---
_id: '14080'
abstract:
- lang: eng
text: Extracellular signal-regulated kinase (ERK) has been recognized as a critical
regulator in various physiological and pathological processes. Extensive research
has elucidated the signaling mechanisms governing ERK activation via biochemical
regulations with upstream molecules, particularly receptor tyrosine kinases (RTKs).
However, recent advances have highlighted the role of mechanical forces in activating
the RTK–ERK signaling pathways, thereby opening new avenues of research into mechanochemical
interplay in multicellular tissues. Here, we review the force-induced ERK activation
in cells and propose possible mechanosensing mechanisms underlying the mechanoresponsive
ERK activation. We conclude that mechanical forces are not merely passive factors
shaping cells and tissues but also active regulators of cellular signaling pathways
controlling collective cell behaviors.
acknowledgement: TH was supported by JSPS KAKENHI Grant (no. 21H05290) and the Ministry
of Education under the Research Centres of Excellence programme through the Mechanobiology
Institute at National University of Singapore and by Department of Physiology at
National University of Singapore. NH was supported by JSPS KAKENHI Grant (no. 20K22653).
KA was supported by JSPS KAKENHI Grants (no. 19H05798 and no. 22H02625). MM was
supported by JSPS KAKENHI Grants (no. 19H00993 and no. 20H05898) and JST Moonshot
R&D Grant JPMJPS2022. We appreciate Virgile Viasnoff and the lab members for their
valuable comments on the manuscript. We apologize to authors whose work could not
be highlighted due to space limitations.
article_number: '102217'
article_processing_charge: Yes (in subscription journal)
article_type: review
author:
- first_name: Tsuyoshi
full_name: Hirashima, Tsuyoshi
last_name: Hirashima
- first_name: Naoya
full_name: Hino, Naoya
id: 5299a9ce-7679-11eb-a7bc-d1e62b936307
last_name: Hino
- first_name: Kazuhiro
full_name: Aoki, Kazuhiro
last_name: Aoki
- first_name: Michiyuki
full_name: Matsuda, Michiyuki
last_name: Matsuda
citation:
ama: Hirashima T, Hino N, Aoki K, Matsuda M. Stretching the limits of extracellular
signal-related kinase (ERK) signaling — Cell mechanosensing to ERK activation.
Current Opinion in Cell Biology. 2023;84(10). doi:10.1016/j.ceb.2023.102217
apa: Hirashima, T., Hino, N., Aoki, K., & Matsuda, M. (2023). Stretching the
limits of extracellular signal-related kinase (ERK) signaling — Cell mechanosensing
to ERK activation. Current Opinion in Cell Biology. Elsevier. https://doi.org/10.1016/j.ceb.2023.102217
chicago: Hirashima, Tsuyoshi, Naoya Hino, Kazuhiro Aoki, and Michiyuki Matsuda.
“Stretching the Limits of Extracellular Signal-Related Kinase (ERK) Signaling
— Cell Mechanosensing to ERK Activation.” Current Opinion in Cell Biology.
Elsevier, 2023. https://doi.org/10.1016/j.ceb.2023.102217.
ieee: T. Hirashima, N. Hino, K. Aoki, and M. Matsuda, “Stretching the limits of
extracellular signal-related kinase (ERK) signaling — Cell mechanosensing to ERK
activation,” Current Opinion in Cell Biology, vol. 84, no. 10. Elsevier,
2023.
ista: Hirashima T, Hino N, Aoki K, Matsuda M. 2023. Stretching the limits of extracellular
signal-related kinase (ERK) signaling — Cell mechanosensing to ERK activation.
