---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21158'
abstract:
- lang: eng
text: Vernalization-regulated flowering is vital for wheat yield and geographical
distribution, and the diversity of flowering time genes is essential for the breeding
of climate-resilient varieties. Sugars have long been recognized in regulating
flowering; however, the intrinsic connection between carbohydrate metabolism and
vernalization response remains largely unexplored. Here, we identify a fructose
1,6-bisphosphate aldolase (FBA) encoding gene, HtL1/FBA10, as a modulator of heading
time variation based on a genome-wide association study utilizing wheat core germplasm
collections. Evolutionary analysis shows a decrease in the proportion of haplotype-2
of HtL1, which is linked to delayed flowering, in Chinese and American wheat varieties
compared to landraces. Vernalization reduces HtL1/FBA10 phosphorylation levels
and increases its O-GlcNAcylation, which in turn enhances its enzymatic activity
and facilitates VERNALIZATION 1 (VRN1) transcription by regulating histone acetylation
at the VRN1 locus. Our findings provide mechanistic insights into the interplay
between glucose metabolism and the epigenetic regulation of vernalization in winter
wheat.
acknowledgement: This work was supported by the Basic Science Center Project of National
Natural Science Foundation of China (32388201) to K.C and the National Natural Science
Foundation of China (31970331) to L.X. We thank Dr. Zhuang Lu, Dr. Bin Han and Ms.
Jingquan Li (Plant Science Facility of the Institute of Botany, Chinese Academy
of Sciences) for their technical assistance in LC-MS/MS assay, small molecule compound
analysis and the subcellular localization assay, respectively. We thank Dr. Wei
Luo and Dr. Dongfeng Liu for helpful discussions.
article_number: '999'
article_processing_charge: Yes
article_type: original
author:
- first_name: Pengfang
full_name: Yang, Pengfang
last_name: Yang
- first_name: Yangyang
full_name: Liu, Yangyang
last_name: Liu
- first_name: Qi
full_name: Dong, Qi
last_name: Dong
- first_name: Yuting
full_name: Miao, Yuting
last_name: Miao
- first_name: Jianlong
full_name: Zhang, Jianlong
last_name: Zhang
- first_name: Shujuan
full_name: Xu, Shujuan
id: 9724dd9d-f591-11ee-bd51-e97ed0652286
last_name: Xu
- first_name: Hong
full_name: Zhao, Hong
last_name: Zhao
- first_name: Yuda
full_name: Niu, Yuda
last_name: Niu
- first_name: Xueyong
full_name: Zhang, Xueyong
last_name: Zhang
- first_name: Yunyuan
full_name: Xu, Yunyuan
last_name: Xu
- first_name: Zifeng
full_name: Guo, Zifeng
last_name: Guo
- first_name: Lijing
full_name: Xing, Lijing
last_name: Xing
- first_name: Kang
full_name: Chong, Kang
last_name: Chong
citation:
ama: Yang P, Liu Y, Dong Q, et al. O-GlcNAc and phosphorylation modifications on
HtL1/FBA10 regulate wheat vernalization for flowering. Nature Communications.
2026;17. doi:10.1038/s41467-025-67734-0
apa: Yang, P., Liu, Y., Dong, Q., Miao, Y., Zhang, J., Xu, S., … Chong, K. (2026).
O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization
for flowering. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-025-67734-0
chicago: Yang, Pengfang, Yangyang Liu, Qi Dong, Yuting Miao, Jianlong Zhang, Shujuan
Xu, Hong Zhao, et al. “O-GlcNAc and Phosphorylation Modifications on HtL1/FBA10
Regulate Wheat Vernalization for Flowering.” Nature Communications. Springer
Nature, 2026. https://doi.org/10.1038/s41467-025-67734-0.
ieee: P. Yang et al., “O-GlcNAc and phosphorylation modifications on HtL1/FBA10
regulate wheat vernalization for flowering,” Nature Communications, vol.
17. Springer Nature, 2026.
ista: Yang P, Liu Y, Dong Q, Miao Y, Zhang J, Xu S, Zhao H, Niu Y, Zhang X, Xu Y,
Guo Z, Xing L, Chong K. 2026. O-GlcNAc and phosphorylation modifications on HtL1/FBA10
regulate wheat vernalization for flowering. Nature Communications. 17, 999.
mla: Yang, Pengfang, et al. “O-GlcNAc and Phosphorylation Modifications on HtL1/FBA10
Regulate Wheat Vernalization for Flowering.” Nature Communications, vol.
17, 999, Springer Nature, 2026, doi:10.1038/s41467-025-67734-0.
short: P. Yang, Y. Liu, Q. Dong, Y. Miao, J. Zhang, S. Xu, H. Zhao, Y. Niu, X. Zhang,
Y. Xu, Z. Guo, L. Xing, K. Chong, Nature Communications 17 (2026).
date_created: 2026-02-08T23:02:48Z
date_published: 2026-01-27T00:00:00Z
date_updated: 2026-02-12T14:34:24Z
day: '27'
ddc:
- '580'
department:
- _id: XiFe
doi: 10.1038/s41467-025-67734-0
external_id:
pmid:
- '41455723'
file:
- access_level: open_access
checksum: 9ae170ec70ba1ab56b6f1ffe67d1de7f
content_type: application/pdf
creator: dernst
date_created: 2026-02-12T14:33:14Z
date_updated: 2026-02-12T14:33:14Z
file_id: '21223'
file_name: 2026_NatureComm_Yang.pdf
file_size: 4685882
relation: main_file
success: 1
file_date_updated: 2026-02-12T14:33:14Z
has_accepted_license: '1'
intvolume: ' 17'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization
for flowering
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21369'
abstract:
- lang: eng
text: 'Formation of new amyloid fibrils and oligomers from monomeric protein on
the surfaces of existing fibrils is an important driver of many disorders such
as Alzheimer’s and Parkinson’s diseases. The structural basis of this secondary
nucleation process, however, is poorly understood. Here, we ask whether secondary
nucleation sites are found predominantly at rare growth defects: irregularities
in the fibril core structure incorporated during their original assembly. We first
demonstrate using the specific inhibitor of secondary nucleation, Brichos, that
secondary nucleation sites on Alzheimer’s disease-associated fibrils composed
of Aβ40 and Aβ42 peptides are rare compared to the number of protein molecules
they contain. We then grow Aβ40 fibrils under conditions designed to eliminate
most growth defects while leaving the regular fibril morphology unchanged, and
confirm the latter using cryo-electron microscopy. We measure both the ability
of these annealed fibrils to promote secondary nucleation and the stoichiometry
of their secondary nucleation sites, finding that both are greatly reduced as
predicted. Re-analysis of published data for other proteins suggests that fibril
growth defects may also drive secondary nucleation generally across most amyloids.
These findings could unlock structure-based drug design of therapeutics that aim
to halt amyloid disorders by inhibiting secondary nucleation sites.'
acknowledgement: This work was supported by the Swedish Research Council (2019-02397
to E.S., 2015-00143 to S.L., and 2022-06641 to S.L. and E.S.), and the GenerationNano
project, the European Union’s Horizon 2020 research and innovation programme under
the Marie Skłodowska-Curie grant agreement No 945378 (S.L. co-PI). We acknowledge
support from the Wellcome Trust (T.P.J.K.), the Cambridge Centre for Misfolding
Diseases (T.P.J.K.), the BBSRC (T.P.J.K.), the Frances and Augustus Newman Foundation
(T.P.J.K.), the ERC PhysProt (agreement n 337969) (T.S., T.P.J.K., S.L.), ETC StG
“NEPA” (A.Š. and S.C.), the Royal Society (S.C., A.S.), the ERASMUS Programme (T.S.),
and The Danish Council for Independent Research ∣ Natural Sciences (FNU-11-113326)
(M.A.). This work was also funded by the Novo Nordisk Foundation (#NNF19OC0054635
to S.L.), ETH Zürich (T.C.T.M.), and the Swiss National Science Foundation (grant
no 219703 to A.J.D. and T.C.T.M.). We acknowledge the use of the nano-Characterisation
and nano-Manufacturing Research Equipment (nCHREM) facility for access to microscopy
instrumentation. We are grateful to the late Professor Sir Christopher Dobson for
invaluable conversations regarding the microfluidic diffusional sizing experiments.
We are also grateful to Quentin A. E. Peter and Thomas Müller for their guidance
on microfluidic device design. The cuvette-filled icon in Fig. 3d is by Servier
[https://smart.servier.com/]. It is licensed under CC-BY 3.0 Unported [https://creativecommons.org/licenses/by/3.0/].
The authors would like to acknowledge Umeå Centre for Electron Microscopy (UCEM)
for technical assistance and access to electron microscopy. Support was provided
by SciLifeLab national Cryo-EM Unit at Umeå University.
article_number: '1933'
article_processing_charge: Yes
article_type: original
author:
- first_name: Jing
full_name: Hu, Jing
last_name: Hu
- first_name: Tom
full_name: Scheidt, Tom
last_name: Scheidt
- first_name: Dev
full_name: Thacker, Dev
last_name: Thacker
- first_name: Emil
full_name: Axell, Emil
last_name: Axell
- first_name: Elin
full_name: Stemme, Elin
last_name: Stemme
- first_name: Urszula
full_name: Łapińska, Urszula
last_name: Łapińska
- first_name: Stefan
full_name: Wennmalm, Stefan
last_name: Wennmalm
- first_name: Georg
full_name: Meisl, Georg
last_name: Meisl
- first_name: Samo
full_name: Curk, Samo
id: 031eff0d-d481-11ee-8508-cd12a7a86e5b
last_name: Curk
orcid: 0000-0001-6160-9766
- first_name: Maria
full_name: Andreasen, Maria
last_name: Andreasen
- first_name: Michele
full_name: Vendruscolo, Michele
last_name: Vendruscolo
- first_name: Paolo
full_name: Arosio, Paolo
last_name: Arosio
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Jeremy D.
full_name: Schmit, Jeremy D.
last_name: Schmit
- first_name: Tuomas P.J.
full_name: Knowles, Tuomas P.J.
last_name: Knowles
- first_name: Emma
full_name: Sparr, Emma
last_name: Sparr
- first_name: Sara
full_name: Linse, Sara
last_name: Linse
- first_name: Thomas C.T.
full_name: Michaels, Thomas C.T.
last_name: Michaels
- first_name: Alexander J.
full_name: Dear, Alexander J.
last_name: Dear
citation:
ama: Hu J, Scheidt T, Thacker D, et al. Structural defects in amyloid-β fibrils
drive secondary nucleation. Nature Communications. 2026;17. doi:10.1038/s41467-026-69377-1
apa: Hu, J., Scheidt, T., Thacker, D., Axell, E., Stemme, E., Łapińska, U., … Dear,
A. J. (2026). Structural defects in amyloid-β fibrils drive secondary nucleation.
Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-026-69377-1
chicago: Hu, Jing, Tom Scheidt, Dev Thacker, Emil Axell, Elin Stemme, Urszula Łapińska,
Stefan Wennmalm, et al. “Structural Defects in Amyloid-β Fibrils Drive Secondary
Nucleation.” Nature Communications. Springer Nature, 2026. https://doi.org/10.1038/s41467-026-69377-1.
ieee: J. Hu et al., “Structural defects in amyloid-β fibrils drive secondary
nucleation,” Nature Communications, vol. 17. Springer Nature, 2026.
ista: Hu J, Scheidt T, Thacker D, Axell E, Stemme E, Łapińska U, Wennmalm S, Meisl
G, Curk S, Andreasen M, Vendruscolo M, Arosio P, Šarić A, Schmit JD, Knowles TPJ,
Sparr E, Linse S, Michaels TCT, Dear AJ. 2026. Structural defects in amyloid-β
fibrils drive secondary nucleation. Nature Communications. 17, 1933.
mla: Hu, Jing, et al. “Structural Defects in Amyloid-β Fibrils Drive Secondary Nucleation.”
Nature Communications, vol. 17, 1933, Springer Nature, 2026, doi:10.1038/s41467-026-69377-1.
short: J. Hu, T. Scheidt, D. Thacker, E. Axell, E. Stemme, U. Łapińska, S. Wennmalm,
G. Meisl, S. Curk, M. Andreasen, M. Vendruscolo, P. Arosio, A. Šarić, J.D. Schmit,
T.P.J. Knowles, E. Sparr, S. Linse, T.C.T. Michaels, A.J. Dear, Nature Communications
17 (2026).
date_created: 2026-03-01T23:01:38Z
date_published: 2026-02-20T00:00:00Z
date_updated: 2026-03-02T09:36:48Z
day: '20'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1038/s41467-026-69377-1
ec_funded: 1
external_id:
pmid:
- '41708600'
file:
- access_level: open_access
checksum: fa2b55b3a0d8978de7d2d061c7ad8779
content_type: application/pdf
creator: dernst
date_created: 2026-03-02T09:34:18Z
date_updated: 2026-03-02T09:34:18Z
file_id: '21377'
file_name: 2026_NatureComm_Hu.pdf
file_size: 4821073
relation: main_file
success: 1
file_date_updated: 2026-03-02T09:34:18Z
has_accepted_license: '1'
intvolume: ' 17'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
call_identifier: H2020
grant_number: '802960'
name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Structural defects in amyloid-β fibrils drive secondary nucleation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21382'
abstract:
- lang: eng
text: The exceptional energy-harvesting efficiency of lead-halide perovskites arises
from unusually long photocarrier diffusion lengths and recombination lifetimes
that persist even in defect-rich, solution-grown samples. Paradoxically, perovskites
are also known for having very short exciton decay times. Here, we resolve this
apparent contradiction by showing that key optoelectronic properties of perovskites
can be explained by localized flexoelectric polarization confined to interfaces
between domains of spontaneous strain. Using birefringence imaging, electrochemical
staining, and zero-bias photocurrent measurements, we visualize the domain structure
and directly probe the associated internal fields in nominally cubic single crystals
of methylammonium lead bromide. We demonstrate that localized flexoelectric fields
spatially separate electrons and holes to opposite sides of domain walls, exponentially
suppressing recombination. Domain walls thus act as efficient mesoscopic transport
channels for long-lived photocarriers, microscopically linking structural heterogeneity
to charge transport and offering mechanistically informed design principles for
perovskite solar-energy technologies.
acknowledged_ssus:
- _id: Bio
- _id: M-Shop
acknowledgement: We are grateful to A. G. Volosniev for the valuable discussions.
