[{"year":"2005","publication_status":"published","extern":"1","publist_id":"4241","title":"Morphological evidence for GABA/glycine-cocontaining terminals in synaptic contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat","author":[{"first_name":"Yu","last_name":"Feng","full_name":"Feng, Yu"},{"full_name":"Li, Yun","last_name":"Li","first_name":"Yun"},{"last_name":"Wang","first_name":"Wen","full_name":"Wang, Wen"},{"full_name":"Wu, Sheng","first_name":"Sheng","last_name":"Wu"},{"last_name":"Chen","first_name":"Tao","full_name":"Chen, Tao"},{"first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Noboru","last_name":"Mizuno","full_name":"Mizuno, Noboru"}],"date_published":"2005-11-18T00:00:00Z","external_id":{"pmid":["16043285 "]},"issue":"3","publisher":"Elsevier","article_processing_charge":"No","_id":"2656","publication":"Neuroscience Letters","volume":388,"status":"public","language":[{"iso":"eng"}],"intvolume":"       388","abstract":[{"lang":"eng","text":"Previous studies have shown that neurons in the sacral dorsal commissural nucleus (SDCN) express neurokinin-1 receptor (NK1R) and can be modulated by the co-release of GABA and glycine (Gly) from single presynaptic terminal. These results raise the possibility that GABA/Gly-cocontaining terminals might make synaptic contacts with NK1R-expressing neurons in the SDCN. In order to provide morphological evidence for this hypothesis, the triple-immunohistochemical studies were performed in the SDCN. Triple-immunofluorescence histochemical study showed that some axon terminals in close association with NK1R-immunopositive (NK1R-ip) neurons in the SDCN were immunopositive for both glutamic acid decarboxylase (GAD) and glycine transporter 2 (GlyT2). In electron microscopic dual- and triple-immunohistochemistry for GAD/GlyT2, GAD/NK1R, GlyT2/NK1R, or GAD/GlyT2/NK1R also revealed dually labeled (GAD/GlyT2-ip) synaptic terminals upon SDCN neurons, as well as GAD- and/or GlyT2-ip axon terminals in synaptic contact with NK1R-ip SDCN neurons. These results suggested that some synaptic terminals upon NK1R-expressing SDCN neurons co-released both GABA and Gly."}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa_version":"None","month":"11","date_created":"2018-12-11T11:58:54Z","date_updated":"2026-07-29T12:56:27Z","doi":"10.1016/j.neulet.2005.06.068","type":"journal_article","page":"144 - 148","pmid":1,"fulldoi":"https://doi.org/10.1016/j.neulet.2005.06.068","publication_identifier":{"eissn":["1872-7972"],"issn":["0304-3940"]},"citation":{"ama":"Feng Y, Li Y, Wang W, et al. Morphological evidence for GABA/glycine-cocontaining terminals in synaptic contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat. <i>Neuroscience Letters</i>. 2005;388(3):144-148. doi:<a href=\"https://doi.org/10.1016/j.neulet.2005.06.068\">10.1016/j.neulet.2005.06.068</a>","mla":"Feng, Yu, et al. “Morphological Evidence for GABA/Glycine-Cocontaining Terminals in Synaptic Contact with Neurokinin-1 Receptor-Expressing Neurons in the Sacral Dorsal Commissural Nucleus of the Rat.” <i>Neuroscience Letters</i>, vol. 388, no. 3, Elsevier, 2005, pp. 144–48, doi:<a href=\"https://doi.org/10.1016/j.neulet.2005.06.068\">10.1016/j.neulet.2005.06.068</a>.","apa":"Feng, Y., Li, Y., Wang, W., Wu, S., Chen, T., Shigemoto, R., &#38; Mizuno, N. (2005). Morphological evidence for GABA/glycine-cocontaining terminals in synaptic contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat. <i>Neuroscience Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neulet.2005.06.068\">https://doi.org/10.1016/j.neulet.2005.06.068</a>","ieee":"Y. Feng <i>et al.</i>, “Morphological evidence for GABA/glycine-cocontaining terminals in synaptic contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat,” <i>Neuroscience Letters</i>, vol. 388, no. 3. Elsevier, pp. 144–148, 2005.","short":"Y. Feng, Y. Li, W. Wang, S. Wu, T. Chen, R. Shigemoto, N. Mizuno, Neuroscience Letters 388 (2005) 144–148.","ista":"Feng Y, Li Y, Wang W, Wu S, Chen T, Shigemoto R, Mizuno N. 2005. Morphological evidence for GABA/glycine-cocontaining terminals in synaptic contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat. Neuroscience Letters. 388(3), 144–148.","chicago":"Feng, Yu, Yun Li, Wen Wang, Sheng Wu, Tao Chen, Ryuichi Shigemoto, and Noboru Mizuno. “Morphological Evidence for GABA/Glycine-Cocontaining Terminals in Synaptic Contact with Neurokinin-1 Receptor-Expressing Neurons in the Sacral Dorsal Commissural Nucleus of the Rat.” <i>Neuroscience Letters</i>. Elsevier, 2005. <a href=\"https://doi.org/10.1016/j.neulet.2005.06.068\">https://doi.org/10.1016/j.neulet.2005.06.068</a>."