[{"file_date_updated":"2025-01-09T09:31:05Z","date_created":"2024-05-12T22:01:02Z","publication":"BioEssays","_id":"15379","day":"01","article_type":"review","quality_controlled":"1","oa":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","title":"Tuning synaptic strength by regulation of AMPA glutamate receptor localization","intvolume":"        46","doi":"10.1002/bies.202400006","article_number":" 2400006","isi":1,"article_processing_charge":"Yes (in subscription journal)","ddc":["570"],"month":"07","citation":{"ieee":"I. Stockwell, J. Watson, and I. H. Greger, “Tuning synaptic strength by regulation of AMPA glutamate receptor localization,” <i>BioEssays</i>, vol. 46, no. 7. Wiley, 2024.","mla":"Stockwell, Imogen, et al. “Tuning Synaptic Strength by Regulation of AMPA Glutamate Receptor Localization.” <i>BioEssays</i>, vol. 46, no. 7, 2400006, Wiley, 2024, doi:<a href=\"https://doi.org/10.1002/bies.202400006\">10.1002/bies.202400006</a>.","apa":"Stockwell, I., Watson, J., &#38; Greger, I. H. (2024). Tuning synaptic strength by regulation of AMPA glutamate receptor localization. <i>BioEssays</i>. Wiley. <a href=\"https://doi.org/10.1002/bies.202400006\">https://doi.org/10.1002/bies.202400006</a>","chicago":"Stockwell, Imogen, Jake Watson, and Ingo H. Greger. “Tuning Synaptic Strength by Regulation of AMPA Glutamate Receptor Localization.” <i>BioEssays</i>. Wiley, 2024. <a href=\"https://doi.org/10.1002/bies.202400006\">https://doi.org/10.1002/bies.202400006</a>.","short":"I. Stockwell, J. Watson, I.H. Greger, BioEssays 46 (2024).","ista":"Stockwell I, Watson J, Greger IH. 2024. Tuning synaptic strength by regulation of AMPA glutamate receptor localization. BioEssays. 46(7), 2400006.","ama":"Stockwell I, Watson J, Greger IH. Tuning synaptic strength by regulation of AMPA glutamate receptor localization. <i>BioEssays</i>. 2024;46(7). doi:<a href=\"https://doi.org/10.1002/bies.202400006\">10.1002/bies.202400006</a>"},"OA_type":"hybrid","status":"public","issue":"7","type":"journal_article","department":[{"_id":"PeJo"}],"license":"https://creativecommons.org/licenses/by/4.0/","abstract":[{"lang":"eng","text":"Long-term potentiation (LTP) of excitatory synapses is a leading model to explain the concept of information storage in the brain. Multiple mechanisms contribute to LTP, but central amongst them is an increased sensitivity of the postsynaptic membrane to neurotransmitter release. This sensitivity is predominantly determined by the abundance and localization of AMPA-type glutamate receptors (AMPARs). A combination of AMPAR structural data, super-resolution imaging of excitatory synapses, and an abundance of electrophysiological studies are providing an ever-clearer picture of how AMPARs are recruited and organized at synaptic junctions. Here, we review the latest insights into this process, and discuss how both cytoplasmic and extracellular receptor elements cooperate to tune the AMPAR response at the hippocampal CA1 synapse."}],"date_published":"2024-07-01T00:00:00Z","language":[{"iso":"eng"}],"acknowledgement":"The authors thank Alexander Scrutton and James M. Krieger for comments on the manuscript. The authors also acknowledge Shraddha Nayak for help with Figure 1B design. This work was supported by grants from the Medical Research Council (MC_U105174197), the BBSRC (BB/N002113/1), and the Wellcome Trust (223194/Z/21/Z) to IHG.","pmid":1,"fulldoi":"https://doi.org/10.1002/bies.202400006","file":[{"success":1,"file_id":"18801","date_updated":"2025-01-09T09:31:05Z","content_type":"application/pdf","file_name":"2024_BioEssays_Stockwell.pdf","date_created":"2025-01-09T09:31:05Z","checksum":"dc8be74156657e8aab12a9d613233ee3","access_level":"open_access","relation":"main_file","file_size":775825,"creator":"dernst"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"external_id":{"pmid":["38693811"],"isi":["001214545700001"]},"OA_place":"publisher","scopus_import":"1","author":[{"first_name":"Imogen","last_name":"Stockwell","full_name":"Stockwell, Imogen"},{"first_name":"Jake","id":"63836096-4690-11EA-BD4E-32803DDC885E","last_name":"Watson","full_name":"Watson, Jake","orcid":"0000-0002-8698-3823"},{"first_name":"Ingo H.","last_name":"Greger","full_name":"Greger, Ingo H."}],"publication_status":"published","year":"2024","volume":46,"date_updated":"2025-09-08T07:25:02Z","has_accepted_license":"1","publisher":"Wiley","oa_version":"Published Version","publication_identifier":{"eissn":["1521-1878"],"issn":["0265-9247"]}},{"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","title":"Gene Drives: Dynamics and regulatory matters – A report from the workshop “Evaluation of spatial and temporal control of Gene Drives”, 4 – 5 April 2019, Vienna","quality_controlled":"1","article_type":"original","day":"01","oa":1,"file_date_updated":"2020-07-14T12:47:42Z","date_created":"2019-09-07T14:40:03Z","_id":"6857","publication":"BioEssays","issue":"11","type":"journal_article","status":"public","citation":{"ista":"Giese B, Friess JL, Schetelig MF, Barton NH, Messer P, Debarre F, Meimberg H, Windbichler N, Boete C. 2019. Gene Drives: Dynamics and regulatory matters – A report from the workshop “Evaluation of spatial and temporal control of Gene Drives”, 4 – 5 April 2019, Vienna. BioEssays. 