---
OA_type: closed access
_id: '2637'
abstract:
- lang: eng
  text: While the cholinergic depletion in Alzheimer's disease (AD) has been known
    for some time, a definitive involvement of other neurotransmitter systems has
    been somewhat more elusive. Our study demonstrates a clear involvement of both
    glutamatergic and, to a lesser extent, GABAergic neurons in an early onset transgenic
    mouse model of AD-like amyloid pathology. Immunohistochemical staining and subsequent
    quantification has revealed a statistically significant increased density of glutamatergic
    and GABAergic presynaptic boutons in both the plaque free and plaque adjacent
    cortical neuropile areas of transgenic mice as compared to non-transgenic controls.
    Furthermore, amyloid plaque size was shown to have a statistically significant
    effect on the relative area occupied by dystrophic glutamatergic neurites in the
    peri-plaque neuropile. These findings support our hypothesis that the amyloid
    pathology progresses in a time and neurotransmitter specific manner, first in
    the cholinergic system which appears to be most vulnerable, followed by the glutamatergic
    presynaptic boutons and finally the somewhat more resilient GABAergic terminals.
article_processing_charge: No
article_type: original
author:
- first_name: Karen
  full_name: Bell, Karen
  last_name: Bell
- first_name: G J
  full_name: De Kort, G J
  last_name: De Kort
- first_name: S
  full_name: Steggerda, S
  last_name: Steggerda
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Alfredo
  full_name: Ribeiro Da Silva, Alfredo
  last_name: Ribeiro Da Silva
- first_name: Augusto
  full_name: Cuello, Augusto
  last_name: Cuello
citation:
  ama: Bell K, De Kort GJ, Steggerda S, Shigemoto R, Ribeiro Da Silva A, Cuello A.
    Structural involvement of the glutamatergic presynaptic boutons in a transgenic
    mouse model expressing early onset amyloid pathology. <i>Neuroscience Letters</i>.
    2003;353(2):143-147. doi:<a href="https://doi.org/10.1016/j.neulet.2003.09.027">10.1016/j.neulet.2003.09.027</a>
  apa: Bell, K., De Kort, G. J., Steggerda, S., Shigemoto, R., Ribeiro Da Silva, A.,
    &#38; Cuello, A. (2003). Structural involvement of the glutamatergic presynaptic
    boutons in a transgenic mouse model expressing early onset amyloid pathology.
    <i>Neuroscience Letters</i>. Elsevier. <a href="https://doi.org/10.1016/j.neulet.2003.09.027">https://doi.org/10.1016/j.neulet.2003.09.027</a>
  chicago: Bell, Karen, G J De Kort, S Steggerda, Ryuichi Shigemoto, Alfredo Ribeiro
    Da Silva, and Augusto Cuello. “Structural Involvement of the Glutamatergic Presynaptic
    Boutons in a Transgenic Mouse Model Expressing Early Onset Amyloid Pathology.”
    <i>Neuroscience Letters</i>. Elsevier, 2003. <a href="https://doi.org/10.1016/j.neulet.2003.09.027">https://doi.org/10.1016/j.neulet.2003.09.027</a>.
  ieee: K. Bell, G. J. De Kort, S. Steggerda, R. Shigemoto, A. Ribeiro Da Silva, and
    A. Cuello, “Structural involvement of the glutamatergic presynaptic boutons in
    a transgenic mouse model expressing early onset amyloid pathology,” <i>Neuroscience
    Letters</i>, vol. 353, no. 2. Elsevier, pp. 143–147, 2003.
  ista: Bell K, De Kort GJ, Steggerda S, Shigemoto R, Ribeiro Da Silva A, Cuello A.
    2003. Structural involvement of the glutamatergic presynaptic boutons in a transgenic
    mouse model expressing early onset amyloid pathology. Neuroscience Letters. 353(2),
    143–147.
  mla: Bell, Karen, et al. “Structural Involvement of the Glutamatergic Presynaptic
    Boutons in a Transgenic Mouse Model Expressing Early Onset Amyloid Pathology.”
    <i>Neuroscience Letters</i>, vol. 353, no. 2, Elsevier, 2003, pp. 143–47, doi:<a
    href="https://doi.org/10.1016/j.neulet.2003.09.027">10.1016/j.neulet.2003.09.027</a>.
  short: K. Bell, G.J. De Kort, S. Steggerda, R. Shigemoto, A. Ribeiro Da Silva, A.
    Cuello, Neuroscience Letters 353 (2003) 143–147.
date_created: 2018-12-11T11:58:48Z
date_published: 2003-12-19T00:00:00Z
date_updated: 2026-05-22T09:46:51Z
day: '19'
doi: 10.1016/j.neulet.2003.09.027
extern: '1'
external_id:
  pmid:
  - '14664921'
intvolume: '       353'
issue: '2'
language:
- iso: eng
month: '12'
oa_version: None
page: 143 - 147
pmid: 1
publication: Neuroscience Letters
publication_identifier:
  eissn:
  - 1872-7972
  issn:
  - 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4262'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Structural involvement of the glutamatergic presynaptic boutons in a transgenic
  mouse model expressing early onset amyloid pathology
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 353
year: '2003'
...
