[{"external_id":{"pmid":["41455723"]},"language":[{"iso":"eng"}],"PlanS_conform":"1","status":"public","publication_identifier":{"eissn":["2041-1723"]},"intvolume":"        17","article_number":"999","oa":1,"date_updated":"2026-02-12T14:34:24Z","date_created":"2026-02-08T23:02:48Z","DOAJ_listed":"1","citation":{"ama":"Yang P, Liu Y, Dong Q, et al. O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering. <i>Nature Communications</i>. 2026;17. doi:<a href=\"https://doi.org/10.1038/s41467-025-67734-0\">10.1038/s41467-025-67734-0</a>","mla":"Yang, Pengfang, et al. “O-GlcNAc and Phosphorylation Modifications on HtL1/FBA10 Regulate Wheat Vernalization for Flowering.” <i>Nature Communications</i>, vol. 17, 999, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41467-025-67734-0\">10.1038/s41467-025-67734-0</a>.","ieee":"P. Yang <i>et al.</i>, “O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering,” <i>Nature Communications</i>, vol. 17. Springer Nature, 2026.","apa":"Yang, P., Liu, Y., Dong, Q., Miao, Y., Zhang, J., Xu, S., … Chong, K. (2026). O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-67734-0\">https://doi.org/10.1038/s41467-025-67734-0</a>","chicago":"Yang, Pengfang, Yangyang Liu, Qi Dong, Yuting Miao, Jianlong Zhang, Shujuan Xu, Hong Zhao, et al. “O-GlcNAc and Phosphorylation Modifications on HtL1/FBA10 Regulate Wheat Vernalization for Flowering.” <i>Nature Communications</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41467-025-67734-0\">https://doi.org/10.1038/s41467-025-67734-0</a>.","short":"P. Yang, Y. Liu, Q. Dong, Y. Miao, J. Zhang, S. Xu, H. Zhao, Y. Niu, X. Zhang, Y. Xu, Z. Guo, L. Xing, K. Chong, Nature Communications 17 (2026).","ista":"Yang P, Liu Y, Dong Q, Miao Y, Zhang J, Xu S, Zhao H, Niu Y, Zhang X, Xu Y, Guo Z, Xing L, Chong K. 2026. O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering. Nature Communications. 17, 999."},"article_processing_charge":"Yes","_id":"21158","date_published":"2026-01-27T00:00:00Z","year":"2026","article_type":"original","author":[{"first_name":"Pengfang","last_name":"Yang","full_name":"Yang, Pengfang"},{"first_name":"Yangyang","last_name":"Liu","full_name":"Liu, Yangyang"},{"full_name":"Dong, Qi","last_name":"Dong","first_name":"Qi"},{"first_name":"Yuting","last_name":"Miao","full_name":"Miao, Yuting"},{"full_name":"Zhang, Jianlong","last_name":"Zhang","first_name":"Jianlong"},{"first_name":"Shujuan","id":"9724dd9d-f591-11ee-bd51-e97ed0652286","last_name":"Xu","full_name":"Xu, Shujuan"},{"full_name":"Zhao, Hong","last_name":"Zhao","first_name":"Hong"},{"last_name":"Niu","first_name":"Yuda","full_name":"Niu, Yuda"},{"last_name":"Zhang","first_name":"Xueyong","full_name":"Zhang, Xueyong"},{"full_name":"Xu, Yunyuan","first_name":"Yunyuan","last_name":"Xu"},{"first_name":"Zifeng","last_name":"Guo","full_name":"Guo, Zifeng"},{"full_name":"Xing, Lijing","last_name":"Xing","first_name":"Lijing"},{"last_name":"Chong","first_name":"Kang","full_name":"Chong, Kang"}],"oa_version":"Published Version","month":"01","publisher":"Springer Nature","abstract":[{"text":"Vernalization-regulated flowering is vital for wheat yield and geographical distribution, and the diversity of flowering time genes is essential for the breeding of climate-resilient varieties. Sugars have long been recognized in regulating flowering; however, the intrinsic connection between carbohydrate metabolism and vernalization response remains largely unexplored. Here, we identify a fructose 1,6-bisphosphate aldolase (FBA) encoding gene, HtL1/FBA10, as a modulator of heading time variation based on a genome-wide association study utilizing wheat core germplasm collections. Evolutionary analysis shows a decrease in the proportion of haplotype-2 of HtL1, which is linked to delayed flowering, in Chinese and American wheat varieties compared to landraces. Vernalization reduces HtL1/FBA10 phosphorylation levels and  increases  its O-GlcNAcylation, which in turn enhances its enzymatic activity and facilitates VERNALIZATION 1 (VRN1) transcription by regulating histone acetylation at the VRN1 locus. Our findings provide mechanistic insights into the interplay between glucose metabolism and the epigenetic regulation of vernalization in winter wheat.","lang":"eng"}],"has_accepted_license":"1","type":"journal_article","quality_controlled":"1","scopus_import":"1","volume":17,"department":[{"_id":"XiFe"}],"OA_place":"publisher","license":"https://creativecommons.org/licenses/by/4.0/","file":[{"creator":"dernst","success":1,"date_created":"2026-02-12T14:33:14Z","file_name":"2026_NatureComm_Yang.pdf","checksum":"9ae170ec70ba1ab56b6f1ffe67d1de7f","date_updated":"2026-02-12T14:33:14Z","content_type":"application/pdf","access_level":"open_access","file_size":4685882,"file_id":"21223","relation":"main_file"}],"doi":"10.1038/s41467-025-67734-0","file_date_updated":"2026-02-12T14:33:14Z","pmid":1,"OA_type":"gold","acknowledgement":"This work was supported by the Basic Science Center Project of National Natural Science Foundation of China (32388201) to K.C and the National Natural Science Foundation of China (31970331) to L.X. We thank Dr. Zhuang Lu, Dr. Bin Han and Ms. Jingquan Li (Plant Science Facility of the Institute of Botany, Chinese Academy of Sciences) for their technical assistance in LC-MS/MS assay, small molecule compound analysis and the subcellular localization assay, respectively. We thank Dr. Wei Luo and Dr. Dongfeng Liu for helpful discussions.","day":"27","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_status":"published","ddc":["580"],"publication":"Nature Communications","title":"O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering"},{"external_id":{"pmid":["41708600"]},"language":[{"iso":"eng"}],"PlanS_conform":"1","publication_identifier":{"eissn":["2041-1723"]},"status":"public","project":[{"call_identifier":"H2020","_id":"eba2549b-77a9-11ec-83b8-a81e493eae4e","grant_number":"802960","name":"Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines"}],"article_number":"1933","intvolume":"        17","DOAJ_listed":"1","oa":1,"date_created":"2026-03-01T23:01:38Z","date_updated":"2026-03-02T09:36:48Z","_id":"21369","date_published":"2026-02-20T00:00:00Z","article_processing_charge":"Yes","citation":{"apa":"Hu, J., Scheidt, T., Thacker, D., Axell, E., Stemme, E., Łapińska, U., … Dear, A. J. (2026). Structural defects in amyloid-β fibrils drive secondary nucleation. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-026-69377-1\">https://doi.org/10.1038/s41467-026-69377-1</a>","chicago":"Hu, Jing, Tom Scheidt, Dev Thacker, Emil Axell, Elin Stemme, Urszula Łapińska, Stefan Wennmalm, et al. “Structural Defects in Amyloid-β Fibrils Drive Secondary Nucleation.” <i>Nature Communications</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41467-026-69377-1\">https://doi.org/10.1038/s41467-026-69377-1</a>.","ama":"Hu J, Scheidt T, Thacker D, et al. Structural defects in amyloid-β fibrils drive secondary nucleation. <i>Nature Communications</i>. 2026;17. doi:<a href=\"https://doi.org/10.1038/s41467-026-69377-1\">10.1038/s41467-026-69377-1</a>","ieee":"J. Hu <i>et al.</i>, “Structural defects in amyloid-β fibrils drive secondary nucleation,” <i>Nature Communications</i>, vol. 17. Springer Nature, 2026.","mla":"Hu, Jing, et al. “Structural Defects in Amyloid-β Fibrils Drive Secondary Nucleation.” <i>Nature Communications</i>, vol. 17, 1933, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41467-026-69377-1\">10.1038/s41467-026-69377-1</a>.","ista":"Hu J, Scheidt T, Thacker D, Axell E, Stemme E, Łapińska U, Wennmalm S, Meisl G, Curk S, Andreasen M, Vendruscolo M, Arosio P, Šarić A, Schmit JD, Knowles TPJ, Sparr E, Linse S, Michaels TCT, Dear AJ. 2026. Structural defects in amyloid-β fibrils drive secondary nucleation. Nature Communications. 17, 1933.","short":"J. Hu, T. Scheidt, D. Thacker, E. Axell, E. Stemme, U. Łapińska, S. Wennmalm, G. Meisl, S. Curk, M. Andreasen, M. Vendruscolo, P. Arosio, A. Šarić, J.D. Schmit, T.P.J. Knowles, E. Sparr, S. Linse, T.C.T. Michaels, A.J. Dear, Nature Communications 17 (2026)."},"article_type":"original","year":"2026","oa_version":"Published Version","publisher":"Springer Nature","month":"02","author":[{"full_name":"Hu, Jing","first_name":"Jing","last_name":"Hu"},{"full_name":"Scheidt, Tom","first_name":"Tom","last_name":"Scheidt"},{"last_name":"Thacker","first_name":"Dev","full_name":"Thacker, Dev"},{"full_name":"Axell, Emil","last_name":"Axell","first_name":"Emil"},{"last_name":"Stemme","first_name":"Elin","full_name":"Stemme, Elin"},{"full_name":"Łapińska, Urszula","first_name":"Urszula","last_name":"Łapińska"},{"full_name":"Wennmalm, Stefan","first_name":"Stefan","last_name":"Wennmalm"},{"last_name":"Meisl","first_name":"Georg","full_name":"Meisl, Georg"},{"orcid":"0000-0001-6160-9766","full_name":"Curk, Samo","first_name":"Samo","id":"031eff0d-d481-11ee-8508-cd12a7a86e5b","last_name":"Curk"},{"first_name":"Maria","last_name":"Andreasen","full_name":"Andreasen, Maria"},{"last_name":"Vendruscolo","first_name":"Michele","full_name":"Vendruscolo, Michele"},{"first_name":"Paolo","last_name":"Arosio","full_name":"Arosio, Paolo"},{"first_name":"Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","last_name":"Šarić","orcid":"0000-0002-7854-2139","full_name":"Šarić, Anđela"},{"full_name":"Schmit, Jeremy D.","last_name":"Schmit","first_name":"Jeremy D."},{"full_name":"Knowles, Tuomas P.J.","first_name":"Tuomas P.J.","last_name":"Knowles"},{"first_name":"Emma","last_name":"Sparr","full_name":"Sparr, Emma"},{"full_name":"Linse, Sara","first_name":"Sara","last_name":"Linse"},{"full_name":"Michaels, Thomas C.T.","last_name":"Michaels","first_name":"Thomas C.T."},{"last_name":"Dear","first_name":"Alexander J.","full_name":"Dear, Alexander J."}],"abstract":[{"lang":"eng","text":"Formation of new amyloid fibrils and oligomers from monomeric protein on the surfaces of existing fibrils is an important driver of many disorders such as Alzheimer’s and Parkinson’s diseases. The structural basis of this secondary nucleation process, however, is poorly understood. Here, we ask whether secondary nucleation sites are found predominantly at rare growth defects: irregularities in the fibril core structure incorporated during their original assembly. We first demonstrate using the specific inhibitor of secondary nucleation, Brichos, that secondary nucleation sites on Alzheimer’s disease-associated fibrils composed of Aβ40 and Aβ42 peptides are rare compared to the number of protein molecules they contain. We then grow Aβ40 fibrils under conditions designed to eliminate most growth defects while leaving the regular fibril morphology unchanged, and confirm the latter using cryo-electron microscopy. We measure both the ability of these annealed fibrils to promote secondary nucleation and the stoichiometry of their secondary nucleation sites, finding that both are greatly reduced as predicted. Re-analysis of published data for other proteins suggests that fibril growth defects may also drive secondary nucleation generally across most amyloids. These findings could unlock structure-based drug design of therapeutics that aim to halt amyloid disorders by inhibiting secondary nucleation sites."}],"has_accepted_license":"1","volume":17,"type":"journal_article","quality_controlled":"1","scopus_import":"1","ec_funded":1,"file":[{"file_id":"21377","relation":"main_file","file_size":4821073,"content_type":"application/pdf","checksum":"fa2b55b3a0d8978de7d2d061c7ad8779","file_name":"2026_NatureComm_Hu.pdf","date_created":"2026-03-02T09:34:18Z","date_updated":"2026-03-02T09:34:18Z","access_level":"open_access","success":1,"creator":"dernst"}],"OA_place":"publisher","department":[{"_id":"AnSa"}],"pmid":1,"OA_type":"gold","file_date_updated":"2026-03-02T09:34:18Z","doi":"10.1038/s41467-026-69377-1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_status":"published","day":"20","acknowledgement":"This work was supported by the Swedish Research Council (2019-02397 to E.S., 2015-00143 to S.L., and 2022-06641 to S.L. and E.S.), and the GenerationNano project, the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 945378 (S.L. co-PI). We acknowledge support from the Wellcome Trust (T.P.J.K.), the Cambridge Centre for Misfolding Diseases (T.P.J.K.), the BBSRC (T.P.J.K.), the Frances and Augustus Newman Foundation (T.P.J.K.), the ERC PhysProt (agreement n 337969) (T.S., T.P.J.K., S.L.), ETC StG “NEPA” (A.Š. and S.C.), the Royal Society (S.C., A.S.), the ERASMUS Programme (T.S.), and The Danish Council for Independent Research ∣ Natural Sciences (FNU-11-113326) (M.A.). This work was also funded by the Novo Nordisk Foundation (#NNF19OC0054635 to S.L.), ETH Zürich (T.C.T.M.), and the Swiss National Science Foundation (grant no 219703 to A.J.D. and T.C.T.M.). We acknowledge the use of the nano-Characterisation and nano-Manufacturing Research Equipment (nCHREM) facility for access to microscopy instrumentation. We are grateful to the late Professor Sir Christopher Dobson for invaluable conversations regarding the microfluidic diffusional sizing experiments. We are also grateful to Quentin A. E. Peter and Thomas Müller for their guidance on microfluidic device design. The cuvette-filled icon in Fig. 3d is by Servier [https://smart.servier.com/]. It is licensed under CC-BY 3.0 Unported [https://creativecommons.org/licenses/by/3.0/]. The authors would like to acknowledge Umeå Centre for Electron Microscopy (UCEM) for technical assistance and access to electron microscopy. Support was provided by SciLifeLab national Cryo-EM Unit at Umeå University.","ddc":["570"],"title":"Structural defects in amyloid-β fibrils drive secondary nucleation","publication":"Nature Communications"},{"corr_author":"1","has_accepted_license":"1","abstract":[{"lang":"eng","text":"The exceptional energy-harvesting efficiency of lead-halide perovskites arises from unusually long photocarrier diffusion lengths and recombination lifetimes that persist even in defect-rich, solution-grown samples. Paradoxically, perovskites are also known for having very short exciton decay times. Here, we resolve this apparent contradiction by showing that key optoelectronic properties of perovskites can be explained by localized flexoelectric polarization confined to interfaces between domains of spontaneous strain. Using birefringence imaging, electrochemical staining, and zero-bias photocurrent measurements, we visualize the domain structure and directly probe the associated internal fields in nominally cubic single crystals of methylammonium lead bromide. We demonstrate that localized flexoelectric fields spatially separate electrons and holes to opposite sides of domain walls, exponentially suppressing recombination. Domain walls thus act as efficient mesoscopic transport channels for long-lived photocarriers, microscopically linking structural heterogeneity to charge transport and offering mechanistically informed design principles for perovskite solar-energy technologies."