41(11), 1900151.","ama":"Giese B, Friess JL, Schetelig MF, et al. Gene Drives: Dynamics and regulatory matters – A report from the workshop “Evaluation of spatial and temporal control of Gene Drives”, 4 – 5 April 2019, Vienna. <i>BioEssays</i>. 2019;41(11). doi:<a href=\"https://doi.org/10.1002/bies.201900151\">10.1002/bies.201900151</a>","short":"B. Giese, J.L. Friess, M.F. Schetelig, N.H. Barton, P. Messer, F. Debarre, H. Meimberg, N. Windbichler, C. Boete, BioEssays 41 (2019).","chicago":"Giese, B, J L Friess, M F  Schetelig, Nicholas H Barton, Philip Messer, Florence Debarre, H Meimberg, N Windbichler, and C Boete. “Gene Drives: Dynamics and Regulatory Matters – A Report from the Workshop ‘Evaluation of Spatial and Temporal Control of Gene Drives’, 4 – 5 April 2019, Vienna.” <i>BioEssays</i>. Wiley, 2019. <a href=\"https://doi.org/10.1002/bies.201900151\">https://doi.org/10.1002/bies.201900151</a>.","apa":"Giese, B., Friess, J. L., Schetelig, M. F., Barton, N. H., Messer, P., Debarre, F., … Boete, C. (2019). Gene Drives: Dynamics and regulatory matters – A report from the workshop “Evaluation of spatial and temporal control of Gene Drives”, 4 – 5 April 2019, Vienna. <i>BioEssays</i>. Wiley. <a href=\"https://doi.org/10.1002/bies.201900151\">https://doi.org/10.1002/bies.201900151</a>","ieee":"B. Giese <i>et al.</i>, “Gene Drives: Dynamics and regulatory matters – A report from the workshop ‘Evaluation of spatial and temporal control of Gene Drives’, 4 – 5 April 2019, Vienna,” <i>BioEssays</i>, vol. 41, no. 11. Wiley, 2019.","mla":"Giese, B., et al. “Gene Drives: Dynamics and Regulatory Matters – A Report from the Workshop ‘Evaluation of Spatial and Temporal Control of Gene Drives’, 4 – 5 April 2019, Vienna.” <i>BioEssays</i>, vol. 41, no. 11, 1900151, Wiley, 2019, doi:<a href=\"https://doi.org/10.1002/bies.201900151\">10.1002/bies.201900151</a>."},"month":"11","isi":1,"article_processing_charge":"No","ddc":["570"],"article_number":"1900151","doi":"10.1002/bies.201900151","intvolume":"        41","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"external_id":{"isi":["000489502000001"]},"file":[{"creator":"dernst","file_size":193248,"file_name":"2019_BioEssays_Giese.pdf","checksum":"8cc7551bff70b2658f8d5630f228ee12","access_level":"open_access","date_created":"2019-10-11T06:59:26Z","relation":"main_file","date_updated":"2020-07-14T12:47:42Z","file_id":"6939","content_type":"application/pdf"}],"language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1002/bies.201900151","department":[{"_id":"NiBa"}],"abstract":[{"text":"Gene Drives are regarded as future tools with a high potential for population control. Due to their inherent ability to overcome the rules of Mendelian inheritance, gene drives (GD) may spread genes rapidly through populations of sexually reproducing organisms. A release of organisms carrying a GD would constitute a paradigm shift in the handling of genetically modified organisms because gene drive organisms (GDO) are designed to drive their transgenes into wild populations and thereby increase the number of GDOs. The rapid development in this field and its focus on wild populations demand a prospective risk assessment with a focus on exposure related aspects. Presently, it is unclear how adequate risk management could be guaranteed to limit the spread of GDs in time and space, in order to avoid potential adverse effects in socio‐ecological systems.\r\n\r\nThe recent workshop on the “Evaluation of Spatial and Temporal Control of Gene Drives” hosted by the Institute of Safety/Security and Risk Sciences (ISR) in Vienna aimed at gaining some insight into the potential population dynamic behavior of GDs and appropriate measures of control. Scientists from France, Germany, England, and the USA discussed both topics in this meeting on April 4–5, 2019. This article summarizes results of the workshop.","lang":"eng"}],"date_published":"2019-11-01T00:00:00Z","publication_identifier":{"eissn":["1521-1878"]},"oa_version":"Published Version","year":"2019","volume":41,"date_updated":"2023-08-30T06:56:26Z","has_accepted_license":"1","publisher":"Wiley","scopus_import":"1","author":[{"first_name":"B","last_name":"Giese","full_name":"Giese, B"},{"first_name":"J L","full_name":"Friess, J L","last_name":"Friess"},{"full_name":"Schetelig, M F ","last_name":"Schetelig","first_name":"M F "},{"last_name":"Barton","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Messer, Philip","last_name":"Messer","first_name":"Philip"},{"first_name":"Florence","last_name":"Debarre","full_name":"Debarre, Florence"},{"last_name":"Meimberg","full_name":"Meimberg, H","first_name":"H"},{"first_name":"N","full_name":"Windbichler, N","last_name":"Windbichler"},{"full_name":"Boete, C","last_name":"Boete","first_name":"C"}],"publication_status":"published"}]