[{"article_processing_charge":"Yes","article_number":"abj0127","has_accepted_license":"1","abstract":[{"lang":"eng","text":"Phonon polaritons (PhPs)—light coupled to lattice vibrations—with in-plane hyperbolic dispersion exhibit ray-like propagation with large wave vectors and enhanced density of optical states along certain directions on a surface. As such, they have raised a surge of interest, promising unprecedented manipulation of infrared light at the nanoscale in a planar circuitry. Here, we demonstrate focusing of in-plane hyperbolic PhPs propagating along thin slabs of α-MoO3. To that end, we developed metallic nanoantennas of convex geometries for both efficient launching and focusing of the polaritons. The foci obtained exhibit enhanced near-field confinement and absorption compared to foci produced by in-plane isotropic PhPs. Foci sizes as small as λp/4.5 = λ0/50 were achieved (λp is the polariton wavelength and λ0 is the photon wavelength). Focusing of in-plane hyperbolic polaritons introduces a first and most basic building block developing planar polariton optics using in-plane anisotropic van der Waals materials."}],"license":"https://creativecommons.org/licenses/by-nc/4.0/","ddc":["530"],"file_date_updated":"2021-10-27T14:16:06Z","oa":1,"intvolume":"         7","doi":"10.1126/sciadv.abj0127","scopus_import":"1","citation":{"ama":"Martín-Sánchez J, Duan J, Taboada-Gutiérrez J, et al. Focusing of in-plane hyperbolic polaritons in van der Waals crystals with tailored infrared nanoantennas. <i>Science Advances</i>. 2021;7(41). doi:<a href=\"https://doi.org/10.1126/sciadv.abj0127\">10.1126/sciadv.abj0127</a>","short":"J. Martín-Sánchez, J. Duan, J. Taboada-Gutiérrez, G. Álvarez-Pérez, K.V. Voronin, I. Prieto Gonzalez, W. Ma, Q. Bao, V.S. Volkov, R. Hillenbrand, A.Y. Nikitin, P. Alonso-González, Science Advances 7 (2021).","ieee":"J. Martín-Sánchez <i>et al.</i>, “Focusing of in-plane hyperbolic polaritons in van der Waals crystals with tailored infrared nanoantennas,” <i>Science Advances</i>, vol. 7, no. 41. American Association for the Advancement of Science, 2021.","ista":"Martín-Sánchez J, Duan J, Taboada-Gutiérrez J, Álvarez-Pérez G, Voronin KV, Prieto Gonzalez I, Ma W, Bao Q, Volkov VS, Hillenbrand R, Nikitin AY, Alonso-González P. 2021. Focusing of in-plane hyperbolic polaritons in van der Waals crystals with tailored infrared nanoantennas. Science Advances. 7(41), abj0127.","mla":"Martín-Sánchez, Javier, et al. “Focusing of In-Plane Hyperbolic Polaritons in van Der Waals Crystals with Tailored Infrared Nanoantennas.” <i>Science Advances</i>, vol. 7, no. 41, abj0127, American Association for the Advancement of Science, 2021, doi:<a href=\"https://doi.org/10.1126/sciadv.abj0127\">10.1126/sciadv.abj0127</a>.","chicago":"Martín-Sánchez, Javier, Jiahua Duan, Javier Taboada-Gutiérrez, Gonzalo Álvarez-Pérez, Kirill V. Voronin, Ivan Prieto Gonzalez, Weiliang Ma, et al. “Focusing of In-Plane Hyperbolic Polaritons in van Der Waals Crystals with Tailored Infrared Nanoantennas.” <i>Science Advances</i>. American Association for the Advancement of Science, 2021. <a href=\"https://doi.org/10.1126/sciadv.abj0127\">https://doi.org/10.1126/sciadv.abj0127</a>.","apa":"Martín-Sánchez, J., Duan, J., Taboada-Gutiérrez, J., Álvarez-Pérez, G., Voronin, K. V., Prieto Gonzalez, I., … Alonso-González, P. (2021). Focusing of in-plane hyperbolic polaritons in van der Waals crystals with tailored infrared nanoantennas. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.abj0127\">https://doi.org/10.1126/sciadv.abj0127</a>"},"date_created":"2021-10-24T22:01:33Z","quality_controlled":"1","day":"08","year":"2021","publication":"Science Advances","language":[{"iso":"eng"}],"issue":"41","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_published":"2021-10-08T00:00:00Z","file":[{"creator":"cziletti","file_id":"10189","relation":"main_file","date_updated":"2021-10-27T14:16:06Z","checksum":"0a470ef6a47d2b8a96ede4c4d28cfacd","access_level":"open_access","content_type":"application/pdf","date_created":"2021-10-27T14:16:06Z","success":1,"file_name":"2021_ScienceAdv_Martin-Sanchez.pdf","file_size":2441163}],"author":[{"full_name":"Martín-Sánchez, Javier","last_name":"Martín-Sánchez","first_name":"Javier"},{"last_name":"Duan","full_name":"Duan, Jiahua","first_name":"Jiahua"},{"last_name":"Taboada-Gutiérrez","full_name":"Taboada-Gutiérrez, Javier","first_name":"Javier"},{"full_name":"Álvarez-Pérez, Gonzalo","last_name":"Álvarez-Pérez","first_name":"Gonzalo"},{"last_name":"Voronin","full_name":"Voronin, Kirill V.","first_name":"Kirill V."},{"full_name":"Prieto Gonzalez, Ivan","orcid":"0000-0002-7370-5357","id":"2A307FE2-F248-11E8-B48F-1D18A9856A87","last_name":"Prieto Gonzalez","first_name":"Ivan"},{"first_name":"Weiliang","last_name":"Ma","full_name":"Ma, Weiliang"},{"last_name":"Bao","full_name":"Bao, Qiaoliang","first_name":"Qiaoliang"},{"full_name":"Volkov, Valentyn S.","last_name":"Volkov","first_name":"Valentyn S."},{"first_name":"Rainer","full_name":"Hillenbrand, Rainer","last_name":"Hillenbrand"},{"full_name":"Nikitin, Alexey Y.","last_name":"Nikitin","first_name":"Alexey Y."},{"last_name":"Alonso-González","full_name":"Alonso-González, Pablo","first_name":"Pablo"}],"external_id":{"arxiv":["2103.10852"],"isi":["000704912700024"]},"volume":7,"acknowledgement":"J.M.-S. acknowledges financial support from the Ramón y Cajal Program of the Government of Spain and FSE (RYC2018-026196-I) and the Spanish Ministry of Science and Innovation (State Plan for Scientific and Technical Research and Innovation grant number PID2019-110308GA-I00). P.A.-G. acknowledges support from the European Research Council under starting grant no. 715496, 2DNANOPTICA, and the Spanish Ministry of Science and Innovation (State Plan for Scientific and Technical Research and Innovation grant number PID2019-111156GB-I00). J.T.-G. acknowledges support through the Severo Ochoa Program from the Government of the Principality of Asturias (PA-18-PF-BP17-126). G.A.-P. acknowledges support through the Severo Ochoa Program from the Government of the Principality of Asturias (PA-20-PF-BP19-053). K.V.V. and V.S.V. acknowledge the financial support from the Ministry of Science and Higher Education of the Russian Federation (agreement no. 075-15-2021-606). A.Y.N. acknowledges the Spanish Ministry of Science, Innovation, and Universities (national projects MAT2017-88358-C3-3-R and PID2020-115221GB-C42) and the Basque Department of Education (PIBA-2020-1-0014). R.H. acknowledges financial support from the Spanish Ministry of Science, Innovation, and Universities (national project number RTI2018-094830-B-100 and project number MDM-2016-0618 of the Marie de Maeztu Units of Excellence Program) and the Basque Government (grant number IT1164-19).","status":"public","date_updated":"2026-04-02T13:15:46Z","title":"Focusing of in-plane hyperbolic polaritons in van der Waals crystals with tailored infrared nanoantennas","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)"},"department":[{"_id":"NanoFab"}],"_id":"10177","isi":1,"publication_identifier":{"eissn":["2375-2548"]},"publication_status":"published","type":"journal_article","publisher":"American Association for the Advancement of Science","oa_version":"Published Version","arxiv":1,"month":"10","article_type":"original"},{"volume":7,"external_id":{"pmid":["33811076"],"isi":["000636455600027"]},"author":[{"first_name":"J.","full_name":"Duan, J.","last_name":"Duan"},{"full_name":"Álvarez-Pérez, G.","last_name":"Álvarez-Pérez","first_name":"G."},{"last_name":"Voronin","full_name":"Voronin, K. V.","first_name":"K. V."