---
OA_type: closed access
_id: '3728'
abstract:
- lang: eng
  text: Mechanical unfolding of single bacteriorhodopsins from a membrane bilayer
    is studied using molecular dynamics simulations. The initial conformation of the
    lipid membrane is determined through all-atom simulations and then its coarse-grained
    representation is used in the studies of stretching. A Go-like model with a realistic
    contact map and with Lennard–Jones contact interactions is applied to model the
    protein–membrane system. The model qualitatively reproduces the experimentally
    observed differences between force-extension patterns obtained on bacteriorhodopsin
    at different temperatures and predicts a lack of symmetry in the choice of the
    terminus to pull by. It also illustrates the decisive role of the interactions
    of the protein with the membrane in determining the force pattern and thus the
    stability of transmembrane proteins.
article_processing_charge: No
article_type: original
author:
- first_name: Marek
  full_name: Cieplak, Marek
  last_name: Cieplak
- first_name: Sławomir
  full_name: Filipek, Sławomir
  last_name: Filipek
- first_name: Harald L
  full_name: Janovjak, Harald L
  id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
  last_name: Janovjak
  orcid: 0000-0002-8023-9315
- first_name: Krystiana
  full_name: Krzysko, Krystiana
  last_name: Krzysko
citation:
  ama: 'Cieplak M, Filipek S, Janovjak HL, Krzysko K. Pulling single bacteriorhodopsin
    out of a membrane: Comparison of simulation and experiment. <i>Biochimica et Biophysica
    Acta (BBA) - Biomembranes</i>. 2006;1758(4):537-544. doi:<a href="https://doi.org/10.1016/j.bbamem.2006.03.028">10.1016/j.bbamem.2006.03.028</a>'
  apa: 'Cieplak, M., Filipek, S., Janovjak, H. L., &#38; Krzysko, K. (2006). Pulling
    single bacteriorhodopsin out of a membrane: Comparison of simulation and experiment.
    <i>Biochimica et Biophysica Acta (BBA) - Biomembranes</i>. Elsevier. <a href="https://doi.org/10.1016/j.bbamem.2006.03.028">https://doi.org/10.1016/j.bbamem.2006.03.028</a>'
  chicago: 'Cieplak, Marek, Sławomir Filipek, Harald L Janovjak, and Krystiana Krzysko.
    “Pulling Single Bacteriorhodopsin out of a Membrane: Comparison of Simulation
    and Experiment.” <i>Biochimica et Biophysica Acta (BBA) - Biomembranes</i>. Elsevier,
    2006. <a href="https://doi.org/10.1016/j.bbamem.2006.03.028">https://doi.org/10.1016/j.bbamem.2006.03.028</a>.'
  ieee: 'M. Cieplak, S. Filipek, H. L. Janovjak, and K. Krzysko, “Pulling single bacteriorhodopsin
    out of a membrane: Comparison of simulation and experiment,” <i>Biochimica et
    Biophysica Acta (BBA) - Biomembranes</i>, vol. 1758, no. 4. Elsevier, pp. 537–544,
    2006.'
  ista: 'Cieplak M, Filipek S, Janovjak HL, Krzysko K. 2006. Pulling single bacteriorhodopsin
    out of a membrane: Comparison of simulation and experiment. Biochimica et Biophysica
    Acta (BBA) - Biomembranes. 1758(4), 537–544.'
  mla: 'Cieplak, Marek, et al. “Pulling Single Bacteriorhodopsin out of a Membrane:
    Comparison of Simulation and Experiment.” <i>Biochimica et Biophysica Acta (BBA)
    - Biomembranes</i>, vol. 1758, no. 4, Elsevier, 2006, pp. 537–44, doi:<a href="https://doi.org/10.1016/j.bbamem.2006.03.028">10.1016/j.bbamem.2006.03.028</a>.'
  short: M. Cieplak, S. Filipek, H.L. Janovjak, K. Krzysko, Biochimica et Biophysica
    Acta (BBA) - Biomembranes 1758 (2006) 537–544.
date_created: 2018-12-11T12:04:50Z
date_published: 2006-04-01T00:00:00Z
date_updated: 2026-08-27T10:58:08Z
day: '01'
doi: 10.1016/j.bbamem.2006.03.028
extern: '1'
external_id:
  pmid:
  - '16678120'
fulldoi: https://doi.org/10.1016/j.bbamem.2006.03.028
intvolume: '      1758'
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
page: 537 - 544
pmid: 1
publication: Biochimica et Biophysica Acta (BBA) - Biomembranes
publication_identifier:
  eissn:
  - 1879-2642
  issn:
  - 0005-2736
publication_status: published
publisher: Elsevier
publist_id: '2502'
status: public
title: 'Pulling single bacteriorhodopsin out of a membrane: Comparison of simulation
  and experiment'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 1758
year: '2006'
...