[{"scopus_import":"1","abstract":[{"lang":"eng","text":"Autoantibodies against the protein leucine-rich glioma inactivated 1 (LGI1) cause the most\r\ncommon subtype of autoimmune encephalitis with predominant involvement of the limbic\r\nsystem, associated with seizures and memory deficits. LGI1 and its receptor ADAM22 are part\r\nof a transsynaptic protein complex that includes several proteins involved in presynaptic\r\nneurotransmitter release and postsynaptic glutamate sensing. Autoantibodies against LGI1\r\nincrease excitatory synaptic strength, but studies that genetically disrupt the LGI1-ADAM22\r\ncomplex report a reduction in postsynaptic glutamate receptor-mediated responses. Thus, the\r\nmechanisms underlying the increased synaptic strength induced by LGI1 autoantibodies remain elusive, and the contributions of presynaptic molecules to the LGI1-transsynaptic complex remain unclear. We therefore investigated the presynaptic mechanisms that mediate\r\nautoantibody-induced synaptic strengthening."}],"OA_place":"publisher","oa":1,"pmid":1,"month":"09","publication":"Neurology, Neuroimmunology and Neuroinflammation","date_created":"2024-08-25T22:01:07Z","oa_version":"Published Version","doi":"10.1212/NXI.0000000000200284","citation":{"chicago":"Ritzau-Jost, Andreas, Felix Gsell, Josefine Sell, Stefan Sachs, Jacqueline-Claire Montanaro-Punzengruber, Toni Kirmann, Sebastian Maaß, et al. “LGI1 Autoantibodies Enhance Synaptic Transmission by Presynaptic Kv1 Loss and Increased Action Potential Broadening.” <i>Neurology, Neuroimmunology and Neuroinflammation</i>. Wolters Kluwer, 2024. <a href=\"https://doi.org/10.1212/NXI.0000000000200284\">https://doi.org/10.1212/NXI.0000000000200284</a>.","ieee":"A. Ritzau-Jost <i>et al.</i>, “LGI1 autoantibodies enhance synaptic transmission by presynaptic Kv1 loss and increased action potential broadening,” <i>Neurology, Neuroimmunology and Neuroinflammation</i>, vol. 11, no. 5. Wolters Kluwer, p. e200284, 2024.","apa":"Ritzau-Jost, A., Gsell, F., Sell, J., Sachs, S., Montanaro-Punzengruber, J.-C., Kirmann, T., … Hallermann, S. (2024). LGI1 autoantibodies enhance synaptic transmission by presynaptic Kv1 loss and increased action potential broadening. <i>Neurology, Neuroimmunology and Neuroinflammation</i>. Wolters Kluwer. <a href=\"https://doi.org/10.1212/NXI.0000000000200284\">https://doi.org/10.1212/NXI.0000000000200284</a>","ama":"Ritzau-Jost A, Gsell F, Sell J, et al. LGI1 autoantibodies enhance synaptic transmission by presynaptic Kv1 loss and increased action potential broadening. <i>Neurology, Neuroimmunology and Neuroinflammation</i>. 2024;11(5):e200284. doi:<a href=\"https://doi.org/10.1212/NXI.0000000000200284\">10.1212/NXI.0000000000200284</a>","short":"A. Ritzau-Jost, F. Gsell, J. Sell, S. Sachs, J.-C. Montanaro-Punzengruber, T. Kirmann, S. Maaß, S.R. Irani, C. Werner, C. Geis, M. Sauer, R. Shigemoto, S. Hallermann, Neurology, Neuroimmunology and Neuroinflammation 11 (2024) e200284.","ista":"Ritzau-Jost A, Gsell F, Sell J, Sachs S, Montanaro-Punzengruber J-C, Kirmann T, Maaß S, Irani SR, Werner C, Geis C, Sauer M, Shigemoto R, Hallermann S. 2024. LGI1 autoantibodies enhance synaptic transmission by presynaptic Kv1 loss and increased action potential broadening. Neurology, Neuroimmunology and Neuroinflammation. 