@article{21340,
  abstract     = {Equilibrium quantum systems are often described by a gas of weakly interacting normal modes. Bringing such systems far from equilibrium, however, can drastically enhance mode-to-mode interactions. Understanding the resulting liquid is a fundamental question for quantum statistical mechanics and a practical question for engineering driven quantum devices. To tackle this question, we probe the non-equilibrium kinetics of one-dimensional plasmons in a long chain of Josephson junctions. We introduce multimode spectroscopy to controllably study the departure from equilibrium, witnessing the evolution from pairwise coupling between plasma modes at weak driving to dramatic, high-order, cascaded couplings at strong driving. Scaling to many-mode drives, we stimulate interactions between hundreds of modes, resulting in near-continuum internal dynamics. Imaging the resulting non-equilibrium plasmon populations, we then resolve the nonlocal redistribution of energy in the response to a weak perturbation—an explicit verification of the emergence of a strongly interacting, non-equilibrium liquid of plasmons.},
  author       = {Bubis, Anton and Vigliotti, Lucia and Serbyn, Maksym and Higginbotham, Andrew P},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {7},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Non-equilibrium plasmon liquid in a Josephson junction chain}},
  doi          = {10.1126/sciadv.ady7222},
  volume       = {12},
  year         = {2026},
}

@article{21383,
  abstract     = {Planarian flatworms are known for their remarkable regenerative capacity; however, the precise intercellular communication mechanisms underlying this process remain unsolved. Here, we report the discovery and characterization of abundant extracellular vesicles (EVs) in planarians. Using imaging and molecular analysis, we show conservation of biogenesis, morphology, and protein composition of planarian EVs. Environmental stressors significantly elevate EV release, indicating that planarians dynamically regulate vesicle production. Functionally, planarian EVs mediate intercellular communication by transferring regulatory signals: We find that they shuttle small RNAs that effect systemic RNA interference (RNAi) throughout the organism. Notably, gene knockdown experiments reveal a crucial role for AGO-3, a member of the Argonaute family of proteins, in modulating the association of small interfering RNAs with EVs, linking the intracellular RNAi machinery to EV-based signaling. These findings highlight EVs as pivotal mediators of cell-cell communication in planarians, with broad implications for understanding the coordination of gene regulation and tissue regeneration in animals.},
  author       = {Sasidharan, Vidyanand and Ancellotti, Laura and Doddihal, Viraj and Brewster, Carolyn and Mann, Frederick and McKinney, Mary Cathleen and Varberg, Joseph and Ross, Eric and Deng, Fengyan and Yi, Kexi and Sánchez Alvarado, Alejandro},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {6},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians}},
  doi          = {10.1126/sciadv.ady1461},
  volume       = {12},
  year         = {2026},
}

@article{21707,
  abstract     = {Structural and functional differences between brain hemispheres are a common feature of animal nervous systems with reduced bilateral asymmetry often linked to impaired cognitive performance. How neuronal left-right asymmetry is initiated and integrated into a bilaterally symmetrical ground pattern is poorly understood. Here, we show that the directional asymmetry of a Drosophila central brain circuit originates from axonal interactions of two types of bilateral pioneer neurons. Subsequent recruitment of neighboring neurons into the asymmetric neuropil primordium results in hemisphere-specific microcircuits. Circuit lateralization requires dynamic expression of the cell adhesion molecule Fasciclin 2 to maintain structural plasticity in axonal remodeling. Reduced circuit asymmetry following cell type–specific Fasciclin 2 manipulation affects adult brain function. These results reveal an unexpected degree of developmental plasticity of late-born Drosophila neurons in the formation of a circuit node via the lateralized recruitment of symmetric circuit components.},
  author       = {Markovitsch, Johann W. and Mitić, Daniel and Del Pilar Jiménez García, Alisa and Zane, Alsberga and Kainz, Sarah and Kaur, Rashmit and Hummel, Thomas},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {13},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Sequential formation of Drosophila circuit asymmetry via prolonged structural plasticity}},
  doi          = {10.1126/sciadv.aea6020},
  volume       = {12},
  year         = {2026},
}

