
orcid: 0000-0002-2299-3176
citation:
ama: Grosjean GM, Ostermann M, Sauer M, et al. Adventitious carbon breaks symmetry
in oxide contact electrification. Nature. 2026;651(8106):626-631. doi:10.1038/s41586-025-10088-w
apa: Grosjean, G. M., Ostermann, M., Sauer, M., Hahn, M., Pichler, C. M., Fahrnberger,
F., … Waitukaitis, S. R. (2026). Adventitious carbon breaks symmetry in oxide
contact electrification. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-10088-w
chicago: Grosjean, Galien M, Markus Ostermann, Markus Sauer, Michael Hahn, Christian
M. Pichler, Florian Fahrnberger, Felix Pertl, et al. “Adventitious Carbon Breaks
Symmetry in Oxide Contact Electrification.” Nature. Springer Nature, 2026.
https://doi.org/10.1038/s41586-025-10088-w.
ieee: G. M. Grosjean et al., “Adventitious carbon breaks symmetry in oxide
contact electrification,” Nature, vol. 651, no. 8106. Springer Nature,
pp. 626–631, 2026.
ista: Grosjean GM, Ostermann M, Sauer M, Hahn M, Pichler CM, Fahrnberger F, Pertl
F, Balazs D, Link MM, Kim SH, Schrader DL, Blanco A, Gracia F, Mujica N, Waitukaitis
SR. 2026. Adventitious carbon breaks symmetry in oxide contact electrification.
Nature. 651(8106), 626–631.
mla: Grosjean, Galien M., et al. “Adventitious Carbon Breaks Symmetry in Oxide Contact
Electrification.” Nature, vol. 651, no. 8106, Springer Nature, 2026, pp.
626–31, doi:10.1038/s41586-025-10088-w.
short: G.M. Grosjean, M. Ostermann, M. Sauer, M. Hahn, C.M. Pichler, F. Fahrnberger,
F. Pertl, D. Balazs, M.M. Link, S.H. Kim, D.L. Schrader, A. Blanco, F. Gracia,
N. Mujica, S.R. Waitukaitis, Nature 651 (2026) 626–631.
corr_author: '1'
date_created: 2026-03-23T15:04:00Z
date_published: 2026-03-18T00:00:00Z
date_updated: 2026-04-28T12:06:01Z
day: '18'
ddc:
- '540'
department:
- _id: ScWa
- _id: GradSch
- _id: LifeSc
doi: 10.1038/s41586-025-10088-w
ec_funded: 1
external_id:
pmid:
- '41851325'
file:
- access_level: open_access
checksum: dafef9ed575b44be4263e948a47ae056
content_type: application/pdf
creator: dernst
date_created: 2026-03-24T06:57:08Z
date_updated: 2026-03-24T06:57:08Z
file_id: '21494'
file_name: 2026_Nature_Grosjean.pdf
file_size: 12245694
relation: main_file
success: 1
file_date_updated: 2026-03-24T06:57:08Z
fulldoi: https://doi.org/10.1038/s41586-025-10088-w
has_accepted_license: '1'
intvolume: ' 651'
issue: '8106'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 626-631
pmid: 1
project:
- _id: 0aa60e99-070f-11eb-9043-a6de6bdc3afa
call_identifier: H2020
grant_number: '949120'
name: 'Tribocharge: a multi-scale approach to an enduring problem in physics'
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/colliding-dust-and-the-sparks-of-creation/
status: public
title: Adventitious carbon breaks symmetry in oxide contact electrification
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 651
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21798'
abstract:
- lang: eng
text: 'Phase singularities—points carrying quantized topological charge—are universal
features found across diverse wave systems from superfluids and superconductors
to acoustic and optical fields1,2,3,4. Ensembles of these singularities exhibit
distance correlations resembling particles in liquids5,6,7,8, extensively studied
for their role in exotic material phases9,10,11. By contrast, the full correlations
in phase space that govern the system evolution have remained unexplored and experimentally
inaccessible. Here we directly measure the ultrafast dynamics of optical singularity
ensembles, capturing their full phase-space correlations, presenting the joint
distance–velocity distribution. Our observations show a breakdown of the particle-singularity
analogy12: phase singularities accelerate towards formally divergent velocities
in the moment before annihilation7,13,14, indicated by measurements of velocities
exceeding the speed of light. These apparent superluminal velocities are paradoxically
amplified by the slow group velocity of hyperbolic phonon polaritons in our material
platform, hexagonal boron nitride membranes15,16,17,18,19. We demonstrate these
phenomena using combined hardware and algorithmic advances in ultrafast electron
microscopy18,20,21,22,23,24,25, achieving spatial and temporal resolutions, each
an order of magnitude below the polaritonic wavelength and cycle period. Our findings
deepen our understanding of phase singularities and their universality, enabling
to probe topological defect dynamics at previously unattainable timescales.'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: T.
full_name: Bucher, T.
last_name: Bucher
- first_name: A.
full_name: Gorlach, A.
last_name: Gorlach
- first_name: A.
full_name: Niedermayr, A.
last_name: Niedermayr
- first_name: Q.
full_name: Yan, Q.
last_name: Yan
- first_name: H.
full_name: Nahari, H.
last_name: Nahari
- first_name: K.
full_name: Wang, K.
last_name: Wang
- first_name: R.
full_name: Ruimy, R.
last_name: Ruimy
- first_name: Y.
full_name: Adiv, Y.
last_name: Adiv
- first_name: M.
full_name: Yannai, M.
last_name: Yannai
- first_name: T. L.
full_name: Abudi, T. L.
last_name: Abudi
- first_name: E.
full_name: Janzen, E.
last_name: Janzen
- first_name: C.
full_name: Spaegele, C.
last_name: Spaegele
- first_name: Charles
full_name: Roques-Carmes, Charles
id: e2e68fc9-6505-11ef-a541-eb4e72cc3e82
last_name: Roques-Carmes
- first_name: J. H.
full_name: Edgar, J. H.
last_name: Edgar
- first_name: F. H. L.
full_name: Koppens, F. H. L.
last_name: Koppens
- first_name: G. M.
full_name: Vanacore, G. M.
last_name: Vanacore
- first_name: H.
full_name: H. Sheinfux, H.
last_name: H. Sheinfux
- first_name: S.
full_name: Tsesses, S.
last_name: Tsesses
- first_name: I.
full_name: Kaminer, I.
last_name: Kaminer
citation:
ama: Bucher T, Gorlach A, Niedermayr A, et al. Superluminal correlations in ensembles
of optical phase singularities. Nature. 2026;651(8107):920-926. doi:10.1038/s41586-026-10209-z
apa: Bucher, T., Gorlach, A., Niedermayr, A., Yan, Q., Nahari, H., Wang, K., … Kaminer,
I. (2026). Superluminal correlations in ensembles of optical phase singularities.
Nature. Springer Nature. https://doi.org/10.1038/s41586-026-10209-z
chicago: Bucher, T., A. Gorlach, A. Niedermayr, Q. Yan, H. Nahari, K. Wang, R. Ruimy,
et al. “Superluminal Correlations in Ensembles of Optical Phase Singularities.”
Nature. Springer Nature, 2026. https://doi.org/10.1038/s41586-026-10209-z.
ieee: T. Bucher et al., “Superluminal correlations in ensembles of optical
phase singularities,” Nature, vol. 651, no. 8107. Springer Nature, pp.
920–926, 2026.
ista: Bucher T, Gorlach A, Niedermayr A, Yan Q, Nahari H, Wang K, Ruimy R, Adiv
Y, Yannai M, Abudi TL, Janzen E, Spaegele C, Roques-Carmes C, Edgar JH, Koppens
FHL, Vanacore GM, H. Sheinfux H, Tsesses S, Kaminer I. 2026. Superluminal correlations
in ensembles of optical phase singularities. Nature. 651(8107), 920–926.
mla: Bucher, T., et al. “Superluminal Correlations in Ensembles of Optical Phase
Singularities.” Nature, vol. 651, no. 8107, Springer Nature, 2026, pp.
920–26, doi:10.1038/s41586-026-10209-z.
short: T. Bucher, A. Gorlach, A. Niedermayr, Q. Yan, H. Nahari, K. Wang, R. Ruimy,
Y. Adiv, M. Yannai, T.L. Abudi, E. Janzen, C. Spaegele, C. Roques-Carmes, J.H.
Edgar, F.H.L. Koppens, G.M. Vanacore, H. H. Sheinfux, S. Tsesses, I. Kaminer,
Nature 651 (2026) 920–926.
date_created: 2026-05-05T11:05:31Z
date_published: 2026-03-25T00:00:00Z
date_updated: 2026-05-05T11:10:07Z
day: '25'
doi: 10.1038/s41586-026-10209-z
extern: '1'
external_id:
arxiv:
- '2509.17675'
fulldoi: https://doi.org/10.1038/s41586-026-10209-z
intvolume: ' 651'
issue: '8107'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2509.17675
month: '03'
oa: 1
oa_version: Preprint
page: 920-926
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Superluminal correlations in ensembles of optical phase singularities
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 651
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22372'
abstract:
- lang: eng
text: Neurons acquire polarity by specifying one neurite as the axon, whereas the
others become dendrites. But how this fundamental asymmetry is established remains
unclear1. Neuronal polarization has been thought to rely primarily on growth cones
that sense external cues2. Here we show that growth cones alone do not direct
this process and that the soma acts as a central organizer of neuronal polarization.
Using live imaging and genetic loss-of-function approaches in vivo, combined with
optogenetic control and local cytoskeletal perturbations in cultured neurons,
we uncover a soma-initiated oscillatory program that primes axon selection. Periodic
actin branching that depends on the actin-related protein 2/3 (ARP2/3) complex
at the soma remodels a global actomyosin network, thereby generating an actin
wave that retracts neurites before propagating into a single neurite tip. Exposure
to this wave relaxes local actomyosin contractility, which drives a transient
microtubule-based protrusion and biases this neurite towards axon fate. As the
cell exits this oscillatory stage, this neurite can overcome global inhibition
and extend independently of ARP2/3, whereas actomyosin activity suppresses axon
formation in the remaining neurites so that they subsequently become dendrites.
This soma-driven mechanism ensures the emergence of a single axon independent
of environmental cues and underpins the unidirectional information flow in neuronal
circuits.
acknowledgement: 'We thank O. Gruss, E. Handley, H. Herzel, A. Kania, A. Koseska,
E. Kiermaier, D. Manstein, C. Niessen, K. Rottner, J. Schiweck, G. Tavosanis, D. Wachten,
R. Wedlich-Söldner and W. Witke for critically reading and discussing the manuscript;
C. Günter and V. Štimac for feedback on data presentation; B. Randel, J. Benner,
L. Meyn and A.-T. Pham for technical assistance; L. M. Neußer, K. Herz, K. Van-De-Kamp
and M. Diwo for their support on mice maintenance; H. Fried, I. Koenig, S. Filser
and Y. Fu for their technical support on experimental setup; and M. Aghabeig for
writing the Fiji macro scripts. C.H.C. was a Human Frontier Science Program Long-term
Postdoctoral Fellow (LT000100/2013). F.B. is supported by the Deutsches Zentrum
für Neurodegenerative Erkrankungen (DZNE), the International Foundation for Research
in Paraplegia, Wings for Life, ERANET AXON REPAIR, ERANET RATER SCI and the Chan–Zuckerberg
Initiative (CZI). F.B. is also funded by the Deutsche Forschungsgemeinschaft (DFG,
German Research Foundation)–Project-ID 227953431–SFB 1089, SFB 1690 as well as SFB
1158 and SPP 2395. F.B. is a member of the excellence cluster ImmunoSensation2 (EXC2151–390873048)
and the iBehave NRW network. F.B. is a recipient of the Roger de Spoelberch Prize.
F.K.M.S. acknowledges support from Austrian Science Fund (FWF): P33367. A.N. is
supported by JSPS KAKENHI (grant numbers 18H02410 and 21H02440). Open access funding
provided by Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) in
der Helmholtz-Gemeinschaft.'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Tien Chen
full_name: Lin, Tien Chen
last_name: Lin
- first_name: Charlotte H.
full_name: Coles, Charlotte H.
last_name: Coles
- first_name: Eissa
full_name: Alfadil, Eissa
last_name: Alfadil
- first_name: Florian
full_name: Fäßler, Florian
id: 404F5528-F248-11E8-B48F-1D18A9856A87
last_name: Fäßler
orcid: 0000-0001-7149-769X
- first_name: Andreas
full_name: Husch, Andreas
last_name: Husch
- first_name: Sebastian
full_name: Dupraz, Sebastian
last_name: Dupraz
- first_name: Thorben
full_name: Pietralla, Thorben
last_name: Pietralla
- first_name: Akihiro
full_name: Narita, Akihiro
last_name: Narita
- first_name: Max
full_name: Schelski, Max
last_name: Schelski
- first_name: Kevin C.
full_name: Flynn, Kevin C.
last_name: Flynn
- first_name: Sina
full_name: Stern, Sina
last_name: Stern
- first_name: Christoph
full_name: Möhl, Christoph
last_name: Möhl
- first_name: Brett J.
full_name: Hilton, Brett J.
last_name: Hilton
- first_name: Franz
full_name: Vauti, Franz
last_name: Vauti
- first_name: Hans Henning
full_name: Arnold, Hans Henning
last_name: Arnold
- first_name: Florian Km
full_name: Schur, Florian Km
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
- first_name: Frank
full_name: Bradke, Frank
last_name: Bradke
citation:
ama: Lin TC, Coles CH, Alfadil E, et al. An intrinsic cytoskeletal oscillator establishes
neuronal polarity. Nature. 2026. doi:10.1038/s41586-026-10755-6
apa: Lin, T. C., Coles, C. H., Alfadil, E., Fäßler, F., Husch, A., Dupraz, S., …
Bradke, F. (2026). An intrinsic cytoskeletal oscillator establishes neuronal polarity.
Nature. Springer Nature. https://doi.org/10.1038/s41586-026-10755-6
chicago: Lin, Tien Chen, Charlotte H. Coles, Eissa Alfadil, Florian Fäßler, Andreas
Husch, Sebastian Dupraz, Thorben Pietralla, et al. “An Intrinsic Cytoskeletal
Oscillator Establishes Neuronal Polarity.” Nature. Springer Nature, 2026.
https://doi.org/10.1038/s41586-026-10755-6.
ieee: T. C. Lin et al., “An intrinsic cytoskeletal oscillator establishes
neuronal polarity,” Nature. Springer Nature, 2026.
ista: Lin TC, Coles CH, Alfadil E, Fäßler F, Husch A, Dupraz S, Pietralla T, Narita
A, Schelski M, Flynn KC, Stern S, Möhl C, Hilton BJ, Vauti F, Arnold HH, Schur
FK, Bradke F. 2026. An intrinsic cytoskeletal oscillator establishes neuronal
polarity. Nature.
mla: Lin, Tien Chen, et al. “An Intrinsic Cytoskeletal Oscillator Establishes Neuronal
Polarity.” Nature, Springer Nature, 2026, doi:10.1038/s41586-026-10755-6.
short: T.C. Lin, C.H. Coles, E. Alfadil, F. Fäßler, A. Husch, S. Dupraz, T. Pietralla,
A. Narita, M. Schelski, K.C. Flynn, S. Stern, C. Möhl, B.J. Hilton, F. Vauti,
H.H. Arnold, F.K. Schur, F. Bradke, Nature (2026).
das_tickbox: '1'
dataavailabilitystatement: The raw data of the representative images have been deposited
into Zenodo (https://doi.org/10.5281/zenodo.20118606)99. Owing to the large file
size of the raw image data and the processed data used in the analyses that generated
the graphs, we archived the image files in the read-only file archive at the DZNE
institute. We provide raw data files upon request. The request can be directed to
and will be fulfilled by the lead contact F.B. Source data are provided with this
paper. The custom ImageJ macro used for generating kymographs, extracting neurite
tip positions and protein intensities is available at GitHub (https://github.com/darkbreaker0/IJ_NeuriteGrowthScript)
and Zenodo (https://doi.org/10.5281/zenodo.20118606)99. The custom R and Python
scripts used in the study are available at GitHub (https://github.com/darkbreaker0/Arp3_neuronal_polarization_2026)
and Zenodo (https://doi.org/10.5281/zenodo.20118606)99. The code used for polarity
determination of the actin filament in tomograms is available at Zenodo (https://doi.org/10.5281/zenodo.20081075)93.