},{"first_name":"Ivan","orcid":"0000-0002-7370-5357","full_name":"Prieto Gonzalez, Ivan","id":"2A307FE2-F248-11E8-B48F-1D18A9856A87","last_name":"Prieto Gonzalez"},{"last_name":"Taboada-Gutiérrez","full_name":"Taboada-Gutiérrez, J.","first_name":"J."},{"first_name":"V. S.","last_name":"Volkov","full_name":"Volkov, V. S."},{"last_name":"Martín-Sánchez","full_name":"Martín-Sánchez, J.","first_name":"J."},{"last_name":"Nikitin","full_name":"Nikitin, A. Y.","first_name":"A. Y."},{"last_name":"Alonso-González","full_name":"Alonso-González, P.","first_name":"P."}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","file":[{"file_id":"9343","creator":"dernst","relation":"main_file","date_updated":"2021-04-19T11:17:29Z","checksum":"4b383d4a1d484a71bbc64ecf401bbdbb","date_created":"2021-04-19T11:17:29Z","content_type":"application/pdf","access_level":"open_access","success":1,"file_name":"2021_ScienceAdv_Duan.pdf","file_size":717489}],"date_published":"2021-04-02T00:00:00Z","acknowledgement":"G.Á.-P. and J.T.-G. acknowledge support through the Severo Ochoa Program from the government of the Principality of Asturias (grant nos. PA20-PF-BP19-053 and PA-18-PF-BP17-126, respectively). K.V.V. and V.S.V. acknowledge the Ministry of Science and Higher Education of the Russian Federation (no. 0714-2020-0002). J. M.-S. acknowledges financial support through the Ramón y Cajal Program from the government of Spain and FSE (RYC2018-026196-I). A.Y.N. acknowledges the Spanish Ministry of Science, Innovation and Universities (national project no. MAT201788358-C3-3-R), and the Basque Department of Education (PIBA-2020-1-0014). P.A.-G. acknowledges support from the European Research Council under starting grant no. 715496, 2DNANOPTICA. ","status":"public","year":"2021","issue":"14","publication":"Science Advances","language":[{"iso":"eng"}],"doi":"10.1126/sciadv.abf2690","intvolume":"         7","day":"02","date_created":"2021-04-18T22:01:42Z","quality_controlled":"1","citation":{"ista":"Duan J, Álvarez-Pérez G, Voronin KV, Prieto Gonzalez I, Taboada-Gutiérrez J, Volkov VS, Martín-Sánchez J, Nikitin AY, Alonso-González P. 2021. Enabling propagation of anisotropic polaritons along forbidden directions via a topological transition. Science Advances. 7(14), eabf2690.","mla":"Duan, J., et al. “Enabling Propagation of Anisotropic Polaritons along Forbidden Directions via a Topological Transition.” <i>Science Advances</i>, vol. 7, no. 14, eabf2690, AAAS, 2021, doi:<a href=\"https://doi.org/10.1126/sciadv.abf2690\">10.1126/sciadv.abf2690</a>.","chicago":"Duan, J., G. Álvarez-Pérez, K. V. Voronin, Ivan Prieto Gonzalez, J. Taboada-Gutiérrez, V. S. Volkov, J. Martín-Sánchez, A. Y. Nikitin, and P. Alonso-González. “Enabling Propagation of Anisotropic Polaritons along Forbidden Directions via a Topological Transition.” <i>Science Advances</i>. AAAS, 2021. <a href=\"https://doi.org/10.1126/sciadv.abf2690\">https://doi.org/10.1126/sciadv.abf2690</a>.","apa":"Duan, J., Álvarez-Pérez, G., Voronin, K. V., Prieto Gonzalez, I., Taboada-Gutiérrez, J., Volkov, V. S., … Alonso-González, P. (2021). Enabling propagation of anisotropic polaritons along forbidden directions via a topological transition. <i>Science Advances</i>. AAAS. <a href=\"https://doi.org/10.1126/sciadv.abf2690\">https://doi.org/10.1126/sciadv.abf2690</a>","ama":"Duan J, Álvarez-Pérez G, Voronin KV, et al. Enabling propagation of anisotropic polaritons along forbidden directions via a topological transition. <i>Science Advances</i>. 2021;7(14). doi:<a href=\"https://doi.org/10.1126/sciadv.abf2690\">10.1126/sciadv.abf2690</a>","short":"J. Duan, G. Álvarez-Pérez, K.V. Voronin, I. Prieto Gonzalez, J. Taboada-Gutiérrez, V.S. Volkov, J. Martín-Sánchez, A.Y. Nikitin, P. Alonso-González, Science Advances 7 (2021).","ieee":"J. Duan <i>et al.