---
OA_type: closed access
_id: '20527'
abstract:
- lang: eng
text: "Arising from C. Yang et al. Nature Chemistry https://doi.org/10.1038/s41557-023-01212-2
(2023)\r\n\r\nIn this work Yang et al.1 claim that an enantioselective Michael
addition reaction with a barrier of 16 kcal mol−1 occurs at the single-molecule
level in frozen solvent by measuring fluctuations in current flowing across graphene-based
molecular devices. The article, however, contains major scientific errors that
undermine their conclusions. We highlight issues with the fabrication of the devices,
a lack of characterization, discrepancies between theory and experiment, unreliable
inelastic electron tunnelling spectra (IETS) and a perceived misinterpretation
of noise as evidence of reaction."
article_processing_charge: No
article_type: letter_note
author:
- first_name: Latha
full_name: Venkataraman, Latha
id: 9ebb78a5-cc0d-11ee-8322-fae086a32caf
last_name: Venkataraman
orcid: 0000-0002-6957-6089
- first_name: Jan
full_name: van Ruitenbeek, Jan
last_name: van Ruitenbeek
citation:
ama: Venkataraman L, van Ruitenbeek J. Questioning claims of monitoring the Michael
addition reaction at the single-molecule level. Nature Chemistry. 2024;16(11):1767-1769.
doi:10.1038/s41557-024-01631-9
apa: Venkataraman, L., & van Ruitenbeek, J. (2024). Questioning claims of monitoring
the Michael addition reaction at the single-molecule level. Nature Chemistry.
Springer Nature. https://doi.org/10.1038/s41557-024-01631-9
chicago: Venkataraman, Latha, and Jan van Ruitenbeek. “Questioning Claims of Monitoring
the Michael Addition Reaction at the Single-Molecule Level.” Nature Chemistry.
Springer Nature, 2024. https://doi.org/10.1038/s41557-024-01631-9.
ieee: L. Venkataraman and J. van Ruitenbeek, “Questioning claims of monitoring the
Michael addition reaction at the single-molecule level,” Nature Chemistry,
vol. 16, no. 11. Springer Nature, pp. 1767–1769, 2024.
ista: Venkataraman L, van Ruitenbeek J. 2024. Questioning claims of monitoring the
Michael addition reaction at the single-molecule level. Nature Chemistry. 16(11),
1767–1769.
mla: Venkataraman, Latha, and Jan van Ruitenbeek. “Questioning Claims of Monitoring
the Michael Addition Reaction at the Single-Molecule Level.” Nature Chemistry,
vol. 16, no. 11, Springer Nature, 2024, pp. 1767–69, doi:10.1038/s41557-024-01631-9.
short: L. Venkataraman, J. van Ruitenbeek, Nature Chemistry 16 (2024) 1767–1769.
date_created: 2025-10-23T12:16:57Z
date_published: 2024-11-01T00:00:00Z
date_updated: 2025-10-23T12:58:52Z
day: '01'
doi: 10.1038/s41557-024-01631-9
extern: '1'
external_id:
pmid:
- '39313629'
fulldoi: https://doi.org/10.1038/s41557-024-01631-9
intvolume: ' 16'
issue: '11'
language:
- iso: eng
month: '11'
oa_version: None
page: 1767-1769
pmid: 1
publication: Nature Chemistry
publication_identifier:
eissn:
- 1755-4349
issn:
- 1755-4330
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Questioning claims of monitoring the Michael addition reaction at the single-molecule
level
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2024'
...
---
OA_type: closed access
_id: '21819'
abstract:
- lang: eng
text: The ability of molecular photoswitches to convert on/off responses into large
macroscale property change is fundamental to light-responsive materials. However,
moving beyond simple binary responses necessitates the introduction of new elements
that control the chemistry of the photoswitching process at the molecular scale.
To achieve this goal, we designed, synthesized and developed a single photochrome,
based on a modified donor–acceptor Stenhouse adduct (DASA), capable of independently
addressing multiple molecular states. The multi-stage photoswitch enables complex
switching phenomena. To demonstrate this, we show spatial control of the transformation
of a three-stage photoswitch by tuning the population of intermediates along the
multi-step reaction pathway of the DASAs without interfering with either the first
or final stage. This allows for a photonic three-stage logic gate where the secondary
wavelength solely negates the input of the primary wavelength. These results provide
a new strategy to move beyond traditional on/off binary photochromic systems and
enable the design of future molecular logic systems.
article_processing_charge: No
article_type: original
author:
- first_name: Friedrich J
full_name: Stricker, Friedrich J
id: 7aca2cfc-46cf-11f0-abd3-8c96b5186745
last_name: Stricker
- first_name: David M.
full_name: Sanchez, David M.
last_name: Sanchez
- first_name: Umberto
full_name: Raucci, Umberto
last_name: Raucci
- first_name: Neil D.
full_name: Dolinski, Neil D.
last_name: Dolinski
- first_name: Manuel S.
full_name: Zayas, Manuel S.
last_name: Zayas
- first_name: Jan
full_name: Meisner, Jan
last_name: Meisner
- first_name: Craig. J.
full_name: Hawker, Craig. J.
last_name: Hawker
- first_name: Todd. J.
full_name: Martínez, Todd. J.
last_name: Martínez
- first_name: Javier
full_name: Read de Alaniz, Javier
last_name: Read de Alaniz
citation:
ama: Stricker FJ, Sanchez DM, Raucci U, et al. A multi-stage single photochrome
system for controlled photoswitching responses. Nature Chemistry. 2022;14:942-948.
doi:10.1038/s41557-022-00947-8
apa: Stricker, F. J., Sanchez, D. M., Raucci, U., Dolinski, N. D., Zayas, M. S.,
Meisner, J., … Read de Alaniz, J. (2022). A multi-stage single photochrome system
for controlled photoswitching responses. Nature Chemistry. Springer Nature.
https://doi.org/10.1038/s41557-022-00947-8
chicago: Stricker, Friedrich J, David M. Sanchez, Umberto Raucci, Neil D. Dolinski,
Manuel S. Zayas, Jan Meisner, Craig. J. Hawker, Todd. J. Martínez, and Javier
Read de Alaniz. “A Multi-Stage Single Photochrome System for Controlled Photoswitching
Responses.” Nature Chemistry. Springer Nature, 2022. https://doi.org/10.1038/s41557-022-00947-8.
ieee: F. J. Stricker et al., “A multi-stage single photochrome system for
controlled photoswitching responses,” Nature Chemistry, vol. 14. Springer
Nature, pp. 942–948, 2022.
ista: Stricker FJ, Sanchez DM, Raucci U, Dolinski ND, Zayas MS, Meisner J, Hawker
CJ, Martínez TJ, Read de Alaniz J. 2022. A multi-stage single photochrome system
for controlled photoswitching responses. Nature Chemistry. 14, 942–948.
mla: Stricker, Friedrich J., et al. “A Multi-Stage Single Photochrome System for
Controlled Photoswitching Responses.” Nature Chemistry, vol. 14, Springer
Nature, 2022, pp. 942–48, doi:10.1038/s41557-022-00947-8.
short: F.J. Stricker, D.M. Sanchez, U. Raucci, N.D. Dolinski, M.S. Zayas, J. Meisner,
C.J. Hawker, T.J. Martínez, J. Read de Alaniz, Nature Chemistry 14 (2022) 942–948.
date_created: 2026-05-06T10:56:14Z
date_published: 2022-06-09T00:00:00Z
date_updated: 2026-05-18T09:13:44Z
day: '09'
ddc:
- '540'
doi: 10.1038/s41557-022-00947-8
extern: '1'
external_id:
pmid:
- '35681046'
fulldoi: https://doi.org/10.1038/s41557-022-00947-8
intvolume: ' 14'
language:
- iso: eng
month: '06'
oa_version: None
page: 942-948
pmid: 1
publication: Nature Chemistry
publication_identifier:
eissn:
- 1755-4349
issn:
- 1755-4330
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: A multi-stage single photochrome system for controlled photoswitching responses
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2022'
...
---
OA_type: closed access
_id: '17871'
abstract:
- lang: eng
text: Single-molecule topological insulators are promising candidates as conducting
wires over nanometre length scales. A key advantage is their ability to exhibit
quasi-metallic transport, in contrast to conjugated molecular wires which typically
exhibit a low conductance that decays as the wire length increases. Here, we study
a family of oligophenylene-bridged bis(triarylamines) with tunable and stable
mono- or di-radicaloid character. These wires can undergo one- and two-electron
chemical oxidations to the corresponding mono-cation and di-cation, respectively.
