[{"corr_author":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa":1,"department":[{"_id":"BeVi"}],"abstract":[{"lang":"eng","text":"Sex-linked and autosomal loci experience different selective pressures and evolutionary dynamics. X (or Z) chromosomes are often hemizygous in males (or females), as Y (or W) chromosomes often degenerate. Such hemizygous regions can be under greater efficacy of selection, as recessive mutations are immediately exposed to selection in the heterogametic sex leading to faster adaptation and faster divergence on the X chromosome (the so-called Faster-X or Faster-Z effect). However, in young nonrecombining regions, Y/W chromosomes often have many functional genes, and many X/Z-linked loci are therefore diploid. The sheltering of recessive mutations on the X/Z by the Y/W homolog is expected to drive slower adaptation for diploid X/Z loci, i.e. a reduction in the efficacy of selection. While the Faster-X effect has been studied extensively, much less is known empirically about the evolutionary dynamics of diploid X or Z chromosomes. Here, we took advantage of published population genomic data in the female-heterogametic human parasite Schistosoma japonicum to characterize the gene content and diversity levels of the diploid and hemizygous regions of the Z chromosome. We used different metrics of selective pressures acting on genes to test for differences in the efficacy of selection in hemizygous and diploid Z regions, relative to autosomes. We found consistent patterns suggesting reduced Ne, and reduced efficacy of purifying selection, on both hemizygous and diploid Z regions. Moreover, relaxed selection was particularly pronounced for female-biased genes on the diploid Z, as predicted by recent theoretical work."}],"external_id":{"pmid":["39913672"],"isi":["001423671400001"]},"publication_identifier":{"eissn":["1759-6653"]},"acknowledgement":"The authors would like to thank three anonymous reviewers for comments and suggestions. We are also grateful to Christelle Fraïsse, Marwan Elkrewi, and Filip Ruzicka for the help in this project.","date_created":"2025-03-09T23:01:27Z","publication":"Genome Biology and Evolution","date_updated":"2025-09-30T10:49:17Z","year":"2025","type":"journal_article","_id":"19370","has_accepted_license":"1","intvolume":"        17","article_processing_charge":"Yes","title":"Reduced efficacy of selection on a young Z chromosome region of schistosoma japonicum","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"pmid":1,"date_published":"2025-02-01T00:00:00Z","OA_type":"gold","file_date_updated":"2025-03-10T08:25:59Z","language":[{"iso":"eng"}],"publisher":"Oxford University Press","volume":17,"author":[{"id":"353FAC84-AE61-11E9-8BFC-00D3E5697425","first_name":"Andrea","last_name":"Mrnjavac","full_name":"Mrnjavac, Andrea"},{"last_name":"Vicoso","full_name":"Vicoso, Beatriz","first_name":"Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306"}],"day":"01","related_material":{"link":[{"relation":"software","url":"https://git.ista.ac.at/amrnjava/schistosomes_slower_z"}],"record":[{"id":"18549","relation":"earlier_version","status":"public"}]},"scopus_import":"1","isi":1,"citation":{"apa":"Mrnjavac, A., &#38; Vicoso, B. (2025). Reduced efficacy of selection on a young Z chromosome region of schistosoma japonicum. <i>Genome Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/gbe/evaf021\">https://doi.org/10.1093/gbe/evaf021</a>","short":"A. Mrnjavac, B. Vicoso, Genome Biology and Evolution 17 (2025).","chicago":"Mrnjavac, Andrea, and Beatriz Vicoso. “Reduced Efficacy of Selection on a Young Z Chromosome Region of Schistosoma Japonicum.” <i>Genome Biology and Evolution</i>. Oxford University Press, 2025. <a href=\"https://doi.org/10.1093/gbe/evaf021\">https://doi.org/10.1093/gbe/evaf021</a>.","mla":"Mrnjavac, Andrea, and Beatriz Vicoso. “Reduced Efficacy of Selection on a Young Z Chromosome Region of Schistosoma Japonicum.” <i>Genome Biology and Evolution</i>, vol. 17, no. 2, evaf021, Oxford University Press, 2025, doi:<a href=\"https://doi.org/10.1093/gbe/evaf021\">10.1093/gbe/evaf021</a>.","ama":"Mrnjavac A, Vicoso B. Reduced efficacy of selection on a young Z chromosome region of schistosoma japonicum. <i>Genome Biology and Evolution</i>. 