We thank D. Milius for the assistance with microscopy. D. R. would like to thank
F. Filakovský and T. Čuchráč for the valuable discussions. This research was supported
by the Scientific Service Units (SSU) of ISTA through resources provided by the
Imaging & Optics Facility (IOF) and the Miba Machine Shop Facility (MS).
article_number: '946'
article_processing_charge: Yes
article_type: original
author:
- first_name: Dmytro
full_name: Rak, Dmytro
id: 70313b46-47c2-11ec-9e88-cd79101918fe
last_name: Rak
- first_name: Dusan
full_name: Lorenc, Dusan
id: 40D8A3E6-F248-11E8-B48F-1D18A9856A87
last_name: Lorenc
- first_name: Daniel
full_name: Balazs, Daniel
id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E
last_name: Balazs
orcid: 0000-0001-7597-043X
- first_name: Ayan A.
full_name: Zhumekenov, Ayan A.
last_name: Zhumekenov
- first_name: Osman M.
full_name: Bakr, Osman M.
last_name: Bakr
- first_name: Zhanybek
full_name: Alpichshev, Zhanybek
id: 45E67A2A-F248-11E8-B48F-1D18A9856A87
last_name: Alpichshev
orcid: 0000-0002-7183-5203
citation:
ama: Rak D, Lorenc D, Balazs D, Zhumekenov AA, Bakr OM, Alpichshev Z. Flexoelectric
domain walls enable charge separation and transport in cubic perovskites. Nature
Communications. 2026;17. doi:10.1038/s41467-026-68660-5
apa: Rak, D., Lorenc, D., Balazs, D., Zhumekenov, A. A., Bakr, O. M., & Alpichshev,
Z. (2026). Flexoelectric domain walls enable charge separation and transport in
cubic perovskites. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-026-68660-5
chicago: Rak, Dmytro, Dusan Lorenc, Daniel Balazs, Ayan A. Zhumekenov, Osman M.
Bakr, and Zhanybek Alpichshev. “Flexoelectric Domain Walls Enable Charge Separation
and Transport in Cubic Perovskites.” Nature Communications. Springer Nature,
2026. https://doi.org/10.1038/s41467-026-68660-5.
ieee: D. Rak, D. Lorenc, D. Balazs, A. A. Zhumekenov, O. M. Bakr, and Z. Alpichshev,
“Flexoelectric domain walls enable charge separation and transport in cubic perovskites,”
Nature Communications, vol. 17. Springer Nature, 2026.
ista: Rak D, Lorenc D, Balazs D, Zhumekenov AA, Bakr OM, Alpichshev Z. 2026. Flexoelectric
domain walls enable charge separation and transport in cubic perovskites. Nature
Communications. 17, 946.
mla: Rak, Dmytro, et al. “Flexoelectric Domain Walls Enable Charge Separation and
Transport in Cubic Perovskites.” Nature Communications, vol. 17, 946, Springer
Nature, 2026, doi:10.1038/s41467-026-68660-5.
short: D. Rak, D. Lorenc, D. Balazs, A.A. Zhumekenov, O.M. Bakr, Z. Alpichshev,
Nature Communications 17 (2026).
corr_author: '1'
date_created: 2026-03-02T10:06:58Z
date_published: 2026-02-16T00:00:00Z
date_updated: 2026-04-28T12:12:46Z
day: '16'
ddc:
- '530'
department:
- _id: ZhAl
- _id: LifeSc
doi: 10.1038/s41467-026-68660-5
external_id:
pmid:
- '41698893'
file:
- access_level: open_access
checksum: dd7a98de892d0b5abefca7e290ca0f77
content_type: application/pdf
creator: dernst
date_created: 2026-03-02T14:27:56Z
date_updated: 2026-03-02T14:27:56Z
file_id: '21390'
file_name: 2026_NatureComm_Rak.pdf
file_size: 2570918
relation: main_file
success: 1
file_date_updated: 2026-03-02T14:27:56Z
has_accepted_license: '1'
intvolume: ' 17'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/explaining-next-generation-solar-cells/
scopus_import: '1'
status: public
title: Flexoelectric domain walls enable charge separation and transport in cubic
perovskites
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 17
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21845'
abstract:
- lang: eng
text: UTe2 exhibits the remarkable phenomenon of re-entrant superconductivity, whereby
the zero-resistance state reappears above 40 tesla after being suppressed with
a field of around 10 tesla. One potential pairing mechanism, invoked in the related
re-entrant superconductors UCoGe and URhGe, involves transverse fluctuations of
a ferromagnetic order parameter. However, the requisite ferromagnetic order—present
in both UCoGe and URhGe—is absent in UTe2, and neutron scattering shows instead
that the magnetic susceptibility is peaked at an antiferromagnetic wavevector.
Here, we measure the magnetotropic susceptibility of UTe2 across two field-angle
planes. This quantity is sensitive to the magnetic susceptibility in a direction
transverse to the applied magnetic field—a quantity that is not accessed in conventional
magnetization measurements. We observe a very large decrease in the magnetotropic
susceptibility over a broad range of field orientations, indicating a large increase
in the transverse magnetic susceptibility. Because our technique probes the magnetic
susceptibility in the long wavelength (q = 0) limit, this suggests that the strong
transverse susceptibility arises from ferromagnetic spin fluctuations. These ferromagnetic
fluctuations are likely important for understanding the pairing mechanism in UTe2,
as all three superconducting phases of UTe2 surround this region of enhanced susceptibility
in the field-angle phase diagram.
acknowledged_ssus:
- _id: NanoFab
acknowledgement: We appreciate technical support from Salvatore Bagiante, Evgeniia
Volobueva, Lubuna Shafeek, Ali Bangura, and Zoltán Köllö, and scientific discussions
with Daniel Agterberg, Johnpierre Paglione, Qimiao Si, Josephine Yu and Yue Yu.
V.Z., A.N., M.N., and K.A.M. acknowledge funding received from the European Research
Council (ERC) under the European Union’s Horizon 2020 research and innovation programme
(TROPIC-101078696). V.Z., A.N., M.N., and K.A.M. thank the ISTA Nanofabrication
Facility for technical support. B.J.R. acknowledges funding from the Office of Basic
Energy Sciences of the United States Department of Energy under award number DE-SC0020143
for data analysis and writing. The National High Magnetic Field Laboratory is supported
by the National Science Foundation through NSF/DMR-2128556*, the State of Florida,
and the U.S. Department of Energy. A.S. acknowledges support from the DOE/BES “Science
of 100 T” grant. A.S. thanks Downtown Subscription in Santa Fe, NM, for their patience
in hosting him. Sample preparation and characterization were supported by the NSF
through DMR-2105191.
article_number: '3742'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Valeska
full_name: Zambra, Valeska
id: 467ed36b-dc96-11ea-b7c8-b043a380b282
last_name: Zambra
orcid: 0000-0002-8806-5719
- first_name: Amit
full_name: Nathwani, Amit
id: 1a362536-4d02-11f1-8543-8351136efc50
last_name: Nathwani
- first_name: Muhammad
full_name: Nauman, Muhammad
id: 32c21954-2022-11eb-9d5f-af9f93c24e71
last_name: Nauman
orcid: 0000-0002-2111-4846
- first_name: Sylvia K.
full_name: Lewin, Sylvia K.
last_name: Lewin
- first_name: Corey E.
full_name: Frank, Corey E.
last_name: Frank
- first_name: Nicholas P.
full_name: Butch, Nicholas P.
last_name: Butch
- first_name: Arkady
full_name: Shekhter, Arkady
last_name: Shekhter
- first_name: B. J.
full_name: Ramshaw, B. J.
last_name: Ramshaw
- first_name: Kimberly A
full_name: Modic, Kimberly A
id: 13C26AC0-EB69-11E9-87C6-5F3BE6697425
last_name: Modic
orcid: 0000-0001-9760-3147
citation:
ama: Zambra V, Nathwani A, Nauman M, et al. Giant transverse magnetic fluctuations
at the edge of re-entrant superconductivity in UTe2. Nature Communications.
2026;17. doi:10.1038/s41467-026-71899-7
apa: Zambra, V., Nathwani, A., Nauman, M., Lewin, S. K., Frank, C. E., Butch, N.
P., … Modic, K. A. (2026). Giant transverse magnetic fluctuations at the edge
of re-entrant superconductivity in UTe2. Nature Communications. Springer
Nature. https://doi.org/10.1038/s41467-026-71899-7
chicago: Zambra, Valeska, Amit Nathwani, Muhammad Nauman, Sylvia K. Lewin, Corey
E. Frank, Nicholas P. Butch, Arkady Shekhter, B. J. Ramshaw, and Kimberly A Modic.
“Giant Transverse Magnetic Fluctuations at the Edge of Re-Entrant Superconductivity
in UTe2.” Nature Communications. Springer Nature, 2026. https://doi.org/10.1038/s41467-026-71899-7.
ieee: V. Zambra et al., “Giant transverse magnetic fluctuations at the edge
of re-entrant superconductivity in UTe2,” Nature Communications, vol. 17.
Springer Nature, 2026.
ista: Zambra V, Nathwani A, Nauman M, Lewin SK, Frank CE, Butch NP, Shekhter A,
Ramshaw BJ, Modic KA. 2026. Giant transverse magnetic fluctuations at the edge
of re-entrant superconductivity in UTe2. Nature Communications. 17, 3742.
mla: Zambra, Valeska, et al. “Giant Transverse Magnetic Fluctuations at the Edge
of Re-Entrant Superconductivity in UTe2.” Nature Communications, vol. 17,
3742, Springer Nature, 2026, doi:10.1038/s41467-026-71899-7.
short: V. Zambra, A. Nathwani, M. Nauman, S.K. Lewin, C.E. Frank, N.P. Butch, A.
Shekhter, B.J. Ramshaw, K.A. Modic, Nature Communications 17 (2026).
corr_author: '1'
date_created: 2026-05-10T22:02:15Z
date_published: 2026-04-29T00:00:00Z
date_updated: 2026-05-11T06:36:00Z
day: '29'
ddc:
- '530'
department:
- _id: KiMo
- _id: GradSch
doi: 10.1038/s41467-026-71899-7
external_id:
arxiv:
- '2506.08984'
file:
- access_level: open_access
checksum: 8cb95b033ad2a1a7a8181f6f078c05b5
content_type: application/pdf
creator: dernst
date_created: 2026-05-11T06:32:12Z
date_updated: 2026-05-11T06:32:12Z
file_id: '21850'
file_name: 2026_NatureComm_Zambra.pdf
file_size: 1784917
relation: main_file
success: 1
file_date_updated: 2026-05-11T06:32:12Z
has_accepted_license: '1'
intvolume: ' 17'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: bd968c70-d553-11ed-ba76-cde40b0aba64
grant_number: '101078696'
name: Gaining leverage with spin liquids and superconductors
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
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scopus_import: '1'
status: public
title: Giant transverse magnetic fluctuations at the edge of re-entrant superconductivity
in UTe2
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21872'
abstract:
- lang: eng
text: Magneto-optic Kerr effect (MOKE) is a powerful probe of broken time-reversal
symmetry (T), typically used to study ferromagnets. While MOKE has been observed
in some antiferromagnets (AFMs) with vanishing magnetization, it is often associated
with structures whose symmetry is lower than basic collinear, bipartite order.
In contrast, theory predicts a mechanism for MOKE intrinsic to all AFMs of A-type,
i.e. layered AFMs in which ferromagnetic layers are antiferromagnetically aligned.
Here we report the experimental confirmation of this mechanism in a bulk AFM.
We achieve this by measuring the imaginary component of MOKE as a function of
photon energy in MnBi2Te4, an A-type AFM where T is preserved in combination with
a translation, and comparing the experimental results with model calculations.
Our model suggests that observable MOKE should be expected in all collinear A-type
AFMs with out-of-plane spin order, thus enabling optical detection of AFM domains
and expanding the scope of MOKE to few-layer AFMs.
acknowledgement: We thank Christine Kuntscher for providing optical conductivity and
reflectance data published in ref. 33, and Nicola Spaldin, Joel Moore and Bevin
Huang for useful discussions. V.S. and J.O. received support from the Gordon and
Betty Moore Foundation’s EPiQS Initiative through Grant GBMF4537 awarded to J.O.
at UC Berkeley. Experimental and theoretical work at LBNL and UC Berkeley was funded
by the Quantum Materials (KC2202) program under the U.S. Department of Energy, Office
of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering
Division under Contract No. DE-AC02-05CH11231. Work at the University of Kansas
was supported by the U.S. Department of Energy, Office of Science, Basic Energy
Sciences, EPSCoR, and Materials Sciences and Engineering Division under Award No.
DE-SC0025319. Parts of device fabrication were performed in the KU Nanofabrication
Facility, which is supported by the National Institutes of Health NIGMS P30GM145499.