date_created: 2026-07-19T22:01:48Z
date_published: 2026-07-08T00:00:00Z
date_updated: 2026-07-20T14:18:10Z
day: '08'
ddc:
- '570'
department:
- _id: FlSc
doi: 10.1038/s41586-026-10755-6
external_id:
pmid:
- '42420447'
fulldoi: https://doi.org/10.1038/s41586-026-10755-6
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41586-026-10755-6
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 9B954C5C-BA93-11EA-9121-9846C619BF3A
grant_number: P33367
name: Structure and isoform diversity of the Arp2/3 complex
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: An intrinsic cytoskeletal oscillator establishes neuronal polarity
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20963'
abstract:
- lang: eng
text: In all domains of life, tRNAs mediate the transfer of genetic information
from mRNAs to proteins. As their depletion suppresses translation and, consequently,
viral replication, tRNAs represent long-standing and increasingly recognized targets
of innate immunity1,2,3,4,5. Here we report Cas12a3 effector nucleases from type V
CRISPR–Cas adaptive immune systems in bacteria that preferentially cleave tRNAs
after recognition of target RNA. Cas12a3 orthologues belong to one of two previously
unreported nuclease clades that exhibit RNA-mediated cleavage of non-target RNA,
and are distinct from all other known type V systems. Through cell-based and biochemical
assays and direct RNA sequencing, we demonstrate that recognition of a complementary
target RNA by the CRISPR RNA triggers Cas12a3 to cleave the conserved 5′-CCA-3′
tail of diverse tRNAs to drive growth arrest and anti-phage defence. Cryogenic
electron microscopy structures further revealed a distinct tRNA-loading domain
that positions the tRNA tail in the RuvC active site of the nuclease. By designing
synthetic reporters that mimic the tRNA acceptor stem and tail, we expanded the
capacity of current CRISPR-based diagnostics for multiplexed RNA detection. Overall,
these findings reveal widespread tRNA inactivation as a previously unrecognized
CRISPR-based immune strategy that broadens the application space of the existing
CRISPR toolbox.
acknowledgement: 'We thank Ł. Koziej for processing of the initial cryo-EM datasets,
S. Schmelz for support in cryo-EM, A. Gatzemeier for assistance in the purification
of dBa1Cas12a3, R. Rarose for support with the in vitro RNA experiments, M. Kaminski
for providing purified PsmCas13b protein, L. Schönemann for protein purification,
and C. Krempl and S. Backesfor providing the RSV and influenza A transcript-encoding
plasmids. This work was supported through funding by the European Research Council
(101001394 to S.G.; 865973 and 101158249 to C.L.B.), the R. Gaurth Hansen Family
(to R.N.J.), the National Institutes of Health (R35GM138080 to R.N.J.), the PostDoc
Plus Program from the Graduate School of Life Sciences at Julius-Maximilians-Universität
Würzburg (to O.D.), and the Deutsche Forschungsgemeinschaft (DFG, German Research
Foundation) under Germany’s Excellence Strategy–The Berlin Mathematics Research
Center MATH+ (EXC−2046/1, project ID: 390685689 to M.v.K.). Open access funding
provided by Helmholtz-Zentrum für Infektionsforschung GmbH (HZI).'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Oleg
full_name: Dmytrenko, Oleg
last_name: Dmytrenko
- first_name: Biao
full_name: Yuan, Biao
last_name: Yuan
- first_name: Kadin T.
full_name: Crosby, Kadin T.
last_name: Crosby
- first_name: Max
full_name: Krebel, Max
last_name: Krebel
- first_name: Xiye
full_name: Chen, Xiye
last_name: Chen
- first_name: Jakub S.
full_name: Nowak, Jakub S.
last_name: Nowak
- first_name: Andrzej
full_name: Chramiec-Głąbik, Andrzej
last_name: Chramiec-Głąbik
- first_name: Bamidele
full_name: Filani, Bamidele
last_name: Filani
- first_name: Anne-Sophie
full_name: Gribling-Burrer, Anne-Sophie
last_name: Gribling-Burrer
- first_name: Wiep
full_name: van der Toorn, Wiep
last_name: van der Toorn
- first_name: Max
full_name: von Kleist, Max
last_name: von Kleist
- first_name: Tatjana
full_name: Achmedov, Tatjana
last_name: Achmedov
- first_name: Redmond P.
full_name: Smyth, Redmond P.
last_name: Smyth
- first_name: Sebastian
full_name: Glatt, Sebastian
last_name: Glatt
- first_name: Jack Peter Kelly
full_name: Bravo, Jack Peter Kelly
id: 96aecfa5-8931-11ee-af30-aa6a5d6eee0e
last_name: Bravo
orcid: 0000-0003-0456-0753
- first_name: Dirk W.
full_name: Heinz, Dirk W.
last_name: Heinz
- first_name: Ryan N.
full_name: Jackson, Ryan N.
last_name: Jackson
- first_name: Chase L.
full_name: Beisel, Chase L.
last_name: Beisel
citation:
ama: Dmytrenko O, Yuan B, Crosby KT, et al. RNA-triggered Cas12a3 cleaves tRNA tails
to execute bacterial immunity. Nature. 2026;649:1312-1321. doi:10.1038/s41586-025-09852-9
apa: Dmytrenko, O., Yuan, B., Crosby, K. T., Krebel, M., Chen, X., Nowak, J. S.,
… Beisel, C. L. (2026). RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial
immunity. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-09852-9
chicago: Dmytrenko, Oleg, Biao Yuan, Kadin T. Crosby, Max Krebel, Xiye Chen, Jakub
S. Nowak, Andrzej Chramiec-Głąbik, et al. “RNA-Triggered Cas12a3 Cleaves TRNA
Tails to Execute Bacterial Immunity.” Nature. Springer Nature, 2026. https://doi.org/10.1038/s41586-025-09852-9.
ieee: O. Dmytrenko et al., “RNA-triggered Cas12a3 cleaves tRNA tails to execute
bacterial immunity,” Nature, vol. 649. Springer Nature, pp. 1312–1321,
2026.
ista: Dmytrenko O, Yuan B, Crosby KT, Krebel M, Chen X, Nowak JS, Chramiec-Głąbik
A, Filani B, Gribling-Burrer A-S, van der Toorn W, von Kleist M, Achmedov T, Smyth
RP, Glatt S, Bravo JPK, Heinz DW, Jackson RN, Beisel CL. 2026. RNA-triggered Cas12a3
cleaves tRNA tails to execute bacterial immunity. Nature. 649, 1312–1321.
mla: Dmytrenko, Oleg, et al. “RNA-Triggered Cas12a3 Cleaves TRNA Tails to Execute
Bacterial Immunity.” Nature, vol. 649, Springer Nature, 2026, pp. 1312–21,
doi:10.1038/s41586-025-09852-9.
short: O. Dmytrenko, B. Yuan, K.T. Crosby, M. Krebel, X. Chen, J.S. Nowak, A. Chramiec-Głąbik,
B. Filani, A.-S. Gribling-Burrer, W. van der Toorn, M. von Kleist, T. Achmedov,
R.P. Smyth, S. Glatt, J.P.K. Bravo, D.W. Heinz, R.N. Jackson, C.L. Beisel, Nature
649 (2026) 1312–1321.
das_tickbox: '1'
dataavailabilitystatement: 'The Illumina-based PFS screen data and the direct RNA
Nanopore sequencing reads have been deposited into the European Nucleotide Archive
under accession code PRJEB88250 (https://www.ebi.ac.uk/ena/browser/view/PRJEB88250).
Models and associated cryo-EM maps have been deposited into the Electron Microscopy
Data Bank (EMD) and PDB databases with the following accession codes: Ba1Cas12a3
binary complex (EMD-52275; PDB: 9HLX); Ba1Cas12a3 ternary complex (EMD-52287; PDB:
9HM6); Ba1Cas12a3 quaternary complex at pre-cleavage state (EMD-52285; PDB: 9HM4);
and Ba1Cas12a3 quaternary complex at post-cleavage state (EMD-52286; PDB: 9HM5).
Raw gel images are included as Supplementary Fig. 1. Source data are provided with
this paper.'
date_created: 2026-01-08T07:57:17Z
date_published: 2026-01-29T00:00:00Z
date_updated: 2026-07-27T10:36:28Z
day: '29'
ddc:
- '570'
department:
- _id: JaBr
doi: 10.1038/s41586-025-09852-9
external_id:
pmid:
- '41501459'
file:
- access_level: open_access
checksum: f6b40af573fc7c0c0195e1428b1d0143
content_type: application/pdf
creator: dernst
date_created: 2026-07-27T10:35:26Z
date_updated: 2026-07-27T10:35:26Z
file_id: '22415'
file_name: 2026_Nature_Dmytrenko.pdf
file_size: 28253320
relation: main_file
success: 1
file_date_updated: 2026-07-27T10:35:26Z
fulldoi: https://doi.org/10.1038/s41586-025-09852-9
has_accepted_license: '1'
intvolume: ' 649'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 1312-1321
pmid: 1
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 649
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22295'
abstract:
- lang: eng
text: 'Despite the functional diversity of over 100 causal genes1,2,3, phenotypic
convergence across models may reveal common neurobiological processes in autism
spectrum disorder (ASD). Here we profiled 251 samples from 11 monogenic mouse
models of ASD using single-nucleus multi-omic sequencing across three developmental
stages, both sexes and two brain regions. Despite genetic heterogeneity, ASD-linked
mutations converged on perturbations of the radial glial cell lineage. These alterations
reflect a transient developmental delay rather than lasting lineage misspecification
and resolve by postnatal stages. Molecularly, the largest transcriptional differences
emerged in neurons at early postnatal stages. These changes included downregulation
of synaptic and ion channel-related genes, consistent with homeostatic adaptation
or delayed maturation. Network analysis showed molecular convergence across models
within each developmental stage, suggesting that diverse mutations linked to ASD
impinge on common, stage-specific processes. Convergence becomes less pronounced
by postnatal day 14, highlighting the dynamic nature of ASD-associated changes.
Cross-genotype heterogeneity is superimposed on stage-specific effects. Electrophysiology
corroborated this pattern: mutants generally showed altered neuronal excitability
and synaptic properties with model-specific nuances. Our study also highlighted
sex-specific gene expression alterations, with female mice often displaying larger
effect sizes than male mice. Together, our findings provide a comprehensive view
of developmental cellular and molecular dynamics across models of ASD.'
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: We thank F. Freeman, V. Voronin and M. Ladron de Guevara for technical
assistance; A. Stichelberger and S. Liegenfeld for the management of our animal
colony; M. Schunn, C. Gold and the Preclinical Facility team for technical assistance;
C. Jansen and the Scientific Computing Facility for bioinformatics support and technical
assistance; the Biomedical Sequencing Facility at CeMM for assistance with next-generation
sequencing; and J. Lin and T. Krausgruber in the laboratory of C. Bock for support
with flow cytometry; J. Kirchner for illustrating the multi-omics approach depicted
in Fig. 1; and all members of the laboratory of G.N. for their support and discussions.
This study was supported by the Scientific Service Units of ISTA through resources
provided by the Imaging & Optics Facility and the Laboratory Support Facility. Bulk
RNA-seq was performed by the Next Generation Sequencing Facility at Vienna BioCenter
Core Facilities, member of the Vienna BioCenter. This work was supported by a European
Research Council Consolidator Grant (PR1028ERC02), by SFARI (PR1028SIM02) and by
the Austrian Science Fund (PE1028W1232 and PR1028FG1803) to G.N. Open access funding
provided by Institute of Science and Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Lena A
full_name: Schwarz, Lena A
id: 29A8453C-F248-11E8-B48F-1D18A9856A87
last_name: Schwarz
- first_name: Christoph
full_name: Dotter, Christoph
id: 4C66542E-F248-11E8-B48F-1D18A9856A87
last_name: Dotter
orcid: 0000-0002-9033-9096
- first_name: Sergey
full_name: Isaev, Sergey
last_name: Isaev
- first_name: Michela
full_name: Lisi, Michela
id: 39383c1b-d3eb-11ef-8d6c-c8cdf4e10c8c
last_name: Lisi
- first_name: Daniel
full_name: Malzl, Daniel
last_name: Malzl
- first_name: Christoph
full_name: Büschl, Christoph
id: 2a8c054c-0913-11ee-9159-f8ef515809ed
last_name: Büschl
- first_name: Sabrina
full_name: Ladstätter, Sabrina
last_name: Ladstätter
- first_name: Bárbara
full_name: Oliveira, Bárbara
id: 3B03AA1A-F248-11E8-B48F-1D18A9856A87
last_name: Oliveira
- first_name: Matteo
full_name: Barel, Matteo
id: 8959927b-2236-11ed-bd6e-ea83d94ade0e
last_name: Barel
- first_name: Bernadette
full_name: Basilico, Bernadette
id: 36035796-5ACA-11E9-A75E-7AF2E5697425
last_name: Basilico
orcid: 0000-0003-1843-3173
- first_name: Chaitanya
full_name: Chintaluri, Chaitanya
id: BA06AFEE-A4BA-11EA-AE5C-14673DDC885E
last_name: Chintaluri
orcid: 0000-0003-4252-1608
- first_name: Sarah
full_name: Gorkiewicz, Sarah
id: f141a35d-15a9-11ec-9fb2-fef6becc7b6f
last_name: Gorkiewicz
- first_name: Mohammad
full_name: Goudarzi, Mohammad
id: 3384113A-F248-11E8-B48F-1D18A9856A87
last_name: Goudarzi
- first_name: Tereza
full_name: Belinova, Tereza
id: 0bf89b6a-d28b-11eb-8bd6-f43768e4d368
last_name: Belinova
- first_name: Stephan
full_name: Reichl, Stephan
last_name: Reichl
- first_name: Gintarė
full_name: Sendžikaitė, Gintarė
id: dd6d52f2-c50d-11eb-9548-bcf0ff82b344
last_name: Sendžikaitė
- first_name: Satish
full_name: Arcot Jayaram, Satish
id: b0bbee33-09f7-11eb-909c-8b358058d28a
last_name: Arcot Jayaram
orcid: 0000-0002-2479-2669
- first_name: Peter
full_name: Koppensteiner, Peter
id: 3B8B25A8-F248-11E8-B48F-1D18A9856A87
last_name: Koppensteiner
orcid: 0000-0002-3509-1948
- first_name: Christoph M
full_name: Sommer, Christoph M
id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
last_name: Sommer
orcid: 0000-0003-1216-9105
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
- first_name: Jörg
full_name: Menche, Jörg
last_name: Menche
- first_name: Igor
full_name: Adameyko, Igor
last_name: Adameyko
- first_name: Peter Vasili
full_name: Kharchenko, Peter Vasili
id: 0095641e-7eb7-11f1-8665-aec51a2ab5e0
last_name: Kharchenko
- first_name: Christoph
full_name: Bock, Christoph
last_name: Bock
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
citation:
ama: Schwarz LA, Dotter C, Isaev S, et al. Cortical development dynamics across
autism spectrum disorder mouse models. Nature. 2026. doi:10.1038/s41586-026-10679-1
apa: Schwarz, L. A., Dotter, C., Isaev, S., Lisi, M., Malzl, D., Büschl, C., … Novarino,
G. (2026). Cortical development dynamics across autism spectrum disorder mouse
models. Nature. Springer Nature. https://doi.org/10.1038/s41586-026-10679-1
chicago: Schwarz, Lena A, Christoph Dotter, Sergey Isaev, Michela Lisi, Daniel Malzl,
Christoph Büschl, Sabrina Ladstätter, et al. “Cortical Development Dynamics across
Autism Spectrum Disorder Mouse Models.” Nature. Springer Nature, 2026.
https://doi.org/10.1038/s41586-026-10679-1.
ieee: L. A. Schwarz et al., “Cortical development dynamics across autism
spectrum disorder mouse models,” Nature. Springer Nature, 2026.
ista: Schwarz LA, Dotter C, Isaev S, Lisi M, Malzl D, Büschl C, Ladstätter S, Oliveira
B, Barel M, Basilico B, Chintaluri C, Gorkiewicz S, Goudarzi M, Belinova T, Reichl
S, Sendžikaitė G, Arcot Jayaram S, Koppensteiner P, Sommer CM, Vogels TP, Menche
J, Adameyko I, Kharchenko PV, Bock C, Novarino G. 2026. Cortical development dynamics
across autism spectrum disorder mouse models. Nature.
mla: Schwarz, Lena A., et al. “Cortical Development Dynamics across Autism Spectrum
Disorder Mouse Models.” Nature, Springer Nature, 2026, doi:10.1038/s41586-026-10679-1.
short: L.A. Schwarz, C. Dotter, S. Isaev, M. Lisi, D. Malzl, C. Büschl, S. Ladstätter,
B. Oliveira, M. Barel, B. Basilico, C. Chintaluri, S. Gorkiewicz, M. Goudarzi,
T. Belinova, S. Reichl, G. Sendžikaitė, S. Arcot Jayaram, P. Koppensteiner, C.M.
Sommer, T.P. Vogels, J. Menche, I. Adameyko, P.V. Kharchenko, C. Bock, G. Novarino,
Nature (2026).
corr_author: '1'
dataavailabilitystatement: Single-nucleus multiomics data are available from the Gene
Expression Omnibus (GSE328363). The mm10 reference genome was used for the alignment
(refdata-cellranger-arc-mm10-2020-A-2.0.0, obtained from https://cf.10xgenomics.com/supp/cell-arc/refdata-cellranger-arc-mm10-2020-A-2.0.0.tar.gz).