2025;17(2). doi:<a href=\"https://doi.org/10.1093/gbe/evaf021\">10.1093/gbe/evaf021</a>","ista":"Mrnjavac A, Vicoso B. 2025. Reduced efficacy of selection on a young Z chromosome region of schistosoma japonicum. Genome Biology and Evolution. 17(2), evaf021.","ieee":"A. Mrnjavac and B. Vicoso, “Reduced efficacy of selection on a young Z chromosome region of schistosoma japonicum,” <i>Genome Biology and Evolution</i>, vol. 17, no. 2. Oxford University Press, 2025."},"file":[{"creator":"dernst","success":1,"checksum":"e3aa993e3d6dad10cb806c243fa57408","relation":"main_file","access_level":"open_access","file_size":768371,"file_name":"2025_GBE_Mrnjavac.pdf","date_updated":"2025-03-10T08:25:59Z","file_id":"19378","date_created":"2025-03-10T08:25:59Z","content_type":"application/pdf"}],"publication_status":"published","status":"public","ddc":["570"],"issue":"2","article_number":"evaf021","month":"02","article_type":"original","oa_version":"Published Version","doi":"10.1093/gbe/evaf021","quality_controlled":"1","OA_place":"publisher"},{"volume":16,"publisher":"Oxford University Press","day":"20","related_material":{"record":[{"relation":"research_data","status":"public","id":"14705"},{"id":"19386","relation":"dissertation_contains","status":"public"},{"id":"20449","status":"public","relation":"dissertation_contains"},{"id":"20444","relation":"dissertation_contains","status":"deleted"}]},"author":[{"id":"57854184-AAE0-11E9-8D04-98D6E5697425","first_name":"Vincent K","full_name":"Bett, Vincent K","last_name":"Bett"},{"id":"2A0848E2-F248-11E8-B48F-1D18A9856A87","first_name":"Ariana","last_name":"Macon","full_name":"Macon, Ariana"},{"orcid":"0000-0002-4579-8306","first_name":"Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz","last_name":"Vicoso"},{"orcid":"0000-0002-5328-7231","first_name":"Marwan N","id":"0B46FACA-A8E1-11E9-9BD3-79D1E5697425","full_name":"Elkrewi, Marwan N","last_name":"Elkrewi"}],"DOAJ_listed":"1","scopus_import":"1","publication_status":"published","file":[{"success":1,"checksum":"106a40f10443b2e7ba66749844ebbdf1","creator":"dernst","date_created":"2024-02-26T09:54:59Z","file_id":"15029","date_updated":"2024-02-26T09:54:59Z","content_type":"application/pdf","relation":"main_file","file_size":5213306,"access_level":"open_access","file_name":"2024_GBE_Bett.pdf"}],"isi":1,"citation":{"ieee":"V. K. Bett, A. Macon, B. Vicoso, and M. N. Elkrewi, “Chromosome-level assembly of Artemia franciscana sheds light on sex chromosome differentiation,” <i>Genome Biology and Evolution</i>, vol. 16, no. 1. Oxford University Press, 2024.","ista":"Bett VK, Macon A, Vicoso B, Elkrewi MN. 2024. Chromosome-level assembly of Artemia franciscana sheds light on sex chromosome differentiation. Genome Biology and Evolution. 16(1), evae006.","mla":"Bett, Vincent K., et al. “Chromosome-Level Assembly of Artemia Franciscana Sheds Light on Sex Chromosome Differentiation.” <i>Genome Biology and Evolution</i>, vol. 16, no. 1, evae006, Oxford University Press, 2024, doi:<a href=\"https://doi.org/10.1093/gbe/evae006\">10.1093/gbe/evae006</a>.","ama":"Bett VK, Macon A, Vicoso B, Elkrewi MN. Chromosome-level assembly of Artemia franciscana sheds light on sex chromosome differentiation. <i>Genome Biology and Evolution</i>. 2024;16(1). doi:<a href=\"https://doi.org/10.1093/gbe/evae006\">10.1093/gbe/evae006</a>","chicago":"Bett, Vincent K, Ariana Macon, Beatriz Vicoso, and Marwan N Elkrewi. “Chromosome-Level Assembly of Artemia Franciscana Sheds Light on Sex Chromosome Differentiation.” <i>Genome Biology and Evolution</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/gbe/evae006\">https://doi.org/10.1093/gbe/evae006</a>.","apa":"Bett, V. K., Macon, A., Vicoso, B., &#38; Elkrewi, M. N. (2024). Chromosome-level assembly of Artemia franciscana sheds light on sex chromosome differentiation. <i>Genome Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/gbe/evae006\">https://doi.org/10.1093/gbe/evae006</a>","short":"V.K. Bett, A. Macon, B. Vicoso, M.N. Elkrewi, Genome Biology and Evolution 16 (2024)."