</i>, “Enabling propagation of anisotropic polaritons along forbidden directions via a topological transition,” <i>Science Advances</i>, vol. 7, no. 14. AAAS, 2021."},"scopus_import":"1","has_accepted_license":"1","article_number":"eabf2690","article_processing_charge":"No","oa":1,"file_date_updated":"2021-04-19T11:17:29Z","abstract":[{"text":"Polaritons with directional in-plane propagation and ultralow losses in van der Waals (vdW) crystals promise unprecedented manipulation of light at the nanoscale. However, these polaritons present a crucial limitation: their directional propagation is intrinsically determined by the crystal structure of the host material, imposing forbidden directions of propagation. Here, we demonstrate that directional polaritons (in-plane hyperbolic phonon polaritons) in a vdW crystal (α-phase molybdenum trioxide) can be directed along forbidden directions by inducing an optical topological transition, which emerges when the slab is placed on a substrate with a given negative permittivity (4H–silicon carbide). By visualizing the transition in real space, we observe exotic polaritonic states between mutually orthogonal hyperbolic regimes, which unveil the topological origin of the transition: a gap opening in the dispersion. This work provides insights into optical topological transitions in vdW crystals, which introduce a route to direct light at the nanoscale.","lang":"eng"}],"ddc":["530"],"article_type":"original","month":"04","oa_version":"Published Version","publication_status":"published","type":"journal_article","publisher":"AAAS","pmid":1,"_id":"9334","publication_identifier":{"eissn":["2375-2548"]},"isi":1,"date_updated":"2026-04-02T13:58:21Z","department":[{"_id":"NanoFab"}],"tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)"},"title":"Enabling propagation of anisotropic polaritons along forbidden directions via a topological transition"},{"OA_place":"publisher","publication_identifier":{"eissn":["2375-2548"]},"_id":"19812","pmid":1,"title":"Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"date_updated":"2025-06-10T13:12:09Z","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1126/sciadv.aaz0611"}],"OA_type":"gold","month":"02","article_type":"original","arxiv":1,"publisher":"American Association for the Advancement of Science","publication_status":"published","type":"journal_article","oa_version":"Published Version","scopus_import":"1","quality_controlled":"1","citation":{"ista":"Sunko V, Mazzola F, Kitamura S, Khim S, Kushwaha P, Clark OJ, Watson MD, Marković I, Biswas D, Pourovskii L, Kim TK, Lee T-L, Thakur PK, Rosner H, Georges A, Moessner R, Oka T, Mackenzie AP, King PDC. 2020. Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system. Science Advances. 6(6), aaz0611.","apa":"Sunko, V., Mazzola, F., Kitamura, S., Khim, S., Kushwaha, P., Clark, O. J., … King, P. D. C. (2020). Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.aaz0611\">https://doi.org/10.1126/sciadv.aaz0611</a>","mla":"Sunko, Veronika, et al. “Probing Spin Correlations Using Angle-Resolved Photoemission in a Coupled Metallic/Mott Insulator System.” <i>Science Advances</i>, vol. 6, no. 6, aaz0611, American Association for the Advancement of Science, 2020, doi:<a href=\"https://doi.org/10.1126/sciadv.aaz0611\">10.1126/sciadv.aaz0611</a>.","chicago":"Sunko, Veronika, F. Mazzola, S. Kitamura, S. Khim, P. Kushwaha, O. J. Clark, M. D. Watson, et al. “Probing Spin Correlations Using Angle-Resolved Photoemission in a Coupled Metallic/Mott Insulator System.” <i>Science Advances</i>. American Association for the Advancement of Science, 2020. <a href=\"https://doi.org/10.1126/sciadv.aaz0611\">https://doi.org/10.1126/sciadv.aaz0611</a>.","short":"V. Sunko, F. Mazzola, S. Kitamura, S. Khim, P. Kushwaha, O.J. Clark, M.D. Watson, I. Marković, D. Biswas, L. Pourovskii, T.K. Kim, T.