Work at ORNL was supported by the U. S. Department of Energy, Office of Science,
Basic Energy Sciences, Materials Sciences and Engineering Division. For the DFT
calculations we used resources provided by the Swedish National Infrastructure for
Computing (SNIC) at C3SE. We acknowledge support from the US National Science Foundation
(NSF) Grant Number 2201516 under the Accelnet program of Office of International
Science and Engineering (OISE). This publication is funded in part by a QuantEmX
grant from ICAM and the Gordon and Betty Moore Foundation through Grant GBMF9616
to S. K.
article_processing_charge: Yes
article_type: original
author:
- first_name: Veronika
full_name: Sunko, Veronika
id: 23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3
last_name: Sunko
orcid: 0000-0003-2724-3523
- first_name: Salman
full_name: Ahsanullah, Salman
last_name: Ahsanullah
- first_name: Vivek
full_name: Jain, Vivek
last_name: Jain
- first_name: Sophie
full_name: Weber, Sophie
last_name: Weber
- first_name: Sivaloganathan
full_name: Kumaran, Sivaloganathan
last_name: Kumaran
- first_name: Jiaqiang
full_name: Yan, Jiaqiang
last_name: Yan
- first_name: Joseph
full_name: Orenstein, Joseph
last_name: Orenstein
- first_name: Dmitry
full_name: Ovchinnikov, Dmitry
last_name: Ovchinnikov
citation:
ama: Sunko V, Ahsanullah S, Jain V, et al. Magneto-optical Kerr effect in an A-type
antiferromagnet. Nature Communications. 2026. doi:10.1038/s41467-026-72577-4
apa: Sunko, V., Ahsanullah, S., Jain, V., Weber, S., Kumaran, S., Yan, J., … Ovchinnikov,
D. (2026). Magneto-optical Kerr effect in an A-type antiferromagnet. Nature
Communications. Springer Nature. https://doi.org/10.1038/s41467-026-72577-4
chicago: Sunko, Veronika, Salman Ahsanullah, Vivek Jain, Sophie Weber, Sivaloganathan
Kumaran, Jiaqiang Yan, Joseph Orenstein, and Dmitry Ovchinnikov. “Magneto-Optical
Kerr Effect in an A-Type Antiferromagnet.” Nature Communications. Springer
Nature, 2026. https://doi.org/10.1038/s41467-026-72577-4.
ieee: V. Sunko et al., “Magneto-optical Kerr effect in an A-type antiferromagnet,”
Nature Communications. Springer Nature, 2026.
ista: Sunko V, Ahsanullah S, Jain V, Weber S, Kumaran S, Yan J, Orenstein J, Ovchinnikov
D. 2026. Magneto-optical Kerr effect in an A-type antiferromagnet. Nature Communications.
mla: Sunko, Veronika, et al. “Magneto-Optical Kerr Effect in an A-Type Antiferromagnet.”
Nature Communications, Springer Nature, 2026, doi:10.1038/s41467-026-72577-4.
short: V. Sunko, S. Ahsanullah, V. Jain, S. Weber, S. Kumaran, J. Yan, J. Orenstein,
D. Ovchinnikov, Nature Communications (2026).
corr_author: '1'
date_created: 2026-05-12T21:31:27Z
date_published: 2026-05-12T00:00:00Z
date_updated: 2026-05-18T08:04:38Z
day: '12'
ddc:
- '530'
department:
- _id: VeSu
doi: 10.1038/s41467-026-72577-4
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41467-026-72577-4
month: '05'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '21422'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Magneto-optical Kerr effect in an A-type antiferromagnet
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21895'
abstract:
- lang: eng
text: The mammalian brain organises knowledge about entities in the world and relationships
between them using cognitive maps. When forming a cognitive map, there is a necessary
trade-off between extending the map to make novel inferences, and storing a veridical
copy of past experience. However, the neural mechanisms that control this trade-off
remain unknown. Using a cross-scale approach that combines a pharmacological intervention
in humans with neural network modelling, we show that the neuromodulator noradrenaline
elicits a significant ‘spread of association’ across hippocampal cognitive maps.
This neural spread of association can be explained by changes in synaptic plasticity
that predict overgeneralisation in behaviour. Thus, elevated noradrenaline during
learning increases the ‘smoothing kernel’ for plasticity across the cognitive
map, allowing disparate memories to become linked and distorted.
acknowledgement: 'We would like to thank Chamith Halahakoon, Phil Cowen, Angharad
De Cates, Beata Godlewska, Riccardo De Giorgi, Katherine Smith and Edoardo Ostinelli
for enabling this study by providing medical cover. We would like to thank Douglas
F. Tomé and Everton J. Agnes for their guidance and advice with earlier versions
of the neural network model. We would like to thank Rob Froemke for helpful discussion
when preparing the experiments. We thank Leonie Glitz and Valentina Mancini for
comments on an earlier version of the manuscript. R.S.K. was supported by an EPSRC/MRC-funded
studentship (EP/L016052/1). P.P. was supported by the Cambridge Trust, Trinity Henry
Barlow Scholarship and Trinity Hall Brockhouse Scholarship. L.C. is supported by
the Foundation for Science and Technology (FCT) (Portuguese State Budget: UID/PSI/01662/2020;
Research fellowship: 2021.00415.CEECIND). W.T.C. is funded by the Wellcome Trust
[225924/Z/22/Z]. H.C.B. is supported by a UKRI Future Leaders Fellowship (MR/W008939/1)
and the Wellcome Institutional Strategic Support Fund. H.C.B. and J.X.O. are supported
by the Medical Research Council (MR/W01971X/1). The study was supported by the NIHR
Oxford Health Biomedical Research Centre (NIHR203316). The views expressed are those
of the author(s) and not necessarily those of the NIHR or the Department of Health
and Social Care. The Wellcome Centre for Integrative Neuroimaging is supported by
core funding from the Wellcome Trust (203139/Z/16/Z and 203139/A/16/Z). This research
was funded in part by the Wellcome Trust. For the purpose of open access, the author(s)
have applied a CC BY public copyright license to any Author Accepted Manuscript
version arising from this submission.'
article_number: '3961'
article_processing_charge: Yes
article_type: original
author:
- first_name: Renée S.
full_name: Koolschijn, Renée S.
last_name: Koolschijn
- first_name: Prakriti
full_name: Parthasarathy, Prakriti
last_name: Parthasarathy
- first_name: Michael
full_name: Browning, Michael
last_name: Browning
- first_name: Xenia
full_name: Przygodda, Xenia
last_name: Przygodda
- first_name: Liliana P.
full_name: Capitão, Liliana P.
last_name: Capitão
- first_name: William T.
full_name: Clarke, William T.
last_name: Clarke
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
- first_name: Jill X.
full_name: O’Reilly, Jill X.
last_name: O’Reilly
- first_name: Helen C.
full_name: Barron, Helen C.
last_name: Barron
citation:
ama: Koolschijn RS, Parthasarathy P, Browning M, et al. Noradrenaline causes a spread
of association in the hippocampal cognitive map. Nature Communications.
2026;17. doi:10.1038/s41467-026-70659-x
apa: Koolschijn, R. S., Parthasarathy, P., Browning, M., Przygodda, X., Capitão,
L. P., Clarke, W. T., … Barron, H. C. (2026). Noradrenaline causes a spread of
association in the hippocampal cognitive map. Nature Communications. Springer
Nature. https://doi.org/10.1038/s41467-026-70659-x
chicago: Koolschijn, Renée S., Prakriti Parthasarathy, Michael Browning, Xenia Przygodda,
Liliana P. Capitão, William T. Clarke, Tim P Vogels, Jill X. O’Reilly, and Helen
C. Barron. “Noradrenaline Causes a Spread of Association in the Hippocampal Cognitive
Map.” Nature Communications. Springer Nature, 2026. https://doi.org/10.1038/s41467-026-70659-x.
ieee: R. S. Koolschijn et al., “Noradrenaline causes a spread of association
in the hippocampal cognitive map,” Nature Communications, vol. 17. Springer
Nature, 2026.
ista: Koolschijn RS, Parthasarathy P, Browning M, Przygodda X, Capitão LP, Clarke
WT, Vogels TP, O’Reilly JX, Barron HC. 2026. Noradrenaline causes a spread of
association in the hippocampal cognitive map. Nature Communications. 17, 3961.
mla: Koolschijn, Renée S., et al. “Noradrenaline Causes a Spread of Association
in the Hippocampal Cognitive Map.” Nature Communications, vol. 17, 3961,
Springer Nature, 2026, doi:10.1038/s41467-026-70659-x.
short: R.S. Koolschijn, P. Parthasarathy, M. Browning, X. Przygodda, L.P. Capitão,
W.T. Clarke, T.P. Vogels, J.X. O’Reilly, H.C. Barron, Nature Communications 17
(2026).
date_created: 2026-05-20T14:30:37Z
date_published: 2026-05-01T00:00:00Z
date_updated: 2026-05-21T07:05:01Z
day: '01'
ddc:
- '570'
department:
- _id: TiVo
doi: 10.1038/s41467-026-70659-x
external_id:
pmid:
- '41832186'
file:
- access_level: open_access
checksum: 1b529e06b1c5d6e085d60743317fd4f9
content_type: application/pdf
creator: dernst
date_created: 2026-05-21T07:01:35Z
date_updated: 2026-05-21T07:01:35Z
file_id: '21905'
file_name: 2026_NatureComm_Koolschijn.pdf
file_size: 2059139
relation: main_file
success: 1
file_date_updated: 2026-05-21T07:01:35Z
has_accepted_license: '1'
intvolume: ' 17'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Noradrenaline causes a spread of association in the hippocampal cognitive map
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '20002'
abstract:
- lang: eng
text: While the most widely used CRISPR-Cas enzyme is the Cas9 endonuclease from
Streptococcus pyogenes (Cas9), it exhibits single-turnover enzyme kinetics which
leads to long residence times on product DNA. This blocks access to DNA repair
machinery and acts as a major bottleneck during CRISPR-Cas9 gene editing. Cas9
can eventually be removed from the product by extrinsic factors, such as translocating
polymerases, but the mechanisms contributing to Cas9 dissociation following cleavage
remain poorly understood. Here, we employ truncated guide RNAs as a strategy to
weaken PAM-distal nucleic acid interactions and promote faster enzyme turnover.
Using kinetics-guided cryo-EM, we examine the conformational landscape of a multi-turnover
Cas9, including the first detailed snapshots of Cas9 dissociating from product
DNA. We discovered that while the PAM-distal product dissociates from Cas9 following
cleavage, tight binding of the PAM-proximal product directly inhibits re-binding
of new targets. Our work provides direct evidence as to why Cas9 acts as a single-turnover
enzyme and will guide future Cas9 engineering efforts.
acknowledgement: We thank Dr. Kenneth Johnson for assistance with kinetic analysis
and helpful discussion as well as Dr. Jack Bravo and members of the Taylor lab for
insightful comments on the manuscript. Data were collected at the Sauer Structural
Biology Laboratory at the University of Texas at Austin. This work was supported
by a National Institutes of Health grant R35GM138348 (to D.W.T.). The content is
solely the responsibility of the authors and does not necessarily represent the
official views of the National Institutes of Health. Computational resources for
this work were supported by the Welch Foundation grant F-1938 (to D.W.T.).
article_number: '5681'
article_processing_charge: Yes
article_type: original
author:
- first_name: Kaitlyn
full_name: Kiernan, Kaitlyn
id: 91e8ab53-b70a-11ef-adcb-f779f833b451
last_name: Kiernan
- first_name: David W.
full_name: Taylor, David W.
last_name: Taylor
citation:
ama: Kiernan K, Taylor DW. Visualization of a multi-turnover Cas9 after product
release. Nature Communications. 2025;16. doi:10.1038/s41467-025-60668-7
apa: Kiernan, K., & Taylor, D. W. (2025). Visualization of a multi-turnover
Cas9 after product release. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-025-60668-7
chicago: Kiernan, Kaitlyn, and David W. Taylor. “Visualization of a Multi-Turnover
Cas9 after Product Release.” Nature Communications. Springer Nature, 2025.
https://doi.org/10.1038/s41467-025-60668-7.
ieee: K. Kiernan and D. W. Taylor, “Visualization of a multi-turnover Cas9 after
product release,” Nature Communications, vol. 16. Springer Nature, 2025.
ista: Kiernan K, Taylor DW. 2025. Visualization of a multi-turnover Cas9 after product
release. Nature Communications. 16, 5681.
mla: Kiernan, Kaitlyn, and David W. Taylor. “Visualization of a Multi-Turnover Cas9
after Product Release.” Nature Communications, vol. 16, 5681, Springer
Nature, 2025, doi:10.1038/s41467-025-60668-7.
short: K. Kiernan, D.W. Taylor, Nature Communications 16 (2025).
date_created: 2025-07-13T22:01:21Z
date_published: 2025-07-01T00:00:00Z
date_updated: 2025-07-14T08:30:06Z
day: '01'
ddc:
- '570'
department:
- _id: LeSa
doi: 10.1038/s41467-025-60668-7
external_id:
pmid:
- '40593576'
file:
- access_level: open_access
checksum: fa9a1eaa7e2e60467768cbaed307aceb
content_type: application/pdf
creator: dernst
date_created: 2025-07-14T08:28:25Z
date_updated: 2025-07-14T08:28:25Z
file_id: '20018'
file_name: 2025_NatureComm_Kiernan.pdf
file_size: 6875712
relation: main_file
success: 1
file_date_updated: 2025-07-14T08:28:25Z
has_accepted_license: '1'
intvolume: ' 16'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Visualization of a multi-turnover Cas9 after product release
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '20183'
abstract:
- lang: eng
text: The unequal segregation of organelles has been proposed to be an intrinsic
mechanism that contributes to cell fate divergence during asymmetric cell division;
however, in vivo evidence is sparse. Using super-resolution microscopy, we analysed
the segregation of organelles during the division of the neuroblast QL.p in C.
elegans larvae. QL.p divides to generate a daughter that survives, QL.pa, and
a daughter that dies, QL.pp. We found that mitochondria segregate unequally by
density and morphology and that this is dependent on mitochondrial dynamics. Furthermore,
we found that mitochondrial density in QL.pp correlates with the time it takes
QL.pp to die. We propose that low mitochondrial density in QL.pp promotes the
cell death fate and ensures that QL.pp dies in a highly reproducible and timely
manner. Our results provide in vivo evidence that the unequal segregation of mitochondria
can contribute to cell fate divergence during asymmetric cell division in a developing
animal.