We show that the oxidized wires exhibit reversed conductance decay with increasing
length, consistent with the expectation for Su–Schrieffer–Heeger-type one-dimensional
topological insulators. The 2.6-nm-long di-cation reported here displays a conductance
greater than 0.1G0, where G0 is the conductance quantum, a factor of 5,400 greater
than the neutral form. The observed conductance–length relationship is similar
between the mono-cation and di-cation series. Density functional theory calculations
elucidate how the frontier orbitals and delocalization of radicals facilitate
the observed non-classical quasi-metallic behaviour.
article_processing_charge: No
article_type: original
author:
- first_name: Liang
full_name: Li, Liang
last_name: Li
- first_name: Jonathan Z.
full_name: Low, Jonathan Z.
last_name: Low
- first_name: Jan
full_name: Wilhelm, Jan
last_name: Wilhelm
- first_name: Guanming
full_name: Liao, Guanming
last_name: Liao
- first_name: Suman
full_name: Gunasekaran, Suman
last_name: Gunasekaran
- first_name: Claudia R.
full_name: Prindle, Claudia R.
last_name: Prindle
- first_name: Rachel L.
full_name: Starr, Rachel L.
last_name: Starr
- first_name: Dorothea
full_name: Golze, Dorothea
last_name: Golze
- first_name: Colin
full_name: Nuckolls, Colin
last_name: Nuckolls
- first_name: Michael L.
full_name: Steigerwald, Michael L.
last_name: Steigerwald
- first_name: Ferdinand
full_name: Evers, Ferdinand
last_name: Evers
- first_name: Luis M.
full_name: Campos, Luis M.
last_name: Campos
- first_name: Xiaodong
full_name: Yin, Xiaodong
last_name: Yin
- first_name: Latha
full_name: Venkataraman, Latha
id: 9ebb78a5-cc0d-11ee-8322-fae086a32caf
last_name: Venkataraman
orcid: 0000-0002-6957-6089
citation:
ama: Li L, Low JZ, Wilhelm J, et al. Highly conducting single-molecule topological
insulators based on mono- and di-radical cations. Nature Chemistry. 2022;14(9):1061-1067.
doi:10.1038/s41557-022-00978-1
apa: Li, L., Low, J. Z., Wilhelm, J., Liao, G., Gunasekaran, S., Prindle, C. R.,
… Venkataraman, L. (2022). Highly conducting single-molecule topological insulators
based on mono- and di-radical cations. Nature Chemistry. Springer Nature.
https://doi.org/10.1038/s41557-022-00978-1
chicago: Li, Liang, Jonathan Z. Low, Jan Wilhelm, Guanming Liao, Suman Gunasekaran,
Claudia R. Prindle, Rachel L. Starr, et al. “Highly Conducting Single-Molecule
Topological Insulators Based on Mono- and Di-Radical Cations.” Nature Chemistry.
Springer Nature, 2022. https://doi.org/10.1038/s41557-022-00978-1.
ieee: L. Li et al., “Highly conducting single-molecule topological insulators
based on mono- and di-radical cations,” Nature Chemistry, vol. 14, no.
9. Springer Nature, pp. 1061–1067, 2022.
ista: Li L, Low JZ, Wilhelm J, Liao G, Gunasekaran S, Prindle CR, Starr RL, Golze
D, Nuckolls C, Steigerwald ML, Evers F, Campos LM, Yin X, Venkataraman L. 2022.
Highly conducting single-molecule topological insulators based on mono- and di-radical
cations. Nature Chemistry. 14(9), 1061–1067.
mla: Li, Liang, et al. “Highly Conducting Single-Molecule Topological Insulators
Based on Mono- and Di-Radical Cations.” Nature Chemistry, vol. 14, no.
9, Springer Nature, 2022, pp. 1061–67, doi:10.1038/s41557-022-00978-1.
short: L. Li, J.Z. Low, J. Wilhelm, G. Liao, S. Gunasekaran, C.R. Prindle, R.L.
Starr, D. Golze, C. Nuckolls, M.L. Steigerwald, F. Evers, L.M. Campos, X. Yin,
L. Venkataraman, Nature Chemistry 14 (2022) 1061–1067.
date_created: 2024-09-06T13:05:31Z
date_published: 2022-07-07T00:00:00Z
date_updated: 2024-12-10T09:37:45Z
day: '07'
doi: 10.1038/s41557-022-00978-1
extern: '1'
external_id:
pmid:
- '35798950'
fulldoi: https://doi.org/10.1038/s41557-022-00978-1
intvolume: ' 14'
issue: '9'
language:
- iso: eng
month: '07'
oa_version: None
page: 1061-1067
pmid: 1
publication: Nature Chemistry
publication_identifier:
eissn:
- 1755-4349
issn:
- 1755-4330
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Highly conducting single-molecule topological insulators based on mono- and
di-radical cations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2022'
...
---
_id: '13357'
abstract:
- lang: eng
text: Coulombic interactions can be used to assemble charged nanoparticles into
higher-order structures, but the process requires oppositely charged partners
that are similarly sized. The ability to mediate the assembly of such charged
nanoparticles using structurally simple small molecules would greatly facilitate
the fabrication of nanostructured materials and harnessing their applications
in catalysis, sensing and photonics. Here we show that small molecules with as
few as three electric charges can effectively induce attractive interactions between
oppositely charged nanoparticles in water. These interactions can guide the assembly
of charged nanoparticles into colloidal crystals of a quality previously only
thought to result from their co-crystallization with oppositely charged nanoparticles
of a similar size. Transient nanoparticle assemblies can be generated using positively
charged nanoparticles and multiply charged anions that are enzymatically hydrolysed
into mono- and/or dianions. Our findings demonstrate an approach for the facile
fabrication, manipulation and further investigation of static and dynamic nanostructured
materials in aqueous environments.
article_processing_charge: No
article_type: original
author:
- first_name: Tong
full_name: Bian, Tong
last_name: Bian
- first_name: Andrea
full_name: Gardin, Andrea
last_name: Gardin
- first_name: Julius
full_name: Gemen, Julius
last_name: Gemen
- first_name: Lothar
full_name: Houben, Lothar
last_name: Houben
- first_name: Claudio
full_name: Perego, Claudio
last_name: Perego
- first_name: Byeongdu
full_name: Lee, Byeongdu
last_name: Lee
- first_name: Nadav
full_name: Elad, Nadav
last_name: Elad
- first_name: Zonglin
full_name: Chu, Zonglin
last_name: Chu
- first_name: Giovanni M.
full_name: Pavan, Giovanni M.
last_name: Pavan
- first_name: Rafal
full_name: Klajn, Rafal
id: 8e84690e-1e48-11ed-a02b-a1e6fb8bb53b
last_name: Klajn
citation:
ama: Bian T, Gardin A, Gemen J, et al. Electrostatic co-assembly of nanoparticles
with oppositely charged small molecules into static and dynamic superstructures.
Nature Chemistry. 2021;13(10):940-949. doi:10.1038/s41557-021-00752-9
apa: Bian, T., Gardin, A., Gemen, J., Houben, L., Perego, C., Lee, B., … Klajn,
R. (2021). Electrostatic co-assembly of nanoparticles with oppositely charged
small molecules into static and dynamic superstructures. Nature Chemistry.
Springer Nature. https://doi.org/10.1038/s41557-021-00752-9
chicago: Bian, Tong, Andrea Gardin, Julius Gemen, Lothar Houben, Claudio Perego,
Byeongdu Lee, Nadav Elad, Zonglin Chu, Giovanni M. Pavan, and Rafal Klajn. “Electrostatic
Co-Assembly of Nanoparticles with Oppositely Charged Small Molecules into Static
and Dynamic Superstructures.” Nature Chemistry. Springer Nature, 2021.
https://doi.org/10.1038/s41557-021-00752-9.
ieee: T. Bian et al., “Electrostatic co-assembly of nanoparticles with oppositely
charged small molecules into static and dynamic superstructures,” Nature Chemistry,
vol. 13, no. 10. Springer Nature, pp. 940–949, 2021.
ista: Bian T, Gardin A, Gemen J, Houben L, Perego C, Lee B, Elad N, Chu Z, Pavan
GM, Klajn R. 2021. Electrostatic co-assembly of nanoparticles with oppositely
charged small molecules into static and dynamic superstructures. Nature Chemistry.