Current Opinion in Cell Biology. 84(10), 102217.
mla: Hirashima, Tsuyoshi, et al. “Stretching the Limits of Extracellular Signal-Related
Kinase (ERK) Signaling — Cell Mechanosensing to ERK Activation.” Current Opinion
in Cell Biology, vol. 84, no. 10, 102217, Elsevier, 2023, doi:10.1016/j.ceb.2023.102217.
short: T. Hirashima, N. Hino, K. Aoki, M. Matsuda, Current Opinion in Cell Biology
84 (2023).
date_created: 2023-08-20T22:01:12Z
date_published: 2023-10-01T00:00:00Z
date_updated: 2024-01-30T12:52:42Z
day: '01'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.1016/j.ceb.2023.102217
external_id:
isi:
- '001054692200001'
pmid:
- '37574635'
file:
- access_level: open_access
checksum: 25923f8ae71344e8974530dd23c71bdc
content_type: application/pdf
creator: dernst
date_created: 2024-01-30T12:52:12Z
date_updated: 2024-01-30T12:52:12Z
file_id: '14909'
file_name: 2023_CurrentOpinionCellBio_Hirashima.pdf
file_size: 1173762
relation: main_file
success: 1
file_date_updated: 2024-01-30T12:52:12Z
has_accepted_license: '1'
intvolume: ' 84'
isi: 1
issue: '10'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
publication: Current Opinion in Cell Biology
publication_identifier:
eissn:
- 1879-0410
issn:
- 0955-0674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Stretching the limits of extracellular signal-related kinase (ERK) signaling
— Cell mechanosensing to ERK activation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 84
year: '2023'
...
---
_id: '6559'
abstract:
- lang: eng
text: Branching morphogenesis is a prototypical example of complex three-dimensional
organ sculpting, required in multiple developmental settings to maximize the area
of exchange surfaces. It requires, in particular, the coordinated growth of different
cell types together with complex patterning to lead to robust macroscopic outputs.
In recent years, novel multiscale quantitative biology approaches, together with
biophysical modelling, have begun to shed new light of this topic. Here, we wish
to review some of these recent developments, highlighting the generic design principles
that can be abstracted across different branched organs, as well as the implications
for the broader fields of stem cell, developmental and systems biology.
article_processing_charge: No
article_type: original
author:
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Benjamin D.
full_name: Simons, Benjamin D.
last_name: Simons
citation:
ama: Hannezo EB, Simons BD. Multiscale dynamics of branching morphogenesis. Current
Opinion in Cell Biology. 2019;60:99-105. doi:10.1016/j.ceb.2019.04.008
apa: Hannezo, E. B., & Simons, B. D. (2019). Multiscale dynamics of branching
morphogenesis. Current Opinion in Cell Biology. Elsevier. https://doi.org/10.1016/j.ceb.2019.04.008
chicago: Hannezo, Edouard B, and Benjamin D. Simons. “Multiscale Dynamics of Branching
Morphogenesis.” Current Opinion in Cell Biology. Elsevier, 2019. https://doi.org/10.1016/j.ceb.2019.04.008.
ieee: E. B. Hannezo and B. D. Simons, “Multiscale dynamics of branching morphogenesis,”
Current Opinion in Cell Biology, vol. 60. Elsevier, pp. 99–105, 2019.
ista: Hannezo EB, Simons BD. 2019. Multiscale dynamics of branching morphogenesis.
Current Opinion in Cell Biology. 60, 99–105.
mla: Hannezo, Edouard B., and Benjamin D. Simons. “Multiscale Dynamics of Branching
Morphogenesis.” Current Opinion in Cell Biology, vol. 60, Elsevier, 2019,
pp. 99–105, doi:10.1016/j.ceb.2019.04.008.
short: E.B. Hannezo, B.D. Simons, Current Opinion in Cell Biology 60 (2019) 99–105.
date_created: 2019-06-16T21:59:12Z
date_published: 2019-10-01T00:00:00Z
date_updated: 2026-04-03T09:38:46Z
day: '01'
department:
- _id: EdHa
doi: 10.1016/j.ceb.2019.04.008
external_id:
isi:
- '000486545800014'
pmid:
- '31181348'
intvolume: ' 60'
isi: 1
language:
- iso: eng
month: '10'
oa_version: None
page: 99-105
pmid: 1
publication: Current Opinion in Cell Biology
publication_identifier:
eissn:
- 1879-0410
issn:
- 0955-0674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Multiscale dynamics of branching morphogenesis
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 60
year: '2019'
...