}],"volume":17,"scopus_import":"1","type":"journal_article","quality_controlled":"1","file":[{"creator":"dernst","success":1,"date_created":"2026-03-02T14:27:56Z","content_type":"application/pdf","checksum":"dd7a98de892d0b5abefca7e290ca0f77","date_updated":"2026-03-02T14:27:56Z","file_name":"2026_NatureComm_Rak.pdf","access_level":"open_access","file_size":2570918,"file_id":"21390","relation":"main_file"}],"department":[{"_id":"ZhAl"},{"_id":"LifeSc"}],"OA_place":"publisher","OA_type":"gold","file_date_updated":"2026-03-02T14:27:56Z","pmid":1,"doi":"10.1038/s41467-026-68660-5","publication_status":"published","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"day":"16","acknowledgement":"We are grateful to A. G. Volosniev for the valuable discussions. We thank D. Milius for the assistance with microscopy. D. R. would like to thank F. Filakovský and T. Čuchráč for the valuable discussions. This research was supported by the Scientific Service Units (SSU) of ISTA through resources provided by the Imaging & Optics Facility (IOF) and the Miba Machine Shop Facility (MS).","ddc":["530"],"title":"Flexoelectric domain walls enable charge separation and transport in cubic perovskites","publication":"Nature Communications","external_id":{"pmid":["41698893"]},"status":"public","publication_identifier":{"eissn":["2041-1723"]},"language":[{"iso":"eng"}],"PlanS_conform":"1","related_material":{"link":[{"description":"News on ISTA website","relation":"press_release","url":"https://ista.ac.at/en/news/explaining-next-generation-solar-cells/"}]},"article_number":"946","intvolume":"        17","DOAJ_listed":"1","date_updated":"2026-04-28T12:12:46Z","date_created":"2026-03-02T10:06:58Z","oa":1,"date_published":"2026-02-16T00:00:00Z","acknowledged_ssus":[{"_id":"Bio"},{"_id":"M-Shop"}],"_id":"21382","citation":{"ista":"Rak D, Lorenc D, Balazs D, Zhumekenov AA, Bakr OM, Alpichshev Z. 2026. Flexoelectric domain walls enable charge separation and transport in cubic perovskites. Nature Communications. 17, 946.","short":"D. Rak, D. Lorenc, D. Balazs, A.A. Zhumekenov, O.M. Bakr, Z. Alpichshev, Nature Communications 17 (2026).","apa":"Rak, D., Lorenc, D., Balazs, D., Zhumekenov, A. A., Bakr, O. M., &#38; Alpichshev, Z. (2026). Flexoelectric domain walls enable charge separation and transport in cubic perovskites. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-026-68660-5\">https://doi.org/10.1038/s41467-026-68660-5</a>","chicago":"Rak, Dmytro, Dusan Lorenc, Daniel Balazs, Ayan A. Zhumekenov, Osman M. Bakr, and Zhanybek Alpichshev. “Flexoelectric Domain Walls Enable Charge Separation and Transport in Cubic Perovskites.” <i>Nature Communications</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41467-026-68660-5\">https://doi.org/10.1038/s41467-026-68660-5</a>.","ama":"Rak D, Lorenc D, Balazs D, Zhumekenov AA, Bakr OM, Alpichshev Z. Flexoelectric domain walls enable charge separation and transport in cubic perovskites. <i>Nature Communications</i>. 2026;17. doi:<a href=\"https://doi.org/10.1038/s41467-026-68660-5\">10.1038/s41467-026-68660-5</a>","ieee":"D. Rak, D. Lorenc, D. Balazs, A. A. Zhumekenov, O. M. Bakr, and Z. Alpichshev, “Flexoelectric domain walls enable charge separation and transport in cubic perovskites,” <i>Nature Communications</i>, vol. 17. Springer Nature, 2026.","mla":"Rak, Dmytro, et al. “Flexoelectric Domain Walls Enable Charge Separation and Transport in Cubic Perovskites.” <i>Nature Communications</i>, vol. 17, 946, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41467-026-68660-5\">10.1038/s41467-026-68660-5</a>."},"article_processing_charge":"Yes","article_type":"original","year":"2026","publisher":"Springer Nature","oa_version":"Published Version","month":"02","author":[{"id":"70313b46-47c2-11ec-9e88-cd79101918fe","first_name":"Dmytro","last_name":"Rak","full_name":"Rak, Dmytro"},{"first_name":"Dusan","id":"40D8A3E6-F248-11E8-B48F-1D18A9856A87","last_name":"Lorenc","full_name":"Lorenc, Dusan"},{"last_name":"Balazs","id":"302BADF6-85FC-11EA-9E3B-B9493DDC885E","first_name":"Daniel","full_name":"Balazs, Daniel","orcid":"0000-0001-7597-043X"},{"full_name":"Zhumekenov, Ayan A.","last_name":"Zhumekenov","first_name":"Ayan A."},{"first_name":"Osman M.","last_name":"Bakr","full_name":"Bakr, Osman M."},{"first_name":"Zhanybek","id":"45E67A2A-F248-11E8-B48F-1D18A9856A87","last_name":"Alpichshev","orcid":"0000-0002-7183-5203","full_name":"Alpichshev, Zhanybek"}]},{"year":"2026","article_type":"original","author":[{"full_name":"Zambra, Valeska","orcid":"0000-0002-8806-5719","id":"467ed36b-dc96-11ea-b7c8-b043a380b282","first_name":"Valeska","last_name":"Zambra"},{"full_name":"Nathwani, Amit","last_name":"Nathwani","id":"1a362536-4d02-11f1-8543-8351136efc50","first_name":"Amit"},{"last_name":"Nauman","id":"32c21954-2022-11eb-9d5f-af9f93c24e71","first_name":"Muhammad","full_name":"Nauman, Muhammad","orcid":"0000-0002-2111-4846"},{"last_name":"Lewin","first_name":"Sylvia K.","full_name":"Lewin, Sylvia K."},{"first_name":"Corey E.","last_name":"Frank","full_name":"Frank, Corey E."},{"first_name":"Nicholas P.","last_name":"Butch","full_name":"Butch, Nicholas P."},{"last_name":"Shekhter","first_name":"Arkady","full_name":"Shekhter, Arkady"},{"first_name":"B. J.","last_name":"Ramshaw","full_name":"Ramshaw, B. J."},{"full_name":"Modic, Kimberly A","orcid":"0000-0001-9760-3147","last_name":"Modic","id":"13C26AC0-EB69-11E9-87C6-5F3BE6697425","first_name":"Kimberly A"}],"publisher":"Springer Nature","oa_version":"Published Version","month":"04","oa":1,"date_updated":"2026-05-11T06:36:00Z","date_created":"2026-05-10T22:02:15Z","DOAJ_listed":"1","article_processing_charge":"Yes","citation":{"apa":"Zambra, V., Nathwani, A., Nauman, M., Lewin, S. K., Frank, C. E., Butch, N. P., … Modic, K. A. (2026). Giant transverse magnetic fluctuations at the edge of re-entrant superconductivity in UTe2. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-026-71899-7\">https://doi.org/10.1038/s41467-026-71899-7</a>","chicago":"Zambra, Valeska, Amit Nathwani, Muhammad Nauman, Sylvia K. Lewin, Corey E. Frank, Nicholas P. Butch, Arkady Shekhter, B. J. Ramshaw, and Kimberly A Modic. “Giant Transverse Magnetic Fluctuations at the Edge of Re-Entrant Superconductivity in UTe2.” <i>Nature Communications</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41467-026-71899-7\">https://doi.org/10.1038/s41467-026-71899-7</a>.","ama":"Zambra V, Nathwani A, Nauman M, et al. Giant transverse magnetic fluctuations at the edge of re-entrant superconductivity in UTe2. <i>Nature Communications</i>. 2026;17. doi:<a href=\"https://doi.org/10.1038/s41467-026-71899-7\">10.1038/s41467-026-71899-7</a>","mla":"Zambra, Valeska, et al. “Giant Transverse Magnetic Fluctuations at the Edge of Re-Entrant Superconductivity in UTe2.” <i>Nature Communications</i>, vol. 17, 3742, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41467-026-71899-7\">10.1038/s41467-026-71899-7</a>.","ieee":"V. Zambra <i>et al.</i>, “Giant transverse magnetic fluctuations at the edge of re-entrant superconductivity in UTe2,” <i>Nature Communications</i>, vol. 17. Springer Nature, 2026.","ista":"Zambra V, Nathwani A, Nauman M, Lewin SK, Frank CE, Butch NP, Shekhter A, Ramshaw BJ, Modic KA. 2026. Giant transverse magnetic fluctuations at the edge of re-entrant superconductivity in UTe2. Nature Communications. 17, 3742.","short":"V. Zambra, A. Nathwani, M. Nauman, S.K. Lewin, C.E. Frank, N.P. Butch, A. Shekhter, B.J. Ramshaw, K.A. Modic, Nature Communications 17 (2026)."},"_id":"21845","acknowledged_ssus":[{"_id":"NanoFab"}],"date_published":"2026-04-29T00:00:00Z","related_material":{"record":[{"status":"public","id":"21174","relation":"research_data"}]},"project":[{"_id":"bd968c70-d553-11ed-ba76-cde40b0aba64","grant_number":"101078696","name":"Gaining leverage with spin liquids and superconductors"}],"intvolume":"        17","arxiv":1,"article_number":"3742","external_id":{"arxiv":["2506.08984"]},"PlanS_conform":"1","language":[{"iso":"eng"}],"publication_identifier":{"eissn":["2041-1723"]},"status":"public","acknowledgement":"We appreciate technical support from Salvatore Bagiante, Evgeniia Volobueva, Lubuna Shafeek, Ali Bangura, and Zoltán Köllö, and scientific discussions with Daniel Agterberg, Johnpierre Paglione, Qimiao Si, Josephine Yu and Yue Yu. V.Z., A.N., M.N., and K.A.M. acknowledge funding received from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (TROPIC-101078696). V.Z., A.N., M.N., and K.A.M. thank the ISTA Nanofabrication Facility for technical support. B.J.R. acknowledges funding from the Office of Basic Energy Sciences of the United States Department of Energy under award number DE-SC0020143 for data analysis and writing. The National High Magnetic Field Laboratory is supported by the National Science Foundation through NSF/DMR-2128556*, the State of Florida, and the U.S. Department of Energy. A.S. acknowledges support from the DOE/BES “Science of 100 T” grant. A.S. thanks Downtown Subscription in Santa Fe, NM, for their patience in hosting him. Sample preparation and characterization were supported by the NSF through DMR-2105191.","day":"29","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_status":"published","title":"Giant transverse magnetic fluctuations at the edge of re-entrant superconductivity in UTe2","ddc":["530"],"publication":"Nature Communications","department":[{"_id":"KiMo"},{"_id":"GradSch"}],"OA_place":"publisher","file":[{"file_size":1784917,"file_id":"21850","relation":"main_file","creator":"dernst","success":1,"date_created":"2026-05-11T06:32:12Z","content_type":"application/pdf","date_updated":"2026-05-11T06:32:12Z","checksum":"8cb95b033ad2a1a7a8181f6f078c05b5","file_name":"2026_NatureComm_Zambra.pdf","access_level":"open_access"}],"doi":"10.1038/s41467-026-71899-7","file_date_updated":"2026-05-11T06:32:12Z","OA_type":"gold","type":"journal_article","quality_controlled":"1","scopus_import":"1","volume":17,"abstract":[{"text":"UTe2 exhibits the remarkable phenomenon of re-entrant superconductivity, whereby the zero-resistance state reappears above 40 tesla after being suppressed with a field of around 10 tesla. One potential pairing mechanism, invoked in the related re-entrant superconductors UCoGe and URhGe, involves transverse fluctuations of a ferromagnetic order parameter. However, the requisite ferromagnetic order—present in both UCoGe and URhGe—is absent in UTe2, and neutron scattering shows instead that the magnetic susceptibility is peaked at an antiferromagnetic wavevector. Here, we measure the magnetotropic susceptibility of UTe2 across two field-angle planes. This quantity is sensitive to the magnetic susceptibility in a direction transverse to the applied magnetic field—a quantity that is not accessed in conventional magnetization measurements. We observe a very large decrease in the magnetotropic susceptibility over a broad range of field orientations, indicating a large increase in the transverse magnetic susceptibility. Because our technique probes the magnetic susceptibility in the long wavelength (q = 0) limit, this suggests that the strong transverse susceptibility arises from ferromagnetic spin fluctuations. These ferromagnetic fluctuations are likely important for understanding the pairing mechanism in UTe2, as all three superconducting phases of UTe2 surround this region of enhanced susceptibility in the field-angle phase diagram.","lang":"eng"}],"has_accepted_license":"1","corr_author":"1"},{"_id":"21872","date_published":"2026-05-12T00:00:00Z","citation":{"ista":"Sunko V, Ahsanullah S, Jain V, Weber S, Kumaran S, Yan J, Orenstein J, Ovchinnikov D. 2026. Magneto-optical Kerr effect in an A-type antiferromagnet. Nature Communications.","short":"V. Sunko, S. Ahsanullah, V. Jain, S. Weber, S. Kumaran, J. Yan, J. Orenstein, D. Ovchinnikov, Nature Communications (2026).","chicago":"Sunko, Veronika, Salman Ahsanullah, Vivek Jain, Sophie Weber, Sivaloganathan Kumaran, Jiaqiang Yan, Joseph Orenstein, and Dmitry Ovchinnikov. “Magneto-Optical Kerr Effect in an A-Type Antiferromagnet.” <i>Nature Communications</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41467-026-72577-4\">https://doi.org/10.1038/s41467-026-72577-4</a>.","apa":"Sunko, V., Ahsanullah, S., Jain, V., Weber, S., Kumaran, S., Yan, J., … Ovchinnikov, D. (2026). Magneto-optical Kerr effect in an A-type antiferromagnet. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-026-72577-4\">https://doi.org/10.1038/s41467-026-72577-4</a>","mla":"Sunko, Veronika, et al. “Magneto-Optical Kerr Effect in an A-Type Antiferromagnet.” <i>Nature Communications</i>, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41467-026-72577-4\">10.1038/s41467-026-72577-4</a>.","ieee":"V. Sunko <i>et al.</i>, “Magneto-optical Kerr effect in an A-type antiferromagnet,” <i>Nature Communications</i>. Springer Nature, 2026.","ama":"Sunko V, Ahsanullah S, Jain V, et al. Magneto-optical Kerr effect in an A-type antiferromagnet. <i>Nature Communications</i>. 