13(10), 940–949.
mla: Bian, Tong, et al. “Electrostatic Co-Assembly of Nanoparticles with Oppositely
Charged Small Molecules into Static and Dynamic Superstructures.” Nature Chemistry,
vol. 13, no. 10, Springer Nature, 2021, pp. 940–49, doi:10.1038/s41557-021-00752-9.
short: T. Bian, A. Gardin, J. Gemen, L. Houben, C. Perego, B. Lee, N. Elad, Z. Chu,
G.M. Pavan, R. Klajn, Nature Chemistry 13 (2021) 940–949.
date_created: 2023-08-01T09:34:54Z
date_published: 2021-10-01T00:00:00Z
date_updated: 2024-10-14T12:11:57Z
day: '01'
doi: 10.1038/s41557-021-00752-9
extern: '1'
external_id:
pmid:
- '34489564'
fulldoi: https://doi.org/10.1038/s41557-021-00752-9
intvolume: ' 13'
issue: '10'
keyword:
- General Chemical Engineering
- General Chemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41557-021-00752-9
month: '10'
oa: 1
oa_version: Published Version
page: 940-949
pmid: 1
publication: Nature Chemistry
publication_identifier:
eissn:
- 1755-4349
issn:
- 1755-4330
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Electrostatic co-assembly of nanoparticles with oppositely charged small molecules
into static and dynamic superstructures
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2021'
...
---
_id: '9250'
abstract:
- lang: eng
text: Aprotic alkali metal–O2 batteries face two major obstacles to their chemistry
occurring efficiently, the insulating nature of the formed alkali superoxides/peroxides
and parasitic reactions that are caused by the highly reactive singlet oxygen
(1O2). Redox mediators are recognized to be key for improving rechargeability.
However, it is unclear how they affect 1O2 formation, which hinders strategies
for their improvement. Here we clarify the mechanism of mediated peroxide and
superoxide oxidation and thus explain how redox mediators either enhance or suppress
1O2 formation. We show that charging commences with peroxide oxidation to a superoxide
intermediate and that redox potentials above ~3.5 V versus Li/Li+ drive 1O2 evolution
from superoxide oxidation, while disproportionation always generates some 1O2.
We find that 1O2 suppression requires oxidation to be faster than the generation
of 1O2 from disproportionation. Oxidation rates decrease with growing driving
force following Marcus inverted-region behaviour, establishing a region of maximum
rate.
acknowledged_ssus:
- _id: M-Shop
acknowledgement: S.A.F. is indebted to the European Research Council (ERC) under the
European Union’s Horizon 2020 research and innovation programme (grant agreement
No. 636069) as well as IST Austria. O.F thanks the French National Research Agency
(STORE-EX Labex Project ANR-10-LABX-76-01). We thank EL-Cell GmbH (Hamburg, Germany)
for the pressure test cell. We thank R. Saf for help with the mass spectrometry,
J. Schlegl for manufacturing instrumentation, M. Winkler of Acib GmbH, G. Strohmeier
and R. Fürst for HPLC measurements and S. Mondal and S. Stadlbauer for kinetic measurements.
article_processing_charge: No
article_type: original
author:
- first_name: Yann K.
full_name: Petit, Yann K.
last_name: Petit
- first_name: Eléonore
full_name: Mourad, Eléonore
last_name: Mourad
- first_name: Christian
full_name: Prehal, Christian
last_name: Prehal
- first_name: Christian
full_name: Leypold, Christian
last_name: Leypold
- first_name: Andreas
full_name: Windischbacher, Andreas
last_name: Windischbacher
- first_name: Daniel
full_name: Mijailovic, Daniel
last_name: Mijailovic
- first_name: Christian
full_name: Slugovc, Christian
last_name: Slugovc
- first_name: Sergey M.
full_name: Borisov, Sergey M.
last_name: Borisov
- first_name: Egbert
full_name: Zojer, Egbert
last_name: Zojer
- first_name: Sergio
full_name: Brutti, Sergio
last_name: Brutti
- first_name: Olivier
full_name: Fontaine, Olivier
last_name: Fontaine
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
citation:
ama: Petit YK, Mourad E, Prehal C, et al. Mechanism of mediated alkali peroxide
oxidation and triplet versus singlet oxygen formation. Nature Chemistry.
2021;13(5):465-471. doi:10.1038/s41557-021-00643-z
apa: Petit, Y. K., Mourad, E., Prehal, C., Leypold, C., Windischbacher, A., Mijailovic,
D., … Freunberger, S. A. (2021). Mechanism of mediated alkali peroxide oxidation
and triplet versus singlet oxygen formation. Nature Chemistry. Springer
Nature. https://doi.org/10.1038/s41557-021-00643-z
chicago: Petit, Yann K., Eléonore Mourad, Christian Prehal, Christian Leypold, Andreas
Windischbacher, Daniel Mijailovic, Christian Slugovc, et al. “Mechanism of Mediated
Alkali Peroxide Oxidation and Triplet versus Singlet Oxygen Formation.” Nature
Chemistry. Springer Nature, 2021. https://doi.org/10.1038/s41557-021-00643-z.
ieee: Y. K. Petit et al., “Mechanism of mediated alkali peroxide oxidation
and triplet versus singlet oxygen formation,” Nature Chemistry, vol. 13,
no. 5. Springer Nature, pp. 465–471, 2021.
ista: Petit YK, Mourad E, Prehal C, Leypold C, Windischbacher A, Mijailovic D, Slugovc
C, Borisov SM, Zojer E, Brutti S, Fontaine O, Freunberger SA. 2021. Mechanism
of mediated alkali peroxide oxidation and triplet versus singlet oxygen formation.
Nature Chemistry. 13(5), 465–471.
mla: Petit, Yann K., et al. “Mechanism of Mediated Alkali Peroxide Oxidation and
Triplet versus Singlet Oxygen Formation.” Nature Chemistry, vol. 13, no.
5, Springer Nature, 2021, pp. 465–71, doi:10.1038/s41557-021-00643-z.
short: Y.K. Petit, E. Mourad, C. Prehal, C. Leypold, A. Windischbacher, D. Mijailovic,
C. Slugovc, S.M. Borisov, E. Zojer, S. Brutti, O. Fontaine, S.A. Freunberger,
Nature Chemistry 13 (2021) 465–471.
corr_author: '1'
date_created: 2021-03-16T11:12:20Z
date_published: 2021-03-15T00:00:00Z
date_updated: 2024-10-09T21:00:28Z
day: '15'
ddc:
- '540'
department:
- _id: StFr
doi: 10.1038/s41557-021-00643-z
external_id:
isi:
- '000629296400001'
pmid:
- '33723377'
file:
- access_level: open_access
checksum: 3ee3f8dd79ed1b7bb0929fce184c8012
content_type: application/pdf
creator: dernst
date_created: 2021-03-22T11:46:00Z
date_updated: 2021-09-16T22:30:03Z
embargo: 2021-09-15
file_id: '9276'
file_name: 2021_NatureChem_Petit_acceptedVersion.pdf
file_size: 1811448
relation: main_file
file_date_updated: 2021-09-16T22:30:03Z
fulldoi: https://doi.org/10.1038/s41557-021-00643-z
has_accepted_license: '1'
intvolume: ' 13'
isi: 1
issue: '5'
keyword:
- General Chemistry
- General Chemical Engineering
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 465-471
pmid: 1
publication: Nature Chemistry
publication_identifier:
eissn:
- 1755-4349
issn:
- 1755-4330
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanism of mediated alkali peroxide oxidation and triplet versus singlet
oxygen formation
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 13
year: '2021'
...
---
OA_place: repository
OA_type: green
_id: '21084'
abstract:
- lang: eng
text: Self-assembly is a powerful method to obtain large discrete functional molecular
architectures. When using a single building block, self-assembly generally yields
symmetrical objects in which all the subunits relate similarly to their neighbours.
Here we report the discovery of a family of self-constructing cyclic macromolecules
with stable folded conformations of low symmetry, which include some with a prime
number (13, 17 and 23) of units, despite being formed from a single component.