Single-cell data can be accessed and visualized through a CELLxGENE database (https://adameykolab.hifo.meduniwien.ac.at/cellxgene_public/filecrawl/.2026_Nature_Schwarz).
Source data are provided with this paper. Scripts and analyses that support the
main findings of this study are accessible in a GitHub repository (https://git.ista.ac.at/research-sofware/mouseome).
date_created: 2026-07-13T09:47:21Z
date_published: 2026-06-17T00:00:00Z
date_updated: 2026-08-04T09:29:55Z
day: '17'
ddc:
- '570'
department:
- _id: AnKi
- _id: GaNo
- _id: TiVo
- _id: ScienComp
- _id: GradSch
- _id: Bio
- _id: PreCl
doi: 10.1038/s41586-026-10679-1
external_id:
pmid:
- '42310454'
fulldoi: https://doi.org/10.1038/s41586-026-10679-1
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41586-026-10679-1
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 34ba8964-11ca-11ed-8bc3-e15864e7e9a6
grant_number: '101044865'
name: Toward an understanding of the brain interstitial system and the extracellular
proteome in health and autism spectrum disorders
- _id: 9B91375C-BA93-11EA-9121-9846C619BF3A
grant_number: '707964'
name: Critical windows and reversibility of ASD associated with mutations in chromatin
remodelers
- _id: 2548AE96-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232
name: Molecular Drug Targets
- _id: ebb38b5d-77a9-11ec-83b8-a42e08120a88
grant_number: FG1803 49015
name: Neurobiology of anxiety in autism spectrum disorders
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/patterns-in-genetic-chaos/
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Cortical development dynamics across autism spectrum disorder mouse models
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22751'
abstract:
- lang: eng
text: 'The physical processes that led to the formation of billion-solar-mass black
holes within the first 700 million years of cosmic time, a period known as cosmic
dawn, remain a puzzle1. Several theoretical scenarios have been proposed to seed
and rapidly grow black holes2,3,4, but direct observations of these mechanisms
remain elusive. Here we present a source 660 million years after the Big Bang
that exhibits singular properties: among the largest hydrogen Balmer breaks reported
at any redshift, broad multi-peaked Hβ emission, and Balmer line absorption in
several transitions. We model this source as an enshrouded black hole in which
the Balmer break and absorption features are a result of extremely dense, turbulent
gas forming a dust-free envelope around a supermassive black hole5,6. This source
may provide evidence of an early black hole embedded in dense gas—a theoretical
configuration proposed to rapidly grow black holes by super-Eddington accretion7,8.
Radiation from the black hole seems to dominate almost all observed light, leaving
limited room for contribution from its host galaxy. If the source merged with
its brighter neighbour, it would resemble the recently discovered ‘little red
dots’ with perplexing spectral energy distributions9,10,11. The redness of the
black hole is due to gas, not dust12,13, and scattering, not kinematics, gives
rise to the complex line shapes and luminosities—black hole masses of these sources
may therefore be overestimated by orders of magnitude.'
acknowledgement: This work is based on observations made with the NASA/ESA/CSA James
Webb Space Telescope. The data were obtained from the Mikulski Archive for Space
Telescopes at the Space Telescope Science Institute, which is operated by the Association
of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127
for JWST. These observations are associated with programs 5224 and 3543. R.P.N.
is a NASA Hubble Fellow. D.J.S. is a Brinson Prize Fellow. Some of the data products
presented in this study were retrieved from the DJA. DJA is an initiative of the
Cosmic Dawn Center (DAWN), which is funded by the Danish National Research Foundation
under grant DNRF140. We acknowledge funding from JWST programmes GO-3516, GO-5224
and GO-1837. Support for this work was provided by NASA through the NASA Hubble
Fellowship grant HST-HF2-51515.001-A awarded by the Space Telescope Science Institute,
which is operated by the Association of Universities for Research in Astronomy,
Incorporated, under NASA contract NAS5-26555. Funded by the European Union (ERC
AGENTS, 101076224; HEAVYMETAL, 101071865; RED CARDINAL, 101076080). Views and opinions
expressed are however those of the author(s) only and do not necessarily reflect
those of the European Union or the European Research Council. Neither the European
Union nor the granting authority can be held responsible for them. This work has
received funding from the Swiss State Secretariat for Education, Research and Innovation
(SERI) under contract number MB22.00072, as well as from the Swiss National Science
Foundation (SNSF) through project grant 200020_207349. This work was also supported
by JSPS KAKENHI grant no. 23H00131. The Cosmic Dawn Center is funded by the Danish
National Research Foundation under grant DNRF140. P.N. acknowledges support from
the Gordon and Betty Moore Foundation and the John Templeton Foundation that fund
the Black Hole Initiative (BHI) at Harvard University, where she serves as an external
prinicpal investigator. S. Bose acknowledges funding from a UK Research and Innovation
(UKRI) Future Leaders Fellowship (grant no. MR/V023381/1).
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Rohan P.
full_name: Naidu, Rohan P.
last_name: Naidu
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Harley
full_name: Katz, Harley
last_name: Katz
- first_name: Anna
full_name: De Graaff, Anna
last_name: De Graaff
- first_name: Pascal A.
full_name: Oesch, Pascal A.
last_name: Oesch
- first_name: Aaron
full_name: Smith, Aaron
last_name: Smith
- first_name: Jenny E.
full_name: Greene, Jenny E.
last_name: Greene
- first_name: Gabriel
full_name: Brammer, Gabriel
last_name: Brammer
- first_name: Andrea
full_name: Weibel, Andrea
last_name: Weibel
- first_name: Raphael
full_name: Hviding, Raphael
last_name: Hviding
- first_name: John
full_name: Chisholm, John
last_name: Chisholm
- first_name: Ivo
full_name: Labbé, Ivo
last_name: Labbé
- first_name: Robert A.
full_name: Simcoe, Robert A.
last_name: Simcoe
- first_name: Callum
full_name: Witten, Callum
last_name: Witten
- first_name: Wendy Q.
full_name: Sun, Wendy Q.
last_name: Sun
- first_name: Hakim
full_name: Atek, Hakim
last_name: Atek
- first_name: Josephine F.W.
full_name: Baggen, Josephine F.W.
last_name: Baggen
- first_name: Sirio
full_name: Belli, Sirio
last_name: Belli
- first_name: Rachel
full_name: Bezanson, Rachel
last_name: Bezanson
- first_name: Leindert A.
full_name: Boogaard, Leindert A.
last_name: Boogaard
- first_name: Sownak
full_name: Bose, Sownak
last_name: Bose
- first_name: Rychard J.
full_name: Bouwens, Rychard J.
last_name: Bouwens
- first_name: Alba
full_name: Covelo-Paz, Alba
last_name: Covelo-Paz
- first_name: Pratika
full_name: Dayal, Pratika
last_name: Dayal
- first_name: Yoshinobu
full_name: Fudamoto, Yoshinobu
last_name: Fudamoto
- first_name: Lukas J.
full_name: Furtak, Lukas J.
last_name: Furtak
- first_name: Emma
full_name: Giovinazzo, Emma
last_name: Giovinazzo
- first_name: Andy
full_name: Goulding, Andy
last_name: Goulding
- first_name: Max
full_name: Gronke, Max
last_name: Gronke
- first_name: Kasper E.
full_name: Heintz, Kasper E.
last_name: Heintz
- first_name: Michaela
full_name: Hirschmann, Michaela
last_name: Hirschmann
- first_name: Garth
full_name: Illingworth, Garth
last_name: Illingworth
- first_name: Akio K.
full_name: Inoue, Akio K.
last_name: Inoue
- first_name: Benjamin D.
full_name: Johnson, Benjamin D.
last_name: Johnson
- first_name: Joel
full_name: Leja, Joel
last_name: Leja
- first_name: Ecaterina
full_name: Leonova, Ecaterina
last_name: Leonova
- first_name: Ian
full_name: Mcconachie, Ian
last_name: Mcconachie
- first_name: Michael V.
full_name: Maseda, Michael V.
last_name: Maseda
- first_name: Priyamvada
full_name: Natarajan, Priyamvada
last_name: Natarajan
- first_name: Erica
full_name: Nelson, Erica
last_name: Nelson
- first_name: David J.
full_name: Setton, David J.
last_name: Setton
- first_name: Irene
full_name: Shivaei, Irene
last_name: Shivaei
- first_name: David
full_name: Sobral, David
last_name: Sobral
- first_name: Mauro
full_name: Stefanon, Mauro
last_name: Stefanon
- first_name: Sandro
full_name: Tacchella, Sandro
last_name: Tacchella
- first_name: Sune
full_name: Toft, Sune
last_name: Toft
- first_name: Alberto
full_name: Torralba Torregrosa, Alberto
id: 018f0249-0e87-11f0-b167-cbce08fbd541
last_name: Torralba Torregrosa
orcid: 0000-0001-5586-6950
- first_name: Pieter
full_name: Van Dokkum, Pieter
last_name: Van Dokkum
- first_name: Arjen
full_name: Van Der Wel, Arjen
last_name: Van Der Wel
- first_name: Marta
full_name: Volonteri, Marta
last_name: Volonteri
- first_name: Fabian
full_name: Walter, Fabian
last_name: Walter
- first_name: Bingjie
full_name: Wang, Bingjie
last_name: Wang
- first_name: Darach
full_name: Watson, Darach
last_name: Watson
- first_name: Katherine
full_name: Whitaker, Katherine
last_name: Whitaker
citation:
ama: Naidu RP, Matthee JJ, Katz H, et al. A gas-enshrouded and gas-reddened black
hole at cosmic dawn. Nature. 2026;656(8127):329-333. doi:10.1038/s41586-026-10846-4
apa: Naidu, R. P., Matthee, J. J., Katz, H., De Graaff, A., Oesch, P. A., Smith,
A., … Whitaker, K. (2026). A gas-enshrouded and gas-reddened black hole at cosmic
dawn. Nature. Springer Nature. https://doi.org/10.1038/s41586-026-10846-4
chicago: Naidu, Rohan P., Jorryt J Matthee, Harley Katz, Anna De Graaff, Pascal
A. Oesch, Aaron Smith, Jenny E. Greene, et al. “A Gas-Enshrouded and Gas-Reddened
Black Hole at Cosmic Dawn.” Nature. Springer Nature, 2026. https://doi.org/10.1038/s41586-026-10846-4.
ieee: R. P. Naidu et al., “A gas-enshrouded and gas-reddened black hole at
cosmic dawn,” Nature, vol. 656, no. 8127. Springer Nature, pp. 329–333,
2026.
ista: Naidu RP, Matthee JJ, Katz H, De Graaff A, Oesch PA, Smith A, Greene JE, Brammer
G, Weibel A, Hviding R, Chisholm J, Labbé I, Simcoe RA, Witten C, Sun WQ, Atek
H, Baggen JFW, Belli S, Bezanson R, Boogaard LA, Bose S, Bouwens RJ, Covelo-Paz
A, Dayal P, Fudamoto Y, Furtak LJ, Giovinazzo E, Goulding A, Gronke M, Heintz
KE, Hirschmann M, Illingworth G, Inoue AK, Johnson BD, Leja J, Leonova E, Mcconachie
I, Maseda MV, Natarajan P, Nelson E, Setton DJ, Shivaei I, Sobral D, Stefanon
M, Tacchella S, Toft S, Torralba Torregrosa A, Van Dokkum P, Van Der Wel A, Volonteri
M, Walter F, Wang B, Watson D, Whitaker K. 2026. A gas-enshrouded and gas-reddened
black hole at cosmic dawn. Nature. 656(8127), 329–333.
mla: Naidu, Rohan P., et al. “A Gas-Enshrouded and Gas-Reddened Black Hole at Cosmic
Dawn.” Nature, vol. 656, no. 8127, Springer Nature, 2026, pp. 329–33, doi:10.1038/s41586-026-10846-4.
short: R.P. Naidu, J.J. Matthee, H. Katz, A. De Graaff, P.A. Oesch, A. Smith, J.E.
Greene, G. Brammer, A. Weibel, R. Hviding, J. Chisholm, I. Labbé, R.A. Simcoe,
C. Witten, W.Q. Sun, H. Atek, J.F.W. Baggen, S. Belli, R. Bezanson, L.A. Boogaard,
S. Bose, R.J. Bouwens, A. Covelo-Paz, P. Dayal, Y. Fudamoto, L.J. Furtak, E. Giovinazzo,
A. Goulding, M. Gronke, K.E. Heintz, M. Hirschmann, G. Illingworth, A.K. Inoue,
B.D. Johnson, J. Leja, E. Leonova, I. Mcconachie, M.V. Maseda, P. Natarajan, E.
Nelson, D.J. Setton, I. Shivaei, D. Sobral, M. Stefanon, S. Tacchella, S. Toft,
A. Torralba Torregrosa, P. Van Dokkum, A. Van Der Wel, M. Volonteri, F. Walter,
B. Wang, D. Watson, K. Whitaker, Nature 656 (2026) 329–333.
das_tickbox: '1'
dataavailabilitystatement: 'The prism spectra obtained as part of JWST-GO-5224 (MoM)
featured in this work are available on Zenodo (https://doi.org/10.5281/zenodo.15059214).
All processed images and spectra used in this work are publicly available via the
DAWN JWST archive (https://dawn-cph.github.io/dja/). All results presented may be
reproduced with the open-access reduced data described above and using the following
publicly available software whose use is referenced in the text: msaexp, grizli,
astropy, Cloudy, SpectRes, pysersic, COLT and numpyro.'
date_created: 2026-08-23T22:01:46Z
date_published: 2026-08-13T00:00:00Z
date_updated: 2026-09-07T12:50:34Z
day: '13'
ddc:
- '520'
department:
- _id: JoMa
doi: 10.1038/s41586-026-10846-4
external_id:
pmid:
- '42587117'
file:
- access_level: open_access
checksum: 80127691cb39deb39948c337f6915f7b
content_type: application/pdf
creator: dernst
date_created: 2026-09-07T12:49:32Z
date_updated: 2026-09-07T12:49:32Z
file_id: '22841'
file_name: 2026_Nature_Naidu.pdf
file_size: 15134062
relation: main_file
success: 1
file_date_updated: 2026-09-07T12:49:32Z
fulldoi: https://doi.org/10.1038/s41586-026-10846-4
has_accepted_license: '1'
intvolume: ' 656'
issue: '8127'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 329-333
pmid: 1
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: A gas-enshrouded and gas-reddened black hole at cosmic dawn
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 656
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22753'
abstract:
- lang: eng
text: Radial glial progenitors (RGPs) produce all excitatory neurons in the developing
cerebral cortex. Mosaic analysis with double markers (MADM)-based lineage tracing
in vivo has revealed a quantitative framework of RGP lineage progression1. Here
we established MADM technology2,3 in mouse embryonic stem cells to probe RGP lineage
progression in a self-organizing cortical organoid system. We found that RGPs
exhibit a high level of plasticity in proliferative potential in organoids rather
than strict temporally stereotyped lineage progression as observed in vivo. RGPs
in organoids showed increased lineage restriction, diminishing cell-type diversity
in clones of cortical projection neurons, despite uniform single-cell transcriptional
signatures of RGPs and a unitary lineage trajectory. Thus, critical non-cell-autonomous
cues that are absent in self-organizing systems and/or the genuine stem cell niche
are essential for faithful temporal control of RGP lineage progression and the
generation of clonal cortical cell-type diversity.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: PreCl
acknowledgement: We thank M. L. de Guevara, S. Jayaram and A. Heger for technical
assistance with mESC derivation; M. Goudarzi for assistance with organoid imaging;
M. Leeb and F. Freeman for advice in culturing mESCs and organoids; S. Gobeil and
L. Sweeney for reagents and advice for organoid clearing; A. Heger for mouse colony
management; J. Hauser for technical assistance; the Stanford Brain Organogenesis
Workshop; and all members of the Hippenmeyer laboratory for discussion and/or comments
on the manuscript. This study was supported by the Scientific Service Units (SSU)
of the Institute of Science and Technology, Austria through resources provided by
the Imaging and Optics Facility (IOF), Laboratory Support Facility (LSF) and Preclinical
Facility (PCF). M.S. received funding from the European Commission (IST plus postdoctoral
fellowship). This work was supported by ISTA institutional funds to S.H., FWF SFB
F78 Neuro Stem Modulation to S.H., and by the European Research Council (ERC) under
the European Union’s Horizon 2020 Research And Innovation Program (grant agreement
725780 LinPro) to S.H. Open access funding provided by Institute of Science and
Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Melissa A
full_name: Stouffer, Melissa A
id: 4C9372C4-F248-11E8-B48F-1D18A9856A87
last_name: Stouffer
- first_name: Osvaldo
full_name: Miranda, Osvaldo
id: 862A3C56-A8BF-11E9-B4FA-D9E3E5697425
last_name: Miranda
orcid: 0000-0001-6618-6889
- first_name: Florian
full_name: Pauler, Florian
id: 48EA0138-F248-11E8-B48F-1D18A9856A87
last_name: Pauler
orcid: 0000-0002-7462-0048
- first_name: Fabrizia
full_name: Pipicelli, Fabrizia
id: 649134fd-d012-11ed-8f82-db1e5050f9ba
last_name: Pipicelli
- first_name: Carmen
full_name: Streicher, Carmen
id: 36BCB99C-F248-11E8-B48F-1D18A9856A87
last_name: Streicher
- first_name: Giselle T
full_name: Cheung, Giselle T
id: 471195F6-F248-11E8-B48F-1D18A9856A87
last_name: Cheung
orcid: 0000-0001-8457-2572
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
citation:
ama: Stouffer MA, Miranda O, Pauler F, et al. Temporal uncoupling of radial glia
lineage progression in cortical organoids. Nature. 2026. doi:10.1038/s41586-026-10916-7
apa: Stouffer, M. A., Miranda, O., Pauler, F., Pipicelli, F., Streicher, C., Cheung,
G. T., & Hippenmeyer, S. (2026). Temporal uncoupling of radial glia lineage
progression in cortical organoids. Nature. Springer Nature. https://doi.org/10.1038/s41586-026-10916-7
chicago: Stouffer, Melissa A, Osvaldo Miranda, Florian Pauler, Fabrizia Pipicelli,
Carmen Streicher, Giselle T Cheung, and Simon Hippenmeyer. “Temporal Uncoupling
of Radial Glia Lineage Progression in Cortical Organoids.” Nature. Springer
Nature, 2026. https://doi.org/10.1038/s41586-026-10916-7.
