[{"quality_controlled":"1","status":"public","abstract":[{"lang":"eng","text":"Vaccinia virus–related kinase (VRK) is an evolutionarily conserved nuclear protein kinase. VRK-1, the single Caenorhabditis elegans VRK ortholog, functions in cell division and germline proliferation. However, the role of VRK-1 in postmitotic cells and adult life span remains unknown. Here, we show that VRK-1 increases organismal longevity by activating the cellular energy sensor, AMP-activated protein kinase (AMPK), via direct phosphorylation. We found that overexpression of vrk-1 in the soma of adult C. elegans increased life span and, conversely, inhibition of vrk-1 decreased life span. In addition, vrk-1 was required for longevity conferred by mutations that inhibit C. elegans mitochondrial respiration, which requires AMPK. VRK-1 directly phosphorylated and up-regulated AMPK in both C. elegans and cultured human cells. Thus, our data show that the somatic nuclear kinase, VRK-1, promotes longevity through AMPK activation, and this function appears to be conserved between C. elegans and humans."}],"date_created":"2024-03-04T09:41:57Z","oa":1,"file":[{"file_name":"2020_ScienceAdvances_Park.pdf","date_created":"2024-03-04T09:46:41Z","content_type":"application/pdf","success":1,"relation":"main_file","creator":"dernst","access_level":"open_access","date_updated":"2024-03-04T09:46:41Z","checksum":"a37157cd0de709dce5fe03f4a31cd0b6","file_size":1864415,"file_id":"15058"}],"type":"journal_article","ddc":["570"],"month":"07","title":"VRK-1 extends life span by activation of AMPK via phosphorylation","author":[{"last_name":"Park","first_name":"Sangsoon","full_name":"Park, Sangsoon"},{"first_name":"Murat","last_name":"Artan","orcid":"0000-0001-8945-6992","id":"C407B586-6052-11E9-B3AE-7006E6697425","full_name":"Artan, Murat"},{"full_name":"Han, Seung Hyun","first_name":"Seung Hyun","last_name":"Han"},{"first_name":"Hae-Eun H.","last_name":"Park","full_name":"Park, Hae-Eun H."},{"full_name":"Jung, Yoonji","last_name":"Jung","first_name":"Yoonji"},{"full_name":"Hwang, Ara B.","last_name":"Hwang","first_name":"Ara B."},{"full_name":"Shin, Won Sik","first_name":"Won Sik","last_name":"Shin"},{"first_name":"Kyong-Tai","last_name":"Kim","full_name":"Kim, Kyong-Tai"},{"last_name":"Lee","first_name":"Seung-Jae V.","full_name":"Lee, Seung-Jae V."}],"year":"2020","doi":"10.1126/sciadv.aaw7824","day":"01","article_number":"aaw7824","article_type":"original","publication_status":"published","publisher":"American Association for the Advancement of Science","oa_version":"Published Version","volume":6,"date_published":"2020-07-01T00:00:00Z","publication":"Science Advances","license":"https://creativecommons.org/licenses/by-nc/4.0/","intvolume":"         6","file_date_updated":"2024-03-04T09:46:41Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"This research was supported by grants NRF-2019R1A3B2067745 and NRF-2017R1A5A1015366 funded by the Korean Government (MSIT) through the National Research Foundation (NRF) of Korea to S.-J.V.L. and by grant Basic Science Research Program (No. 2019R1A2C2009440) funded by the Korean Government (MSIT) through the NRF of Korea to K.-T.K. ","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"issue":"27","date_updated":"2024-03-04T09:52:09Z","article_processing_charge":"No","_id":"15057","citation":{"ama":"Park S, Artan M, Han SH, et al. VRK-1 extends life span by activation of AMPK via phosphorylation. <i>Science Advances</i>. 