---
OA_type: closed access
_id: '19994'
abstract:
- lang: eng
  text: Firing patterns of hippocampal principal cells are thought to participate
    in the formation of mnemonic representations of place, which ultimately can be
    used to guide the behavior of animals in space. Past studies have suggested that
    place-selective activity in the hippocampus can emphasize the representation of
    discrete locations associated with a strong behavioral salience. In the first
    part of this book chapter, we review work that has described how that hippocampal
    neuronal activity patterns reorganize during spatial learning. These studies revealed
    that new hippocampal maps emerge during spatial learning to represent the location
    of goal locations and demonstrated that, during recall, the reinstatement of these
    maps predicts successful memory performance. In the second part of this chapter,
    we discuss the role of sleep in memory consolidation in the context of goal-oriented
    spatial learning. We summarize work that has demonstrated the replay of goal-oriented
    neuronal assembly patterns that predict subsequent memory recall. Moreover, we
    argue that the initial strengthening of new maps may in fact take place during
    learning, triggered by waking sharp-wave/ripple patterns occurring at goal locations.
    These reviewed studies highlight that the reorganization and replay of place cell
    firing patterns might constitute a circuit signature for the expression of newly
    acquired hippocampal engrams.
alternative_title:
- Springer Series in Computational Neuroscience
article_processing_charge: No
author:
- first_name: David
  full_name: Dupret, David
  last_name: Dupret
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
citation:
  ama: 'Dupret D, Csicsvari JL. Reorganization of Hippocampal Place-Selective Patterns
    During Goal-Directed Learning and Their Reactivation During Sleep. In: <i>Analysis
    and Modeling of Coordinated Multi-Neuronal Activity</i>. Vol 12. NEUROSCI. Springer
    Nature; 2014. doi:<a href="https://doi.org/10.1007/978-1-4939-1969-7_6">10.1007/978-1-4939-1969-7_6</a>'
  apa: Dupret, D., &#38; Csicsvari, J. L. (2014). Reorganization of Hippocampal Place-Selective
    Patterns During Goal-Directed Learning and Their Reactivation During Sleep. In
    <i>Analysis and Modeling of Coordinated Multi-neuronal Activity</i> (Vol. 12).
    Springer Nature. <a href="https://doi.org/10.1007/978-1-4939-1969-7_6">https://doi.org/10.1007/978-1-4939-1969-7_6</a>
  chicago: Dupret, David, and Jozsef L Csicsvari. “Reorganization of Hippocampal Place-Selective
    Patterns During Goal-Directed Learning and Their Reactivation During Sleep.” In
    <i>Analysis and Modeling of Coordinated Multi-Neuronal Activity</i>, Vol. 12.
    NEUROSCI. Springer Nature, 2014. <a href="https://doi.org/10.1007/978-1-4939-1969-7_6">https://doi.org/10.1007/978-1-4939-1969-7_6</a>.
  ieee: D. Dupret and J. L. Csicsvari, “Reorganization of Hippocampal Place-Selective
    Patterns During Goal-Directed Learning and Their Reactivation During Sleep,” in
    <i>Analysis and Modeling of Coordinated Multi-neuronal Activity</i>, vol. 12,
    Springer Nature, 2014.
  ista: 'Dupret D, Csicsvari JL. 2014.Reorganization of Hippocampal Place-Selective
    Patterns During Goal-Directed Learning and Their Reactivation During Sleep. In:
    Analysis and Modeling of Coordinated Multi-neuronal Activity. Springer Series
    in Computational Neuroscience, vol. 12.'
  mla: Dupret, David, and Jozsef L. Csicsvari. “Reorganization of Hippocampal Place-Selective
    Patterns During Goal-Directed Learning and Their Reactivation During Sleep.” <i>Analysis
    and Modeling of Coordinated Multi-Neuronal Activity</i>, vol. 12, Springer Nature,
    2014, doi:<a href="https://doi.org/10.1007/978-1-4939-1969-7_6">10.1007/978-1-4939-1969-7_6</a>.
  short: D. Dupret, J.L. Csicsvari, in:, Analysis and Modeling of Coordinated Multi-Neuronal
    Activity, Springer Nature, 2014.
date_created: 2025-07-10T14:06:05Z
date_published: 2014-10-30T00:00:00Z
date_updated: 2025-09-23T09:36:44Z
day: '30'
department:
- _id: JoCs
doi: 10.1007/978-1-4939-1969-7_6
intvolume: '        12'
language:
- iso: eng
month: '10'
oa_version: None
publication: Analysis and Modeling of Coordinated Multi-neuronal Activity
publication_identifier:
  eisbn:
  - '9781493919697'
  eissn:
  - 2197-1919
  isbn:
  - '9781493919680'
  issn:
  - 2197-1900
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
series_title: NEUROSCI
status: public
title: Reorganization of Hippocampal Place-Selective Patterns During Goal-Directed
  Learning and Their Reactivation During Sleep
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2014'
...