@article{21750,
  abstract     = {Liquid-like superionic conductors, with highly mobile ions in a rigid framework, offer intrinsically low lattice thermal conductivity without compromising electronic transport. Argyrodite-type Ag8SnSe6 exhibits a melt-like Ag sublattice that drives lattice thermal conductivity (κL) below 0.2 watts per meter per kelvin, yet its low carrier concentration limits the power factor. Here, interstitial Ag atoms raise the Fermi level into the conduction band, substantially increasing the electron concentration. Simultaneously, the formation of a secondary Ag2Se phase generates lattice distortions that enhance phonon scattering. A pronounced mismatch between electronic (~200 nanometers) and phononic (~0.22 nanometers) mean free paths decouples charge and heat transport, enabling concurrent suppression of κL and retention of high electrical conductivity. This coupled electronic-phononic modulation yields a record ZT of 0.72 at ambient temperature and a peak ZT of 1.1 at 735 kelvins, with an average ZTavg of 0.72 over 320 to 735 kelvins. A unicouple device achieves 6.3% efficiency under a 357-kelvin gradient, highlighting a practical strategy for high-performance midtemperature thermoelectrics.},
  author       = {Li, Mengyao and Zhao, Xueke and Zhang, Yu and Yu, Jing and Liu, Xuyang and Jia, Mochen and Song, Hongzhang and Wang, Dongyang and Arbiol, Jordi and Ibáñez, Maria and Shan, Chongxin and Cabot, Andreu and Wang, Ziyu},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {15},
  publisher    = {AAAS},
  title        = {{Electronic-phononic decoupling and Fermi-level tuning enable high thermoelectric performance in Ag8SnSe6}},
  doi          = {10.1126/sciadv.aec9073},
  volume       = {12},
  year         = {2026},
}

@article{21914,
  abstract     = {Cyclic adenosine monophosphate (cAMP) is a fundamental second messenger involved in diverse signaling pathways across both animals and plants. While the role of 3′,5′-cAMP has been extensively characterized, the biological significance of its structural isomer, 2′,3′-cAMP, remains largely unexplored, particularly in plants. Here, we show that 2′,3′-cAMP and 3′,5′-cAMP represent parallel signaling systems in Arabidopsis thaliana, with different enzymatic origins and largely distinct downstream effects. In vitro enzymatic assays show that plant adenylate cyclases (ACs), including AFB5 and HpAC1, produce specifically 3′,5′-cAMP from ATP, whereas the TIR domain of protein L7 also catalyzes the formation of 2′,3′-cAMP from RNA. Comprehensive multiomics analyses reveal that two isomers elicit distinct yet partially overlapping metabolic, proteomic, and transcriptional response: 2′,3′-cAMP activates broad, stress-adaptive gene expression reprogramming, while 3′,5′-cAMP fine-tunes responses related to nutrient status and cellular homeostasis. Our findings establish the existence of dual cAMP signaling systems in plants, each with specialized functions and provide insights into the complex regulatory networks governing plant physiology.},
  author       = {Li, Mingyue and Chodasiewicz, Monika and Muraleedharan, Malavika and Lopez, Israel M. and Gorka, Michal and Kerber, Olga and Alotaibi, Saqer S. and Nelson, Andrew D.L. and Lenobel, Rene and Friedecká, Jaroslava and Skirycz, Aleksandra and Friml, Jiří},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {19},
  publisher    = {AAAS},
  title        = {{Biogenesis and downstream effects of 3',5' and 2',3' cAMP isomers in plants}},
  doi          = {10.1126/sciadv.aea7828},
  volume       = {12},
  year         = {2026},
}