11(5), e200284.","mla":"Ritzau-Jost, Andreas, et al. “LGI1 Autoantibodies Enhance Synaptic Transmission by Presynaptic Kv1 Loss and Increased Action Potential Broadening.” <i>Neurology, Neuroimmunology and Neuroinflammation</i>, vol. 11, no. 5, Wolters Kluwer, 2024, p. e200284, doi:<a href=\"https://doi.org/10.1212/NXI.0000000000200284\">10.1212/NXI.0000000000200284</a>."},"_id":"17457","intvolume":"        11","OA_type":"gold","language":[{"iso":"eng"}],"page":"e200284","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"publication_identifier":{"eissn":["2332-7812"]},"acknowledged_ssus":[{"_id":"Bio"},{"_id":"EM-Fac"}],"DOAJ_listed":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","status":"public","related_material":{"link":[{"url":"https://doi.org/10.1101/2023.10.04.560631","relation":"earlier_version"}]},"date_published":"2024-09-01T00:00:00Z","author":[{"full_name":"Ritzau-Jost, Andreas","first_name":"Andreas","last_name":"Ritzau-Jost"},{"full_name":"Gsell, Felix","first_name":"Felix","last_name":"Gsell"},{"full_name":"Sell, Josefine","first_name":"Josefine","last_name":"Sell"},{"last_name":"Sachs","full_name":"Sachs, Stefan","first_name":"Stefan"},{"full_name":"Montanaro-Punzengruber, Jacqueline-Claire","first_name":"Jacqueline-Claire","id":"3786AB44-F248-11E8-B48F-1D18A9856A87","last_name":"Montanaro-Punzengruber"},{"full_name":"Kirmann, Toni","first_name":"Toni","last_name":"Kirmann"},{"last_name":"Maaß","first_name":"Sebastian","full_name":"Maaß, Sebastian"},{"last_name":"Irani","full_name":"Irani, Sarosh R.","first_name":"Sarosh R."},{"first_name":"Christian","full_name":"Werner, Christian","last_name":"Werner"},{"full_name":"Geis, Christian","first_name":"Christian","last_name":"Geis"},{"first_name":"Markus","full_name":"Sauer, Markus","last_name":"Sauer"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi"},{"last_name":"Hallermann","first_name":"Stefan","full_name":"Hallermann, Stefan"}],"quality_controlled":"1","ddc":["570"],"publisher":"Wolters Kluwer","file":[{"relation":"main_file","creator":"dernst","content_type":"application/pdf","file_name":"2024_NeurologyNeuroimmNeuroinflamm_RitzauJost.pdf","file_size":855818,"success":1,"date_created":"2025-01-09T13:42:42Z","file_id":"18815","access_level":"open_access","checksum":"1e6d1230e0387f72752e3268f5330c9e","date_updated":"2025-01-09T13:42:42Z"}],"publication_status":"published","type":"journal_article","date_updated":"2025-09-08T08:59:37Z","has_accepted_license":"1","issue":"5","article_processing_charge":"Yes","department":[{"_id":"RySh"}],"title":"LGI1 autoantibodies enhance synaptic transmission by presynaptic Kv1 loss and increased action potential broadening","day":"01","year":"2024","volume":11,"acknowledgement":"The authors thank Claudia Sommer for expert technical assistance, the Electron Microscopy Facility of IST-Austria for resources, and Tereza Belinova in the Imaging and Optics Facility of IST-Austria for 3D reconstruction. ","isi":1,"file_date_updated":"2025-01-09T13:42:42Z","external_id":{"pmid":["39141878"],"isi":["001291908600001"]},"project":[{"_id":"05970B30-7A3F-11EA-A408-12923DDC885E","name":"LGI1 antibody-induced pathophysiology in synapses","grant_number":"I04638"}],"article_type":"original"}]