2026. doi:<a href=\"https://doi.org/10.1038/s41467-026-72577-4\">10.1038/s41467-026-72577-4</a>"},"article_processing_charge":"Yes","DOAJ_listed":"1","oa":1,"date_created":"2026-05-12T21:31:27Z","date_updated":"2026-05-18T08:04:38Z","publisher":"Springer Nature","month":"05","oa_version":"Published Version","author":[{"full_name":"Sunko, Veronika","orcid":"0000-0003-2724-3523","last_name":"Sunko","id":"23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3","first_name":"Veronika"},{"full_name":"Ahsanullah, Salman","last_name":"Ahsanullah","first_name":"Salman"},{"full_name":"Jain, Vivek","last_name":"Jain","first_name":"Vivek"},{"last_name":"Weber","first_name":"Sophie","full_name":"Weber, Sophie"},{"last_name":"Kumaran","first_name":"Sivaloganathan","full_name":"Kumaran, Sivaloganathan"},{"full_name":"Yan, Jiaqiang","first_name":"Jiaqiang","last_name":"Yan"},{"full_name":"Orenstein, Joseph","first_name":"Joseph","last_name":"Orenstein"},{"first_name":"Dmitry","last_name":"Ovchinnikov","full_name":"Ovchinnikov, Dmitry"}],"article_type":"original","year":"2026","language":[{"iso":"eng"}],"PlanS_conform":"1","status":"public","publication_identifier":{"eissn":["2041-1723"]},"related_material":{"record":[{"relation":"research_data","id":"21422","status":"public"}]},"OA_type":"gold","doi":"10.1038/s41467-026-72577-4","department":[{"_id":"VeSu"}],"OA_place":"publisher","title":"Magneto-optical Kerr effect in an A-type antiferromagnet","publication":"Nature Communications","ddc":["530"],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"epub_ahead","day":"12","acknowledgement":"We thank Christine Kuntscher for providing optical conductivity and reflectance data published in ref. 33, and Nicola Spaldin, Joel Moore and Bevin Huang for useful discussions. V.S. and J.O. received support from the Gordon and Betty Moore Foundation’s EPiQS Initiative through Grant GBMF4537 awarded to J.O. at UC Berkeley. Experimental and theoretical work at LBNL and UC Berkeley was funded by the Quantum Materials (KC2202) program under the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division under Contract No. DE-AC02-05CH11231. Work at the University of Kansas was supported by the U.S. Department of Energy, Office of Science, Basic Energy Sciences, EPSCoR, and Materials Sciences and Engineering Division under Award No. DE-SC0025319. Parts of device fabrication were performed in the KU Nanofabrication Facility, which is supported by the National Institutes of Health NIGMS P30GM145499. Work at ORNL was supported by the U. S. Department of Energy, Office of Science, Basic Energy Sciences, Materials Sciences and Engineering Division. For the DFT calculations we used resources provided by the Swedish National Infrastructure for Computing (SNIC) at C3SE. We acknowledge support from the US National Science Foundation (NSF) Grant Number 2201516 under the Accelnet program of Office of International Science and Engineering (OISE). This publication is funded in part by a QuantEmX grant from ICAM and the Gordon and Betty Moore Foundation through Grant GBMF9616 to S. K.","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41467-026-72577-4"}],"abstract":[{"lang":"eng","text":"Magneto-optic Kerr effect (MOKE) is a powerful probe of broken time-reversal symmetry (T), typically used to study ferromagnets. While MOKE has been observed in some antiferromagnets (AFMs) with vanishing magnetization, it is often associated with structures whose symmetry is lower than basic collinear, bipartite order. In contrast, theory predicts a mechanism for MOKE intrinsic to all AFMs of A-type, i.e. layered AFMs in which ferromagnetic layers are antiferromagnetically aligned. Here we report the experimental confirmation of this mechanism in a bulk AFM. We achieve this by measuring the imaginary component of MOKE as a function of photon energy in MnBi2Te4, an A-type AFM where T is preserved in combination with a translation, and comparing the experimental results with model calculations. Our model suggests that observable MOKE should be expected in all collinear A-type AFMs with out-of-plane spin order, thus enabling optical detection of AFM domains and expanding the scope of MOKE to few-layer AFMs."}],"corr_author":"1","has_accepted_license":"1","type":"journal_article","quality_controlled":"1","scopus_import":"1"},{"date_published":"2026-05-01T00:00:00Z","_id":"21895","article_processing_charge":"Yes","citation":{"ista":"Koolschijn RS, Parthasarathy P, Browning M, Przygodda X, Capitão LP, Clarke WT, Vogels TP, O’Reilly JX, Barron HC. 2026. Noradrenaline causes a spread of association in the hippocampal cognitive map. Nature Communications. 17, 3961.","short":"R.S. Koolschijn, P. Parthasarathy, M. Browning, X. Przygodda, L.P. Capitão, W.T. Clarke, T.P. Vogels, J.X. O’Reilly, H.C. Barron, Nature Communications 17 (2026).","chicago":"Koolschijn, Renée S., Prakriti Parthasarathy, Michael Browning, Xenia Przygodda, Liliana P. Capitão, William T. Clarke, Tim P Vogels, Jill X. O’Reilly, and Helen C. Barron. “Noradrenaline Causes a Spread of Association in the Hippocampal Cognitive Map.” <i>Nature Communications</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41467-026-70659-x\">https://doi.org/10.1038/s41467-026-70659-x</a>.","apa":"Koolschijn, R. S., Parthasarathy, P., Browning, M., Przygodda, X., Capitão, L. P., Clarke, W. T., … Barron, H. C. (2026). Noradrenaline causes a spread of association in the hippocampal cognitive map. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-026-70659-x\">https://doi.org/10.1038/s41467-026-70659-x</a>","mla":"Koolschijn, Renée S., et al. “Noradrenaline Causes a Spread of Association in the Hippocampal Cognitive Map.” <i>Nature Communications</i>, vol. 17, 3961, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41467-026-70659-x\">10.1038/s41467-026-70659-x</a>.","ieee":"R. S. Koolschijn <i>et al.</i>, “Noradrenaline causes a spread of association in the hippocampal cognitive map,” <i>Nature Communications</i>, vol. 17. Springer Nature, 2026.","ama":"Koolschijn RS, Parthasarathy P, Browning M, et al. Noradrenaline causes a spread of association in the hippocampal cognitive map. <i>Nature Communications</i>. 2026;17. doi:<a href=\"https://doi.org/10.1038/s41467-026-70659-x\">10.1038/s41467-026-70659-x</a>"},"DOAJ_listed":"1","date_updated":"2026-05-21T07:05:01Z","date_created":"2026-05-20T14:30:37Z","oa":1,"month":"05","oa_version":"Published Version","publisher":"Springer Nature","author":[{"last_name":"Koolschijn","first_name":"Renée S.","full_name":"Koolschijn, Renée S."},{"first_name":"Prakriti","last_name":"Parthasarathy","full_name":"Parthasarathy, Prakriti"},{"first_name":"Michael","last_name":"Browning","full_name":"Browning, Michael"},{"full_name":"Przygodda, Xenia","first_name":"Xenia","last_name":"Przygodda"},{"last_name":"Capitão","first_name":"Liliana P.","full_name":"Capitão, Liliana P."},{"last_name":"Clarke","first_name":"William T.","full_name":"Clarke, William T."},{"last_name":"Vogels","first_name":"Tim P","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","orcid":"0000-0003-3295-6181","full_name":"Vogels, Tim P"},{"first_name":"Jill X.","last_name":"O’Reilly","full_name":"O’Reilly, Jill X."},{"first_name":"Helen C.","last_name":"Barron","full_name":"Barron, Helen C."}],"article_type":"original","year":"2026","status":"public","publication_identifier":{"eissn":["2041-1723"]},"PlanS_conform":"1","language":[{"iso":"eng"}],"external_id":{"pmid":["41832186"]},"article_number":"3961","intvolume":"        17","file_date_updated":"2026-05-21T07:01:35Z","OA_type":"gold","pmid":1,"doi":"10.1038/s41467-026-70659-x","file":[{"creator":"dernst","success":1,"access_level":"open_access","file_name":"2026_NatureComm_Koolschijn.pdf","date_updated":"2026-05-21T07:01:35Z","checksum":"1b529e06b1c5d6e085d60743317fd4f9","content_type":"application/pdf","date_created":"2026-05-21T07:01:35Z","file_size":2059139,"relation":"main_file","file_id":"21905"}],"OA_place":"publisher","department":[{"_id":"TiVo"}],"title":"Noradrenaline causes a spread of association in the hippocampal cognitive map","ddc":["570"],"publication":"Nature Communications","publication_status":"published","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"We would like to thank Chamith Halahakoon, Phil Cowen, Angharad De Cates, Beata Godlewska, Riccardo De Giorgi, Katherine Smith and Edoardo Ostinelli for enabling this study by providing medical cover. We would like to thank Douglas F. Tomé and Everton J. Agnes for their guidance and advice with earlier versions of the neural network model. We would like to thank Rob Froemke for helpful discussion when preparing the experiments. We thank Leonie Glitz and Valentina Mancini for comments on an earlier version of the manuscript. R.S.K. was supported by an EPSRC/MRC-funded studentship (EP/L016052/1). P.P. was supported by the Cambridge Trust, Trinity Henry Barlow Scholarship and Trinity Hall Brockhouse Scholarship. L.C. is supported by the Foundation for Science and Technology (FCT) (Portuguese State Budget: UID/PSI/01662/2020; Research fellowship: 2021.00415.CEECIND). W.T.C. is funded by the Wellcome Trust [225924/Z/22/Z]. H.C.B. is supported by a UKRI Future Leaders Fellowship (MR/W008939/1) and the Wellcome Institutional Strategic Support Fund. H.C.B. and J.X.O. are supported by the Medical Research Council (MR/W01971X/1). The study was supported by the NIHR Oxford Health Biomedical Research Centre (NIHR203316). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. The Wellcome Centre for Integrative Neuroimaging is supported by core funding from the Wellcome Trust (203139/Z/16/Z and 203139/A/16/Z). This research was funded in part by the Wellcome Trust. For the purpose of open access, the author(s) have applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission.","day":"01","has_accepted_license":"1","abstract":[{"lang":"eng","text":"The mammalian brain organises knowledge about entities in the world and relationships between them using cognitive maps. When forming a cognitive map, there is a necessary trade-off between extending the map to make novel inferences, and storing a veridical copy of past experience. However, the neural mechanisms that control this trade-off remain unknown. Using a cross-scale approach that combines a pharmacological intervention in humans with neural network modelling, we show that the neuromodulator noradrenaline elicits a significant ‘spread of association’ across hippocampal cognitive maps. This neural spread of association can be explained by changes in synaptic plasticity that predict overgeneralisation in behaviour. Thus, elevated noradrenaline during learning increases the ‘smoothing kernel’ for plasticity across the cognitive map, allowing disparate memories to become linked and distorted."}],"volume":17,"scopus_import":"1","type":"journal_article","quality_controlled":"1"},{"publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"acknowledgement":"We thank Dr. Kenneth Johnson for assistance with kinetic analysis and helpful discussion as well as Dr. Jack Bravo and members of the Taylor lab for insightful comments on the manuscript. Data were collected at the Sauer Structural Biology Laboratory at the University of Texas at Austin. This work was supported by a National Institutes of Health grant R35GM138348 (to D.W.T.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Computational resources for this work were supported by the Welch Foundation grant F-1938 (to D.W.T.).","day":"01","ddc":["570"],"title":"Visualization of a multi-turnover Cas9 after product release","publication":"Nature Communications","file":[{"file_size":6875712,"relation":"main_file","file_id":"20018","creator":"dernst","success":1,"access_level":"open_access","date_updated":"2025-07-14T08:28:25Z","date_created":"2025-07-14T08:28:25Z","content_type":"application/pdf","file_name":"2025_NatureComm_Kiernan.pdf","checksum":"fa9a1eaa7e2e60467768cbaed307aceb"}],"department":[{"_id":"LeSa"}],"OA_place":"publisher","pmid":1,"OA_type":"gold","file_date_updated":"2025-07-14T08:28:25Z","doi":"10.1038/s41467-025-60668-7","volume":16,"scopus_import":"1","type":"journal_article","quality_controlled":"1","has_accepted_license":"1","abstract":[{"lang":"eng","text":"While the most widely used CRISPR-Cas enzyme is the Cas9 endonuclease from Streptococcus pyogenes (Cas9), it exhibits single-turnover enzyme kinetics which leads to long residence times on product DNA. This blocks access to DNA repair machinery and acts as a major bottleneck during CRISPR-Cas9 gene editing. Cas9 can eventually be removed from the product by extrinsic factors, such as translocating polymerases, but the mechanisms contributing to Cas9 dissociation following cleavage remain poorly understood. Here, we employ truncated guide RNAs as a strategy to weaken PAM-distal nucleic acid interactions and promote faster enzyme turnover. Using kinetics-guided cryo-EM, we examine the conformational landscape of a multi-turnover Cas9, including the first detailed snapshots of Cas9 dissociating from product DNA. We discovered that while the PAM-distal product dissociates from Cas9 following cleavage, tight binding of the PAM-proximal product directly inhibits re-binding of new targets. Our work provides direct evidence as to why Cas9 acts as a single-turnover enzyme and will guide future Cas9 engineering efforts."}],"article_type":"original","year":"2025","publisher":"Springer Nature","oa_version":"Published Version","month":"07","author":[{"last_name":"Kiernan","id":"91e8ab53-b70a-11ef-adcb-f779f833b451","first_name":"Kaitlyn","full_name":"Kiernan, Kaitlyn"},{"first_name":"David W.","last_name":"Taylor","full_name":"Taylor, David W."}],"DOAJ_listed":"1","date_updated":"2025-07-14T08:30:06Z","date_created":"2025-07-13T22:01:21Z","oa":1,"date_published":"2025-07-01T00:00:00Z","_id":"20002","citation":{"apa":"Kiernan, K., &#38; Taylor, D. W. (2025). Visualization of a multi-turnover Cas9 after product release. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-60668-7\">https://doi.org/10.1038/s41467-025-60668-7</a>","chicago":"Kiernan, Kaitlyn, and David W. Taylor. “Visualization of a Multi-Turnover Cas9 after Product Release.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-025-60668-7\">https://doi.org/10.1038/s41467-025-60668-7</a>.","ama":"Kiernan K, Taylor DW. Visualization of a multi-turnover Cas9 after product release. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-025-60668-7\">10.1038/s41467-025-60668-7</a>","mla":"Kiernan, Kaitlyn, and David W. Taylor. “Visualization of a Multi-Turnover Cas9 after Product Release.” <i>Nature Communications</i>, vol. 16, 5681, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-60668-7\">10.1038/s41467-025-60668-7</a>.","ieee":"K. Kiernan and D. W. Taylor, “Visualization of a multi-turnover Cas9 after product release,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025.","ista":"Kiernan K, Taylor DW. 2025. Visualization of a multi-turnover Cas9 after product release. Nature Communications. 16, 5681.","short":"K. Kiernan, D.W. Taylor, Nature Communications 16 (2025)."},"article_processing_charge":"Yes","article_number":"5681","intvolume":"        16","external_id":{"pmid":["40593576"]},"publication_identifier":{"eissn":["2041-1723"]},"status":"public","language":[{"iso":"eng"}],"PlanS_conform":"1"},{"file":[{"access_level":"open_access","date_created":"2025-09-01T09:46:44Z","checksum":"f28e73963ea1f55876d0d1afca0f706a","content_type":"application/pdf","date_updated":"2025-09-01T09:46:44Z","file_name":"2025_NatureComm_Segos.pdf","success":1,"creator":"dernst","relation":"main_file","file_id":"20261","file_size":3775190}],"department":[{"_id":"CaHe"}],"OA_place":"publisher","pmid":1,"OA_type":"gold","file_date_updated":"2025-09-01T09:46:44Z","doi":"10.1038/s41467-025-62484-5","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","acknowledgement":"We thank members of the Conradt lab, the Center for Cell and Molecular Dynamics (https://www.uclccmd.co.uk/) and T. Schedl for discussions and comments on the manuscript. We thank L. McGuinness for excellent technical support. Some strains were provided by the Caenorhabditis Genetics Center (CGC), which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440). We thank Alex Hajnal (University of Zurich, Switzerland) and Andrew deMello (ETH Zurich, Switzerland) for their support of S.B. This work was supported by a predoctoral fellowship from the Studienstiftung des deutschen Volkes to NM, funds from UCL (Division of Biosciences, UCL LSM Capital Equipment Fund) to B.C., and a Wolfson Fellowship from the Royal Society (https://royalsociety.org/) to B.C. (RSWF\\R1\\180008), and the Biotechnology and Biological Sciences Research Council (https://bbsrc.ukri.org/) (BB/V007572/1 and BB/V015648/1to B.C.).","day":"04","ddc":["570"],"title":"Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo","publication":"Nature Communications","abstract":[{"lang":"eng","text":"The unequal segregation of organelles has been proposed to be an intrinsic mechanism that contributes to cell fate divergence during asymmetric cell division; however, in vivo evidence is sparse. Using super-resolution microscopy, we analysed the segregation of organelles during the division of the neuroblast QL.p in C. elegans larvae. QL.p divides to generate a daughter that survives, QL.pa, and a daughter that dies, QL.pp. We found that mitochondria segregate unequally by density and morphology and that this is dependent on mitochondrial dynamics. Furthermore, we found that mitochondrial density in QL.pp correlates with the time it takes QL.pp to die. We propose that low mitochondrial density in QL.pp promotes the cell death fate and ensures that QL.pp dies in a highly reproducible and timely manner. Our results provide in vivo evidence that the unequal segregation of mitochondria can contribute to cell fate divergence during asymmetric cell division in a developing animal."