[{"project":[{"_id":"349d1832-11ca-11ed-8bc3-d79b574010e0","name":"Reducing the impact of major environmental challenges on mental health","grant_number":"101057429"}],"year":"2025","language":[{"iso":"eng"}],"publisher":"Annual Reviews","PlanS_conform":"1","type":"journal_article","volume":59,"page":"415-434","abstract":[{"text":"The adult human brain, under resting conditions, consumes approximately 20% of total body glucose, a demand that is even higher during the first decade of life. The brain metabolic landscape is intricately regulated throughout development, and each cell type exhibits distinct metabolic signatures at each specific stage. This picture becomes even more intricate when considering that metabolism is dynamically modulated to sustain critical biological processes, such as cell proliferation and differentiation and synaptic activity–dependent processes. The orchestration between metabolic regulation and the aforementioned physiological processes often relies on metabolism-dependent changes in the epigenetic landscape, which shape gene expression patterns to trigger selected downstream biological responses. Perturbations of brain metabolic pathways are frequently the cause of severe neurodevelopmental disorders. This review explores the latest insights into the regulation of brain metabolism in health and disease.","lang":"eng"}],"file":[{"file_size":3629986,"date_created":"2025-12-09T12:53:09Z","success":1,"relation":"main_file","date_updated":"2025-12-09T12:53:09Z","file_name":"2025_AnnualRevGenetics_Marano.pdf","access_level":"open_access","creator":"dernst","file_id":"20745","checksum":"1000228dc9aca3d48e92605607a99c41","content_type":"application/pdf"}],"intvolume":"        59","OA_type":"hybrid","date_updated":"2025-12-09T12:55:11Z","title":"Fueling the mind: Brain metabolism in health and neurodevelopmental disorders","_id":"20731","department":[{"_id":"GaNo"}],"date_created":"2025-12-07T23:02:01Z","publication_identifier":{"issn":["0066-4197"],"eissn":["1545-2948"]},"publication_status":"published","OA_place":"publisher","oa_version":"Published Version","pmid":1,"fulldoi":"https://doi.org/10.1146/annurev-genet-111523-102424","oa":1,"article_processing_charge":"Yes (in subscription journal)","external_id":{"pmid":["40902207"]},"corr_author":"1","acknowledgement":"Funding provided by the European Union (grant 101057429) to G.N.","has_accepted_license":"1","file_date_updated":"2025-12-09T12:53:09Z","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_published":"2025-11-03T00:00:00Z","citation":{"ieee":"D. Marano, V. Mariano, and G. Novarino, “Fueling the mind: Brain metabolism in health and neurodevelopmental disorders,” <i>Annual Review of Genetics</i>, vol. 59. Annual Reviews, pp. 415–434, 2025.","ama":"Marano D, Mariano V, Novarino G. Fueling the mind: Brain metabolism in health and neurodevelopmental disorders. <i>Annual Review of Genetics</i>. 2025;59:415-434. doi:<a href=\"https://doi.org/10.1146/annurev-genet-111523-102424\">10.1146/annurev-genet-111523-102424</a>","chicago":"Marano, Domenico, Vittoria Mariano, and Gaia Novarino. “Fueling the Mind: Brain Metabolism in Health and Neurodevelopmental Disorders.” <i>Annual Review of Genetics</i>. Annual Reviews, 2025. <a href=\"https://doi.org/10.1146/annurev-genet-111523-102424\">https://doi.org/10.1146/annurev-genet-111523-102424</a>.","ista":"Marano D, Mariano V, Novarino G. 2025. Fueling the mind: Brain metabolism in health and neurodevelopmental disorders. Annual Review of Genetics. 59, 415–434.","apa":"Marano, D., Mariano, V., &#38; Novarino, G. (2025). Fueling the mind: Brain metabolism in health and neurodevelopmental disorders. <i>Annual Review of Genetics</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev-genet-111523-102424\">https://doi.org/10.1146/annurev-genet-111523-102424</a>","short":"D. Marano, V. Mariano, G. Novarino, Annual Review of Genetics 59 (2025) 415–434.","mla":"Marano, Domenico, et al. “Fueling the Mind: Brain Metabolism in Health and Neurodevelopmental Disorders.” <i>Annual Review of Genetics</i>, vol. 59, Annual Reviews, 2025, pp. 415–34, doi:<a href=\"https://doi.org/10.1146/annurev-genet-111523-102424\">10.1146/annurev-genet-111523-102424</a>."