@article{20220,
  abstract     = {Stress granules (SG) are biomolecular condensates that represent an adaptive response of cells to various stresses, including heat. However, the cell type–specific function and relevance of SG formation, especially during reproductive development, are largely not understood. Here, we show that the meiotic A-type cyclin TARDY ASYNCHRONOUS MEIOSIS (TAM) is recruited to SGs in male meiocytes of Arabidopsis after exposure to heat. We find that the amino terminus of TAM is necessary and sufficient for the localization of proteins to meiotic SGs. Swapping the amino terminus of TAM with the one of its sister protein CYCA1;1 resulted in a separation-of-function allele of TAM, which prevents the partitioning of TAM to SGs while restoring a wild-type phenotype in a tam mutant background under nonheat stress conditions. Notably, plants expressing this TAM version prematurely terminate meiosis under heat resulting in unreduced gametes. Thus, the formation of TAM-containing SGs is necessary for genome stability under heat stress.},
  author       = {De Jaeger-Braet, Joke G and Hartmann, Merle and Böttger, Lev and Yang, Chao and Hamada, Takahiro and Hoth, Stefan and Feng, Xiaoqi and Weingartner, Magdalena and Schnittger, Arp},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {32},
  pages        = {eadr5694},
  publisher    = {AAAS},
  title        = {{The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat}},
  doi          = {10.1126/sciadv.adr5694},
  volume       = {11},
  year         = {2025},
}

@article{20351,
  abstract     = {Rab GTPases organize intracellular trafficking and provide identity to organelles. Their spatiotemporal activation by guanine nucleotide exchange factors (GEFs) is tightly controlled to ensure fidelity. Our structural and functional comparison of the tri-longin domain RabGEFs Mon1-Ccz1 and Fuzzy-Inturned reveals the molecular basis for their target specificity. Both complexes rely on a conserved sequence motif of their substrate GTPases for the catalytic mechanism, while secondary interactions allow discrimination between targets. We also find that dimeric Mon1-Ccz1 from fungi and the metazoan homologs with the additional third subunit RMC1/Bulli bind membranes through electrostatic interactions via distinct interfaces. Protein-lipid interaction studies and functional characterization in flies reveal an essential function of RMC1/Bulli as mediator of GEF complex membrane recruitment. In the case of Fuzzy-Inturned, reconstitution experiments demonstrate that the BAR (Bin-Amphiphysin-Rvs) domain protein CiBAR1 can support membrane recruitment of the GEF. Collectively, our study demonstrates the molecular basis for the adaptation of TLD-RabGEFs to different cellular functions.},
  author       = {Wilmes, Stephan and Tönjes, Jesse and Drechsler, Maik and Ruf, Anita and Schäfer, Jan Hannes and Lürick, Anna and Januliene, Dovile and Apelt, Steven and Di Iorio, Daniele and Wegner, Seraphine V. and Loose, Martin and Moeller, Arne and Paululat, Achim and Kümmel, Daniel},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {35},
  pages        = {eadx2893},
  publisher    = {AAAS},
  title        = {{Mechanistic adaptation of the metazoan RabGEFs Mon1-Ccz1 and Fuzzy-Inturned}},
  doi          = {10.1126/sciadv.adx2893},
  volume       = {11},
  year         = {2025},
}

@article{19277,
  abstract     = {Light-driven molecular rotary motors perform chirality-controlled unidirectional rotations fueled by light and heat. This unique function renders them appealing for the construction of dynamic molecular systems, actuating materials, and molecular machines. Achieving a combination of high photoefficiency, visible-light responsiveness, synthetic accessibility, and easy tuning of dynamic properties within a single scaffold is critical for these applications but remains a longstanding challenge. Herein, a series of highly photoefficient visible-light–responsive molecular motors (MMs), featuring various rotary speeds, was obtained by a convenient one-step formylation of their parent motors. This strategy greatly improves all aspects of the performance of MMs—red-shifted wavelengths of excitation, high photoisomerization quantum yields, and high photostationary state distributions of isomers—beyond the state-of-the-art light-responsive MM systems. The development of this late-stage functionalization strategy of MMs opens avenues for the construction of high-performance molecular machines and devices for applications in materials science and biological systems, representing a major advance in the synthetic toolbox of molecular machines.},
  author       = {Sheng, Jinyu and Van Beek, Carlijn L.F. and Stindt, Charlotte N. and Danowski, Wojciech and Jankowska, Joanna and Crespi, Stefano and Pooler, Daisy R.S. and Hilbers, Michiel F. and Buma, Wybren Jan and Feringa, Ben L.},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {8},
  publisher    = {AAAS},
  title        = {{General strategy for boosting the performance of speed-tunable rotary molecular motors with visible light}},
  doi          = {10.1126/sciadv.adr9326},
  volume       = {11},
  year         = {2025},
}