ieee: M. A. Stouffer et al., “Temporal uncoupling of radial glia lineage
progression in cortical organoids,” Nature. Springer Nature, 2026.
ista: Stouffer MA, Miranda O, Pauler F, Pipicelli F, Streicher C, Cheung GT, Hippenmeyer
S. 2026. Temporal uncoupling of radial glia lineage progression in cortical organoids.
Nature.
mla: Stouffer, Melissa A., et al. “Temporal Uncoupling of Radial Glia Lineage Progression
in Cortical Organoids.” Nature, Springer Nature, 2026, doi:10.1038/s41586-026-10916-7.
short: M.A. Stouffer, O. Miranda, F. Pauler, F. Pipicelli, C. Streicher, G.T. Cheung,
S. Hippenmeyer, Nature (2026).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: All data generated and analysed in this study are included
in the paper, source data and/or Supplementary Tables 2 and 3. Raw sequencing data
have been deposited with Gene Expression Omnibus (GEO) accession number GSE327470.
Source data are provided with this paper. All scripts used to prepare data and figures
for this manuscript are accessible on GitHub at https://github.com/fpauler/Temporal-Uncoupling-of-Radial-Glia-Lineage-Progression-in-Cortical-Organoid.
date_created: 2026-08-23T22:01:47Z
date_published: 2026-08-12T00:00:00Z
date_updated: 2026-09-09T07:11:02Z
day: '12'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1038/s41586-026-10916-7
ec_funded: 1
external_id:
pmid:
- '42587153'
file:
- access_level: open_access
checksum: 11383e28fc430b28d2666f73833e8b56
content_type: application/pdf
creator: dernst
date_created: 2026-09-07T13:24:10Z
date_updated: 2026-09-07T13:24:10Z
file_id: '22844'
file_name: 2026_Nature_Stouffer.pdf
file_size: 48513068
relation: main_file
success: 1
file_date_updated: 2026-09-07T13:24:10Z
fulldoi: https://doi.org/10.1038/s41586-026-10916-7
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 059F6AB4-7A3F-11EA-A408-12923DDC885E
grant_number: F7805
name: Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular
Mechanisms of Neural Stem Cell Lineage Progression
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Temporal uncoupling of radial glia lineage progression in cortical organoids
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21548'
abstract:
- lang: eng
text: "Non-Abelian gauge fields provide a conceptual framework to describe particles\r\nhaving
spins, underlying many phenomena in electrodynamics, condensed-matter\r\nphysics
and particle physics. Lattice models of non-Abelian gauge fields allow us\r\nto
understand their physical implications in extended systems. The theoretical\r\nimportance
of non-Abelian lattice gauge fields motivates their experimental synthesis\r\nand
explorations. Photons are fundamental particles for which artificial gauge fields\r\ncan
be synthesized, yet the demonstration of non-Abelian lattice gauge fields for\r\nphotons
has not been achieved. Here we demonstrate SU(2) lattice gauge fields for\r\nphotons
in the synthetic frequency dimensions, a playground to study lattice\r\nphysics
in a scalable and programmable way. In our lattice model, we theoretically\r\nobserve
that homogeneous non-Abelian lattice gauge potentials induce Dirac cones\r\nat
time-reversal-invariant momenta in the Brillouin zone. We experimentally confirm\r\nthe
presence of non-Abelian lattice gauge fields by two signatures: linear band\r\ncrossings
at the Dirac cones, and the associated direction reversal of eigenstate\r\ntrajectories.
We further demonstrate a non-Abelian scalar lattice gauge potential that\r\nlifts
the degeneracies of the Dirac cones. Our results highlight the implications of\r\nnon-Abelian
lattice gauge fields in topological physics, and provide a starting point\r\nfor
demonstrations of emerging non-Abelian physics in the photonic synthetic\r\ndimensions.
Our results may also benefit photonic technologies by providing controls\r\nof
photon spins and pseudo-spins in topologically non-trivial ways."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Dali
full_name: Cheng, Dali
last_name: Cheng
- first_name: Kai
full_name: Wang, Kai
last_name: Wang
- first_name: Charles
full_name: Roques-Carmes, Charles
id: e2e68fc9-6505-11ef-a541-eb4e72cc3e82
last_name: Roques-Carmes
- first_name: Eran
full_name: Lustig, Eran
last_name: Lustig
- first_name: Olivia Y.
full_name: Long, Olivia Y.
last_name: Long
- first_name: Heming
full_name: Wang, Heming
last_name: Wang
- first_name: Shanhui
full_name: Fan, Shanhui
last_name: Fan
citation:
ama: Cheng D, Wang K, Roques-Carmes C, et al. Non-Abelian lattice gauge fields in
photonic synthetic frequency dimensions. Nature. 2025;637(8044):52-56.
doi:10.1038/s41586-024-08259-2
apa: Cheng, D., Wang, K., Roques-Carmes, C., Lustig, E., Long, O. Y., Wang, H.,
& Fan, S. (2025). Non-Abelian lattice gauge fields in photonic synthetic frequency
dimensions. Nature. Springer Nature. https://doi.org/10.1038/s41586-024-08259-2
chicago: Cheng, Dali, Kai Wang, Charles Roques-Carmes, Eran Lustig, Olivia Y. Long,
Heming Wang, and Shanhui Fan. “Non-Abelian Lattice Gauge Fields in Photonic Synthetic
Frequency Dimensions.” Nature. Springer Nature, 2025. https://doi.org/10.1038/s41586-024-08259-2.
ieee: D. Cheng et al., “Non-Abelian lattice gauge fields in photonic synthetic
frequency dimensions,” Nature, vol. 637, no. 8044. Springer Nature, pp.
52–56, 2025.
ista: Cheng D, Wang K, Roques-Carmes C, Lustig E, Long OY, Wang H, Fan S. 2025.
Non-Abelian lattice gauge fields in photonic synthetic frequency dimensions. Nature.
637(8044), 52–56.
mla: Cheng, Dali, et al. “Non-Abelian Lattice Gauge Fields in Photonic Synthetic
Frequency Dimensions.” Nature, vol. 637, no. 8044, Springer Nature, 2025,
pp. 52–56, doi:10.1038/s41586-024-08259-2.
short: D. Cheng, K. Wang, C. Roques-Carmes, E. Lustig, O.Y. Long, H. Wang, S. Fan,
Nature 637 (2025) 52–56.
date_created: 2026-03-30T12:22:47Z
date_published: 2025-01-02T00:00:00Z
date_updated: 2026-04-27T07:14:06Z
day: '02'
ddc:
- '530'
doi: 10.1038/s41586-024-08259-2
extern: '1'
external_id:
arxiv:
- '2406.00321'
pmid:
- '39743600'
fulldoi: https://doi.org/10.1038/s41586-024-08259-2
intvolume: ' 637'
issue: '8044'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2406.00321
month: '01'
oa: 1
oa_version: Preprint
page: 52-56
pmid: 1
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Non-Abelian lattice gauge fields in photonic synthetic frequency dimensions
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 637
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21549'
abstract:
- lang: eng
text: Integrated photonics, particularly silicon photonics, have emerged as cutting-edge
technology driven by promising applications such as short-reach communications,
autonomous driving, biosensing and photonic computing1,2,3,4. As advances in AI
lead to growing computing demands, photonic computing has gained considerable
attention as an appealing candidate. Nonetheless, there are substantial technical
challenges in the scaling up of integrated photonics systems to realize these
advantages, such as ensuring consistent performance gains in upscaled integrated
device clusters, establishing standard designs and verification processes for
complex circuits, as well as packaging large-scale systems. These obstacles arise
primarily because of the relative immaturity of integrated photonics manufacturing
and the scarcity of advanced packaging solutions involving photonics. Here we
report a large-scale integrated photonic accelerator comprising more than 16,000
photonic components. The accelerator is designed to deliver standard linear matrix
multiply–accumulate (MAC) functions, enabling computing with high speed up to
1 GHz frequency and low latency as small as 3 ns per cycle. Logic, memory and
control functions that support photonic matrix MAC operations were designed into
a cointegrated electronics chip. To seamlessly integrate the electronics and photonics
chips at the commercial scale, we have made use of an innovative 2.5D hybrid advanced
packaging approach. Through the development of this accelerator system, we demonstrate
an ultralow computation latency for heuristic solvers of computationally hard
Ising problems whose performance greatly relies on the computing latency.
article_processing_charge: No
article_type: original
author:
- first_name: Shiyue
full_name: Hua, Shiyue
last_name: Hua
- first_name: Erwan
full_name: Divita, Erwan
last_name: Divita
- first_name: Shanshan
full_name: Yu, Shanshan
last_name: Yu
- first_name: Bo
full_name: Peng, Bo
last_name: Peng
- first_name: Charles
full_name: Roques-Carmes, Charles
id: e2e68fc9-6505-11ef-a541-eb4e72cc3e82
last_name: Roques-Carmes
- first_name: Zhan
full_name: Su, Zhan
last_name: Su
- first_name: Zhang
full_name: Chen, Zhang
last_name: Chen
- first_name: Yanfei
full_name: Bai, Yanfei
last_name: Bai
- first_name: Jinghui
full_name: Zou, Jinghui
last_name: Zou
- first_name: Yunpeng
full_name: Zhu, Yunpeng
last_name: Zhu
- first_name: Yelong
full_name: Xu, Yelong
last_name: Xu
- first_name: Cheng-kuan
full_name: Lu, Cheng-kuan
last_name: Lu
- first_name: Yuemiao
full_name: Di, Yuemiao
last_name: Di
- first_name: Hui
full_name: Chen, Hui
last_name: Chen
- first_name: Lushan
full_name: Jiang, Lushan
last_name: Jiang
- first_name: Lijie
full_name: Wang, Lijie
last_name: Wang
- first_name: Longwu
full_name: Ou, Longwu
last_name: Ou
- first_name: Chaohong
full_name: Zhang, Chaohong
last_name: Zhang
- first_name: Junjie
full_name: Chen, Junjie
last_name: Chen
- first_name: Wen
full_name: Zhang, Wen
last_name: Zhang
- first_name: Hongyan
full_name: Zhu, Hongyan
last_name: Zhu
- first_name: Weijun
full_name: Kuang, Weijun
last_name: Kuang
- first_name: Long
full_name: Wang, Long
last_name: Wang
- first_name: Huaiyu
full_name: Meng, Huaiyu
last_name: Meng
- first_name: Maurice
full_name: Steinman, Maurice
last_name: Steinman
- first_name: Yichen
full_name: Shen, Yichen
last_name: Shen
citation:
ama: Hua S, Divita E, Yu S, et al. An integrated large-scale photonic accelerator
with ultralow latency. Nature. 2025;640:361-367. doi:10.1038/s41586-025-08786-6
apa: Hua, S., Divita, E., Yu, S., Peng, B., Roques-Carmes, C., Su, Z., … Shen, Y.
(2025). An integrated large-scale photonic accelerator with ultralow latency.
Nature. Springer Nature. https://doi.org/10.1038/s41586-025-08786-6
chicago: Hua, Shiyue, Erwan Divita, Shanshan Yu, Bo Peng, Charles Roques-Carmes,
Zhan Su, Zhang Chen, et al. “An Integrated Large-Scale Photonic Accelerator with
Ultralow Latency.” Nature. Springer Nature, 2025. https://doi.org/10.1038/s41586-025-08786-6.
ieee: S. Hua et al., “An integrated large-scale photonic accelerator with
ultralow latency,” Nature, vol. 640. Springer Nature, pp. 361–367, 2025.
ista: Hua S, Divita E, Yu S, Peng B, Roques-Carmes C, Su Z, Chen Z, Bai Y, Zou J,
Zhu Y, Xu Y, Lu C, Di Y, Chen H, Jiang L, Wang L, Ou L, Zhang C, Chen J, Zhang
W, Zhu H, Kuang W, Wang L, Meng H, Steinman M, Shen Y. 2025. An integrated large-scale
photonic accelerator with ultralow latency. Nature. 640, 361–367.
mla: Hua, Shiyue, et al. “An Integrated Large-Scale Photonic Accelerator with Ultralow
Latency.” Nature, vol. 640, Springer Nature, 2025, pp. 361–67, doi:10.1038/s41586-025-08786-6.
short: S. Hua, E. Divita, S. Yu, B. Peng, C. Roques-Carmes, Z. Su, Z. Chen, Y. Bai,
J. Zou, Y. Zhu, Y. Xu, C. Lu, Y. Di, H. Chen, L. Jiang, L. Wang, L. Ou, C. Zhang,
J. Chen, W. Zhang, H. Zhu, W. Kuang, L. Wang, H. Meng, M. Steinman, Y. Shen, Nature
640 (2025) 361–367.
date_created: 2026-03-30T12:22:47Z
date_published: 2025-04-09T00:00:00Z
date_updated: 2026-04-27T08:38:44Z
day: '09'
ddc:
- '530'
doi: 10.1038/s41586-025-08786-6
extern: '1'
external_id:
pmid:
- ' 40205213'
fulldoi: https://doi.org/10.1038/s41586-025-08786-6
intvolume: ' 640'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41586-025-08786-6
month: '04'
oa: 1
oa_version: Published Version
page: 361-367
pmid: 1
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: An integrated large-scale photonic accelerator with ultralow latency
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 640
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21912'
abstract:
- lang: eng
text: The mammalian fatty acid synthase (FASN) enzyme is a dynamic multienzyme that
belongs to the megasynthase family. In mammals, a single gene encodes six catalytically
active domains and a flexibly tethered acyl carrier protein (ACP) domain that
shuttles intermediates between active sites for fatty acid biosynthesis1. FASN
is an essential enzyme in mammalian development through the role that fatty acids
have in membrane formation, energy storage, cell signalling and protein modifications.
Thus, FASN is a promising target for treatment of a large variety of diseases
including cancer, metabolic dysfunction-associated fatty liver disease, and viral
and parasite infections2,3. The multi-faceted mechanism of FASN and the dynamic
nature of the protein, in particular of the ACP, have made it challenging to understand
at the molecular level. Here we report cryo-electron microscopy structures of
human FASN in a multitude of conformational states with NADPH and NADP+ plus acetoacetyl-CoA
present, including structures with the ACP stalled at the dehydratase (DH) and
enoyl-reductase (ER) domains. We show that FASN activity in vitro and de novo
lipogenesis in cells is inhibited by mutations at the ACP–DH and ACP–ER interfaces.