},"ddc":["570"],"issue":"1","article_number":"evae006","status":"public","oa_version":"Published Version","month":"01","article_type":"original","doi":"10.1093/gbe/evae006","quality_controlled":"1","OA_place":"publisher","corr_author":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa":1,"department":[{"_id":"BeVi"}],"external_id":{"pmid":["38245839"],"isi":["001153952800001"]},"abstract":[{"lang":"eng","text":"Since the commercialization of brine shrimp (genus Artemia) in the 1950s, this lineage, and in particular the model species Artemia franciscana, has been the subject of extensive research. However, our understanding of the genetic mechanisms underlying various aspects of their reproductive biology, including sex determination, is still lacking. This is partly due to the scarcity of genomic resources for Artemia species and crustaceans in general. Here, we present a chromosome-level genome assembly of A. franciscana (Kellogg 1906), from the Great Salt Lake, United States. The genome is 1 GB, and the majority of the genome (81%) is scaffolded into 21 linkage groups using a previously published high-density linkage map. We performed coverage and FST analyses using male and female genomic and transcriptomic reads to quantify the extent of differentiation between the Z and W chromosomes. Additionally, we quantified the expression levels in male and female heads and gonads and found further evidence for dosage compensation in this species."}],"date_created":"2024-02-18T23:01:02Z","publication":"Genome Biology and Evolution","date_updated":"2026-06-23T22:30:52Z","year":"2024","publication_identifier":{"eissn":["1759-6653"]},"has_accepted_license":"1","_id":"15009","type":"journal_article","intvolume":"        16","pmid":1,"date_published":"2024-01-20T00:00:00Z","title":"Chromosome-level assembly of Artemia franciscana sheds light on sex chromosome differentiation","article_processing_charge":"Yes","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"language":[{"iso":"eng"}],"file_date_updated":"2024-02-26T09:54:59Z","OA_type":"gold"},{"file_date_updated":"2025-01-08T08:28:07Z","language":[{"iso":"eng"}],"OA_type":"gold","date_published":"2024-12-01T00:00:00Z","pmid":1,"tmp":{"image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"article_processing_charge":"Yes","title":"Evidence for a novel X chromosome in termites","intvolume":"        16","has_accepted_license":"1","_id":"18761","type":"journal_article","acknowledged_ssus":[{"_id":"ScienComp"}],"year":"2024","date_updated":"2025-09-09T11:58:41Z","date_created":"2025-01-05T23:01:58Z","publication":"Genome Biology and Evolution","acknowledgement":"urthermore, we thank all lab members and collaborators for feedback on the project. Specifically, Dino McMahon provided R. flavipes males and females, Judith Korb provided C. secundus males and females, gave feedback on the project and discussed questions on termite reproduction, Mireille Vasseur-Cognet provided M. natalensis males and females, Ariana Macon performed the lab work for sequencing and the Vicoso group gave critical feedback on the project. We furthermore thank the HPC group at IST Austria and Christian Meesters at JGU Mainz for their technical support.\r\nThis work was supported by a Österreichischer Wissenschaftsfonds (FWF) grant of the Meitner Programme to A.K.H. (project number M 2484), funding by the Deutsche Forschungsgemeinschaft (DFG) of the Research Training Group GenEvo (project number 407023052) to A.K.H., R.F., and A.D., and funding of the DFG within the Schwerpunktprogramm Gevol to A.K.H. and R.M. (project number 503256468).","publication_identifier":{"eissn":["1759-6653"]},"external_id":{"isi":["001380841100001"],"pmid":["39658246"]},"abstract":[{"lang":"eng","text":"Termites, together with cockroaches, belong to the Blattodea. They possess an XX/XY sex determination system which has evolved from an XX/X0 system present in other Blattodean species, such as cockroaches and wood roaches. Little is currently known about the sex chromosomes of termites, their gene content, or their evolution. We here investigate the X chromosome of multiple termite species and compare them with the X chromosome of cockroaches using genomic and transcriptomic data. We find that the X chromosome of the termite Macrotermes natalensis is large and differentiated showing hall marks of sex chromosome evolution such as dosage compensation, while this does not seem to be the case in the other two termite species investigated here where sex chromosomes may be evolutionary younger. Furthermore, the X chromosome in M. natalensis is different from the X chromosome found in the cockroach Blattella germanica indicating that sex chromosome turn-over events may have happened during termite evolution."