@article{19282,
  abstract     = {Osmium complexes with osmium in different oxidation states (II, III, IV, and VI) have been reported to exhibit antiproliferative activity in cancer cell lines. Herein, we demonstrate unexplored opportunities offered by 187Os nuclear forward scattering (NFS) and nuclear inelastic scattering (NIS) of synchrotron radiation for characterization of hyperfine interactions and lattice dynamics in a benchmark Os(VI) complex, K2[OsO2(OH)4]. We determined the isomer shift [δ = 3.3(1) millimeters per second] relative to [OsIVCl6]2− and quadrupole splitting [ΔEQ = 12.0(2) millimeters per second] with NFS. We estimated the Lamb-Mössbauer factor [0.80(4)], extracted the density of phonon states, and carried out a thermodynamics characterization using the NIS data combined with first-principles calculations. Overall, we provide evidence that 187Os nuclear resonance scattering is a reliable technique for the investigation of hyperfine interactions and Os-specific vibrations in osmium(VI) species and is thus applicable for such measurements in osmium complexes of other oxidation states, including those with anticancer activity such as Os(III) and Os(IV).},
  author       = {Stepanenko, Iryna and Huang, Zhishuo and Ungur, Liviu and Bessas, Dimitrios and Chumakov, Aleksandr and Sergueev, Ilya and Büchel, Gabriel E. and Al-Kahtani, Abdullah A. and Chibotaru, Liviu F. and Telser, Joshua and Arion, Vladimir B.},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {6},
  publisher    = {AAAS},
  title        = {{187Os nuclear resonance scattering to explore hyperfine interactions and lattice dynamics for biological applications}},
  doi          = {10.1126/sciadv.ads3406},
  volume       = {11},
  year         = {2025},
}

@article{19663,
  abstract     = {The centrosome is a microtubule orchestrator, nucleating and anchoring microtubules that grow radially and exert forces on cargos. At the same time, mechanical stresses from the microenvironment and cellular shape changes compress and bend microtubules. Yet, centrosomes are membraneless organelles, raising the question of how centrosomes withstand mechanical forces. Here, we discover that centrosomes can deform and even fracture. We reveal that centrosomes experience deformations during navigational pathfinding within motile cells. Coherence of the centrosome is maintained by Dyrk3 and cNAP1, preventing fracturing by forces. While cells can compensate for the depletion of centriolar-based centrosomes, the fracturing of centrosomes impedes cellular function by generating coexisting microtubule organizing centers that compete during path navigation and thereby cause cellular entanglement in the microenvironment. Our findings show that cells actively maintain the integrity of the centrosome to withstand mechanical forces. These results suggest that centrosome stability preservation is fundamental, given that almost all cells in multicellular organisms experience forces.},
  author       = {Schmitt, Madeleine T. and Kroll, Janina and Ruiz-Fernandez, Mauricio J.A. and Hauschild, Robert and Ghosh, Shaunak and Kameritsch, Petra and Merrin, Jack and Schmid, Johanna and Stefanowski, Kasia and Thomae, Andreas W. and Cheng, Jingyuan and Öztan, Gamze Naz and Konopka, Peter and Ortega, Germán Camargo and Penz, Thomas and Bach, Luisa and Baumjohann, Dirk and Bock, Christoph and Straub, Tobias and Meissner, Felix and Kiermaier, Eva and Renkawitz, Jörg},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {17},
  publisher    = {AAAS},
  title        = {{Protecting centrosomes from fracturing enables efficient cell navigation}},
  doi          = {10.1126/sciadv.adx4047},
  volume       = {11},
  year         = {2025},
}