},"scopus_import":"1","quality_controlled":"1","publication":"Annual Review of Genetics","status":"public","month":"11","ddc":["570"],"author":[{"full_name":"Marano, Domenico","id":"3b004c42-803f-11ed-ab7e-ecee8f08bd58","first_name":"Domenico","last_name":"Marano"},{"last_name":"Mariano","first_name":"Vittoria","full_name":"Mariano, Vittoria","id":"ee829c33-edb3-11ed-b4fb-c020aaca4b01"},{"first_name":"Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","full_name":"Novarino, Gaia","orcid":"0000-0002-7673-7178","last_name":"Novarino"}],"day":"03","article_type":"review","doi":"10.1146/annurev-genet-111523-102424","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"abstract":[{"text":"Multicellular organisms develop complex shapes from much simpler, single-celled zygotes through a process commonly called morphogenesis. Morphogenesis involves an interplay between several factors, ranging from the gene regulatory networks determining cell fate and differentiation to the mechanical processes underlying cell and tissue shape changes. Thus, the study of morphogenesis has historically been based on multidisciplinary approaches at the interface of biology with physics and mathematics. Recent technological advances have further improved our ability to study morphogenesis by bridging the gap between the genetic and biophysical factors through the development of new tools for visualizing, analyzing, and perturbing these factors and their biochemical intermediaries. Here, we review how a combination of genetic, microscopic, biophysical, and biochemical approaches has aided our attempts to understand morphogenesis and discuss potential approaches that may be beneficial to such an inquiry in the future.","lang":"eng"}],"page":"209-233","volume":55,"OA_type":"free access","date_updated":"2026-06-18T08:39:48Z","intvolume":"        55","type":"journal_article","publisher":"Annual Reviews","language":[{"iso":"eng"}],"year":"2021","project":[{"grant_number":"754411","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships"}],"fulldoi":"https://doi.org/10.1146/annurev-genet-071819-103748","pmid":1,"oa_version":"Published Version","OA_place":"publisher","publication_status":"published","article_processing_charge":"No","oa":1,"department":[{"_id":"CaHe"}],"_id":"10406","title":"Dissecting organismal morphogenesis by bridging genetics and biophysics","publication_identifier":{"issn":["0066-4197"],"eissn":["1545-2948"]},"date_created":"2021-12-05T23:01:41Z","citation":{"ama":"Mishra N, Heisenberg C-PJ. Dissecting organismal morphogenesis by bridging genetics and biophysics. <i>Annual Review of Genetics</i>. 2021;55:209-233. doi:<a href=\"https://doi.org/10.1146/annurev-genet-071819-103748\">10.1146/annurev-genet-071819-103748</a>","ieee":"N. Mishra and C.-P. J. Heisenberg, “Dissecting organismal morphogenesis by bridging genetics and biophysics,” <i>Annual Review of Genetics</i>, vol. 55. Annual Reviews, pp. 209–233, 2021.","chicago":"Mishra, Nikhil, and Carl-Philipp J Heisenberg. “Dissecting Organismal Morphogenesis by Bridging Genetics and Biophysics.” <i>Annual Review of Genetics</i>. Annual Reviews, 2021. <a href=\"https://doi.org/10.1146/annurev-genet-071819-103748\">https://doi.org/10.1146/annurev-genet-071819-103748</a>.","apa":"Mishra, N., &#38; Heisenberg, C.-P. J. (2021). Dissecting organismal morphogenesis by bridging genetics and biophysics. <i>Annual Review of Genetics</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev-genet-071819-103748\">https://doi.org/10.1146/annurev-genet-071819-103748</a>","short":"N. Mishra, C.-P.J. Heisenberg, Annual Review of Genetics 55 (2021) 209–233.","ista":"Mishra N, Heisenberg C-PJ. 2021. Dissecting organismal morphogenesis by bridging genetics and biophysics. Annual Review of Genetics. 55, 209–233.","mla":"Mishra, Nikhil, and Carl-Philipp J. Heisenberg. “Dissecting Organismal Morphogenesis by Bridging Genetics and Biophysics.” <i>Annual Review of Genetics</i>, vol. 55, Annual Reviews, 2021, pp. 209–33, doi:<a href=\"https://doi.org/10.1146/annurev-genet-071819-103748\">10.1146/annurev-genet-071819-103748</a>."