acknowledgement: We thank members of the Conradt lab, the Center for Cell and Molecular
Dynamics (https://www.uclccmd.co.uk/) and T. Schedl for discussions and comments
on the manuscript. We thank L. McGuinness for excellent technical support. Some
strains were provided by the Caenorhabditis Genetics Center (CGC), which is funded
by NIH Office of Research Infrastructure Programs (P40 OD010440). We thank Alex
Hajnal (University of Zurich, Switzerland) and Andrew deMello (ETH Zurich, Switzerland)
for their support of S.B. This work was supported by a predoctoral fellowship from
the Studienstiftung des deutschen Volkes to NM, funds from UCL (Division of Biosciences,
UCL LSM Capital Equipment Fund) to B.C., and a Wolfson Fellowship from the Royal
Society (https://royalsociety.org/) to B.C. (RSWF\R1\180008), and the Biotechnology
and Biological Sciences Research Council (https://bbsrc.ukri.org/) (BB/V007572/1
and BB/V015648/1to B.C.).
article_number: '7174'
article_processing_charge: Yes
article_type: original
author:
- first_name: Ioannis
full_name: Segos, Ioannis
last_name: Segos
- first_name: Jens
full_name: Van Eeckhoven, Jens
last_name: Van Eeckhoven
- first_name: Simon
full_name: Berger, Simon
last_name: Berger
- first_name: Nikhil
full_name: Mishra, Nikhil
id: C4D70E82-1081-11EA-B3ED-9A4C3DDC885E
last_name: Mishra
orcid: 0000-0002-6425-5788
- first_name: Eric J.
full_name: Lambie, Eric J.
last_name: Lambie
- first_name: Barbara
full_name: Conradt, Barbara
last_name: Conradt
citation:
ama: Segos I, Van Eeckhoven J, Berger S, Mishra N, Lambie EJ, Conradt B. Unequal
segregation of mitochondria during asymmetric cell division contributes to cell
fate divergence in sister cells in vivo. Nature Communications. 2025;16.
doi:10.1038/s41467-025-62484-5
apa: Segos, I., Van Eeckhoven, J., Berger, S., Mishra, N., Lambie, E. J., &
Conradt, B. (2025). Unequal segregation of mitochondria during asymmetric cell
division contributes to cell fate divergence in sister cells in vivo. Nature
Communications. Springer Nature. https://doi.org/10.1038/s41467-025-62484-5
chicago: Segos, Ioannis, Jens Van Eeckhoven, Simon Berger, Nikhil Mishra, Eric J.
Lambie, and Barbara Conradt. “Unequal Segregation of Mitochondria during Asymmetric
Cell Division Contributes to Cell Fate Divergence in Sister Cells in Vivo.” Nature
Communications. Springer Nature, 2025. https://doi.org/10.1038/s41467-025-62484-5.
ieee: I. Segos, J. Van Eeckhoven, S. Berger, N. Mishra, E. J. Lambie, and B. Conradt,
“Unequal segregation of mitochondria during asymmetric cell division contributes
to cell fate divergence in sister cells in vivo,” Nature Communications,
vol. 16. Springer Nature, 2025.
ista: Segos I, Van Eeckhoven J, Berger S, Mishra N, Lambie EJ, Conradt B. 2025.
Unequal segregation of mitochondria during asymmetric cell division contributes
to cell fate divergence in sister cells in vivo. Nature Communications. 16, 7174.
mla: Segos, Ioannis, et al. “Unequal Segregation of Mitochondria during Asymmetric
Cell Division Contributes to Cell Fate Divergence in Sister Cells in Vivo.” Nature
Communications, vol. 16, 7174, Springer Nature, 2025, doi:10.1038/s41467-025-62484-5.
short: I. Segos, J. Van Eeckhoven, S. Berger, N. Mishra, E.J. Lambie, B. Conradt,
Nature Communications 16 (2025).
date_created: 2025-08-17T22:01:35Z
date_published: 2025-08-04T00:00:00Z
date_updated: 2025-09-01T09:47:29Z
day: '04'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.1038/s41467-025-62484-5
external_id:
pmid:
- '40759648'
file:
- access_level: open_access
checksum: f28e73963ea1f55876d0d1afca0f706a
content_type: application/pdf
creator: dernst
date_created: 2025-09-01T09:46:44Z
date_updated: 2025-09-01T09:46:44Z
file_id: '20261'
file_name: 2025_NatureComm_Segos.pdf
file_size: 3775190
relation: main_file
success: 1
file_date_updated: 2025-09-01T09:46:44Z
has_accepted_license: '1'
intvolume: ' 16'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Unequal segregation of mitochondria during asymmetric cell division contributes
to cell fate divergence in sister cells in vivo
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '20452'
abstract:
- lang: eng
text: Accurate modeling of long-range forces is critical in atomistic simulations,
as they play a central role in determining the properties of material and chemical
systems. However, standard machine learning interatomic potentials (MLIPs) often
rely on short-range approximations, limiting their applicability to systems with
significant electrostatics and dispersion forces. We recently introduced the Latent
Ewald Summation (LES) method, which captures long-range electrostatics without
explicitly learning atomic charges or charge equilibration. We benchmark LES on
diverse and challenging systems, including charged molecules, ionic liquids, electrolyte
solutions, polar dipeptides, surface adsorption, electrolyte/solid interfaces,
and solid-solid interfaces. Here we show that LES can reproduce the exact atomic
charges for classical systems with fixed charges and can infer dipole and quadrupole
moments, as well as the dipole derivative with respect to atomic positions, for
quantum mechanical systems. Moreover, LES can achieve better accuracy in energy
and force predictions compared to methods that explicitly learn from charges.
acknowledgement: We thank Chunyi Zhang for providing the TiO2(101)/NaCl+NaOH+HCl(aq)
dataset and for useful discussions. We thank Jia-Xin Zhu for providing the Pt(111)/KF(aq)
dataset. We thank Tsz Wai Ko and Jonas Finkler for useful discussions and for the
DFT-optimized Au2-MgO(001) structures. We thank Junmin Chen for discussions. D.K
and B.C. acknowledge funding from Toyota Research Institute Synthesis Advanced Research
Challenge. D.S.K. and P.Z. acknowledge funding from BIDMaP Postdoctoral Fellowship.
article_number: '8763'
article_processing_charge: Yes
article_type: original
author:
- first_name: Daniel S.
full_name: King, Daniel S.
last_name: King
- first_name: Dongjin
full_name: Kim, Dongjin
last_name: Kim
- first_name: Peichen
full_name: Zhong, Peichen
last_name: Zhong
- first_name: Bingqing
full_name: Cheng, Bingqing
id: cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9
last_name: Cheng
orcid: 0000-0002-3584-9632
citation:
ama: King DS, Kim D, Zhong P, Cheng B. Machine learning of charges and long-range
interactions from energies and forces. Nature Communications. 2025;16.
doi:10.1038/s41467-025-63852-x
apa: King, D. S., Kim, D., Zhong, P., & Cheng, B. (2025). Machine learning of
charges and long-range interactions from energies and forces. Nature Communications.
Springer Nature. https://doi.org/10.1038/s41467-025-63852-x
chicago: King, Daniel S., Dongjin Kim, Peichen Zhong, and Bingqing Cheng. “Machine
Learning of Charges and Long-Range Interactions from Energies and Forces.” Nature
Communications. Springer Nature, 2025. https://doi.org/10.1038/s41467-025-63852-x.
ieee: D. S. King, D. Kim, P. Zhong, and B. Cheng, “Machine learning of charges and
long-range interactions from energies and forces,” Nature Communications,
vol. 16. Springer Nature, 2025.
ista: King DS, Kim D, Zhong P, Cheng B. 2025. Machine learning of charges and long-range
interactions from energies and forces. Nature Communications. 16, 8763.
mla: King, Daniel S., et al. “Machine Learning of Charges and Long-Range Interactions
from Energies and Forces.” Nature Communications, vol. 16, 8763, Springer
Nature, 2025, doi:10.1038/s41467-025-63852-x.
short: D.S. King, D. Kim, P. Zhong, B. Cheng, Nature Communications 16 (2025).
corr_author: '1'
date_created: 2025-10-12T22:01:25Z
date_published: 2025-10-01T00:00:00Z
date_updated: 2026-02-16T12:21:50Z
day: '01'
ddc:
- '000'
department:
- _id: BiCh
doi: 10.1038/s41467-025-63852-x
external_id:
isi:
- '001586620700015'
pmid:
- '41034200'
file:
- access_level: open_access
checksum: 34b6005d349bbff85839c4e51d6c8725
content_type: application/pdf
creator: dernst
date_created: 2025-10-13T07:54:51Z
date_updated: 2025-10-13T07:54:51Z
file_id: '20460'
file_name: 2025_NatureComm_King.pdf
file_size: 4907055
relation: main_file
success: 1
file_date_updated: 2025-10-13T07:54:51Z
has_accepted_license: '1'
intvolume: ' 16'
isi: 1
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Machine learning of charges and long-range interactions from energies and forces
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '20728'
abstract:
- lang: eng
text: Glaciers are often located in steep mountain settings and avalanches from
surrounding slopes can strongly influence snow accumulation patterns on their
surface. This effect has however never been quantified for more than a few glaciers
and the impact on the future evolution of glaciers is unclear. We coupled an avalanche
and a glacier model to estimate the contribution of avalanches to the accumulation
of all glaciers in the world and how this affects their evolution throughout the
21st century. Globally, 3% of the snow accumulation on glaciers comes from avalanches
and 1% is removed by avalanches. This net contribution varies between regions
and glaciers, with a maximum of 15% for New Zealand. Accounting for avalanches
modifies the altitudinal pattern of glacier mass balance and the projected evolution
of individual glaciers. The main effects include (1) a longer persistence of small
glaciers, with for example three times more ice retained by glaciers smaller than
1 km2 in Central Europe under a low-emission scenario, and (2) an increased sensitivity
of high-elevation accumulation zones to future warming. We anticipate the relative
influence of avalanches to increase in the future and advocate for a better monitoring
of this process and representation in glacier models.
acknowledgement: This project has received funding from the Swiss National Science
Foundation (SNSF) under the Postdoc. Mobility programme, grant agreement P500PN_210739,
CAIRN (MK), “Contribution of avalanches to glacier mass balance”, and grant agreement
P5R5PN_225605, CAIRN-GLOBAL (MK), “Contribution of avalanches to glacier mass balance
at the global scale”. The authors would like to acknowledge the OGGM community for
the extensive online documentation, data resources (OGGM-shop) and computing infrastructure
that were used as part of this study.
article_number: '10122'
article_processing_charge: Yes
article_type: original
author:
- first_name: Marin
full_name: Kneib, Marin
last_name: Kneib
- first_name: Fabien
full_name: Maussion, Fabien
last_name: Maussion
- first_name: Fanny
full_name: Brun, Fanny
last_name: Brun
- first_name: Guillem
full_name: Carcanade, Guillem
last_name: Carcanade
- first_name: Daniel
full_name: Farinotti, Daniel
last_name: Farinotti
- first_name: Matthias
full_name: Huss, Matthias
last_name: Huss
- first_name: Marit
full_name: Van Tiel, Marit
last_name: Van Tiel
- first_name: Achille
full_name: Jouberton, Achille
id: f2426a39-920b-11f0-ac40-cbeda2086b9c
last_name: Jouberton
- first_name: Patrick
full_name: Schmitt, Patrick
last_name: Schmitt
- first_name: Lilian
full_name: Schuster, Lilian
last_name: Schuster
- first_name: Amaury
full_name: Dehecq, Amaury
last_name: Dehecq
- first_name: Nicolas
full_name: Champollion, Nicolas
last_name: Champollion
citation:
ama: Kneib M, Maussion F, Brun F, et al. Topographically-controlled contribution
of avalanches to glacier mass balance in the 21st century. Nature Communications.
2025;16. doi:10.1038/s41467-025-65608-z
apa: Kneib, M., Maussion, F., Brun, F., Carcanade, G., Farinotti, D., Huss, M.,
… Champollion, N. (2025). Topographically-controlled contribution of avalanches
to glacier mass balance in the 21st century. Nature Communications. Springer
Nature. https://doi.org/10.1038/s41467-025-65608-z
chicago: Kneib, Marin, Fabien Maussion, Fanny Brun, Guillem Carcanade, Daniel Farinotti,
Matthias Huss, Marit Van Tiel, et al. “Topographically-Controlled Contribution
of Avalanches to Glacier Mass Balance in the 21st Century.” Nature Communications.
Springer Nature, 2025. https://doi.org/10.1038/s41467-025-65608-z.
ieee: M. Kneib et al., “Topographically-controlled contribution of avalanches
to glacier mass balance in the 21st century,” Nature Communications, vol.
16. Springer Nature, 2025.
ista: Kneib M, Maussion F, Brun F, Carcanade G, Farinotti D, Huss M, Van Tiel M,
Jouberton A, Schmitt P, Schuster L, Dehecq A, Champollion N. 2025. Topographically-controlled
contribution of avalanches to glacier mass balance in the 21st century. Nature
Communications. 16, 10122.
mla: Kneib, Marin, et al. “Topographically-Controlled Contribution of Avalanches
to Glacier Mass Balance in the 21st Century.” Nature Communications, vol.
16, 10122, Springer Nature, 2025, doi:10.1038/s41467-025-65608-z.
short: M. Kneib, F. Maussion, F. Brun, G. Carcanade, D. Farinotti, M. Huss, M. Van
Tiel, A. Jouberton, P. Schmitt, L. Schuster, A. Dehecq, N. Champollion, Nature
Communications 16 (2025).
date_created: 2025-12-07T23:02:00Z
date_published: 2025-12-01T00:00:00Z
date_updated: 2025-12-09T12:38:44Z
day: '01'
ddc:
- '550'
department:
- _id: FrPe
doi: 10.1038/s41467-025-65608-z
external_id:
pmid:
- '41298449'
file:
- access_level: open_access
checksum: 5d8e420caa8259b67801f7c87e318d2e
content_type: application/pdf
creator: dernst
date_created: 2025-12-09T12:37:14Z
date_updated: 2025-12-09T12:37:14Z
file_id: '20740'
file_name: 2025_NatureComm_Kneib.pdf
file_size: 2749558
relation: main_file
success: 1
file_date_updated: 2025-12-09T12:37:14Z
has_accepted_license: '1'
intvolume: ' 16'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Topographically-controlled contribution of avalanches to glacier mass balance
in the 21st century
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '20796'
abstract:
- lang: eng
text: Rapid prophase chromosome movements ensure faithful alignment of the parental
homologous chromosomes and successful synapsis formation during meiosis. These
movements are driven by cytoplasmic forces transmitted to the nuclear periphery,
where chromosome ends are attached through transmembrane proteins. During many
developmental stages a specific genome architecture with chromatin nuclear periphery
contacts mediates specific gene expression. Whether chromatin is removed from
the nuclear periphery as a consequence of chromosome motions or by a specific
mechanism is not fully understood. Here, we identify a mechanism to remove chromatin
from the nuclear periphery through vaccinia related kinase (VRK-1)–dependent phosphorylation
of Barrier to Autointegration Factor 1 (BAF-1) in Caenorhabditis elegans early
prophase of meiosis. Interfering with chromatin removal delays chromosome pairing,
impairs synapsis, produces oocytes with abnormal chromosomes and elevated apoptosis.