@article{18920,
  abstract     = {The globally distributed marine alga Emiliania huxleyi has cooling effect on the Earth’s climate. The population density of E. huxleyi is restricted by Nucleocytoviricota viruses, including E. huxleyi virus 201 (EhV-201). Despite the impact of E. huxleyi viruses on the climate, there is limited information about their structure and replication. Here, we show that the dsDNA genome inside the EhV-201 virion is protected by an inner membrane, capsid, and outer membrane. EhV-201 virions infect E. huxleyi by using fivefold vertices to bind to and fuse the virus’ inner membrane with the cell plasma membrane. Progeny virions assemble in the cytoplasm at the surface of endoplasmic reticulum–derived membrane segments. Genome packaging initiates synchronously with the capsid assembly and completes through an aperture in the forming capsid. The genome-filled capsids acquire an outer membrane by budding into intracellular vesicles. EhV-201 infection induces a loss of surface protective layers from E. huxleyi cells, which enables the continuous release of virions by exocytosis.},
  author       = {Homola, Miroslav and Büttner, Renate Carina and Füzik, Tibor and Křepelka, Pavel and Holbová, Radka and Nováček, Jiří and Chaillet, Marten L. and Žák, Jakub and Grybchuk, Danyil and Förster, Friedrich and Wilson, William H. and Schroeder, Declan C. and Plevka, Pavel},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {15},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Structure and replication cycle of a virus infecting climate-modulating alga Emiliania huxleyi}},
  doi          = {10.1126/sciadv.adk1954},
  volume       = {10},
  year         = {2024},
}

@article{15047,
  abstract     = {Tropical precipitation extremes and their changes with surface warming are investigated using global storm resolving simulations and high-resolution observations. The simulations demonstrate that the mesoscale organization of convection, a process that cannot be physically represented by conventional global climate models, is important for the variations of tropical daily accumulated precipitation extremes. In both the simulations and observations, daily precipitation extremes increase in a more organized state, in association with larger, but less frequent, storms. Repeating the simulations for a warmer climate results in a robust increase in monthly-mean daily precipitation extremes. Higher precipitation percentiles have a greater sensitivity to convective organization, which is predicted to increase with warming. Without changes in organization, the strongest daily precipitation extremes over the tropical oceans increase at a rate close to Clausius-Clapeyron (CC) scaling. Thus, in a future warmer state with increased organization, the strongest daily precipitation extremes over oceans increase at a faster rate than CC scaling.},
  author       = {Bao, Jiawei and Stevens, Bjorn and Kluft, Lukas and Muller, Caroline J},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {8},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Intensification of daily tropical precipitation extremes from more organized convection}},
  doi          = {10.1126/sciadv.adj6801},
  volume       = {10},
  year         = {2024},
}

@article{15179,
  abstract     = {The fungal bioluminescence pathway can be reconstituted in other organisms allowing luminescence imaging without exogenously supplied substrate. The pathway starts from hispidin biosynthesis—a step catalyzed by a large fungal polyketide synthase that requires a posttranslational modification for activity. Here, we report identification of alternative compact hispidin synthases encoded by a phylogenetically diverse group of plants. A hybrid bioluminescence pathway that combines plant and fungal genes is more compact, not dependent on availability of machinery for posttranslational modifications, and confers autonomous bioluminescence in yeast, mammalian, and plant hosts. The compact size of plant hispidin synthases enables additional modes of delivery of autoluminescence, such as delivery with viral vectors.},
  author       = {Palkina, Kseniia A. and Karataeva, Tatiana A. and Perfilov, Maxim M. and Fakhranurova, Liliia I. and Markina, Nadezhda M. and Gonzalez Somermeyer, Louisa and Garcia-Perez, Elena and Vazquez-Vilar, Marta and Rodriguez-Rodriguez, Marta and Vazquez-Vilriales, Victor and Shakhova, Ekaterina S. and Mitiouchkina, Tatiana and Belozerova, Olga A. and Kovalchuk, Sergey I. and Alekberova, Anna and Malyshevskaia, Alena K. and Bugaeva, Evgenia N. and Guglya, Elena B. and Balakireva, Anastasia and Sytov, Nikita and Bezlikhotnova, Anastasia and Boldyreva, Daria I. and Babenko, Vladislav V. and Kondrashov, Fyodor and Choob, Vladimir V. and Orzaez, Diego and Yampolsky, Ilia V. and Mishin, Alexander S. and Sarkisyan, Karen S.},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {10},
  publisher    = {American Association for the Advancement of Science},
  title        = {{A hybrid pathway for self-sustained luminescence}},
  doi          = {10.1126/sciadv.adk1992},
  volume       = {10},
  year         = {2024},
}

