@article{21848,
  abstract     = {Despite the success of mRNA therapeutics, challenges remain in optimizing immune responses and minimizing side effects. Cell-specific antigen delivery may help reduce required doses and improve vaccine efficacy. In this study, we report on a targeted delivery system for mRNA to a specific subset of skin-resident antigen-presenting cells: Langerhans cells. By functionalizing lipid nanoparticles with a langerin-specific glycomimetic ligand, we achieve selective mRNA delivery to both murine and human primary Langerhans cells with minimal off-target uptake, at the same time resulting in significantly increased mRNA translation. This targeted mRNA delivery not only enhances antigen presentation and T-cell responses but also enables dose-sparing and superior antitumor immunity compared with conventional immunization in a B16-OVA tumor model. Importantly, our platform’s high compatibility with various lipid nanoparticle formulations offers a flexible and precise tool for skin-directed mRNA delivery.},
  author       = {Klein, Klara and Johnson, Litty and Rîca, Ramona and Sarcevic, Mirza and Carta, Gabriele and Seiser, Saskia and Elbe-Bürger, Adelheid and Langer, Freyja and Rahhal, Nowras and Rademacher, Christoph and Wawrzinek, Robert and Quattrone, Federica and Sparber, Florian},
  issn         = {1523-1747},
  journal      = {Journal of Investigative Dermatology},
  publisher    = {Elsevier},
  title        = {{Langerhans cell–targeted mRNA delivery: A strategy for dose-sparing and enhanced antitumor immunity}},
  doi          = {10.1016/j.jid.2026.03.026},
  year         = {2026},
}

@article{19507,
  abstract     = {The epidermis provides a protective barrier against hostile environments. However, our knowledge of how this barrier forms during development and is subsequently maintained remains incomplete. The infundibulum is a cylindrical epidermal tissue compartment that serves as an outlet for hair follicles protruding from the skin and the excretion of the sebaceous glands that are essential for proper skin function. In this study, we applied quantitative fate mapping to address how infundibulum are maintained during adulthood. We demonstrate that progenitors build and maintain tissues through stochastic cell fate choices. Long-term analysis identified a preferential transient contribution from cells initially located at the bottom of the structure to the maintenance of the tissue, with bursts of local progenitor expansion associated with the phases of hair growth. Beyond providing compartment-wide insights into progenitor cell dynamics in infundibulum, these findings demonstrate how spatiotemporal regulation controls transient progenitor dominance.},
  author       = {Andersen, Marianne S. and Ulyanchenko, Svetlana and Schweiger, Pawel J. and Hannezo, Edouard B and Simons, Benjamin D. and Jensen, Kim B.},
  issn         = {1523-1747},
  journal      = {Journal of Investigative Dermatology},
  number       = {9},
  pages        = {2191--2202.e5},
  publisher    = {Elsevier},
  title        = {{Spatiotemporal switches in progenitor cell fate govern upper hair follicle growth and maintenance}},
  doi          = {10.1016/j.jid.2025.01.034},
  volume       = {145},
  year         = {2025},
}