[{"day":"05","acknowledgement":"We thank N. Petridou (EMBL) for sharing results before publication. N.M. was supported by funding from the European Union’s Horizon 2020 programme under the Marie Skłodowska-Curie COFUND Actions ISTplus grant agreement number 754411. Y.I.L. acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement number 101034413. The research was supported by funding to C.-P.H. from the NOMIS Foundation, Project ID 1.844. We would like to thank past and present members of the Heisenberg and Hannezo groups for discussions, particularly S. Shamipour, V. Doddihal, M. Jovic, N. Hino, F. N. Arslan, R. Kobylinska and C. Camelo for feedback on the draft manuscript. This research was supported by the Scientific Service Units (SSU) of Institute of Science and Technology Austria through resources provided by the Aquatics Facility, Imaging & Optics Facility (IOF), Scientific Computing (SciComp) facility and Lab Support Facility (LSF). Open access funding provided by Institute of Science and Technology (IST Austria).","PlanS_conform":"1","publication":"Nature Physics","volume":22,"oaworkid":1,"intvolume":"        22","oa":1,"language":[{"iso":"eng"}],"corr_author":"1","OA_place":"publisher","acknowledged_ssus":[{"_id":"PreCl"},{"_id":"Bio"},{"_id":"ScienComp"},{"_id":"LifeSc"}],"year":"2026","_id":"21015","page":"139-150","date_created":"2026-01-20T10:12:19Z","file_date_updated":"2026-01-21T08:21:11Z","article_type":"original","author":[{"orcid":"0000-0002-6425-5788","first_name":"Nikhil","last_name":"Mishra","full_name":"Mishra, Nikhil","id":"C4D70E82-1081-11EA-B3ED-9A4C3DDC885E"},{"last_name":"Li","id":"ee7a5ca8-8b71-11ed-b662-b3341c05b7eb","full_name":"Li, Yuting I","first_name":"Yuting I"},{"last_name":"Hannezo","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561","first_name":"Edouard B"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566"}],"quality_controlled":"1","title":"Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo","scopus_import":"1","file":[{"creator":"dernst","relation":"main_file","file_id":"21026","access_level":"open_access","success":1,"checksum":"0ab7ac2fbcb61a364dba57152db64ed7","file_size":7335694,"content_type":"application/pdf","date_created":"2026-01-21T08:21:11Z","file_name":"2026_NaturePhysics_Mishra.pdf","date_updated":"2026-01-21T08:21:11Z"}],"publisher":"Springer Nature","publication_identifier":{"issn":["1745-2473"],"eissn":["1745-2481"],"issnl":[" 1745-2473"]},"date_updated":"2026-04-28T12:55:30Z","fulldoi":"https://doi.org/10.1038/s41567-025-03122-1","publication_status":"published","ec_funded":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","department":[{"_id":"EdHa"},{"_id":"CaHe"}],"has_accepted_license":"1","article_processing_charge":"Yes (via OA deal)","OA_type":"hybrid","doi":"10.1038/s41567-025-03122-1","project":[{"grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"name":"IST-BRIDGE: International postdoctoral program","grant_number":"101034413","call_identifier":"H2020","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c"},{"_id":"917c023a-16d5-11f0-9cad-eb5cafc52090","name":"Cytoplasmic self-organization into cell-like compartments as a common guiding principle in early animal development"}],"status":"public","ddc":["570"],"citation":{"mla":"Mishra, Nikhil, et al. “Geometry-Driven Asymmetric Cell Divisions Pattern Cell Cycles and Zygotic Genome Activation in the Zebrafish Embryo.” <i>Nature Physics</i>, vol. 22, Springer Nature, 2026, pp. 139–50, doi:<a href=\"https://doi.org/10.1038/s41567-025-03122-1\">10.1038/s41567-025-03122-1</a>.","apa":"Mishra, N., Li, Y. I., Hannezo, E. B., &#38; Heisenberg, C.-P. J. (2026). Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-025-03122-1\">https://doi.org/10.1038/s41567-025-03122-1</a>","short":"N. Mishra, Y.I. Li, E.B. Hannezo, C.-P.J. Heisenberg, Nature Physics 22 (2026) 139–150.","ieee":"N. Mishra, Y. I. Li, E. B. Hannezo, and C.-P. J. Heisenberg, “Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo,” <i>Nature Physics</i>, vol. 22. Springer Nature, pp. 139–150, 2026.","ista":"Mishra N, Li YI, Hannezo EB, Heisenberg C-PJ. 2026. Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo. Nature Physics. 22, 139–150.","chicago":"Mishra, Nikhil, Yuting I Li, Edouard B Hannezo, and Carl-Philipp J Heisenberg. “Geometry-Driven Asymmetric Cell Divisions Pattern Cell Cycles and Zygotic Genome Activation in the Zebrafish Embryo.” <i>Nature Physics</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41567-025-03122-1\">https://doi.org/10.1038/s41567-025-03122-1</a>.","ama":"Mishra N, Li YI, Hannezo EB, Heisenberg C-PJ. Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo. <i>Nature Physics</i>. 2026;22:139-150. doi:<a href=\"https://doi.org/10.1038/s41567-025-03122-1\">10.1038/s41567-025-03122-1</a>"},"date_published":"2026-01-05T00:00:00Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"external_id":{"oaworkid":["W7118187193"]},"type":"journal_article","oa_version":"Published Version","abstract":[{"lang":"eng","text":"Early embryo geometry is one of the most invariant species-specific traits, yet its role in ensuring developmental reproducibility and robustness remains underexplored. Here we show that in zebrafish, the geometry of the fertilized egg—specifically its curvature and volume—serves as a critical initial condition triggering a cascade of events that influence development. The embryo geometry guides patterned asymmetric cell divisions in the blastoderm, generating radial gradients of cell volume and nucleocytoplasmic ratio. These gradients generate mitotic phase waves, with the nucleocytoplasmic ratio determining individual cell cycle periods independently of other cells. We demonstrate that reducing cell autonomy reshapes these waves, emphasizing the instructive role of geometry-derived volume patterns in setting the intrinsic period of the cell cycle oscillator. In addition to organizing cell cycles, early embryo geometry spatially patterns zygotic genome activation at the midblastula transition, a key step in establishing embryonic autonomy. Disrupting the embryo shape alters the zygotic genome activation pattern and causes ectopic germ layer specification, underscoring the developmental significance of geometry. Together, our findings reveal a symmetry-breaking function of early embryo geometry in coordinating cell cycle and transcriptional patterning."}],"related_material":{"link":[{"url":"https://ista.ac.at/en/news/geometry-shapes-life/","relation":"research_data","description":"News on ISTA website"}]},"month":"01"},{"type":"journal_article","das_tickbox":"1","oa_version":"Published Version","abstract":[{"text":"Modern experimental methods in programmable self-assembly make it possible to precisely design particle concentrations, shapes and interactions. However, more physical insight is needed before we can take full advantage of this vast design space to assemble nanostructures with complex form and function. Here we show how a substantial part of this design space can be quickly and comprehensively understood by identifying a class of thermodynamic constraints that act on it. These thermodynamic constraints form a high-dimensional convex polyhedron that determines which nanostructures can be assembled at high equilibrium yield and reveals limitations that govern the coexistence of structures. We validate our predictions through detailed, quantitative assembly experiments of nanoscale particles synthesized using DNA origami. Our results uncover physical relationships underpinning many-component programmable self-assembly in equilibrium and form the basis for robust inverse design, applicable to various systems from biological protein complexes to synthetic nanomachines.","lang":"eng"}],"related_material":{"link":[{"description":"News on ISTA website","url":"https://ista.ac.at/en/news/behind-natures-blueprints/","relation":"press_release"}]},"month":"02","dataavailabilitystatement":"Design files and folding conditions of DNA origami used in this work are provided in the repository Nanobase68 and are accessible at https://nanobase.org/structures/247. All the TEM images and associated experimental data are available via Zenodo at https://doi.org/10.5281/zenodo.17314727 (ref. 70).\r\nStructure enumeration was performed using the Roly.jl27,71 (v.0.1.0) package developed by M.C.H. and C.P.G., which is available via GitHub at https://github.com/mxhbl/Roly.jl. Polyhedral computation and linear programming were performed using the freely available Convex.jl72 (v.0.16.4) package, Polyhedra.jl73 (v.0.7.8) package and cddlib63 (v.0.9.4) library. The example code reproducing the calculations done on the three rings and reconfigurable squares is available via GitHub at https://github.com/mxhbl/PolyhedralStructureOfSelfAssembly. An implementation of the lattice Monte Carlo sampler is available via GitHub at https://github.com/mxhbl/LatticeSampler. Fitting of the yield curves was achieved using the freely available Optim.jl74 (v.1.12.0) package.","OA_type":"hybrid","doi":"10.1038/s41567-025-03120-3","project":[{"grant_number":"FTI23-G-011","name":"Dynamically reconfigurable self-assembly with triangular DNA-origami bricks","_id":"8dd93da8-16d5-11f0-9cad-d2c70200d9a5"}],"status":"public","ddc":["570","540"],"citation":{"ama":"Hübl M, Videbæk TE, Hayakawa D, Rogers WB, Goodrich CP. A polyhedral structure controls programmable self-assembly. <i>Nature Physics</i>. 2026;22:294-301. doi:<a href=\"https://doi.org/10.1038/s41567-025-03120-3\">10.1038/s41567-025-03120-3</a>","chicago":"Hübl, Maximilian, Thomas E. Videbæk, Daichi Hayakawa, W. Benjamin Rogers, and Carl Peter Goodrich. “A Polyhedral Structure Controls Programmable Self-Assembly.” <i>Nature Physics</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41567-025-03120-3\">https://doi.org/10.1038/s41567-025-03120-3</a>.","ista":"Hübl M, Videbæk TE, Hayakawa D, Rogers WB, Goodrich CP. 2026. A polyhedral structure controls programmable self-assembly. Nature Physics. 22, 294–301.","ieee":"M. Hübl, T. E. Videbæk, D. Hayakawa, W. B. Rogers, and C. P. Goodrich, “A polyhedral structure controls programmable self-assembly,” <i>Nature Physics</i>, vol. 22. Springer Nature, pp. 294–301, 2026.","short":"M. Hübl, T.E. Videbæk, D. Hayakawa, W.B. Rogers, C.P. Goodrich, Nature Physics 22 (2026) 294–301.","mla":"Hübl, Maximilian, et al. “A Polyhedral Structure Controls Programmable Self-Assembly.” <i>Nature Physics</i>, vol. 22, Springer Nature, 2026, pp. 294–301, doi:<a href=\"https://doi.org/10.1038/s41567-025-03120-3\">10.1038/s41567-025-03120-3</a>.","apa":"Hübl, M., Videbæk, T. E., Hayakawa, D., Rogers, W. B., &#38; Goodrich, C. P. (2026). A polyhedral structure controls programmable self-assembly. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-025-03120-3\">https://doi.org/10.1038/s41567-025-03120-3</a>"},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"date_published":"2026-02-01T00:00:00Z","department":[{"_id":"CaGo"},{"_id":"GradSch"}],"article_processing_charge":"Yes (via OA deal)","has_accepted_license":"1","publication_status":"published","fulldoi":"https://doi.org/10.1038/s41567-025-03120-3","date_updated":"2026-07-27T10:59:15Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","researchdata_availability":"yes","article_type":"original","author":[{"last_name":"Hübl","id":"5eb8629e-15b2-11ec-abd3-e6f3e5e01f32","full_name":"Hübl, Maximilian","first_name":"Maximilian"},{"last_name":"Videbæk","full_name":"Videbæk, Thomas E.","first_name":"Thomas E."},{"first_name":"Daichi","last_name":"Hayakawa","full_name":"Hayakawa, Daichi"},{"full_name":"Rogers, W. Benjamin","last_name":"Rogers","first_name":"W. Benjamin"},{"id":"EB352CD2-F68A-11E9-89C5-A432E6697425","full_name":"Goodrich, Carl Peter","last_name":"Goodrich","first_name":"Carl Peter","orcid":"0000-0002-1307-5074"}],"title":"A polyhedral structure controls programmable self-assembly","quality_controlled":"1","file":[{"checksum":"f4e3123d5d9dfcd22324e2c2de02e9a2","success":1,"access_level":"open_access","file_id":"22417","creator":"dernst","relation":"main_file","file_name":"2026_NaturePhysics_Huebl.pdf","date_created":"2026-07-27T10:57:57Z","date_updated":"2026-07-27T10:57:57Z","content_type":"application/pdf","file_size":2802534}],"scopus_import":"1","publication_identifier":{"issn":["1745-2473"],"eissn":["1745-2481"]},"publisher":"Springer Nature","supplementarymaterial":"yes","file_date_updated":"2026-07-27T10:57:57Z","_id":"21006","page":"294-301","date_created":"2026-01-20T10:02:19Z","intvolume":"        22","oa":1,"OA_place":"publisher","corr_author":"1","language":[{"iso":"eng"}],"year":"2026","acknowledgement":"We thank B. Isaac and A. Tiano for their technical support with the electron microscopy and S. Waitukaitis for helpful comments on the manuscript. The TEM images were prepared and imaged at the Brandeis Electron Microscopy facility. This work was supported by the Gesellschaft für Forschungsförderung Niederösterreich under project FTI23-G-011 (M.C.H. and C.P.G.), the Brandeis University Materials Research Science and Engineering Center (MRSEC) under grant number NSF DMR-2011846 (T.E.V., D.H. and W.B.R.) and the Smith Family Foundation (W.B.R.). Open access funding provided by Institute of Science and Technology (IST Austria).","day":"01","PlanS_conform":"1","publication":"Nature Physics","volume":22},{"department":[{"_id":"GradSch"},{"_id":"BjHo"}],"has_accepted_license":"1","article_processing_charge":"Yes (via OA deal)","date_updated":"2026-07-27T11:13:48Z","fulldoi":"https://doi.org/10.1038/s41567-025-03166-3","publication_status":"published","researchdata_availability":"yes","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"text":"Depending on the type of flow, the transition to turbulence can take one of two forms: either turbulence arises from a sequence of instabilities or from the spatial proliferation of transiently chaotic domains, a process analogous to directed percolation. The former scenario is commonly referred to as a supercritical transition and frequently encountered in flows destabilized by body forces, whereas the latter subcritical transition is common in shear flows. Both cases are inherently continuous in a sense that the transformation from ordered laminar to fully turbulent fluid motion is only accomplished gradually with flow speed. Here we show that these established transition types do not account for the more general setting of shear flows subject to body forces. The combination of the two continuous scenarios leads to the attenuation of spatial coupling; with increasing forcing amplitude, the transition becomes increasingly sharp and eventually discontinuous. We argue that the suppression of laminar–turbulent coexistence and the approach towards a discontinuous phase transition potentially apply to a broad range of situations including flows subject to, for example, buoyancy, centrifugal or electromagnetic forces.","lang":"eng"}],"month":"03","external_id":{"arxiv":["2311.11474"]},"type":"journal_article","oa_version":"Published Version","das_tickbox":"1","citation":{"mla":"Yang, Bowen, et al. “Discontinuous Transition to Shear Flow Turbulence.” <i>Nature Physics</i>, vol. 22, Springer Nature, 2026, pp. 424–29, doi:<a href=\"https://doi.org/10.1038/s41567-025-03166-3\">10.1038/s41567-025-03166-3</a>.","apa":"Yang, B., Zhuang, Y., Yalniz, G., Vasudevan, M., Marensi, E., &#38; Hof, B. (2026). Discontinuous transition to shear flow turbulence. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-025-03166-3\">https://doi.org/10.1038/s41567-025-03166-3</a>","short":"B. Yang, Y. Zhuang, G. Yalniz, M. Vasudevan, E. Marensi, B. Hof, Nature Physics 22 (2026) 424–429.","ieee":"B. Yang, Y. Zhuang, G. Yalniz, M. Vasudevan, E. Marensi, and B. Hof, “Discontinuous transition to shear flow turbulence,” <i>Nature Physics</i>, vol. 22. Springer Nature, pp. 424–429, 2026.","ama":"Yang B, Zhuang Y, Yalniz G, Vasudevan M, Marensi E, Hof B. Discontinuous transition to shear flow turbulence. <i>Nature Physics</i>. 2026;22:424-429. doi:<a href=\"https://doi.org/10.1038/s41567-025-03166-3\">10.1038/s41567-025-03166-3</a>","ista":"Yang B, Zhuang Y, Yalniz G, Vasudevan M, Marensi E, Hof B. 2026. Discontinuous transition to shear flow turbulence. Nature Physics. 22, 424–429.","chicago":"Yang, Bowen, Yi Zhuang, Gökhan Yalniz, Mukund Vasudevan, Elena Marensi, and Björn Hof. “Discontinuous Transition to Shear Flow Turbulence.” <i>Nature Physics</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41567-025-03166-3\">https://doi.org/10.1038/s41567-025-03166-3</a>."},"ddc":["532"],"date_published":"2026-03-01T00:00:00Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"OA_type":"hybrid","dataavailabilitystatement":"Source data are available via Zenodo at https://doi.org/10.5281/zenodo.17514317 (ref. 51). The numerical simulations were carried out using the open-source codes openpipeflow41 and nsPipeflow45.","doi":"10.1038/s41567-025-03166-3","project":[{"_id":"238598C6-32DE-11EA-91FC-C7463DDC885E","name":"Revisiting the Turbulence Problem Using Statistical Mechanics","grant_number":"662960"}],"status":"public","language":[{"iso":"eng"}],"corr_author":"1","OA_place":"publisher","year":"2026","intvolume":"        22","oa":1,"publication":"Nature Physics","volume":22,"arxiv":1,"day":"01","acknowledgement":"The work was supported by the Simons Foundation (grant number 662960, to B.H.). Open access funding provided by Institute of Science and Technology (IST Austria).","PlanS_conform":"1","scopus_import":"1","file":[{"creator":"dernst","relation":"main_file","file_id":"22420","access_level":"open_access","success":1,"checksum":"0636abba74896c467a7237411fa2369b","file_size":5152735,"content_type":"application/pdf","date_updated":"2026-07-27T11:12:46Z","file_name":"2026_NaturePhysics_Yang.pdf","date_created":"2026-07-27T11:12:46Z"}],"publisher":"Springer Nature","publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"author":[{"orcid":"0000-0002-4843-6853","first_name":"Bowen","id":"71b6ff4b-15b2-11ec-abd3-aef6b028cf7e","last_name":"Yang","full_name":"Yang, Bowen"},{"last_name":"Zhuang","id":"3677B57C-F248-11E8-B48F-1D18A9856A87","full_name":"Zhuang, Yi","first_name":"Yi"},{"orcid":"0000-0002-8490-9312","first_name":"Gökhan","full_name":"Yalniz, Gökhan","id":"66E74FA2-D8BF-11E9-8249-8DE2E5697425","last_name":"Yalniz"},{"first_name":"Mukund","full_name":"Vasudevan, Mukund","id":"3C5A959A-F248-11E8-B48F-1D18A9856A87","last_name":"Vasudevan"},{"first_name":"Elena","orcid":"0000-0001-7173-4923","full_name":"Marensi, Elena","last_name":"Marensi","id":"0BE7553A-1004-11EA-B805-18983DDC885E"},{"first_name":"Björn","orcid":"0000-0003-2057-2754","last_name":"Hof","full_name":"Hof, Björn","id":"3A374330-F248-11E8-B48F-1D18A9856A87"}],"article_type":"original","quality_controlled":"1","title":"Discontinuous transition to shear flow turbulence","_id":"21295","page":"424-429","date_created":"2026-02-17T11:38:41Z","file_date_updated":"2026-07-27T11:12:46Z","supplementarymaterial":"yes"},{"has_accepted_license":"1","article_processing_charge":"Yes (via OA deal)","department":[{"_id":"JePa"}],"pmid":1,"researchdata_availability":"yes","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-07-27T12:29:45Z","fulldoi":"https://doi.org/10.1038/s41567-026-03189-4","publication_status":"published","das_tickbox":"1","oa_version":"Published Version","external_id":{"pmid":["42006933"]},"type":"journal_article","month":"04","abstract":[{"lang":"eng","text":"Swimming bacteria move through a fluid by actuating their moving body parts. They are force-free and can be described as hydrodynamic force dipoles: pushers or pullers. This modelling description is broadly used in biological physics and active matter research, and it has successfully predicted, for example, the superfluid behaviour of suspensions of pushers or the bend instability and emergence of turbulent flows in active nematics. However, this description accounts only for the translational motion of the swimming body and neglects the effects of hydrodynamic torque dipoles, which are relevant to bacteria with rotary motor-driven flagella, such as swimming Escherichia coli. Here we show that the torque dipole of confined swimming E. coli can power the persistent rotation of symmetric discs. The torque dipole leads to a traction force on the discs, an additive mechanism that is both contactless and independent of the orientation of the bacteria. Our results indicate that the torque dipole of swimming E. coli is notable in confined geometries, which is relevant to bacterial transport through porous materials, biofilms and the development of chiral fluids."}],"project":[{"_id":"bdac72da-d553-11ed-ba76-eae56e802b74","grant_number":"101086998","name":"VULCAN: matter, powered from within"}],"status":"public","OA_type":"hybrid","doi":"10.1038/s41567-026-03189-4","dataavailabilitystatement":"The datasets generated and analysed during the current study are openly available via Zenodo at https://doi.org/10.5281/zenodo.15236674 (ref. 32). All data are released under the CC-BY 4.0 licence. For any further questions about data access or reuse, please contact the corresponding author.","date_published":"2026-04-01T00:00:00Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"ddc":["570","530"],"citation":{"mla":"Grober, Daniel B., et al. “The Hydrodynamic Torque Dipole from Rotary Bacterial Flagella Powers Symmetric Discs.” <i>Nature Physics</i>, vol. 22, Springer Nature, 2026, pp. 620–27, doi:<a href=\"https://doi.org/10.1038/s41567-026-03189-4\">10.1038/s41567-026-03189-4</a>.","apa":"Grober, D. B., Dhar, T., Saintillan, D., &#38; Palacci, J. A. (2026). The hydrodynamic torque dipole from rotary bacterial flagella powers symmetric discs. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-026-03189-4\">https://doi.org/10.1038/s41567-026-03189-4</a>","short":"D.B. Grober, T. Dhar, D. Saintillan, J.A. Palacci, Nature Physics 22 (2026) 620–627.","ieee":"D. B. Grober, T. Dhar, D. Saintillan, and J. A. Palacci, “The hydrodynamic torque dipole from rotary bacterial flagella powers symmetric discs,” <i>Nature Physics</i>, vol. 22. Springer Nature, pp. 620–627, 2026.","chicago":"Grober, Daniel B, Tanumoy Dhar, David Saintillan, and Jérémie A Palacci. “The Hydrodynamic Torque Dipole from Rotary Bacterial Flagella Powers Symmetric Discs.” <i>Nature Physics</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41567-026-03189-4\">https://doi.org/10.1038/s41567-026-03189-4</a>.","ama":"Grober DB, Dhar T, Saintillan D, Palacci JA. The hydrodynamic torque dipole from rotary bacterial flagella powers symmetric discs. <i>Nature Physics</i>. 2026;22:620-627. doi:<a href=\"https://doi.org/10.1038/s41567-026-03189-4\">10.1038/s41567-026-03189-4</a>","ista":"Grober DB, Dhar T, Saintillan D, Palacci JA. 2026. The hydrodynamic torque dipole from rotary bacterial flagella powers symmetric discs. Nature Physics. 22, 620–627."},"oa":1,"intvolume":"        22","acknowledged_ssus":[{"_id":"NanoFab"},{"_id":"EM-Fac"}],"year":"2026","language":[{"iso":"eng"}],"corr_author":"1","OA_place":"publisher","PlanS_conform":"1","day":"01","acknowledgement":"We thank E. Krasnopeeva for help with the bacterial culture, motility and genetic engineering. We thank Q. Martinet for help with the experimental design, F. Pertl for atomic force microscopy measurements and S. Hajek for the scanning electron microscopy imaging. This project has received funding from the European Research Council under the European Union’s Horizon Europe research and innovation programme (VULCAN, 101086998). The views and opinions expressed are, however, those of the authors only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency. Neither the European Union nor the granting authority can be held responsible for them. J.P. thanks the Nanofabrication and Electron Microscopy Shared Scientific Units of ISTA for support. Open access funding provided by Institute of Science and Technology (IST Austria).","volume":22,"publication":"Nature Physics","quality_controlled":"1","title":"The hydrodynamic torque dipole from rotary bacterial flagella powers symmetric discs","article_type":"original","author":[{"first_name":"Daniel B","last_name":"Grober","id":"c692f879-718d-11ee-81f0-da7caa79c783","full_name":"Grober, Daniel B"},{"full_name":"Dhar, Tanumoy","last_name":"Dhar","first_name":"Tanumoy"},{"first_name":"David","full_name":"Saintillan, David","last_name":"Saintillan"},{"first_name":"Jérémie A","orcid":"0000-0002-7253-9465","full_name":"Palacci, Jérémie A","last_name":"Palacci","id":"8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d"}],"publisher":"Springer Nature","publication_identifier":{"issn":["1745-2473"],"eissn":["1745-2481"]},"scopus_import":"1","file":[{"content_type":"application/pdf","date_updated":"2026-07-27T12:28:27Z","date_created":"2026-07-27T12:28:27Z","file_name":"2026_NaturePhysics_Grober.pdf","file_size":2960392,"file_id":"22429","access_level":"open_access","relation":"main_file","creator":"dernst","success":1,"checksum":"bb28ed456cdd288d97854b084dd4b2e1"}],"supplementarymaterial":"yes","_id":"21721","date_created":"2026-04-12T22:01:51Z","page":"620-627","file_date_updated":"2026-07-27T12:28:27Z"},{"publisher":"Springer Nature","publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"scopus_import":"1","file":[{"file_size":7932222,"content_type":"application/pdf","date_updated":"2026-07-27T13:54:58Z","date_created":"2026-07-27T13:54:58Z","file_name":"2026_NaturePhysics_Olmeda.pdf","success":1,"checksum":"58e7734f1ebaf6def642140cb489f08f","creator":"dernst","relation":"main_file","file_id":"22591","access_level":"open_access"}],"quality_controlled":"1","title":"Scaling and self-similarity in the formation of the embryonic epigenome","article_type":"original","author":[{"last_name":"Olmeda","id":"69dbf5fb-8a76-11ed-866b-fb486d8b5689","full_name":"Olmeda, Fabrizio","first_name":"Fabrizio"},{"first_name":"Tim","full_name":"Lohoff, Tim","last_name":"Lohoff"},{"full_name":"Kafetzopoulos, Ioannis","last_name":"Kafetzopoulos","first_name":"Ioannis"},{"first_name":"Stephen J.","last_name":"Clark","full_name":"Clark, Stephen J."},{"first_name":"Laura","last_name":"Benson","full_name":"Benson, Laura"},{"first_name":"Fatima","last_name":"Santos","full_name":"Santos, Fatima"},{"first_name":"Felix","last_name":"Krueger","full_name":"Krueger, Felix"},{"first_name":"Simon","full_name":"Walker, Simon","last_name":"Walker"},{"first_name":"Wolf","full_name":"Reik, Wolf","last_name":"Reik"},{"first_name":"Steffen","last_name":"Rulands","full_name":"Rulands, Steffen"}],"date_created":"2026-05-10T22:02:16Z","_id":"21849","page":"931-940","file_date_updated":"2026-07-27T13:54:58Z","supplementarymaterial":"yes","year":"2026","language":[{"iso":"eng"}],"OA_place":"publisher","oa":1,"intvolume":"        22","publication":"Nature Physics","volume":22,"PlanS_conform":"1","day":"01","acknowledgement":"We thank all members of the W.R. and S.R. laboratories, F. Piazza, B. D. Simons, and F. Jülicher for helpful discussions. We thank M. Ciarchi for providing annotations for the chromatin compartments. S.R. is a member of the Center for Nano Science (CeNS). This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement number 950349). Research in W.R.’s laboratory was supported by the Biotechnology and Biological Sciences Research Council (BB/K010867/1), Wellcome (095645/Z/11/Z) and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (EpiCell lineage 882798). F.O. received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement number 101034413. Open access funding provided by Max Planck Society.","month":"06","abstract":[{"text":"The development of complex tissues relies on the precise assignment of cell identity. At the molecular scale, this process depends on the deposition of epigenetic modifications—such as methylation—that are regulated by complex biochemical networks and occur at specific regions on the DNA and chromatin. Here we show that despite the complexity of epigenetic regulation, dynamical scaling and self-similarity of DNA methylation marks emerge in embryonic development. Drawing on single-cell multi-omics experiments, super-resolution microscopy and statistical physics, we demonstrate that these phenomena originate in dynamical feedback between DNA methylation and the formation of nanoscale dynamic chromatin aggregates. These nanoscale processes lead to genome-wide increase in DNA methylation marks following a power law and self-similar correlation functions. Using this framework, we identify methylation patterns that precede gene expression changes in embryonic symmetry breaking. Our work identifies linear sequencing measurements as a laboratory to study mesoscopic biophysical processes in vivo.","lang":"eng"}],"das_tickbox":"1","oa_version":"Published Version","type":"journal_article","external_id":{"pmid":["42318073"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"date_published":"2026-06-01T00:00:00Z","citation":{"ieee":"F. Olmeda <i>et al.</i>, “Scaling and self-similarity in the formation of the embryonic epigenome,” <i>Nature Physics</i>, vol. 22. Springer Nature, pp. 931–940, 2026.","short":"F. Olmeda, T. Lohoff, I. Kafetzopoulos, S.J. Clark, L. Benson, F. Santos, F. Krueger, S. Walker, W. Reik, S. Rulands, Nature Physics 22 (2026) 931–940.","ama":"Olmeda F, Lohoff T, Kafetzopoulos I, et al. Scaling and self-similarity in the formation of the embryonic epigenome. <i>Nature Physics</i>. 2026;22:931-940. doi:<a href=\"https://doi.org/10.1038/s41567-026-03263-x\">10.1038/s41567-026-03263-x</a>","ista":"Olmeda F, Lohoff T, Kafetzopoulos I, Clark SJ, Benson L, Santos F, Krueger F, Walker S, Reik W, Rulands S. 2026. Scaling and self-similarity in the formation of the embryonic epigenome. Nature Physics. 22, 931–940.","chicago":"Olmeda, Fabrizio, Tim Lohoff, Ioannis Kafetzopoulos, Stephen J. Clark, Laura Benson, Fatima Santos, Felix Krueger, Simon Walker, Wolf Reik, and Steffen Rulands. “Scaling and Self-Similarity in the Formation of the Embryonic Epigenome.” <i>Nature Physics</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41567-026-03263-x\">https://doi.org/10.1038/s41567-026-03263-x</a>.","apa":"Olmeda, F., Lohoff, T., Kafetzopoulos, I., Clark, S. J., Benson, L., Santos, F., … Rulands, S. (2026). Scaling and self-similarity in the formation of the embryonic epigenome. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-026-03263-x\">https://doi.org/10.1038/s41567-026-03263-x</a>","mla":"Olmeda, Fabrizio, et al. “Scaling and Self-Similarity in the Formation of the Embryonic Epigenome.” <i>Nature Physics</i>, vol. 22, Springer Nature, 2026, pp. 931–40, doi:<a href=\"https://doi.org/10.1038/s41567-026-03263-x\">10.1038/s41567-026-03263-x</a>."