Long read sequencing reveals deletions and duplications in offspring lacking VRK-1
underscoring the importance of the BAF-1–VRK-1 module in preserving genome stability
in gametes during rapid chromosome movements.
acknowledgement: We are grateful to Monique Zetka, Nicola Silva, and Yumi Kim, Needhi
Bhalla, George Krohne and Rueyling Lin for providing reagents; Scott Kennedy for
sharing the multiplexed FISH library; and members of the Max Perutz Labs’ BioOptics
facility (Irmgard Fischer, Josef Gotzmann, Thomas Peterbauer, Clara Bodner, and
Nick Wedige) for training and support in image acquisition. We also thank the members
of the NGS facility at the Vienna Biocenter. This work was funded by the Austrian
Science Fund (FWF) SFB projects F 8805-B (VJ), https://doi.org/10.55776/F88, F 8809-B
(ITB), and F8810-B (BV). We are also grateful to members of the V. Jantsch laboratory
for helpful discussions. Some strains were provided by the Caenorhabditis Genetics
Center, which is funded by the National Institutes of Health Office of Research
Infrastructure Programs (P40OD010440).
article_number: '10446'
article_processing_charge: Yes
article_type: original
author:
- first_name: Dimitra
full_name: Paouneskou, Dimitra
last_name: Paouneskou
- first_name: Antoine
full_name: Baudrimont, Antoine
last_name: Baudrimont
- first_name: Réka K
full_name: Kelemen, Réka K
id: 48D3F8DE-F248-11E8-B48F-1D18A9856A87
last_name: Kelemen
orcid: 0000-0002-8489-9281
- first_name: Marwan N
full_name: Elkrewi, Marwan N
id: 0B46FACA-A8E1-11E9-9BD3-79D1E5697425
last_name: Elkrewi
orcid: 0000-0002-5328-7231
- first_name: Angela
full_name: Graf, Angela
last_name: Graf
- first_name: Shehab
full_name: Moukbel Ali Aldawla, Shehab
last_name: Moukbel Ali Aldawla
- first_name: Claudia
full_name: Kölbl, Claudia
last_name: Kölbl
- first_name: Irene
full_name: Tiemann-Boege, Irene
last_name: Tiemann-Boege
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
- first_name: Verena
full_name: Jantsch, Verena
last_name: Jantsch
citation:
ama: Paouneskou D, Baudrimont A, Kelemen RK, et al. BAF-1–VRK-1 mediated release
of meiotic chromosomes from the nuclear periphery is important for genome integrity.
Nature Communications. 2025;16. doi:10.1038/s41467-025-65420-9
apa: Paouneskou, D., Baudrimont, A., Kelemen, R. K., Elkrewi, M. N., Graf, A., Moukbel
Ali Aldawla, S., … Jantsch, V. (2025). BAF-1–VRK-1 mediated release of meiotic
chromosomes from the nuclear periphery is important for genome integrity. Nature
Communications. Springer Nature. https://doi.org/10.1038/s41467-025-65420-9
chicago: Paouneskou, Dimitra, Antoine Baudrimont, Réka K Kelemen, Marwan N Elkrewi,
Angela Graf, Shehab Moukbel Ali Aldawla, Claudia Kölbl, Irene Tiemann-Boege, Beatriz
Vicoso, and Verena Jantsch. “BAF-1–VRK-1 Mediated Release of Meiotic Chromosomes
from the Nuclear Periphery Is Important for Genome Integrity.” Nature Communications.
Springer Nature, 2025. https://doi.org/10.1038/s41467-025-65420-9.
ieee: D. Paouneskou et al., “BAF-1–VRK-1 mediated release of meiotic chromosomes
from the nuclear periphery is important for genome integrity,” Nature Communications,
vol. 16. Springer Nature, 2025.
ista: Paouneskou D, Baudrimont A, Kelemen RK, Elkrewi MN, Graf A, Moukbel Ali Aldawla
S, Kölbl C, Tiemann-Boege I, Vicoso B, Jantsch V. 2025. BAF-1–VRK-1 mediated release
of meiotic chromosomes from the nuclear periphery is important for genome integrity.
Nature Communications. 16, 10446.
mla: Paouneskou, Dimitra, et al. “BAF-1–VRK-1 Mediated Release of Meiotic Chromosomes
from the Nuclear Periphery Is Important for Genome Integrity.” Nature Communications,
vol. 16, 10446, Springer Nature, 2025, doi:10.1038/s41467-025-65420-9.
short: D. Paouneskou, A. Baudrimont, R.K. Kelemen, M.N. Elkrewi, A. Graf, S. Moukbel
Ali Aldawla, C. Kölbl, I. Tiemann-Boege, B. Vicoso, V. Jantsch, Nature Communications
16 (2025).
date_created: 2025-12-11T10:45:06Z
date_published: 2025-11-25T00:00:00Z
date_updated: 2025-12-15T09:28:37Z
day: '25'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1038/s41467-025-65420-9
external_id:
pmid:
- '41290579'
file:
- access_level: open_access
checksum: a952f7ea050242b79008540de49a0e61
content_type: application/pdf
creator: dernst
date_created: 2025-12-15T09:25:51Z
date_updated: 2025-12-15T09:25:51Z
file_id: '20823'
file_name: 2025_NatureComm_Paouneskou.pdf
file_size: 8096309
relation: main_file
success: 1
file_date_updated: 2025-12-15T09:25:51Z
has_accepted_license: '1'
intvolume: ' 16'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 34ae1506-11ca-11ed-8bc3-c14f4c474396
grant_number: F8810
name: The highjacking of meiosis for asexual reproduction
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: BAF-1–VRK-1 mediated release of meiotic chromosomes from the nuclear periphery
is important for genome integrity
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '18820'
abstract:
- lang: eng
text: 'Feature selection is essential in the analysis of molecular systems and many
other fields, but several uncertainties remain: What is the optimal number of
features for a simplified, interpretable model that retains essential information?
How should features with different units be aligned, and how should their relative
importance be weighted? Here, we introduce the Differentiable Information Imbalance
(DII), an automated method to rank information content between sets of features.
Using distances in a ground truth feature space, DII identifies a low-dimensional
subset of features that best preserves these relationships. Each feature is scaled
by a weight, which is optimized by minimizing the DII through gradient descent.
This allows simultaneously performing unit alignment and relative importance scaling,
while preserving interpretability. DII can also produce sparse solutions and determine
the optimal size of the reduced feature space. We demonstrate the usefulness of
this approach on two benchmark molecular problems: (1) identifying collective
variables that describe conformations of a biomolecule, and (2) selecting features
for training a machine-learning force field. These results show the potential
of DII in addressing feature selection challenges and optimizing dimensionality
in various applications. The method is available in the Python library DADApy.'
acknowledgement: The authors thank Dr. Matteo Carli for providing the CLN025 replica
exchange MD trajectory and Matteo Allione for the fruitful discussions connected
with the idea of the linear scaling estimator. This work was partially funded by
NextGenerationEU through the Italian National Centre for HPC, Big Data, and Quantum
Computing (Grant No. CN00000013 received by A.L.). A.L. also acknowledges financial
support by the region Friuli Venezia Giulia (project F53C22001770002 received by
A.L.).
article_number: '270'
article_processing_charge: Yes
article_type: original
author:
- first_name: Romina
full_name: Wild, Romina
last_name: Wild
- first_name: Felix
full_name: Wodaczek, Felix
id: 8b4b6a9f-32b0-11ee-9fa8-bbe85e26258e
last_name: Wodaczek
orcid: 0009-0000-1457-795X
- first_name: Vittorio
full_name: Del Tatto, Vittorio
last_name: Del Tatto
- first_name: Bingqing
full_name: Cheng, Bingqing
id: cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9
last_name: Cheng
orcid: 0000-0002-3584-9632
- first_name: Alessandro
full_name: Laio, Alessandro
last_name: Laio
citation:
ama: Wild R, Wodaczek F, Del Tatto V, Cheng B, Laio A. Automatic feature selection
and weighting in molecular systems using Differentiable Information Imbalance.
Nature Communications. 2025;16. doi:10.1038/s41467-024-55449-7
apa: Wild, R., Wodaczek, F., Del Tatto, V., Cheng, B., & Laio, A. (2025). Automatic
feature selection and weighting in molecular systems using Differentiable Information
Imbalance. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-024-55449-7
chicago: Wild, Romina, Felix Wodaczek, Vittorio Del Tatto, Bingqing Cheng, and Alessandro
Laio. “Automatic Feature Selection and Weighting in Molecular Systems Using Differentiable
Information Imbalance.” Nature Communications. Springer Nature, 2025. https://doi.org/10.1038/s41467-024-55449-7.
ieee: R. Wild, F. Wodaczek, V. Del Tatto, B. Cheng, and A. Laio, “Automatic feature
selection and weighting in molecular systems using Differentiable Information
Imbalance,” Nature Communications, vol. 16. Springer Nature, 2025.
ista: Wild R, Wodaczek F, Del Tatto V, Cheng B, Laio A. 2025. Automatic feature
selection and weighting in molecular systems using Differentiable Information
Imbalance. Nature Communications. 16, 270.
mla: Wild, Romina, et al. “Automatic Feature Selection and Weighting in Molecular
Systems Using Differentiable Information Imbalance.” Nature Communications,
vol. 16, 270, Springer Nature, 2025, doi:10.1038/s41467-024-55449-7.
short: R. Wild, F. Wodaczek, V. Del Tatto, B. Cheng, A. Laio, Nature Communications
16 (2025).
date_created: 2025-01-12T23:04:00Z
date_published: 2025-01-02T00:00:00Z
date_updated: 2025-02-27T12:41:25Z
day: '02'
ddc:
- '570'
department:
- _id: AnSa
- _id: BiCh
doi: 10.1038/s41467-024-55449-7
external_id:
isi:
- '001389959100009'
pmid:
- '39747013'
file:
- access_level: open_access
checksum: b3d0f3568d9a87c494cf231a5324029a
content_type: application/pdf
creator: dernst
date_created: 2025-01-14T06:59:25Z
date_updated: 2025-01-14T06:59:25Z
file_id: '18846'
file_name: 2025_NatureComm_Wild.pdf
file_size: 1216738
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file_date_updated: 2025-01-14T06:59:25Z
has_accepted_license: '1'
intvolume: ' 16'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Automatic feature selection and weighting in molecular systems using Differentiable
Information Imbalance
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '18848'
abstract:
- lang: eng
text: Type II CRISPR endonucleases are widely used programmable genome editing tools.
Recently, CRISPR-Cas systems with highly compact nucleases have been discovered,
including Cas9d (a type II-D nuclease). Here, we report the cryo-EM structures
of a Cas9d nuclease (747 amino acids in length) in multiple functional states,
revealing a stepwise process of DNA targeting involving a conformational switch
in a REC2 domain insertion. Our structures provide insights into the intricately
folded guide RNA which acts as a structural scaffold to anchor small, flexible
protein domains for DNA recognition. The sgRNA can be truncated by up to ~25%
yet still retain activity in vivo. Using ancestral sequence reconstruction, we
generated compact nucleases capable of efficient genome editing in mammalian cells.
Collectively, our results provide mechanistic insights into the evolution and
DNA targeting of diverse type II CRISPR-Cas systems, providing a blueprint for
future re-engineering of minimal RNA-guided DNA endonucleases.
acknowledgement: We would like to thank M. Ocampo Camacho and M.F. Canedo Ocampo for
assistance with the figures. We thank M. Hooper for assistance developing the GFP
assay and operating the CE machine for in vitro cleavage analysis. We thank E. Schwartz
and A. Brilot for expert cryo-EM support in the Sauer Structural Biology Laboratory
at UT Austin. This work was funded, in part, by a sponsored research agreement with
Metagenomi, Inc. (to D.W.T), a Welch Foundation Research Grant F-1938 (to D.W.T),
and the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation Medical Research
Grant (to D.W.T), and a grant from the National Institute of Allergy and Infectious
Diseases (NIAID 1R01AI110577 to K.A.J.).
article_number: '457'
article_processing_charge: Yes
article_type: original
author:
- first_name: Rodrigo Fregoso
full_name: Ocampo, Rodrigo Fregoso
last_name: Ocampo
- first_name: Jack Peter Kelly
full_name: Bravo, Jack Peter Kelly
id: 96aecfa5-8931-11ee-af30-aa6a5d6eee0e
last_name: Bravo
orcid: 0000-0003-0456-0753
- first_name: Tyler L.
full_name: Dangerfield, Tyler L.
last_name: Dangerfield
- first_name: Isabel
full_name: Nocedal, Isabel
last_name: Nocedal
- first_name: Samatar A.
full_name: Jirde, Samatar A.
last_name: Jirde
- first_name: Lisa M.
full_name: Alexander, Lisa M.
last_name: Alexander
- first_name: Nicole C.
full_name: Thomas, Nicole C.
last_name: Thomas
- first_name: Anjali
full_name: Das, Anjali
last_name: Das
- first_name: Sarah
full_name: Nielson, Sarah
last_name: Nielson
- first_name: Kenneth A.
full_name: Johnson, Kenneth A.
last_name: Johnson
- first_name: Christopher T.
full_name: Brown, Christopher T.
last_name: Brown
- first_name: Cristina N.
full_name: Butterfield, Cristina N.
last_name: Butterfield
- first_name: Daniela S.A.
full_name: Goltsman, Daniela S.A.
last_name: Goltsman
- first_name: David W.
full_name: Taylor, David W.
last_name: Taylor
citation:
ama: Ocampo RF, Bravo JPK, Dangerfield TL, et al. DNA targeting by compact Cas9d
and its resurrected ancestor. Nature Communications. 2025;16. doi:10.1038/s41467-024-55573-4
apa: Ocampo, R. F., Bravo, J. P. K., Dangerfield, T. L., Nocedal, I., Jirde, S.
