---
OA_type: closed access
_id: '2623'
abstract:
- lang: eng
  text: Patients with Hodgkin's disease can develop paraneoplastic cerebellar ataxia
    because of the generation of autoantibodies against mGluR1 (mGluR1-Abs). Yet,
    the pathophysiological mechanisms underlying their motor coordination deficits
    remain to be elucidated. Here, we show that application of IgG purified from the
    patients' serum to cerebellar slices of mice acutely reduces the basal activity
    of Purkinje cells, whereas application to the flocculus of mice in vivo evokes
    acute disturbances in the performance of their compensatory eye movements. In
    addition, the mGluR1-Abs block induction of long-term depression in cultured mouse
    Purkinje cells, whereas the cerebellar motor learning behavior of the patients
    is affected in that they show impaired adaptation of their saccadic eye movements.
    Finally, postmortem analysis of the cerebellum of a paraneoplastic cerebellar
    ataxia patient showed that the number of Purkinje cells was significantly reduced
    by approximately two thirds compared with three controls. We conclude that autoantibodies
    against mGluR1 can cause cerebellar motor coordination deficits caused by a combination
    of rapid effects on both acute and plastic responses of Purkinje cells and chronic
    degenerative effects.
article_processing_charge: No
article_type: original
author:
- first_name: Michiel
  full_name: Coesmans, Michiel
  last_name: Coesmans
- first_name: Peter
  full_name: Sillevis Smitt, Peter
  last_name: Sillevis Smitt
- first_name: David
  full_name: Linden, David
  last_name: Linden
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Tomoo
  full_name: Hirano, Tomoo
  last_name: Hirano
- first_name: Yoshinori
  full_name: Yamakawa, Yoshinori
  last_name: Yamakawa
- first_name: Adriaan
  full_name: Van Alphen, Adriaan
  last_name: Van Alphen
- first_name: Chongde
  full_name: Luo, Chongde
  last_name: Luo
- first_name: Jos
  full_name: Van Der Geest, Jos
  last_name: Van Der Geest
- first_name: Johan
  full_name: Kros, Johan
  last_name: Kros
- first_name: Carlo
  full_name: Gaillard, Carlo
  last_name: Gaillard
- first_name: Maarten
  full_name: Frens, Maarten
  last_name: Frens
- first_name: Chris
  full_name: De Zeeuw, Chris
  last_name: De Zeeuw
citation:
  ama: Coesmans M, Sillevis Smitt P, Linden D, et al. Mechanisms underlying cerebellar
    motor deficits due to mGluR1-autoantibodies. <i>Annals of Neurology</i>. 2003;53(3):325-336.
    doi:<a href="https://doi.org/10.1002/ana.10451">10.1002/ana.10451</a>
  apa: Coesmans, M., Sillevis Smitt, P., Linden, D., Shigemoto, R., Hirano, T., Yamakawa,
    Y., … De Zeeuw, C. (2003). Mechanisms underlying cerebellar motor deficits due
    to mGluR1-autoantibodies. <i>Annals of Neurology</i>. Wiley. <a href="https://doi.org/10.1002/ana.10451">https://doi.org/10.1002/ana.10451</a>
  chicago: Coesmans, Michiel, Peter Sillevis Smitt, David Linden, Ryuichi Shigemoto,
    Tomoo Hirano, Yoshinori Yamakawa, Adriaan Van Alphen, et al. “Mechanisms Underlying
    Cerebellar Motor Deficits Due to MGluR1-Autoantibodies.” <i>Annals of Neurology</i>.
    Wiley, 2003. <a href="https://doi.org/10.1002/ana.10451">https://doi.org/10.1002/ana.10451</a>.
  ieee: M. Coesmans <i>et al.</i>, “Mechanisms underlying cerebellar motor deficits
    due to mGluR1-autoantibodies,” <i>Annals of Neurology</i>, vol. 53, no. 3. Wiley,
    pp. 325–336, 2003.
  ista: Coesmans M, Sillevis Smitt P, Linden D, Shigemoto R, Hirano T, Yamakawa Y,
    Van Alphen A, Luo C, Van Der Geest J, Kros J, Gaillard C, Frens M, De Zeeuw C.
    2003. Mechanisms underlying cerebellar motor deficits due to mGluR1-autoantibodies.
    Annals of Neurology. 53(3), 325–336.
  mla: Coesmans, Michiel, et al. “Mechanisms Underlying Cerebellar Motor Deficits
    Due to MGluR1-Autoantibodies.” <i>Annals of Neurology</i>, vol. 53, no. 3, Wiley,
    2003, pp. 325–36, doi:<a href="https://doi.org/10.1002/ana.10451">10.1002/ana.10451</a>.
  short: M. Coesmans, P. Sillevis Smitt, D. Linden, R. Shigemoto, T. Hirano, Y. Yamakawa,
    A. Van Alphen, C. Luo, J. Van Der Geest, J. Kros, C. Gaillard, M. Frens, C. De
    Zeeuw, Annals of Neurology 53 (2003) 325–336.
date_created: 2018-12-11T11:58:44Z
date_published: 2003-03-01T00:00:00Z
date_updated: 2026-05-27T06:49:29Z
day: '01'
doi: 10.1002/ana.10451
extern: '1'
external_id:
  pmid:
  - '12601700'
intvolume: '        53'
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
page: 325 - 336
pmid: 1
publication: Annals of Neurology
publication_identifier:
  eissn:
  - 1531-8249
publication_status: published
publisher: Wiley
publist_id: '4274'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanisms underlying cerebellar motor deficits due to mGluR1-autoantibodies
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 53
year: '2003'
...