2020;6(27). doi:<a href=\"https://doi.org/10.1126/sciadv.aaw7824\">10.1126/sciadv.aaw7824</a>","mla":"Park, Sangsoon, et al. “VRK-1 Extends Life Span by Activation of AMPK via Phosphorylation.” <i>Science Advances</i>, vol. 6, no. 27, aaw7824, American Association for the Advancement of Science, 2020, doi:<a href=\"https://doi.org/10.1126/sciadv.aaw7824\">10.1126/sciadv.aaw7824</a>.","short":"S. Park, M. Artan, S.H. Han, H.-E.H. Park, Y. Jung, A.B. Hwang, W.S. Shin, K.-T. Kim, S.-J.V. Lee, Science Advances 6 (2020).","ista":"Park S, Artan M, Han SH, Park H-EH, Jung Y, Hwang AB, Shin WS, Kim K-T, Lee S-JV. 2020. VRK-1 extends life span by activation of AMPK via phosphorylation. Science Advances. 6(27), aaw7824.","apa":"Park, S., Artan, M., Han, S. H., Park, H.-E. H., Jung, Y., Hwang, A. B., … Lee, S.-J. V. (2020). VRK-1 extends life span by activation of AMPK via phosphorylation. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.aaw7824\">https://doi.org/10.1126/sciadv.aaw7824</a>","chicago":"Park, Sangsoon, Murat Artan, Seung Hyun Han, Hae-Eun H. Park, Yoonji Jung, Ara B. Hwang, Won Sik Shin, Kyong-Tai Kim, and Seung-Jae V. Lee. “VRK-1 Extends Life Span by Activation of AMPK via Phosphorylation.” <i>Science Advances</i>. American Association for the Advancement of Science, 2020. <a href=\"https://doi.org/10.1126/sciadv.aaw7824\">https://doi.org/10.1126/sciadv.aaw7824</a>.","ieee":"S. Park <i>et al.</i>, “VRK-1 extends life span by activation of AMPK via phosphorylation,” <i>Science Advances</i>, vol. 6, no. 27. American Association for the Advancement of Science, 2020."},"publication_identifier":{"eissn":["2375-2548"]},"department":[{"_id":"MaDe"}],"language":[{"iso":"eng"}],"has_accepted_license":"1"},{"title":"Microwave quantum illumination using a digital receiver","month":"05","related_material":{"link":[{"relation":"press_release","description":"News on IST Homepage","url":"https://ist.ac.at/en/news/scientists-demonstrate-quantum-radar-prototype/"}],"record":[{"id":"9001","relation":"later_version","status":"public"}]},"ddc":["530"],"article_type":"original","article_number":"eabb0451","scopus_import":"1","day":"06","year":"2020","doi":"10.1126/sciadv.abb0451","author":[{"id":"2D25E1F6-F248-11E8-B48F-1D18A9856A87","full_name":"Barzanjeh, Shabir","orcid":"0000-0003-0415-1423","first_name":"Shabir","last_name":"Barzanjeh"},{"first_name":"S.","last_name":"Pirandola","full_name":"Pirandola, S."},{"first_name":"D","last_name":"Vitali","full_name":"Vitali, D"},{"orcid":"0000-0001-8112-028X","last_name":"Fink","first_name":"Johannes M","full_name":"Fink, Johannes M","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87"}],"project":[{"name":"A Fiber Optic Transceiver for Superconducting Qubits","_id":"26336814-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"758053"},{"grant_number":"862644","call_identifier":"H2020","_id":"237CBA6C-32DE-11EA-91FC-C7463DDC885E","name":"Quantum readout techniques and technologies"},{"name":"Microwave-to-Optical Quantum Link: Quantum Teleportation and Quantum Illumination with cavity Optomechanics","call_identifier":"H2020","grant_number":"707438","_id":"258047B6-B435-11E9-9278-68D0E5697425"},{"name":"Hybrid Optomechanical Technologies","_id":"257EB838-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"732894"},{"grant_number":"F07105","_id":"bdb108fd-d553-11ed-ba76-83dc74a9864f","name":"QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration of Superconducting Quantum