Together, these studies provide new molecular insights into the dynamic nature
of FASN and the ACP shuttling mechanism, with implications for developing improved
FASN-targeted therapeutics.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Kollin
full_name: Schultz, Kollin
last_name: Schultz
- first_name: Pedro
full_name: Costa-Pinheiro, Pedro
last_name: Costa-Pinheiro
- first_name: Lauren
full_name: Gardner, Lauren
id: f9dedd98-6d15-11f0-88a5-a7b4143fdec5
last_name: Gardner
orcid: 0009-0000-5733-1546
- first_name: Laura V.
full_name: Pinheiro, Laura V.
last_name: Pinheiro
- first_name: Julio
full_name: Ramirez-Solis, Julio
last_name: Ramirez-Solis
- first_name: Sarah M.
full_name: Gardner, Sarah M.
last_name: Gardner
- first_name: Kathryn E.
full_name: Wellen, Kathryn E.
last_name: Wellen
- first_name: Ronen
full_name: Marmorstein, Ronen
last_name: Marmorstein
citation:
ama: Schultz K, Costa-Pinheiro P, Gardner L, et al. Snapshots of acyl carrier protein
shuttling in human fatty acid synthase. Nature. 2025;641(8062):520-528.
doi:10.1038/s41586-025-08587-x
apa: Schultz, K., Costa-Pinheiro, P., Gardner, L., Pinheiro, L. V., Ramirez-Solis,
J., Gardner, S. M., … Marmorstein, R. (2025). Snapshots of acyl carrier protein
shuttling in human fatty acid synthase. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-08587-x
chicago: Schultz, Kollin, Pedro Costa-Pinheiro, Lauren Gardner, Laura V. Pinheiro,
Julio Ramirez-Solis, Sarah M. Gardner, Kathryn E. Wellen, and Ronen Marmorstein.
“Snapshots of Acyl Carrier Protein Shuttling in Human Fatty Acid Synthase.” Nature.
Springer Nature, 2025. https://doi.org/10.1038/s41586-025-08587-x.
ieee: K. Schultz et al., “Snapshots of acyl carrier protein shuttling in
human fatty acid synthase,” Nature, vol. 641, no. 8062. Springer Nature,
pp. 520–528, 2025.
ista: Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner
SM, Wellen KE, Marmorstein R. 2025. Snapshots of acyl carrier protein shuttling
in human fatty acid synthase. Nature. 641(8062), 520–528.
mla: Schultz, Kollin, et al. “Snapshots of Acyl Carrier Protein Shuttling in Human
Fatty Acid Synthase.” Nature, vol. 641, no. 8062, Springer Nature, 2025,
pp. 520–28, doi:10.1038/s41586-025-08587-x.
short: K. Schultz, P. Costa-Pinheiro, L. Gardner, L.V. Pinheiro, J. Ramirez-Solis,
S.M. Gardner, K.E. Wellen, R. Marmorstein, Nature 641 (2025) 520–528.
date_created: 2026-05-24T08:25:19Z
date_published: 2025-05-08T00:00:00Z
date_updated: 2026-06-02T14:57:52Z
day: '08'
ddc:
- '572'
doi: 10.1038/s41586-025-08587-x
extern: '1'
external_id:
pmid:
- '39979457 '
fulldoi: https://doi.org/10.1038/s41586-025-08587-x
has_accepted_license: '1'
intvolume: ' 641'
issue: '8062'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41586-025-08587-x
month: '05'
oa: 1
oa_version: Published Version
page: 520-528
pmid: 1
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Snapshots of acyl carrier protein shuttling in human fatty acid synthase
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 641
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '19421'
abstract:
- lang: eng
text: The phytohormone auxin (Aux) is a principal endogenous developmental signal
in plants. It mediates transcriptional reprogramming by a well-established canonical
signalling mechanism. TIR1/AFB auxin receptors are F-box subunits of an ubiquitin
ligase complex; after auxin perception, they associate with Aux/IAA transcriptional
repressors and ubiquitinate them for degradation, thus enabling the activation
of auxin response factor (ARF) transcription factors1,2,3. Here we revise this
paradigm by showing that without TIR1 adenylate cyclase (AC) activity4, auxin-induced
degradation of Aux/IAAs is not sufficient to mediate the transcriptional auxin
response. Abolishing the TIR1 AC activity does not affect auxin-induced degradation
of Aux/IAAs but renders TIR1 non-functional in mediating transcriptional reprogramming
and auxin-regulated development, including shoot, root, root hair growth and lateral
root formation. Transgenic plants show that local cAMP production in the vicinity
of the Aux/IAA–ARF complex by unrelated AC enzymes bypasses the need for auxin
perception and is sufficient to induce ARF-mediated transcription. These discoveries
revise the canonical model of auxin signalling and establish TIR1/AFB-produced
cAMP as a second messenger essential for transcriptional reprograming.
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
acknowledgement: We are grateful to J. Callis and H.-Q. Yang for sharing materials
and to M. Estelle and S. Kepinski for inspiring discussions. This research was supported
by the Laboratory Support Facility, the Plant Facility and the Imaging and Optics
Facility of the Institute of Science and Technology Austria. This project has received
funding from the European Research Council (101142681 CYNIPS) and Austrian Science
Fund (P 37051-B). L.Q. was supported by the National Natural Science Foundation
of China (grant no. 32470327). M.Z. was supported by the Interdisciplinary Project
Committee of the Institute of Science and Technology Austria, and Y.P. was supported
by an EMBO Postdoctoral Fellowship (ALTF 38-2023). Open access funding provided
by Institute of Science and Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Huihuang
full_name: Chen, Huihuang
id: 83c96512-15b2-11ec-abd3-b7eede36184f
last_name: Chen
- first_name: Linlin
full_name: Qi, Linlin
id: 44B04502-A9ED-11E9-B6FC-583AE6697425
last_name: Qi
orcid: 0000-0001-5187-8401
- first_name: Minxia
full_name: Zou, Minxia
id: 5c243f41-03f3-11ec-841c-96faf48a7ef9
last_name: Zou
- first_name: Mengting
full_name: Lu, Mengting
id: a8198a14-1ffe-11ee-8b67-d2bdff9d9178
last_name: Lu
- first_name: M
full_name: Kwiatkowski, M
last_name: Kwiatkowski
- first_name: Yuanrong
full_name: Pei, Yuanrong
id: 98605edc-6ce7-11ee-95f3-cc16b866efcd
last_name: Pei
- first_name: K
full_name: Jaworski, K
last_name: Jaworski
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Chen H, Qi L, Zou M, et al. TIR1-produced cAMP as a second messenger in transcriptional
auxin signalling. Nature. 2025;640:1011-1016. doi:10.1038/s41586-025-08669-w
apa: Chen, H., Qi, L., Zou, M., Lu, M., Kwiatkowski, M., Pei, Y., … Friml, J. (2025).
TIR1-produced cAMP as a second messenger in transcriptional auxin signalling.
Nature. Springer Nature. https://doi.org/10.1038/s41586-025-08669-w
chicago: Chen, Huihuang, Linlin Qi, Minxia Zou, Mengting Lu, M Kwiatkowski, Yuanrong
Pei, K Jaworski, and Jiří Friml. “TIR1-Produced CAMP as a Second Messenger in
Transcriptional Auxin Signalling.” Nature. Springer Nature, 2025. https://doi.org/10.1038/s41586-025-08669-w.
ieee: H. Chen et al., “TIR1-produced cAMP as a second messenger in transcriptional
auxin signalling,” Nature, vol. 640. Springer Nature, pp. 1011–1016, 2025.
ista: Chen H, Qi L, Zou M, Lu M, Kwiatkowski M, Pei Y, Jaworski K, Friml J. 2025.
TIR1-produced cAMP as a second messenger in transcriptional auxin signalling.
Nature. 640, 1011–1016.
mla: Chen, Huihuang, et al. “TIR1-Produced CAMP as a Second Messenger in Transcriptional
Auxin Signalling.” Nature, vol. 640, Springer Nature, 2025, pp. 1011–16,
doi:10.1038/s41586-025-08669-w.
short: H. Chen, L. Qi, M. Zou, M. Lu, M. Kwiatkowski, Y. Pei, K. Jaworski, J. Friml,
Nature 640 (2025) 1011–1016.
corr_author: '1'
date_created: 2025-03-19T09:44:39Z
date_published: 2025-04-24T00:00:00Z
date_updated: 2026-04-28T13:42:45Z
day: '24'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1038/s41586-025-08669-w
external_id:
isi:
- '001437493900001'
pmid:
- '40044868'
file:
- access_level: open_access
checksum: f5f18081003e7a1b8e372ecb7da82e7d
content_type: application/pdf
creator: dernst
date_created: 2025-08-05T12:29:35Z
date_updated: 2025-08-05T12:29:35Z
file_id: '20132'
file_name: 2025_Nature_Chen.pdf
file_size: 13549245
relation: main_file
success: 1
file_date_updated: 2025-08-05T12:29:35Z
fulldoi: https://doi.org/10.1038/s41586-025-08669-w
has_accepted_license: '1'
intvolume: ' 640'
isi: 1
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 1011-1016
pmid: 1
project:
- _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6
grant_number: P37051
name: Guanylate cyclase activity of TIR1/AFBs auxin receptors
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/updating-the-textbook/
record:
- id: '19478'
relation: dissertation_contains
status: public
status: public
title: TIR1-produced cAMP as a second messenger in transcriptional auxin signalling
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 640
year: '2025'
...
---
OA_type: closed access
_id: '19444'
abstract:
- lang: eng
text: As the field of neural organoids and assembloids expands, there is an emergent
need for guidance and advice on designing, conducting and reporting experiments
to increase the reproducibility and utility of these models. In this Perspective,
we present a framework for the experimental process that encompasses ensuring
the quality and integrity of human pluripotent stem cells, characterizing and
manipulating neural cells in vitro, transplantation techniques and considerations
for modelling human development, evolution and disease. As with all scientific
endeavours, we advocate for rigorous experimental designs tailored to explicit
scientific questions as well as transparent methodologies and data sharing to
provide useful knowledge for current research practices and for developing regulatory
standards.
acknowledgement: The authors thank members of their laboratories who provided feedback
on earlier versions of this manuscript, including A. Jourdon, V. Mariano, T. L.
Li, N. Caporale, E. Villa and M. Sutcliffe.
article_processing_charge: No
article_type: original
author:
- first_name: Sergiu P.
full_name: Pașca, Sergiu P.
last_name: Pașca
- first_name: Paola
full_name: Arlotta, Paola
last_name: Arlotta
- first_name: Helen S.
full_name: Bateup, Helen S.
last_name: Bateup
- first_name: J. Gray
full_name: Camp, J. Gray
last_name: Camp
- first_name: Silvia
full_name: Cappello, Silvia
last_name: Cappello
- first_name: Fred H.
full_name: Gage, Fred H.
last_name: Gage
- first_name: Jürgen A.
full_name: Knoblich, Jürgen A.
last_name: Knoblich
- first_name: Arnold R.
full_name: Kriegstein, Arnold R.
last_name: Kriegstein
- first_name: Madeline A.
full_name: Lancaster, Madeline A.
last_name: Lancaster
- first_name: Guo Li
full_name: Ming, Guo Li
last_name: Ming
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
- first_name: Hideyuki
full_name: Okano, Hideyuki
last_name: Okano
- first_name: Malin
full_name: Parmar, Malin
last_name: Parmar
- first_name: In Hyun
full_name: Park, In Hyun
last_name: Park
- first_name: Orly
full_name: Reiner, Orly
last_name: Reiner
- first_name: Hongjun
full_name: Song, Hongjun
last_name: Song
- first_name: Lorenz
full_name: Studer, Lorenz
last_name: Studer
- first_name: Jun
full_name: Takahashi, Jun
last_name: Takahashi
- first_name: Sally
full_name: Temple, Sally
last_name: Temple
- first_name: Giuseppe
full_name: Testa, Giuseppe
last_name: Testa
- first_name: Barbara
full_name: Treutlein, Barbara
last_name: Treutlein
- first_name: Flora M.
full_name: Vaccarino, Flora M.
last_name: Vaccarino
- first_name: Pierre
full_name: Vanderhaeghen, Pierre
last_name: Vanderhaeghen
- first_name: Tracy
full_name: Young-Pearse, Tracy
last_name: Young-Pearse
citation:
ama: Pașca SP, Arlotta P, Bateup HS, et al. A framework for neural organoids, assembloids
and transplantation studies. Nature. 2025;639(8054):315-320. doi:10.1038/s41586-024-08487-6
apa: Pașca, S. P., Arlotta, P., Bateup, H. S., Camp, J. G., Cappello, S., Gage,
F. H., … Young-Pearse, T. (2025). A framework for neural organoids, assembloids
and transplantation studies. Nature. Springer Nature. https://doi.org/10.1038/s41586-024-08487-6
chicago: Pașca, Sergiu P., Paola Arlotta, Helen S. Bateup, J. Gray Camp, Silvia
Cappello, Fred H. Gage, Jürgen A. Knoblich, et al. “A Framework for Neural Organoids,
Assembloids and Transplantation Studies.” Nature. Springer Nature, 2025.
https://doi.org/10.1038/s41586-024-08487-6.
ieee: S. P. Pașca et al., “A framework for neural organoids, assembloids
and transplantation studies,” Nature, vol. 639, no. 8054. Springer Nature,
pp. 315–320, 2025.
ista: Pașca SP, Arlotta P, Bateup HS, Camp JG, Cappello S, Gage FH, Knoblich JA,
Kriegstein AR, Lancaster MA, Ming GL, Novarino G, Okano H, Parmar M, Park IH,
Reiner O, Song H, Studer L, Takahashi J, Temple S, Testa G, Treutlein B, Vaccarino
FM, Vanderhaeghen P, Young-Pearse T. 2025. A framework for neural organoids, assembloids
and transplantation studies. Nature. 639(8054), 315–320.
mla: Pașca, Sergiu P., et al. “A Framework for Neural Organoids, Assembloids and
Transplantation Studies.” Nature, vol. 639, no. 8054, Springer Nature,
2025, pp. 315–20, doi:10.1038/s41586-024-08487-6.
short: S.P. Pașca, P. Arlotta, H.S. Bateup, J.G. Camp, S. Cappello, F.H. Gage, J.A.
Knoblich, A.R. Kriegstein, M.A. Lancaster, G.L. Ming, G. Novarino, H. Okano, M.
Parmar, I.H. Park, O. Reiner, H. Song, L. Studer, J. Takahashi, S. Temple, G.
Testa, B. Treutlein, F.M. Vaccarino, P. Vanderhaeghen, T. Young-Pearse, Nature
639 (2025) 315–320.
date_created: 2025-03-23T23:01:27Z
date_published: 2025-03-13T00:00:00Z
date_updated: 2025-09-30T11:13:47Z
day: '13'
department:
- _id: GaNo
doi: 10.1038/s41586-024-08487-6
external_id:
isi:
- '001437461900001'
pmid:
- '39653126'
fulldoi: https://doi.org/10.1038/s41586-024-08487-6
intvolume: ' 639'
isi: 1
issue: '8054'
language:
- iso: eng
month: '03'
oa_version: None
page: 315-320
pmid: 1
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: A framework for neural organoids, assembloids and transplantation studies
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 639
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '19704'
abstract:
- lang: eng
text: The information-processing capability of the brain’s cellular network depends
on the physical wiring pattern between neurons and their molecular and functional
characteristics. Mapping neurons and resolving their individual synaptic connections
can be achieved by volumetric imaging at nanoscale resolution1,2 with dense cellular
labelling. Light microscopy is uniquely positioned to visualize specific molecules,
but dense, synapse-level circuit reconstruction by light microscopy has been out
of reach, owing to limitations in resolution, contrast and volumetric imaging
capability. Here we describe light-microscopy-based connectomics (LICONN). We
integrated specifically engineered hydrogel embedding and expansion with comprehensive
deep-learning-based segmentation and analysis of connectivity, thereby directly
incorporating molecular information into synapse-level reconstructions of brain
tissue. LICONN will allow synapse-level phenotyping of brain tissue in biological
experiments in a readily adoptable manner.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: ScienComp
- _id: PreCl
- _id: M-Shop
- _id: E-Lib
acknowledgement: 'We thank S. Dorkenwald and P. Li for critical reading of the manuscript,
S. Loomba for discussions and E. Miguel for support with data handling. We acknowledge
support from ISTA’s scientific service units: Imaging and Optics, Lab Support, Scientific
Computing, the preclinical facility, the Miba Machine Shop and the library. We acknowledge
funding from the following sources: Austrian Science Fund (FWF) grant DK W1232 (J.G.D.