A., Alexander, L. M., … Taylor, D. W. (2025). DNA targeting by compact Cas9d and
its resurrected ancestor. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-024-55573-4
chicago: Ocampo, Rodrigo Fregoso, Jack Peter Kelly Bravo, Tyler L. Dangerfield,
Isabel Nocedal, Samatar A. Jirde, Lisa M. Alexander, Nicole C. Thomas, et al.
“DNA Targeting by Compact Cas9d and Its Resurrected Ancestor.” Nature Communications.
Springer Nature, 2025. https://doi.org/10.1038/s41467-024-55573-4.
ieee: R. F. Ocampo et al., “DNA targeting by compact Cas9d and its resurrected
ancestor,” Nature Communications, vol. 16. Springer Nature, 2025.
ista: Ocampo RF, Bravo JPK, Dangerfield TL, Nocedal I, Jirde SA, Alexander LM, Thomas
NC, Das A, Nielson S, Johnson KA, Brown CT, Butterfield CN, Goltsman DSA, Taylor
DW. 2025. DNA targeting by compact Cas9d and its resurrected ancestor. Nature
Communications. 16, 457.
mla: Ocampo, Rodrigo Fregoso, et al. “DNA Targeting by Compact Cas9d and Its Resurrected
Ancestor.” Nature Communications, vol. 16, 457, Springer Nature, 2025,
doi:10.1038/s41467-024-55573-4.
short: R.F. Ocampo, J.P.K. Bravo, T.L. Dangerfield, I. Nocedal, S.A. Jirde, L.M.
Alexander, N.C. Thomas, A. Das, S. Nielson, K.A. Johnson, C.T. Brown, C.N. Butterfield,
D.S.A. Goltsman, D.W. Taylor, Nature Communications 16 (2025).
date_created: 2025-01-19T23:01:50Z
date_published: 2025-01-07T00:00:00Z
date_updated: 2025-07-03T11:58:22Z
day: '07'
ddc:
- '570'
department:
- _id: JaBr
doi: 10.1038/s41467-024-55573-4
external_id:
pmid:
- '39774105'
file:
- access_level: open_access
checksum: 885e96690620790d5c9f188a1587b4cd
content_type: application/pdf
creator: dernst
date_created: 2025-01-22T14:35:22Z
date_updated: 2025-01-22T14:35:22Z
file_id: '18869'
file_name: 2025_NatureComm_Ocampo.pdf
file_size: 5450660
relation: main_file
success: 1
file_date_updated: 2025-01-22T14:35:22Z
has_accepted_license: '1'
intvolume: ' 16'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: DNA targeting by compact Cas9d and its resurrected ancestor
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '19402'
abstract:
- lang: eng
text: Recent advances in the field of bottom-up synthetic biology have led to the
development of synthetic cells that mimic some features of real cells, such as
division, protein synthesis, or DNA replication. Larger assemblies of synthetic
cells may be used to form prototissues. However, existing prototissues are limited
by their relatively small lateral dimensions or their lack of remodeling ability.
Here, we introduce a lipid-based tissue mimetic that can be easily prepared and
functionalized, consisting of a millimeter-sized “lipid-foam” with individual
micrometer-sized compartments bound by lipid bilayers. We characterize the structural
and mechanical properties of the lipid-foam tissue mimetic, and we demonstrate
self-healing capabilities enabled by the fluidity of the lipid bilayers. Upon
inclusion of bacteria in the tissue compartments, we observe that the tissue mimetic
exhibits network-wide tension fluctuations driven by membrane tension generation
by the swimming bacteria. Active tension fluctuations facilitate the fluidization
and reorganization of the prototissue, providing a versatile platform for understanding
and mimicking biological tissues.
acknowledgement: "This research was supported in part by the National Science Foundation
under Grant No. 1844336 (J.S.), 2239567 (A.P), and MRSEC DMR-2308691 (A.G., N.P.K.)
and the National Institutes of Health under Grant No. 1R35GM147170-01 (A.P). J.S.
thanks Reinhard Lipowsky for discussions on stability of foams.\r\nOpen Access funding
enabled and organized by Projekt DEAL."
article_number: '2026'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Andre A.
full_name: Gu, Andre A.
last_name: Gu
- first_name: Mehmet C
full_name: Ucar, Mehmet C
id: 50B2A802-6007-11E9-A42B-EB23E6697425
last_name: Ucar
orcid: 0000-0003-0506-4217
- first_name: Peter
full_name: Tran, Peter
last_name: Tran
- first_name: Arthur
full_name: Prindle, Arthur
last_name: Prindle
- first_name: Neha P.
full_name: Kamat, Neha P.
last_name: Kamat
- first_name: Jan
full_name: Steinkühler, Jan
last_name: Steinkühler
citation:
ama: Gu AA, Ucar MC, Tran P, Prindle A, Kamat NP, Steinkühler J. Remodeling of lipid-foam
prototissues by network-wide tension fluctuations induced by active particles.
Nature Communications. 2025;16. doi:10.1038/s41467-025-57178-x
apa: Gu, A. A., Ucar, M. C., Tran, P., Prindle, A., Kamat, N. P., & Steinkühler,
J. (2025). Remodeling of lipid-foam prototissues by network-wide tension fluctuations
induced by active particles. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-025-57178-x
chicago: Gu, Andre A., Mehmet C Ucar, Peter Tran, Arthur Prindle, Neha P. Kamat,
and Jan Steinkühler. “Remodeling of Lipid-Foam Prototissues by Network-Wide Tension
Fluctuations Induced by Active Particles.” Nature Communications. Springer
Nature, 2025. https://doi.org/10.1038/s41467-025-57178-x.
ieee: A. A. Gu, M. C. Ucar, P. Tran, A. Prindle, N. P. Kamat, and J. Steinkühler,
“Remodeling of lipid-foam prototissues by network-wide tension fluctuations induced
by active particles,” Nature Communications, vol. 16. Springer Nature,
2025.
ista: Gu AA, Ucar MC, Tran P, Prindle A, Kamat NP, Steinkühler J. 2025. Remodeling
of lipid-foam prototissues by network-wide tension fluctuations induced by active
particles. Nature Communications. 16, 2026.
mla: Gu, Andre A., et al. “Remodeling of Lipid-Foam Prototissues by Network-Wide
Tension Fluctuations Induced by Active Particles.” Nature Communications,
vol. 16, 2026, Springer Nature, 2025, doi:10.1038/s41467-025-57178-x.
short: A.A. Gu, M.C. Ucar, P. Tran, A. Prindle, N.P. Kamat, J. Steinkühler, Nature
Communications 16 (2025).
date_created: 2025-03-16T23:01:23Z
date_published: 2025-02-27T00:00:00Z
date_updated: 2025-09-30T10:59:30Z
day: '27'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1038/s41467-025-57178-x
external_id:
isi:
- '001435269000002'
pmid:
- '40016255'
file:
- access_level: open_access
checksum: 3bbae9b470c639005815342a39e96918
content_type: application/pdf
creator: dernst
date_created: 2025-03-17T09:43:27Z
date_updated: 2025-03-17T09:43:27Z
file_id: '19411'
file_name: 2025_NatureComm_Gu.pdf
file_size: 2260791
relation: main_file
success: 1
file_date_updated: 2025-03-17T09:43:27Z
has_accepted_license: '1'
intvolume: ' 16'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Remodeling of lipid-foam prototissues by network-wide tension fluctuations
induced by active particles
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 16
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '20977'
abstract:
- lang: eng
text: Hippocampal sharp-wave ripples (SPW-Rs) are high-frequency oscillations critical
for memory consolidation. Despite extensive characterization in rodents, their
detection in humans is limited by coarse spatial sampling, interictal epileptiform
discharges (IEDs), and a lack of consensus on human ripple localization and morphology.
Here, we demonstrate that mouse and human hippocampal ripples share spatial, spectral
and temporal features, which are clearly distinct from IEDs. In recordings from
male APP/PS1 mice, SPW-Rs were distinguishable from IEDs by multiple criteria.
Hippocampal ripples recorded during NREM sleep in female and male surgical epilepsy
patients exhibited similar narrowband frequency peaks and multiple ripple cycles
in the CA1 and subiculum regions. Conversely, IEDs showed a broad spatial extent
and wide-band frequency power. We developed a semi-automated, ripple curation
toolbox (ripmap) to separate event waveforms by low-dimensional embedding to reduce
false-positive rate in selected ripple channels. Our approach improves ripple
detection and provides a firm foundation for future human memory research.
acknowledgement: We thank Karl Rössler and Sebastian Brandner for the human SEEG implantations;
Katja Kobow for providing the histopathological findings of the patients; Jay Jeschke
for help with human electrode localization; Esha Brahmbhatt and Deren Aykan for
help with animal habituation; Mursel Karadas for the rodent treadmill design; Nicholas
Paleologos, Noam Nitzan, Michael D Hadler and Samuel McKenzie for rating events
in a human ripple survey included in a previous version of the manuscript; Nicholas
Paleologos for sharing NYU iEEG data for validating UMAP parameters; Julio Esparza
for help on the topological analysis through discussions; Thomas Hainmüller, Yiyao
Zhang and Mursel Karadas for feedback on the manuscript. We would like to acknowledge
Corticale SRL (Genoa, Italy) for providing the SiNAPS probes, and NeuroNexus (Ann
Arbor, MI) for their contribution of the data acquisition system and Radiens software.
We further acknowledge both Corticale and NeuroNexus for training and support making
this research possible. This work was supported by the German Research Foundation
(DFG; Walter Benjamin Fellowship MA 10301/1-1, A.M.), NYU Langone Health Finding
a Cure for Epilepsy and Seizures (FACES, A.M.), the NOMIS Fellowship (A.N.-O.),
the National Institutes of Health (R01NS127954, K23NS104252, A.L.; MH122391, U19NS107616,
R01MH139216 G.B.,), and the NYU Department of Neurology (A.L.).
article_number: '11636'
article_processing_charge: Yes
article_type: original
author:
- first_name: Anna
full_name: Maslarova, Anna
last_name: Maslarova
- first_name: Jiyun N.
full_name: Shin, Jiyun N.
last_name: Shin
- first_name: Andrea C
full_name: Navas Olivé, Andrea C
id: 739d26c9-52e8-11ee-8d72-f14d3893b4ce
last_name: Navas Olivé
orcid: 0000-0002-9280-8597
- first_name: Mihály
full_name: Vöröslakos, Mihály
last_name: Vöröslakos
- first_name: Hajo
full_name: Hamer, Hajo
last_name: Hamer
- first_name: Arnd
full_name: Doerfler, Arnd
last_name: Doerfler
- first_name: Simon
full_name: Henin, Simon
last_name: Henin
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
- first_name: Anli
full_name: Liu, Anli
last_name: Liu
citation:
ama: Maslarova A, Shin JN, Navas Olivé AC, et al. Spatiotemporal patterns differentiate
hippocampal sharp-wave ripples from interictal epileptiform discharges in mice
and humans. Nature Communications. 2025;16. doi:10.1038/s41467-025-66562-6
apa: Maslarova, A., Shin, J. N., Navas Olivé, A. C., Vöröslakos, M., Hamer, H.,
Doerfler, A., … Liu, A. (2025). Spatiotemporal patterns differentiate hippocampal
sharp-wave ripples from interictal epileptiform discharges in mice and humans.
Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-025-66562-6
chicago: Maslarova, Anna, Jiyun N. Shin, Andrea C Navas Olivé, Mihály Vöröslakos,
Hajo Hamer, Arnd Doerfler, Simon Henin, György Buzsáki, and Anli Liu. “Spatiotemporal
Patterns Differentiate Hippocampal Sharp-Wave Ripples from Interictal Epileptiform
Discharges in Mice and Humans.” Nature Communications. Springer Nature,
2025. https://doi.org/10.1038/s41467-025-66562-6.
ieee: A. Maslarova et al., “Spatiotemporal patterns differentiate hippocampal
sharp-wave ripples from interictal epileptiform discharges in mice and humans,”
Nature Communications, vol. 16. Springer Nature, 2025.
ista: Maslarova A, Shin JN, Navas Olivé AC, Vöröslakos M, Hamer H, Doerfler A, Henin
S, Buzsáki G, Liu A. 2025. Spatiotemporal patterns differentiate hippocampal sharp-wave
ripples from interictal epileptiform discharges in mice and humans. Nature Communications.
16, 11636.
mla: Maslarova, Anna, et al. “Spatiotemporal Patterns Differentiate Hippocampal
Sharp-Wave Ripples from Interictal Epileptiform Discharges in Mice and Humans.”