}],"department":[{"_id":"BeVi"}],"oa":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","corr_author":"1","OA_place":"publisher","quality_controlled":"1","doi":"10.1093/gbe/evae265","oa_version":"Published Version","article_type":"original","month":"12","article_number":"evae265","ddc":["570"],"issue":"12","status":"public","publication_status":"published","isi":1,"file":[{"creator":"dernst","success":1,"checksum":"9cf8fd14580dd694dd810ccca808ad0e","file_size":795106,"relation":"main_file","access_level":"open_access","file_name":"2024_GBE_Fraser.pdf","date_updated":"2025-01-08T08:28:07Z","file_id":"18772","date_created":"2025-01-08T08:28:07Z","content_type":"application/pdf"}],"citation":{"ieee":"R. Fraser <i>et al.</i>, “Evidence for a novel X chromosome in termites,” <i>Genome Biology and Evolution</i>, vol. 16, no. 12. Oxford University Press, 2024.","apa":"Fraser, R., Moraa, R., Djolai, A., Meisenheimer, N., Laube, S., Vicoso, B., &#38; Huylmans, A. K. (2024). Evidence for a novel X chromosome in termites. <i>Genome Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/gbe/evae265\">https://doi.org/10.1093/gbe/evae265</a>","short":"R. Fraser, R. Moraa, A. Djolai, N. Meisenheimer, S. Laube, B. Vicoso, A.K. Huylmans, Genome Biology and Evolution 16 (2024).","chicago":"Fraser, Roxanne, Ruth Moraa, Annika Djolai, Nils Meisenheimer, Sophie Laube, Beatriz Vicoso, and Ann K Huylmans. “Evidence for a Novel X Chromosome in Termites.” <i>Genome Biology and Evolution</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/gbe/evae265\">https://doi.org/10.1093/gbe/evae265</a>.","ista":"Fraser R, Moraa R, Djolai A, Meisenheimer N, Laube S, Vicoso B, Huylmans AK. 2024. Evidence for a novel X chromosome in termites. Genome Biology and Evolution. 16(12), evae265.","mla":"Fraser, Roxanne, et al. “Evidence for a Novel X Chromosome in Termites.” <i>Genome Biology and Evolution</i>, vol. 16, no. 12, evae265, Oxford University Press, 2024, doi:<a href=\"https://doi.org/10.1093/gbe/evae265\">10.1093/gbe/evae265</a>.","ama":"Fraser R, Moraa R, Djolai A, et al. Evidence for a novel X chromosome in termites. <i>Genome Biology and Evolution</i>. 2024;16(12). doi:<a href=\"https://doi.org/10.1093/gbe/evae265\">10.1093/gbe/evae265</a>"},"scopus_import":"1","DOAJ_listed":"1","day":"01","author":[{"last_name":"Fraser","full_name":"Fraser, Roxanne","first_name":"Roxanne"},{"full_name":"Moraa, Ruth","last_name":"Moraa","first_name":"Ruth"},{"first_name":"Annika","last_name":"Djolai","full_name":"Djolai, Annika"},{"full_name":"Meisenheimer, Nils","last_name":"Meisenheimer","first_name":"Nils"},{"last_name":"Laube","full_name":"Laube, Sophie","first_name":"Sophie"},{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz","orcid":"0000-0002-4579-8306","full_name":"Vicoso, Beatriz","last_name":"Vicoso"},{"orcid":"0000-0001-8871-4961","first_name":"Ann K","id":"4C0A3874-F248-11E8-B48F-1D18A9856A87","last_name":"Huylmans","full_name":"Huylmans, Ann K"}],"volume":16,"publisher":"Oxford University Press","project":[{"grant_number":"M02484","call_identifier":"FWF","_id":"26641CAC-B435-11E9-9278-68D0E5697425","name":"Sex Determination in Termites"}]},{"author":[{"orcid":"0000-0003-1945-2245","first_name":"Carolina","id":"20565186-803f-11ed-ab7e-96a4ff7694ef","last_name":"De Castro Barbosa Rodrigues Barata","full_name":"De Castro Barbosa Rodrigues Barata, Carolina"},{"last_name":"Snook","full_name":"Snook, Rhonda R.","first_name":"Rhonda R."},{"full_name":"Ritchie, Michael G.","last_name":"Ritchie","first_name":"Michael G."