and M.R.T.); Austrian Academy of Sciences DOC fellowship 26137 (M.R.T.); Gesellschaft
für Forschungsförderung NÖ (NFB) grant LSC18-022 (J.G.D.); the European Union’s
Horizon 2020 research and innovation programme and Marie Skłodowska-Curie Actions
Fellowship 665385 (J.L.); and the European Union’s Horizon 2020 research and innovation
programme and European Research Council (ERC) grant 101044865 ‘SecretAutism’ (G.N.).Open
access funding provided by Institute of Science and Technology (IST Austria).'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Mojtaba
full_name: Tavakoli, Mojtaba
id: 3A0A06F4-F248-11E8-B48F-1D18A9856A87
last_name: Tavakoli
orcid: 0000-0002-7667-6854
- first_name: Julia
full_name: Lyudchik, Julia
id: 46E28B80-F248-11E8-B48F-1D18A9856A87
last_name: Lyudchik
- first_name: Michał
full_name: Januszewski, Michał
last_name: Januszewski
- first_name: Vitali
full_name: Vistunou, Vitali
id: 7e146587-8972-11ed-ae7b-d7a32ea86a81
last_name: Vistunou
- first_name: Nathalie
full_name: Agudelo Duenas, Nathalie
id: 40E7F008-F248-11E8-B48F-1D18A9856A87
last_name: Agudelo Duenas
- first_name: Jakob
full_name: Vorlaufer, Jakob
id: 937696FA-C996-11E9-8C7C-CF13E6697425
last_name: Vorlaufer
orcid: 0009-0000-7590-3501
- first_name: Christoph M
full_name: Sommer, Christoph M
id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
last_name: Sommer
orcid: 0000-0003-1216-9105
- first_name: Caroline
full_name: Kreuzinger, Caroline
id: 382077BA-F248-11E8-B48F-1D18A9856A87
last_name: Kreuzinger
- first_name: Bárbara
full_name: Oliveira, Bárbara
id: 3B03AA1A-F248-11E8-B48F-1D18A9856A87
last_name: Oliveira
- first_name: Alban
full_name: Cenameri, Alban
id: 9ac8f577-2357-11eb-997a-e566c5550886
last_name: Cenameri
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
- first_name: Viren
full_name: Jain, Viren
last_name: Jain
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
citation:
ama: Tavakoli M, Lyudchik J, Januszewski M, et al. Light-microscopy-based connectomic
reconstruction of mammalian brain tissue. Nature. 2025;642:398-410. doi:10.1038/s41586-025-08985-1
apa: Tavakoli, M., Lyudchik, J., Januszewski, M., Vistunou, V., Agudelo Duenas,
N., Vorlaufer, J., … Danzl, J. G. (2025). Light-microscopy-based connectomic reconstruction
of mammalian brain tissue. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-08985-1
chicago: Tavakoli, Mojtaba, Julia Lyudchik, Michał Januszewski, Vitali Vistunou,
Nathalie Agudelo Duenas, Jakob Vorlaufer, Christoph M Sommer, et al. “Light-Microscopy-Based
Connectomic Reconstruction of Mammalian Brain Tissue.” Nature. Springer
Nature, 2025. https://doi.org/10.1038/s41586-025-08985-1.
ieee: M. Tavakoli et al., “Light-microscopy-based connectomic reconstruction
of mammalian brain tissue,” Nature, vol. 642. Springer Nature, pp. 398–410,
2025.
ista: Tavakoli M, Lyudchik J, Januszewski M, Vistunou V, Agudelo Duenas N, Vorlaufer
J, Sommer CM, Kreuzinger C, Oliveira B, Cenameri A, Novarino G, Jain V, Danzl
JG. 2025. Light-microscopy-based connectomic reconstruction of mammalian brain
tissue. Nature. 642, 398–410.
mla: Tavakoli, Mojtaba, et al. “Light-Microscopy-Based Connectomic Reconstruction
of Mammalian Brain Tissue.” Nature, vol. 642, Springer Nature, 2025, pp.
398–410, doi:10.1038/s41586-025-08985-1.
short: M. Tavakoli, J. Lyudchik, M. Januszewski, V. Vistunou, N. Agudelo Duenas,
J. Vorlaufer, C.M. Sommer, C. Kreuzinger, B. Oliveira, A. Cenameri, G. Novarino,
V. Jain, J.G. Danzl, Nature 642 (2025) 398–410.
corr_author: '1'
date_created: 2025-05-18T22:02:51Z
date_published: 2025-06-12T00:00:00Z
date_updated: 2026-04-28T13:33:34Z
day: '12'
ddc:
- '570'
department:
- _id: JoDa
- _id: GradSch
- _id: Bio
- _id: GaNo
doi: 10.1038/s41586-025-08985-1
ec_funded: 1
external_id:
isi:
- '001483477000001'
pmid:
- '40335689'
file:
- access_level: open_access
checksum: ebc99d7108e728f46db0a009292675ef
content_type: application/pdf
creator: dernst
date_created: 2025-07-03T06:55:20Z
date_updated: 2025-07-03T06:55:20Z
file_id: '19959'
file_name: 2025_Nature_Tavakoli.pdf
file_size: 133201290
relation: main_file
success: 1
file_date_updated: 2025-07-03T06:55:20Z
fulldoi: https://doi.org/10.1038/s41586-025-08985-1
has_accepted_license: '1'
intvolume: ' 642'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 398-410
pmid: 1
project:
- _id: 6285a163-2b32-11ec-9570-8e204ca2dba5
grant_number: '26137'
name: Studying Organelle Structure and Function at Nanoscale Resolution with Expansion
Microscopy
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 34ba8964-11ca-11ed-8bc3-e15864e7e9a6
grant_number: '101044865'
name: Toward an understanding of the brain interstitial system and the extracellular
proteome in health and autism spectrum disorders
- _id: 26AA4EF2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232-B24
name: Molecular Drug Targets
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/piecing-together-the-brain-puzzle/
record:
- id: '18677'
relation: earlier_version
status: public
- id: '18697'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Light-microscopy-based connectomic reconstruction of mammalian brain tissue
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 642
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20430'
abstract:
- lang: eng
text: Protein design has focused on the design of ground states, ensuring that they
are sufficiently low energy to be highly populated1. Designing the kinetics and
dynamics of a system requires, in addition, the design of excited states that
are traversed in transitions from one low-lying state to another2,3. This is a
challenging task because such states must be sufficiently strained to be poorly
populated, but not so strained that they are not populated at all, and because
protein design methods have focused on generating near-ideal structures4,5,6,7.
Here we describe a general approach for designing systems that use an induced-fit
power stroke8 to generate a structurally frustrated9 and strained excited state,
allosterically driving protein complex dissociation. X-ray crystallography, double
electron–electron resonance spectroscopy and kinetic binding measurements show
that incorporating excited states enables the design of effector-induced increases
in dissociation rates as high as 5,700-fold. We highlight the power of this approach
by designing rapid biosensors, kinetically controlled circuits and cytokine mimics
that can be dissociated from their receptors within seconds, enabling dissection
of the temporal dynamics of interleukin-2 signalling.
acknowledgement: We thank P. J. Y. Leung, K. L. Shelley, A. Pillai, C. Demakis, M.
Exposit, K. Thompson, C. Savvides, R. J. Ragotte, G. Ahn and M. Glögl for discussions
and technical support; K. VanWormer and L. Goldschmidt for technical support; S.
R. Gerben and A. Murray for protein production support; and X. Li, M. Lamb, Z. Taylor
and V. Adebomi for LC–MS support. This work was supported by the Audacious Project
at the Institute for Protein Design (A.J.B., A.K., J.D.L.C., E.B. and A.K.B.); by
a gift from Microsoft (A.J.B.); by the Nordstrom Barrier Institute for Protein Design
Directors Fund (M.H.A. and F.P.); by Bill and Melinda Gates Foundation OPP1156262
(A.K. and J.D.L.C.); by the Open Philanthropy Project Improving Protein Design Fund
(E.B. and A.K.B.); by the National Institutes of Health (NIH) National Institute
of Allergy and Infectious Disease grant R0AI160052 (A.K.B.); by CRI Irvington Postdoctoral
Fellowship 315511 (Y.Z.); by National Cancer Institute K00 award 4K00CA274708 (M.O.);
by National Science Foundation grant MCB 2119837 and NIH grant GM115805 (W.H.R.
and D.M.Z.); by NIH grant GM151956 (S.S.); by NIH AI-51321 (K.C.G.); by the DFG
grants PI 405/15 and SFB 1557 (C.P. and J.P.); and by the Howard Hughes Medical
Institute (A.K.B., K.C.G. and D.B.). The EPR spectrometer used for the DEER experiments
was in part supported by NIH grant S10OD021557. This research used resources (FMX/AMX)
of the National Synchrotron Light Source II, a US Department of Energy (DoE) Office
of Science User Facility operated for the DOE Office of Science by Brookhaven National
Laboratory under contract DE-SC0012704. The Center for BioMolecular Structure (CBMS)
is supported mainly by the NIH National Institute of General Medical Sciences (NIGMS)
through a Center Core P30 Grant (P30GM133893), and by the DoE Office of Biological
and Environmental Research (KP1607011). This work is based on research performed
at the Northeastern Collaborative Access Team beamlines, which are funded by the
NIGMS (P30 GM124165). The research used resources of the Advanced Photon Source,
a US DoE Office of Science User Facility operated for the DoE Office of Science
by Argonne National Laboratory under contract DE-AC02-06CH11357. The Berkeley Center
for Structural Biology is supported by the NIH, NIGMS and the Howard Hughes Medical
Institute. The Advanced Light Source is supported by the Director, Office of Science,
Office of Basic Energy Sciences and US DoE (DE-AC02-05CH11231).
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Adam J.
full_name: Broerman, Adam J.
last_name: Broerman
- first_name: Christoph
full_name: Pollmann, Christoph
last_name: Pollmann
- first_name: Yang
full_name: Zhao, Yang
last_name: Zhao
- first_name: Mauriz A.
full_name: Lichtenstein, Mauriz A.
last_name: Lichtenstein
- first_name: Mark D.
full_name: Jackson, Mark D.
last_name: Jackson
- first_name: Maxx H.
full_name: Tessmer, Maxx H.
last_name: Tessmer
- first_name: Won Hee
full_name: Ryu, Won Hee
last_name: Ryu
- first_name: Masato
full_name: Ogishi, Masato
last_name: Ogishi
- first_name: Mohamad H.
full_name: Abedi, Mohamad H.
last_name: Abedi
- first_name: Danny D.
full_name: Sahtoe, Danny D.
last_name: Sahtoe
- first_name: Aza
full_name: Allen, Aza
last_name: Allen
- first_name: Alex
full_name: Kang, Alex
last_name: Kang
- first_name: Joshmyn
full_name: De La Cruz, Joshmyn
last_name: De La Cruz
- first_name: Evans
full_name: Brackenbrough, Evans
last_name: Brackenbrough
- first_name: Banumathi
full_name: Sankaran, Banumathi
last_name: Sankaran
- first_name: Asim K.
full_name: Bera, Asim K.
last_name: Bera
- first_name: Daniel M.
full_name: Zuckerman, Daniel M.
last_name: Zuckerman
- first_name: Stefan
full_name: Stoll, Stefan
last_name: Stoll
- first_name: K. Christopher
full_name: Garcia, K. Christopher
last_name: Garcia
- first_name: Florian M
full_name: Praetorius, Florian M
id: dfec9381-4341-11ee-8fd8-faa02bba7d62
last_name: Praetorius
orcid: 0000-0002-0806-8101
- first_name: Jacob
full_name: Piehler, Jacob
last_name: Piehler
- first_name: David
full_name: Baker, David
last_name: Baker
citation:
ama: Broerman AJ, Pollmann C, Zhao Y, et al. Design of facilitated dissociation
enables timing of cytokine signalling. Nature. 2025;647:528-535. doi:10.1038/s41586-025-09549-z
apa: Broerman, A. J., Pollmann, C., Zhao, Y., Lichtenstein, M. A., Jackson, M. D.,
Tessmer, M. H., … Baker, D. (2025). Design of facilitated dissociation enables
timing of cytokine signalling. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-09549-z
chicago: Broerman, Adam J., Christoph Pollmann, Yang Zhao, Mauriz A. Lichtenstein,
Mark D. Jackson, Maxx H. Tessmer, Won Hee Ryu, et al. “Design of Facilitated Dissociation
Enables Timing of Cytokine Signalling.” Nature. Springer Nature, 2025.
https://doi.org/10.1038/s41586-025-09549-z.
ieee: A. J. Broerman et al., “Design of facilitated dissociation enables
timing of cytokine signalling,” Nature, vol. 647. Springer Nature, pp.
528–535, 2025.
ista: Broerman AJ, Pollmann C, Zhao Y, Lichtenstein MA, Jackson MD, Tessmer MH,
Ryu WH, Ogishi M, Abedi MH, Sahtoe DD, Allen A, Kang A, De La Cruz J, Brackenbrough
E, Sankaran B, Bera AK, Zuckerman DM, Stoll S, Garcia KC, Praetorius FM, Piehler
J, Baker D. 2025. Design of facilitated dissociation enables timing of cytokine
signalling. Nature. 647, 528–535.
mla: Broerman, Adam J., et al. “Design of Facilitated Dissociation Enables Timing
of Cytokine Signalling.” Nature, vol. 647, Springer Nature, 2025, pp. 528–35,
doi:10.1038/s41586-025-09549-z.
short: A.J. Broerman, C. Pollmann, Y. Zhao, M.A. Lichtenstein, M.D. Jackson, M.H.
Tessmer, W.H. Ryu, M. Ogishi, M.H. Abedi, D.D. Sahtoe, A. Allen, A. Kang, J. De
La Cruz, E. Brackenbrough, B. Sankaran, A.K. Bera, D.M. Zuckerman, S. Stoll, K.C.
Garcia, F.M. Praetorius, J. Piehler, D. Baker, Nature 647 (2025) 528–535.
corr_author: '1'
date_created: 2025-10-05T22:01:36Z
date_published: 2025-11-13T00:00:00Z
date_updated: 2026-01-05T13:18:17Z
day: '13'
ddc:
- '570'
department:
- _id: FlPr
doi: 10.1038/s41586-025-09549-z
external_id:
isi:
- '001577755600001'
pmid:
- '40993395'
file:
- access_level: open_access
checksum: b4ec44134e2eb320a724dc29158dfda2
content_type: application/pdf
creator: dernst
date_created: 2026-01-05T13:17:47Z
date_updated: 2026-01-05T13:17:47Z
file_id: '20951'
file_name: 2025_Nature_Broerman.pdf
file_size: 22099921
relation: main_file
success: 1
file_date_updated: 2026-01-05T13:17:47Z
fulldoi: https://doi.org/10.1038/s41586-025-09549-z
has_accepted_license: '1'
intvolume: ' 647'
isi: 1
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 528-535
pmid: 1
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Design of facilitated dissociation enables timing of cytokine signalling
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 647
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
_id: '20101'
abstract:
- lang: eng
text: 'Evading imminent threat from predators is critical for animal survival. Effective
defensive strategies can vary, even between closely related species. However,
the neural basis of such species-specific behaviours remains poorly understood1,2,3,4.
Here we find that two sister species of deer mice (genus Peromyscus)5 show different
responses to the same looming stimulus: Peromyscus maniculatus, which occupies
densely vegetated habitats, predominantly escapes, whereas the open field specialist,
Peromyscus polionotus, briefly freezes. This difference arises from species-specific
escape thresholds, is largely context-independent, and can be triggered by both
visual and auditory threat stimuli. Using immunohistochemistry and electrophysiological
recordings, we find that although visual threat activates the superior colliculus
in both species, the role of the dorsal periaqueductal grey (dPAG) in driving
behaviour differs. Whereas dPAG activity scales with running speed in P. maniculatus,
neural activity in the dPAG of P. polionotus correlates poorly with movement,
including during visually triggered escape. Moreover, optogenetic activation of
dPAG neurons elicits acceleration in P. maniculatus but not in P. polionotus,
and their chemogenetic inhibition during a looming stimulus delays escape onset
in P. maniculatus to match that of P. polionotus. Together, we trace species-specific
escape thresholds to a central circuit node, downstream of peripheral sensory
neurons, localizing an ecologically relevant behavioural difference to a specific
region of the mammalian brain.'
acknowledgement: The authors thank M. Yilmaz, M. Meister, M. Joesch and T. Branco
for advice on the behavioural experiments; C. Dulac, V. Bitsikas, E. Diel and J.
