[{"status":"public","article_processing_charge":"No","publication":"Neuroscience Letters","external_id":{"pmid":["14664921"]},"abstract":[{"lang":"eng","text":"While the cholinergic depletion in Alzheimer's disease (AD) has been known for some time, a definitive involvement of other neurotransmitter systems has been somewhat more elusive. Our study demonstrates a clear involvement of both glutamatergic and, to a lesser extent, GABAergic neurons in an early onset transgenic mouse model of AD-like amyloid pathology. Immunohistochemical staining and subsequent quantification has revealed a statistically significant increased density of glutamatergic and GABAergic presynaptic boutons in both the plaque free and plaque adjacent cortical neuropile areas of transgenic mice as compared to non-transgenic controls. Furthermore, amyloid plaque size was shown to have a statistically significant effect on the relative area occupied by dystrophic glutamatergic neurites in the peri-plaque neuropile. These findings support our hypothesis that the amyloid pathology progresses in a time and neurotransmitter specific manner, first in the cholinergic system which appears to be most vulnerable, followed by the glutamatergic presynaptic boutons and finally the somewhat more resilient GABAergic terminals."}],"year":"2003","page":"143 - 147","language":[{"iso":"eng"}],"month":"12","doi":"10.1016/j.neulet.2003.09.027","article_type":"original","publication_status":"published","type":"journal_article","publication_identifier":{"issn":["0304-3940"],"eissn":["1872-7972"]},"intvolume":"       353","author":[{"first_name":"Karen","full_name":"Bell, Karen","last_name":"Bell"},{"first_name":"G J","full_name":"De Kort, G J","last_name":"De Kort"},{"last_name":"Steggerda","full_name":"Steggerda, S","first_name":"S"},{"orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi"},{"first_name":"Alfredo","full_name":"Ribeiro Da Silva, Alfredo","last_name":"Ribeiro Da Silva"},{"first_name":"Augusto","last_name":"Cuello","full_name":"Cuello, Augusto"}],"volume":353,"day":"19","title":"Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology","publisher":"Elsevier","date_published":"2003-12-19T00:00:00Z","oa_version":"None","publist_id":"4262","_id":"2637","quality_controlled":"1","OA_type":"closed access","date_created":"2018-12-11T11:58:48Z","issue":"2","pmid":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","citation":{"ista":"Bell K, De Kort GJ, Steggerda S, Shigemoto R, Ribeiro Da Silva A, Cuello A. 2003. Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology. Neuroscience Letters. 353(2), 143–147.","ama":"Bell K, De Kort GJ, Steggerda S, Shigemoto R, Ribeiro Da Silva A, Cuello A. Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology. <i>Neuroscience Letters</i>. 2003;353(2):143-147. doi:<a href=\"https://doi.org/10.1016/j.neulet.2003.09.027\">10.1016/j.neulet.2003.09.027</a>","apa":"Bell, K., De Kort, G. J., Steggerda, S., Shigemoto, R., Ribeiro Da Silva, A., &#38; Cuello, A. (2003). Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology. <i>Neuroscience Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neulet.2003.09.027\">https://doi.org/10.1016/j.neulet.2003.09.027</a>","short":"K. Bell, G.J. De Kort, S. Steggerda, R. Shigemoto, A. Ribeiro Da Silva, A. Cuello, Neuroscience Letters 353 (2003) 143–147.","mla":"Bell, Karen, et al. “Structural Involvement of the Glutamatergic Presynaptic Boutons in a Transgenic Mouse Model Expressing Early Onset Amyloid Pathology.” <i>Neuroscience Letters</i>, vol. 353, no. 2, Elsevier, 2003, pp. 143–47, doi:<a href=\"https://doi.org/10.1016/j.neulet.2003.09.027\">10.1016/j.neulet.2003.09.027</a>.","chicago":"Bell, Karen, G J De Kort, S Steggerda, Ryuichi Shigemoto, Alfredo Ribeiro Da Silva, and Augusto Cuello. “Structural Involvement of the Glutamatergic Presynaptic Boutons in a Transgenic Mouse Model Expressing Early Onset Amyloid Pathology.” <i>Neuroscience Letters</i>. Elsevier, 2003. <a href=\"https://doi.org/10.1016/j.neulet.2003.09.027\">https://doi.org/10.1016/j.neulet.2003.09.027</a>.","ieee":"K. Bell, G. J. De Kort, S. Steggerda, R. Shigemoto, A. Ribeiro Da Silva, and A. Cuello, “Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology,” <i>Neuroscience Letters</i>, vol. 353, no. 2. Elsevier, pp. 143–147, 2003."