The formation of these objects amounts to the production of polymers with a perfectly
uniform length. Design rules for the spontaneous emergence of such macromolecules
include endowing monomers with a strong potential for non-covalent interactions
that remain frustrated in competing entropically favoured yet conformationally
restrained smaller cycles. The process can also be templated by a guest molecule
that itself has an asymmetrical structure, which paves the way to molecular imprinting
techniques at the level of single polymer chains.
article_processing_charge: No
article_type: original
author:
- first_name: Charalampos G.
full_name: Pappas, Charalampos G.
last_name: Pappas
- first_name: Pradeep K
full_name: Mandal, Pradeep K
id: 6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
last_name: Mandal
orcid: 0000-0001-5996-956X
- first_name: Bin
full_name: Liu, Bin
last_name: Liu
- first_name: Brice
full_name: Kauffmann, Brice
last_name: Kauffmann
- first_name: Xiaoming
full_name: Miao, Xiaoming
last_name: Miao
- first_name: Dávid
full_name: Komáromy, Dávid
last_name: Komáromy
- first_name: Waldemar
full_name: Hoffmann, Waldemar
last_name: Hoffmann
- first_name: Christian
full_name: Manz, Christian
last_name: Manz
- first_name: Rayoon
full_name: Chang, Rayoon
last_name: Chang
- first_name: Kai
full_name: Liu, Kai
last_name: Liu
- first_name: Kevin
full_name: Pagel, Kevin
last_name: Pagel
- first_name: Ivan
full_name: Huc, Ivan
last_name: Huc
- first_name: Sijbren
full_name: Otto, Sijbren
last_name: Otto
citation:
ama: Pappas CG, Mandal PK, Liu B, et al. Emergence of low-symmetry foldamers from
single monomers. Nature Chemistry. 2020;12(12):1180-1186. doi:10.1038/s41557-020-00565-2
apa: Pappas, C. G., Mandal, P. K., Liu, B., Kauffmann, B., Miao, X., Komáromy, D.,
… Otto, S. (2020). Emergence of low-symmetry foldamers from single monomers. Nature
Chemistry. Springer Nature. https://doi.org/10.1038/s41557-020-00565-2
chicago: Pappas, Charalampos G., Pradeep K Mandal, Bin Liu, Brice Kauffmann, Xiaoming
Miao, Dávid Komáromy, Waldemar Hoffmann, et al. “Emergence of Low-Symmetry Foldamers
from Single Monomers.” Nature Chemistry. Springer Nature, 2020. https://doi.org/10.1038/s41557-020-00565-2.
ieee: C. G. Pappas et al., “Emergence of low-symmetry foldamers from single
monomers,” Nature Chemistry, vol. 12, no. 12. Springer Nature, pp. 1180–1186,
2020.
ista: Pappas CG, Mandal PK, Liu B, Kauffmann B, Miao X, Komáromy D, Hoffmann W,
Manz C, Chang R, Liu K, Pagel K, Huc I, Otto S. 2020. Emergence of low-symmetry
foldamers from single monomers. Nature Chemistry. 12(12), 1180–1186.
mla: Pappas, Charalampos G., et al. “Emergence of Low-Symmetry Foldamers from Single
Monomers.” Nature Chemistry, vol. 12, no. 12, Springer Nature, 2020, pp.
1180–86, doi:10.1038/s41557-020-00565-2.
short: C.G. Pappas, P.K. Mandal, B. Liu, B. Kauffmann, X. Miao, D. Komáromy, W.
Hoffmann, C. Manz, R. Chang, K. Liu, K. Pagel, I. Huc, S. Otto, Nature Chemistry
12 (2020) 1180–1186.
date_created: 2026-01-29T15:32:38Z
date_published: 2020-11-20T00:00:00Z
date_updated: 2026-02-23T11:46:11Z
day: '20'
doi: 10.1038/s41557-020-00565-2
extern: '1'
external_id:
pmid:
- '33219361 '
fulldoi: https://doi.org/10.1038/s41557-020-00565-2
has_accepted_license: '1'
intvolume: ' 12'
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.26434/chemrxiv.10079186
month: '11'
oa: 1
oa_version: Preprint
page: 1180-1186
pmid: 1
publication: Nature Chemistry
publication_identifier:
eissn:
- 1755-4349
issn:
- 1755-4330
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Emergence of low-symmetry foldamers from single monomers
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2020'
...
---
_id: '10351'
abstract:
- lang: eng
text: Oligomeric species populated during the aggregation of the Aβ42 peptide have
been identified as potent cytotoxins linked to Alzheimer’s disease, but the fundamental
molecular pathways that control their dynamics have yet to be elucidated. By developing
a general approach that combines theory, experiment and simulation, we reveal,
in molecular detail, the mechanisms of Aβ42 oligomer dynamics during amyloid fibril
formation. Even though all mature amyloid fibrils must originate as oligomers,
we found that most Aβ42 oligomers dissociate into their monomeric precursors without
forming new fibrils. Only a minority of oligomers converts into fibrillar structures.
Moreover, the heterogeneous ensemble of oligomeric species interconverts on timescales
comparable to those of aggregation. Our results identify fundamentally new steps
that could be targeted by therapeutic interventions designed to combat protein
misfolding diseases.
acknowledgement: We acknowledge support from Peterhouse (T.C.T.M.), the Swiss National
Science foundation (T.C.T.M.), the Royal Society (A.Š.), the Academy of Medical
Sciences (A.Š.), the UCL Institute for the Physics of Living Systems (S.C.), Sidney
Sussex College (G.M.), the Wellcome Trust (A.Š., M.V., C.M.D. and T.P.J.K.), the
Schiff Foundation (A.J.D.), the Cambridge Centre for Misfolding Diseases (M.V.,
C.M.D. and T.P.J.K.), the BBSRC (C.M.D. and T.P.J.K.), the Frances and Augustus
Newman Foundation (T.P.J.K.), the Swedish Research Council (S.L.) and the ERC grant
MAMBA (S.L., agreement no. 340890). The research that led to these results received
funding from the European Research Council under the European Union’s Seventh Framework
Programme (FP7/2007-2013) through the ERC grant PhysProt (agreement no. 337969).
article_processing_charge: No
article_type: original
author:
- first_name: Thomas C. T.
full_name: Michaels, Thomas C. T.
last_name: Michaels
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Samo
full_name: Curk, Samo
last_name: Curk
- first_name: Katja
full_name: Bernfur, Katja
last_name: Bernfur
- first_name: Paolo
full_name: Arosio, Paolo
last_name: Arosio
- first_name: Georg
full_name: Meisl, Georg
last_name: Meisl
- first_name: Alexander J.
full_name: Dear, Alexander J.
last_name: Dear
- first_name: Samuel I. A.
full_name: Cohen, Samuel I. A.
last_name: Cohen
- first_name: Christopher M.
full_name: Dobson, Christopher M.
last_name: Dobson
- first_name: Michele
full_name: Vendruscolo, Michele
last_name: Vendruscolo
- first_name: Sara
full_name: Linse, Sara
last_name: Linse
- first_name: Tuomas P. J.
full_name: Knowles, Tuomas P. J.
last_name: Knowles
citation:
ama: Michaels TCT, Šarić A, Curk S, et al. Dynamics of oligomer populations formed
during the aggregation of Alzheimer’s Aβ42 peptide. Nature Chemistry. 2020;12(5):445-451.
doi:10.1038/s41557-020-0452-1
apa: Michaels, T. C. T., Šarić, A., Curk, S., Bernfur, K., Arosio, P., Meisl, G.,
… Knowles, T. P. J. (2020). Dynamics of oligomer populations formed during the
aggregation of Alzheimer’s Aβ42 peptide. Nature Chemistry. Springer Nature.
https://doi.org/10.1038/s41557-020-0452-1
chicago: Michaels, Thomas C. T., Anđela Šarić, Samo Curk, Katja Bernfur, Paolo Arosio,
Georg Meisl, Alexander J. Dear, et al. “Dynamics of Oligomer Populations Formed
during the Aggregation of Alzheimer’s Aβ42 Peptide.” Nature Chemistry.