},{"last_name":"Kosiol","full_name":"Kosiol, Carolin","first_name":"Carolin"}],"related_material":{"link":[{"relation":"software","url":"https://github.com/carolbarata/dpseudo-n-beyond"}]},"day":"01","publisher":"Oxford University Press","volume":15,"citation":{"ieee":"C. de Castro Barbosa Rodrigues Barata, R. R. Snook, M. G. Ritchie, and C. Kosiol, “Selection on the fly: Short-term adaptation to an altered sexual selection regime in Drosophila pseudoobscura,” <i>Genome biology and evolution</i>, vol. 15, no. 7. Oxford University Press, 2023.","short":"C. de Castro Barbosa Rodrigues Barata, R.R. Snook, M.G. Ritchie, C. Kosiol, Genome Biology and Evolution 15 (2023).","apa":"de Castro Barbosa Rodrigues Barata, C., Snook, R. R., Ritchie, M. G., &#38; Kosiol, C. (2023). Selection on the fly: Short-term adaptation to an altered sexual selection regime in Drosophila pseudoobscura. <i>Genome Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/gbe/evad113\">https://doi.org/10.1093/gbe/evad113</a>","chicago":"Castro Barbosa Rodrigues Barata, Carolina de, Rhonda R. Snook, Michael G. Ritchie, and Carolin Kosiol. “Selection on the Fly: Short-Term Adaptation to an Altered Sexual Selection Regime in Drosophila Pseudoobscura.” <i>Genome Biology and Evolution</i>. Oxford University Press, 2023. <a href=\"https://doi.org/10.1093/gbe/evad113\">https://doi.org/10.1093/gbe/evad113</a>.","ista":"de Castro Barbosa Rodrigues Barata C, Snook RR, Ritchie MG, Kosiol C. 2023. Selection on the fly: Short-term adaptation to an altered sexual selection regime in Drosophila pseudoobscura. Genome biology and evolution. 15(7), evad113.","mla":"de Castro Barbosa Rodrigues Barata, Carolina, et al. “Selection on the Fly: Short-Term Adaptation to an Altered Sexual Selection Regime in Drosophila Pseudoobscura.” <i>Genome Biology and Evolution</i>, vol. 15, no. 7, evad113, Oxford University Press, 2023, doi:<a href=\"https://doi.org/10.1093/gbe/evad113\">10.1093/gbe/evad113</a>.","ama":"de Castro Barbosa Rodrigues Barata C, Snook RR, Ritchie MG, Kosiol C. Selection on the fly: Short-term adaptation to an altered sexual selection regime in Drosophila pseudoobscura. <i>Genome biology and evolution</i>. 2023;15(7). doi:<a href=\"https://doi.org/10.1093/gbe/evad113\">10.1093/gbe/evad113</a>"},"isi":1,"file":[{"success":1,"checksum":"70de3c4878de6efe00dc56de2df8812f","creator":"dernst","date_updated":"2023-08-01T06:58:34Z","file_id":"13339","date_created":"2023-08-01T06:58:34Z","content_type":"application/pdf","file_size":2382587,"relation":"main_file","access_level":"open_access","file_name":"2023_GBE_Barata.pdf"}],"publication_status":"published","scopus_import":"1","article_type":"original","month":"07","oa_version":"Published Version","status":"public","article_number":"evad113","issue":"7","ddc":["570"],"quality_controlled":"1","doi":"10.1093/gbe/evad113","department":[{"_id":"BeVi"}],"oa":1,"corr_author":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"This work was supported by the Vienna Science and Technology Fund (WWTF)(10.47379/MA16061). C.K. received funding from the Royal Society (RG170315) and the Carnegie Trust (RIG007474). M.G.R. and R.R.S. have been supported by NERC (UK) grants NE/I014632/1 and NE/V001566/1. Bioinformatics analyses were performed on the computer cluster at the University of St Andrews Bioinformatics Unit, which is funded by Wellcome Trust ISSF awards 105621/Z/14/Z. Complementary data parsing was carried out with the computational resources provided by the Research/Scientific Computing teams at The James Hutton Institute and the National Institute of Agricultural Botany (NIAB)—UK’s Crop Diversity Bioinformatics HPC, BBSRC grant BB/S019669/1. We are thankful to Paris Veltsos and R. Axel W. Wiberg for useful discussions about the project as well as providing us with the resequencing data they had produced as a result of previous work on this experiment. We are especially grateful to Tanya Sneddon for her help with the DNA extraction process and shipping.","publication_identifier":{"eissn":["1759-6653"]},"year":"2023","date_updated":"2025-05-14T11:08:37Z","date_created":"2023-07-23T22:01:11Z","publication":"Genome biology and evolution","abstract":[{"lang":"eng","text":"Experimental evolution studies are powerful approaches to examine the evolutionary history of lab populations. Such studies have shed light on how selection changes phenotypes and genotypes. Most of these studies have not examined the time course of adaptation under sexual selection manipulation, by resequencing the populations’ genomes at multiple time points. Here, we analyze allele frequency trajectories in Drosophila pseudoobscura where we altered their sexual selection regime for 200 generations and sequenced pooled populations at 5 time points. The intensity