},"date_updated":"2026-05-22T09:46:51Z","scopus_import":"1","extern":"1"},{"publisher":"Elsevier","date_published":"1988-06-17T00:00:00Z","oa_version":"None","acknowledgement":"The photographic help of Mr Akira Uesugi and Mr Kenichl Uesugi, and the support of the Niwa Medical Research Foundation are gratefully acknowledged. This work has also been supported in part by Grants-ln-Aid for General Scientific Research Nos 59480095 and 62480098 from the Ministry of Education, Science and Culture of Japan","title":"Direct projections from the subthalamic nucleus of Luys to the spinal cord in the Japanese monkey","publist_id":"4377","_id":"2523","date_created":"2018-12-11T11:58:10Z","issue":"1","pmid":1,"quality_controlled":"1","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0304394088904739?via%3Dihub"}],"citation":{"apa":"Mizuno, N., Ueyama, T., Itoh, K., Satoda, T., Tashiro, T., &#38; Shigemoto, R. (1988). Direct projections from the subthalamic nucleus of Luys to the spinal cord in the Japanese monkey. <i>Neuroscience Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/0304-3940(88)90473-9\">https://doi.org/10.1016/0304-3940(88)90473-9</a>","short":"N. Mizuno, T. Ueyama, K. Itoh, T. Satoda, T. Tashiro, R. Shigemoto, Neuroscience Letters 89 (1988) 13–18.","ista":"Mizuno N, Ueyama T, Itoh K, Satoda T, Tashiro T, Shigemoto R. 1988. Direct projections from the subthalamic nucleus of Luys to the spinal cord in the Japanese monkey. Neuroscience Letters. 89(1), 13–18.","ama":"Mizuno N, Ueyama T, Itoh K, Satoda T, Tashiro T, Shigemoto R. Direct projections from the subthalamic nucleus of Luys to the spinal cord in the Japanese monkey. <i>Neuroscience Letters</i>. 1988;89(1):13-18. doi:<a href=\"https://doi.org/10.1016/0304-3940(88)90473-9\">10.1016/0304-3940(88)90473-9</a>","ieee":"N. Mizuno, T. Ueyama, K. Itoh, T. Satoda, T. Tashiro, and R. Shigemoto, “Direct projections from the subthalamic nucleus of Luys to the spinal cord in the Japanese monkey,” <i>Neuroscience Letters</i>, vol. 89, no. 1. Elsevier, pp. 13–18, 1988.","mla":"Mizuno, Noboru, et al. “Direct Projections from the Subthalamic Nucleus of Luys to the Spinal Cord in the Japanese Monkey.” <i>Neuroscience Letters</i>, vol. 89, no. 1, Elsevier, 1988, pp. 13–18, doi:<a href=\"https://doi.org/10.1016/0304-3940(88)90473-9\">10.1016/0304-3940(88)90473-9</a>.","chicago":"Mizuno, Noboru, Teizo Ueyama, Kazuo Itoh, Takahiro Satoda, Takashi Tashiro, and Ryuichi Shigemoto. “Direct Projections from the Subthalamic Nucleus of Luys to the Spinal Cord in the Japanese Monkey.” <i>Neuroscience Letters</i>. Elsevier, 1988. <a href=\"https://doi.org/10.1016/0304-3940(88)90473-9\">https://doi.org/10.1016/0304-3940(88)90473-9</a>."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-02-08T15:20:07Z","scopus_import":"1","extern":"1","status":"public","year":"1988","page":"13 - 18","language":[{"iso":"eng"}],"article_processing_charge":"No","publication":"Neuroscience Letters","external_id":{"pmid":["2456494"]},"abstract":[{"lang":"eng","text":"Injection of large amounts of a mixture of horseradish peroxidase and wheat germ agglutinin-horseradish peroxidase conjugate into the upper cervical segments of the spinal cord in the Japanese monkey (Macaca fuscata) led to the retrograde labeling of a small number of neuronal cell bodies within the rostral part of the subthalamic nucleus of Luys. Direct projection from the subthalamic nucleus to the spinal cord appeared to be much less prominent in the Japanese monkey than in the cat and rat."}],"article_type":"original","publication_status":"published","type":"journal_article","month":"06","doi":"10.1016/0304-3940(88)90473-9","volume":89,"intvolume":"        89","author":[{"full_name":"Mizuno, Noboru","last_name":"Mizuno","first_name":"Noboru"},{"first_name":"Teizo","last_name":"Ueyama","full_name":"Ueyama, Teizo"},{"first_name":"Kazuo","last_name":"Itoh","full_name":"Itoh, Kazuo"},{"first_name":"Takahiro","last_name":"Satoda","full_name":"Satoda, Takahiro"},{"full_name":"Tashiro, Takashi","last_name":"Tashiro","first_name":"Takashi"},{"full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444"}],"day":"17","publication_identifier":{"eissn":["1872-7972"],"issn":["0304-3940"]}}]