Springer Nature, 2020. https://doi.org/10.1038/s41557-020-0452-1.
ieee: T. C. T. Michaels et al., “Dynamics of oligomer populations formed
during the aggregation of Alzheimer’s Aβ42 peptide,” Nature Chemistry,
vol. 12, no. 5. Springer Nature, pp. 445–451, 2020.
ista: Michaels TCT, Šarić A, Curk S, Bernfur K, Arosio P, Meisl G, Dear AJ, Cohen
SIA, Dobson CM, Vendruscolo M, Linse S, Knowles TPJ. 2020. Dynamics of oligomer
populations formed during the aggregation of Alzheimer’s Aβ42 peptide. Nature
Chemistry. 12(5), 445–451.
mla: Michaels, Thomas C. T., et al. “Dynamics of Oligomer Populations Formed during
the Aggregation of Alzheimer’s Aβ42 Peptide.” Nature Chemistry, vol. 12,
no. 5, Springer Nature, 2020, pp. 445–51, doi:10.1038/s41557-020-0452-1.
short: T.C.T. Michaels, A. Šarić, S. Curk, K. Bernfur, P. Arosio, G. Meisl, A.J.
Dear, S.I.A. Cohen, C.M. Dobson, M. Vendruscolo, S. Linse, T.P.J. Knowles, Nature
Chemistry 12 (2020) 445–451.
date_created: 2021-11-26T09:15:13Z
date_published: 2020-04-13T00:00:00Z
date_updated: 2021-11-26T11:21:08Z
day: '13'
doi: 10.1038/s41557-020-0452-1
extern: '1'
external_id:
pmid:
- '32303714'
fulldoi: https://doi.org/10.1038/s41557-020-0452-1
intvolume: ' 12'
issue: '5'
keyword:
- general chemical engineering
- general chemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/2020.01.08.897488
month: '04'
oa: 1
oa_version: None
page: 445-451
pmid: 1
publication: Nature Chemistry
publication_identifier:
eissn:
- 1755-4349
issn:
- 1755-4330
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1038/s41557-020-0468-6
scopus_import: '1'
status: public
title: Dynamics of oligomer populations formed during the aggregation of Alzheimer’s
Aβ42 peptide
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 12
year: '2020'
...
---
OA_type: closed access
_id: '17922'
abstract:
- lang: eng
text: Gold–thiol contacts are ubiquitous across the physical and biological sciences
in connecting organic molecules to surfaces. When thiols bind to gold in self-assembled
monolayers (SAMs) the fate of the hydrogen remains a subject of profound debate—with
implications for our understanding of their physical properties, spectroscopic
features and formation mechanism(s). Exploiting measurements of the transmission
through a molecular junction, which is highly sensitive to the nature of the molecule–electrode
contact, we demonstrate here that the nature of the gold–sulfur bond in SAMs can
be probed via single-molecule conductance measurements. Critically, we find that
SAM measurements of dithiol-terminated molecular junctions yield a significantly
lower conductance than solution measurements of the same molecule. Through numerous
control experiments, conductance noise analysis and transport calculations based
on density functional theory, we show that the gold–sulfur bond in SAMs prepared
from the solution deposition of dithiols does not have chemisorbed character,
which strongly suggests that under these widely used preparation conditions the
hydrogen is retained.
article_processing_charge: No
article_type: original
author:
- first_name: Michael S.
full_name: Inkpen, Michael S.
last_name: Inkpen
- first_name: Zhen–Fei
full_name: Liu, Zhen–Fei
last_name: Liu
- first_name: Haixing
full_name: Li, Haixing
last_name: Li
- first_name: Luis M.
full_name: Campos, Luis M.
last_name: Campos
- first_name: Jeffrey B.
full_name: Neaton, Jeffrey B.
last_name: Neaton
- first_name: Latha
full_name: Venkataraman, Latha
id: 9ebb78a5-cc0d-11ee-8322-fae086a32caf
last_name: Venkataraman
orcid: 0000-0002-6957-6089
citation:
ama: Inkpen MS, Liu Z, Li H, Campos LM, Neaton JB, Venkataraman L. Non-chemisorbed
gold–sulfur binding prevails in self-assembled monolayers. Nature Chemistry.
2019;11(4):351-358. doi:10.1038/s41557-019-0216-y
apa: Inkpen, M. S., Liu, Z., Li, H., Campos, L. M., Neaton, J. B., & Venkataraman,
L. (2019). Non-chemisorbed gold–sulfur binding prevails in self-assembled monolayers.
Nature Chemistry. Springer Nature. https://doi.org/10.1038/s41557-019-0216-y
chicago: Inkpen, Michael S., Zhen–Fei Liu, Haixing Li, Luis M. Campos, Jeffrey B.
Neaton, and Latha Venkataraman. “Non-Chemisorbed Gold–Sulfur Binding Prevails
in Self-Assembled Monolayers.” Nature Chemistry. Springer Nature, 2019.
https://doi.org/10.1038/s41557-019-0216-y.
ieee: M. S. Inkpen, Z. Liu, H. Li, L. M. Campos, J. B. Neaton, and L. Venkataraman,
“Non-chemisorbed gold–sulfur binding prevails in self-assembled monolayers,” Nature
Chemistry, vol. 11, no. 4. Springer Nature, pp. 351–358, 2019.
ista: Inkpen MS, Liu Z, Li H, Campos LM, Neaton JB, Venkataraman L. 2019. Non-chemisorbed
gold–sulfur binding prevails in self-assembled monolayers. Nature Chemistry. 11(4),
351–358.
mla: Inkpen, Michael S., et al. “Non-Chemisorbed Gold–Sulfur Binding Prevails in
Self-Assembled Monolayers.” Nature Chemistry, vol. 11, no. 4, Springer
Nature, 2019, pp. 351–58, doi:10.1038/s41557-019-0216-y.
short: M.S. Inkpen, Z. Liu, H. Li, L.M. Campos, J.B. Neaton, L. Venkataraman, Nature
Chemistry 11 (2019) 351–358.
date_created: 2024-09-09T07:48:03Z
date_published: 2019-04-01T00:00:00Z
date_updated: 2024-12-11T08:00:35Z
day: '01'
doi: 10.1038/s41557-019-0216-y
extern: '1'
external_id:
pmid:
- '30833721'
fulldoi: https://doi.org/10.1038/s41557-019-0216-y
intvolume: ' 11'
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
page: 351-358
pmid: 1
publication: Nature Chemistry
publication_identifier:
eissn:
- 1755-4349
issn:
- 1755-4330
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Non-chemisorbed gold–sulfur binding prevails in self-assembled monolayers
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2019'
...
---
OA_type: closed access
_id: '21097'
abstract:
- lang: eng
text: Translation, the mRNA-templated synthesis of peptides by the ribosome, can
be manipulated to incorporate variants of the 20 cognate amino acids. Such approaches
for expanding the range of chemical entities that can be produced by the ribosome
may accelerate the discovery of molecules that can perform functions for which
poorly folded, short peptidic sequences are ill suited. Here, we show that the
ribosome tolerates some artificial helical aromatic oligomers, so-called foldamers.
Using a flexible tRNA-acylation ribozyme—flexizyme—foldamers were attached to
tRNA, and the resulting acylated tRNAs were delivered to the ribosome to initiate
the synthesis of non-cyclic and cyclic foldamer–peptide hybrid molecules. Passing
through the ribosome exit tunnel requires the foldamers to unfold. Yet foldamers
encode sufficient folding information to influence the peptide structure once
translation is completed. We also show that in cyclic hybrids, the foldamer portion
can fold into a helix and force the peptide segment to adopt a constrained and
stretched conformation.
article_processing_charge: No
article_type: original
author:
- first_name: Joseph M.
full_name: Rogers, Joseph M.
last_name: Rogers
- first_name: Sunbum
full_name: Kwon, Sunbum
last_name: Kwon
- first_name: Simon J.
full_name: Dawson, Simon J.
last_name: Dawson
- first_name: Pradeep K
full_name: Mandal, Pradeep K
id: 6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
last_name: Mandal
orcid: 0000-0001-5996-956X
- first_name: Hiroaki
full_name: Suga, Hiroaki
last_name: Suga
- first_name: Ivan
full_name: Huc, Ivan
last_name: Huc
citation:
ama: Rogers JM, Kwon S, Dawson SJ, Mandal PK, Suga H, Huc I. Ribosomal synthesis
and folding of peptide-helical aromatic foldamer hybrids. Nature Chemistry.