---
_id: '2523'
abstract:
- lang: eng
  text: Injection of large amounts of a mixture of horseradish peroxidase and wheat
    germ agglutinin-horseradish peroxidase conjugate into the upper cervical segments
    of the spinal cord in the Japanese monkey (Macaca fuscata) led to the retrograde
    labeling of a small number of neuronal cell bodies within the rostral part of
    the subthalamic nucleus of Luys. Direct projection from the subthalamic nucleus
    to the spinal cord appeared to be much less prominent in the Japanese monkey than
    in the cat and rat.
acknowledgement: The photographic help of Mr Akira Uesugi and Mr Kenichl Uesugi, and
  the support of the Niwa Medical Research Foundation are gratefully acknowledged.
  This work has also been supported in part by Grants-ln-Aid for General Scientific
  Research Nos 59480095 and 62480098 from the Ministry of Education, Science and Culture
  of Japan
article_processing_charge: No
article_type: original
author:
- first_name: Noboru
  full_name: Mizuno, Noboru
  last_name: Mizuno
- first_name: Teizo
  full_name: Ueyama, Teizo
  last_name: Ueyama
- first_name: Kazuo
  full_name: Itoh, Kazuo
  last_name: Itoh
- first_name: Takahiro
  full_name: Satoda, Takahiro
  last_name: Satoda
- first_name: Takashi
  full_name: Tashiro, Takashi
  last_name: Tashiro
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
citation:
  ama: Mizuno N, Ueyama T, Itoh K, Satoda T, Tashiro T, Shigemoto R. Direct projections
    from the subthalamic nucleus of Luys to the spinal cord in the Japanese monkey.
    <i>Neuroscience Letters</i>. 1988;89(1):13-18. doi:<a href="https://doi.org/10.1016/0304-3940(88)90473-9">10.1016/0304-3940(88)90473-9</a>
  apa: Mizuno, N., Ueyama, T., Itoh, K., Satoda, T., Tashiro, T., &#38; Shigemoto,
    R. (1988). Direct projections from the subthalamic nucleus of Luys to the spinal
    cord in the Japanese monkey. <i>Neuroscience Letters</i>. Elsevier. <a href="https://doi.org/10.1016/0304-3940(88)90473-9">https://doi.org/10.1016/0304-3940(88)90473-9</a>
  chicago: Mizuno, Noboru, Teizo Ueyama, Kazuo Itoh, Takahiro Satoda, Takashi Tashiro,
    and Ryuichi Shigemoto. “Direct Projections from the Subthalamic Nucleus of Luys
    to the Spinal Cord in the Japanese Monkey.” <i>Neuroscience Letters</i>. Elsevier,
    1988. <a href="https://doi.org/10.1016/0304-3940(88)90473-9">https://doi.org/10.1016/0304-3940(88)90473-9</a>.
  ieee: N. Mizuno, T. Ueyama, K. Itoh, T. Satoda, T. Tashiro, and R. Shigemoto, “Direct
    projections from the subthalamic nucleus of Luys to the spinal cord in the Japanese
    monkey,” <i>Neuroscience Letters</i>, vol. 89, no. 1. Elsevier, pp. 13–18, 1988.
  ista: Mizuno N, Ueyama T, Itoh K, Satoda T, Tashiro T, Shigemoto R. 1988. Direct
    projections from the subthalamic nucleus of Luys to the spinal cord in the Japanese
    monkey. Neuroscience Letters. 89(1), 13–18.
  mla: Mizuno, Noboru, et al. “Direct Projections from the Subthalamic Nucleus of
    Luys to the Spinal Cord in the Japanese Monkey.” <i>Neuroscience Letters</i>,
    vol. 89, no. 1, Elsevier, 1988, pp. 13–18, doi:<a href="https://doi.org/10.1016/0304-3940(88)90473-9">10.1016/0304-3940(88)90473-9</a>.
  short: N. Mizuno, T. Ueyama, K. Itoh, T. Satoda, T. Tashiro, R. Shigemoto, Neuroscience
    Letters 89 (1988) 13–18.
date_created: 2018-12-11T11:58:10Z
date_published: 1988-06-17T00:00:00Z
date_updated: 2022-02-08T15:20:07Z
day: '17'
doi: 10.1016/0304-3940(88)90473-9
extern: '1'
external_id:
  pmid:
  - '2456494'
intvolume: '        89'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0304394088904739?via%3Dihub
month: '06'
oa_version: None
page: 13 - 18
pmid: 1
publication: Neuroscience Letters
publication_identifier:
  eissn:
  - 1872-7972
  issn:
  - 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4377'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Direct projections from the subthalamic nucleus of Luys to the spinal cord
  in the Japanese monkey
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 89
year: '1988'
...