},"ddc":["570"],"status":"public","project":[{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020","grant_number":"101034413","name":"IST-BRIDGE: International postdoctoral program"}],"OA_type":"hybrid","dataavailabilitystatement":"All sequencing datasets reported in this paper are available on Gene Expression Omnibus (GEO) under accession GSE166226. STORM localization data are available on Zenodo (https://doi.org/10.5281/zenodo.18965309)57. Raw images are available upon request. Code for computing the correlation functions and STORM analysis are available via GitHub at https://github.com/srulands/inference_of_spatio-temporal_processes.","doi":"10.1038/s41567-026-03263-x","pmid":1,"has_accepted_license":"1","article_processing_charge":"Yes (via OA deal)","department":[{"_id":"EdHa"}],"researchdata_availability":"yes","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ec_funded":1,"fulldoi":"https://doi.org/10.1038/s41567-026-03263-x","date_updated":"2026-07-27T13:56:09Z","publication_status":"published"},{"ec_funded":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","fulldoi":"https://doi.org/10.1038/s41567-024-02765-w","date_updated":"2025-09-30T10:29:15Z","publication_status":"published","has_accepted_license":"1","article_processing_charge":"Yes (via OA deal)","department":[{"_id":"MaSe"}],"pmid":1,"project":[{"call_identifier":"H2020","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","grant_number":"101034413","name":"IST-BRIDGE: International postdoctoral program"}],"status":"public","doi":"10.1038/s41567-024-02765-w","isi":1,"OA_type":"hybrid","date_published":"2025-03-01T00:00:00Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"ddc":["530"],"citation":{"ieee":"J. Vodeb <i>et al.</i>, “Stirring the false vacuum via interacting quantized bubbles on a 5,564-qubit quantum annealer,” <i>Nature Physics</i>, vol. 21. Springer Nature, pp. 386–392, 2025.","short":"J. Vodeb, J.-Y.M. Desaules, A. Hallam, A. Rava, G. Humar, D. Willsch, F. Jin, M. Willsch, K. Michielsen, Z. Papić, Nature Physics 21 (2025) 386–392.","chicago":"Vodeb, Jaka, Jean-Yves Marc Desaules, Andrew Hallam, Andrea Rava, Gregor Humar, Dennis Willsch, Fengping Jin, Madita Willsch, Kristel Michielsen, and Zlatko Papić. “Stirring the False Vacuum via Interacting Quantized Bubbles on a 5,564-Qubit Quantum Annealer.” <i>Nature Physics</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41567-024-02765-w\">https://doi.org/10.1038/s41567-024-02765-w</a>.","ista":"Vodeb J, Desaules J-YM, Hallam A, Rava A, Humar G, Willsch D, Jin F, Willsch M, Michielsen K, Papić Z. 2025. Stirring the false vacuum via interacting quantized bubbles on a 5,564-qubit quantum annealer. Nature Physics. 21, 386–392.","ama":"Vodeb J, Desaules J-YM, Hallam A, et al. Stirring the false vacuum via interacting quantized bubbles on a 5,564-qubit quantum annealer. <i>Nature Physics</i>. 2025;21:386-392. doi:<a href=\"https://doi.org/10.1038/s41567-024-02765-w\">10.1038/s41567-024-02765-w</a>","mla":"Vodeb, Jaka, et al. “Stirring the False Vacuum via Interacting Quantized Bubbles on a 5,564-Qubit Quantum Annealer.” <i>Nature Physics</i>, vol. 21, Springer Nature, 2025, pp. 386–92, doi:<a href=\"https://doi.org/10.1038/s41567-024-02765-w\">10.1038/s41567-024-02765-w</a>.","apa":"Vodeb, J., Desaules, J.-Y. M., Hallam, A., Rava, A., Humar, G., Willsch, D., … Papić, Z. (2025). Stirring the false vacuum via interacting quantized bubbles on a 5,564-qubit quantum annealer. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-024-02765-w\">https://doi.org/10.1038/s41567-024-02765-w</a>"},"oa_version":"Published Version","type":"journal_article","external_id":{"arxiv":["2406.14718"],"isi":["001412684400001"],"pmid":["40093970"]},"month":"03","abstract":[{"lang":"eng","text":"False vacuum decay—the transition from a metastable quantum state to a true vacuum state—plays an important role in quantum field theory and non-equilibrium phenomena such as phase transitions and dynamical metastability. The non-perturbative nature of false vacuum decay and the limited experimental access to this process make it challenging to study, leaving several open questions regarding how true vacuum bubbles form, move and interact. Here we observe quantized bubble formation in real time, a key feature of false vacuum decay dynamics, using a quantum annealer with 5,564 superconducting flux qubits. We develop an effective model that captures both initial bubble creation and subsequent interactions, and remains accurate under dissipation. The annealer reveals coherent scaling laws in the driven many-body dynamics for more than 1,000 intrinsic qubit time units. This work provides a method for investigating false vacuum dynamics of large quantum systems in quantum annealers."}],"related_material":{"link":[{"description":"News on ISTA Website","relation":"press_release","url":"https://ista.ac.at/en/news/dancing-bubbles-model-a-cosmic-disaster/"}]},"PlanS_conform":"1","day":"01","arxiv":1,"acknowledgement":"J.V., D.W. and M.W. acknowledge support from the project Jülich UNified Infrastructure for Quantum computing (JUNIQ) that has received funding from the German Federal Ministry of Education and Research (BMBF) and the Ministry of Culture and Science of the State of North Rhine-Westphalia. A.R. acknowledges support from the project HPCQS (101018180) of the European High-Performance Computing Joint Undertaking (EuroHPC JU). J.-Y.D., A.H. and Z.P. acknowledge support from the Leverhulme Trust Research Leadership Award RL-2019-015 and EPSRC grant nos. EP/R513258/1 and EP/W026848/1. J.-Y.D. acknowledges support from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no.101034413. This research was supported in part by grant no. NSF PHY-2309135 to the Kavli Institute for Theoretical Physics (KITP). Computational portions of this research work were carried out on ARC3 and ARC4, part of the high-performance computing facilities at the University of Leeds. G.H. acknowledges financial support from ARIS, P1-0040 Nonequilibrium Quantum System Dynamics. We gratefully acknowledge the Jülich Supercomputing Centre (https://www.fz-juelich.de/en/ias/jsc) for funding this project by providing computing time on the D-Wave Advantage System JUPSI through JUNIQ. We acknowledge helpful theoretical discussions with G. Lagnese and the quantum-simulation-related discussions with D-Wave’s experimental team, particularly A. MacDonald, G. Poulin-Lamarre, A. Daian and A. Berkley. We also thank V. Goliber and A. Mason for patiently organizing and mediating the corresponding meetings that enabled the discussions with D-Wave’s team. J.V., A.R., D.W., F.J., M.W. and K.M. gratefully acknowledge the Gauss Centre for Supercomputing e.V. (www.gauss-centre.eu) for funding this project by providing computing time on the GCS Supercomputer JUWELS at Jülich Supercomputing Centre (JSC).","volume":21,"publication":"Nature Physics","oa":1,"intvolume":"        21","year":"2025","language":[{"iso":"eng"}],"OA_place":"publisher","corr_author":"1","_id":"19012","date_created":"2025-02-06T10:07:13Z","page":"386-392","file_date_updated":"2025-08-05T11:56:53Z","quality_controlled":"1","title":"Stirring the false vacuum via interacting quantized bubbles on a 5,564-qubit quantum annealer","author":[{"full_name":"Vodeb, Jaka","last_name":"Vodeb","first_name":"Jaka"},{"id":"6c292945-a610-11ed-9eec-c3be1ad62a80","full_name":"Desaules, Jean-Yves Marc","last_name":"Desaules","orcid":"0000-0002-3749-6375","first_name":"Jean-Yves Marc"},{"first_name":"Andrew","full_name":"Hallam, Andrew","last_name":"Hallam"},{"full_name":"Rava, Andrea","last_name":"Rava","first_name":"Andrea"},{"first_name":"Gregor","full_name":"Humar, Gregor","last_name":"Humar"},{"first_name":"Dennis","full_name":"Willsch, Dennis","last_name":"Willsch"},{"last_name":"Jin","full_name":"Jin, Fengping","first_name":"Fengping"},{"full_name":"Willsch, Madita","last_name":"Willsch","first_name":"Madita"},{"last_name":"Michielsen","full_name":"Michielsen, Kristel","first_name":"Kristel"},{"full_name":"Papić, Zlatko","last_name":"Papić","first_name":"Zlatko"}],"article_type":"original","publisher":"Springer Nature","publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"scopus_import":"1","file":[{"file_size":2252107,"file_name":"2025_NaturePhysics_Vodeb.pdf","date_created":"2025-08-05T11:56:53Z","date_updated":"2025-08-05T11:56:53Z","content_type":"application/pdf","checksum":"b005ccf7448fee29c187cbc9b1944893","success":1,"creator":"dernst","relation":"main_file","access_level":"open_access","file_id":"20127"}]},{"acknowledgement":"We thank F. Hassani and M. Zemlicka for assistance with qubit design and high-power readout, respectively, and P. Winkel and I. Pop at Karlsruhe Institute of Technology for providing the JPA. This work was supported by the European Research Council under grant nos. 758053 (ERC StG QUNNECT) and 101089099 (ERC CoG cQEO), and the European Union’s Horizon 2020 research and innovation program under grant no. 899354 (FETopen SuperQuLAN). This research was funded in whole, or in part, by the Austrian Science Fund (FWF) DOI 10.55776/F71. L.Q. acknowledges generous support from the ISTFELLOW programme and G.A. is the recipient of a DOC fellowship of the Austrian Academy of Sciences at IST Austria. Open access funding provided by Institute of Science and Technology (IST Austria).","day":"01","volume":21,"publication":"Nature Physics","oa":1,"intvolume":"        21","year":"2025","corr_author":"1","OA_place":"publisher","language":[{"iso":"eng"}],"file_date_updated":"2025-04-16T08:09:43Z","date_created":"2025-02-23T23:01:57Z","_id":"19073","title":"All-optical superconducting qubit readout","quality_controlled":"1","article_type":"original","author":[{"first_name":"Georg M","orcid":"0000-0003-1397-7876","id":"3770C838-F248-11E8-B48F-1D18A9856A87","last_name":"Arnold","full_name":"Arnold, Georg M"},{"first_name":"Thomas","orcid":"0009-0001-2346-5236","id":"1fcd8497-dba3-11ea-a45e-c6fbd715f7c7","last_name":"Werner","full_name":"Werner, Thomas"},{"id":"47D26E34-F248-11E8-B48F-1D18A9856A87","full_name":"Sahu, Rishabh","last_name":"Sahu","first_name":"Rishabh","orcid":"0000-0001-6264-2162"},{"orcid":"0000-0001-8319-2148","first_name":"Lucky","last_name":"Kapoor","id":"84b9700b-15b2-11ec-abd3-831089e67615","full_name":"Kapoor, Lucky"},{"first_name":"Liu","orcid":"0000-0003-4345-4267","last_name":"Qiu","full_name":"Qiu, Liu","id":"45e99c0d-1eb1-11eb-9b96-ed8ab2983cac"},{"last_name":"Fink","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","full_name":"Fink, Johannes M","orcid":"0000-0001-8112-028X","first_name":"Johannes M"}],"publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"publisher":"Springer Nature","file":[{"date_created":"2025-04-16T08:09:43Z","date_updated":"2025-04-16T08:09:43Z","file_name":"2025_NaturePhysics_Arnold.pdf","content_type":"application/pdf","file_size":3396595,"checksum":"ab7469aca9e2e068eb78e5c5c1efaf7d","success":1,"access_level":"open_access","file_id":"19572","creator":"dernst","relation":"main_file"}],"scopus_import":"1","ec_funded":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publication_status":"published","fulldoi":"https://doi.org/10.1038/s41567-024-02741-4","date_updated":"2026-05-20T13:35:42Z","article_processing_charge":"Yes (via OA deal)","has_accepted_license":"1","department":[{"_id":"JoFi"}],"pmid":1,"article_number":"9470","project":[{"grant_number":"758053","name":"A Fiber Optic Transceiver for Superconducting Qubits","call_identifier":"H2020","_id":"26336814-B435-11E9-9278-68D0E5697425"},{"grant_number":"101089099","name":"Cavity Quantum Electro Optics: Microwave photonics with nonclassical states","_id":"bdadfa0d-d553-11ed-ba76-fb85edbd456a"},{"_id":"9B868D20-BA93-11EA-9121-9846C619BF3A","call_identifier":"H2020","grant_number":"899354","name":"Quantum Local Area Networks with Superconducting Qubits"},{"_id":"2671EB66-B435-11E9-9278-68D0E5697425","name":"Coherent on-chip conversion of superconducting qubit signals from microwaves to optical frequencies"},{"_id":"bdb108fd-d553-11ed-ba76-83dc74a9864f","name":"QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration of Superconducting Quantum Circuits","grant_number":"F07105"}],"status":"public","OA_type":"hybrid","isi":1,"doi":"10.1038/s41567-024-02741-4","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"date_published":"2025-03-01T00:00:00Z","citation":{"short":"G.M. Arnold, T. Werner, R. Sahu, L. Kapoor, L. Qiu, J.M. Fink, Nature Physics 21 (2025).","ieee":"G. M. Arnold, T. Werner, R. Sahu, L. Kapoor, L. Qiu, and J. M. Fink, “All-optical superconducting qubit readout,” <i>Nature Physics</i>, vol. 21. Springer Nature, 2025.","ista":"Arnold GM, Werner T, Sahu R, Kapoor L, Qiu L, Fink JM. 2025. All-optical superconducting qubit readout. Nature Physics. 21, 9470.","ama":"Arnold GM, Werner T, Sahu R, Kapoor L, Qiu L, Fink JM. All-optical superconducting qubit readout. <i>Nature Physics</i>. 2025;21. doi:<a href=\"https://doi.org/10.1038/s41567-024-02741-4\">10.1038/s41567-024-02741-4</a>","chicago":"Arnold, Georg M, Thomas Werner, Rishabh Sahu, Lucky Kapoor, Liu Qiu, and Johannes M Fink. “All-Optical Superconducting Qubit Readout.” <i>Nature Physics</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41567-024-02741-4\">https://doi.org/10.1038/s41567-024-02741-4</a>.","mla":"Arnold, Georg M., et al. “All-Optical Superconducting Qubit Readout.” <i>Nature Physics</i>, vol. 21, 9470, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41567-024-02741-4\">10.1038/s41567-024-02741-4</a>.","apa":"Arnold, G. M., Werner, T., Sahu, R., Kapoor, L., Qiu, L., &#38; Fink, J. M. (2025). All-optical superconducting qubit readout. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-024-02741-4\">https://doi.org/10.1038/s41567-024-02741-4</a>"},"ddc":["530"],"oa_version":"Published Version","external_id":{"pmid":["40093969"],"isi":["001417760400001"]},"type":"journal_article","month":"03","abstract":[{"lang":"eng","text":"The rapid development of superconducting quantum hardware is expected to run into substantial restrictions on scalability because error correction in a cryogenic environment has stringent input–output requirements. Classical data centres rely on fibre-optic interconnects to remove similar networking bottlenecks. In the same spirit, ultracold electro-optic links have been proposed and used to generate qubit control signals, or to replace cryogenic readout electronics. So far, these approaches have suffered from either low efficiency, low bandwidth or additional noise. Here we realize radio-over-fibre qubit readout at millikelvin temperatures. We use one device to simultaneously perform upconversion and downconversion between microwave and optical frequencies and so do not require any active or passive cryogenic microwave equipment. We demonstrate all-optical single-shot readout in a circulator-free readout scheme. Importantly, we do not observe any direct radiation impact on the qubit state, despite the absence of shielding elements. This compatibility between superconducting circuits and telecom-wavelength light is not only a prerequisite to establish modular quantum networks, but it is also relevant for multiplexed readout of superconducting photon detectors and classical superconducting logic."