@article{2637,
  abstract     = {While the cholinergic depletion in Alzheimer's disease (AD) has been known for some time, a definitive involvement of other neurotransmitter systems has been somewhat more elusive. Our study demonstrates a clear involvement of both glutamatergic and, to a lesser extent, GABAergic neurons in an early onset transgenic mouse model of AD-like amyloid pathology. Immunohistochemical staining and subsequent quantification has revealed a statistically significant increased density of glutamatergic and GABAergic presynaptic boutons in both the plaque free and plaque adjacent cortical neuropile areas of transgenic mice as compared to non-transgenic controls. Furthermore, amyloid plaque size was shown to have a statistically significant effect on the relative area occupied by dystrophic glutamatergic neurites in the peri-plaque neuropile. These findings support our hypothesis that the amyloid pathology progresses in a time and neurotransmitter specific manner, first in the cholinergic system which appears to be most vulnerable, followed by the glutamatergic presynaptic boutons and finally the somewhat more resilient GABAergic terminals.},
  author       = {Bell, Karen and De Kort, G J and Steggerda, S and Shigemoto, Ryuichi and Ribeiro Da Silva, Alfredo and Cuello, Augusto},
  issn         = {1872-7972},
  journal      = {Neuroscience Letters},
  number       = {2},
  pages        = {143 -- 147},
  publisher    = {Elsevier},
  title        = {{Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology}},
  doi          = {10.1016/j.neulet.2003.09.027},
  volume       = {353},
  year         = {2003},
}

@article{2523,
  abstract     = {Injection of large amounts of a mixture of horseradish peroxidase and wheat germ agglutinin-horseradish peroxidase conjugate into the upper cervical segments of the spinal cord in the Japanese monkey (Macaca fuscata) led to the retrograde labeling of a small number of neuronal cell bodies within the rostral part of the subthalamic nucleus of Luys. Direct projection from the subthalamic nucleus to the spinal cord appeared to be much less prominent in the Japanese monkey than in the cat and rat.},
  author       = {Mizuno, Noboru and Ueyama, Teizo and Itoh, Kazuo and Satoda, Takahiro and Tashiro, Takashi and Shigemoto, Ryuichi},
  issn         = {1872-7972},
  journal      = {Neuroscience Letters},
  number       = {1},
  pages        = {13 -- 18},
  publisher    = {Elsevier},
  title        = {{Direct projections from the subthalamic nucleus of Luys to the spinal cord in the Japanese monkey}},
  doi          = {10.1016/0304-3940(88)90473-9},
  volume       = {89},
  year         = {1988},
}