2018;10(4):405-412. doi:10.1038/s41557-018-0007-x
apa: Rogers, J. M., Kwon, S., Dawson, S. J., Mandal, P. K., Suga, H., & Huc,
I. (2018). Ribosomal synthesis and folding of peptide-helical aromatic foldamer
hybrids. Nature Chemistry. Springer Nature. https://doi.org/10.1038/s41557-018-0007-x
chicago: Rogers, Joseph M., Sunbum Kwon, Simon J. Dawson, Pradeep K Mandal, Hiroaki
Suga, and Ivan Huc. “Ribosomal Synthesis and Folding of Peptide-Helical Aromatic
Foldamer Hybrids.” Nature Chemistry. Springer Nature, 2018. https://doi.org/10.1038/s41557-018-0007-x.
ieee: J. M. Rogers, S. Kwon, S. J. Dawson, P. K. Mandal, H. Suga, and I. Huc, “Ribosomal
synthesis and folding of peptide-helical aromatic foldamer hybrids,” Nature
Chemistry, vol. 10, no. 4. Springer Nature, pp. 405–412, 2018.
ista: Rogers JM, Kwon S, Dawson SJ, Mandal PK, Suga H, Huc I. 2018. Ribosomal synthesis
and folding of peptide-helical aromatic foldamer hybrids. Nature Chemistry. 10(4),
405–412.
mla: Rogers, Joseph M., et al. “Ribosomal Synthesis and Folding of Peptide-Helical
Aromatic Foldamer Hybrids.” Nature Chemistry, vol. 10, no. 4, Springer
Nature, 2018, pp. 405–12, doi:10.1038/s41557-018-0007-x.
short: J.M. Rogers, S. Kwon, S.J. Dawson, P.K. Mandal, H. Suga, I. Huc, Nature Chemistry
10 (2018) 405–412.
date_created: 2026-01-29T21:27:38Z
date_published: 2018-03-19T00:00:00Z
date_updated: 2026-02-20T08:58:10Z
day: '19'
doi: 10.1038/s41557-018-0007-x
extern: '1'
external_id:
pmid:
- '29556052'
fulldoi: https://doi.org/10.1038/s41557-018-0007-x
has_accepted_license: '1'
intvolume: ' 10'
issue: '4'
language:
- iso: eng
month: '03'
oa_version: None
page: 405-412
pmid: 1
publication: Nature Chemistry
publication_identifier:
eissn:
- 1755-4349
issn:
- 1755-4330
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1038/s41557-018-0086-8
status: public
title: Ribosomal synthesis and folding of peptide-helical aromatic foldamer hybrids
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2018'
...
---
_id: '10360'
abstract:
- lang: eng
text: Mapping free-energy landscapes has proved to be a powerful tool for studying
reaction mechanisms. Many complex biomolecular assembly processes, however, have
remained challenging to access using this approach, including the aggregation
of peptides and proteins into amyloid fibrils implicated in a range of disorders.
Here, we generalize the strategy used to probe free-energy landscapes in protein
folding to determine the activation energies and entropies that characterize each
of the molecular steps in the aggregation of the amyloid-β peptide (Aβ42), which
is associated with Alzheimer’s disease. Our results reveal that interactions between
monomeric Aβ42 and amyloid fibrils during fibril-dependent secondary nucleation
fundamentally reverse the thermodynamic signature of this process relative to
primary nucleation, even though both processes generate aggregates from soluble
peptides. By mapping the energetic and entropic contributions along the reaction
trajectories, we show that the catalytic efficiency of Aβ42 fibril surfaces results
from the enthalpic stabilization of adsorbing peptides in conformations amenable
to nucleation, resulting in a dramatic lowering of the activation energy for nucleation.
acknowledgement: We thank B. Jönsson and I. André for helpful discussions. We acknowledge
financial support from the Schiff Foundation (S.I.A.C.), St John’s College, Cambridge
(S.I.A.C.), the Royal Physiographic Society (R.C.), the Research School FLÄK of
Lund University (S.L., R.C.), the Swedish Research Council (S.L.) and its Linneaus
Centre Organizing Molecular Matter (S.L.), the Crafoord Foundation (S.L.), Alzheimerfonden
(S.L.), the European Research Council (S.L.), NanoLund (S.L.), Knut and Alice Wallenberg
Foundation (S.L.), Peterhouse, Cambridge (T.C.T.M.), the Swiss National Science
Foundation (T.C.T.M.), Magdalene College, Cambridge (A.K.B.), the Leverhulme Trust
(A.K.B.), the Royal Society (A.Š.), the Academy of Medical Sciences (A.Š.), the
Wellcome Trust (C.M.D., T.P.J.K., A.Š.), and the Centre for Misfolding Diseases
(C.M.D., T.P.J.K, M.V.). A.K.B. thanks the Alzheimer Forschung Initiative (AFI).
article_processing_charge: No
article_type: original
author:
- first_name: Samuel I. A.
full_name: Cohen, Samuel I. A.
last_name: Cohen
- first_name: Risto
full_name: Cukalevski, Risto
last_name: Cukalevski
- first_name: Thomas C. T.
full_name: Michaels, Thomas C. T.
last_name: Michaels
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Mattias
full_name: Törnquist, Mattias
last_name: Törnquist
- first_name: Michele
full_name: Vendruscolo, Michele
last_name: Vendruscolo
- first_name: Christopher M.
full_name: Dobson, Christopher M.
last_name: Dobson
- first_name: Alexander K.
full_name: Buell, Alexander K.
last_name: Buell
- first_name: Tuomas P. J.
full_name: Knowles, Tuomas P. J.
last_name: Knowles
- first_name: Sara
full_name: Linse, Sara
last_name: Linse
citation:
ama: Cohen SIA, Cukalevski R, Michaels TCT, et al. Distinct thermodynamic signatures
of oligomer generation in the aggregation of the amyloid-β peptide. Nature
Chemistry. 2018;10(5):523-531. doi:10.1038/s41557-018-0023-x
apa: Cohen, S. I. A., Cukalevski, R., Michaels, T. C. T., Šarić, A., Törnquist,
M., Vendruscolo, M., … Linse, S. (2018). Distinct thermodynamic signatures of
oligomer generation in the aggregation of the amyloid-β peptide. Nature Chemistry.
Springer Nature. https://doi.org/10.1038/s41557-018-0023-x
chicago: Cohen, Samuel I. A., Risto Cukalevski, Thomas C. T. Michaels, Anđela Šarić,
Mattias Törnquist, Michele Vendruscolo, Christopher M. Dobson, Alexander K. Buell,
Tuomas P. J. Knowles, and Sara Linse. “Distinct Thermodynamic Signatures of Oligomer
Generation in the Aggregation of the Amyloid-β Peptide.” Nature Chemistry.
Springer Nature, 2018. https://doi.org/10.1038/s41557-018-0023-x.
ieee: S. I. A. Cohen et al., “Distinct thermodynamic signatures of oligomer
generation in the aggregation of the amyloid-β peptide,” Nature Chemistry,
vol. 10, no. 5. Springer Nature, pp. 523–531, 2018.
ista: Cohen SIA, Cukalevski R, Michaels TCT, Šarić A, Törnquist M, Vendruscolo M,
Dobson CM, Buell AK, Knowles TPJ, Linse S. 2018. Distinct thermodynamic signatures
of oligomer generation in the aggregation of the amyloid-β peptide. Nature Chemistry.
10(5), 523–531.
mla: Cohen, Samuel I. A., et al. “Distinct Thermodynamic Signatures of Oligomer
Generation in the Aggregation of the Amyloid-β Peptide.” Nature Chemistry,
vol. 10, no. 5, Springer Nature, 2018, pp. 523–31, doi:10.1038/s41557-018-0023-x.
short: S.I.A. Cohen, R. Cukalevski, T.C.T. Michaels, A. Šarić, M. Törnquist, M.
Vendruscolo, C.M. Dobson, A.K. Buell, T.P.J. Knowles, S. Linse, Nature Chemistry
10 (2018) 523–531.
date_created: 2021-11-26T12:41:38Z
date_published: 2018-03-26T00:00:00Z
date_updated: 2021-11-26T15:14:00Z
day: '26'
doi: 10.1038/s41557-018-0023-x
extern: '1'
external_id:
pmid:
- '29581486'
fulldoi: https://doi.org/10.1038/s41557-018-0023-x
intvolume: ' 10'
issue: '5'
keyword:
- general chemical engineering
- general chemistry
language:
- iso: eng
month: '03'
oa_version: None
page: 523-531
pmid: 1
publication: Nature Chemistry
publication_identifier:
eissn:
- 1755-4349
issn:
- 1755-4330
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distinct thermodynamic signatures of oligomer generation in the aggregation
of the amyloid-β peptide
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 10
year: '2018'
...