}],"related_material":{"record":[{"relation":"earlier_version","status":"public","id":"18953"},{"status":"public","id":"21863","relation":"dissertation_contains"}],"link":[{"description":"News on ISTA Website","relation":"press_release","url":"https://ista.ac.at/en/news/when-qubits-learn-the-language-of-fiberoptics/"}]}},{"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","ec_funded":1,"date_updated":"2025-09-30T10:47:36Z","fulldoi":"https://doi.org/10.1038/s41567-025-02792-1","publication_status":"published","has_accepted_license":"1","article_processing_charge":"Yes (via OA deal)","department":[{"_id":"EdHa"}],"pmid":1,"article_number":"078104","status":"public","project":[{"name":"Design Principles of Branching Morphogenesis","grant_number":"851288","_id":"05943252-7A3F-11EA-A408-12923DDC885E","call_identifier":"H2020"},{"call_identifier":"FWF","_id":"268294B6-B435-11E9-9278-68D0E5697425","name":"Active mechano-chemical description of the cell cytoskeleton","grant_number":"P31639"}],"isi":1,"OA_type":"hybrid","doi":"10.1038/s41567-025-02792-1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"date_published":"2025-02-28T00:00:00Z","citation":{"ama":"Xue S, Yang Q, Liberali P, Hannezo EB. Mechanochemical bistability of intestinal organoids enables robust morphogenesis. <i>Nature Physics</i>. 2025;21. doi:<a href=\"https://doi.org/10.1038/s41567-025-02792-1\">10.1038/s41567-025-02792-1</a>","chicago":"Xue, Shi-lei, Qiutan Yang, Prisca Liberali, and Edouard B Hannezo. “Mechanochemical Bistability of Intestinal Organoids Enables Robust Morphogenesis.” <i>Nature Physics</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41567-025-02792-1\">https://doi.org/10.1038/s41567-025-02792-1</a>.","ista":"Xue S, Yang Q, Liberali P, Hannezo EB. 2025. Mechanochemical bistability of intestinal organoids enables robust morphogenesis. Nature Physics. 21, 078104.","short":"S. Xue, Q. Yang, P. Liberali, E.B. Hannezo, Nature Physics 21 (2025).","ieee":"S. Xue, Q. Yang, P. Liberali, and E. B. Hannezo, “Mechanochemical bistability of intestinal organoids enables robust morphogenesis,” <i>Nature Physics</i>, vol. 21. Springer Nature, 2025.","mla":"Xue, Shi-lei, et al. “Mechanochemical Bistability of Intestinal Organoids Enables Robust Morphogenesis.” <i>Nature Physics</i>, vol. 21, 078104, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41567-025-02792-1\">10.1038/s41567-025-02792-1</a>.","apa":"Xue, S., Yang, Q., Liberali, P., &#38; Hannezo, E. B. (2025). Mechanochemical bistability of intestinal organoids enables robust morphogenesis. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-025-02792-1\">https://doi.org/10.1038/s41567-025-02792-1</a>"},"ddc":["530"],"oa_version":"Published Version","type":"journal_article","external_id":{"arxiv":["2403.19900"],"isi":["001434072800001"],"pmid":["40248571"]},"month":"02","abstract":[{"text":"Reproducible pattern and form generation during embryogenesis is poorly understood. Intestinal organoid morphogenesis involves a number of mechanochemical regulators such as cell-type-specific cytoskeletal forces and osmotically driven lumen volume changes. It is unclear how these forces are coordinated in time and space to ensure robust morphogenesis. Here we show how mechanosensitive feedback on cytoskeletal tension gives rise to morphological bistability in a minimal model of organoid morphogenesis. In the model, lumen volume changes can impact the epithelial shape via both direct mechanical and indirect mechanosensitive mechanisms. We find that both bulged and budded crypt states are possible and dependent on the history of volume changes. We test key modelling assumptions via biophysical and pharmacological experiments to demonstrate how bistability can explain experimental observations, such as the importance of the timing of lumen shrinkage and robustness of the final morphogenetic state to mechanical perturbations. This suggests that bistability arising from feedback between cellular tensions and fluid pressure could be a general mechanism that coordinates multicellular shape changes in developing systems.","lang":"eng"}],"PlanS_conform":"1","arxiv":1,"day":"28","acknowledgement":"We thank all members of the Hannezo and Liberali groups for fruitful discussions, as well as C. Schwayer, G. Quintas, L. Capolupo, D. Bruckner and D. Pinheiro for reading the manuscript. We also thank Y. Wu and X. Wu from the Yang group for performing experiments in the last rounds of revision and the So group at the National Institute of Biological Sciences, Beijing, for helping with the light-sheet time-lapse experiments. This work received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme via grant agreement no. 758617 (to P.L.), Swiss National Foundation (SNF) (no. POOP3_157531 to P.L.), the ERC under the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 851288 (to E.H.) and the Austrian Science Fund (FWF) (no. P 31639 to E.H.). This work was supported by the National Natural Science Foundation of China via grant no.3247060387 (to Q.Y.) and the Strategic Priority Research Program of the Chinese Academy of Sciences (no. XDB0820000 to Q.Y.) . Open access funding provided by Institute of Science and Technology (IST Austria).","publication":"Nature Physics","volume":21,"oa":1,"intvolume":"        21","year":"2025","language":[{"iso":"eng"}],"corr_author":"1","OA_place":"publisher","_id":"19373","date_created":"2025-03-09T23:01:28Z","file_date_updated":"2025-08-05T12:12:03Z","quality_controlled":"1","title":"Mechanochemical bistability of intestinal organoids enables robust morphogenesis","author":[{"first_name":"Shi-lei","last_name":"Xue","id":"31D2C804-F248-11E8-B48F-1D18A9856A87","full_name":"Xue, Shi-lei"},{"full_name":"Yang, Qiutan","last_name":"Yang","first_name":"Qiutan"},{"first_name":"Prisca","full_name":"Liberali, Prisca","last_name":"Liberali"},{"orcid":"0000-0001-6005-1561","first_name":"Edouard B","full_name":"Hannezo, Edouard B","last_name":"Hannezo","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87"}],"article_type":"original","publisher":"Springer Nature","publication_identifier":{"issn":["1745-2473"],"eissn":["1745-2481"]},"scopus_import":"1","file":[{"checksum":"fb5e59be145b95f9851d3d7c9dbb85e6","success":1,"relation":"main_file","creator":"dernst","access_level":"open_access","file_id":"20129","file_size":16302436,"date_updated":"2025-08-05T12:12:03Z","file_name":"2025_NaturePhysics_Xue.pdf","date_created":"2025-08-05T12:12:03Z","content_type":"application/pdf"}]},{"citation":{"mla":"Kalukula, Yohalie, et al. “The Actin Cortex Acts as a Mechanical Memory of Morphology in Confined Migrating Cells.” <i>Nature Physics</i>, vol. 21, Springer Nature, 2025, pp. 1451–61, doi:<a href=\"https://doi.org/10.1038/s41567-025-02980-z\">10.1038/s41567-025-02980-z</a>.","apa":"Kalukula, Y., Luciano, M., Simanov, G., Charras, G., Brückner, D., &#38; Gabriele, S. (2025). The actin cortex acts as a mechanical memory of morphology in confined migrating cells. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-025-02980-z\">https://doi.org/10.1038/s41567-025-02980-z</a>","short":"Y. Kalukula, M. Luciano, G. Simanov, G. Charras, D. Brückner, S. Gabriele, Nature Physics 21 (2025) 1451–1461.","ieee":"Y. Kalukula, M. Luciano, G. Simanov, G. Charras, D. Brückner, and S. Gabriele, “The actin cortex acts as a mechanical memory of morphology in confined migrating cells,” <i>Nature Physics</i>, vol. 21. Springer Nature, pp. 1451–1461, 2025.","chicago":"Kalukula, Yohalie, Marine Luciano, Gleb Simanov, Guillaume Charras, David Brückner, and Sylvain Gabriele. “The Actin Cortex Acts as a Mechanical Memory of Morphology in Confined Migrating Cells.” <i>Nature Physics</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41567-025-02980-z\">https://doi.org/10.1038/s41567-025-02980-z</a>.","ista":"Kalukula Y, Luciano M, Simanov G, Charras G, Brückner D, Gabriele S. 2025. The actin cortex acts as a mechanical memory of morphology in confined migrating cells. Nature Physics. 21, 1451–1461.","ama":"Kalukula Y, Luciano M, Simanov G, Charras G, Brückner D, Gabriele S. The actin cortex acts as a mechanical memory of morphology in confined migrating cells. <i>Nature Physics</i>. 2025;21:1451-1461. doi:<a href=\"https://doi.org/10.1038/s41567-025-02980-z\">10.1038/s41567-025-02980-z</a>"},"date_published":"2025-09-01T00:00:00Z","doi":"10.1038/s41567-025-02980-z","isi":1,"OA_type":"closed access","project":[{"_id":"34e2a5b5-11ca-11ed-8bc3-b2265616ef0b","name":"A mechano-chemical theory for stem cell fate decisions in organoid development","grant_number":"ALTF 343-2022"}],"status":"public","abstract":[{"text":"Cell migration in narrow microenvironments occurs in numerous physiological processes. It involves successive cycles of confinement and release that drive important morphological changes. However, it remains unclear whether migrating cells can retain a memory of their past morphological states that could potentially facilitate their navigation through confined spaces. We demonstrate that local geometry governs a switch between two cell morphologies, thereby facilitating cell passage through long and narrow gaps. We combined cell migration assays on standardized microsystems with biophysical modelling and biochemical perturbations to show that migrating cells have a long-term memory of past confinement events. The morphological cell states correlate across transitions through actin cortex remodelling. These findings indicate that mechanical memory in migrating cells plays an active role in their migratory potential in confined environments.","lang":"eng"}],"month":"09","external_id":{"isi":["001556019400001"]},"type":"journal_article","oa_version":"None","fulldoi":"https://doi.org/10.1038/s41567-025-02980-z","date_updated":"2025-12-30T09:34:11Z","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"EdHa"}],"article_processing_charge":"No","_id":"20259","date_created":"2025-08-31T22:01:33Z","page":"1451-1461","scopus_import":"1","publisher":"Springer Nature","publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"article_type":"original","author":[{"last_name":"Kalukula","full_name":"Kalukula, Yohalie","first_name":"Yohalie"},{"first_name":"Marine","full_name":"Luciano, Marine","last_name":"Luciano"},{"last_name":"Simanov","full_name":"Simanov, Gleb","first_name":"Gleb"},{"full_name":"Charras, Guillaume","last_name":"Charras","first_name":"Guillaume"},{"orcid":"0000-0001-7205-2975","first_name":"David","id":"e1e86031-6537-11eb-953a-f7ab92be508d","full_name":"Brückner, David","last_name":"Brückner"},{"first_name":"Sylvain","full_name":"Gabriele, Sylvain","last_name":"Gabriele"}],"quality_controlled":"1","title":"The actin cortex acts as a mechanical memory of morphology in confined migrating cells","publication":"Nature Physics","volume":21,"day":"01","acknowledgement":"We are grateful to members of S.G.’s laboratory for feedback and suggestions. We thank E. Hannezo, J. O. Rädler, M. Piel, O. du Roure and J. Heuvingh for inspiring discussions. Y.K. and S.G. acknowledge J. B. Braquenier from Nikon Instruments Belux and the Nikon BioImaging Lab in Leiden (the Netherlands) for their support with the Nikon Spatial Array Confocal enhanced-resolution confocal microscopy. We thank D. S. Herrador and M. Balland for their help in improving the microprinting method. D.B.B. was supported by the NOMIS Foundation as a NOMIS Fellow and by an EMBO Postdoctoral Fellowship (ALTF 343-2022). Y.K., M.L. and S.G. acknowledge funding from the University of Mons (FEDER Prostem Research Project no. 1510614, Wallonia DG06), the F.R.S.-FNRS (Epiforce Project no. T.0092.21, Cellsqueezer Project no. J.0061.23 and Optopattern Project no. U.NO26.22) and the Interreg projects ANTIRESI and MICROPLAITE, which are financially supported by Interreg France-Wallonie-Vlaanderen (Fonds Européen de Développement Régional). Y.K. and M.L. are financially supported by F.R.S.-FNRS as FRIA Grantee FNRS and Postdoctoral Fellow (Chargé de Recherches), respectively. Y.K. and S.G. acknowledge le Fonds pour la Recherche Médicale dans le Hainaut (FRMH). G.C. was supported by a grant from the Biotechnology and Biological Sciences Research Council (grant no. BB/V007483/1).","language":[{"iso":"eng"}],"corr_author":"1","year":"2025","intvolume":"        21"},{"publisher":"Springer Nature","publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"scopus_import":"1","quality_controlled":"1","title":"Single-cell migration along and against confined haptotactic gradients","author":[{"first_name":"Isabela Corina","full_name":"Fortunato, Isabela Corina","last_name":"Fortunato"},{"last_name":"Brückner","full_name":"Brückner, David","id":"e1e86031-6537-11eb-953a-f7ab92be508d","first_name":"David","orcid":"0000-0001-7205-2975"},{"full_name":"Grosser, Steffen","last_name":"Grosser","first_name":"Steffen"},{"first_name":"Rohit","full_name":"Nautiyal, Rohit","last_name":"Nautiyal"},{"first_name":"Leone","last_name":"Rossetti","full_name":"Rossetti, Leone"},{"last_name":"Bosch-Padrós","full_name":"Bosch-Padrós, Miquel","first_name":"Miquel"},{"last_name":"Trebicka","full_name":"Trebicka, Jonel","first_name":"Jonel"},{"full_name":"Roca-Cusachs, Pere","last_name":"Roca-Cusachs","first_name":"Pere"},{"full_name":"Sunyer, Raimon","last_name":"Sunyer","first_name":"Raimon"},{"orcid":"0000-0001-6005-1561","first_name":"Edouard B","full_name":"Hannezo, Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","last_name":"Hannezo"},{"last_name":"Trepat","full_name":"Trepat, Xavier","first_name":"Xavier"}],"article_type":"original","page":"1638-1647","_id":"20431","date_created":"2025-10-05T22:01:36Z","year":"2025","language":[{"iso":"eng"}],"OA_place":"repository","corr_author":"1","oa":1,"intvolume":"        21","volume":21,"publication":"Nature Physics","day":"01","acknowledgement":"We thank all the members of our groups for discussions and support. We thank A. Menéndez, S. Usieto, M. Purciolas and E. Coderch for technical assistance. We thank G. Charras (London Centre for Nanotechnology, UK) and M. Sheetz (Columbia University, USA) for sharing cells used in this work. We thank J. Ivaska (University of Turku, Finland) for sharing integrin α5-GFP DNA plasmid. We thank P. Guillamat for technical advice and A. Labernardie for providing the microfluidic channels. We thank M. Gómez-González for sharing the 2D traction microscopy algorithm. Finally, we thank P. Guillamat, J. Abenza, G. Ceada, L. Faure, E. Dalaka, M. Matejčić, A. Beedle, I. Granero, O. Baguer, A. Albajar and N. Chahare for discussions. This paper was funded by the Generalitat de Catalunya (Grant Nos. AGAUR SGR-2017-01602 to X.T. and 2021 SGR 00523 to R.S. and the CERCA Programme and ICREA Academia awards to P.R.-C.), the Spanish Ministry for Science and Innovation MICCINN/FEDER (Grant Nos. PID2021-128635NB-I00, MCIN/AEI/10.13039/501100011033 and ERDF-EU A way of making Europe to X.T., PID2021-128674OB-I00 and CNS2022-135533 to R.S. and PID2019-110298GB-I00 to P.R.-C.), the European Research Council (Grant Nos. 101097753 to P.R.-C. and Adv-883739 to X.T.), Fundació la Marató de TV3 (Project Award 201903-30-31-32 to X.T.), the European Commission (Grant No. H2020-FETPROACT-01-2016-731957 to P.R.-C. and X.T.) and La Caixa Foundation (Grant No. LCF/PR/HR20/52400004 to P.R.