Circuits"}],"status":"public","quality_controlled":"1","arxiv":1,"corr_author":"1","type":"journal_article","oa":1,"file":[{"file_name":"2020_ScienceAdvances_Barzanjeh.pdf","date_created":"2020-06-02T09:18:36Z","content_type":"application/pdf","creator":"dernst","access_level":"open_access","date_updated":"2020-07-14T12:48:05Z","relation":"main_file","file_id":"7913","checksum":"16fa61cc1951b444ee74c07188cda9da","file_size":795822}],"date_created":"2020-05-31T22:00:49Z","abstract":[{"lang":"eng","text":"Quantum illumination uses entangled signal-idler photon pairs to boost the detection efficiency of low-reflectivity objects in environments with bright thermal noise. Its advantage is particularly evident at low signal powers, a promising feature for applications such as noninvasive biomedical scanning or low-power short-range radar. Here, we experimentally investigate the concept of quantum illumination at microwave frequencies. We generate entangled fields to illuminate a room-temperature object at a distance of 1 m in a free-space detection setup. We implement a digital phase-conjugate receiver based on linear quadrature measurements that outperforms a symmetric classical noise radar in the same conditions, despite the entanglement-breaking signal path. Starting from experimental data, we also simulate the case of perfect idler photon number detection, which results in a quantum advantage compared with the relative classical benchmark. Our results highlight the opportunities and challenges in the way toward a first room-temperature application of microwave quantum circuits."}],"_id":"7910","article_processing_charge":"No","date_updated":"2026-04-15T06:42:37Z","issue":"19","has_accepted_license":"1","language":[{"iso":"eng"}],"department":[{"_id":"JoFi"}],"pmid":1,"citation":{"ama":"Barzanjeh S, Pirandola S, Vitali D, Fink JM. Microwave quantum illumination using a digital receiver. <i>Science Advances</i>. 2020;6(19). doi:<a href=\"https://doi.org/10.1126/sciadv.abb0451\">10.1126/sciadv.abb0451</a>","mla":"Barzanjeh, Shabir, et al. “Microwave Quantum Illumination Using a Digital Receiver.” <i>Science Advances</i>, vol. 6, no. 19, eabb0451, AAAS, 2020, doi:<a href=\"https://doi.org/10.1126/sciadv.abb0451\">10.1126/sciadv.abb0451</a>.","ista":"Barzanjeh S, Pirandola S, Vitali D, Fink JM. 2020. Microwave quantum illumination using a digital receiver. Science Advances. 6(19), eabb0451.","short":"S. Barzanjeh, S. Pirandola, D. Vitali, J.M. Fink, Science Advances 6 (2020).","apa":"Barzanjeh, S., Pirandola, S., Vitali, D., &#38; Fink, J. M. (2020). Microwave quantum illumination using a digital receiver. <i>Science Advances</i>. AAAS. <a href=\"https://doi.org/10.1126/sciadv.abb0451\">https://doi.org/10.1126/sciadv.abb0451</a>","chicago":"Barzanjeh, Shabir, S. Pirandola, D Vitali, and Johannes M Fink. “Microwave Quantum Illumination Using a Digital Receiver.” <i>Science Advances</i>. AAAS, 2020. <a href=\"https://doi.org/10.1126/sciadv.abb0451\">https://doi.org/10.1126/sciadv.abb0451</a>.","ieee":"S. Barzanjeh, S. Pirandola, D. Vitali, and J. M. Fink, “Microwave quantum illumination using a digital receiver,” <i>Science Advances</i>, vol. 6, no. 19. AAAS, 2020."},"publication_identifier":{"eissn":["2375-2548"]},"external_id":{"pmid":["32548249"],"isi":["000531171100045"],"arxiv":["1908.03058"]},"volume":6,"date_published":"2020-05-06T00:00:00Z","oa_version":"Published Version","ec_funded":1,"publisher":"AAAS","publication_status":"published","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"isi":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"         6","file_date_updated":"2020-07-14T12:48:05Z","publication":"Science