}],"has_accepted_license":"1","volume":16,"type":"journal_article","quality_controlled":"1","scopus_import":"1","DOAJ_listed":"1","oa":1,"date_updated":"2025-09-01T09:47:29Z","date_created":"2025-08-17T22:01:35Z","_id":"20183","date_published":"2025-08-04T00:00:00Z","article_processing_charge":"Yes","citation":{"ista":"Segos I, Van Eeckhoven J, Berger S, Mishra N, Lambie EJ, Conradt B. 2025. Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo. Nature Communications. 16, 7174.","short":"I. Segos, J. Van Eeckhoven, S. Berger, N. Mishra, E.J. Lambie, B. Conradt, Nature Communications 16 (2025).","chicago":"Segos, Ioannis, Jens Van Eeckhoven, Simon Berger, Nikhil Mishra, Eric J. Lambie, and Barbara Conradt. “Unequal Segregation of Mitochondria during Asymmetric Cell Division Contributes to Cell Fate Divergence in Sister Cells in Vivo.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-025-62484-5\">https://doi.org/10.1038/s41467-025-62484-5</a>.","apa":"Segos, I., Van Eeckhoven, J., Berger, S., Mishra, N., Lambie, E. J., &#38; Conradt, B. (2025). Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-62484-5\">https://doi.org/10.1038/s41467-025-62484-5</a>","mla":"Segos, Ioannis, et al. “Unequal Segregation of Mitochondria during Asymmetric Cell Division Contributes to Cell Fate Divergence in Sister Cells in Vivo.” <i>Nature Communications</i>, vol. 16, 7174, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-62484-5\">10.1038/s41467-025-62484-5</a>.","ieee":"I. Segos, J. Van Eeckhoven, S. Berger, N. Mishra, E. J. Lambie, and B. Conradt, “Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025.","ama":"Segos I, Van Eeckhoven J, Berger S, Mishra N, Lambie EJ, Conradt B. Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-025-62484-5\">10.1038/s41467-025-62484-5</a>"},"article_type":"original","year":"2025","publisher":"Springer Nature","oa_version":"Published Version","month":"08","author":[{"full_name":"Segos, Ioannis","first_name":"Ioannis","last_name":"Segos"},{"full_name":"Van Eeckhoven, Jens","last_name":"Van Eeckhoven","first_name":"Jens"},{"first_name":"Simon","last_name":"Berger","full_name":"Berger, Simon"},{"last_name":"Mishra","id":"C4D70E82-1081-11EA-B3ED-9A4C3DDC885E","first_name":"Nikhil","full_name":"Mishra, Nikhil","orcid":"0000-0002-6425-5788"},{"last_name":"Lambie","first_name":"Eric J.","full_name":"Lambie, Eric J."},{"first_name":"Barbara","last_name":"Conradt","full_name":"Conradt, Barbara"}],"external_id":{"pmid":["40759648"]},"PlanS_conform":"1","language":[{"iso":"eng"}],"status":"public","publication_identifier":{"eissn":["2041-1723"]},"article_number":"7174","intvolume":"        16"},{"article_type":"original","year":"2025","isi":1,"oa_version":"Published Version","publisher":"Springer Nature","month":"10","author":[{"first_name":"Daniel S.","last_name":"King","full_name":"King, Daniel S."},{"first_name":"Dongjin","last_name":"Kim","full_name":"Kim, Dongjin"},{"full_name":"Zhong, Peichen","first_name":"Peichen","last_name":"Zhong"},{"last_name":"Cheng","id":"cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9","first_name":"Bingqing","full_name":"Cheng, Bingqing","orcid":"0000-0002-3584-9632"}],"DOAJ_listed":"1","date_updated":"2026-02-16T12:21:50Z","date_created":"2025-10-12T22:01:25Z","oa":1,"date_published":"2025-10-01T00:00:00Z","_id":"20452","article_processing_charge":"Yes","citation":{"ista":"King DS, Kim D, Zhong P, Cheng B. 2025. Machine learning of charges and long-range interactions from energies and forces. Nature Communications. 16, 8763.","short":"D.S. King, D. Kim, P. Zhong, B. Cheng, Nature Communications 16 (2025).","chicago":"King, Daniel S., Dongjin Kim, Peichen Zhong, and Bingqing Cheng. “Machine Learning of Charges and Long-Range Interactions from Energies and Forces.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-025-63852-x\">https://doi.org/10.1038/s41467-025-63852-x</a>.","apa":"King, D. S., Kim, D., Zhong, P., &#38; Cheng, B. (2025). Machine learning of charges and long-range interactions from energies and forces. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-63852-x\">https://doi.org/10.1038/s41467-025-63852-x</a>","ieee":"D. S. King, D. Kim, P. Zhong, and B. Cheng, “Machine learning of charges and long-range interactions from energies and forces,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025.","mla":"King, Daniel S., et al. “Machine Learning of Charges and Long-Range Interactions from Energies and Forces.” <i>Nature Communications</i>, vol. 16, 8763, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-63852-x\">10.1038/s41467-025-63852-x</a>.","ama":"King DS, Kim D, Zhong P, Cheng B. Machine learning of charges and long-range interactions from energies and forces. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-025-63852-x\">10.1038/s41467-025-63852-x</a>"},"article_number":"8763","intvolume":"        16","external_id":{"isi":["001586620700015"],"pmid":["41034200"]},"publication_identifier":{"eissn":["2041-1723"]},"status":"public","language":[{"iso":"eng"}],"PlanS_conform":"1","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"acknowledgement":"We thank Chunyi Zhang for providing the TiO2(101)/NaCl+NaOH+HCl(aq) dataset and for useful discussions. We thank Jia-Xin Zhu for providing the Pt(111)/KF(aq) dataset. We thank Tsz Wai Ko and Jonas Finkler for useful discussions and for the DFT-optimized Au2-MgO(001) structures. We thank Junmin Chen for discussions. D.K and B.C. acknowledge funding from Toyota Research Institute Synthesis Advanced Research Challenge. D.S.K. and P.Z. acknowledge funding from BIDMaP Postdoctoral Fellowship.","day":"01","title":"Machine learning of charges and long-range interactions from energies and forces","publication":"Nature Communications","ddc":["000"],"file":[{"relation":"main_file","file_id":"20460","file_size":4907055,"access_level":"open_access","date_updated":"2025-10-13T07:54:51Z","date_created":"2025-10-13T07:54:51Z","content_type":"application/pdf","checksum":"34b6005d349bbff85839c4e51d6c8725","file_name":"2025_NatureComm_King.pdf","success":1,"creator":"dernst"}],"department":[{"_id":"BiCh"}],"OA_place":"publisher","file_date_updated":"2025-10-13T07:54:51Z","OA_type":"gold","pmid":1,"doi":"10.1038/s41467-025-63852-x","volume":16,"scopus_import":"1","quality_controlled":"1","type":"journal_article","has_accepted_license":"1","corr_author":"1","abstract":[{"text":"Accurate modeling of long-range forces is critical in atomistic simulations, as they play a central role in determining the properties of material and chemical systems. However, standard machine learning interatomic potentials (MLIPs) often rely on short-range approximations, limiting their applicability to systems with significant electrostatics and dispersion forces. We recently introduced the Latent Ewald Summation (LES) method, which captures long-range electrostatics without explicitly learning atomic charges or charge equilibration. We benchmark LES on diverse and challenging systems, including charged molecules, ionic liquids, electrolyte solutions, polar dipeptides, surface adsorption, electrolyte/solid interfaces, and solid-solid interfaces. Here we show that LES can reproduce the exact atomic charges for classical systems with fixed charges and can infer dipole and quadrupole moments, as well as the dipole derivative with respect to atomic positions, for quantum mechanical systems. Moreover, LES can achieve better accuracy in energy and force predictions compared to methods that explicitly learn from charges.","lang":"eng"}]},{"date_created":"2025-12-07T23:02:00Z","date_updated":"2025-12-09T12:38:44Z","oa":1,"DOAJ_listed":"1","citation":{"ama":"Kneib M, Maussion F, Brun F, et al. Topographically-controlled contribution of avalanches to glacier mass balance in the 21st century. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-025-65608-z\">10.1038/s41467-025-65608-z</a>","mla":"Kneib, Marin, et al. “Topographically-Controlled Contribution of Avalanches to Glacier Mass Balance in the 21st Century.” <i>Nature Communications</i>, vol. 16, 10122, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-65608-z\">10.1038/s41467-025-65608-z</a>.","ieee":"M. Kneib <i>et al.</i>, “Topographically-controlled contribution of avalanches to glacier mass balance in the 21st century,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025.","apa":"Kneib, M., Maussion, F., Brun, F., Carcanade, G., Farinotti, D., Huss, M., … Champollion, N. (2025). Topographically-controlled contribution of avalanches to glacier mass balance in the 21st century. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-65608-z\">https://doi.org/10.1038/s41467-025-65608-z</a>","chicago":"Kneib, Marin, Fabien Maussion, Fanny Brun, Guillem Carcanade, Daniel Farinotti, Matthias Huss, Marit Van Tiel, et al. “Topographically-Controlled Contribution of Avalanches to Glacier Mass Balance in the 21st Century.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-025-65608-z\">https://doi.org/10.1038/s41467-025-65608-z</a>.","short":"M. Kneib, F. Maussion, F. Brun, G. Carcanade, D. Farinotti, M. Huss, M. Van Tiel, A. Jouberton, P. Schmitt, L. Schuster, A. Dehecq, N. Champollion, Nature Communications 16 (2025).","ista":"Kneib M, Maussion F, Brun F, Carcanade G, Farinotti D, Huss M, Van Tiel M, Jouberton A, Schmitt P, Schuster L, Dehecq A, Champollion N. 2025. Topographically-controlled contribution of avalanches to glacier mass balance in the 21st century. Nature Communications. 16, 10122."},"article_processing_charge":"Yes","date_published":"2025-12-01T00:00:00Z","_id":"20728","year":"2025","article_type":"original","author":[{"full_name":"Kneib, Marin","first_name":"Marin","last_name":"Kneib"},{"full_name":"Maussion, Fabien","last_name":"Maussion","first_name":"Fabien"},{"full_name":"Brun, Fanny","first_name":"Fanny","last_name":"Brun"},{"full_name":"Carcanade, Guillem","first_name":"Guillem","last_name":"Carcanade"},{"first_name":"Daniel","last_name":"Farinotti","full_name":"Farinotti, Daniel"},{"full_name":"Huss, Matthias","first_name":"Matthias","last_name":"Huss"},{"full_name":"Van Tiel, Marit","last_name":"Van Tiel","first_name":"Marit"},{"last_name":"Jouberton","id":"f2426a39-920b-11f0-ac40-cbeda2086b9c","first_name":"Achille","full_name":"Jouberton, Achille"},{"full_name":"Schmitt, Patrick","first_name":"Patrick","last_name":"Schmitt"},{"first_name":"Lilian","last_name":"Schuster","full_name":"Schuster, Lilian"},{"full_name":"Dehecq, Amaury","first_name":"Amaury","last_name":"Dehecq"},{"full_name":"Champollion, Nicolas","first_name":"Nicolas","last_name":"Champollion"}],"oa_version":"Published Version","publisher":"Springer Nature","month":"12","external_id":{"pmid":["41298449"]},"status":"public","publication_identifier":{"eissn":["2041-1723"]},"PlanS_conform":"1","language":[{"iso":"eng"}],"intvolume":"        16","article_number":"10122","department":[{"_id":"FrPe"}],"OA_place":"publisher","file":[{"success":1,"creator":"dernst","file_name":"2025_NatureComm_Kneib.pdf","checksum":"5d8e420caa8259b67801f7c87e318d2e","content_type":"application/pdf","date_updated":"2025-12-09T12:37:14Z","date_created":"2025-12-09T12:37:14Z","access_level":"open_access","file_size":2749558,"file_id":"20740","relation":"main_file"}],"doi":"10.1038/s41467-025-65608-z","pmid":1,"OA_type":"gold","file_date_updated":"2025-12-09T12:37:14Z","day":"01","acknowledgement":"This project has received funding from the Swiss National Science Foundation (SNSF) under the Postdoc. Mobility programme, grant agreement P500PN_210739, CAIRN (MK), “Contribution of avalanches to glacier mass balance”, and grant agreement P5R5PN_225605, CAIRN-GLOBAL (MK), “Contribution of avalanches to glacier mass balance at the global scale”. The authors would like to acknowledge the OGGM community for the extensive online documentation, data resources (OGGM-shop) and computing infrastructure that were used as part of this study.","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication":"Nature Communications","ddc":["550"],"title":"Topographically-controlled contribution of avalanches to glacier mass balance in the 21st century","has_accepted_license":"1","abstract":[{"lang":"eng","text":"Glaciers are often located in steep mountain settings and avalanches from surrounding slopes can strongly influence snow accumulation patterns on their surface. This effect has however never been quantified for more than a few glaciers and the impact on the future evolution of glaciers is unclear. We coupled an avalanche and a glacier model to estimate the contribution of avalanches to the accumulation of all glaciers in the world and how this affects their evolution throughout the 21st century. Globally, 3% of the snow accumulation on glaciers comes from avalanches and 1% is removed by avalanches. This net contribution varies between regions and glaciers, with a maximum of 15% for New Zealand. Accounting for avalanches modifies the altitudinal pattern of glacier mass balance and the projected evolution of individual glaciers. The main effects include (1) a longer persistence of small glaciers, with for example three times more ice retained by glaciers smaller than 1 km2 in Central Europe under a low-emission scenario, and (2) an increased sensitivity of high-elevation accumulation zones to future warming. We anticipate the relative influence of avalanches to increase in the future and advocate for a better monitoring of this process and representation in glacier models."