Chen for advice on the immunohistochemistry and RNAscope experiments; J. Greenwood
and E. Soucy for technical and engineering help; A. Chrzanowska for help and advice
on optogenetic experiments; A. Calzoni for help aligning histological sections to
a brain atlas; S. Worthington for statistical advice; P. Gonçalves for advice with
the electrophysiology analysis; I. Vlaemick for help with whole cell experiments;
R. Hellmiss for figure design; B. Sabatini, V. Stempel, K. Tyssowski and N. Sanguinetti
for feedback on the manuscript; and Y. M. Lee and A. Tomcho for photos of P. maniculatus
and P. leucopus habitats (Fig. 1). F.B. was supported by an HHMI International Student
Research Fellowship, a Grant-in-Aid of the American Society of Mammalogy, a Herchel
Smith Graduate Fellowship, a Robert A. Chapman Memorial Scholarship, and a Joan
Brockman Williamson Fellowship. This project received funding from the European
Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie
grant agreement 665501 and by the FWO (12S7917N and 12S7920N) to K.R. and from European
Research Council (ERC) (grant agreement 101075848) to K.R. V.T. was supported by
a Harvard PRISE fellowship and a Harvard Museum of Comparative Zoology grant for
undergraduate research. K.F. is supported by the FWO (G094616N and G091719N) and
the NIH (1R01EY032101). This work was supported by the Howard Hughes Medical Institute,
of which H.E.H. was an Investigator.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Felix
full_name: Baier, Felix
last_name: Baier
- first_name: Katja
full_name: Reinhard, Katja
last_name: Reinhard
- first_name: Bram
full_name: Nuttin, Bram
last_name: Nuttin
- first_name: Arnau
full_name: Sans-Dublanc, Arnau
last_name: Sans-Dublanc
- first_name: Chen
full_name: Liu, Chen
last_name: Liu
- first_name: Victoria
full_name: Tong, Victoria
last_name: Tong
- first_name: Julie Stefanie
full_name: Murmann, Julie Stefanie
id: 1d390868-f128-11eb-9611-a0ca5f7833b5
last_name: Murmann
- first_name: Keimpe
full_name: Wierda, Keimpe
last_name: Wierda
- first_name: Karl
full_name: Farrow, Karl
last_name: Farrow
- first_name: Hopi E.
full_name: Hoekstra, Hopi E.
last_name: Hoekstra
citation:
ama: Baier F, Reinhard K, Nuttin B, et al. The neural basis of species-specific
defensive behaviour in Peromyscus mice. Nature. 2025;645:439-447. doi:10.1038/s41586-025-09241-2
apa: Baier, F., Reinhard, K., Nuttin, B., Sans-Dublanc, A., Liu, C., Tong, V., …
Hoekstra, H. E. (2025). The neural basis of species-specific defensive behaviour
in Peromyscus mice. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-09241-2
chicago: Baier, Felix, Katja Reinhard, Bram Nuttin, Arnau Sans-Dublanc, Chen Liu,
Victoria Tong, Julie Stefanie Murmann, Keimpe Wierda, Karl Farrow, and Hopi E.
Hoekstra. “The Neural Basis of Species-Specific Defensive Behaviour in Peromyscus
Mice.” Nature. Springer Nature, 2025. https://doi.org/10.1038/s41586-025-09241-2.
ieee: F. Baier et al., “The neural basis of species-specific defensive behaviour
in Peromyscus mice,” Nature, vol. 645. Springer Nature, pp. 439–447, 2025.
ista: Baier F, Reinhard K, Nuttin B, Sans-Dublanc A, Liu C, Tong V, Murmann JS,
Wierda K, Farrow K, Hoekstra HE. 2025. The neural basis of species-specific defensive
behaviour in Peromyscus mice. Nature. 645, 439–447.
mla: Baier, Felix, et al. “The Neural Basis of Species-Specific Defensive Behaviour
in Peromyscus Mice.” Nature, vol. 645, Springer Nature, 2025, pp. 439–47,
doi:10.1038/s41586-025-09241-2.
short: F. Baier, K. Reinhard, B. Nuttin, A. Sans-Dublanc, C. Liu, V. Tong, J.S.
Murmann, K. Wierda, K. Farrow, H.E. Hoekstra, Nature 645 (2025) 439–447.
date_created: 2025-08-03T22:01:31Z
date_published: 2025-07-23T00:00:00Z
date_updated: 2026-07-22T06:20:09Z
day: '23'
ddc:
- '570'
department:
- _id: GradSch
doi: 10.1038/s41586-025-09241-2
external_id:
pmid:
- '40702175'
file:
- access_level: open_access
checksum: 7ea846a7a49b3b2a248f6a27ab13d591
content_type: application/pdf
creator: dernst
date_created: 2025-12-30T07:39:45Z
date_updated: 2025-12-30T07:39:45Z
file_id: '20884'
file_name: 2025_Nature_Baier.pdf
file_size: 53301589
relation: main_file
success: 1
file_date_updated: 2025-12-30T07:39:45Z
fulldoi: https://doi.org/10.1038/s41586-025-09241-2
has_accepted_license: '1'
intvolume: ' 645'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 439-447
pmid: 1
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '20883'
relation: research_data
status: public
scopus_import: '1'
status: public
title: The neural basis of species-specific defensive behaviour in Peromyscus mice
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 645
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
_id: '19278'
abstract:
- lang: eng
text: 'When two insulating, neutral materials are contacted and separated, they
exchange electrical charge1. Experiments have long suggested that this ‘contact
electrification’ is transitive, with different materials ordering into ‘triboelectric
series’ based on the sign of charge acquired2. At the same time, the effect is
plagued by unpredictability, preventing consensus on the mechanism and casting
doubt on the rhyme and reason that series imply3. Here we expose an unanticipated
connection between the unpredictability and order in contact electrification:
nominally identical materials initially exchange charge randomly and intransitively,
but—over repeated experiments—order into triboelectric series. We find that this
evolution is driven by the act of contact itself—samples with more contacts in
their history charge negatively to ones with fewer contacts. Capturing this ‘contact
bias’ in a minimal model, we recreate both the initial randomness and ultimate
order in numerical simulations and use it experimentally to force the appearance
of a triboelectric series of our choosing. With a set of surface-sensitive techniques
to search for the underlying alterations contact creates, we only find evidence
of nanoscale morphological changes, pointing to a mechanism strongly coupled with
mechanics. Our results highlight the centrality of contact history in contact
electrification and suggest that focusing on the unpredictability that has long
plagued the effect may hold the key to understanding it.'
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
- _id: ScienComp
- _id: EM-Fac
- _id: LifeSc
acknowledgement: This project has received financing from the European Research Council
grant agreement no. 949120 under the European Union’s Horizon 2020 research and
innovation programme. The Analytical Instrumentation Center of the TU Wien acknowledges
support by the FFG project ‘ELSA’ under grant no. 884672. C.M.P. and M.O. acknowledge
the state of Lower Austria and the European Regional Development Fund under grant
no. WST3-F-542638/004-2021. This research was supported by the Scientific Service
Units of the Institute of Science and Technology Austria through resources provided
by the Miba Machine Shop, Nanofabrication Facility, Scientific Computing facility,
Electron Microscopy Facility and Lab Support Facility. We thank J. Garcia-Suarez
and G. Anciaux for the suggestion to look into the roughness power spectral density.
We thank I.-M. Strugaru for help with testing the device for Young’s modulus measurements.
Open access funding provided by Institute of Science and Technology (IST Austria).
article_number: 664-669
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Juan Carlos A
full_name: Sobarzo Ponce, Juan Carlos A
id: 4B807D68-AE37-11E9-AC72-31CAE5697425
last_name: Sobarzo Ponce
- first_name: Felix
full_name: Pertl, Felix
id: 6313aec0-15b2-11ec-abd3-ed67d16139af
last_name: Pertl
orcid: 0000-0003-0463-5794
- first_name: Daniel
full_name: Balazs, Daniel
id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E
last_name: Balazs
orcid: 0000-0001-7597-043X
- first_name: Tommaso
full_name: Costanzo, Tommaso
id: D93824F4-D9BA-11E9-BB12-F207E6697425
last_name: Costanzo
orcid: 0000-0001-9732-3815
- first_name: Markus
full_name: Sauer, Markus
last_name: Sauer
- first_name: Annette
full_name: Foelske, Annette
last_name: Foelske
- first_name: Markus
full_name: Ostermann, Markus
last_name: Ostermann
- first_name: Christian M.
full_name: Pichler, Christian M.
last_name: Pichler
- first_name: Yongkang
full_name: Wang, Yongkang
last_name: Wang
- first_name: Yuki
full_name: Nagata, Yuki
last_name: Nagata
- first_name: Mischa
full_name: Bonn, Mischa
last_name: Bonn
- first_name: Scott R
full_name: Waitukaitis, Scott R
id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87
last_name: Waitukaitis
orcid: 0000-0002-2299-3176
citation:
ama: Sobarzo Ponce JCA, Pertl F, Balazs D, et al. Spontaneous ordering of identical
materials into a triboelectric series. Nature. 2025;638(8051). doi:10.1038/s41586-024-08530-6
apa: Sobarzo Ponce, J. C. A., Pertl, F., Balazs, D., Costanzo, T., Sauer, M., Foelske,
A., … Waitukaitis, S. R. (2025). Spontaneous ordering of identical materials into
a triboelectric series. Nature. Springer Nature. https://doi.org/10.1038/s41586-024-08530-6
chicago: Sobarzo Ponce, Juan Carlos A, Felix Pertl, Daniel Balazs, Tommaso Costanzo,
Markus Sauer, Annette Foelske, Markus Ostermann, et al. “Spontaneous Ordering
of Identical Materials into a Triboelectric Series.” Nature. Springer Nature,
2025. https://doi.org/10.1038/s41586-024-08530-6.
ieee: J. C. A. Sobarzo Ponce et al., “Spontaneous ordering of identical materials
into a triboelectric series,” Nature, vol. 638, no. 8051. Springer Nature,
2025.
ista: Sobarzo Ponce JCA, Pertl F, Balazs D, Costanzo T, Sauer M, Foelske A, Ostermann
M, Pichler CM, Wang Y, Nagata Y, Bonn M, Waitukaitis SR. 2025. Spontaneous ordering
of identical materials into a triboelectric series. Nature. 638(8051), 664–669.
mla: Sobarzo Ponce, Juan Carlos A., et al. “Spontaneous Ordering of Identical Materials
into a Triboelectric Series.” Nature, vol. 638, no. 8051, 664–669, Springer
Nature, 2025, doi:10.1038/s41586-024-08530-6.
short: J.C.A. Sobarzo Ponce, F. Pertl, D. Balazs, T. Costanzo, M. Sauer, A. Foelske,
M. Ostermann, C.M. Pichler, Y. Wang, Y. Nagata, M. Bonn, S.R. Waitukaitis, Nature
638 (2025).
corr_author: '1'
date_created: 2025-03-02T23:01:52Z
date_published: 2025-02-20T00:00:00Z
date_updated: 2026-08-27T11:42:43Z
day: '20'
ddc:
- '530'
department:
- _id: ScWa
- _id: LifeSc
- _id: EM-Fac
doi: 10.1038/s41586-024-08530-6
ec_funded: 1
external_id:
isi:
- '001428076100015'
pmid:
- '39972227'
file:
- access_level: open_access
checksum: fecf302274dd3218d3e7dd22f39a6c0c
content_type: application/pdf
creator: dernst
date_created: 2025-03-04T10:05:18Z
date_updated: 2025-03-04T10:05:18Z
file_id: '19289'
file_name: 2025_Nature_Sobarzo.pdf
file_size: 3807415
relation: main_file
success: 1
file_date_updated: 2025-03-04T10:05:18Z
fulldoi: https://doi.org/10.1038/s41586-024-08530-6
has_accepted_license: '1'
intvolume: ' 638'
isi: 1
issue: '8051'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 0aa60e99-070f-11eb-9043-a6de6bdc3afa
call_identifier: H2020
grant_number: '949120'
name: 'Tribocharge: a multi-scale approach to an enduring problem in physics'
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/an-electrifying-turn-in-an-age-old-quest/
record:
- id: '20203'
relation: dissertation_contains
status: public
- id: '22684'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Spontaneous ordering of identical materials into a triboelectric series
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 638
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '17468'
abstract:
- lang: eng
text: Oxygen redox chemistry is central to life1 and many human-made technologies,
such as in energy storage2,3,4. The large energy gain from oxygen redox reactions
is often connected with the occurrence of harmful reactive oxygen species3,5,6.
Key species are superoxide and the highly reactive singlet oxygen3,4,5,6,7, which
may evolve from superoxide. However, the factors determining the formation of
singlet oxygen, rather than the relatively unreactive triplet oxygen, are unknown.
Here we report that the release of triplet or singlet oxygen is governed by individual
Marcus normal and inverted region behaviour. We found that as the driving force
for the reaction increases, the initially dominant evolution of triplet oxygen
slows down, and singlet oxygen evolution becomes predominant with higher maximum
kinetics. This behaviour also applies to the widely observed superoxide disproportionation,
in which one superoxide is oxidized by another, in both non-aqueous and aqueous
systems, with Lewis and Brønsted acidity controlling the driving forces. Singlet
oxygen yields governed by these conditions are relevant, for example, in batteries
or cellular organelles in which superoxide forms. Our findings suggest ways to
understand and control spin states and kinetics in oxygen redox chemistry, with
implications for fields, including life sciences, pure chemistry and energy storage.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: M-Shop
- _id: ScienComp
acknowledgement: S.A.F. thanks the Institute of Science and Technology Austria (ISTA)
for the support. The Scientific Service Units of ISTA supported this research through
resources provided by the Imaging and Optics Facility, the Lab Support Facility,
the Miba Machine Shop and Scientific Computing. This research was partly funded
by the Austrian Science Fund (FWF) (10.55776/P37169 and 10.55776/COE5). For open
access purposes, the author has applied for a CC BY public copyright licence to
any author-accepted manuscript version arising from this submission. R.H. acknowledges
funding through CZI grant DAF2020-225401 (10.37921/120055ratwvi) from the Chan Zuckerberg
Initiative DAF, an advised fund of Silicon Valley Community Foundation (10.13039/100014989).
H.T.K.N. acknowledges funding by the European Commission Erasmus Mundus Joint Masters
programme. We thank M. Sixt and M. Chinon for the discussions about O-redox in life
and R. Jethwa for proofreading. Open access funding was provided by ISTA.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Soumyadip
full_name: Mondal, Soumyadip
id: d25d21ef-dc8d-11ea-abe3-ec4576307f48
last_name: Mondal
- first_name: Huyen T.K.
full_name: Nguyen, Huyen T.K.
last_name: Nguyen
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
citation:
ama: Mondal S, Nguyen HTK, Hauschild R, Freunberger SA. Marcus kinetics control
singlet and triplet oxygen evolving from superoxide. Nature. 2025;646(8085):601–605.
doi:10.1038/s41586-025-09587-7
apa: Mondal, S., Nguyen, H. T. K., Hauschild, R., & Freunberger, S. A. (2025).
Marcus kinetics control singlet and triplet oxygen evolving from superoxide. Nature.
Springer Nature. https://doi.org/10.1038/s41586-025-09587-7
chicago: Mondal, Soumyadip, Huyen T.K. Nguyen, Robert Hauschild, and Stefan Alexander
Freunberger. “Marcus Kinetics Control Singlet and Triplet Oxygen Evolving from
Superoxide.” Nature. Springer Nature, 2025. https://doi.org/10.1038/s41586-025-09587-7.
ieee: S. Mondal, H. T. K. Nguyen, R. Hauschild, and S. A. Freunberger, “Marcus kinetics
control singlet and triplet oxygen evolving from superoxide,” Nature, vol.
646, no. 8085. Springer Nature, pp. 601–605, 2025.
ista: Mondal S, Nguyen HTK, Hauschild R, Freunberger SA. 2025. Marcus kinetics control
singlet and triplet oxygen evolving from superoxide. Nature. 646(8085), 601–605.
mla: Mondal, Soumyadip, et al. “Marcus Kinetics Control Singlet and Triplet Oxygen
Evolving from Superoxide.” Nature, vol. 646, no. 8085, Springer Nature,
2025, pp. 601–605, doi:10.1038/s41586-025-09587-7.
short: S. Mondal, H.T.K. Nguyen, R. Hauschild, S.A. Freunberger, Nature 646 (2025)
601–605.
corr_author: '1'
date_created: 2024-08-29T10:40:23Z
date_published: 2025-10-16T00:00:00Z
date_updated: 2026-09-16T06:53:54Z
day: '16'
ddc:
- '540'
department:
- _id: StFr
- _id: Bio
doi: 10.1038/s41586-025-09587-7
external_id:
isi:
- '001586378900001'
pmid:
- '41044415'
file:
- access_level: open_access
checksum: b507ddd23df0388aa65d04dc9b00fe3d
content_type: application/pdf
creator: dernst
date_created: 2025-10-20T10:26:13Z
date_updated: 2025-10-20T10:26:13Z
file_id: '20500'
file_name: 2025_Nature_Mondal.pdf
file_size: 3809247
relation: main_file
success: 1
file_date_updated: 2025-10-20T10:26:13Z
fulldoi: https://doi.org/10.1038/s41586-025-09587-7
has_accepted_license: '1'
intvolume: ' 646'
isi: 1
issue: '8085'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 601–605
pmid: 1
project:
- _id: 8df062be-16d5-11f0-9cad-f559b6612c7e
grant_number: P37169
name: Singlet oxygen in non-aqueous oxygen redox chemistry
- _id: c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473
grant_number: CZI01
name: Tools for automation and feedback microscopy
- _id: 5eaf4378-b033-11f1-b276-f928018a46c1
grant_number: COE05
name: Materials for Energy Conversion and Storage (Freunberger)
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/taming-the-bad-oxygen/
scopus_import: '1'
status: public
title: Marcus kinetics control singlet and triplet oxygen evolving from superoxide
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 646
year: '2025'
...