},"day":"18","article_type":"original","OA_type":"closed access"},{"publist_id":"4262","publication_status":"published","extern":"1","year":"2003","date_published":"2003-12-19T00:00:00Z","title":"Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology","author":[{"first_name":"Karen","last_name":"Bell","full_name":"Bell, Karen"},{"full_name":"De Kort, G J","first_name":"G J","last_name":"De Kort"},{"full_name":"Steggerda, S","last_name":"Steggerda","first_name":"S"},{"full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi"},{"full_name":"Ribeiro Da Silva, Alfredo","first_name":"Alfredo","last_name":"Ribeiro Da Silva"},{"full_name":"Cuello, Augusto","first_name":"Augusto","last_name":"Cuello"}],"_id":"2637","publisher":"Elsevier","article_processing_charge":"No","issue":"2","external_id":{"pmid":["14664921"]},"quality_controlled":"1","abstract":[{"text":"While the cholinergic depletion in Alzheimer's disease (AD) has been known for some time, a definitive involvement of other neurotransmitter systems has been somewhat more elusive. Our study demonstrates a clear involvement of both glutamatergic and, to a lesser extent, GABAergic neurons in an early onset transgenic mouse model of AD-like amyloid pathology. Immunohistochemical staining and subsequent quantification has revealed a statistically significant increased density of glutamatergic and GABAergic presynaptic boutons in both the plaque free and plaque adjacent cortical neuropile areas of transgenic mice as compared to non-transgenic controls. Furthermore, amyloid plaque size was shown to have a statistically significant effect on the relative area occupied by dystrophic glutamatergic neurites in the peri-plaque neuropile. These findings support our hypothesis that the amyloid pathology progresses in a time and neurotransmitter specific manner, first in the cholinergic system which appears to be most vulnerable, followed by the glutamatergic presynaptic boutons and finally the somewhat more resilient GABAergic terminals.","lang":"eng"}],"status":"public","intvolume":"       353","language":[{"iso":"eng"}],"volume":353,"publication":"Neuroscience Letters","date_created":"2018-12-11T11:58:48Z","doi":"10.1016/j.neulet.2003.09.027","date_updated":"2026-05-22T09:46:51Z","month":"12","oa_version":"None","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","pmid":1,"page":"143 - 147","type":"journal_article","scopus_import":"1","citation":{"ama":"Bell K, De Kort GJ, Steggerda S, Shigemoto R, Ribeiro Da Silva A, Cuello A. Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology. <i>Neuroscience Letters</i>. 2003;353(2):143-147. doi:<a href=\"https://doi.org/10.1016/j.neulet.2003.09.027\">10.1016/j.neulet.2003.09.027</a>","mla":"Bell, Karen, et al. “Structural Involvement of the Glutamatergic Presynaptic Boutons in a Transgenic Mouse Model Expressing Early Onset Amyloid Pathology.” <i>Neuroscience Letters</i>, vol. 353, no. 2, Elsevier, 2003, pp. 143–47, doi:<a href=\"https://doi.org/10.1016/j.neulet.2003.09.027\">10.1016/j.neulet.2003.09.027</a>.","apa":"Bell, K., De Kort, G. J., Steggerda, S., Shigemoto, R., Ribeiro Da Silva, A., &#38; Cuello, A. (2003). Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology. <i>Neuroscience Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neulet.2003.09.027\">https://doi.org/10.1016/j.neulet.2003.09.027</a>","ieee":"K. Bell, G. J. De Kort, S. Steggerda, R. Shigemoto, A. Ribeiro Da Silva, and A. Cuello, “Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology,” <i>Neuroscience Letters</i>, vol. 353, no. 2. Elsevier, pp. 143–147, 2003.","short":"K. Bell, G.J. De Kort, S. Steggerda, R. Shigemoto, A. Ribeiro Da Silva, A. Cuello, Neuroscience Letters 353 (2003) 143–147.","ista":"Bell K, De Kort GJ, Steggerda S, Shigemoto R, Ribeiro Da Silva A, Cuello A. 2003. Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology. Neuroscience Letters. 353(2), 143–147.","chicago":"Bell, Karen, G J De Kort, S Steggerda, Ryuichi Shigemoto, Alfredo Ribeiro Da Silva, and Augusto Cuello. “Structural Involvement of the Glutamatergic Presynaptic Boutons in a Transgenic Mouse Model Expressing Early Onset Amyloid Pathology.” <i>Neuroscience Letters</i>. Elsevier, 2003. <a href=\"https://doi.org/10.1016/j.neulet.2003.09.027\">https://doi.org/10.1016/j.neulet.2003.09.027</a>."