}],"scopus_import":"1","type":"journal_article","quality_controlled":"1","volume":16},{"title":"BAF-1–VRK-1 mediated release of meiotic chromosomes from the nuclear periphery is important for genome integrity","ddc":["570"],"publication":"Nature Communications","acknowledgement":"We are grateful to Monique Zetka, Nicola Silva, and Yumi Kim, Needhi Bhalla, George Krohne and Rueyling Lin for providing reagents; Scott Kennedy for sharing the multiplexed FISH library; and members of the Max Perutz Labs’ BioOptics facility (Irmgard Fischer, Josef Gotzmann, Thomas Peterbauer, Clara Bodner, and Nick Wedige) for training and support in image acquisition. We also thank the members of the NGS facility at the Vienna Biocenter. This work was funded by the Austrian Science Fund (FWF) SFB projects F 8805-B (VJ), https://doi.org/10.55776/F88, F 8809-B (ITB), and F8810-B (BV). We are also grateful to members of the V. Jantsch laboratory for helpful discussions. Some strains were provided by the Caenorhabditis Genetics Center, which is funded by the National Institutes of Health Office of Research Infrastructure Programs (P40OD010440).","day":"25","publication_status":"published","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1038/s41467-025-65420-9","pmid":1,"file_date_updated":"2025-12-15T09:25:51Z","OA_type":"gold","OA_place":"publisher","department":[{"_id":"BeVi"}],"file":[{"file_size":8096309,"file_id":"20823","relation":"main_file","creator":"dernst","success":1,"checksum":"a952f7ea050242b79008540de49a0e61","file_name":"2025_NatureComm_Paouneskou.pdf","content_type":"application/pdf","date_created":"2025-12-15T09:25:51Z","date_updated":"2025-12-15T09:25:51Z","access_level":"open_access"}],"scopus_import":"1","type":"journal_article","quality_controlled":"1","volume":16,"has_accepted_license":"1","abstract":[{"lang":"eng","text":"Rapid prophase chromosome movements ensure faithful alignment of the parental homologous chromosomes and successful synapsis formation during meiosis. These movements are driven by cytoplasmic forces transmitted to the nuclear periphery, where chromosome ends are attached through transmembrane proteins. During many developmental stages a specific genome architecture with chromatin nuclear periphery contacts mediates specific gene expression. Whether chromatin is removed from the nuclear periphery as a consequence of chromosome motions or by a specific mechanism is not fully understood. Here, we identify a mechanism to remove chromatin from the nuclear periphery through vaccinia related kinase (VRK-1)–dependent phosphorylation of Barrier to Autointegration Factor 1 (BAF-1) in Caenorhabditis elegans early prophase of meiosis. Interfering with chromatin removal delays chromosome pairing, impairs synapsis, produces oocytes with abnormal chromosomes and elevated apoptosis. Long read sequencing reveals deletions and duplications in offspring lacking VRK-1 underscoring the importance of the BAF-1–VRK-1 module in preserving genome stability in gametes during rapid chromosome movements."}],"author":[{"last_name":"Paouneskou","first_name":"Dimitra","full_name":"Paouneskou, Dimitra"},{"full_name":"Baudrimont, Antoine","first_name":"Antoine","last_name":"Baudrimont"},{"full_name":"Kelemen, Réka K","orcid":"0000-0002-8489-9281","last_name":"Kelemen","id":"48D3F8DE-F248-11E8-B48F-1D18A9856A87","first_name":"Réka K"},{"full_name":"Elkrewi, Marwan N","orcid":"0000-0002-5328-7231","id":"0B46FACA-A8E1-11E9-9BD3-79D1E5697425","first_name":"Marwan N","last_name":"Elkrewi"},{"first_name":"Angela","last_name":"Graf","full_name":"Graf, Angela"},{"first_name":"Shehab","last_name":"Moukbel Ali Aldawla","full_name":"Moukbel Ali Aldawla, Shehab"},{"first_name":"Claudia","last_name":"Kölbl","full_name":"Kölbl, Claudia"},{"last_name":"Tiemann-Boege","first_name":"Irene","full_name":"Tiemann-Boege, Irene"},{"full_name":"Vicoso, Beatriz","orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz","last_name":"Vicoso"},{"full_name":"Jantsch, Verena","first_name":"Verena","last_name":"Jantsch"}],"month":"11","oa_version":"Published Version","publisher":"Springer Nature","year":"2025","article_type":"original","article_processing_charge":"Yes","citation":{"short":"D. Paouneskou, A. Baudrimont, R.K. Kelemen, M.N. Elkrewi, A. Graf, S. Moukbel Ali Aldawla, C. Kölbl, I. Tiemann-Boege, B. Vicoso, V. Jantsch, Nature Communications 16 (2025).","ista":"Paouneskou D, Baudrimont A, Kelemen RK, Elkrewi MN, Graf A, Moukbel Ali Aldawla S, Kölbl C, Tiemann-Boege I, Vicoso B, Jantsch V. 2025. BAF-1–VRK-1 mediated release of meiotic chromosomes from the nuclear periphery is important for genome integrity. Nature Communications. 16, 10446.","ieee":"D. Paouneskou <i>et al.</i>, “BAF-1–VRK-1 mediated release of meiotic chromosomes from the nuclear periphery is important for genome integrity,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025.","mla":"Paouneskou, Dimitra, et al. “BAF-1–VRK-1 Mediated Release of Meiotic Chromosomes from the Nuclear Periphery Is Important for Genome Integrity.” <i>Nature Communications</i>, vol. 16, 10446, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-65420-9\">10.1038/s41467-025-65420-9</a>.","ama":"Paouneskou D, Baudrimont A, Kelemen RK, et al. BAF-1–VRK-1 mediated release of meiotic chromosomes from the nuclear periphery is important for genome integrity. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-025-65420-9\">10.1038/s41467-025-65420-9</a>","chicago":"Paouneskou, Dimitra, Antoine Baudrimont, Réka K Kelemen, Marwan N Elkrewi, Angela Graf, Shehab Moukbel Ali Aldawla, Claudia Kölbl, Irene Tiemann-Boege, Beatriz Vicoso, and Verena Jantsch. “BAF-1–VRK-1 Mediated Release of Meiotic Chromosomes from the Nuclear Periphery Is Important for Genome Integrity.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-025-65420-9\">https://doi.org/10.1038/s41467-025-65420-9</a>.","apa":"Paouneskou, D., Baudrimont, A., Kelemen, R. K., Elkrewi, M. N., Graf, A., Moukbel Ali Aldawla, S., … Jantsch, V. (2025). BAF-1–VRK-1 mediated release of meiotic chromosomes from the nuclear periphery is important for genome integrity. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-65420-9\">https://doi.org/10.1038/s41467-025-65420-9</a>"},"date_published":"2025-11-25T00:00:00Z","_id":"20796","date_updated":"2025-12-15T09:28:37Z","date_created":"2025-12-11T10:45:06Z","oa":1,"DOAJ_listed":"1","intvolume":"        16","article_number":"10446","project":[{"name":"The highjacking of meiosis for asexual reproduction","_id":"34ae1506-11ca-11ed-8bc3-c14f4c474396","grant_number":"F8810"}],"publication_identifier":{"eissn":["2041-1723"]},"status":"public","PlanS_conform":"1","language":[{"iso":"eng"}],"external_id":{"pmid":["41290579"]}},{"DOAJ_listed":"1","oa":1,"date_updated":"2025-02-27T12:41:25Z","date_created":"2025-01-12T23:04:00Z","_id":"18820","date_published":"2025-01-02T00:00:00Z","citation":{"short":"R. Wild, F. Wodaczek, V. Del Tatto, B. Cheng, A. Laio, Nature Communications 16 (2025).","ista":"Wild R, Wodaczek F, Del Tatto V, Cheng B, Laio A. 2025. Automatic feature selection and weighting in molecular systems using Differentiable Information Imbalance. Nature Communications. 16, 270.","mla":"Wild, Romina, et al. “Automatic Feature Selection and Weighting in Molecular Systems Using Differentiable Information Imbalance.” <i>Nature Communications</i>, vol. 16, 270, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-024-55449-7\">10.1038/s41467-024-55449-7</a>.","ieee":"R. Wild, F. Wodaczek, V. Del Tatto, B. Cheng, and A. Laio, “Automatic feature selection and weighting in molecular systems using Differentiable Information Imbalance,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025.","ama":"Wild R, Wodaczek F, Del Tatto V, Cheng B, Laio A. Automatic feature selection and weighting in molecular systems using Differentiable Information Imbalance. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-024-55449-7\">10.1038/s41467-024-55449-7</a>","chicago":"Wild, Romina, Felix Wodaczek, Vittorio Del Tatto, Bingqing Cheng, and Alessandro Laio. “Automatic Feature Selection and Weighting in Molecular Systems Using Differentiable Information Imbalance.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-024-55449-7\">https://doi.org/10.1038/s41467-024-55449-7</a>.","apa":"Wild, R., Wodaczek, F., Del Tatto, V., Cheng, B., &#38; Laio, A. (2025). Automatic feature selection and weighting in molecular systems using Differentiable Information Imbalance. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-024-55449-7\">https://doi.org/10.1038/s41467-024-55449-7</a>"},"article_processing_charge":"Yes","article_type":"original","isi":1,"year":"2025","month":"01","oa_version":"Published Version","publisher":"Springer Nature","author":[{"last_name":"Wild","first_name":"Romina","full_name":"Wild, Romina"},{"last_name":"Wodaczek","id":"8b4b6a9f-32b0-11ee-9fa8-bbe85e26258e","first_name":"Felix","full_name":"Wodaczek, Felix","orcid":"0009-0000-1457-795X"},{"full_name":"Del Tatto, Vittorio","first_name":"Vittorio","last_name":"Del Tatto"},{"full_name":"Cheng, Bingqing","orcid":"0000-0002-3584-9632","id":"cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9","first_name":"Bingqing","last_name":"Cheng"},{"first_name":"Alessandro","last_name":"Laio","full_name":"Laio, Alessandro"}],"external_id":{"isi":["001389959100009"],"pmid":["39747013"]},"language":[{"iso":"eng"}],"publication_identifier":{"eissn":["2041-1723"]},"status":"public","article_number":"270","intvolume":"        16","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","file":[{"file_id":"18846","relation":"main_file","file_size":1216738,"date_created":"2025-01-14T06:59:25Z","checksum":"b3d0f3568d9a87c494cf231a5324029a","content_type":"application/pdf","date_updated":"2025-01-14T06:59:25Z","file_name":"2025_NatureComm_Wild.pdf","access_level":"open_access","success":1,"creator":"dernst"}],"department":[{"_id":"AnSa"},{"_id":"BiCh"}],"OA_place":"publisher","pmid":1,"file_date_updated":"2025-01-14T06:59:25Z","OA_type":"gold","doi":"10.1038/s41467-024-55449-7","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"publication_status":"published","acknowledgement":"The authors thank Dr. Matteo Carli for providing the CLN025 replica exchange MD trajectory and Matteo Allione for the fruitful discussions connected with the idea of the linear scaling estimator. This work was partially funded by NextGenerationEU through the Italian National Centre for HPC, Big Data, and Quantum Computing (Grant No. CN00000013 received by A.L.). A.L. also acknowledges financial support by the region Friuli Venezia Giulia (project F53C22001770002 received by A.L.).","day":"02","title":"Automatic feature selection and weighting in molecular systems using Differentiable Information Imbalance","publication":"Nature Communications","ddc":["570"],"abstract":[{"text":"Feature selection is essential in the analysis of molecular systems and many other fields, but several uncertainties remain: What is the optimal number of features for a simplified, interpretable model that retains essential information? How should features with different units be aligned, and how should their relative importance be weighted? Here, we introduce the Differentiable Information Imbalance (DII), an automated method to rank information content between sets of features. Using distances in a ground truth feature space, DII identifies a low-dimensional subset of features that best preserves these relationships. Each feature is scaled by a weight, which is optimized by minimizing the DII through gradient descent. This allows simultaneously performing unit alignment and relative importance scaling, while preserving interpretability. DII can also produce sparse solutions and determine the optimal size of the reduced feature space. We demonstrate the usefulness of this approach on two benchmark molecular problems: (1) identifying collective variables that describe conformations of a biomolecule, and (2) selecting features for training a machine-learning force field. These results show the potential of DII in addressing feature selection challenges and optimizing dimensionality in various applications. The method is available in the Python library DADApy.","lang":"eng"}],"has_accepted_license":"1","volume":16,"type":"journal_article","quality_controlled":"1","scopus_import":"1"},{"volume":16,"quality_controlled":"1","type":"journal_article","scopus_import":"1","abstract":[{"text":"Type II CRISPR endonucleases are widely used programmable genome editing tools. Recently, CRISPR-Cas systems with highly compact nucleases have been discovered, including Cas9d (a type II-D nuclease). Here, we report the cryo-EM structures of a Cas9d nuclease (747 amino acids in length) in multiple functional states, revealing a stepwise process of DNA targeting involving a conformational switch in a REC2 domain insertion. Our structures provide insights into the intricately folded guide RNA which acts as a structural scaffold to anchor small, flexible protein domains for DNA recognition. The sgRNA can be truncated by up to ~25% yet still retain activity in vivo. Using ancestral sequence reconstruction, we generated compact nucleases capable of efficient genome editing in mammalian cells. Collectively, our results provide mechanistic insights into the evolution and DNA targeting of diverse type II CRISPR-Cas systems, providing a blueprint for future re-engineering of minimal RNA-guided DNA endonucleases.","lang":"eng"}],"has_accepted_license":"1","ddc":["570"],"title":"DNA targeting by compact Cas9d and its resurrected ancestor","publication":"Nature Communications","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_status":"published","day":"07","acknowledgement":"We would like to thank M. Ocampo Camacho and M.F. Canedo Ocampo for assistance with the figures. We thank M. Hooper for assistance developing the GFP assay and operating the CE machine for in vitro cleavage analysis. We thank E. Schwartz and A. Brilot for expert cryo-EM support in the Sauer Structural Biology Laboratory at UT Austin. This work was funded, in part, by a sponsored research agreement with Metagenomi, Inc. (to D.W.T), a Welch Foundation Research Grant F-1938 (to D.W.T), and the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation Medical Research Grant (to D.W.T), and a grant from the National Institute of Allergy and Infectious Diseases (NIAID 1R01AI110577 to K.A.J.).","OA_type":"gold","file_date_updated":"2025-01-22T14:35:22Z","pmid":1,"doi":"10.1038/s41467-024-55573-4","file":[{"file_size":5450660,"relation":"main_file","file_id":"18869","creator":"dernst","success":1,"access_level":"open_access","date_updated":"2025-01-22T14:35:22Z","content_type":"application/pdf","checksum":"885e96690620790d5c9f188a1587b4cd","date_created":"2025-01-22T14:35:22Z","file_name":"2025_NatureComm_Ocampo.pdf"}],"OA_place":"publisher","department":[{"_id":"JaBr"}],"article_number":"457","intvolume":"        16","language":[{"iso":"eng"}],"status":"public","publication_identifier":{"eissn":["2041-1723"]},"external_id":{"pmid":["39774105"]},"oa_version":"Published Version","publisher":"Springer Nature","month":"01","author":[{"full_name":"Ocampo, Rodrigo Fregoso","last_name":"Ocampo","first_name":"Rodrigo Fregoso"},{"first_name":"Jack Peter Kelly","id":"96aecfa5-8931-11ee-af30-aa6a5d6eee0e","last_name":"Bravo","orcid":"0000-0003-0456-0753","full_name":"Bravo, Jack Peter Kelly"},{"first_name":"Tyler L.","last_name":"Dangerfield","full_name":"Dangerfield, Tyler L."