---
OA_type: closed access
_id: '18616'
abstract:
- lang: eng
text: By patterning an ultrathin layered structure with tiny wells, physicists have
created and imaged peculiar states known as quantum scars — revealing behaviour
that could be used to boost the performance of electronic devices.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Dmitry
full_name: Abanin, Dmitry
last_name: Abanin
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
citation:
ama: Abanin D, Serbyn M. Quantum scars make their mark in graphene. Nature.
2024;635(8040):825-826. doi:10.1038/d41586-024-03649-y
apa: Abanin, D., & Serbyn, M. (2024). Quantum scars make their mark in graphene.
Nature. Springer Nature. https://doi.org/10.1038/d41586-024-03649-y
chicago: Abanin, Dmitry, and Maksym Serbyn. “Quantum Scars Make Their Mark in Graphene.”
Nature. Springer Nature, 2024. https://doi.org/10.1038/d41586-024-03649-y.
ieee: D. Abanin and M. Serbyn, “Quantum scars make their mark in graphene,” Nature,
vol. 635, no. 8040. Springer Nature, pp. 825–826, 2024.
ista: Abanin D, Serbyn M. 2024. Quantum scars make their mark in graphene. Nature.
635(8040), 825–826.
mla: Abanin, Dmitry, and Maksym Serbyn. “Quantum Scars Make Their Mark in Graphene.”
Nature, vol. 635, no. 8040, Springer Nature, 2024, pp. 825–26, doi:10.1038/d41586-024-03649-y.
short: D. Abanin, M. Serbyn, Nature 635 (2024) 825–826.
date_created: 2024-12-03T18:08:16Z
date_published: 2024-11-27T00:00:00Z
date_updated: 2025-09-08T14:57:35Z
day: '27'
department:
- _id: MaSe
doi: 10.1038/d41586-024-03649-y
external_id:
isi:
- '001367935000029'
pmid:
- '39604614'
fulldoi: https://doi.org/10.1038/d41586-024-03649-y
intvolume: ' 635'
isi: 1
issue: '8040'
language:
- iso: eng
month: '11'
oa_version: None
page: 825-826
pmid: 1
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Quantum scars make their mark in graphene
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 635
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '17442'
abstract:
- lang: eng
text: "Although eukaryotic Argonautes have a pivotal role in post-transcriptional
gene regulation through nucleic acid cleavage, some short prokaryotic Argonaute
variants (pAgos) rely on auxiliary nuclease factors for efficient foreign DNA
degradation1. Here we reveal the activation pathway of the DNA defence module
DdmDE system, which rapidly eliminates small, multicopy plasmids from the Vibrio
cholerae seventh pandemic strain (7PET)2. Through a combination of cryo-electron
microscopy, biochemistry and in vivo plasmid clearance assays, we demonstrate
that DdmE is a catalytically inactive, DNA-guided, DNA-targeting pAgo with a distinctive
insertion domain. We observe that the helicase-nuclease DdmD transitions from
an autoinhibited, dimeric complex to a monomeric state upon loading of single-stranded
DNA targets. Furthermore, the complete structure of the DdmDE–guide–target handover
complex provides a comprehensive view into how DNA recognition triggers processive
plasmid destruction. Our work establishes a mechanistic foundation for how pAgos
utilize ancillary factors to achieve plasmid clearance, and provides insights
into anti-plasmid immunity in bacteria.\r\n\r\n"
acknowledgement: We thank K. Kiernan, G. Hibshman and I. Strohkendl for insightful
discussions and comments on the manuscript, and R. Lin for assistance with the ATPase
assay. Data were collected at the Sauer Structural Biology Laboratory at the University
of Texas at Austin. This work was supported in part by the National Institute of
General Medical Sciences (NIGMS) of the National Institutes of Health (NIH) R35GM138348
(to D.W.T.) and Welch Foundation research grant F-1938 (to D.W.T.).
article_processing_charge: No
article_type: original
author:
- first_name: Jack Peter Kelly
full_name: Bravo, Jack Peter Kelly
id: 96aecfa5-8931-11ee-af30-aa6a5d6eee0e
last_name: Bravo
orcid: 0000-0003-0456-0753
- first_name: Delisa A.
full_name: Ramos, Delisa A.
last_name: Ramos
- first_name: Rodrigo
full_name: Fregoso Ocampo, Rodrigo
last_name: Fregoso Ocampo
- first_name: Caiden
full_name: Ingram, Caiden
last_name: Ingram
- first_name: David W.
full_name: Taylor, David W.
last_name: Taylor
citation:
ama: Bravo JPK, Ramos DA, Fregoso Ocampo R, Ingram C, Taylor DW. Plasmid targeting
and destruction by the DdmDE bacterial defence system. Nature. 2024;630(8018):961-967.
doi:10.1038/s41586-024-07515-9
apa: Bravo, J. P. K., Ramos, D. A., Fregoso Ocampo, R., Ingram, C., & Taylor,
D. W. (2024). Plasmid targeting and destruction by the DdmDE bacterial defence
system. Nature. Springer Nature. https://doi.org/10.1038/s41586-024-07515-9
chicago: Bravo, Jack Peter Kelly, Delisa A. Ramos, Rodrigo Fregoso Ocampo, Caiden
Ingram, and David W. Taylor. “Plasmid Targeting and Destruction by the DdmDE Bacterial
Defence System.” Nature. Springer Nature, 2024. https://doi.org/10.1038/s41586-024-07515-9.
ieee: J. P. K. Bravo, D. A. Ramos, R. Fregoso Ocampo, C. Ingram, and D. W. Taylor,
“Plasmid targeting and destruction by the DdmDE bacterial defence system,” Nature,
vol. 630, no. 8018. Springer Nature, pp. 961–967, 2024.
ista: Bravo JPK, Ramos DA, Fregoso Ocampo R, Ingram C, Taylor DW. 2024. Plasmid
targeting and destruction by the DdmDE bacterial defence system. Nature. 630(8018),
961–967.
mla: Bravo, Jack Peter Kelly, et al. “Plasmid Targeting and Destruction by the DdmDE
Bacterial Defence System.” Nature, vol. 630, no. 8018, Springer Nature,
2024, pp. 961–67, doi:10.1038/s41586-024-07515-9.
short: J.P.K. Bravo, D.A. Ramos, R. Fregoso Ocampo, C. Ingram, D.W. Taylor, Nature
630 (2024) 961–967.
corr_author: '1'
date_created: 2024-08-19T09:41:18Z
date_published: 2024-06-27T00:00:00Z
date_updated: 2025-06-24T12:47:21Z
day: '27'
department:
- _id: JaBr
doi: 10.1038/s41586-024-07515-9
external_id:
pmid:
- '38740055'
fulldoi: https://doi.org/10.1038/s41586-024-07515-9
intvolume: ' 630'
issue: '8018'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://pmc.ncbi.nlm.nih.gov/articles/PMC11649018/
month: '06'
oa: 1
oa_version: Submitted Version
page: 961-967
pmid: 1
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Plasmid targeting and destruction by the DdmDE bacterial defence system
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 630
year: '2024'
...
---
_id: '17284'
abstract:
- lang: eng
text: Platelet homeostasis is essential for vascular integrity and immune defence1,2.
Although the process of platelet formation by fragmenting megakaryocytes (MKs;
thrombopoiesis) has been extensively studied, the cellular and molecular mechanisms
required to constantly replenish the pool of MKs by their progenitor cells (megakaryopoiesis)
remains unclear3,4. Here we use intravital imaging to track the cellular dynamics
of megakaryopoiesis over days. We identify plasmacytoid dendritic cells (pDCs)
as homeostatic sensors that monitor the bone marrow for apoptotic MKs and deliver
IFNα to the MK niche triggering local on-demand proliferation and maturation of
MK progenitors. This pDC-dependent feedback loop is crucial for MK and platelet
homeostasis at steady state and under stress. pDCs are best known for their ability
to function as vigilant detectors of viral infection5. We show that virus-induced
activation of pDCs interferes with their function as homeostatic sensors of megakaryopoiesis.
Consequently, activation of pDCs by SARS-CoV-2 leads to excessive megakaryopoiesis.
Together, we identify a pDC-dependent homeostatic circuit that involves innate
immune sensing and demand-adapted release of inflammatory mediators to maintain
homeostasis of the megakaryocytic lineage.
acknowledgement: 'We thank S. Helmer, N. Blount, E. Raatz and Z. Sisic for technical
assistance. This work was funded by the Deutsche Forschungsgemeinschaft (DFG, German
Research Foundation) SFB 1123 (S.M. project B06); SFB 914 (S.M. projects B02 and
Z01, H.I.-A. project Z01, S.S. project A06, K.S. project B02, C. Schulz project
A10, B.W. project A02, C. Scheiermann project B09); SFB 1054 (T.B. project B03);
FOR2033 (F.G., R.A.J.O., S.M.); Individual research grant project ID: 514478744
(F.G.); Heisenberg Programme project ID: 514477451 (F.G.); the DZHK (German Center
for Cardiovascular Research) (MHA 1.4VD (S.M.), Postdoc Start-up Grant, 81×3600213
(F.G.)); and LMUexcellence NFF (F.G.). W.F. received funding from China Scholarship
Council (CSC, no. 201306270012). P.B. is supported by the German Research Foundation
(DFG, project IDs 322900939, 432698239 and 445703531), European Research Council
(ERC Consolidator grant no. 101001791) and the Federal Ministry of Education and
Research (BMBF, STOP-FSGS-01GM2202C and NATON within the framework of the Network
of University Medicine, no. 01KX2121). S.v.S. is supported by the START-Program
of the Faculty of Medicine of the RWTH Aachen University (AZ 125/17). A.D. and S.E.
are supported by the German Research Foundation (SFB TRR 267); S.E. by the BMBF
in the framework of the Cluster4future program (CNATM—Cluster for Nucleic Acid Therapeutics
Munich). This project has received funding from the European Research Council (ERC)
under the European Union’s Horizon 2020 research and innovation programme (grant
agreement no. 833440 to S.M.). F.G. received funding from the European Union’s Horizon
2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement
no. 747687. The project is funded by the European Union (ERC, MEKanics, 101078110).
Views and opinions expressed are those of the author(s) only and do not necessarily
reflect those of the European Union or the European Research Council Executive Agency.
Neither the European Union nor the granting authority can be held responsible for
them.'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Florian R
full_name: Gärtner, Florian R
id: 397A88EE-F248-11E8-B48F-1D18A9856A87
last_name: Gärtner
orcid: 0000-0001-6120-3723
- first_name: Hellen
full_name: Ishikawa-Ankerhold, Hellen
last_name: Ishikawa-Ankerhold
- first_name: Susanne
full_name: Stutte, Susanne
last_name: Stutte
- first_name: Wenwen
full_name: Fu, Wenwen
last_name: Fu
- first_name: Jutta
full_name: Weitz, Jutta
last_name: Weitz
- first_name: Anne
full_name: Dueck, Anne
last_name: Dueck
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full_name: Von Baumgarten, Louisa
last_name: Von Baumgarten
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last_name: Straub
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full_name: Zheden, Vanessa
id: 39C5A68A-F248-11E8-B48F-1D18A9856A87
last_name: Zheden
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full_name: Piontek, Guido
last_name: Piontek
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full_name: Von Stillfried, Saskia
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last_name: Boor
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full_name: Colonna, Marco
last_name: Colonna
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full_name: Clauß, Sebastian
last_name: Clauß
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full_name: Schulz, Christian
last_name: Schulz
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full_name: Brocker, Thomas
last_name: Brocker
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full_name: Walzog, Barbara
last_name: Walzog
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full_name: Scheiermann, Christoph
last_name: Scheiermann
- first_name: William C.
full_name: Aird, William C.
last_name: Aird
- first_name: Claus
full_name: Nerlov, Claus
last_name: Nerlov
- first_name: Konstantin
full_name: Stark, Konstantin
last_name: Stark
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full_name: Petzold, Tobias
last_name: Petzold
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full_name: Engelhardt, Stefan
last_name: Engelhardt
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
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full_name: Hauschild, Robert
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last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Martina
full_name: Rudelius, Martina
last_name: Rudelius
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full_name: Oostendorp, Robert A.J.
last_name: Oostendorp
- first_name: Matteo
full_name: Iannacone, Matteo
last_name: Iannacone
- first_name: Matthias
full_name: Heinig, Matthias
last_name: Heinig
- first_name: Steffen
full_name: Massberg, Steffen
last_name: Massberg
citation:
ama: Gärtner FR, Ishikawa-Ankerhold H, Stutte S, et al. Plasmacytoid dendritic cells
control homeostasis of megakaryopoiesis. Nature. 2024;631:645-653. doi:10.1038/s41586-024-07671-y
apa: Gärtner, F. R., Ishikawa-Ankerhold, H., Stutte, S., Fu, W., Weitz, J., Dueck,
A., … Massberg, S. (2024). Plasmacytoid dendritic cells control homeostasis of
megakaryopoiesis. Nature. Springer Nature. https://doi.org/10.1038/s41586-024-07671-y
chicago: Gärtner, Florian R, Hellen Ishikawa-Ankerhold, Susanne Stutte, Wenwen Fu,
Jutta Weitz, Anne Dueck, Bhavishya Nelakuditi, et al. “Plasmacytoid Dendritic
Cells Control Homeostasis of Megakaryopoiesis.” Nature. Springer Nature,
2024. https://doi.org/10.1038/s41586-024-07671-y.
ieee: F. R. Gärtner et al., “Plasmacytoid dendritic cells control homeostasis
of megakaryopoiesis,” Nature, vol. 631. Springer Nature, pp. 645–653, 2024.
ista: Gärtner FR, Ishikawa-Ankerhold H, Stutte S, Fu W, Weitz J, Dueck A, Nelakuditi
B, Fumagalli V, Van Den Heuvel D, Belz L, Sobirova G, Zhang Z, Titova A, Navarro
AM, Pekayvaz K, Lorenz M, Von Baumgarten L, Kranich J, Straub T, Popper B, Zheden
V, Kaufmann W, Guo C, Piontek G, Von Stillfried S, Boor P, Colonna M, Clauß S,
Schulz C, Brocker T, Walzog B, Scheiermann C, Aird WC, Nerlov C, Stark K, Petzold
T, Engelhardt S, Sixt MK, Hauschild R, Rudelius M, Oostendorp RAJ, Iannacone M,
Heinig M, Massberg S. 2024. Plasmacytoid dendritic cells control homeostasis of
megakaryopoiesis. Nature. 631, 645–653.
mla: Gärtner, Florian R., et al. “Plasmacytoid Dendritic Cells Control Homeostasis
of Megakaryopoiesis.” Nature, vol. 631, Springer Nature, 2024, pp. 645–53,
doi:10.1038/s41586-024-07671-y.
short: F.R. Gärtner, H. Ishikawa-Ankerhold, S. Stutte, W. Fu, J. Weitz, A. Dueck,
B. Nelakuditi, V. Fumagalli, D. Van Den Heuvel, L. Belz, G. Sobirova, Z. Zhang,
A. Titova, A.M. Navarro, K. Pekayvaz, M. Lorenz, L. Von Baumgarten, J. Kranich,
T. Straub, B. Popper, V. Zheden, W. Kaufmann, C. Guo, G. Piontek, S. Von Stillfried,
P. Boor, M. Colonna, S. Clauß, C. Schulz, T. Brocker, B. Walzog, C. Scheiermann,
W.C. Aird, C. Nerlov, K. Stark, T. Petzold, S. Engelhardt, M.K. Sixt, R. Hauschild,
M. Rudelius, R.A.J. Oostendorp, M. Iannacone, M. Heinig, S. Massberg, Nature 631
(2024) 645–653.
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: Imaging and flow cytometry raw data are available on request.
scRNA-seq data are accessible at the GEO (GSE261996). Bulk RNA-seq data are accessible
at the GEO (GSE185488). Source data are provided with this paper.
date_created: 2024-07-21T22:01:02Z
date_published: 2024-07-18T00:00:00Z
date_updated: 2026-10-01T11:17:11Z
day: '18'
ddc:
- '570'
department:
- _id: EM-Fac
- _id: MiSi
- _id: Bio
doi: 10.1038/s41586-024-07671-y
ec_funded: 1
external_id:
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call_identifier: H2020
grant_number: '747687'
name: Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells
publication: Nature
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publisher: Springer Nature
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related_material:
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url: https://github.com/heiniglab/gaertner_megakaryocytes
researchdata_availability: upon request
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status: public
supplementarymaterial: yes
title: Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
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...