},"fulldoi":"https://doi.org/10.1016/j.neulet.2003.09.027","publication_identifier":{"issn":["0304-3940"],"eissn":["1872-7972"]},"article_type":"original","OA_type":"closed access","day":"19"},{"day":"17","article_type":"original","citation":{"ieee":"N. Mizuno, T. Ueyama, K. Itoh, T. Satoda, T. Tashiro, and R. Shigemoto, “Direct projections from the subthalamic nucleus of Luys to the spinal cord in the Japanese monkey,” <i>Neuroscience Letters</i>, vol. 89, no. 1. Elsevier, pp. 13–18, 1988.","mla":"Mizuno, Noboru, et al. “Direct Projections from the Subthalamic Nucleus of Luys to the Spinal Cord in the Japanese Monkey.” <i>Neuroscience Letters</i>, vol. 89, no. 1, Elsevier, 1988, pp. 13–18, doi:<a href=\"https://doi.org/10.1016/0304-3940(88)90473-9\">10.1016/0304-3940(88)90473-9</a>.","apa":"Mizuno, N., Ueyama, T., Itoh, K., Satoda, T., Tashiro, T., &#38; Shigemoto, R. (1988). Direct projections from the subthalamic nucleus of Luys to the spinal cord in the Japanese monkey. <i>Neuroscience Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/0304-3940(88)90473-9\">https://doi.org/10.1016/0304-3940(88)90473-9</a>","ama":"Mizuno N, Ueyama T, Itoh K, Satoda T, Tashiro T, Shigemoto R. Direct projections from the subthalamic nucleus of Luys to the spinal cord in the Japanese monkey. <i>Neuroscience Letters</i>. 1988;89(1):13-18. doi:<a href=\"https://doi.org/10.1016/0304-3940(88)90473-9\">10.1016/0304-3940(88)90473-9</a>","chicago":"Mizuno, Noboru, Teizo Ueyama, Kazuo Itoh, Takahiro Satoda, Takashi Tashiro, and Ryuichi Shigemoto. “Direct Projections from the Subthalamic Nucleus of Luys to the Spinal Cord in the Japanese Monkey.” <i>Neuroscience Letters</i>. Elsevier, 1988. <a href=\"https://doi.org/10.1016/0304-3940(88)90473-9\">https://doi.org/10.1016/0304-3940(88)90473-9</a>.","ista":"Mizuno N, Ueyama T, Itoh K, Satoda T, Tashiro T, Shigemoto R. 1988. Direct projections from the subthalamic nucleus of Luys to the spinal cord in the Japanese monkey. Neuroscience Letters. 89(1), 13–18.","short":"N. Mizuno, T. Ueyama, K. Itoh, T. Satoda, T. Tashiro, R. Shigemoto, Neuroscience Letters 89 (1988) 13–18."},"fulldoi":"https://doi.org/10.1016/0304-3940(88)90473-9","publication_identifier":{"eissn":["1872-7972"],"issn":["0304-3940"]},"scopus_import":"1","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0304394088904739?via%3Dihub"}],"type":"journal_article","page":"13 - 18","pmid":1,"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa_version":"None","month":"06","doi":"10.1016/0304-3940(88)90473-9","date_updated":"2022-02-08T15:20:07Z","date_created":"2018-12-11T11:58:10Z","publication":"Neuroscience Letters","volume":89,"language":[{"iso":"eng"}],"status":"public","intvolume":"        89","acknowledgement":"The photographic help of Mr Akira Uesugi and Mr Kenichl Uesugi, and the support of the Niwa Medical Research Foundation are gratefully acknowledged. This work has also been supported in part by Grants-ln-Aid for General Scientific Research Nos 59480095 and 62480098 from the Ministry of Education, Science and Culture of Japan","abstract":[{"lang":"eng","text":"Injection of large amounts of a mixture of horseradish peroxidase and wheat germ agglutinin-horseradish peroxidase conjugate into the upper cervical segments of the spinal cord in the Japanese monkey (Macaca fuscata) led to the retrograde labeling of a small number of neuronal cell bodies within the rostral part of the subthalamic nucleus of Luys. Direct projection from the subthalamic nucleus to the spinal cord appeared to be much less prominent in the Japanese monkey than in the cat and rat."}],"quality_controlled":"1","external_id":{"pmid":["2456494"]},"issue":"1","publisher":"Elsevier","article_processing_charge":"No","_id":"2523","author":[{"last_name":"Mizuno","first_name":"Noboru","full_name":"Mizuno, Noboru"},{"first_name":"Teizo","last_name":"Ueyama","full_name":"Ueyama, Teizo"},{"full_name":"Itoh, Kazuo","first_name":"Kazuo","last_name":"Itoh"},{"last_name":"Satoda","first_name":"Takahiro","full_name":"Satoda, Takahiro"},{"first_name":"Takashi","last_name":"Tashiro","full_name":"Tashiro, Takashi"},{"full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto"}],"title":"Direct projections from the subthalamic nucleus of Luys to the spinal cord in the Japanese monkey","date_published":"1988-06-17T00:00:00Z","year":"1988","publication_status":"published","extern":"1","publist_id":"4377"}]