---
_id: '13394'
abstract:
- lang: eng
text: The ability to guide the assembly of nanosized objects reversibly with external
stimuli, in particular light, is of fundamental importance, and it contributes
to the development of applications as diverse as nanofabrication and controlled
drug delivery. However, all the systems described to date are based on nanoparticles
(NPs) that are inherently photoresponsive, which makes their preparation cumbersome
and can markedly hamper their performance. Here we describe a conceptually new
methodology to assemble NPs reversibly using light that does not require the particles
to be functionalized with light-responsive ligands. Our strategy is based on the
use of a photoswitchable medium that responds to light in such a way that it modulates
the interparticle interactions. NP assembly proceeds quantitatively and without
apparent fatigue, both in solution and in gels. Exposing the gels to light in
a spatially controlled manner allowed us to draw images that spontaneously disappeared
after a specific period of time.
article_processing_charge: No
article_type: original
author:
- first_name: Pintu K.
full_name: Kundu, Pintu K.
last_name: Kundu
- first_name: Dipak
full_name: Samanta, Dipak
last_name: Samanta
- first_name: Ron
full_name: Leizrowice, Ron
last_name: Leizrowice
- first_name: Baruch
full_name: Margulis, Baruch
last_name: Margulis
- first_name: Hui
full_name: Zhao, Hui
last_name: Zhao
- first_name: Martin
full_name: Börner, Martin
last_name: Börner
- first_name: T.
full_name: Udayabhaskararao, T.
last_name: Udayabhaskararao
- first_name: Debasish
full_name: Manna, Debasish
last_name: Manna
- first_name: Rafal
full_name: Klajn, Rafal
id: 8e84690e-1e48-11ed-a02b-a1e6fb8bb53b
last_name: Klajn
citation:
ama: Kundu PK, Samanta D, Leizrowice R, et al. Light-controlled self-assembly of
non-photoresponsive nanoparticles. Nature Chemistry. 2015;7:646-652. doi:10.1038/nchem.2303
apa: Kundu, P. K., Samanta, D., Leizrowice, R., Margulis, B., Zhao, H., Börner,
M., … Klajn, R. (2015). Light-controlled self-assembly of non-photoresponsive
nanoparticles. Nature Chemistry. Springer Nature. https://doi.org/10.1038/nchem.2303
chicago: Kundu, Pintu K., Dipak Samanta, Ron Leizrowice, Baruch Margulis, Hui Zhao,
Martin Börner, T. Udayabhaskararao, Debasish Manna, and Rafal Klajn. “Light-Controlled
Self-Assembly of Non-Photoresponsive Nanoparticles.” Nature Chemistry.
Springer Nature, 2015. https://doi.org/10.1038/nchem.2303.
ieee: P. K. Kundu et al., “Light-controlled self-assembly of non-photoresponsive
nanoparticles,” Nature Chemistry, vol. 7. Springer Nature, pp. 646–652,
2015.
ista: Kundu PK, Samanta D, Leizrowice R, Margulis B, Zhao H, Börner M, Udayabhaskararao
T, Manna D, Klajn R. 2015. Light-controlled self-assembly of non-photoresponsive
nanoparticles. Nature Chemistry. 7, 646–652.
mla: Kundu, Pintu K., et al. “Light-Controlled Self-Assembly of Non-Photoresponsive
Nanoparticles.” Nature Chemistry, vol. 7, Springer Nature, 2015, pp. 646–52,
doi:10.1038/nchem.2303.
short: P.K. Kundu, D. Samanta, R. Leizrowice, B. Margulis, H. Zhao, M. Börner, T.
Udayabhaskararao, D. Manna, R. Klajn, Nature Chemistry 7 (2015) 646–652.
date_created: 2023-08-01T09:44:33Z
date_published: 2015-07-20T00:00:00Z
date_updated: 2024-10-14T12:17:47Z
day: '20'
doi: 10.1038/nchem.2303
extern: '1'
external_id:
pmid:
- '26201741'
fulldoi: https://doi.org/10.1038/nchem.2303
intvolume: ' 7'
keyword:
- General Chemical Engineering
- General Chemistry
language:
- iso: eng
month: '07'
oa_version: None
page: 646-652
pmid: 1
publication: Nature Chemistry
publication_identifier:
eissn:
- 1755-4349
issn:
- 1755-4330
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Light-controlled self-assembly of non-photoresponsive nanoparticles
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2015'
...
---
OA_type: closed access
_id: '17975'
abstract:
- lang: eng
text: A new intersection between reaction chemistry and electronic circuitry is
emerging from the ultraminiaturization of electronic devices. Over decades chemists
have developed a nuanced understanding of stereoelectronics to establish how the
electronic properties of molecules relate to their conformation; the recent advent
of single-molecule break-junction techniques provides the means to alter this
conformation with a level of control previously unimagined. Here we unite these
ideas by demonstrating the first single-molecule switch that operates through
a stereoelectronic effect. We demonstrate this behaviour in permethyloligosilanes
with methylthiomethyl electrode linkers. The strong σ conjugation in the oligosilane
backbone couples the stereoelectronic properties of the sulfur–methylene σ bonds
that terminate the molecule. Theoretical calculations support the existence of
three distinct dihedral conformations that differ drastically in their electronic
character. We can shift between these three species by simply lengthening or compressing
the molecular junction, and, in doing so, we can switch conductance digitally
between two states.
article_processing_charge: No
article_type: original
author:
- first_name: Timothy A.
full_name: Su, Timothy A.
last_name: Su
- first_name: Haixing
full_name: Li, Haixing
last_name: Li
- first_name: Michael L.
full_name: Steigerwald, Michael L.
last_name: Steigerwald
- first_name: Latha
full_name: Venkataraman, Latha
id: 9ebb78a5-cc0d-11ee-8322-fae086a32caf
last_name: Venkataraman
orcid: 0000-0002-6957-6089
- first_name: Colin
full_name: Nuckolls, Colin
last_name: Nuckolls
citation:
ama: Su TA, Li H, Steigerwald ML, Venkataraman L, Nuckolls C. Stereoelectronic switching
in single-molecule junctions. Nature Chemistry. 2015;7(3):215-220. doi:10.1038/nchem.2180
apa: Su, T. A., Li, H., Steigerwald, M. L., Venkataraman, L., & Nuckolls, C.
(2015). Stereoelectronic switching in single-molecule junctions. Nature Chemistry.
Springer Nature. https://doi.org/10.1038/nchem.2180
chicago: Su, Timothy A., Haixing Li, Michael L. Steigerwald, Latha Venkataraman,
and Colin Nuckolls. “Stereoelectronic Switching in Single-Molecule Junctions.”
Nature Chemistry. Springer Nature, 2015. https://doi.org/10.1038/nchem.2180.
ieee: T. A. Su, H. Li, M. L. Steigerwald, L. Venkataraman, and C. Nuckolls, “Stereoelectronic
switching in single-molecule junctions,” Nature Chemistry, vol. 7, no.
3. Springer Nature, pp. 215–220, 2015.
ista: Su TA, Li H, Steigerwald ML, Venkataraman L, Nuckolls C. 2015. Stereoelectronic
switching in single-molecule junctions. Nature Chemistry. 7(3), 215–220.
mla: Su, Timothy A., et al. “Stereoelectronic Switching in Single-Molecule Junctions.”
Nature Chemistry, vol. 7, no. 3, Springer Nature, 2015, pp. 215–20, doi:10.1038/nchem.2180.
short: T.A. Su, H. Li, M.L. Steigerwald, L. Venkataraman, C. Nuckolls, Nature Chemistry
7 (2015) 215–220.
date_created: 2024-09-09T10:54:59Z
date_published: 2015-02-16T00:00:00Z
date_updated: 2025-01-02T13:28:51Z
day: '16'
doi: 10.1038/nchem.2180
extern: '1'
external_id:
pmid:
- '25698330'
fulldoi: https://doi.org/10.1038/nchem.2180
intvolume: ' 7'
issue: '3'
language:
- iso: eng
month: '02'
oa_version: None
page: 215-220
pmid: 1
publication: Nature Chemistry
publication_identifier:
eissn:
- 1755-4349
issn:
- 1755-4330
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Stereoelectronic switching in single-molecule junctions
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2015'
...