},{"first_name":"Isabel","last_name":"Nocedal","full_name":"Nocedal, Isabel"},{"first_name":"Samatar A.","last_name":"Jirde","full_name":"Jirde, Samatar A."},{"last_name":"Alexander","first_name":"Lisa M.","full_name":"Alexander, Lisa M."},{"first_name":"Nicole C.","last_name":"Thomas","full_name":"Thomas, Nicole C."},{"last_name":"Das","first_name":"Anjali","full_name":"Das, Anjali"},{"last_name":"Nielson","first_name":"Sarah","full_name":"Nielson, Sarah"},{"full_name":"Johnson, Kenneth A.","last_name":"Johnson","first_name":"Kenneth A."},{"full_name":"Brown, Christopher T.","first_name":"Christopher T.","last_name":"Brown"},{"first_name":"Cristina N.","last_name":"Butterfield","full_name":"Butterfield, Cristina N."},{"full_name":"Goltsman, Daniela S.A.","last_name":"Goltsman","first_name":"Daniela S.A."},{"last_name":"Taylor","first_name":"David W.","full_name":"Taylor, David W."}],"article_type":"original","year":"2025","_id":"18848","date_published":"2025-01-07T00:00:00Z","article_processing_charge":"Yes","citation":{"short":"R.F. Ocampo, J.P.K. Bravo, T.L. Dangerfield, I. Nocedal, S.A. Jirde, L.M. Alexander, N.C. Thomas, A. Das, S. Nielson, K.A. Johnson, C.T. Brown, C.N. Butterfield, D.S.A. Goltsman, D.W. Taylor, Nature Communications 16 (2025).","ista":"Ocampo RF, Bravo JPK, Dangerfield TL, Nocedal I, Jirde SA, Alexander LM, Thomas NC, Das A, Nielson S, Johnson KA, Brown CT, Butterfield CN, Goltsman DSA, Taylor DW. 2025. DNA targeting by compact Cas9d and its resurrected ancestor. Nature Communications. 16, 457.","ieee":"R. F. Ocampo <i>et al.</i>, “DNA targeting by compact Cas9d and its resurrected ancestor,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025.","mla":"Ocampo, Rodrigo Fregoso, et al. “DNA Targeting by Compact Cas9d and Its Resurrected Ancestor.” <i>Nature Communications</i>, vol. 16, 457, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-024-55573-4\">10.1038/s41467-024-55573-4</a>.","ama":"Ocampo RF, Bravo JPK, Dangerfield TL, et al. DNA targeting by compact Cas9d and its resurrected ancestor. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-024-55573-4\">10.1038/s41467-024-55573-4</a>","chicago":"Ocampo, Rodrigo Fregoso, Jack Peter Kelly Bravo, Tyler L. Dangerfield, Isabel Nocedal, Samatar A. Jirde, Lisa M. Alexander, Nicole C. Thomas, et al. “DNA Targeting by Compact Cas9d and Its Resurrected Ancestor.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-024-55573-4\">https://doi.org/10.1038/s41467-024-55573-4</a>.","apa":"Ocampo, R. F., Bravo, J. P. K., Dangerfield, T. L., Nocedal, I., Jirde, S. A., Alexander, L. M., … Taylor, D. W. (2025). DNA targeting by compact Cas9d and its resurrected ancestor. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-024-55573-4\">https://doi.org/10.1038/s41467-024-55573-4</a>"},"DOAJ_listed":"1","oa":1,"date_updated":"2025-07-03T11:58:22Z","date_created":"2025-01-19T23:01:50Z"},{"type":"journal_article","quality_controlled":"1","scopus_import":"1","volume":16,"abstract":[{"lang":"eng","text":"Recent advances in the field of bottom-up synthetic biology have led to the development of synthetic cells that mimic some features of real cells, such as division, protein synthesis, or DNA replication. Larger assemblies of synthetic cells may be used to form prototissues. However, existing prototissues are limited by their relatively small lateral dimensions or their lack of remodeling ability. Here, we introduce a lipid-based tissue mimetic that can be easily prepared and functionalized, consisting of a millimeter-sized “lipid-foam” with individual micrometer-sized compartments bound by lipid bilayers. We characterize the structural and mechanical properties of the lipid-foam tissue mimetic, and we demonstrate self-healing capabilities enabled by the fluidity of the lipid bilayers. Upon inclusion of bacteria in the tissue compartments, we observe that the tissue mimetic exhibits network-wide tension fluctuations driven by membrane tension generation by the swimming bacteria. Active tension fluctuations facilitate the fluidization and reorganization of the prototissue, providing a versatile platform for understanding and mimicking biological tissues."}],"has_accepted_license":"1","acknowledgement":"This research was supported in part by the National Science Foundation under Grant No. 1844336 (J.S.), 2239567 (A.P), and MRSEC DMR-2308691 (A.G., N.P.K.) and the National Institutes of Health under Grant No. 1R35GM147170-01 (A.P). J.S. thanks Reinhard Lipowsky for discussions on stability of foams.\r\nOpen Access funding enabled and organized by Projekt DEAL.","day":"27","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_status":"published","title":"Remodeling of lipid-foam prototissues by network-wide tension fluctuations induced by active particles","ddc":["570"],"publication":"Nature Communications","OA_place":"publisher","department":[{"_id":"EdHa"}],"file":[{"file_id":"19411","relation":"main_file","file_size":2260791,"date_created":"2025-03-17T09:43:27Z","checksum":"3bbae9b470c639005815342a39e96918","file_name":"2025_NatureComm_Gu.pdf","date_updated":"2025-03-17T09:43:27Z","content_type":"application/pdf","access_level":"open_access","success":1,"creator":"dernst"}],"doi":"10.1038/s41467-025-57178-x","OA_type":"gold","file_date_updated":"2025-03-17T09:43:27Z","pmid":1,"intvolume":"        16","article_number":"2026","external_id":{"pmid":["40016255"],"isi":["001435269000002"]},"language":[{"iso":"eng"}],"status":"public","publication_identifier":{"eissn":["2041-1723"]},"year":"2025","isi":1,"article_type":"original","author":[{"full_name":"Gu, Andre A.","last_name":"Gu","first_name":"Andre A."},{"orcid":"0000-0003-0506-4217","full_name":"Ucar, Mehmet C","first_name":"Mehmet C","id":"50B2A802-6007-11E9-A42B-EB23E6697425","last_name":"Ucar"},{"last_name":"Tran","first_name":"Peter","full_name":"Tran, Peter"},{"full_name":"Prindle, Arthur","first_name":"Arthur","last_name":"Prindle"},{"full_name":"Kamat, Neha P.","first_name":"Neha P.","last_name":"Kamat"},{"first_name":"Jan","last_name":"Steinkühler","full_name":"Steinkühler, Jan"}],"publisher":"Springer Nature","oa_version":"Published Version","month":"02","oa":1,"date_created":"2025-03-16T23:01:23Z","date_updated":"2025-09-30T10:59:30Z","DOAJ_listed":"1","article_processing_charge":"Yes (via OA deal)","citation":{"ama":"Gu AA, Ucar MC, Tran P, Prindle A, Kamat NP, Steinkühler J. Remodeling of lipid-foam prototissues by network-wide tension fluctuations induced by active particles. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-025-57178-x\">10.1038/s41467-025-57178-x</a>","ieee":"A. A. Gu, M. C. Ucar, P. Tran, A. Prindle, N. P. Kamat, and J. Steinkühler, “Remodeling of lipid-foam prototissues by network-wide tension fluctuations induced by active particles,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025.","mla":"Gu, Andre A., et al. “Remodeling of Lipid-Foam Prototissues by Network-Wide Tension Fluctuations Induced by Active Particles.” <i>Nature Communications</i>, vol. 16, 2026, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-57178-x\">10.1038/s41467-025-57178-x</a>.","apa":"Gu, A. A., Ucar, M. C., Tran, P., Prindle, A., Kamat, N. P., &#38; Steinkühler, J. (2025). Remodeling of lipid-foam prototissues by network-wide tension fluctuations induced by active particles. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-57178-x\">https://doi.org/10.1038/s41467-025-57178-x</a>","chicago":"Gu, Andre A., Mehmet C Ucar, Peter Tran, Arthur Prindle, Neha P. Kamat, and Jan Steinkühler. “Remodeling of Lipid-Foam Prototissues by Network-Wide Tension Fluctuations Induced by Active Particles.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-025-57178-x\">https://doi.org/10.1038/s41467-025-57178-x</a>.","short":"A.A. Gu, M.C. Ucar, P. Tran, A. Prindle, N.P. Kamat, J. Steinkühler, Nature Communications 16 (2025).","ista":"Gu AA, Ucar MC, Tran P, Prindle A, Kamat NP, Steinkühler J. 2025. Remodeling of lipid-foam prototissues by network-wide tension fluctuations induced by active particles. Nature Communications. 16, 2026."},"_id":"19402","date_published":"2025-02-27T00:00:00Z"},{"doi":"10.1038/s41467-025-66562-6","file_date_updated":"2026-01-12T09:30:15Z","OA_type":"gold","pmid":1,"department":[{"_id":"PeJo"}],"OA_place":"publisher","file":[{"file_id":"20978","relation":"main_file","file_size":7629997,"file_name":"2025_NatureComm_Maslarova.pdf","checksum":"a8a1670e197484382e087be60f643945","content_type":"application/pdf","date_created":"2026-01-12T09:30:15Z","date_updated":"2026-01-12T09:30:15Z","access_level":"open_access","creator":"dernst","success":1}],"ddc":["570"],"title":"Spatiotemporal patterns differentiate hippocampal sharp-wave ripples from interictal epileptiform discharges in mice and humans","publication":"Nature Communications","day":"30","acknowledgement":"We thank Karl Rössler and Sebastian Brandner for the human SEEG implantations; Katja Kobow for providing the histopathological findings of the patients; Jay Jeschke for help with human electrode localization; Esha Brahmbhatt and Deren Aykan for help with animal habituation; Mursel Karadas for the rodent treadmill design; Nicholas Paleologos, Noam Nitzan, Michael D Hadler and Samuel McKenzie for rating events in a human ripple survey included in a previous version of the manuscript; Nicholas Paleologos for sharing NYU iEEG data for validating UMAP parameters; Julio Esparza for help on the topological analysis through discussions; Thomas Hainmüller, Yiyao Zhang and Mursel Karadas for feedback on the manuscript. We would like to acknowledge Corticale SRL (Genoa, Italy) for providing the SiNAPS probes, and NeuroNexus (Ann Arbor, MI) for their contribution of the data acquisition system and Radiens software. We further acknowledge both Corticale and NeuroNexus for training and support making this research possible. This work was supported by the German Research Foundation (DFG; Walter Benjamin Fellowship MA 10301/1-1, A.M.), NYU Langone Health Finding a Cure for Epilepsy and Seizures (FACES, A.M.), the NOMIS Fellowship (A.N.-O.), the National Institutes of Health (R01NS127954, K23NS104252, A.L.; MH122391, U19NS107616, R01MH139216 G.B.,), and the NYU Department of Neurology (A.L.).","tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","abstract":[{"lang":"eng","text":"Hippocampal sharp-wave ripples (SPW-Rs) are high-frequency oscillations critical for memory consolidation. Despite extensive characterization in rodents, their detection in humans is limited by coarse spatial sampling, interictal epileptiform discharges (IEDs), and a lack of consensus on human ripple localization and morphology. Here, we demonstrate that mouse and human hippocampal ripples share spatial, spectral and temporal features, which are clearly distinct from IEDs. In recordings from male APP/PS1 mice, SPW-Rs were distinguishable from IEDs by multiple criteria. Hippocampal ripples recorded during NREM sleep in female and male surgical epilepsy patients exhibited similar narrowband frequency peaks and multiple ripple cycles in the CA1 and subiculum regions. Conversely, IEDs showed a broad spatial extent and wide-band frequency power. We developed a semi-automated, ripple curation toolbox (ripmap) to separate event waveforms by low-dimensional embedding to reduce false-positive rate in selected ripple channels. Our approach improves ripple detection and provides a firm foundation for future human memory research."}],"has_accepted_license":"1","type":"journal_article","quality_controlled":"1","scopus_import":"1","volume":16,"article_processing_charge":"Yes","citation":{"chicago":"Maslarova, Anna, Jiyun N. Shin, Andrea C Navas Olivé, Mihály Vöröslakos, Hajo Hamer, Arnd Doerfler, Simon Henin, György Buzsáki, and Anli Liu. “Spatiotemporal Patterns Differentiate Hippocampal Sharp-Wave Ripples from Interictal Epileptiform Discharges in Mice and Humans.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-025-66562-6\">https://doi.org/10.1038/s41467-025-66562-6</a>.","apa":"Maslarova, A., Shin, J. N., Navas Olivé, A. C., Vöröslakos, M., Hamer, H., Doerfler, A., … Liu, A. (2025). Spatiotemporal patterns differentiate hippocampal sharp-wave ripples from interictal epileptiform discharges in mice and humans. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-66562-6\">https://doi.org/10.1038/s41467-025-66562-6</a>","mla":"Maslarova, Anna, et al. “Spatiotemporal Patterns Differentiate Hippocampal Sharp-Wave Ripples from Interictal Epileptiform Discharges in Mice and Humans.” <i>Nature Communications</i>, vol. 16, 11636, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-66562-6\">10.1038/s41467-025-66562-6</a>.","ieee":"A. Maslarova <i>et al.</i>, “Spatiotemporal patterns differentiate hippocampal sharp-wave ripples from interictal epileptiform discharges in mice and humans,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025.","ama":"Maslarova A, Shin JN, Navas Olivé AC, et al. Spatiotemporal patterns differentiate hippocampal sharp-wave ripples from interictal epileptiform discharges in mice and humans. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-025-66562-6\">10.1038/s41467-025-66562-6</a>","ista":"Maslarova A, Shin JN, Navas Olivé AC, Vöröslakos M, Hamer H, Doerfler A, Henin S, Buzsáki G, Liu A. 2025. Spatiotemporal patterns differentiate hippocampal sharp-wave ripples from interictal epileptiform discharges in mice and humans. Nature Communications. 16, 11636.","short":"A. Maslarova, J.N. Shin, A.C. Navas Olivé, M. Vöröslakos, H. Hamer, A. Doerfler, S. Henin, G. Buzsáki, A. Liu, Nature Communications 16 (2025)."},"_id":"20977","date_published":"2025-12-30T00:00:00Z","oa":1,"date_created":"2026-01-11T23:01:35Z","date_updated":"2026-01-12T09:31:56Z","DOAJ_listed":"1","author":[{"last_name":"Maslarova","first_name":"Anna","full_name":"Maslarova, Anna"},{"full_name":"Shin, Jiyun N.","last_name":"Shin","first_name":"Jiyun N."