},"ec_funded":1,"scopus_import":"1","corr_author":"1","external_id":{"pmid":["34460295"],"isi":["000747220900010"]},"date_published":"2021-08-30T00:00:00Z","acknowledgement":"The authors would like to thank Feyza Nur Arslan, Suyash Naik, Diana Pinheiro, Alexandra Schauer, and Shayan Shamipour for their comments on the draft. N.M. is supported by an ISTplus postdoctoral fellowship (H2020 Marie-Sklodowska-Curie COFUND Action).","article_type":"original","day":"30","keyword":["morphogenesis","forward genetics","high-resolution microscopy","biophysics","biochemistry","patterning"],"doi":"10.1146/annurev-genet-071819-103748","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"Annual Review of Genetics","quality_controlled":"1","author":[{"last_name":"Mishra","first_name":"Nikhil","id":"C4D70E82-1081-11EA-B3ED-9A4C3DDC885E","orcid":"0000-0002-6425-5788","full_name":"Mishra, Nikhil"},{"last_name":"Heisenberg","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J"}],"ddc":["570"],"status":"public","isi":1,"month":"08","main_file_link":[{"url":"https://doi.org/10.1146/annurev-genet-071819-103748","open_access":"1"}]},{"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","doi":"10.1146/annurev.ge.23.120189.002005","day":"01","article_type":"original","month":"01","status":"public","author":[{"last_name":"Barton","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H"},{"first_name":"Michael","full_name":"Turelli, Michael","last_name":"Turelli"}],"main_file_link":[{"url":"https://www.annualreviews.org/doi/10.1146/annurev.ge.23.120189.002005"}],"publication":"Annual Review of Genetics","quality_controlled":"1","citation":{"short":"N.H. Barton, M. Turelli, Annual Review of Genetics 23 (1989) 337–370.","apa":"Barton, N. H., &#38; Turelli, M. (1989). Evolutionary quantitative genetics: how little do we know? <i>Annual Review of Genetics</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev.ge.23.120189.002005\">https://doi.org/10.1146/annurev.ge.23.120189.002005</a>","ista":"Barton NH, Turelli M. 1989. Evolutionary quantitative genetics: how little do we know? Annual Review of Genetics. 23, 337–370.","mla":"Barton, Nicholas H., and Michael Turelli. “Evolutionary Quantitative Genetics: How Little Do We Know?” <i>Annual Review of Genetics</i>, vol. 23, Annual Reviews, 1989, pp. 337–70, doi:<a href=\"https://doi.org/10.1146/annurev.ge.23.120189.002005\">10.1146/annurev.ge.23.120189.002005</a>.","chicago":"Barton, Nicholas H, and Michael Turelli. “Evolutionary Quantitative Genetics: How Little Do We Know?” <i>Annual Review of Genetics</i>. Annual Reviews, 1989. <a href=\"https://doi.org/10.1146/annurev.ge.23.120189.002005\">https://doi.org/10.1146/annurev.ge.23.120189.002005</a>.","ieee":"N. H. Barton and M. Turelli, “Evolutionary quantitative genetics: how little do we know?,” <i>Annual Review of Genetics</i>, vol. 23. Annual Reviews, pp. 337–370, 1989.","ama":"Barton NH, Turelli M. Evolutionary quantitative genetics: how little do we know? <i>Annual Review of Genetics</i>. 1989;23:337-370. doi:<a href=\"https://doi.org/10.1146/annurev.ge.23.120189.002005\">10.1146/annurev.ge.23.120189.002005</a>"},"date_published":"1989-01-01T00:00:00Z","acknowledgement":"We thank G. E. Bradford, B. Charlesworth, J. A. Coyne, D. Currie, H. Dingle, J. H. Gillespie, A. Gimelfarb, W. G. Hill, A. A. Hoffmann, K. S. Jackson, J. S. Jones, A. Liebowiz, T. Mitchell-aids , T. A. Mousseau, J. Peck, T. Prout, B. Riska, D. A. Roff, H. B. Shaffer, and M. Slatkin for helpful discussions and comments on earlier drafts. Our research is supported\r\nin part by grants from the Science and Engineering Research Council, the National Science Foundation (BSR-8866548), and the Institute of Theoretical Dynamics at University of California, Davis.","article_processing_charge":"No","oa_version":"None","fulldoi":"https://doi.org/10.1146/annurev.ge.23.120189.002005","publication_status":"published","publication_identifier":{"issn":["0066-4197"],"eissn":["1545-2948"]},"date_created":"2018-12-11T12:08:11Z","title":"Evolutionary quantitative genetics: how little do we know?","_id":"4312","date_updated":"2022-02-09T16:01:46Z","intvolume":"        23","extern":"1","volume":23,"page":"337 - 370","publisher":"Annual Reviews","type":"journal_article","year":"1989","language":[{"iso":"eng"}],"publist_id":"1744"}]