---
OA_type: closed access
_id: '17976'
abstract:
- lang: eng
text: To develop advanced materials for electronic devices, it is of utmost importance
to design organic building blocks with tunable functionality and to study their
properties at the molecular level. For organic electronic and photovoltaic applications,
the ability to vary the nature of charge carriers and so create either electron
donors or acceptors is critical. Here we demonstrate that charge carriers in single-molecule
junctions can be tuned within a family of molecules that contain electron-deficient
thiophene-1,1-dioxide (TDO) building blocks. Oligomers of TDO were designed to
increase electron affinity and maintain delocalized frontier orbitals while significantly
decreasing the transport gap. Through thermopower measurements we show that the
dominant charge carriers change from holes to electrons as the number of TDO units
is increased. This results in a unique system in which the charge carrier depends
on the backbone length, and provides a new means to tune p- and n-type transport
in organic materials.
article_processing_charge: No
article_type: original
author:
- first_name: Emma J.
full_name: Dell, Emma J.
last_name: Dell
- first_name: Brian
full_name: Capozzi, Brian
last_name: Capozzi
- first_name: Jianlong
full_name: Xia, Jianlong
last_name: Xia
- first_name: Latha
full_name: Venkataraman, Latha
id: 9ebb78a5-cc0d-11ee-8322-fae086a32caf
last_name: Venkataraman
orcid: 0000-0002-6957-6089
- first_name: Luis M.
full_name: Campos, Luis M.
last_name: Campos
citation:
ama: Dell EJ, Capozzi B, Xia J, Venkataraman L, Campos LM. Molecular length dictates
the nature of charge carriers in single-molecule junctions of oxidized oligothiophenes.
Nature Chemistry. 2015;7(3):209-214. doi:10.1038/nchem.2160
apa: Dell, E. J., Capozzi, B., Xia, J., Venkataraman, L., & Campos, L. M. (2015).
Molecular length dictates the nature of charge carriers in single-molecule junctions
of oxidized oligothiophenes. Nature Chemistry. Springer Nature. https://doi.org/10.1038/nchem.2160
chicago: Dell, Emma J., Brian Capozzi, Jianlong Xia, Latha Venkataraman, and Luis
M. Campos. “Molecular Length Dictates the Nature of Charge Carriers in Single-Molecule
Junctions of Oxidized Oligothiophenes.” Nature Chemistry. Springer Nature,
2015. https://doi.org/10.1038/nchem.2160.
ieee: E. J. Dell, B. Capozzi, J. Xia, L. Venkataraman, and L. M. Campos, “Molecular
length dictates the nature of charge carriers in single-molecule junctions of
oxidized oligothiophenes,” Nature Chemistry, vol. 7, no. 3. Springer Nature,
pp. 209–214, 2015.
ista: Dell EJ, Capozzi B, Xia J, Venkataraman L, Campos LM. 2015. Molecular length
dictates the nature of charge carriers in single-molecule junctions of oxidized
oligothiophenes. Nature Chemistry. 7(3), 209–214.
mla: Dell, Emma J., et al. “Molecular Length Dictates the Nature of Charge Carriers
in Single-Molecule Junctions of Oxidized Oligothiophenes.” Nature Chemistry,
vol. 7, no. 3, Springer Nature, 2015, pp. 209–14, doi:10.1038/nchem.2160.
short: E.J. Dell, B. Capozzi, J. Xia, L. Venkataraman, L.M. Campos, Nature Chemistry
7 (2015) 209–214.
date_created: 2024-09-09T10:55:42Z
date_published: 2015-02-02T00:00:00Z
date_updated: 2025-01-02T13:35:46Z
day: '02'
doi: 10.1038/nchem.2160
extern: '1'
external_id:
pmid:
- '25698329'
fulldoi: https://doi.org/10.1038/nchem.2160
intvolume: ' 7'
issue: '3'
language:
- iso: eng
month: '02'
oa_version: None
page: 209-214
pmid: 1
publication: Nature Chemistry
publication_identifier:
eissn:
- 1755-4349
issn:
- 1755-4330
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular length dictates the nature of charge carriers in single-molecule
junctions of oxidized oligothiophenes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2015'
...
---
_id: '13415'
abstract:
- lang: eng
text: Systems in which nanoscale components of different types can be captured and/or
released from organic scaffolds provide a fertile basis for the construction of
dynamic, exchangeable functional materials. In such heterogeneous systems, the
components interact with one another by means of programmable, noncovalent bonding
interactions. Herein, we describe polymers that capture and release functionalized
nanoparticles selectively during redox-controlled aggregation and disaggregation,
respectively. The interactions between the polymer and the NPs are mediated by
the reversible formation of polypseudorotaxanes, and give rise to architectures
ranging from short chains composed of few nanoparticles to extended networks of
nanoparticles crosslinked by the polymer. In the latter case, the polymer/nanoparticle
aggregates precipitate from solution such that the polymer acts as a selective
‘sponge’ for the capture/release of the nanoparticles of different types.
article_processing_charge: No
article_type: original
author:
- first_name: Rafal
full_name: Klajn, Rafal
id: 8e84690e-1e48-11ed-a02b-a1e6fb8bb53b
last_name: Klajn
- first_name: Mark A.
full_name: Olson, Mark A.
last_name: Olson
- first_name: Paul J.
full_name: Wesson, Paul J.
last_name: Wesson
- first_name: Lei
full_name: Fang, Lei
last_name: Fang
- first_name: Ali
full_name: Coskun, Ali
last_name: Coskun
- first_name: Ali
full_name: Trabolsi, Ali
last_name: Trabolsi
- first_name: Siowling
full_name: Soh, Siowling
last_name: Soh
- first_name: J. Fraser
full_name: Stoddart, J. Fraser
last_name: Stoddart
- first_name: Bartosz A.
full_name: Grzybowski, Bartosz A.
last_name: Grzybowski
citation:
ama: Klajn R, Olson MA, Wesson PJ, et al. Dynamic hook-and-eye nanoparticle sponges.
Nature Chemistry. 2009;1:733-738. doi:10.1038/nchem.432
apa: Klajn, R., Olson, M. A., Wesson, P. J., Fang, L., Coskun, A., Trabolsi, A.,
… Grzybowski, B. A. (2009). Dynamic hook-and-eye nanoparticle sponges. Nature
Chemistry. Springer Nature. https://doi.org/10.1038/nchem.432
chicago: Klajn, Rafal, Mark A. Olson, Paul J. Wesson, Lei Fang, Ali Coskun, Ali
Trabolsi, Siowling Soh, J. Fraser Stoddart, and Bartosz A. Grzybowski. “Dynamic
Hook-and-Eye Nanoparticle Sponges.” Nature Chemistry. Springer Nature,
2009. https://doi.org/10.1038/nchem.432.
ieee: R. Klajn et al., “Dynamic hook-and-eye nanoparticle sponges,” Nature
Chemistry, vol. 1. Springer Nature, pp. 733–738, 2009.
ista: Klajn R, Olson MA, Wesson PJ, Fang L, Coskun A, Trabolsi A, Soh S, Stoddart
JF, Grzybowski BA. 2009. Dynamic hook-and-eye nanoparticle sponges. Nature Chemistry.
1, 733–738.
mla: Klajn, Rafal, et al. “Dynamic Hook-and-Eye Nanoparticle Sponges.” Nature
Chemistry, vol. 1, Springer Nature, 2009, pp. 733–38, doi:10.1038/nchem.432.
short: R. Klajn, M.A. Olson, P.J. Wesson, L. Fang, A. Coskun, A. Trabolsi, S. Soh,
J.F. Stoddart, B.A. Grzybowski, Nature Chemistry 1 (2009) 733–738.
date_created: 2023-08-01T09:50:23Z
date_published: 2009-12-01T00:00:00Z
date_updated: 2023-08-08T08:55:36Z
day: '01'
doi: 10.1038/nchem.432
extern: '1'
external_id:
pmid:
- '21124361'
fulldoi: https://doi.org/10.1038/nchem.432
intvolume: ' 1'
keyword:
- General Chemical Engineering
- General Chemistry
language:
- iso: eng
month: '12'
oa_version: None
page: 733-738
pmid: 1
publication: Nature Chemistry
publication_identifier:
eissn:
- 1755-4349
issn:
- 1755-4330
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dynamic hook-and-eye nanoparticle sponges
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1
year: '2009'
...