---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21776'
abstract:
- lang: eng
  text: Pyridyl motifs equipped with N-substituents can be powerful ligands for catalysis,
    yet their broader adoption is limited by the lack of a practical method to prepare
    these scaffolds. We report a modular, robust, and versatile Buchwald–Hartwig amination
    protocol that enables the rapid synthesis of bipyridine, phenanthroline, terpyridine,
    and pybox ligands bearing dialkylamine, diarylamine, and heteroaromatic N-substituents.
    These conditions streamline ligand library synthesis and will facilitate systematic
    studies in catalysis and related applications.
acknowledged_ssus:
- _id: LifeSc
- _id: MassSpec
- _id: NMR
- _id: M-Shop
acknowledgement: We gratefully acknowledge ISTA for generous financial support. B.P.
  acknowledges the Austrian Science Fund (PAT 1250924) and the ACS GCI Pharmaceutical
  Roundtable for funding; T.P.Y acknowledges the NSF(CHE-2349003) for financial support.
  This research was supported by the Scientific Service Units (SSU) of ISTA through
  resources provided by the Lab Support Facility, Mass Spec Facility, NMR facility,
  and the Miba Machine Shop. We specifically thank Aikaterina Paraskevopoulou for
  HRMS measurements and Jan Pecak for support with ICP-OES experi-ments. NMR facilities
  at UW−Madison were supported by the NSF(CHE-1048642) and a generous gift from Paul
  J. and Margaret M. Bender. Open Access funding provided by Institute of Science
  and Technology Austria/KEMÖ. This study was supported by Austrian Science Fund (PAT
  1250924), ACSGCI Pharmaceutical Roundtable, and National Science Foundation(CHE-2349003)
  and (CHE-1048642).
article_number: e70417
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Adam
  full_name: Petrik, Adam
  id: e273d403-329f-11ee-a353-8c34c056f8ed
  last_name: Petrik
- first_name: Aleksander
  full_name: Bena, Aleksander
  id: 4197c39e-e8ec-11ed-86cb-afed934cd664
  last_name: Bena
- first_name: Haralds
  full_name: Baunis, Haralds
  id: 2eea55ec-e8ec-11ed-86cb-d9c76787acfe
  last_name: Baunis
- first_name: Riley M.
  full_name: Kelch, Riley M.
  last_name: Kelch
- first_name: Tehshik P.
  full_name: Yoon, Tehshik P.
  last_name: Yoon
- first_name: Bartholomäus
  full_name: Pieber, Bartholomäus
  id: 93e5e5b2-0da6-11ed-8a41-af589a024726
  last_name: Pieber
  orcid: 0000-0001-8689-388X
citation:
  ama: Petrik A, Bena A, Baunis H, Kelch RM, Yoon TP, Pieber B. Facile access to N-substituted
    pyridyl ligands. <i>Advanced Synthesis &#38; Catalysis</i>. 2026;368(9). doi:<a
    href="https://doi.org/10.1002/adsc.70417">10.1002/adsc.70417</a>
  apa: Petrik, A., Bena, A., Baunis, H., Kelch, R. M., Yoon, T. P., &#38; Pieber,
    B. (2026). Facile access to N-substituted pyridyl ligands. <i>Advanced Synthesis
    &#38; Catalysis</i>. Wiley. <a href="https://doi.org/10.1002/adsc.70417">https://doi.org/10.1002/adsc.70417</a>
  chicago: Petrik, Adam, Aleksander Bena, Haralds Baunis, Riley M. Kelch, Tehshik
    P. Yoon, and Bartholomäus Pieber. “Facile Access to N-Substituted Pyridyl Ligands.”
    <i>Advanced Synthesis &#38; Catalysis</i>. Wiley, 2026. <a href="https://doi.org/10.1002/adsc.70417">https://doi.org/10.1002/adsc.70417</a>.
  ieee: A. Petrik, A. Bena, H. Baunis, R. M. Kelch, T. P. Yoon, and B. Pieber, “Facile
    access to N-substituted pyridyl ligands,” <i>Advanced Synthesis &#38; Catalysis</i>,
    vol. 368, no. 9. Wiley, 2026.
  ista: Petrik A, Bena A, Baunis H, Kelch RM, Yoon TP, Pieber B. 2026. Facile access
    to N-substituted pyridyl ligands. Advanced Synthesis &#38; Catalysis. 368(9),
    e70417.
  mla: Petrik, Adam, et al. “Facile Access to N-Substituted Pyridyl Ligands.” <i>Advanced
    Synthesis &#38; Catalysis</i>, vol. 368, no. 9, e70417, Wiley, 2026, doi:<a href="https://doi.org/10.1002/adsc.70417">10.1002/adsc.70417</a>.
  short: A. Petrik, A. Bena, H. Baunis, R.M. Kelch, T.P. Yoon, B. Pieber, Advanced
    Synthesis &#38; Catalysis 368 (2026).
corr_author: '1'
date_created: 2026-05-03T22:01:36Z
date_published: 2026-05-05T00:00:00Z
date_updated: 2026-05-07T07:33:33Z
day: '05'
ddc:
- '540'
department:
- _id: BaPi
- _id: GradSch
doi: 10.1002/adsc.70417
file:
- access_level: open_access
  checksum: afe9752977898642c903abdc70b4a283
  content_type: application/pdf
  creator: dernst
  date_created: 2026-05-07T07:29:24Z
  date_updated: 2026-05-07T07:29:24Z
  file_id: '21833'
  file_name: 2026_AdvSynthCatal_Petrik.pdf
  file_size: 437184
  relation: main_file
  success: 1
file_date_updated: 2026-05-07T07:29:24Z
fulldoi: https://doi.org/10.1002/adsc.70417
has_accepted_license: '1'
intvolume: '       368'
issue: '9'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
project:
- _id: 8f1d607d-16d5-11f0-9cad-ab453295ba5e
  grant_number: PAT 1250924
  name: Photoactive ligands for transformative nickel catalysis
publication: Advanced Synthesis & Catalysis
publication_identifier:
  eissn:
  - 1615-4169
  issn:
  - 1615-4150
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Facile access to N-substituted pyridyl ligands
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 368
year: '2026'
...