-C. and X.T.). R.S. is a Serra-Hunter fellow. D.B.B. was supported by the NOMIS foundation as a NOMIS fellow, by the European Molecular Biology Organization (Postdoctoral Fellowship ALTF 343-2022) and by the Austrian Academy of Sciences through an APART-MINT Fellowship. I.C.F. acknowledges support from the European Foundation for the Study of Chronic Liver Failure. IBEC is recipient of a Severo Ochoa Award of Excellence from MINECO.","month":"10","abstract":[{"text":"Haptotaxis is the process of directed cell migration along gradients of extracellular matrix density and is central to morphogenesis, immune responses and cancer invasion. It is commonly assumed that cells respond to these gradients by migrating directionally towards the regions of highest ligand density. In contrast with this view, here we show that cells exposed to micropatterned fibronectin gradients exhibit a wide range of complex trajectories, including directed haptotactic migration up the gradient but also linear oscillations and circles with extended periods of migration down the gradient. To explain this behaviour, we developed a biophysical model of haptotactic cell migration based on a coarse-grained molecular clutch model coupled to persistent stochastic polarity dynamics. Although initial haptotactic migration is explained by the differential friction at the front and back of the cell, the observed complex trajectories over longer timescales arise from the interplay between differential friction, persistence and physical confinement. Overall, our study reveals that confinement and persistence modulate the ability of cells to sense and respond to haptotactic cues and provides a framework for understanding how cells navigate complex environments.","lang":"eng"}],"oa_version":"Preprint","type":"journal_article","external_id":{"isi":["001581659900001"]},"date_published":"2025-10-01T00:00:00Z","citation":{"short":"I.C. Fortunato, D. Brückner, S. Grosser, R. Nautiyal, L. Rossetti, M. Bosch-Padrós, J. Trebicka, P. Roca-Cusachs, R. Sunyer, E.B. Hannezo, X. Trepat, Nature Physics 21 (2025) 1638–1647.","ieee":"I. C. Fortunato <i>et al.</i>, “Single-cell migration along and against confined haptotactic gradients,” <i>Nature Physics</i>, vol. 21. Springer Nature, pp. 1638–1647, 2025.","chicago":"Fortunato, Isabela Corina, David Brückner, Steffen Grosser, Rohit Nautiyal, Leone Rossetti, Miquel Bosch-Padrós, Jonel Trebicka, et al. “Single-Cell Migration along and against Confined Haptotactic Gradients.” <i>Nature Physics</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41567-025-03015-3\">https://doi.org/10.1038/s41567-025-03015-3</a>.","ista":"Fortunato IC, Brückner D, Grosser S, Nautiyal R, Rossetti L, Bosch-Padrós M, Trebicka J, Roca-Cusachs P, Sunyer R, Hannezo EB, Trepat X. 2025. Single-cell migration along and against confined haptotactic gradients. Nature Physics. 21, 1638–1647.","ama":"Fortunato IC, Brückner D, Grosser S, et al. Single-cell migration along and against confined haptotactic gradients. <i>Nature Physics</i>. 2025;21:1638-1647. doi:<a href=\"https://doi.org/10.1038/s41567-025-03015-3\">10.1038/s41567-025-03015-3</a>","apa":"Fortunato, I. C., Brückner, D., Grosser, S., Nautiyal, R., Rossetti, L., Bosch-Padrós, M., … Trepat, X. (2025). Single-cell migration along and against confined haptotactic gradients. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-025-03015-3\">https://doi.org/10.1038/s41567-025-03015-3</a>","mla":"Fortunato, Isabela Corina, et al. “Single-Cell Migration along and against Confined Haptotactic Gradients.” <i>Nature Physics</i>, vol. 21, Springer Nature, 2025, pp. 1638–47, doi:<a href=\"https://doi.org/10.1038/s41567-025-03015-3\">10.1038/s41567-025-03015-3</a>."},"main_file_link":[{"url":"https://doi.org/10.1101/2024.12.02.626413","open_access":"1"}],"status":"public","project":[{"_id":"34e2a5b5-11ca-11ed-8bc3-b2265616ef0b","grant_number":"ALTF 343-2022","name":"A mechano-chemical theory for stem cell fate decisions in organoid development"}],"OA_type":"green","doi":"10.1038/s41567-025-03015-3","isi":1,"article_processing_charge":"No","department":[{"_id":"EdHa"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-01-05T14:26:28Z","fulldoi":"https://doi.org/10.1038/s41567-025-03015-3","publication_status":"published"},{"abstract":[{"lang":"eng","text":"A rapidly increasing body of work reporting phenomena associated with lattice vibrations carrying angular momentum has led to the emergence of the field of chiral phonons. Some of these properties, such as the phonon magnetic moment, also occur in achiral phonons that are circularly or elliptically polarized, while the presence of chirality has additional implications for the types of interaction allowed between the phonons and light, electrons and other quasiparticles. In this Perspective we introduce a framework for classifying phonons with angular momentum, and provide illustrations of the different types using examples from the recent literature. Specifically, we suggest the term ‘axial phonon’ to encompass all phonons that carry angular momentum, real or pseudo, and reserve the term ‘chiral phonon’ for those phonons that break improper rotational symmetry. We hope that this scheme provides clarification on the matter of phonon chirality and will serve as a guide for future research."}],"month":"10","external_id":{"isi":["001575765100001"]},"type":"journal_article","oa_version":"None","citation":{"apa":"Juraschek, D. M., Geilhufe, R. M., Zhu, H., Basini, M., Baum, P., Baydin, A., … Zhang, L. (2025). Chiral phonons. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-025-03001-9\">https://doi.org/10.1038/s41567-025-03001-9</a>","mla":"Juraschek, Dominik M., et al. “Chiral Phonons.” <i>Nature Physics</i>, vol. 21, Springer Nature, 2025, pp. 1532–40, doi:<a href=\"https://doi.org/10.1038/s41567-025-03001-9\">10.1038/s41567-025-03001-9</a>.","ista":"Juraschek DM, Geilhufe RM, Zhu H, Basini M, Baum P, Baydin A, Chaudhary S, Fechner M, Flebus B, Grissonnanche G, Kirilyuk AI, Lemeshko M, Maehrlein SF, Mignolet M, Murakami S, Niu Q, Nowak U, Romao CP, Rostami H, Satoh T, Spaldin NA, Ueda H, Zhang L. 2025. Chiral phonons. Nature Physics. 21, 1532–1540.","chicago":"Juraschek, Dominik M., R. Matthias Geilhufe, Hanyu Zhu, Martina Basini, Peter Baum, Andrey Baydin, Swati Chaudhary, et al. “Chiral Phonons.” <i>Nature Physics</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41567-025-03001-9\">https://doi.org/10.1038/s41567-025-03001-9</a>.","ama":"Juraschek DM, Geilhufe RM, Zhu H, et al. Chiral phonons. <i>Nature Physics</i>. 2025;21:1532-1540. doi:<a href=\"https://doi.org/10.1038/s41567-025-03001-9\">10.1038/s41567-025-03001-9</a>","ieee":"D. M. Juraschek <i>et al.</i>, “Chiral phonons,” <i>Nature Physics</i>, vol. 21. Springer Nature, pp. 1532–1540, 2025.","short":"D.M. Juraschek, R.M. Geilhufe, H. Zhu, M. Basini, P. Baum, A. Baydin, S. Chaudhary, M. Fechner, B. Flebus, G. Grissonnanche, A.I. Kirilyuk, M. Lemeshko, S.F. Maehrlein, M. Mignolet, S. Murakami, Q. Niu, U. Nowak, C.P. Romao, H. Rostami, T. Satoh, N.A. Spaldin, H. Ueda, L. Zhang, Nature Physics 21 (2025) 1532–1540."},"date_published":"2025-10-01T00:00:00Z","isi":1,"OA_type":"closed access","doi":"10.1038/s41567-025-03001-9","status":"public","department":[{"_id":"MiLe"}],"article_processing_charge":"No","publication_status":"published","fulldoi":"https://doi.org/10.1038/s41567-025-03001-9","date_updated":"2026-01-05T13:25:59Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","publication_identifier":{"issn":["1745-2473"],"eissn":["1745-2481"]},"publisher":"Springer Nature","author":[{"first_name":"Dominik M.","last_name":"Juraschek","full_name":"Juraschek, Dominik M."},{"last_name":"Geilhufe","full_name":"Geilhufe, R. Matthias","first_name":"R. Matthias"},{"first_name":"Hanyu","last_name":"Zhu","full_name":"Zhu, Hanyu"},{"full_name":"Basini, Martina","last_name":"Basini","first_name":"Martina"},{"full_name":"Baum, Peter","last_name":"Baum","first_name":"Peter"},{"first_name":"Andrey","full_name":"Baydin, Andrey","last_name":"Baydin"},{"last_name":"Chaudhary","full_name":"Chaudhary, Swati","first_name":"Swati"},{"last_name":"Fechner","full_name":"Fechner, Michael","first_name":"Michael"},{"first_name":"Benedetta","last_name":"Flebus","full_name":"Flebus, Benedetta"},{"first_name":"Gael","last_name":"Grissonnanche","full_name":"Grissonnanche, Gael"},{"full_name":"Kirilyuk, Andrei I.","last_name":"Kirilyuk","first_name":"Andrei I."},{"id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","full_name":"Lemeshko, Mikhail","last_name":"Lemeshko","first_name":"Mikhail","orcid":"0000-0002-6990-7802"},{"first_name":"Sebastian F.","last_name":"Maehrlein","full_name":"Maehrlein, Sebastian F."},{"last_name":"Mignolet","full_name":"Mignolet, Maxime","first_name":"Maxime"},{"first_name":"Shuichi","full_name":"Murakami, Shuichi","last_name":"Murakami"},{"last_name":"Niu","full_name":"Niu, Qian","first_name":"Qian"},{"full_name":"Nowak, Ulrich","last_name":"Nowak","first_name":"Ulrich"},{"full_name":"Romao, Carl P.","last_name":"Romao","first_name":"Carl P."},{"first_name":"Habib","full_name":"Rostami, Habib","last_name":"Rostami"},{"full_name":"Satoh, Takuya","last_name":"Satoh","first_name":"Takuya"},{"full_name":"Spaldin, Nicola A.","last_name":"Spaldin","first_name":"Nicola A."},{"full_name":"Ueda, Hiroki","last_name":"Ueda","first_name":"Hiroki"},{"full_name":"Zhang, Lifa","last_name":"Zhang","first_name":"Lifa"}],"article_type":"original","title":"Chiral phonons","quality_controlled":"1","_id":"20432","page":"1532-1540","date_created":"2025-10-05T22:01:37Z","language":[{"iso":"eng"}],"year":"2025","intvolume":"        21","publication":"Nature Physics","volume":21,"acknowledgement":"We thank A. V. Balatsky, E. Bousquet, A. Disa, S. Kamba, L. Klebl, R. Merlin, A. Srivastava, A. Stroppa, M. Udina, P. Wong and D. Xiao for valuable discussions. M.B. acknowledges support from SNSF Ambizione project number PZ00P2_216089. P.B. and U.N. acknowledge funding from the Deutsche Forschungsgemeinschaft (grant number 541503763). B.F. acknowledges support from the National Science Foundation under grant number NSF DMR-2144086. G.G. acknowledges support from STeP2 number ANR-22-EXES-0013, QuantExt number ANR-23-CE30-0001-01, Audace CEA number ANR-24-RRII-0004 and the École Polytechnique foundation. A.I.K. acknowledges the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO-I) for their financial contribution, including the support of the HFML-FELIX Laboratory. D.M.J. acknowledges support from Tel Aviv University and ERC Starting Grant CHIRALPHONONICS grant number 101166037. S.F.M. acknowledges funding from the Deutsche Forschungsgemeinschaft (grant number 469405347). C.P.R. and N.A.S. were supported by ETH Zurich and by the European Union and Horizon 2020, grant agreement numbers 810451 and 101030352. R.M.G. acknowledges support from the Swedish Research Council (VR starting grant number 2022-03350), the Olle Engkvist Foundation (grant number 229-0443), the Royal Physiographic Society in Lund (Horisont), the Knut and Alice Wallenberg Foundation (grant number 2023.0087) and Chalmers University of Technology via the Department of Physics and the Areas of Advance Nano and Materials Science. Q.N. is supported by the National Natural Science Foundation of China (grant number 12234017) and the National Key Research and Development Program of China (grant number 2023YFA1406300). H.R. acknowledges funding from the Engineering and Physical Sciences Research Council (grant number UKRI122) and Royal Society (grant number IES\\R2\\242309). T.S. acknowledges support from MEXT X-NICS (grant number JPJ011438), NINS OML Project (grant number OML012301) and JST CREST (grant number JPMJCR24R5). H.Z. acknowledges support from the Welch Foundation (grant number C-2128) and the National Science Foundation (grant number DMR-2240106). We acknowledge support from the Centre Européen de Calcul Atomique et Moléculaire (CECAM) in connection to organizing the workshop \"Chiral Phonons in Quantum Materials\", held in 2023, where the idea for this paper emerged.","day":"01"},{"abstract":[{"lang":"eng","text":"Quasicrystals are ordered but not periodic, which makes them fascinating objects at the interface between order and disorder. Experiments with ultracold atoms zoom in on this interface by driving a quasicrystal and exploring its fractal properties."}],"month":"01","type":"journal_article","oa_version":"None","citation":{"apa":"Leonard, J. (2024). A kicked quasicrystal. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-023-02357-0\">https://doi.org/10.1038/s41567-023-02357-0</a>","mla":"Leonard, Julian. “A Kicked Quasicrystal.” <i>Nature Physics</i>, vol. 20, no. 3, Springer Nature, 2024, pp. 351–52, doi:<a href=\"https://doi.org/10.1038/s41567-023-02357-0\">10.1038/s41567-023-02357-0</a>.","ista":"Leonard J. 2024. A kicked quasicrystal. Nature Physics. 20(3), 351–352.","chicago":"Leonard, Julian. “A Kicked Quasicrystal.” <i>Nature Physics</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41567-023-02357-0\">https://doi.org/10.1038/s41567-023-02357-0</a>.","ama":"Leonard J. A kicked quasicrystal. <i>Nature Physics</i>. 2024;20(3):351-352. doi:<a href=\"https://doi.org/10.1038/s41567-023-02357-0\">10.1038/s41567-023-02357-0</a>","short":"J. Leonard, Nature Physics 20 (2024) 351–352.","ieee":"J. Leonard, “A kicked quasicrystal,” <i>Nature Physics</i>, vol. 20, no. 3. Springer Nature, pp. 351–352, 2024."},"date_published":"2024-01-19T00:00:00Z","doi":"10.1038/s41567-023-02357-0","status":"public","article_processing_charge":"No","issue":"3","publication_status":"published","date_updated":"2024-10-14T07:54:20Z","fulldoi":"https://doi.org/10.1038/s41567-023-02357-0","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","publication_identifier":{"issn":["1745-2473"],"eissn":["1745-2481"]},"publisher":"Springer Nature","article_type":"letter_note","author":[{"full_name":"Leonard, Julian","id":"b75b3f45-7995-11ef-9bfd-9a9cd02c3577","last_name":"Leonard","orcid":"0000-0003-3696-6870","first_name":"Julian"}],"title":"A kicked quasicrystal","quality_controlled":"1","extern":"1","page":"351-352","_id":"18187","date_created":"2024-10-07T11:45:17Z","language":[{"iso":"eng"}],"year":"2024","intvolume":"        20","publication":"Nature Physics","volume":20,"day":"19"},{"OA_type":"hybrid","dataavailabilitystatement":"The simulation data presented in this work are available from the University College London public data repository at https://doi.org/10.5522/04/24754527 (ref. 74). Live-cell imaging of FtsZ rings data presented in this work are from ref. 23. High-speed atomic force microscopy data presented in this work are from ref. 9. Total internal reflection fluorescence microscopy data presented in this work are from refs. 37,75,76","isi":1,"doi":"10.1038/s41567-024-02597-8","status":"public","project":[{"_id":"fc38323b-9c52-11eb-aca3-ff8afb4a011d","grant_number":"P34607","name":"In vitro reconstitution of bacterial cell division"},{"_id":"eba2549b-77a9-11ec-83b8-a81e493eae4e","call_identifier":"H2020","name":"Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines","grant_number":"802960"}],"citation":{"mla":"Vanhille-Campos, Christian Eduardo, et al. “Self-Organization of Mortal Filaments and Its Role in Bacterial Division Ring Formation.” <i>Nature Physics</i>, vol. 20, Springer Nature, 2024, pp. 1670–78, doi:<a href=\"https://doi.org/10.1038/s41567-024-02597-8\">10.1038/s41567-024-02597-8</a>.","apa":"Vanhille-Campos, C. E., Whitley, K. D., Radler, P., Loose, M., Holden, S., &#38; Šarić, A. (2024). Self-organization of mortal filaments and its role in bacterial division ring formation. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-024-02597-8\">https://doi.org/10.1038/s41567-024-02597-8</a>","ista":"Vanhille-Campos CE, Whitley KD, Radler P, Loose M, Holden S, Šarić A. 2024. Self-organization of mortal filaments and its role in bacterial division ring formation. Nature Physics. 20, 1670–1678.","ama":"Vanhille-Campos CE, Whitley KD, Radler P, Loose M, Holden S, Šarić A. Self-organization of mortal filaments and its role in bacterial division ring formation. <i>Nature Physics</i>. 2024;20:1670-1678. doi:<a href=\"https://doi.org/10.1038/s41567-024-02597-8\">10.1038/s41567-024-02597-8</a>","chicago":"Vanhille-Campos, Christian Eduardo, Kevin D. Whitley, Philipp Radler, Martin Loose, Séamus Holden, and Anđela Šarić. “Self-Organization of Mortal Filaments and Its Role in Bacterial Division Ring Formation.” <i>Nature Physics</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41567-024-02597-8\">https://doi.org/10.1038/s41567-024-02597-8</a>.","short":"C.E. Vanhille-Campos, K.D. Whitley, P. Radler, M. Loose, S. Holden, A. Šarić, Nature Physics 20 (2024) 1670–1678.","ieee":"C. E. Vanhille-Campos, K. D. Whitley, P. Radler, M. Loose, S. Holden, and A. Šarić, “Self-organization of mortal filaments and its role in bacterial division ring formation,” <i>Nature Physics</i>, vol. 20. Springer Nature, pp. 1670–1678, 2024."},"ddc":["570"],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"date_published":"2024-10-01T00:00:00Z","type":"journal_article","external_id":{"pmid":["39416851"],"isi":["001289394500005"]},"das_tickbox":"1","oa_version":"Published Version","abstract":[{"text":"Filaments in the cell commonly treadmill. Driven by energy consumption, they grow on one end while shrinking on the other, causing filaments to appear motile even though individual proteins remain static. This process is characteristic of cytoskeletal filaments and leads to collective filament self-organization. Here we show that treadmilling drives filament nematic ordering by dissolving misaligned filaments. Taking the bacterial FtsZ protein involved in cell division as an example, we show that this mechanism aligns FtsZ filaments in vitro and drives the organization of the division ring in living Bacillus subtilis cells. We find that ordering via local dissolution also allows the system to quickly respond to chemical and geometrical biases in the cell, enabling us to quantitatively explain the ring formation dynamics in vivo. Beyond FtsZ and other cytoskeletal filaments, our study identifies a mechanism for self-organization via constant birth and death of energy-consuming filaments.","lang":"eng"}],"related_material":{"record":[{"status":"public","id":"22988","relation":"research_data"}]},"month":"10","publication_status":"published","fulldoi":"https://doi.org/10.1038/s41567-024-02597-8","date_updated":"2026-09-24T10:58:39Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","ec_funded":1,"researchdata_availability":"yes","department":[{"_id":"AnSa"},{"_id":"MaLo"}],"article_processing_charge":"Yes (in subscription journal)","has_accepted_license":"1","pmid":1,"APC_amount":"12348 EUR","supplementarymaterial":"yes","popular_science":"1","file_date_updated":"2025-04-14T06:06:35Z","_id":"17460","page":"1670-1678","date_created":"2024-08-25T22:01:08Z","author":[{"first_name":"Christian Eduardo","full_name":"Vanhille-Campos, Christian Eduardo","last_name":"Vanhille-Campos","id":"3adeca52-9313-11ed-b1ac-c170b2505714"},{"full_name":"Whitley, Kevin D.","last_name":"Whitley","first_name":"Kevin D."},{"last_name":"Radler","id":"40136C2A-F248-11E8-B48F-1D18A9856A87","full_name":"Radler, Philipp","orcid":"0000-0001-9198-2182 ","first_name":"Philipp"},{"first_name":"Martin","orcid":"0000-0001-7309-9724","id":"462D4284-F248-11E8-B48F-1D18A9856A87","full_name":"Loose, Martin","last_name":"Loose"},{"first_name":"Séamus","last_name":"Holden","full_name":"Holden, Séamus"},{"orcid":"0000-0002-7854-2139","first_name":"Anđela","full_name":"Šarić, Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","last_name":"Šarić"}],"article_type":"original","title":"Self-organization of mortal filaments and its role in bacterial division ring formation","quality_controlled":"1","file":[{"content_type":"application/pdf","date_created":"2025-04-14T06:06:35Z","date_updated":"2025-04-14T06:06:35Z","file_name":"2024_NaturePhysics_VanhilleCampos.pdf","file_size":8058249,"file_id":"19556","access_level":"open_access","creator":"dernst","relation":"main_file","success":1,"checksum":"c4842152e2b90d67f48ea8c9ed7c473b"}],"scopus_import":"1","publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"publisher":"Springer Nature","acknowledgement":"We thank I. Palaia (ISTA) for useful discussions and K. Lim and R. W. Wong (WPI-Nano Life Science Institute, Kanazawa University) for providing access to HS-AFM. We would like to thank B. Prats Mateu (MSD Austria, Vienna) for providing the HS-AFM data. This work was supported by the Royal Society (grant no. UF160266; C.V.-C. and A.Š.), the European Union’s Horizon 2020 Research and Innovation Programme (grant no. 802960; A.Š.), the Austrian Science Fund (FWF) Stand-Alone P34607 (M.L.) and a Wellcome Trust and Royal Society Sir Henry Dale Fellowship (grant no. 206670/Z/17/Z; S.H. and K.D.W.).","day":"01","publication":"Nature Physics","volume":20,"intvolume":"        20","oa":1,"OA_place":"publisher","corr_author":"1","language":[{"iso":"eng"}],"year":"2024"},{"department":[{"_id":"BjHo"}],"article_processing_charge":"No","publication_status":"published","fulldoi":"https://doi.org/10.1038/s41567-024-02513-0","date_updated":"2026-10-01T07:50:32Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","researchdata_availability":"yes","external_id":{"isi":["001232300600001"]},"type":"journal_article","oa_version":"None","das_tickbox":"1","abstract":[{"text":"The onset of turbulence in pipe flow has defied detailed understanding ever since the first observations of the spatially heterogeneous nature of the transition. Recent theoretical studies and experiments in simpler, shear-driven flows suggest that the onset of turbulence is a directed-percolation non-equilibrium phase transition, but whether these findings are generic and also apply to open or pressure-driven flows is unknown. In pipe flow, the extremely long time scales near the transition make direct observations of critical behaviour virtually impossible. Here we find a technical solution to that limitation and show that the universality class of the transition is directed percolation, from which a jammed phase of puffs emerges above the critical point. Our method is to experimentally characterize all pairwise interactions between localized patches of turbulence puffs and use these interactions as input for renormalization group and computer simulations of minimal models that extrapolate to long length and time scales. The strong interactions in the jamming regime enable us to explicitly measure the turbulent fraction and confirm model predictions. Our work shows that directed-percolation scaling applies beyond simple closed shear flows and underscores how statistical mechanics can lead to profound, quantitative and predictive insights on turbulent flows and their phases.","lang":"eng"}],"related_material":{"record":[{"id":"23012","status":"public","relation":"research_data"}]},"month":"08","doi":"10.1038/s41567-024-02513-0","dataavailabilitystatement":"All experimental data presented in this article are available online in the Zenodo repository at https://doi.org/10.5281/zenodo.10308791","isi":1,"project":[{"name":"Revisiting the Turbulence Problem Using Statistical Mechanics","grant_number":"662960","_id":"238598C6-32DE-11EA-91FC-C7463DDC885E"}],"status":"public","citation":{"mla":"Lemoult, Grégoire M., et al. “Directed Percolation and Puff Jamming near the Transition to Pipe Turbulence.” <i>Nature Physics</i>, vol. 20, Springer Nature, 2024, pp. 1339–45, doi:<a href=\"https://doi.org/10.1038/s41567-024-02513-0\">10.1038/s41567-024-02513-0</a>.","apa":"Lemoult, G. M., Vasudevan, M., Shih, H. Y., Linga, G., Mathiesen, J., Goldenfeld, N., &#38; Hof, B. (2024). Directed percolation and puff jamming near the transition to pipe turbulence. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-024-02513-0\">https://doi.org/10.1038/s41567-024-02513-0</a>","ieee":"G. M. Lemoult <i>et al.</i>, “Directed percolation and puff jamming near the transition to pipe turbulence,” <i>Nature Physics</i>, vol. 20. Springer Nature, pp. 1339–1345, 2024.","short":"G.M. Lemoult, M. Vasudevan, H.Y. Shih, G. Linga, J. Mathiesen, N. Goldenfeld, B. Hof, Nature Physics 20 (2024) 1339–1345.","ama":"Lemoult GM, Vasudevan M, Shih HY, et al. Directed percolation and puff jamming near the transition to pipe turbulence. <i>Nature Physics</i>. 2024;20:1339-1345. doi:<a href=\"https://doi.org/10.1038/s41567-024-02513-0\">10.1038/s41567-024-02513-0</a>","chicago":"Lemoult, Grégoire M, Mukund Vasudevan, Hong Yan Shih, Gaute Linga, Joachim Mathiesen, Nigel Goldenfeld, and Björn Hof. “Directed Percolation and Puff Jamming near the Transition to Pipe Turbulence.” <i>Nature Physics</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41567-024-02513-0\">https://doi.org/10.1038/s41567-024-02513-0</a>.","ista":"Lemoult GM, Vasudevan M, Shih HY, Linga G, Mathiesen J, Goldenfeld N, Hof B. 2024. Directed percolation and puff jamming near the transition to pipe turbulence. Nature Physics. 20, 1339–1345."},"date_published":"2024-08-01T00:00:00Z","intvolume":"        20","corr_author":"1","language":[{"iso":"eng"}],"year":"2024","acknowledgement":"We gratefully acknowledge the assistance of J. M. Lopez with DNSs at an early stage of this work. This work was partially supported by two grants from the Simons Foundation (grant nos. 662985 (N.G.) and 662960 (B.H.)) and by Ministry of Science and Technology, Taiwan (grant nos. MOST 109-2112-M-001-017-MY3 and MOST 111-2112-M-001-027-MY3 (H.-Y.S.)). Part of this work was performed using computing resources of CRIANN (Normandy, France).","day":"01","volume":20,"publication":"Nature Physics","author":[{"first_name":"Grégoire M","id":"4787FE80-F248-11E8-B48F-1D18A9856A87","last_name":"Lemoult","full_name":"Lemoult, Grégoire M"},{"last_name":"Vasudevan","full_name":"Vasudevan, Mukund","id":"3C5A959A-F248-11E8-B48F-1D18A9856A87","first_name":"Mukund"},{"first_name":"Hong Yan","last_name":"Shih","full_name":"Shih, Hong Yan"},{"first_name":"Gaute","last_name":"Linga","full_name":"Linga, Gaute"},{"last_name":"Mathiesen","full_name":"Mathiesen, Joachim","first_name":"Joachim"},{"last_name":"Goldenfeld","full_name":"Goldenfeld, Nigel","first_name":"Nigel"},{"first_name":"Björn","orcid":"0000-0003-2057-2754","last_name":"Hof","id":"3A374330-F248-11E8-B48F-1D18A9856A87","full_name":"Hof, Björn"}],"article_type":"original","title":"Directed percolation and puff jamming near the transition to pipe turbulence","quality_controlled":"1","scopus_import":"1","publication_identifier":{"issn":["1745-2473"],"eissn":["1745-2481"]},"publisher":"Springer Nature","supplementarymaterial":"yes","_id":"17128","page":"1339-1345","date_created":"2024-06-09T22:01:03Z"},{"volume":20,"publication":"Nature Physics","acknowledgement":"We would like to thank A. McDougall, E. Hannezo and the Heisenberg lab for fruitful discussions and reagents. We also thank E. Munro for the iMyo-YFP and Bra>iMyo-mScarlet constructs. This research was supported by the Scientific Service Units of the Institute of Science and Technology Austria through resources provided by the Electron Microscopy Facility, Imaging and Optics Facility and the Nanofabrication Facility. This work was supported by a Joint Project Grant from the FWF (I 3601-B27).","day":"01","corr_author":"1","language":[{"iso":"eng"}],"year":"2024","acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"Bio"},{"_id":"NanoFab"}],"intvolume":"        20","oa":1,"file_date_updated":"2024-07-16T12:12:43Z","date_created":"2024-01-21T23:00:57Z","_id":"14846","page":"310-321","supplementarymaterial":"yes","file":[{"checksum":"7891ebe7c900ae47469ab127031dd1ec","success":1,"creator":"dernst","relation":"main_file","access_level":"open_access","file_id":"17267","file_size":9897883,"file_name":"2024_NaturePhysics_CaballeroMancebo.pdf","date_updated":"2024-07-16T12:12:43Z","date_created":"2024-07-16T12:12:43Z","content_type":"application/pdf"}],"scopus_import":"1","publication_identifier":{"issn":["1745-2473"],"eissn":["1745-2481"]},"publisher":"Springer Nature","author":[{"full_name":"Caballero Mancebo, Silvia","last_name":"Caballero Mancebo","id":"2F1E1758-F248-11E8-B48F-1D18A9856A87","first_name":"Silvia","orcid":"0000-0002-5223-3346"},{"last_name":"Shinde","full_name":"Shinde, Rushikesh","first_name":"Rushikesh"},{"first_name":"Madison","orcid":"0000-0002-8176-4824","last_name":"Bolger-Munro","id":"516F03FA-93A3-11EA-A7C5-D6BE3DDC885E","full_name":"Bolger-Munro, Madison"},{"orcid":"0000-0002-3415-4628","first_name":"Matilda","last_name":"Peruzzo","id":"3F920B30-F248-11E8-B48F-1D18A9856A87","full_name":"Peruzzo, Matilda"},{"first_name":"Gregory","last_name":"Szep","id":"4BFB7762-F248-11E8-B48F-1D18A9856A87","full_name":"Szep, Gregory"},{"id":"2705C766-9FE2-11EA-B224-C6773DDC885E","last_name":"Steccari","full_name":"Steccari, Irene","first_name":"Irene"},{"full_name":"Labrousse Arias, David","id":"CD573DF4-9ED3-11E9-9D77-3223E6697425","last_name":"Labrousse Arias","first_name":"David"},{"last_name":"Zheden","id":"39C5A68A-F248-11E8-B48F-1D18A9856A87","full_name":"Zheden, Vanessa","orcid":"0000-0002-9438-4783","first_name":"Vanessa"},{"id":"4515C308-F248-11E8-B48F-1D18A9856A87","last_name":"Merrin","full_name":"Merrin, Jack","first_name":"Jack","orcid":"0000-0001-5145-4609"},{"first_name":"Andrew","last_name":"Callan-Jones","full_name":"Callan-Jones, Andrew"},{"full_name":"Voituriez, Raphaël","last_name":"Voituriez","first_name":"Raphaël"},{"full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg","orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J"}],"article_type":"original","title":"Friction forces determine cytoplasmic reorganization and shape changes of ascidian oocytes upon fertilization","quality_controlled":"1","publication_status":"published","fulldoi":"https://doi.org/10.1038/s41567-023-02302-1","date_updated":"2026-10-01T08:33:51Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","researchdata_availability":"yes","pmid":1,"department":[{"_id":"CaHe"},{"_id":"JoFi"},{"_id":"MiSi"},{"_id":"EM-Fac"},{"_id":"NanoFab"}],"article_processing_charge":"Yes (in subscription journal)","has_accepted_license":"1","ddc":["530"],"citation":{"mla":"Caballero Mancebo, Silvia, et al. “Friction Forces Determine Cytoplasmic Reorganization and Shape Changes of Ascidian Oocytes upon Fertilization.” <i>Nature Physics</i>, vol. 20, Springer Nature, 2024, pp. 310–21, doi:<a href=\"https://doi.org/10.1038/s41567-023-02302-1\">10.1038/s41567-023-02302-1</a>.","apa":"Caballero Mancebo, S., Shinde, R., Bolger-Munro, M., Peruzzo, M., Szep, G., Steccari, I., … Heisenberg, C.-P. J. (2024). Friction forces determine cytoplasmic reorganization and shape changes of ascidian oocytes upon fertilization. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-023-02302-1\">https://doi.org/10.1038/s41567-023-02302-1</a>","short":"S. Caballero Mancebo, R. Shinde, M. Bolger-Munro, M. Peruzzo, G. Szep, I. Steccari, D. Labrousse Arias, V. Zheden, J. Merrin, A. Callan-Jones, R. Voituriez, C.-P.J. Heisenberg, Nature Physics 20 (2024) 310–321.","ieee":"S. Caballero Mancebo <i>et al.