of sexual selection was either relaxed in monogamous populations (M) or elevated in polyandrous lines (E). We present a comprehensive study of how selection alters population genetics parameters at the chromosome and gene level. We investigate differences in the effective population size—Ne—between the treatments, and perform a genome-wide scan to identify signatures of selection from the time-series data. We found genomic signatures of adaptation to both regimes in D. pseudoobscura. There are more significant variants in E lines as expected from stronger sexual selection. However, we found that the response on the X chromosome was substantial in both treatments, more pronounced in E and restricted to the more recently sex-linked chromosome arm XR in M. In the first generations of experimental evolution, we estimate Ne to be lower on the X in E lines, which might indicate a swift adaptive response at the onset of selection. Additionally, the third chromosome was affected by elevated polyandry whereby its distal end harbors a region showing a strong signal of adaptive evolution especially in E lines."}],"external_id":{"pmid":["37341535"],"isi":["001023444700003"]},"intvolume":"        15","_id":"13260","type":"journal_article","has_accepted_license":"1","file_date_updated":"2023-08-01T06:58:34Z","language":[{"iso":"eng"}],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"article_processing_charge":"Yes","title":"Selection on the fly: Short-term adaptation to an altered sexual selection regime in Drosophila pseudoobscura","date_published":"2023-07-01T00:00:00Z","pmid":1},{"volume":11,"project":[{"name":"Prevalence and Influence of Sexual Antagonism on Genome Evolution","call_identifier":"H2020","grant_number":"715257","_id":"250BDE62-B435-11E9-9278-68D0E5697425"}],"publisher":"Oxford University Press","day":"01","related_material":{"record":[{"id":"6060","relation":"popular_science","status":"public"}]},"author":[{"last_name":"Huylmans","full_name":"Huylmans, Ann K","orcid":"0000-0001-8871-4961","first_name":"Ann K","id":"4C0A3874-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Toups","full_name":"Toups, Melissa A","first_name":"Melissa A","id":"4E099E4E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9752-7380"},{"full_name":"Macon, Ariana","last_name":"Macon","first_name":"Ariana","id":"2A0848E2-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Gammerdinger, William J","last_name":"Gammerdinger","id":"3A7E01BC-F248-11E8-B48F-1D18A9856A87","first_name":"William J","orcid":"0000-0001-9638-1220"},{"last_name":"Vicoso","full_name":"Vicoso, Beatriz","first_name":"Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306"}],"scopus_import":"1","ec_funded":1,"publication_status":"published","page":"1033-1044","file":[{"checksum":"7d0ede297b6741f3dc89cd59017c7642","creator":"dernst","content_type":"application/pdf","date_created":"2019-05-14T08:29:38Z","file_id":"6446","date_updated":"2020-07-14T12:47:29Z","file_name":"2019_GBE_Huylmans.pdf","access_level":"open_access","relation":"main_file","file_size":1256303}],"citation":{"short":"A.K. Huylmans, M.A. Toups, A. Macon, W.J. Gammerdinger, B. Vicoso, Genome Biology and Evolution 11 (2019) 1033–1044.","apa":"Huylmans, A. K., Toups, M. A., Macon, A., Gammerdinger, W. J., &#38; Vicoso, B. (2019). Sex-biased gene expression and dosage compensation on the Artemia franciscana Z-chromosome. <i>Genome Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/gbe/evz053\">https://doi.org/10.1093/gbe/evz053</a>","mla":"Huylmans, Ann K., et al. “Sex-Biased Gene Expression and Dosage Compensation on the Artemia Franciscana Z-Chromosome.” <i>Genome Biology and Evolution</i>, vol. 11, no. 4, Oxford University Press, 2019, pp. 1033–44, doi:<a href=\"https://doi.org/10.1093/gbe/evz053\">10.1093/gbe/evz053</a>.","ista":"Huylmans AK, Toups MA, Macon A, Gammerdinger WJ, Vicoso B. 2019. Sex-biased gene expression and dosage compensation on the Artemia franciscana Z-chromosome. Genome biology and evolution. 