},{"orcid":"0000-0002-9280-8597","full_name":"Navas Olivé, Andrea C","last_name":"Navas Olivé","first_name":"Andrea C","id":"739d26c9-52e8-11ee-8d72-f14d3893b4ce"},{"last_name":"Vöröslakos","first_name":"Mihály","full_name":"Vöröslakos, Mihály"},{"first_name":"Hajo","last_name":"Hamer","full_name":"Hamer, Hajo"},{"full_name":"Doerfler, Arnd","first_name":"Arnd","last_name":"Doerfler"},{"full_name":"Henin, Simon","first_name":"Simon","last_name":"Henin"},{"full_name":"Buzsáki, György","last_name":"Buzsáki","first_name":"György"},{"last_name":"Liu","first_name":"Anli","full_name":"Liu, Anli"}],"month":"12","oa_version":"Published Version","publisher":"Springer Nature","year":"2025","article_type":"original","language":[{"iso":"eng"}],"status":"public","publication_identifier":{"eissn":["2041-1723"]},"external_id":{"pmid":["39975118"]},"intvolume":"        16","article_number":"11636","project":[{"name":"NOMIS Fellowship Program","_id":"9B861AAC-BA93-11EA-9121-9846C619BF3A"}]},{"oa_version":"Published Version","month":"12","publisher":"Springer Nature","author":[{"last_name":"Milivojev","first_name":"Nadja","full_name":"Milivojev, Nadja"},{"full_name":"Scaramuzza, Federico","last_name":"Scaramuzza","first_name":"Federico"},{"first_name":"Pedro Ozório","last_name":"Brum","full_name":"Brum, Pedro Ozório"},{"first_name":"Camila L","id":"625aea67-91c1-11f0-aad8-f71452b4174d","last_name":"Velastegui Gamboa","full_name":"Velastegui Gamboa, Camila L"},{"full_name":"Andreatta, Gabriele","last_name":"Andreatta","first_name":"Gabriele"},{"last_name":"Raible","first_name":"Florian","full_name":"Raible, Florian"},{"full_name":"Tessmar-Raible, Kristin","first_name":"Kristin","last_name":"Tessmar-Raible"}],"article_type":"original","year":"2025","date_published":"2025-12-01T00:00:00Z","_id":"21248","citation":{"ama":"Milivojev N, Scaramuzza F, Brum PO, et al. Light-modulated stem cells in the camera-type eye of an annelid model for adult brain plasticity. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-025-65631-0\">10.1038/s41467-025-65631-0</a>","ieee":"N. Milivojev <i>et al.</i>, “Light-modulated stem cells in the camera-type eye of an annelid model for adult brain plasticity,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025.","mla":"Milivojev, Nadja, et al. “Light-Modulated Stem Cells in the Camera-Type Eye of an Annelid Model for Adult Brain Plasticity.” <i>Nature Communications</i>, vol. 16, 9861, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-65631-0\">10.1038/s41467-025-65631-0</a>.","apa":"Milivojev, N., Scaramuzza, F., Brum, P. O., Velastegui Gamboa, C. L., Andreatta, G., Raible, F., &#38; Tessmar-Raible, K. (2025). Light-modulated stem cells in the camera-type eye of an annelid model for adult brain plasticity. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-65631-0\">https://doi.org/10.1038/s41467-025-65631-0</a>","chicago":"Milivojev, Nadja, Federico Scaramuzza, Pedro Ozório Brum, Camila L Velastegui Gamboa, Gabriele Andreatta, Florian Raible, and Kristin Tessmar-Raible. “Light-Modulated Stem Cells in the Camera-Type Eye of an Annelid Model for Adult Brain Plasticity.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-025-65631-0\">https://doi.org/10.1038/s41467-025-65631-0</a>.","short":"N. Milivojev, F. Scaramuzza, P.O. Brum, C.L. Velastegui Gamboa, G. Andreatta, F. Raible, K. Tessmar-Raible, Nature Communications 16 (2025).","ista":"Milivojev N, Scaramuzza F, Brum PO, Velastegui Gamboa CL, Andreatta G, Raible F, Tessmar-Raible K. 2025. Light-modulated stem cells in the camera-type eye of an annelid model for adult brain plasticity. Nature Communications. 16, 9861."},"article_processing_charge":"Yes (via OA deal)","DOAJ_listed":"1","date_created":"2026-02-16T15:38:11Z","date_updated":"2026-02-18T06:41:35Z","oa":1,"article_number":"9861","intvolume":"        16","status":"public","publication_identifier":{"eissn":["2041-1723"]},"PlanS_conform":"1","language":[{"iso":"eng"}],"title":"Light-modulated stem cells in the camera-type eye of an annelid model for adult brain plasticity","publication":"Nature Communications","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"We are grateful to Andrij Belokurov, Margaryta Borysova and Netsanet Getachew for routine worm cultures and genotyping support, Lena Stumbauer for practical help, as well as all members of the Tessmar-Raible and Raible labs for constructive discussions. This work was supported by, Helmholtz Society, distinguished professorship by the Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research (K.T.-R.), H2020 European Research Council, ERC Grant Agreement #819952 (K.T.-R.), Austrian Science Funds (FWF), SFB F78 (F.R., K.T-R; https://doi.org/10.55776/F78), the Human Frontier Science Program (HFSP), #RGP021/2024, https://doi.org/10.52044/HFSP.RGP0212024.pc.gr.194174 (KT-R), University of Vienna Research Platform SinCeReSt (F.R.), For open access purposes, K.T.-R. has applied a CC BY public copyright license to any author accepted manuscript version arising from this submission. We acknowledge support by the Open Access publication fund of Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung. None of the funding bodies was involved in the design of the study, the collection, analysis, and interpretation of data or in writing the manuscript. Open Access funding enabled and organized by Projekt DEAL.","day":"01","OA_type":"gold","doi":"10.1038/s41467-025-65631-0","OA_place":"publisher","department":[{"_id":"GradSch"}],"volume":16,"scopus_import":"1","quality_controlled":"1","type":"journal_article","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41467-025-65631-0"}],"abstract":[{"text":"Camera-type eyes in vertebrates and cephalopods are striking examples of parallel evolution of a complex structure. While comparisons have focused on these two groups, camera-type eyes with likely high functionality are also found in other invertebrate phyla with simpler brains. Employing single-cell RNA sequencing, we identify neurogenic cells in the adult eyes and brain of the marine annelid worm Platynereis dumerilii. Distinct neural stem cells in the camera-type adult eyes, located at the edge of the cup-shaped retina, and adjacent to the glass body/lens, produce radial lines of cells, reminiscent of stem cells in ciliary marginal zones of vertebrate eyes exhibiting life-long growth. Normal proliferation in the eye depends on ambient light, a phenomenon that depends on the integrity of the photoreceptor gene c-opsin1, which is present in emerging rhabdomeric photoreceptors, and impacts on their differentiation. During reproductive maturation, proliferation in the eye as well as the entire brain sharply declines, while cells upregulate molecular characteristics of mammalian adult neural stem cell quiescence. Our data provide insights into the development and modulation of annelid head and brain cells, revealing similarities and differences to vertebrate eye development, neurogenesis and brain plasticity.","lang":"eng"}]},{"author":[{"first_name":"Xiaofei","last_name":"Gao","full_name":"Gao, Xiaofei"},{"full_name":"Li, Jun-Liszt","first_name":"Jun-Liszt","last_name":"Li"},{"full_name":"Chen, Xingjun","last_name":"Chen","first_name":"Xingjun"},{"first_name":"Bo","last_name":"Ci","full_name":"Ci, Bo"},{"last_name":"Chen","first_name":"Fei","full_name":"Chen, Fei"},{"last_name":"Lu","first_name":"Nannan","full_name":"Lu, Nannan"},{"first_name":"Bo","last_name":"Shen","full_name":"Shen, Bo"},{"first_name":"Lijun","last_name":"Zheng","full_name":"Zheng, Lijun"},{"full_name":"Jia, Jie-Min","last_name":"Jia","first_name":"Jie-Min"},{"first_name":"Yating","last_name":"Yi","full_name":"Yi, Yating"},{"full_name":"Zhang, Shiwen","first_name":"Shiwen","last_name":"Zhang"},{"last_name":"Shi","first_name":"Ying-Chao","full_name":"Shi, Ying-Chao"},{"full_name":"Shi, Kaibin","first_name":"Kaibin","last_name":"Shi"},{"first_name":"Nicholas E","last_name":"Propson","full_name":"Propson, Nicholas E"},{"full_name":"Huang, Yubin","first_name":"Yubin","last_name":"Huang"},{"full_name":"Poinsatte, Katherine","first_name":"Katherine","last_name":"Poinsatte"},{"full_name":"Zhang, Zhaohuan","first_name":"Zhaohuan","last_name":"Zhang"},{"last_name":"Yue","first_name":"Yuanlei","full_name":"Yue, Yuanlei"},{"full_name":"Bosco, Dale B","last_name":"Bosco","first_name":"Dale B"},{"last_name":"Lu","first_name":"Ying-mei","full_name":"Lu, Ying-mei"},{"full_name":"Yang, Shi-bing","first_name":"Shi-bing","last_name":"Yang"},{"last_name":"Adams","first_name":"Ralf H.","full_name":"Adams, Ralf H."},{"first_name":"Volkhard","last_name":"Lindner","full_name":"Lindner, Volkhard"},{"full_name":"Huang, Fen","first_name":"Fen","last_name":"Huang"},{"first_name":"Long-Jun","last_name":"Wu","full_name":"Wu, Long-Jun"},{"full_name":"Zheng, Hui","last_name":"Zheng","first_name":"Hui"},{"first_name":"Feng","last_name":"Han","full_name":"Han, Feng"},{"first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","last_name":"Hippenmeyer","orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon"},{"full_name":"Stowe, Ann M.","last_name":"Stowe","first_name":"Ann M."},{"last_name":"Peng","first_name":"Bo","full_name":"Peng, Bo"},{"last_name":"Margeta","first_name":"Marta","full_name":"Margeta, Marta"},{"last_name":"Wang","first_name":"Xiaoqun","full_name":"Wang, Xiaoqun"},{"last_name":"Liu","first_name":"Qiang","full_name":"Liu, Qiang"},{"full_name":"Körbelin, Jakob","last_name":"Körbelin","first_name":"Jakob"},{"full_name":"Trepel, Martin","first_name":"Martin","last_name":"Trepel"},{"last_name":"Lu","first_name":"Hui","full_name":"Lu, Hui"},{"full_name":"Zhou, Bo O.","last_name":"Zhou","first_name":"Bo O."},{"first_name":"Hu","last_name":"Zhao","full_name":"Zhao, Hu"},{"last_name":"Su","first_name":"Wenzhi","full_name":"Su, Wenzhi"},{"first_name":"Robert M.","last_name":"Bachoo","full_name":"Bachoo, Robert M."},{"first_name":"Woo-ping","last_name":"Ge","full_name":"Ge, Woo-ping"}],"publisher":"Springer Nature","oa_version":"Published Version","month":"07","isi":1,"year":"2025","article_type":"original","citation":{"ista":"Gao X, Li J-L, Chen X, Ci B, Chen F, Lu N, Shen B, Zheng L, Jia J-M, Yi Y, Zhang S, Shi Y-C, Shi K, Propson NE, Huang Y, Poinsatte K, Zhang Z, Yue Y, Bosco DB, Lu Y, Yang S, Adams RH, Lindner V, Huang F, Wu L-J, Zheng H, Han F, Hippenmeyer S, Stowe AM, Peng B, Margeta M, Wang X, Liu Q, Körbelin J, Trepel M, Lu H, Zhou BO, Zhao H, Su W, Bachoo RM, Ge W. 2025. Reduction of neuronal activity mediated by blood-vessel regression in the brain. Nature Communications. 16, 5840.","short":"X. Gao, J.-L. Li, X. Chen, B. Ci, F. Chen, N. Lu, B. Shen, L. Zheng, J.-M. Jia, Y. Yi, S. Zhang, Y.-C. Shi, K. Shi, N.E. Propson, Y. Huang, K. Poinsatte, Z. Zhang, Y. Yue, D.B. Bosco, Y. Lu, S. Yang, R.H. Adams, V. Lindner, F. Huang, L.-J. Wu, H. Zheng, F. Han, S. Hippenmeyer, A.M. Stowe, B. Peng, M. Margeta, X. Wang, Q. Liu, J. Körbelin, M. Trepel, H. Lu, B.O. Zhou, H. Zhao, W. Su, R.M. Bachoo, W. Ge, Nature Communications 16 (2025).","apa":"Gao, X., Li, J.-L., Chen, X., Ci, B., Chen, F., Lu, N., … Ge, W. (2025). Reduction of neuronal activity mediated by blood-vessel regression in the brain. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-60308-0\">https://doi.org/10.1038/s41467-025-60308-0</a>","chicago":"Gao, Xiaofei, Jun-Liszt Li, Xingjun Chen, Bo Ci, Fei Chen, Nannan Lu, Bo Shen, et al. “Reduction of Neuronal Activity Mediated by Blood-Vessel Regression in the Brain.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-025-60308-0\">https://doi.org/10.1038/s41467-025-60308-0</a>.","ama":"Gao X, Li J-L, Chen X, et al. Reduction of neuronal activity mediated by blood-vessel regression in the brain. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-025-60308-0\">10.1038/s41467-025-60308-0</a>","mla":"Gao, Xiaofei, et al. “Reduction of Neuronal Activity Mediated by Blood-Vessel Regression in the Brain.” <i>Nature Communications</i>, vol. 16, 5840, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-60308-0\">10.1038/s41467-025-60308-0</a>.","ieee":"X. Gao <i>et al.</i>, “Reduction of neuronal activity mediated by blood-vessel regression in the brain,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025."},"article_processing_charge":"Yes","_id":"8616","date_published":"2025-07-01T00:00:00Z","oa":1,"date_created":"2020-10-06T08:58:59Z","date_updated":"2025-09-04T07:08:37Z","DOAJ_listed":"1","intvolume":"        16","article_number":"5840","project":[{"call_identifier":"H2020","_id":"260018B0-B435-11E9-9278-68D0E5697425","grant_number":"725780","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development"}],"language":[{"iso":"eng"}],"publication_identifier":{"eissn":["2041-1723"]},"status":"public","external_id":{"isi":["001523450500035"]},"publication":"Nature Communications","ddc":["570"],"title":"Reduction of neuronal activity mediated by blood-vessel regression in the brain","acknowledgement":"The project was initiated in the Jan lab at UCSF. We thank Lily Jan and Yuh-Nung Jan’s generous support. We thank Liqun Luo’s lab for providing MADM-7 mice and Rolf A Brekken for VEGF-antibodies.  Drs. Yuanquan Song (UPenn), Zhaozhu Hu (JHU), Ji Hu (ShanghaiTech), Yang Xiang (U. Mass), Hao Wang (Zhejiang U.) and Ruikang Wang (U. Washington) for critical input, colleagues at Children’s Research Institute, Departments of Neuroscience, Neurology and Neurotherapeutics, Pediatrics from UT Southwestern, and colleagues from the Jan lab for discussion. Dr. Bridget Samuels, Sean Morrison (UT Southwestern), and Nannan Lu (Zhejiang U.) for critical reading. We acknowledge the assistance of the CIBR Imaging core. We also thank UT Southwestern Live Cell Imaging Facility, a Shared Resource of the Harold C. Simmons Cancer Center, supported in part by an NCI Cancer Center Support Grant, P30 CA142543K. This work is supported by CIBR funds and the American Heart Association AWRP Summer 2016 Innovative Research Grant (17IRG33410377) to W-P.G.; National Natural Science Foundation of China (No.81370031) to Z.Z.;National Key Research and Development Program of China (2016YFE0125400)to F.H.;National Natural Science Foundations of China (No. 81473202) to Y.L.; National Natural Science Foundation of China (No.31600839) and Shenzhen Science and Technology Research Program (JCYJ20170818163320865) to B.P.; National Natural Science Foundation of China (No. 31800864) and Westlake University start-up funds to J-M. J. NIH R01NS088627 to W.L.J.; NIH: R01 AG020670 and RF1AG054111 to H.Z.; R01 NS088555 to A.M.S., and European Research Council No.725780 to S.H.;W-P.G. was a recipient of Bugher-American Heart Association Dan Adams Thinking Outside the Box Award.","day":"01","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"publication_status":"published","doi":"10.1038/s41467-025-60308-0","OA_type":"gold","file_date_updated":"2025-07-07T09:52:46Z","department":[{"_id":"SiHi"}],"OA_place":"publisher","file":[{"creator":"dernst","success":1,"content_type":"application/pdf","date_updated":"2025-07-07T09:52:46Z","date_created":"2025-07-07T09:52:46Z","file_name":"2025_NatureComm_Gao.pdf","checksum":"f59748cb67232cfb210035d9aef60836","access_level":"open_access","file_size":17018106,"file_id":"19971","relation":"main_file"}],"ec_funded":1,"quality_controlled":"1","type":"journal_article","scopus_import":"1","volume":16,"abstract":[{"text":"The brain vasculature supplies neurons with glucose and oxygen, but