</i>, “Friction forces determine cytoplasmic reorganization and shape changes of ascidian oocytes upon fertilization,” <i>Nature Physics</i>, vol. 20. Springer Nature, pp. 310–321, 2024.","chicago":"Caballero Mancebo, Silvia, Rushikesh Shinde, Madison Bolger-Munro, Matilda Peruzzo, Gregory Szep, Irene Steccari, David Labrousse Arias, et al. “Friction Forces Determine Cytoplasmic Reorganization and Shape Changes of Ascidian Oocytes upon Fertilization.” <i>Nature Physics</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41567-023-02302-1\">https://doi.org/10.1038/s41567-023-02302-1</a>.","ama":"Caballero Mancebo S, Shinde R, Bolger-Munro M, et al. Friction forces determine cytoplasmic reorganization and shape changes of ascidian oocytes upon fertilization. <i>Nature Physics</i>. 2024;20:310-321. doi:<a href=\"https://doi.org/10.1038/s41567-023-02302-1\">10.1038/s41567-023-02302-1</a>","ista":"Caballero Mancebo S, Shinde R, Bolger-Munro M, Peruzzo M, Szep G, Steccari I, Labrousse Arias D, Zheden V, Merrin J, Callan-Jones A, Voituriez R, Heisenberg C-PJ. 2024. Friction forces determine cytoplasmic reorganization and shape changes of ascidian oocytes upon fertilization. Nature Physics. 20, 310–321."},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"date_published":"2024-02-01T00:00:00Z","doi":"10.1038/s41567-023-02302-1","isi":1,"dataavailabilitystatement":"Source data are provided with this paper. All other data supporting the findings of this study are available from the corresponding author on request","status":"public","project":[{"name":"Control of embryonic cleavage pattern","grant_number":"I03601","_id":"2646861A-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"abstract":[{"lang":"eng","text":"Contraction and flow of the actin cell cortex have emerged as a common principle by which cells reorganize their cytoplasm and take shape. However, how these cortical flows interact with adjacent cytoplasmic components, changing their form and localization, and how this affects cytoplasmic organization and cell shape remains unclear. Here we show that in ascidian oocytes, the cooperative activities of cortical actomyosin flows and deformation of the adjacent mitochondria-rich myoplasm drive oocyte cytoplasmic reorganization and shape changes following fertilization. We show that vegetal-directed cortical actomyosin flows, established upon oocyte fertilization, lead to both the accumulation of cortical actin at the vegetal pole of the zygote and compression and local buckling of the adjacent elastic solid-like myoplasm layer due to friction forces generated at their interface. Once cortical flows have ceased, the multiple myoplasm buckles resolve into one larger buckle, which again drives the formation of the contraction pole—a protuberance of the zygote’s vegetal pole where maternal mRNAs accumulate. Thus, our findings reveal a mechanism where cortical actomyosin network flows determine cytoplasmic reorganization and cell shape by deforming adjacent cytoplasmic components through friction forces."}],"related_material":{"link":[{"relation":"press_release","url":"https://ista.ac.at/en/news/stranger-than-friction-a-force-initiating-life/","description":"News on ISTA Website"}]},"month":"02","type":"journal_article","external_id":{"isi":["001138880800005"],"pmid":["38370025"]},"oa_version":"Published Version","das_tickbox":"1"},{"intvolume":"        20","corr_author":"1","language":[{"iso":"eng"}],"year":"2024","day":"01","publication":"Nature Physics","volume":20,"article_type":"letter_note","author":[{"last_name":"Baykusheva","id":"71b4d059-2a03-11ee-914d-dfa3beed6530","full_name":"Baykusheva, Denitsa Rangelova","orcid":"0000-0002-7438-1139","first_name":"Denitsa Rangelova"}],"title":"Through the slopes of a light-induced phase transition","quality_controlled":"1","scopus_import":"1","publication_identifier":{"issn":["1745-2473"],"eissn":["1745-2481"]},"publisher":"Springer Nature","supplementarymaterial":"no","date_created":"2025-01-27T14:29:20Z","_id":"18919","page":"684-685","department":[{"_id":"DeBa"}],"article_processing_charge":"No","publication_status":"published","issue":"5","date_updated":"2026-10-01T09:37:00Z","fulldoi":"https://doi.org/10.1038/s41567-024-02401-7","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","researchdata_availability":"no","type":"journal_article","external_id":{"isi":["001162208200002"]},"das_tickbox":"0","oa_version":"None","abstract":[{"lang":"eng","text":"The integration of theory and experiment makes possible tracking the slow evolution of a photodoped Mott insulator to a distinct non-equilibrium metallic phase under the influence of electron-lattice coupling."}],"month":"05","doi":"10.1038/s41567-024-02401-7","OA_type":"closed access","isi":1,"status":"public","citation":{"apa":"Baykusheva, D. R. (2024). Through the slopes of a light-induced phase transition. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-024-02401-7\">https://doi.org/10.1038/s41567-024-02401-7</a>","mla":"Baykusheva, Denitsa Rangelova. “Through the Slopes of a Light-Induced Phase Transition.” <i>Nature Physics</i>, vol. 20, no. 5, Springer Nature, 2024, pp. 684–85, doi:<a href=\"https://doi.org/10.1038/s41567-024-02401-7\">10.1038/s41567-024-02401-7</a>.","ieee":"D. R. Baykusheva, “Through the slopes of a light-induced phase transition,” <i>Nature Physics</i>, vol. 20, no. 5. Springer Nature, pp. 684–685, 2024.","short":"D.R. Baykusheva, Nature Physics 20 (2024) 684–685.","ama":"Baykusheva DR. Through the slopes of a light-induced phase transition. <i>Nature Physics</i>. 2024;20(5):684-685. doi:<a href=\"https://doi.org/10.1038/s41567-024-02401-7\">10.1038/s41567-024-02401-7</a>","chicago":"Baykusheva, Denitsa Rangelova. “Through the Slopes of a Light-Induced Phase Transition.” <i>Nature Physics</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41567-024-02401-7\">https://doi.org/10.1038/s41567-024-02401-7</a>.","ista":"Baykusheva DR. 2024. Through the slopes of a light-induced phase transition. Nature Physics. 20(5), 684–685."},"date_published":"2024-05-01T00:00:00Z"},{"project":[{"call_identifier":"H2020","_id":"05943252-7A3F-11EA-A408-12923DDC885E","grant_number":"851288","name":"Design Principles of Branching Morphogenesis"},{"_id":"34e2a5b5-11ca-11ed-8bc3-b2265616ef0b","name":"A mechano-chemical theory for stem cell fate decisions in organoid development","grant_number":"ALTF 343-2022"}],"status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2022.07.17.500364"}],"doi":"10.1038/s41567-024-02532-x","isi":1,"OA_type":"green","dataavailabilitystatement":"All data are available from the corresponding authors upon request. Source data are provided with this paper.","date_published":"2024-09-01T00:00:00Z","citation":{"apa":"Vercruysse, E., Brückner, D., Gómez-González, M., Remson, A., Luciano, M., Kalukula, Y., … Gabriele, S. (2024). Geometry-driven migration efficiency of autonomous epithelial cell clusters. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-024-02532-x\">https://doi.org/10.1038/s41567-024-02532-x</a>","mla":"Vercruysse, Eléonore, et al. “Geometry-Driven Migration Efficiency of Autonomous Epithelial Cell Clusters.” <i>Nature Physics</i>, vol. 20, Springer Nature, 2024, pp. 1492–500, doi:<a href=\"https://doi.org/10.1038/s41567-024-02532-x\">10.1038/s41567-024-02532-x</a>.","ista":"Vercruysse E, Brückner D, Gómez-González M, Remson A, Luciano M, Kalukula Y, Rossetti L, Trepat X, Hannezo EB, Gabriele S. 2024. Geometry-driven migration efficiency of autonomous epithelial cell clusters. Nature Physics. 20, 1492–1500.","ama":"Vercruysse E, Brückner D, Gómez-González M, et al. Geometry-driven migration efficiency of autonomous epithelial cell clusters. <i>Nature Physics</i>. 2024;20:1492-1500. doi:<a href=\"https://doi.org/10.1038/s41567-024-02532-x\">10.1038/s41567-024-02532-x</a>","chicago":"Vercruysse, Eléonore, David Brückner, Manuel Gómez-González, Alexandre Remson, Marine Luciano, Yohalie Kalukula, Leone Rossetti, Xavier Trepat, Edouard B Hannezo, and Sylvain Gabriele. “Geometry-Driven Migration Efficiency of Autonomous Epithelial Cell Clusters.” <i>Nature Physics</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41567-024-02532-x\">https://doi.org/10.1038/s41567-024-02532-x</a>.","ieee":"E. Vercruysse <i>et al.</i>, “Geometry-driven migration efficiency of autonomous epithelial cell clusters,” <i>Nature Physics</i>, vol. 20. Springer Nature, pp. 1492–1500, 2024.","short":"E. Vercruysse, D. Brückner, M. Gómez-González, A. Remson, M. Luciano, Y. Kalukula, L. Rossetti, X. Trepat, E.B. Hannezo, S. Gabriele, Nature Physics 20 (2024) 1492–1500."},"oa_version":"Preprint","das_tickbox":"1","external_id":{"isi":["001250246200004"]},"type":"journal_article","month":"09","abstract":[{"lang":"eng","text":"The directed migration of epithelial cell collectives through coordinated movements plays a crucial role in various physiological processes and is increasingly understood at the level of large confluent monolayers. However, numerous processes rely on the migration of small groups of polarized epithelial clusters in complex environments, and their responses to external geometries remain poorly understood. To address this, we cultivate primary epithelial keratocyte tissues on adhesive microstripes to create autonomous epithelial clusters with well-defined geometries. We show that their migration efficiency is strongly influenced by the contact geometry and the orientation of cell–cell contacts with respect to the direction of migration. A combination of velocity and polarity alignment with contact regulation of locomotion in an active matter model captures quantitatively the experimental data. Furthermore, we predict that this combination of rules enables efficient navigation in complex geometries, which we confirm experimentally. Altogether, our findings provide a conceptual framework for extracting the interaction rules of active systems from their interaction with physical boundaries, as well as design principles for collective navigation in complex microenvironments."}],"related_material":{"link":[{"description":"News on ISTA website","url":"https://ista.ac.at/en/news/a-railroad-of-cells/","relation":"press_release"}]},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","ec_funded":1,"researchdata_availability":"yes","publication_status":"published","fulldoi":"https://doi.org/10.1038/s41567-024-02532-x","date_updated":"2026-10-01T11:02:43Z","article_processing_charge":"No","department":[{"_id":"EdHa"}],"supplementarymaterial":"yes","_id":"17269","page":"1492-1500","date_created":"2024-07-16T12:32:17Z","title":"Geometry-driven migration efficiency of autonomous epithelial cell clusters","quality_controlled":"1","author":[{"first_name":"Eléonore","last_name":"Vercruysse","full_name":"Vercruysse, Eléonore"},{"first_name":"David","orcid":"0000-0001-7205-2975","id":"e1e86031-6537-11eb-953a-f7ab92be508d","last_name":"Brückner","full_name":"Brückner, David"},{"first_name":"Manuel","full_name":"Gómez-González, Manuel","last_name":"Gómez-González"},{"first_name":"Alexandre","full_name":"Remson, Alexandre","last_name":"Remson"},{"first_name":"Marine","full_name":"Luciano, Marine","last_name":"Luciano"},{"last_name":"Kalukula","full_name":"Kalukula, Yohalie","first_name":"Yohalie"},{"first_name":"Leone","last_name":"Rossetti","full_name":"Rossetti, Leone"},{"last_name":"Trepat","full_name":"Trepat, Xavier","first_name":"Xavier"},{"id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","full_name":"Hannezo, Edouard B","last_name":"Hannezo","first_name":"Edouard B","orcid":"0000-0001-6005-1561"},{"last_name":"Gabriele","full_name":"Gabriele, Sylvain","first_name":"Sylvain"}],"article_type":"original","publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"publisher":"Springer Nature","scopus_import":"1","acknowledgement":"M.L., E.V. and S.G. acknowledge funding from the European Regional Development Fund (ERDF) Prostem Research Project (No. 1510614, Wallonia DG06), the Epiforce Project of the National Fund for Scientific Research, Belgium (FRS-FNRS; Project No. T.0092.21), the Cellsqueezer Project of FRS-FNRS (Project No. J.0061.23), the Optopattern Project of FRS-FNRS (Project no. U.NO26.22) and the Interreg MAT(T)ISSE project, which is financially supported by Interreg France-Wallonie-Vlaanderen, ERDF). A.R. and M.L. are financially supported by FRS-FNRS as a research fellow (Aspirant FNRS) and Postdoctoral Researcher (Chargée de Recherches FNRS), respectively. E.V. and Y.K. are financially supported by FRS-FNRS through grants from the Fund for Research Training in Industry and Agriculture (FRIA). This project was supported by the European Research Council under the European Union’s Horizon 2020 Research and Innovation Programme (Grant Agreement No. 851288 to E.H.) and Marie Skłodowska-Curie Actions (Grant Agreement No. 797621 to M.G.-G.). D.B.B. was supported by the NOMIS foundation as a NOMIS fellow and by the European Molecular Biology Organization (Postdoctoral Fellowship ALTF 343-2022) and performed this work in part at the Aspen Center for Physics, which is supported by the National Science Foundation (Grant No. PHY-1607611). X.T. and M.G.-G. acknowledge support from the Government of Catalonia (Grant No. AGAUR SGR-2017-01602 and a CERCA Programme), the Spanish Ministry for Science and Innovation and ERDF (Grant No. PGC2018-099645-B-I00), the European Research Council (Grant No. Adv-883739), Fundació la Marató de TV3 (201903-30-31-32), the European Commission (Grant No. H2020-FETPROACT-01-2016-731957), La Caixa Foundation and the Biomedical Research Center Consortium in Red (Grant No. CB15/00153) at the Carlos III Health Institute, Ministry of Science and Innovation. IBEC is recipient of a Severo Ochoa Award of Excellence from the Spanish Ministry of Economy, Trade and Business.","day":"01","publication":"Nature Physics","volume":20,"oa":1,"intvolume":"        20","year":"2024","OA_place":"repository","corr_author":"1","language":[{"iso":"eng"}]},{"date_updated":"2025-04-14T07:43:56Z","fulldoi":"https://doi.org/10.1038/s41567-023-02136-x","publication_status":"published","ec_funded":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"EdHa"},{"_id":"AnSa"},{"_id":"JePa"}],"has_accepted_license":"1","article_processing_charge":"Yes","ddc":["530"],"citation":{"ista":"Grober D, Palaia I, Ucar MC, Hannezo EB, Šarić A, Palacci JA. 2023. Unconventional colloidal aggregation in chiral bacterial baths. Nature Physics. 19, 1680–1688.","ama":"Grober D, Palaia I, Ucar MC, Hannezo EB, Šarić A, Palacci JA. Unconventional colloidal aggregation in chiral bacterial baths. <i>Nature Physics</i>. 2023;19:1680-1688. doi:<a href=\"https://doi.org/10.1038/s41567-023-02136-x\">10.1038/s41567-023-02136-x</a>","chicago":"Grober, Daniel, Ivan Palaia, Mehmet C Ucar, Edouard B Hannezo, Anđela Šarić, and Jérémie A Palacci. “Unconventional Colloidal Aggregation in Chiral Bacterial Baths.” <i>Nature Physics</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41567-023-02136-x\">https://doi.org/10.1038/s41567-023-02136-x</a>.","short":"D. Grober, I. Palaia, M.C. Ucar, E.B. Hannezo, A. Šarić, J.A. Palacci, Nature Physics 19 (2023) 1680–1688.","ieee":"D. Grober, I. Palaia, M. C. Ucar, E. B. Hannezo, A. Šarić, and J. A. Palacci, “Unconventional colloidal aggregation in chiral bacterial baths,” <i>Nature Physics</i>, vol. 19. Springer Nature, pp. 1680–1688, 2023.","mla":"Grober, Daniel, et al. “Unconventional Colloidal Aggregation in Chiral Bacterial Baths.” <i>Nature Physics</i>, vol. 19, Springer Nature, 2023, pp. 1680–88, doi:<a href=\"https://doi.org/10.1038/s41567-023-02136-x\">10.1038/s41567-023-02136-x</a>.","apa":"Grober, D., Palaia, I., Ucar, M. C., Hannezo, E. B., Šarić, A., &#38; Palacci, J. A. (2023). Unconventional colloidal aggregation in chiral bacterial baths. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-023-02136-x\">https://doi.org/10.1038/s41567-023-02136-x</a>"},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"date_published":"2023-11-01T00:00:00Z","doi":"10.1038/s41567-023-02136-x","isi":1,"status":"public","project":[{"grant_number":"101034413","name":"IST-BRIDGE: International postdoctoral program","call_identifier":"H2020","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c"},{"_id":"eba2549b-77a9-11ec-83b8-a81e493eae4e","call_identifier":"H2020","grant_number":"802960","name":"Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines"},{"name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"abstract":[{"text":"When in equilibrium, thermal forces agitate molecules, which then diffuse, collide and bind to form materials. However, the space of accessible structures in which micron-scale particles can be organized by thermal forces is limited, owing to the slow dynamics and metastable states. Active agents in a passive fluid generate forces and flows, forming a bath with active fluctuations. Two unanswered questions are whether those active agents can drive the assembly of passive components into unconventional states and which material properties they will exhibit. Here we show that passive, sticky beads immersed in a bath of swimming Escherichia coli bacteria aggregate into unconventional clusters and gels that are controlled by the activity of the bath. We observe a slow but persistent rotation of the aggregates that originates in the chirality of the E. coli flagella and directs aggregation into structures that are not accessible thermally. We elucidate the aggregation mechanism with a numerical model of spinning, sticky beads and reproduce quantitatively the experimental results. We show that internal activity controls the phase diagram and the structure of the aggregates. Overall, our results highlight the promising role of active baths in designing the structural and mechanical properties of materials with unconventional phases.","lang":"eng"}],"month":"11","external_id":{"isi":["001037346400005"]},"type":"journal_article","oa_version":"Published Version","publication":"Nature Physics","volume":19,"day":"01","acknowledgement":"D.G. and J.P. thank E. Krasnopeeva, C. Guet, G. Guessous and T. Hwa for providing the E. coli strains. This material is based upon work supported by the US Department of Energy under award DE-SC0019769. I.P. acknowledges funding by the European Union’s Horizon 2020 research and innovation programme under Marie Skłodowska-Curie Grant Agreement No. 101034413. A.Š. acknowledges funding from the European Research Council under the European Union’s Horizon 2020 research and innovation programme (Grant No. 802960). M.C.U. acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under Marie Skłodowska-Curie Grant Agreement No. 754411.","language":[{"iso":"eng"}],"corr_author":"1","year":"2023","intvolume":"        19","oa":1,"page":"1680-1688","_id":"13971","date_created":"2023-08-06T22:01:11Z","file_date_updated":"2024-01-30T12:26:08Z","scopus_import":"1","file":[{"success":1,"checksum":"7e282c2ebc0ac82125a04f6b4742d4c1","file_id":"14906","access_level":"open_access","relation":"main_file","creator":"dernst","content_type":"application/pdf","date_updated":"2024-01-30T12:26:08Z","date_created":"2024-01-30T12:26:08Z","file_name":"2023_NaturePhysics_Grober.pdf","file_size":6365607}],"publisher":"Springer Nature","publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"author":[{"first_name":"Daniel","last_name":"Grober","full_name":"Grober, Daniel","id":"abdfc56f-34fb-11ee-bd33-fd766fce5a99"},{"last_name":"Palaia","full_name":"Palaia, Ivan","id":"9c805cd2-4b75-11ec-a374-db6dd0ed57fa","orcid":" 0000-0002-8843-9485 ","first_name":"Ivan"},{"orcid":"0000-0003-0506-4217","first_name":"Mehmet C","last_name":"Ucar","id":"50B2A802-6007-11E9-A42B-EB23E6697425","full_name":"Ucar, Mehmet C"},{"orcid":"0000-0001-6005-1561","first_name":"Edouard B","full_name":"Hannezo, Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","last_name":"Hannezo"},{"orcid":"0000-0002-7854-2139","first_name":"Anđela","full_name":"Šarić, Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","last_name":"Šarić"},{"first_name":"Jérémie A","orcid":"0000-0002-7253-9465","last_name":"Palacci","id":"8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d","full_name":"Palacci, Jérémie A"}],"article_type":"original","quality_controlled":"1","title":"Unconventional colloidal aggregation in chiral bacterial baths"},{"status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2012.15270"}],"doi":"10.1038/s41567-022-01887-3","date_published":"2023-01-26T00:00:00Z","citation":{"mla":"Leonard, Julian, et al. “Probing the Onset of Quantum Avalanches in a Many-Body Localized System.” <i>Nature Physics</i>, vol. 19, no. 4, Springer Nature, 2023, pp. 481–85, doi:<a href=\"https://doi.org/10.1038/s41567-022-01887-3\">10.1038/s41567-022-01887-3</a>.","apa":"Leonard, J., Kim, S., Rispoli, M., Lukin, A., Schittko, R., Kwan, J., … Greiner, M. (2023). Probing the onset of quantum avalanches in a many-body localized system. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-022-01887-3\">https://doi.org/10.1038/s41567-022-01887-3</a>","short":"J. Leonard, S. Kim, M. Rispoli, A. Lukin, R. Schittko, J. Kwan, E. Demler, D. Sels, M. Greiner, Nature Physics 19 (2023) 481–485.","ieee":"J. Leonard <i>et al.</i>, “Probing the onset of quantum avalanches in a many-body localized system,” <i>Nature Physics</i>, vol. 19, no. 4. Springer Nature, pp. 481–485, 2023.","ista":"Leonard J, Kim S, Rispoli M, Lukin A, Schittko R, Kwan J, Demler E, Sels D, Greiner M. 2023. Probing the onset of quantum avalanches in a many-body localized system. Nature Physics. 19(4), 481–485.","ama":"Leonard J, Kim S, Rispoli M, et al. Probing the onset of quantum avalanches in a many-body localized system. <i>Nature Physics</i>. 2023;19(4):481-485. doi:<a href=\"https://doi.org/10.1038/s41567-022-01887-3\">10.1038/s41567-022-01887-3</a>","chicago":"Leonard, Julian, Sooshin Kim, Matthew Rispoli, Alexander Lukin, Robert Schittko, Joyce Kwan, Eugene Demler, Dries Sels, and Markus Greiner. “Probing the Onset of Quantum Avalanches in a Many-Body Localized System.” <i>Nature Physics</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41567-022-01887-3\">https://doi.org/10.1038/s41567-022-01887-3</a>."},"oa_version":"Preprint","type":"journal_article","external_id":{"arxiv":["2012.15270"]},"month":"01","abstract":[{"text":"Strongly correlated systems can exhibit unexpected phenomena when brought in a state far from equilibrium. An example is many-body localization, which prevents generic interacting systems from reaching thermal equilibrium even at long times1,2. The stability of the many-body localized phase has been predicted to be hindered by the presence of small thermal inclusions that act as a bath, leading to the delocalization of the entire system through an avalanche propagation mechanism3,4,5,6,7,8. Here we study the dynamics of a thermal inclusion of variable size when it is coupled to a many-body localized system. We find evidence for accelerated transport of thermal inclusion into the localized region. We monitor how the avalanche spreads through the localized system and thermalizes it site by site by measuring the site-resolved entropy over time. Furthermore, we isolate the strongly correlated bath-induced dynamics with multipoint correlations between the bath and the system. Our results have implications on the robustness of many-body localized systems and their critical behaviour.","lang":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"4","publication_status":"published","fulldoi":"https://doi.org/10.1038/s41567-022-01887-3","date_updated":"2024-10-08T10:52:08Z","article_processing_charge":"No","extern":"1","date_created":"2024-10-07T11:46:33Z","_id":"18190","page":"481-485","title":"Probing the onset of quantum avalanches in a many-body localized system","quality_controlled":"1","article_type":"letter_note","author":[{"last_name":"Leonard","id":"b75b3f45-7995-11ef-9bfd-9a9cd02c3577","full_name":"Leonard, Julian","first_name":"Julian"},{"first_name":"Sooshin","last_name":"Kim","full_name":"Kim, Sooshin"},{"first_name":"Matthew","last_name":"Rispoli","full_name":"Rispoli, Matthew"},{"last_name":"Lukin","full_name":"Lukin, Alexander","first_name":"Alexander"},{"full_name":"Schittko, Robert","last_name":"Schittko","first_name":"Robert"},{"first_name":"Joyce","last_name":"Kwan","full_name":"Kwan, Joyce"},{"last_name":"Demler","full_name":"Demler, Eugene","first_name":"Eugene"},{"first_name":"Dries","last_name":"Sels","full_name":"Sels, Dries"},{"first_name":"Markus","full_name":"Greiner, Markus","last_name":"Greiner"}],"publication_identifier":{"issn":["1745-2473"],"eissn":["1745-2481"]},"publisher":"Springer Nature","scopus_import":"1","day":"26","arxiv":1,"publication":"Nature Physics","volume":19,"oa":1,"intvolume":"        19","year":"2023","language":[{"iso":"eng"}]},{"department":[{"_id":"BiCh"}],"article_processing_charge":"No","fulldoi":"https://doi.org/10.1038/s41567-023-02074-8","date_updated":"2026-08-07T11:34:35Z","publication_status":"published","researchdata_availability":"yes","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","type":"journal_article","external_id":{"isi":["000996921200001"]},"oa_version":"None","das_tickbox":"1","abstract":[{"lang":"eng","text":"Under high pressures and temperatures, molecular systems with substantial polarization charges, such as ammonia and water, are predicted to form superionic phases and dense fluid states with dissociating molecules and high electrical conductivity. This behaviour potentially plays a role in explaining the origin of the multipolar magnetic fields of Uranus and Neptune, whose mantles are thought to result from a mixture of H2O, NH3 and CH4 ices. Determining the stability domain, melting curve and electrical conductivity of these superionic phases is therefore crucial for modelling planetary interiors and dynamos. Here we report the melting curve of superionic ammonia up to 300 GPa from laser-driven shock compression of pre-compressed samples and atomistic calculations. We show that ammonia melts at lower temperatures than water above 100 GPa and that fluid ammonia’s electrical conductivity exceeds that of water at conditions predicted by hot, super-adiabatic models for Uranus and Neptune, and enhances the conductivity in their fluid water-rich dynamo layers."}],"related_material":{"link":[{"relation":"erratum","url":"https://doi.org/10.1038/s41567-023-02130-3"}]},"month":"09","isi":1,"dataavailabilitystatement":"Data supporting this study are available in the Supplementary Information, from the online repository (ref 66) and from the corresponding author upon request.\r\n66. Hernandez, J.-A. Melting curve of superionic ammonia at planetary interior conditions. OSF https://doi.org/10.17605/OSF.IO/DETZM (2023).","doi":"10.1038/s41567-023-02074-8","status":"public","citation":{"mla":"Hernandez, J. A., et al. “Melting Curve of Superionic Ammonia at Planetary Interior Conditions.” <i>Nature Physics</i>, vol. 19, Springer Nature, 2023, pp. 1280–85, doi:<a href=\"https://doi.org/10.1038/s41567-023-02074-8\">10.1038/s41567-023-02074-8</a>.","apa":"Hernandez, J.-A., Bethkenhagen, M., Ninet, S., French, M., Benuzzi-Mounaix, A., Datchi, F., … Ravasio, A. (2023). Melting curve of superionic ammonia at planetary interior conditions. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-023-02074-8\">https://doi.org/10.1038/s41567-023-02074-8</a>","ieee":"J.-A. Hernandez <i>et al.</i>, “Melting curve of superionic ammonia at planetary interior conditions,” <i>Nature Physics</i>, vol. 19. Springer Nature, pp. 1280–1285, 2023.","short":"J.-A. Hernandez, M. Bethkenhagen, S. Ninet, M. French, A. Benuzzi-Mounaix, F. Datchi, M. Guarguaglini, F. Lefevre, F. Occelli, R. Redmer, T. Vinci, A. Ravasio, Nature Physics 19 (2023) 1280–1285.","ama":"Hernandez J-A, Bethkenhagen M, Ninet S, et al. Melting curve of superionic ammonia at planetary interior conditions. <i>Nature Physics</i>. 2023;19:1280-1285. doi:<a href=\"https://doi.org/10.1038/s41567-023-02074-8\">10.1038/s41567-023-02074-8</a>","chicago":"Hernandez, J.-A., Mandy Bethkenhagen, S. Ninet, M. French, A. Benuzzi-Mounaix, F. Datchi, M. Guarguaglini, et al. “Melting Curve of Superionic Ammonia at Planetary Interior Conditions.” <i>Nature Physics</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41567-023-02074-8\">https://doi.org/10.1038/s41567-023-02074-8</a>.","ista":"Hernandez J-A, Bethkenhagen M, Ninet S, French M, Benuzzi-Mounaix A, Datchi F, Guarguaglini M, Lefevre F, Occelli F, Redmer R, Vinci T, Ravasio A. 2023. Melting curve of superionic ammonia at planetary interior conditions. Nature Physics. 19, 1280–1285."},"date_published":"2023-09-01T00:00:00Z","intvolume":"        19","language":[{"iso":"eng"}],"year":"2023","day":"01","acknowledgement":"We acknowledge the crucial contribution of the LULI2000 laser and support teams to the success of the experiments. We also thank S. Brygoo and P. Loubeyre for useful discussions. This research was supported by the French National Research Agency (ANR) through the projects POMPEI (grant no. ANR-16-CE31-0008) and SUPER-ICES (grant ANR-15-CE30-008-01), and by the PLAS@PAR Federation. M.F. and R.R. gratefully acknowledge support by the DFG within the Research Unit FOR 2440. M.B. was supported by the European Union within the Marie Skłodowska-Curie actions (xICE grant 894725) and the NOMIS foundation. The DFT-MD calculations were performed at the North-German Supercomputing Alliance facilities.","publication":"Nature Physics","volume":19,"article_type":"original","author":[{"last_name":"Hernandez","full_name":"Hernandez, J.-A.","first_name":"J.-A."},{"last_name":"Bethkenhagen","id":"201939f4-803f-11ed-ab7e-d8da4bd1517f","full_name":"Bethkenhagen, Mandy","orcid":"0000-0002-1838-2129","first_name":"Mandy"},{"first_name":"S.","last_name":"Ninet","full_name":"Ninet, S."},{"first_name":"M.","full_name":"French, M.","last_name":"French"},{"last_name":"Benuzzi-Mounaix","full_name":"Benuzzi-Mounaix, A.","first_name":"A."},{"first_name":"F.","full_name":"Datchi, F.","last_name":"Datchi"},{"first_name":"M.","full_name":"Guarguaglini, M.","last_name":"Guarguaglini"},{"first_name":"F.","last_name":"Lefevre","full_name":"Lefevre, F."},{"full_name":"Occelli, F.","last_name":"Occelli","first_name":"F."},{"first_name":"R.","last_name":"Redmer","full_name":"Redmer, R."},{"full_name":"Vinci, T.","last_name":"Vinci","first_name":"T."},{"last_name":"Ravasio","full_name":"Ravasio, A.","first_name":"A."}],"quality_controlled":"1","title":"Melting curve of superionic ammonia at planetary interior conditions","scopus_import":"1","publisher":"Springer Nature","publication_identifier":{"issn":["1745-2473"],"eissn":["1745-2481"]},"supplementarymaterial":"yes","date_created":"2023-06-04T22:01:02Z","_id":"13118","page":"1280-1285"}]