@article{17280,
  abstract     = {Adherens junction–associated protein 1 (AJAP1) has been implicated in brain diseases; however, a pathogenic mechanism has not been identified. AJAP1 is widely expressed in neurons and binds to γ-aminobutyric acid type B receptors (GBRs), which inhibit neurotransmitter release at most synapses in the brain. Here, we show that AJAP1 is selectively expressed in dendrites and trans-synaptically recruits GBRs to presynaptic sites of neurons expressing AJAP1. We have identified several monoallelic AJAP1 variants in individuals with epilepsy and/or neurodevelopmental disorders. Specifically, we show that the variant p.(W183C) lacks binding to GBRs, resulting in the inability to recruit them. Ultrastructural analysis revealed significantly decreased presynaptic GBR levels in Ajap1−/− and Ajap1W183C/+ mice. Consequently, these mice exhibited reduced GBR-mediated presynaptic inhibition at excitatory and inhibitory synapses, along with impaired synaptic plasticity. Our study reveals that AJAP1 enables the postsynaptic neuron to regulate the level of presynaptic GBR-mediated inhibition, supporting the clinical relevance of loss-of-function AJAP1 variants.},
  author       = {Früh, Simon and Boudkkazi, Sami and Koppensteiner, Peter and Sereikaite, Vita and Chen, Li Yuan and Fernandez-Fernandez, Diego and Rem, Pascal D. and Ulrich, Daniel and Schwenk, Jochen and Chen, Ziyang and Monnier, Elodie Le and Fritzius, Thorsten and Innocenti, Sabrina M. and Besseyrias, Valérie and Trovò, Luca and Stawarski, Michal and Argilli, Emanuela and Sherr, Elliott H. and Van Bon, Bregje and Kamsteeg, Erik Jan and Iascone, Maria and Pilotta, Alba and Cutrì, Maria R. and Azamian, Mahshid S. and Hernández-García, Andrés and Lalani, Seema R. and Rosenfeld, Jill A. and Zhao, Xiaonan and Vogel, Tiphanie P. and Ona, Herda and Scott, Daryl A. and Scheiffele, Peter and Strømgaard, Kristian and Tafti, Mehdi and Gassmann, Martin and Fakler, Bernd and Shigemoto, Ryuichi and Bettler, Bernhard},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {28},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Monoallelic de novo AJAP1 loss-of- function variants disrupt trans-synaptic control of neurotransmitter release}},
  doi          = {10.1126/sciadv.adk5462},
  volume       = {10},
  year         = {2024},
}

@article{18491,
  abstract     = {Predicting the outcomes of adaptation is a major goal of evolutionary biology. When temporal changes in the environment mirror spatial gradients, it opens up the potential for predicting the course of adaptive evolution over time based on patterns of spatial genetic and phenotypic variation. We assessed this approach in a 30-year transplant experiment in the intertidal snail Littorina saxatilis. In 1992, snails were transplanted from a predation-dominated environment to one dominated by wave action. On the basis of spatial patterns, we predicted transitions in shell size and morphology, allele frequencies at positions throughout the genome, and chromosomal rearrangement frequencies. Observed changes closely agreed with predictions and transformation was both dramatic and rapid. Hence, adaptation can be predicted from knowledge of the phenotypic and genetic variation among populations.},
  author       = {Garcia Castillo, Diego Fernando and Barton, Nicholas H and Faria, Rui and Larsson, Jenny and Stankowski, Sean and Butlin, Roger and Johannesson, Kerstin and Westram, Anja M},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {41},
  publisher    = {AAAS},
  title        = {{Predicting rapid adaptation in time from adaptation in space: A 30-year field experiment in marine snails}},
  doi          = {10.1126/sciadv.adp2102},
  volume       = {10},
  year         = {2024},
}