little is known about how vascular plasticity contributes to brain function. Using longitudinal in vivo imaging, we report that a substantial proportion of blood vessels in the adult mouse brain sporadically occlude and regress. Their regression proceeds through sequential stages of blood-flow occlusion, endothelial cell collapse, relocation or loss of pericytes, and retraction of glial endfeet. Regressing vessels are found to be widespread in mouse, monkey and human brains. We further reveal that blood vessel regression cause a reduction of neuronal activity due to a dysfunction in mitochondrial metabolism and glutamate production. Our results elucidate the mechanism of vessel regression and its role in neuronal function in the adult brain.","lang":"eng"}],"has_accepted_license":"1"},{"doi":"10.1038/s41467-025-60953-5","OA_type":"gold","OA_place":"publisher","ddc":["530"],"publication":"Nature Communications","title":"Large-scale self-assembled nanophotonic scintillators for X-ray imaging","extern":"1","day":"01","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"abstract":[{"lang":"eng","text":"Scintillators convert X-ray energy into visible light and are critical for imaging technologies. Their widespread use relies on scalable, high-quality manufacturing methods. Nanophotonic scintillators, featuring wavelength-scale nanostructures, can offer improved emission properties such as higher light yield, shorter decay times, and enhanced directionality. However, achieving scalable fabrication of these structures remains challenging. Here, we present a scalable fabrication method for large-area nanophotonic scintillators based on the self-assembly of chalcogenide glass photonic crystals. This technique enables the production of nanophotonic scintillators over wafer-scale areas, achieving a six-fold enhancement in light yield compared to unpatterned scintillators. By studying surface nanofabrication disorder, we show its impact on imaging performance and provide a route towards scintillation enhancements without compromising resolution. We demonstrate the practical applicability of our nanophotonic scintillators through X-ray imaging of biological and inorganic specimens. Our results could enable the industrial implementation of a new generation of nanophotonic-enhanced scintillators."}],"main_file_link":[{"url":"https://doi.org/10.1038/s41467-025-60953-5"}],"scopus_import":"1","type":"journal_article","quality_controlled":"1","volume":16,"article_processing_charge":"No","citation":{"ama":"Martin-Monier L, Pajovic S, Abebe MG, et al. Large-scale self-assembled nanophotonic scintillators for X-ray imaging. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-025-60953-5\">10.1038/s41467-025-60953-5</a>","mla":"Martin-Monier, Louis, et al. “Large-Scale Self-Assembled Nanophotonic Scintillators for X-Ray Imaging.” <i>Nature Communications</i>, vol. 16, 5750, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-60953-5\">10.1038/s41467-025-60953-5</a>.","ieee":"L. Martin-Monier <i>et al.</i>, “Large-scale self-assembled nanophotonic scintillators for X-ray imaging,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025.","apa":"Martin-Monier, L., Pajovic, S., Abebe, M. G., Chen, J., Vaidya, S., Min, S., … Roques-Carmes, C. (2025). Large-scale self-assembled nanophotonic scintillators for X-ray imaging. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-60953-5\">https://doi.org/10.1038/s41467-025-60953-5</a>","chicago":"Martin-Monier, Louis, Simo Pajovic, Muluneh G. Abebe, Joshua Chen, Sachin Vaidya, Seokhwan Min, Seou Choi, et al. “Large-Scale Self-Assembled Nanophotonic Scintillators for X-Ray Imaging.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-025-60953-5\">https://doi.org/10.1038/s41467-025-60953-5</a>.","short":"L. Martin-Monier, S. Pajovic, M.G. Abebe, J. Chen, S. Vaidya, S. Min, S. Choi, S.E. Kooi, B. Maes, J. Hu, M. Soljačić, C. Roques-Carmes, Nature Communications 16 (2025).","ista":"Martin-Monier L, Pajovic S, Abebe MG, Chen J, Vaidya S, Min S, Choi S, Kooi SE, Maes B, Hu J, Soljačić M, Roques-Carmes C. 2025. Large-scale self-assembled nanophotonic scintillators for X-ray imaging. Nature Communications. 16, 5750."},"date_published":"2025-07-01T00:00:00Z","_id":"21541","date_updated":"2026-04-27T07:17:31Z","date_created":"2026-03-30T12:22:47Z","DOAJ_listed":"1","author":[{"first_name":"Louis","last_name":"Martin-Monier","full_name":"Martin-Monier, Louis"},{"full_name":"Pajovic, Simo","first_name":"Simo","last_name":"Pajovic"},{"full_name":"Abebe, Muluneh G.","last_name":"Abebe","first_name":"Muluneh G."},{"full_name":"Chen, Joshua","last_name":"Chen","first_name":"Joshua"},{"last_name":"Vaidya","first_name":"Sachin","full_name":"Vaidya, Sachin"},{"last_name":"Min","first_name":"Seokhwan","full_name":"Min, Seokhwan"},{"last_name":"Choi","first_name":"Seou","full_name":"Choi, Seou"},{"full_name":"Kooi, Steven E.","first_name":"Steven E.","last_name":"Kooi"},{"full_name":"Maes, Bjorn","first_name":"Bjorn","last_name":"Maes"},{"first_name":"Juejun","last_name":"Hu","full_name":"Hu, Juejun"},{"last_name":"Soljačić","first_name":"Marin","full_name":"Soljačić, Marin"},{"first_name":"Charles","id":"e2e68fc9-6505-11ef-a541-eb4e72cc3e82","last_name":"Roques-Carmes","full_name":"Roques-Carmes, Charles"}],"publisher":"Springer Nature","oa_version":"Published Version","month":"07","year":"2025","article_type":"original","publication_identifier":{"eissn":["2041-1723"]},"status":"public","language":[{"iso":"eng"}],"external_id":{"arxiv":["2410.07141"]},"intvolume":"        16","article_number":"5750","arxiv":1},{"external_id":{"pmid":["40813397"],"arxiv":["2412.01772"]},"language":[{"iso":"eng"}],"publication_identifier":{"eissn":["2041-1723"]},"status":"public","intvolume":"        16","arxiv":1,"article_number":"7576","oa":1,"date_created":"2026-03-30T12:22:47Z","date_updated":"2026-04-27T08:37:35Z","DOAJ_listed":"1","article_processing_charge":"No","citation":{"ieee":"S. Choi, Y. Salamin, C. Roques-Carmes, J. Sloan, M. Horodynski, and M. Soljačić, “Observing the dynamics of quantum states generated inside nonlinear optical cavities,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025.","mla":"Choi, Seou, et al. “Observing the Dynamics of Quantum States Generated inside Nonlinear Optical Cavities.” <i>Nature Communications</i>, vol. 16, 7576, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-63035-8\">10.1038/s41467-025-63035-8</a>.","ama":"Choi S, Salamin Y, Roques-Carmes C, Sloan J, Horodynski M, Soljačić M. Observing the dynamics of quantum states generated inside nonlinear optical cavities. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-025-63035-8\">10.1038/s41467-025-63035-8</a>","chicago":"Choi, Seou, Yannick Salamin, Charles Roques-Carmes, Jamison Sloan, Michael Horodynski, and Marin Soljačić. “Observing the Dynamics of Quantum States Generated inside Nonlinear Optical Cavities.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-025-63035-8\">https://doi.org/10.1038/s41467-025-63035-8</a>.","apa":"Choi, S., Salamin, Y., Roques-Carmes, C., Sloan, J., Horodynski, M., &#38; Soljačić, M. (2025). Observing the dynamics of quantum states generated inside nonlinear optical cavities. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-63035-8\">https://doi.org/10.1038/s41467-025-63035-8</a>","short":"S. Choi, Y. Salamin, C. Roques-Carmes, J. Sloan, M. Horodynski, M. Soljačić, Nature Communications 16 (2025).","ista":"Choi S, Salamin Y, Roques-Carmes C, Sloan J, Horodynski M, Soljačić M. 2025. Observing the dynamics of quantum states generated inside nonlinear optical cavities. Nature Communications. 16, 7576."},"_id":"21543","date_published":"2025-08-14T00:00:00Z","year":"2025","article_type":"original","author":[{"first_name":"Seou","last_name":"Choi","full_name":"Choi, Seou"},{"full_name":"Salamin, Yannick","last_name":"Salamin","first_name":"Yannick"},{"last_name":"Roques-Carmes","id":"e2e68fc9-6505-11ef-a541-eb4e72cc3e82","first_name":"Charles","full_name":"Roques-Carmes, Charles"},{"first_name":"Jamison","last_name":"Sloan","full_name":"Sloan, Jamison"},{"full_name":"Horodynski, Michael","first_name":"Michael","last_name":"Horodynski"},{"last_name":"Soljačić","first_name":"Marin","full_name":"Soljačić, Marin"}],"publisher":"Springer Nature","oa_version":"Published Version","month":"08","abstract":[{"text":"Observing non-classical properties of light is a long-standing interest to advance a wide range of quantum applications. Optical cavities are essential to generate and manipulate non-classical light. However, detecting changes in cavity properties induced by the quantum state remains a critical challenge in the optical domain due to the weak material nonlinearity. Here, we propose a framework for observing the dynamics of quantum states generated inside nonlinear optical cavities. We leverage the symmetry-breaking process of a bistable system, which is highly sensitive to the initial state, enabling detection of quantum state displacement through an asymmetric equilibrium of a macroscopic observable. With a nonlinear response at the single photon level, our approach directly imprints the cavity field distribution onto the statistics of bistable cavity steady-states. We experimentally demonstrate our approach in a degenerate optical parametric oscillator, generating and reconstructing different quantum states. As a validation, we reconstruct the Husimi Q function of the cavity squeezed vacuum state. In addition, we observe the evolution of the quantum vacuum state inside the cavity as it undergoes phase-sensitive amplification. By enabling generation and measurement of quantum states in a single nonlinear optical cavity, our method paves a way for studying exotic dynamics of quantum optical states in nonlinear driven-dissipative systems.","lang":"eng"}],"main_file_link":[{"url":"https://doi.org/10.1038/s41467-025-63035-8","open_access":"1"}],"type":"journal_article","quality_controlled":"1","scopus_import":"1","volume":16,"OA_place":"publisher","doi":"10.1038/s41467-025-63035-8","OA_type":"gold","pmid":1,"day":"14","tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","publication":"Nature Communications","ddc":["530"],"title":"Observing the dynamics of quantum states generated inside nonlinear optical cavities","extern":"1"},{"year":"2025","article_type":"original","author":[{"last_name":"Pontula","first_name":"Sahil","full_name":"Pontula, Sahil"},{"full_name":"Vaidya, Sachin","first_name":"Sachin","last_name":"Vaidya"},{"full_name":"Roques-Carmes, Charles","last_name":"Roques-Carmes","id":"e2e68fc9-6505-11ef-a541-eb4e72cc3e82","first_name":"Charles"},{"first_name":"Shiekh Zia","last_name":"Uddin","full_name":"Uddin, Shiekh Zia"},{"full_name":"Soljačić, Marin","last_name":"Soljačić","first_name":"Marin"},{"full_name":"Salamin, Yannick","last_name":"Salamin","first_name":"Yannick"}],"oa_version":"Published Version","month":"08","publisher":"Springer Nature","date_updated":"2026-04-27T10:06:42Z","date_created":"2026-03-30T12:22:47Z","oa":1,"DOAJ_listed":"1","citation":{"short":"S. Pontula, S. Vaidya, C. Roques-Carmes, S.Z. Uddin, M. Soljačić, Y. Salamin, Nature Communications 16 (2025).","ista":"Pontula S, Vaidya S, Roques-Carmes C, Uddin SZ, Soljačić M, Salamin Y. 2025. Non-reciprocal frequency conversion in a non-Hermitian multimode nonlinear system. Nature Communications. 16, 7544.","mla":"Pontula, Sahil, et al. “Non-Reciprocal Frequency Conversion in a Non-Hermitian Multimode Nonlinear System.” <i>Nature Communications</i>, vol. 16, 7544, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-62853-0\">10.1038/s41467-025-62853-0</a>.","ieee":"S. Pontula, S. Vaidya, C. Roques-Carmes, S. Z. Uddin, M. Soljačić, and Y. Salamin, “Non-reciprocal frequency conversion in a non-Hermitian multimode nonlinear system,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025.","ama":"Pontula S, Vaidya S, Roques-Carmes C, Uddin SZ, Soljačić M, Salamin Y. Non-reciprocal frequency conversion in a non-Hermitian multimode nonlinear system. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-025-62853-0\">10.1038/s41467-025-62853-0</a>","chicago":"Pontula, Sahil, Sachin Vaidya, Charles Roques-Carmes, Shiekh Zia Uddin, Marin Soljačić, and Yannick Salamin. “Non-Reciprocal Frequency Conversion in a Non-Hermitian Multimode Nonlinear System.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-025-62853-0\">https://doi.org/10.1038/s41467-025-62853-0</a>.","apa":"Pontula, S., Vaidya, S., Roques-Carmes, C., Uddin, S. Z., Soljačić, M., &#38; Salamin, Y. (2025). Non-reciprocal frequency conversion in a non-Hermitian multimode nonlinear system. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-62853-0\">https://doi.org/10.1038/s41467-025-62853-0</a>"},"article_processing_charge":"No","date_published":"2025-08-14T00:00:00Z","_id":"21542","intvolume":"        16","article_number":"7544","external_id":{"pmid":["40813767"]},"publication_identifier":{"eissn":["2041-1723"]},"status":"public","language":[{"iso":"eng"}],"day":"14","publication_status":"published","tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","extern":"1","publication":"Nature Communications","title":"Non-reciprocal frequency conversion in a non-Hermitian multimode nonlinear system","ddc":["530"],"OA_place":"publisher","doi":"10.1038/s41467-025-62853-0","OA_type":"gold","pmid":1,"scopus_import":"1","type":"journal_article","quality_controlled":"1","volume":16,"abstract":[{"lang":"eng","text":"Nonlinear optics has become the workhorse for countless applications in classical and quantum optics, from optical bistability to single photon pair generation. However, the intrinsic weakness of optical nonlinearity and reciprocity of nonlinear interactions generally places stringent limits on the efficiency of nonlinear optical processes and their ability to be tailored for advanced applications in multimode systems. Here, motivated by recent advances in using non-Hermitian photonics and gain/loss engineering to enable non-reciprocal light transport, we explore how the interplay between non-Hermiticity and optical nonlinearity leads to a fundamentally new regime of nonlinear frequency conversion. We show how non-Hermitian coupling between discrete frequency modes can result in non-reciprocal flow of energy in a frequency dimension, closely resembling the non-Hermitian skin effect (NHSE). Applying our theory to a multimode nonlinear cavity supporting cascaded nonlinear processes, we demonstrate chiral energy flow in a frequency dimension, leading to long-range frequency shifts of quasi-continuous wave sources, shaped frequency combs robust to defects and disorder, terahertz (THz) generation far exceeding the Manley-Rowe limit, and nonlinear multimodal limit cycles for multi-frequency pump-probe spectroscopy."}],"main_file_link":[{"url":"https://doi.org/10.1038/s41467-025-62853-0","open_access":"1"}]}]