Advances"},{"month":"12","title":"Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants","ddc":["580"],"related_material":{"record":[{"id":"10083","status":"public","relation":"dissertation_contains"}]},"article_number":"eabc8895","article_type":"original","author":[{"first_name":"Yuzhou","last_name":"Zhang","orcid":"0000-0003-2627-6956","full_name":"Zhang, Yuzhou","id":"3B6137F2-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-7244-7237","last_name":"Rodriguez Solovey","first_name":"Lesia","full_name":"Rodriguez Solovey, Lesia","id":"3922B506-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Li, Lanxin","id":"367EF8FA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5607-272X","first_name":"Lanxin","last_name":"Li"},{"orcid":"0000-0001-7048-4627","first_name":"Xixi","last_name":"Zhang","full_name":"Zhang, Xixi","id":"61A66458-47E9-11EA-85BA-8AEAAF14E49A"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří","first_name":"Jiří","last_name":"Friml","orcid":"0000-0002-8302-7596"}],"project":[{"_id":"261099A6-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"742985","name":"Tracing Evolution of Auxin Transport and Polarity in Plants"},{"name":"Molecular mechanisms of endocytic cargo recognition in plants","call_identifier":"FWF","grant_number":"I03630","_id":"26538374-B435-11E9-9278-68D0E5697425"},{"grant_number":"25351","_id":"26B4D67E-B435-11E9-9278-68D0E5697425","name":"A Case Study of Plant Growth Regulation: Molecular Mechanism of Auxin-mediated Rapid Growth Inhibition in Arabidopsis Root"}],"year":"2020","doi":"10.1126/sciadv.abc8895","day":"11","scopus_import":"1","quality_controlled":"1","status":"public","corr_author":"1","file":[{"relation":"main_file","access_level":"open_access","creator":"dernst","date_updated":"2021-01-07T12:44:33Z","checksum":"5ac2500b191c08ef6dab5327f40ff663","file_size":10578145,"file_id":"8994","file_name":"2020_ScienceAdvances_Zhang.pdf","content_type":"application/pdf","date_created":"2021-01-07T12:44:33Z","success":1}],"oa":1,"type":"journal_article","abstract":[{"text":"Flowering plants display the highest diversity among plant species and have notably shaped terrestrial landscapes. Nonetheless, the evolutionary origin of their unprecedented morphological complexity remains largely an enigma. Here, we show that the coevolution of cis-regulatory and coding regions of PIN-FORMED (PIN) auxin transporters confined their expression to certain cell types and directed their subcellular localization to particular cell sides, which together enabled dynamic auxin gradients across tissues critical to the complex architecture of flowering plants. Extensive intraspecies and interspecies genetic complementation experiments with PINs from green alga up to flowering plant lineages showed that PIN genes underwent three subsequent, critical evolutionary innovations and thus acquired a triple function to regulate the development of three essential components of the flowering plant Arabidopsis: shoot/root, inflorescence, and floral organ. Our work highlights the critical role of functional innovations within the PIN gene family as essential prerequisites for the origin of flowering plants.","lang":"eng"}],"date_created":"2021-01-03T23:01:23Z","date_updated":"2026-04-30T22:31:06Z","article_processing_charge":"No","_id":"8986","issue":"50","language":[{"iso":"eng"}],"has_accepted_license":"1","external_id":{"isi":["000599903600014"],"pmid":["33310852"]},"citation":{"chicago":"Zhang, Yuzhou, Lesia Rodriguez Solovey, Lanxin Li, Xixi Zhang, and Jiří Friml. “Functional Innovations of PIN Auxin Transporters Mark Crucial Evolutionary Transitions during Rise of Flowering Plants.” <i>Science Advances</i>. AAAS, 2020. <a href=\"https://doi.org/10.1126/sciadv.abc8895\">https://doi.org/10.1126/sciadv.abc8895</a>.","ieee":"Y. Zhang, L. Rodriguez Solovey, L. Li, X. Zhang, and J. Friml, “Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants,” <i>Science Advances</i>, vol. 6, no. 50. AAAS, 2020.","apa":"Zhang, Y., Rodriguez Solovey, L., Li, L., Zhang, X., &#38; Friml, J. (2020). Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants. <i>Science Advances</i>. AAAS. <a href=\"https://doi.org/10.1126/sciadv.abc8895\">https://doi.org/10.1126/sciadv.abc8895</a>","ama":"Zhang Y, Rodriguez Solovey L, Li L, Zhang X, Friml J. Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants. <i>Science Advances</i>. 2020;6(50). doi:<a href=\"https://doi.org/10.1126/sciadv.abc8895\">10.1126/sciadv.abc8895</a>","mla":"Zhang, Yuzhou, et al. “Functional Innovations of PIN Auxin Transporters Mark Crucial Evolutionary Transitions during Rise of Flowering Plants.” <i>Science Advances</i>, vol. 6, no. 50, eabc8895, AAAS, 2020, doi:<a href=\"https://doi.org/10.1126/sciadv.abc8895\">10.1126/sciadv.abc8895</a>.","ista":"Zhang Y, Rodriguez Solovey L, Li L, Zhang X, Friml J. 2020. Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants. Science Advances. 6(50), eabc8895.","short":"Y. Zhang, L. Rodriguez Solovey, L. Li, X. Zhang, J. Friml, Science Advances 6 (2020)."},"publication_identifier":{"eissn":["2375-2548"]},"department":[{"_id":"JiFr"}],"pmid":1,"ec_funded":1,"oa_version":"Published Version","date_published":"2020-12-11T00:00:00Z","volume":6,"publication_status":"published","publisher":"AAAS","acknowledgement":"We thank C.Löhne (Botanic Gardens, University of Bonn) for providing us with A. trichopoda. We would like to thank T.Han, A.Mally (IST, Austria), and C.Hartinger (University of Oxford) for constructive comment and careful reading. Funding: The research leading to these results has received funding from the European Union’s Horizon 2020 Research and Innovation Programme (ERC grant agreement number 742985), Austrian Science Fund (FWF, grant number I 3630-B25), DOC Fellowship of the Austrian Academy of Sciences, and IST Fellow program. ","isi":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"publication":"Science Advances","file_date_updated":"2021-01-07T12:44:33Z","intvolume":"         6","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8"},{"publication_status":"published","publisher":"American Association for the Advancement of Science","date_published":"2019-09-18T00:00:00Z","volume":5,"oa_version":"Published Version","file_date_updated":"2020-07-14T12:47:44Z","intvolume":"         5","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publication":"Science Advances","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"isi":1,"issue":"9","_id":"6919","date_updated":"2026-04-03T09:43:31Z","article_processing_charge":"No","publication_identifier":{"eissn":["2375-2548"]},"citation":{"ieee":"C. Qi, G. D. Minin, I. Vercellino, A. Wutz, and V. M. Korkhov, “Structural basis of sterol recognition by human hedgehog receptor PTCH1,” <i>Science Advances</i>, vol. 5, no. 9. American Association for the Advancement of Science, 2019.","chicago":"Qi, Chao, Giulio Di Minin, Irene Vercellino, Anton Wutz, and Volodymyr M. Korkhov. “Structural Basis of Sterol Recognition by Human Hedgehog Receptor PTCH1.” <i>Science Advances</i>. American Association for the Advancement of Science, 2019. <a href=\"https://doi.org/10.1126/sciadv.aaw6490\">https://doi.org/10.1126/sciadv.aaw6490</a>.","apa":"Qi, C., Minin, G. D., Vercellino, I., Wutz, A., &#38; Korkhov, V. M. (2019). Structural basis of sterol recognition by human hedgehog receptor PTCH1. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.aaw6490\">https://doi.org/10.1126/sciadv.aaw6490</a>","ista":"Qi C, Minin GD, Vercellino I, Wutz A, Korkhov VM. 2019. Structural basis of sterol recognition by human hedgehog receptor PTCH1. Science Advances. 5(9), eaaw6490.","short":"C. Qi, G.D. Minin, I. Vercellino, A. Wutz, V.M. Korkhov, Science Advances 5 (2019).","ama":"Qi C, Minin GD, Vercellino I, Wutz A, Korkhov VM. Structural basis of sterol recognition by human hedgehog receptor PTCH1. <i>Science Advances</i>. 2019;5(9). doi:<a href=\"https://doi.org/10.1126/sciadv.aaw6490\">10.1126/sciadv.aaw6490</a>","mla":"Qi, Chao, et al. “Structural Basis of Sterol Recognition by Human Hedgehog Receptor PTCH1.” <i>Science Advances</i>, vol. 5, no. 9, eaaw6490, American Association for the Advancement of Science, 2019, doi:<a href=\"https://doi.org/10.1126/sciadv.aaw6490\">10.1126/sciadv.aaw6490</a>."},"department":[{"_id":"LeSa"}],"external_id":{"isi":["000491128800062"]},"language":[{"iso":"eng"}],"has_accepted_license":"1","status":"public","quality_controlled":"1","date_created":"2019-09-29T22:00:45Z","type":"journal_article","file":[{"file_name":"2019_AAAS_Qi.pdf","content_type":"application/pdf","date_created":"2019-10-02T11:13:54Z","file_id":"6928","checksum":"b2256c9117655bc15f621ba0babf219f","file_size":1236101,"access_level":"open_access","creator":"kschuh","date_updated":"2020-07-14T12:47:44Z","relation":"main_file"}],"oa":1,"ddc":["570"],"title":"Structural basis of sterol recognition by human hedgehog receptor PTCH1","month":"09","day":"18","scopus_import":"1","author":[{"first_name":"Chao","last_name":"Qi","full_name":"Qi, Chao"},{"full_name":"Minin, Giulio Di","last_name":"Minin","first_name":"Giulio Di"},{"first_name":"Irene","last_name":"Vercellino","orcid":"0000-0001-5618-3449","id":"3ED6AF16-F248-11E8-B48F-1D18A9856A87","full_name":"Vercellino, Irene"},{"full_name":"Wutz, Anton","first_name":"Anton","last_name":"Wutz"},{"full_name":"Korkhov, Volodymyr M.","first_name":"Volodymyr M.","last_name":"Korkhov"}],"doi":"10.1126/sciadv.aaw6490","year":"2019","article_number":"eaaw6490"},{"article_processing_charge":"Yes","date_updated":"2024-12-18T07:54:32Z","_id":"17949","issue":"10","OA_place":"publisher","language":[{"iso":"eng"}],"OA_type":"gold","extern":"1","publication_identifier":{"eissn":["2375-2548"]},"citation":{"apa":"Yin, X., Zang, Y., Zhu, L., Low, J. Z., Liu, Z.-F., Cui, J., … Campos, L. M. (2017). A reversible single-molecule switch based on activated antiaromaticity. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.aao2615\">https://doi.org/10.1126/sciadv.aao2615</a>","mla":"Yin, Xiaodong, et al. “A Reversible Single-Molecule Switch Based on Activated Antiaromaticity.” <i>Science Advances</i>, vol. 3, no. 10, aao2615, American Association for the Advancement of Science, 2017, doi:<a href=\"https://doi.org/10.1126/sciadv.aao2615\">10.1126/sciadv.aao2615</a>.","ama":"Yin X, Zang Y, Zhu L, et al. A reversible single-molecule switch based on activated antiaromaticity. <i>Science Advances</i>. 2017;3(10). doi:<a href=\"https://doi.org/10.1126/sciadv.aao2615\">10.1126/sciadv.aao2615</a>","short":"X. Yin, Y. Zang, L. Zhu, J.Z. Low, Z.-F. Liu, J. Cui, J.B. Neaton, L. Venkataraman, L.M. Campos, Science Advances 3 (2017).","ista":"Yin X, Zang Y, Zhu L, Low JZ, Liu Z-F, Cui J, Neaton JB, Venkataraman L, Campos LM. 2017. A reversible single-molecule switch based on activated antiaromaticity. Science Advances. 