11(4), 1033–1044.","chicago":"Huylmans, Ann K, Melissa A Toups, Ariana Macon, William J Gammerdinger, and Beatriz Vicoso. “Sex-Biased Gene Expression and Dosage Compensation on the Artemia Franciscana Z-Chromosome.” <i>Genome Biology and Evolution</i>. Oxford University Press, 2019. <a href=\"https://doi.org/10.1093/gbe/evz053\">https://doi.org/10.1093/gbe/evz053</a>.","ama":"Huylmans AK, Toups MA, Macon A, Gammerdinger WJ, Vicoso B. Sex-biased gene expression and dosage compensation on the Artemia franciscana Z-chromosome. <i>Genome biology and evolution</i>. 2019;11(4):1033-1044. doi:<a href=\"https://doi.org/10.1093/gbe/evz053\">10.1093/gbe/evz053</a>","ieee":"A. K. Huylmans, M. A. Toups, A. Macon, W. J. Gammerdinger, and B. Vicoso, “Sex-biased gene expression and dosage compensation on the Artemia franciscana Z-chromosome,” <i>Genome biology and evolution</i>, vol. 11, no. 4. Oxford University Press, pp. 1033–1044, 2019."},"isi":1,"issue":"4","ddc":["570"],"status":"public","oa_version":"Published Version","month":"04","quality_controlled":"1","doi":"10.1093/gbe/evz053","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"department":[{"_id":"BeVi"}],"external_id":{"isi":["000476569800003"]},"abstract":[{"text":"Males and females of Artemia franciscana, a crustacean commonly used in the aquarium trade, are highly dimorphic. Sex is determined by a pair of ZW chromosomes, but the nature and extent of differentiation of these chromosomes is unknown. Here, we characterize the Z chromosome by detecting genomic regions that show lower genomic coverage in female than in male samples, and regions that harbor an excess of female-specific SNPs. We detect many Z-specific genes, which no longer have homologs on the W, but also Z-linked genes that appear to have diverged very recently from their existing W-linked homolog. We assess patterns of male and female expression in two tissues with extensive morphological dimorphism, gonads, and heads. In agreement with their morphology, sex-biased expression is common in both tissues. Interestingly, the Z chromosome is not enriched for sex-biased genes, and seems to in fact have a mechanism of dosage compensation that leads to equal expression in males and in females. Both of these patterns are contrary to most ZW systems studied so far, making A. franciscana an excellent model for investigating the interplay between the evolution of sexual dimorphism and dosage compensation, as well as Z chromosome evolution in general.","lang":"eng"}],"date_created":"2019-05-13T07:58:38Z","publication":"Genome biology and evolution","year":"2019","date_updated":"2025-04-14T07:41:21Z","publication_identifier":{"eissn":["1759-6653"]},"has_accepted_license":"1","_id":"6418","type":"journal_article","acknowledged_ssus":[{"_id":"ScienComp"}],"intvolume":"        11","date_published":"2019-04-01T00:00:00Z","title":"Sex-biased gene expression and dosage compensation on the Artemia franciscana Z-chromosome","article_processing_charge":"No","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file_date_updated":"2020-07-14T12:47:29Z","language":[{"iso":"eng"}]},{"author":[{"full_name":"Picard, Marion A L","last_name":"Picard","first_name":"Marion A L","id":"2C921A7A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8101-2518"},{"full_name":"Vicoso, Beatriz","last_name":"Vicoso","orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz"},{"full_name":"Roquis, David","last_name":"Roquis","first_name":"David"},{"first_name":"Ingo","full_name":"Bulla, Ingo","last_name":"Bulla"},{"last_name":"Augusto","full_name":"Augusto, Ronaldo C.","first_name":"Ronaldo C."},{"full_name":"Arancibia, Nathalie","last_name":"Arancibia","first_name":"Nathalie"},{"full_name":"Grunau, Christoph","last_name":"Grunau","first_name":"Christoph"},{"last_name":"Boissier","full_name":"Boissier, Jérôme","first_name":"Jérôme"},{"first_name":"Céline","full_name":"Cosseau, Céline","last_name":"Cosseau"}],"day":"01","publisher":"Oxford University Press","volume":11,"isi":1,"file":[{"file_name":"2019_GenomeBiology_Picard.pdf","relation":"main_file","file_size":580205,"access_level":"open_access","content_type":"application/pdf","date_created":"2019-08-05T07:55:02Z","date_updated":"2020-07-14T12:47:39Z","file_id":"6765","creator":"dernst","checksum":"f9e8f6863a406dcc5a36b2be001c138c"}],"citation":{"short":"M.A.L. Picard, B. Vicoso, D. Roquis, I. Bulla, R.C. Augusto, N. Arancibia, C. Grunau, J. Boissier, C. Cosseau, Genome Biology and Evolution 11 (2019) 