@article{21111,
  abstract     = {Inhibiting PLA2 activity should, in theory, be an effective approach to control the inflammation. Several naturally occurring polyphenolic compounds have been reported as inhibitors of PLA2. Among the naturally occurring polyphenols, catechol (1,2-dihydroxybenzene) possesses anti-inflammatory activity. Catechol can inhibit cyclooxygenase and lipo-oxygenase. By means of enzyme kinetic study, it was revealed that catechol can inhibit PLA2 also. Crystal structure showed that catechol binds to PLA2 at the opening of the active site cleft. This might stop the entry of substrate into the active site. Hence, catechol can be used as a lead compound for the development of novel anti-inflammatory drugs with PLA2 as the target.},
  author       = {Dileep, Kalarickal V. and Tintu, Ignatius and Mandal, Pradeep K and Karthe, Ponnuraj and Haridas, Madathilkovilakathu and Sadasivan, Chittalakkottu},
  issn         = {1747-0285},
  journal      = {Chemical Biology & Drug Design},
  number       = {1},
  pages        = {143--147},
  publisher    = {Wiley},
  title        = {{Binding to PLA2 may contribute to the anti‐inflammatory activity of catechol}},
  doi          = {10.1111/j.1747-0285.2011.01258.x},
  volume       = {79},
  year         = {2012},
}

@article{21112,
  abstract     = {<jats:p>Ester bond hydrolysis of membrane phospholipids by Phospholipase A2 and consequent release of fatty acids are the initiating steps of inflammation. It is proposed in this study that the inhibition of phospholipase A2 is one of the ways to control inflammation. Investigations are carried out to identify the mode of inhibition of phospholipase A2 by the n‐hexadecanoic acid. It may help in designing of specific inhibitors of phospholipase A2 as anti‐inflammatory agents. The enzyme kinetics study proved that n‐hexadecanoic acid inhibits phospholipase A2 in a competitive manner. It was identified from the crystal structure at 2.5Å resolution that the position of n‐hexadecanoic acid is in the active site of the phospholipase A2. The binding constant and binding energy have also been calculated using Isothermal Titration Calorimetry. Also, the binding energy of n‐hexadecanoic acid to phospholipase A2 was calculated by in silico method and compared with known inhibitors. It may be concluded from the structural and kinetics studies that the fatty acid, n‐hexadecanoic acid, is an inhibitor of phospholipase A2, hence, an anti‐inflammatory compound. The inferences from the present study validate the rigorous use of medicated oils rich in n‐hexadecanoic acid for the treatment of rheumatic symptoms in the traditional medical system of India, Ayurveda.},
  author       = {Aparna, Vasudevan and Dileep, Kalarickal V. and Mandal, Pradeep K and Karthe, Ponnuraj and Sadasivan, Chittalakkottu and Haridas, Madathilkovilakathu},
  issn         = {1747-0285},
  journal      = {Chemical Biology & Drug Design},
  number       = {3},
  pages        = {434--439},
  publisher    = {Wiley},
  title        = {{Anti-inflammatory property of n-hexadecanoic acid: Structural evidence and kinetic assessment}},
  doi          = {10.1111/j.1747-0285.2012.01418.x},
  volume       = {80},
  year         = {2012},
}