@article{21582,
  abstract     = {Scintillation materials convert high-energy radiation to optical light through a complex multistage process. The last stage of the process is spontaneous light emission, which usually governs and limits the scintillator emission rate and light yield. For decades, scintillator research focused on developing faster-emitting materials or external photonic coatings for improving light yields. Here, we experimentally demonstrate a fundamentally different approach: enhancing the scintillation rate and yield via the Purcell effect, utilizing optical environment engineering to boost spontaneous emission. This enhancement is universally applicable to any scintillating material and dopant when the material’s nanoscale geometry is engineered. We design a thin multilayer nanophotonic scintillator, demonstrating Purcell-enhanced scintillation with 50% enhancement in emission rate and 80% enhancement in light yield. The emission is robust to fabrication disorder, further highlighting its potential for x-ray applications. Our results show prospects for bridging nanophotonics and scintillator science toward reduced radiation dosage and increased resolution for high-energy particle detection.},
  author       = {Kurman, Yaniv and Lahav, Neta and Schuetz, Roman and Shultzman, Avner and Roques-Carmes, Charles and Lifshits, Alon and Zaken, Segev and Lenkiewicz, Tom and Strassberg, Rotem and Be’er, Orr and Bekenstein, Yehonadav and Kaminer, Ido},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {44},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Purcell-enhanced x-ray scintillation}},
  doi          = {10.1126/sciadv.adq6325},
  volume       = {10},
  year         = {2024},
}

@article{12756,
  abstract     = {ESCRT-III family proteins form composite polymers that deform and cut membrane tubes in the context of a wide range of cell biological processes across the tree of life. In reconstituted systems, sequential changes in the composition of ESCRT-III polymers induced by the AAA–adenosine triphosphatase Vps4 have been shown to remodel membranes. However, it is not known how composite ESCRT-III polymers are organized and remodeled in space and time in a cellular context. Taking advantage of the relative simplicity of the ESCRT-III–dependent division system in Sulfolobus acidocaldarius, one of the closest experimentally tractable prokaryotic relatives of eukaryotes, we use super-resolution microscopy, electron microscopy, and computational modeling to show how CdvB/CdvB1/CdvB2 proteins form a precisely patterned composite ESCRT-III division ring, which undergoes stepwise Vps4-dependent disassembly and contracts to cut cells into two. These observations lead us to suggest sequential changes in a patterned composite polymer as a general mechanism of ESCRT-III–dependent membrane remodeling.},
  author       = {Hurtig, Fredrik and Burgers, Thomas C.Q. and Cezanne, Alice and Jiang, Xiuyun and Mol, Frank N. and Traparić, Jovan and Pulschen, Andre Arashiro and Nierhaus, Tim and Tarrason-Risa, Gabriel and Harker-Kirschneck, Lena and Löwe, Jan and Šarić, Anđela and Vlijm, Rifka and Baum, Buzz},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {11},
  publisher    = {American Association for the Advancement of Science},
  title        = {{The patterned assembly and stepwise Vps4-mediated disassembly of composite ESCRT-III polymers drives archaeal cell division}},
  doi          = {10.1126/sciadv.ade5224},
  volume       = {9},
  year         = {2023},
}