1909–1922.","apa":"Picard, M. A. L., Vicoso, B., Roquis, D., Bulla, I., Augusto, R. C., Arancibia, N., … Cosseau, C. (2019). Dosage compensation throughout the Schistosoma mansoni lifecycle: Specific chromatin landscape of the Z chromosome. <i>Genome Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/gbe/evz133\">https://doi.org/10.1093/gbe/evz133</a>","chicago":"Picard, Marion A L, Beatriz Vicoso, David Roquis, Ingo Bulla, Ronaldo C. Augusto, Nathalie Arancibia, Christoph Grunau, Jérôme Boissier, and Céline Cosseau. “Dosage Compensation throughout the Schistosoma Mansoni Lifecycle: Specific Chromatin Landscape of the Z Chromosome.” <i>Genome Biology and Evolution</i>. Oxford University Press, 2019. <a href=\"https://doi.org/10.1093/gbe/evz133\">https://doi.org/10.1093/gbe/evz133</a>.","mla":"Picard, Marion A. L., et al. “Dosage Compensation throughout the Schistosoma Mansoni Lifecycle: Specific Chromatin Landscape of the Z Chromosome.” <i>Genome Biology and Evolution</i>, vol. 11, no. 7, Oxford University Press, 2019, pp. 1909–22, doi:<a href=\"https://doi.org/10.1093/gbe/evz133\">10.1093/gbe/evz133</a>.","ista":"Picard MAL, Vicoso B, Roquis D, Bulla I, Augusto RC, Arancibia N, Grunau C, Boissier J, Cosseau C. 2019. Dosage compensation throughout the Schistosoma mansoni lifecycle: Specific chromatin landscape of the Z chromosome. Genome biology and evolution. 11(7), 1909–1922.","ama":"Picard MAL, Vicoso B, Roquis D, et al. Dosage compensation throughout the Schistosoma mansoni lifecycle: Specific chromatin landscape of the Z chromosome. <i>Genome biology and evolution</i>. 2019;11(7):1909-1922. doi:<a href=\"https://doi.org/10.1093/gbe/evz133\">10.1093/gbe/evz133</a>","ieee":"M. A. L. Picard <i>et al.</i>, “Dosage compensation throughout the Schistosoma mansoni lifecycle: Specific chromatin landscape of the Z chromosome,” <i>Genome biology and evolution</i>, vol. 11, no. 7. Oxford University Press, pp. 1909–1922, 2019."},"page":"1909-1922","publication_status":"published","scopus_import":"1","month":"07","article_type":"original","oa_version":"Published Version","status":"public","issue":"7","ddc":["570"],"quality_controlled":"1","doi":"10.1093/gbe/evz133","department":[{"_id":"BeVi"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"publication_identifier":{"eissn":["1759-6653"]},"publication":"Genome biology and evolution","date_created":"2019-08-04T21:59:18Z","year":"2019","date_updated":"2025-05-14T11:08:50Z","abstract":[{"text":"Differentiated sex chromosomes are accompanied by a difference in gene dose between X/Z-specific and autosomal genes. At the transcriptomic level, these sex-linked genes can lead to expression imbalance, or gene dosage can be compensated by epigenetic mechanisms and results into expression level equalization. Schistosoma mansoni has been previously described as a ZW species (i.e., female heterogamety, in opposition to XY male heterogametic species) with a partial dosage compensation, but underlying mechanisms are still unexplored. Here, we combine transcriptomic (RNA-Seq) and epigenetic data (ChIP-Seq against H3K4me3, H3K27me3,andH4K20me1histonemarks) in free larval cercariae and intravertebrate parasitic stages. For the first time, we describe differences in dosage compensation status in ZW females, depending on the parasitic status: free cercariae display global dosage compensation, whereas intravertebrate stages show a partial dosage compensation. We also highlight regional differences of gene expression along the Z chromosome in cercariae, but not in the intravertebrate stages. Finally, we feature a consistent permissive chromatin landscape of the Z chromosome in both sexes and stages. We argue that dosage compensation in schistosomes is characterized by chromatin remodeling mechanisms in the Z-specific region.","lang":"eng"}],"external_id":{"pmid":["31273378"],"isi":["000484039500018"]},"intvolume":"        11","_id":"6755","type":"journal_article","acknowledged_ssus":[{"_id":"CampIT"}],"has_accepted_license":"1","file_date_updated":"2020-07-14T12:47:39Z","language":[{"iso":"eng"}],"title":"Dosage compensation throughout the Schistosoma mansoni lifecycle: Specific chromatin landscape of the Z chromosome","article_processing_charge":"No","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"pmid":1,"date_published":"2019-07-01T00:00:00Z"}]