@article{6896,
  abstract     = {Until recently, a great amount of brain studies have been conducted in human post mortem tissues, cell lines and model organisms. These researches provided useful insights regarding cell-cell interactions occurring in the brain. However, such approaches suffer from technical limitations and inaccurate modeling of the tissue 3D cytoarchitecture. Importantly, they might lack a human genetic background essential for disease modeling. With the development of protocols to generate human cerebral organoids, we are now closer to reproducing the early stages of human brain development in vitro. As a result, more relevant cell-cell interaction studies can be conducted.

In this review, we discuss the advantages of 3D cultures over 2D in modulating brain cell-cell interactions during physiological and pathological development, as well as the progress made in developing organoids in which neurons, macroglia, microglia and vascularization are present. Finally, we debate the limitations of those models and possible future directions.},
  author       = {Oliveira, Bárbara and Yahya, Aysan Çerağ and Novarino, Gaia},
  issn         = {1872-6240},
  journal      = {Brain Research},
  publisher    = {Elsevier},
  title        = {{Modeling cell-cell interactions in the brain using cerebral organoids}},
  doi          = {10.1016/j.brainres.2019.146458},
  volume       = {1724},
  year         = {2019},
}

@article{2526,
  abstract     = {When WGA-HRP (wheat germ agglutinin-horseradish peroxidase conjugate) or HRP was injected into the regions around the superior central and/or the dorsal raphe nuclei in the cat, cell bodies of a number of non-pyramidal neurons were labeled in Ammon's horn. Thus the existence of direct projections from non-pyramidal neurons in Ammon's horn to the rostral raphe regions in the brainstem was suggested in the cat.},
  author       = {Ino, Tadashi and Itoh, Kazuo and Kamiya, Hiroto and Kaneko, Takeshi and Shigemoto, Ryuichi and Akiguchi, Ichiro and Mizuno, Noboru},
  issn         = {1872-6240},
  journal      = {Brain Research},
  number       = {1},
  pages        = {157 -- 161},
  publisher    = {Elsevier},
  title        = {{Direct projections from Ammon's horn to the rostral raphe regions in the brainstem of the cat}},
  doi          = {10.1016/0006-8993(89)91346-2},
  volume       = {479},
  year         = {1989},
}

@article{2522,
  abstract     = {Non-pyramidal neurons in cat Ammon's horn were shown to send their axons to the supramammillary regions (SMR), i.e. the supramammillary nucleus and its vicinities including the supramammillary nucleus and the lateral, posterior and dorsal hypothalamic areas: wheat germ agglutinin-horseradish peroxidase (WGA-HRP) injection into Ammon's horn resulted in labeling of presumed axon terminals in the SMR; and after injecting HRP into the SMR, retrogradely labeled non-pyramidal neurons were seen in Ammon's horn.},
  author       = {Ino, Tadashi and Itoh, Kazuo and Kamiya, Hiroto and Shigemoto, Ryuichi and Akiguchi, Ichiro and Mizuno, Noboru},
  issn         = {1872-6240},
  journal      = {Brain Research},
  number       = {1},
  pages        = {173 -- 177},
  publisher    = {Elsevier},
  title        = {{Direct projections of non-pyramidal neurons of Ammon's horn to the supramammillary region in the cat}},
  doi          = {10.1016/0006-8993(88)91219-X},
  volume       = {460},
  year         = {1988},
}

@article{2524,
  abstract     = {Alpha-ketoglutamate (α-KG) reductive amination activity in rat brain was found to be mostly absorbed with an antibody against liver glutamate dehydrogenase. With this and anti-glutamine synthetase antibodies, α-KG reductive amination activity was immunocytochemically shown to coexist with glutamine synthetase activity in astrocytes. The results suggest that astrocytes de novo synthesize glutamate from α-KG and ammonia, and metabolize it to glutamine.},
  author       = {Kaneko, Takeshi and Shigemoto, Ryuichi and Mizuno, Noboru},
  issn         = {1872-6240},
  journal      = {Brain Research},
  number       = {1},
  pages        = {160 -- 164},
  publisher    = {Elsevier},
  title        = {{Metabolism of glutamate and ammonia in astrocyte an immunocytochemical study}},
  doi          = {10.1016/0006-8993(88)90069-8},
  volume       = {457},
  year         = {1988},
}