Nature Communications, vol. 16, 11636, Springer Nature, 2025, doi:10.1038/s41467-025-66562-6.
short: A. Maslarova, J.N. Shin, A.C. Navas Olivé, M. Vöröslakos, H. Hamer, A. Doerfler,
S. Henin, G. Buzsáki, A. Liu, Nature Communications 16 (2025).
date_created: 2026-01-11T23:01:35Z
date_published: 2025-12-30T00:00:00Z
date_updated: 2026-01-12T09:31:56Z
day: '30'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1038/s41467-025-66562-6
external_id:
pmid:
- '39975118'
file:
- access_level: open_access
checksum: a8a1670e197484382e087be60f643945
content_type: application/pdf
creator: dernst
date_created: 2026-01-12T09:30:15Z
date_updated: 2026-01-12T09:30:15Z
file_id: '20978'
file_name: 2025_NatureComm_Maslarova.pdf
file_size: 7629997
relation: main_file
success: 1
file_date_updated: 2026-01-12T09:30:15Z
has_accepted_license: '1'
intvolume: ' 16'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 9B861AAC-BA93-11EA-9121-9846C619BF3A
name: NOMIS Fellowship Program
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Spatiotemporal patterns differentiate hippocampal sharp-wave ripples from interictal
epileptiform discharges in mice and humans
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21248'
abstract:
- lang: eng
text: Camera-type eyes in vertebrates and cephalopods are striking examples of parallel
evolution of a complex structure. While comparisons have focused on these two
groups, camera-type eyes with likely high functionality are also found in other
invertebrate phyla with simpler brains. Employing single-cell RNA sequencing,
we identify neurogenic cells in the adult eyes and brain of the marine annelid
worm Platynereis dumerilii. Distinct neural stem cells in the camera-type adult
eyes, located at the edge of the cup-shaped retina, and adjacent to the glass
body/lens, produce radial lines of cells, reminiscent of stem cells in ciliary
marginal zones of vertebrate eyes exhibiting life-long growth. Normal proliferation
in the eye depends on ambient light, a phenomenon that depends on the integrity
of the photoreceptor gene c-opsin1, which is present in emerging rhabdomeric photoreceptors,
and impacts on their differentiation. During reproductive maturation, proliferation
in the eye as well as the entire brain sharply declines, while cells upregulate
molecular characteristics of mammalian adult neural stem cell quiescence. Our
data provide insights into the development and modulation of annelid head and
brain cells, revealing similarities and differences to vertebrate eye development,
neurogenesis and brain plasticity.
acknowledgement: 'We are grateful to Andrij Belokurov, Margaryta Borysova and Netsanet
Getachew for routine worm cultures and genotyping support, Lena Stumbauer for practical
help, as well as all members of the Tessmar-Raible and Raible labs for constructive
discussions. This work was supported by, Helmholtz Society, distinguished professorship
by the Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research (K.T.-R.),
H2020 European Research Council, ERC Grant Agreement #819952 (K.T.-R.), Austrian
Science Funds (FWF), SFB F78 (F.R., K.T-R; https://doi.org/10.55776/F78), the Human
Frontier Science Program (HFSP), #RGP021/2024, https://doi.org/10.52044/HFSP.RGP0212024.pc.gr.194174
(KT-R), University of Vienna Research Platform SinCeReSt (F.R.), For open access
purposes, K.T.-R. has applied a CC BY public copyright license to any author accepted
manuscript version arising from this submission. We acknowledge support by the Open
Access publication fund of Alfred-Wegener-Institut Helmholtz-Zentrum für Polar-
und Meeresforschung. None of the funding bodies was involved in the design of the
study, the collection, analysis, and interpretation of data or in writing the manuscript.
Open Access funding enabled and organized by Projekt DEAL.'
article_number: '9861'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Nadja
full_name: Milivojev, Nadja
last_name: Milivojev
- first_name: Federico
full_name: Scaramuzza, Federico
last_name: Scaramuzza
- first_name: Pedro Ozório
full_name: Brum, Pedro Ozório
last_name: Brum
- first_name: Camila L
full_name: Velastegui Gamboa, Camila L
id: 625aea67-91c1-11f0-aad8-f71452b4174d
last_name: Velastegui Gamboa
- first_name: Gabriele
full_name: Andreatta, Gabriele
last_name: Andreatta
- first_name: Florian
full_name: Raible, Florian
last_name: Raible
- first_name: Kristin
full_name: Tessmar-Raible, Kristin
last_name: Tessmar-Raible
citation:
ama: Milivojev N, Scaramuzza F, Brum PO, et al. Light-modulated stem cells in the
camera-type eye of an annelid model for adult brain plasticity. Nature Communications.
2025;16. doi:10.1038/s41467-025-65631-0
apa: Milivojev, N., Scaramuzza, F., Brum, P. O., Velastegui Gamboa, C. L., Andreatta,
G., Raible, F., & Tessmar-Raible, K. (2025). Light-modulated stem cells in
the camera-type eye of an annelid model for adult brain plasticity. Nature
Communications. Springer Nature. https://doi.org/10.1038/s41467-025-65631-0
chicago: Milivojev, Nadja, Federico Scaramuzza, Pedro Ozório Brum, Camila L Velastegui
Gamboa, Gabriele Andreatta, Florian Raible, and Kristin Tessmar-Raible. “Light-Modulated
Stem Cells in the Camera-Type Eye of an Annelid Model for Adult Brain Plasticity.”
Nature Communications. Springer Nature, 2025. https://doi.org/10.1038/s41467-025-65631-0.
ieee: N. Milivojev et al., “Light-modulated stem cells in the camera-type
eye of an annelid model for adult brain plasticity,” Nature Communications,
vol. 16. Springer Nature, 2025.
ista: Milivojev N, Scaramuzza F, Brum PO, Velastegui Gamboa CL, Andreatta G, Raible
F, Tessmar-Raible K. 2025. Light-modulated stem cells in the camera-type eye of
an annelid model for adult brain plasticity. Nature Communications. 16, 9861.
mla: Milivojev, Nadja, et al. “Light-Modulated Stem Cells in the Camera-Type Eye
of an Annelid Model for Adult Brain Plasticity.” Nature Communications,
vol. 16, 9861, Springer Nature, 2025, doi:10.1038/s41467-025-65631-0.
short: N. Milivojev, F. Scaramuzza, P.O. Brum, C.L. Velastegui Gamboa, G. Andreatta,
F. Raible, K. Tessmar-Raible, Nature Communications 16 (2025).
date_created: 2026-02-16T15:38:11Z
date_published: 2025-12-01T00:00:00Z
date_updated: 2026-02-18T06:41:35Z
day: '01'
department:
- _id: GradSch
doi: 10.1038/s41467-025-65631-0
intvolume: ' 16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41467-025-65631-0
month: '12'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Light-modulated stem cells in the camera-type eye of an annelid model for adult
brain plasticity
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '8616'
abstract:
- lang: eng
text: The brain vasculature supplies neurons with glucose and oxygen, but little
is known about how vascular plasticity contributes to brain function. Using longitudinal
in vivo imaging, we report that a substantial proportion of blood vessels in the
adult mouse brain sporadically occlude and regress. Their regression proceeds
through sequential stages of blood-flow occlusion, endothelial cell collapse,
relocation or loss of pericytes, and retraction of glial endfeet. Regressing vessels
are found to be widespread in mouse, monkey and human brains. We further reveal
that blood vessel regression cause a reduction of neuronal activity due to a dysfunction
in mitochondrial metabolism and glutamate production. Our results elucidate the
mechanism of vessel regression and its role in neuronal function in the adult
brain.
acknowledgement: 'The project was initiated in the Jan lab at UCSF. We thank Lily
Jan and Yuh-Nung Jan’s generous support. We thank Liqun Luo’s lab for providing
MADM-7 mice and Rolf A Brekken for VEGF-antibodies. Drs. Yuanquan Song (UPenn),
Zhaozhu Hu (JHU), Ji Hu (ShanghaiTech), Yang Xiang (U. Mass), Hao Wang (Zhejiang
U.) and Ruikang Wang (U. Washington) for critical input, colleagues at Children’s
Research Institute, Departments of Neuroscience, Neurology and Neurotherapeutics,
Pediatrics from UT Southwestern, and colleagues from the Jan lab for discussion.
Dr. Bridget Samuels, Sean Morrison (UT Southwestern), and Nannan Lu (Zhejiang U.)
for critical reading. We acknowledge the assistance of the CIBR Imaging core. We
also thank UT Southwestern Live Cell Imaging Facility, a Shared Resource of the
Harold C. Simmons Cancer Center, supported in part by an NCI Cancer Center Support
Grant, P30 CA142543K. This work is supported by CIBR funds and the American Heart
Association AWRP Summer 2016 Innovative Research Grant (17IRG33410377) to W-P.G.;
National Natural Science Foundation of China (No.81370031) to Z.Z.;National Key
Research and Development Program of China (2016YFE0125400)to F.H.;National Natural
Science Foundations of China (No. 81473202) to Y.L.; National Natural Science Foundation
of China (No.31600839) and Shenzhen Science and Technology Research Program (JCYJ20170818163320865)
to B.P.; National Natural Science Foundation of China (No. 31800864) and Westlake
University start-up funds to J-M. J. NIH R01NS088627 to W.L.J.; NIH: R01 AG020670
and RF1AG054111 to H.Z.; R01 NS088555 to A.M.S., and European Research Council No.725780
to S.H.;W-P.G. was a recipient of Bugher-American Heart Association Dan Adams Thinking
Outside the Box Award.'
article_number: '5840'
article_processing_charge: Yes
article_type: original
author:
- first_name: Xiaofei
full_name: Gao, Xiaofei
last_name: Gao
- first_name: Jun-Liszt
full_name: Li, Jun-Liszt
last_name: Li
- first_name: Xingjun
full_name: Chen, Xingjun
last_name: Chen
- first_name: Bo
full_name: Ci, Bo
last_name: Ci
- first_name: Fei
full_name: Chen, Fei
last_name: Chen
- first_name: Nannan
full_name: Lu, Nannan
last_name: Lu
- first_name: Bo
full_name: Shen, Bo
last_name: Shen
- first_name: Lijun
full_name: Zheng, Lijun
last_name: Zheng
- first_name: Jie-Min
full_name: Jia, Jie-Min
last_name: Jia
- first_name: Yating
full_name: Yi, Yating
last_name: Yi
- first_name: Shiwen
full_name: Zhang, Shiwen
last_name: Zhang
- first_name: Ying-Chao
full_name: Shi, Ying-Chao
last_name: Shi
- first_name: Kaibin
full_name: Shi, Kaibin
last_name: Shi
- first_name: Nicholas E
full_name: Propson, Nicholas E
last_name: Propson
- first_name: Yubin
full_name: Huang, Yubin
last_name: Huang
- first_name: Katherine
full_name: Poinsatte, Katherine
last_name: Poinsatte
- first_name: Zhaohuan
full_name: Zhang, Zhaohuan
last_name: Zhang
- first_name: Yuanlei
full_name: Yue, Yuanlei
last_name: Yue
- first_name: Dale B
full_name: Bosco, Dale B
last_name: Bosco
- first_name: Ying-mei
full_name: Lu, Ying-mei
last_name: Lu
- first_name: Shi-bing
full_name: Yang, Shi-bing
last_name: Yang
- first_name: Ralf H.
full_name: Adams, Ralf H.
last_name: Adams
- first_name: Volkhard
full_name: Lindner, Volkhard
last_name: Lindner
- first_name: Fen
full_name: Huang, Fen
last_name: Huang
- first_name: Long-Jun
full_name: Wu, Long-Jun
last_name: Wu
- first_name: Hui
full_name: Zheng, Hui
last_name: Zheng
- first_name: Feng
full_name: Han, Feng
last_name: Han
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
- first_name: Ann M.
full_name: Stowe, Ann M.
last_name: Stowe
- first_name: Bo
full_name: Peng, Bo
last_name: Peng
- first_name: Marta
full_name: Margeta, Marta
last_name: Margeta
- first_name: Xiaoqun
full_name: Wang, Xiaoqun
last_name: Wang
- first_name: Qiang
full_name: Liu, Qiang
last_name: Liu
- first_name: Jakob
full_name: Körbelin, Jakob
last_name: Körbelin
- first_name: Martin
full_name: Trepel, Martin
last_name: Trepel
- first_name: Hui
full_name: Lu, Hui
last_name: Lu
- first_name: Bo O.
full_name: Zhou, Bo O.
last_name: Zhou
- first_name: Hu
full_name: Zhao, Hu
last_name: Zhao
- first_name: Wenzhi
full_name: Su, Wenzhi
last_name: Su
- first_name: Robert M.
full_name: Bachoo, Robert M.
last_name: Bachoo
- first_name: Woo-ping
full_name: Ge, Woo-ping
last_name: Ge
citation:
ama: Gao X, Li J-L, Chen X, et al. Reduction of neuronal activity mediated by blood-vessel
regression in the brain. Nature Communications. 2025;16. doi:10.1038/s41467-025-60308-0
apa: Gao, X., Li, J.-L., Chen, X., Ci, B., Chen, F., Lu, N., … Ge, W. (2025). Reduction
of neuronal activity mediated by blood-vessel regression in the brain. Nature
Communications. Springer Nature. https://doi.org/10.1038/s41467-025-60308-0
chicago: Gao, Xiaofei, Jun-Liszt Li, Xingjun Chen, Bo Ci, Fei Chen, Nannan Lu, Bo
Shen, et al. “Reduction of Neuronal Activity Mediated by Blood-Vessel Regression
in the Brain.” Nature Communications. Springer Nature, 2025. https://doi.org/10.1038/s41467-025-60308-0.
ieee: X. Gao et al., “Reduction of neuronal activity mediated by blood-vessel
regression in the brain,” Nature Communications, vol. 16. Springer Nature,
2025.
ista: Gao X, Li J-L, Chen X, Ci B, Chen F, Lu N, Shen B, Zheng L, Jia J-M, Yi Y,
Zhang S, Shi Y-C, Shi K, Propson NE, Huang Y, Poinsatte K, Zhang Z, Yue Y, Bosco
DB, Lu Y, Yang S, Adams RH, Lindner V, Huang F, Wu L-J, Zheng H, Han F, Hippenmeyer
S, Stowe AM, Peng B, Margeta M, Wang X, Liu Q, Körbelin J, Trepel M, Lu H, Zhou
BO, Zhao H, Su W, Bachoo RM, Ge W. 2025. Reduction of neuronal activity mediated
by blood-vessel regression in the brain. Nature Communications. 16, 5840.
mla: Gao, Xiaofei, et al. “Reduction of Neuronal Activity Mediated by Blood-Vessel
Regression in the Brain.” Nature Communications, vol. 16, 5840, Springer
Nature, 2025, doi:10.1038/s41467-025-60308-0.
short: X. Gao, J.-L. Li, X. Chen, B. Ci, F. Chen, N. Lu, B. Shen, L. Zheng, J.-M.