3(10), aao2615.","chicago":"Yin, Xiaodong, Yaping Zang, Liangliang Zhu, Jonathan Z. Low, Zhen-Fei Liu, Jing Cui, Jeffrey B. Neaton, Latha Venkataraman, and Luis M. Campos. “A Reversible Single-Molecule Switch Based on Activated Antiaromaticity.” <i>Science Advances</i>. American Association for the Advancement of Science, 2017. <a href=\"https://doi.org/10.1126/sciadv.aao2615\">https://doi.org/10.1126/sciadv.aao2615</a>.","ieee":"X. Yin <i>et al.</i>, “A reversible single-molecule switch based on activated antiaromaticity,” <i>Science Advances</i>, vol. 3, no. 10. American Association for the Advancement of Science, 2017."},"oa_version":"Published Version","date_published":"2017-10-01T00:00:00Z","volume":3,"publisher":"American Association for the Advancement of Science","publication_status":"published","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"publication":"Science Advances","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"         3","month":"10","title":"A reversible single-molecule switch based on activated antiaromaticity","related_material":{"link":[{"url":"https://doi.org/10.1126/sciadv.abq0115","relation":"erratum"}]},"article_number":"aao2615","article_type":"original","year":"2017","doi":"10.1126/sciadv.aao2615","author":[{"full_name":"Yin, Xiaodong","last_name":"Yin","first_name":"Xiaodong"},{"full_name":"Zang, Yaping","first_name":"Yaping","last_name":"Zang"},{"full_name":"Zhu, Liangliang","first_name":"Liangliang","last_name":"Zhu"},{"full_name":"Low, Jonathan Z.","last_name":"Low","first_name":"Jonathan Z."},{"full_name":"Liu, Zhen-Fei","last_name":"Liu","first_name":"Zhen-Fei"},{"full_name":"Cui, Jing","last_name":"Cui","first_name":"Jing"},{"full_name":"Neaton, Jeffrey B.","first_name":"Jeffrey B.","last_name":"Neaton"},{"orcid":"0000-0002-6957-6089","first_name":"Latha","last_name":"Venkataraman","id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf","full_name":"Venkataraman, Latha"},{"full_name":"Campos, Luis M.","first_name":"Luis M.","last_name":"Campos"}],"scopus_import":"1","day":"01","DOAJ_listed":"1","quality_controlled":"1","status":"public","oa":1,"type":"journal_article","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1126/sciadv.aao2615"}],"abstract":[{"lang":"eng","text":"Single-molecule electronic devices provide researchers with an unprecedented ability to relate novel physical phenomena to molecular chemical structures. Typically, conjugated aromatic molecular backbones are relied upon to create electronic devices, where the aromaticity of the building blocks is used to enhance conductivity. We capitalize on the classical physical organic chemistry concept of Hückel antiaromaticity by demonstrating a single-molecule switch that exhibits low conductance in the neutral state and, upon electrochemical oxidation, reversibly switches to an antiaromatic high-conducting structure. We form single-molecule devices using the scanning tunneling microscope–based break-junction technique and observe an on/off ratio of ~70 for a thiophenylidene derivative that switches to an antiaromatic state with 6-4-6-π electrons. Through supporting nuclear magnetic resonance measurements, we show that the doubly oxidized core has antiaromatic character and we use density functional theory calculations to rationalize the origin of the high-conductance state for the oxidized single-molecule junction. Together, our work demonstrates how the concept of antiaromaticity can be exploited to create single-molecule devices that are highly conducting."}],"date_created":"2024-09-09T09:12:08Z"}]