@article{13259,
  abstract     = {Plants can regenerate their bodies via de novo establishment of shoot apical meristems (SAMs) from pluripotent callus. Only a small fraction of callus cells is eventually specified into SAMs but the molecular mechanisms underlying fate specification remain obscure. The expression of WUSCHEL (WUS) is an early hallmark of SAM fate acquisition. Here, we show that a WUS paralog, WUSCHEL-RELATED HOMEOBOX 13 (WOX13), negatively regulates SAM formation from callus in Arabidopsis thaliana. WOX13 promotes non-meristematic cell fate via transcriptional repression of WUS and other SAM regulators and activation of cell wall modifiers. Our Quartz-Seq2–based single cell transcriptome revealed that WOX13 plays key roles in determining cellular identity of callus cell population. We propose that reciprocal inhibition between WUS and WOX13 mediates critical cell fate determination in pluripotent cell population, which has a major impact on regeneration efficiency.},
  author       = {Ogura, Nao and Sasagawa, Yohei and Ito, Tasuku and Tameshige, Toshiaki and Kawai, Satomi and Sano, Masaki and Doll, Yuki and Iwase, Akira and Kawamura, Ayako and Suzuki, Takamasa and Nikaido, Itoshi and Sugimoto, Keiko and Ikeuchi, Momoko},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {27},
  pages        = {eadg6983},
  publisher    = {American Association for the Advancement of Science},
  title        = {{WUSCHEL-RELATED HOMEOBOX 13 suppresses de novo shoot regeneration via cell fate control of pluripotent callus}},
  doi          = {10.1126/sciadv.adg6983},
  volume       = {9},
  year         = {2023},
}

@article{13992,
  abstract     = {Understanding the chirality of molecular reaction pathways is essential for a broad range of fundamental and applied sciences. However, the current ability to probe chirality on the time scale of primary processes underlying chemical reactions remains very limited. Here, we demonstrate time-resolved photoelectron circular dichroism (TRPECD) with ultrashort circularly polarized vacuum-ultraviolet (VUV) pulses from a tabletop source. We demonstrate the capabilities of VUV-TRPECD by resolving the chirality changes in time during the photodissociation of atomic iodine from two chiral molecules. We identify several general key features of TRPECD, which include the ability to probe dynamical chirality along the complete photochemical reaction path, the sensitivity to the local chirality of the evolving scattering potential, and the influence of electron scattering off dissociating photofragments. Our results are interpreted by comparison with high-level ab-initio calculations of transient PECDs from molecular photoionization calculations. Our experimental and theoretical techniques define a general approach to femtochirality.},
  author       = {Svoboda, Vít and Ram, Niraghatam Bhargava and Baykusheva, Denitsa Rangelova and Zindel, Daniel and Waters, Max D. J. and Spenger, Benjamin and Ochsner, Manuel and Herburger, Holger and Stohner, Jürgen and Wörner, Hans Jakob},
  issn         = {2375-2548},
  journal      = {Science Advances},
  keywords     = {Multidisciplinary},
  number       = {28},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Femtosecond photoelectron circular dichroism of chemical reactions}},
  doi          = {10.1126/sciadv.abq2811},
  volume       = {8},
  year         = {2022},
}

@article{13995,
  abstract     = {Shape resonances play a central role in many areas of science, but the real-time measurement of the associated many-body dynamics remains challenging. Here, we present measurements of recoil frame angle-resolved photoionization delays in the vicinity of shape resonances of CF4. This technique provides insights into the spatiotemporal photoionization dynamics of molecular shape resonances. We find delays of up to ∼600 as in the ionization out of the highest occupied molecular orbital (HOMO) with a strong dependence on the emission direction and a pronounced asymmetry along the dissociation axis. Comparison with quantum-scattering calculations traces the asymmetries to the interference of a small subset of partial waves at low kinetic energies and, additionally, to the interference of two overlapping shape resonances in the HOMO-1 channel. Our experimental and theoretical results establish a broadly applicable approach to space- and time-resolved photoionization dynamics in the molecular frame.},
  author       = {Heck, Saijoscha and Baykusheva, Denitsa Rangelova and Han, Meng and Ji, Jia-Bao and Perry, Conaill and Gong, Xiaochun and Wörner, Hans Jakob},
  issn         = {2375-2548},
  journal      = {Science Advances},
  keywords     = {Multidisciplinary},
  number       = {49},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Attosecond interferometry of shape resonances in the recoil frame of CF4}},
  doi          = {10.1126/sciadv.abj8121},
  volume       = {7},
  year         = {2021},
}