Jia, Y. Yi, S. Zhang, Y.-C. Shi, K. Shi, N.E. Propson, Y. Huang, K. Poinsatte,
Z. Zhang, Y. Yue, D.B. Bosco, Y. Lu, S. Yang, R.H. Adams, V. Lindner, F. Huang,
L.-J. Wu, H. Zheng, F. Han, S. Hippenmeyer, A.M. Stowe, B. Peng, M. Margeta, X.
Wang, Q. Liu, J. Körbelin, M. Trepel, H. Lu, B.O. Zhou, H. Zhao, W. Su, R.M. Bachoo,
W. Ge, Nature Communications 16 (2025).
date_created: 2020-10-06T08:58:59Z
date_published: 2025-07-01T00:00:00Z
date_updated: 2025-09-04T07:08:37Z
day: '01'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1038/s41467-025-60308-0
ec_funded: 1
external_id:
isi:
- '001523450500035'
file:
- access_level: open_access
checksum: f59748cb67232cfb210035d9aef60836
content_type: application/pdf
creator: dernst
date_created: 2025-07-07T09:52:46Z
date_updated: 2025-07-07T09:52:46Z
file_id: '19971'
file_name: 2025_NatureComm_Gao.pdf
file_size: 17018106
relation: main_file
success: 1
file_date_updated: 2025-07-07T09:52:46Z
has_accepted_license: '1'
intvolume: ' 16'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Reduction of neuronal activity mediated by blood-vessel regression in the brain
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21541'
abstract:
- lang: eng
text: Scintillators convert X-ray energy into visible light and are critical for
imaging technologies. Their widespread use relies on scalable, high-quality manufacturing
methods. Nanophotonic scintillators, featuring wavelength-scale nanostructures,
can offer improved emission properties such as higher light yield, shorter decay
times, and enhanced directionality. However, achieving scalable fabrication of
these structures remains challenging. Here, we present a scalable fabrication
method for large-area nanophotonic scintillators based on the self-assembly of
chalcogenide glass photonic crystals. This technique enables the production of
nanophotonic scintillators over wafer-scale areas, achieving a six-fold enhancement
in light yield compared to unpatterned scintillators. By studying surface nanofabrication
disorder, we show its impact on imaging performance and provide a route towards
scintillation enhancements without compromising resolution. We demonstrate the
practical applicability of our nanophotonic scintillators through X-ray imaging
of biological and inorganic specimens. Our results could enable the industrial
implementation of a new generation of nanophotonic-enhanced scintillators.
article_number: '5750'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Louis
full_name: Martin-Monier, Louis
last_name: Martin-Monier
- first_name: Simo
full_name: Pajovic, Simo
last_name: Pajovic
- first_name: Muluneh G.
full_name: Abebe, Muluneh G.
last_name: Abebe
- first_name: Joshua
full_name: Chen, Joshua
last_name: Chen
- first_name: Sachin
full_name: Vaidya, Sachin
last_name: Vaidya
- first_name: Seokhwan
full_name: Min, Seokhwan
last_name: Min
- first_name: Seou
full_name: Choi, Seou
last_name: Choi
- first_name: Steven E.
full_name: Kooi, Steven E.
last_name: Kooi
- first_name: Bjorn
full_name: Maes, Bjorn
last_name: Maes
- first_name: Juejun
full_name: Hu, Juejun
last_name: Hu
- first_name: Marin
full_name: Soljačić, Marin
last_name: Soljačić
- first_name: Charles
full_name: Roques-Carmes, Charles
id: e2e68fc9-6505-11ef-a541-eb4e72cc3e82
last_name: Roques-Carmes
citation:
ama: Martin-Monier L, Pajovic S, Abebe MG, et al. Large-scale self-assembled nanophotonic
scintillators for X-ray imaging. Nature Communications. 2025;16. doi:10.1038/s41467-025-60953-5
apa: Martin-Monier, L., Pajovic, S., Abebe, M. G., Chen, J., Vaidya, S., Min, S.,
… Roques-Carmes, C. (2025). Large-scale self-assembled nanophotonic scintillators
for X-ray imaging. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-025-60953-5
chicago: Martin-Monier, Louis, Simo Pajovic, Muluneh G. Abebe, Joshua Chen, Sachin
Vaidya, Seokhwan Min, Seou Choi, et al. “Large-Scale Self-Assembled Nanophotonic
Scintillators for X-Ray Imaging.” Nature Communications. Springer Nature,
2025. https://doi.org/10.1038/s41467-025-60953-5.
ieee: L. Martin-Monier et al., “Large-scale self-assembled nanophotonic scintillators
for X-ray imaging,” Nature Communications, vol. 16. Springer Nature, 2025.
ista: Martin-Monier L, Pajovic S, Abebe MG, Chen J, Vaidya S, Min S, Choi S, Kooi
SE, Maes B, Hu J, Soljačić M, Roques-Carmes C. 2025. Large-scale self-assembled
nanophotonic scintillators for X-ray imaging. Nature Communications. 16, 5750.
mla: Martin-Monier, Louis, et al. “Large-Scale Self-Assembled Nanophotonic Scintillators
for X-Ray Imaging.” Nature Communications, vol. 16, 5750, Springer Nature,
2025, doi:10.1038/s41467-025-60953-5.
short: L. Martin-Monier, S. Pajovic, M.G. Abebe, J. Chen, S. Vaidya, S. Min, S.
Choi, S.E. Kooi, B. Maes, J. Hu, M. Soljačić, C. Roques-Carmes, Nature Communications
16 (2025).
date_created: 2026-03-30T12:22:47Z
date_published: 2025-07-01T00:00:00Z
date_updated: 2026-04-27T07:17:31Z
day: '01'
ddc:
- '530'
doi: 10.1038/s41467-025-60953-5
extern: '1'
external_id:
arxiv:
- '2410.07141'
intvolume: ' 16'
language:
- iso: eng
main_file_link:
- url: https://doi.org/10.1038/s41467-025-60953-5
month: '07'
oa_version: Published Version
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Large-scale self-assembled nanophotonic scintillators for X-ray imaging
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21543'
abstract:
- lang: eng
text: Observing non-classical properties of light is a long-standing interest to
advance a wide range of quantum applications. Optical cavities are essential to
generate and manipulate non-classical light. However, detecting changes in cavity
properties induced by the quantum state remains a critical challenge in the optical
domain due to the weak material nonlinearity. Here, we propose a framework for
observing the dynamics of quantum states generated inside nonlinear optical cavities.
We leverage the symmetry-breaking process of a bistable system, which is highly
sensitive to the initial state, enabling detection of quantum state displacement
through an asymmetric equilibrium of a macroscopic observable. With a nonlinear
response at the single photon level, our approach directly imprints the cavity
field distribution onto the statistics of bistable cavity steady-states. We experimentally
demonstrate our approach in a degenerate optical parametric oscillator, generating
and reconstructing different quantum states. As a validation, we reconstruct the
Husimi Q function of the cavity squeezed vacuum state. In addition, we observe
the evolution of the quantum vacuum state inside the cavity as it undergoes phase-sensitive
amplification. By enabling generation and measurement of quantum states in a single
nonlinear optical cavity, our method paves a way for studying exotic dynamics
of quantum optical states in nonlinear driven-dissipative systems.
article_number: '7576'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Seou
full_name: Choi, Seou
last_name: Choi
- first_name: Yannick
full_name: Salamin, Yannick
last_name: Salamin
- first_name: Charles
full_name: Roques-Carmes, Charles
id: e2e68fc9-6505-11ef-a541-eb4e72cc3e82
last_name: Roques-Carmes
- first_name: Jamison
full_name: Sloan, Jamison
last_name: Sloan
- first_name: Michael
full_name: Horodynski, Michael
last_name: Horodynski
- first_name: Marin
full_name: Soljačić, Marin
last_name: Soljačić
citation:
ama: Choi S, Salamin Y, Roques-Carmes C, Sloan J, Horodynski M, Soljačić M. Observing
the dynamics of quantum states generated inside nonlinear optical cavities. Nature
Communications. 2025;16. doi:10.1038/s41467-025-63035-8
apa: Choi, S., Salamin, Y., Roques-Carmes, C., Sloan, J., Horodynski, M., &
Soljačić, M. (2025). Observing the dynamics of quantum states generated inside
nonlinear optical cavities. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-025-63035-8
chicago: Choi, Seou, Yannick Salamin, Charles Roques-Carmes, Jamison Sloan, Michael
Horodynski, and Marin Soljačić. “Observing the Dynamics of Quantum States Generated
inside Nonlinear Optical Cavities.” Nature Communications. Springer Nature,
2025. https://doi.org/10.1038/s41467-025-63035-8.
ieee: S. Choi, Y. Salamin, C. Roques-Carmes, J. Sloan, M. Horodynski, and M. Soljačić,
“Observing the dynamics of quantum states generated inside nonlinear optical cavities,”
Nature Communications, vol. 16. Springer Nature, 2025.
ista: Choi S, Salamin Y, Roques-Carmes C, Sloan J, Horodynski M, Soljačić M. 2025.
Observing the dynamics of quantum states generated inside nonlinear optical cavities.
Nature Communications. 16, 7576.
mla: Choi, Seou, et al. “Observing the Dynamics of Quantum States Generated inside
Nonlinear Optical Cavities.” Nature Communications, vol. 16, 7576, Springer
Nature, 2025, doi:10.1038/s41467-025-63035-8.
short: S. Choi, Y. Salamin, C. Roques-Carmes, J. Sloan, M. Horodynski, M. Soljačić,
Nature Communications 16 (2025).
date_created: 2026-03-30T12:22:47Z
date_published: 2025-08-14T00:00:00Z
date_updated: 2026-04-27T08:37:35Z
day: '14'
ddc:
- '530'
doi: 10.1038/s41467-025-63035-8
extern: '1'
external_id:
arxiv:
- '2412.01772'
pmid:
- '40813397'
intvolume: ' 16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41467-025-63035-8
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Observing the dynamics of quantum states generated inside nonlinear optical
cavities
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21542'
abstract:
- lang: eng
text: Nonlinear optics has become the workhorse for countless applications in classical
and quantum optics, from optical bistability to single photon pair generation.
However, the intrinsic weakness of optical nonlinearity and reciprocity of nonlinear
interactions generally places stringent limits on the efficiency of nonlinear
optical processes and their ability to be tailored for advanced applications in
multimode systems. Here, motivated by recent advances in using non-Hermitian photonics
and gain/loss engineering to enable non-reciprocal light transport, we explore
how the interplay between non-Hermiticity and optical nonlinearity leads to a
fundamentally new regime of nonlinear frequency conversion. We show how non-Hermitian
coupling between discrete frequency modes can result in non-reciprocal flow of
energy in a frequency dimension, closely resembling the non-Hermitian skin effect
(NHSE). Applying our theory to a multimode nonlinear cavity supporting cascaded
nonlinear processes, we demonstrate chiral energy flow in a frequency dimension,
leading to long-range frequency shifts of quasi-continuous wave sources, shaped
frequency combs robust to defects and disorder, terahertz (THz) generation far
exceeding the Manley-Rowe limit, and nonlinear multimodal limit cycles for multi-frequency
pump-probe spectroscopy.
article_number: '7544'
article_processing_charge: No
article_type: original
author:
- first_name: Sahil
full_name: Pontula, Sahil
last_name: Pontula
- first_name: Sachin
full_name: Vaidya, Sachin
last_name: Vaidya
- first_name: Charles
full_name: Roques-Carmes, Charles
id: e2e68fc9-6505-11ef-a541-eb4e72cc3e82
last_name: Roques-Carmes
- first_name: Shiekh Zia
full_name: Uddin, Shiekh Zia
last_name: Uddin
- first_name: Marin
full_name: Soljačić, Marin
last_name: Soljačić
- first_name: Yannick
full_name: Salamin, Yannick
last_name: Salamin
citation:
ama: Pontula S, Vaidya S, Roques-Carmes C, Uddin SZ, Soljačić M, Salamin Y. Non-reciprocal
frequency conversion in a non-Hermitian multimode nonlinear system. Nature
Communications. 2025;16. doi:10.1038/s41467-025-62853-0
apa: Pontula, S., Vaidya, S., Roques-Carmes, C., Uddin, S. Z., Soljačić, M., &
Salamin, Y. (2025). Non-reciprocal frequency conversion in a non-Hermitian multimode
nonlinear system. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-025-62853-0
chicago: Pontula, Sahil, Sachin Vaidya, Charles Roques-Carmes, Shiekh Zia Uddin,
Marin Soljačić, and Yannick Salamin. “Non-Reciprocal Frequency Conversion in a
Non-Hermitian Multimode Nonlinear System.” Nature Communications. Springer
Nature, 2025. https://doi.org/10.1038/s41467-025-62853-0.
ieee: S. Pontula, S. Vaidya, C. Roques-Carmes, S. Z. Uddin, M. Soljačić, and Y.
Salamin, “Non-reciprocal frequency conversion in a non-Hermitian multimode nonlinear
system,” Nature Communications, vol. 16. Springer Nature, 2025.
ista: Pontula S, Vaidya S, Roques-Carmes C, Uddin SZ, Soljačić M, Salamin Y. 2025.
Non-reciprocal frequency conversion in a non-Hermitian multimode nonlinear system.
Nature Communications. 16, 7544.
mla: Pontula, Sahil, et al. “Non-Reciprocal Frequency Conversion in a Non-Hermitian
Multimode Nonlinear System.” Nature Communications, vol. 16, 7544, Springer
Nature, 2025, doi:10.1038/s41467-025-62853-0.
short: S. Pontula, S. Vaidya, C. Roques-Carmes, S.Z. Uddin, M. Soljačić, Y. Salamin,
Nature Communications 16 (2025).
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