-L. Lee, P.K. Thakur, H. Rosner, A. Georges, R. Moessner, T. Oka, A.P. Mackenzie, P.D.C. King, Science Advances 6 (2020).","ieee":"V. Sunko <i>et al.</i>, “Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system,” <i>Science Advances</i>, vol. 6, no. 6. American Association for the Advancement of Science, 2020.","ama":"Sunko V, Mazzola F, Kitamura S, et al. Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system. <i>Science Advances</i>. 2020;6(6). doi:<a href=\"https://doi.org/10.1126/sciadv.aaz0611\">10.1126/sciadv.aaz0611</a>"},"date_created":"2025-06-10T09:14:20Z","day":"07","intvolume":"         6","doi":"10.1126/sciadv.aaz0611","license":"https://creativecommons.org/licenses/by/4.0/","abstract":[{"lang":"eng","text":"A nearly free electron metal and a Mott insulating state can be thought of as opposite ends of the spectrum of possibilities for the motion of electrons in a solid. Understanding their interaction lies at the heart of the correlated electron problem. In the magnetic oxide metal PdCrO2, nearly free and Mott-localized electrons exist in alternating layers, forming natural heterostructures. Using angle-resolved photoemission spectroscopy, quantitatively supported by a strong coupling analysis, we show that the coupling between these layers leads to an “intertwined” excitation that is a convolution of the charge spectrum of the metallic layer and the spin susceptibility of the Mott layer. Our findings establish PdCrO2 as a model system in which to probe Kondo lattice physics and also open new routes to use the a priori nonmagnetic probe of photoemission to gain insights into the spin susceptibility of correlated electron materials."}],"oa":1,"article_processing_charge":"Yes","article_number":"aaz0611","has_accepted_license":"1","status":"public","date_published":"2020-02-07T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"pmid":["32128385"],"arxiv":["1809.08972"]},"author":[{"id":"23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3","last_name":"Sunko","orcid":"0000-0003-2724-3523","full_name":"Sunko, Veronika","first_name":"Veronika"},{"first_name":"F.","last_name":"Mazzola","full_name":"Mazzola, F."},{"first_name":"S.","last_name":"Kitamura","full_name":"Kitamura, S."},{"full_name":"Khim, S.","last_name":"Khim","first_name":"S."},{"first_name":"P.","last_name":"Kushwaha","full_name":"Kushwaha, P."},{"last_name":"Clark","full_name":"Clark, O. J.","first_name":"O. J."},{"full_name":"Watson, M. D.","last_name":"Watson","first_name":"M. D."},{"last_name":"Marković","full_name":"Marković, I.","first_name":"I."},{"full_name":"Biswas, D.","last_name":"Biswas","first_name":"D."},{"first_name":"L.","last_name":"Pourovskii","full_name":"Pourovskii, L."},{"first_name":"T. K.","full_name":"Kim, T. K.","last_name":"Kim"},{"last_name":"Lee","full_name":"Lee, T.-L.","first_name":"T.-L."},{"first_name":"P. K.","last_name":"Thakur","full_name":"Thakur, P. K."},{"full_name":"Rosner, H.","last_name":"Rosner","first_name":"H."},{"last_name":"Georges","full_name":"Georges, A.","first_name":"A."},{"first_name":"R.","full_name":"Moessner, R.","last_name":"Moessner"},{"first_name":"T.","full_name":"Oka, T.","last_name":"Oka"},{"full_name":"Mackenzie, A. P.","last_name":"Mackenzie","first_name":"A. P."},{"first_name":"P. D. C.","last_name":"King","full_name":"King, P. D. C."}],"extern":"1","volume":6,"language":[{"iso":"eng"}],"publication":"Science Advances","issue":"6","year":"2020"},{"language":[{"iso":"eng"}],"publication":"Science Advances","issue":"27","year":"2020","status":"public","acknowledgement":"This research was supported by grants NRF-2019R1A3B2067745 and NRF-2017R1A5A1015366 funded by the Korean Government (MSIT) through the National Research Foundation (NRF) of Korea to S.-J.V.L. and by grant Basic Science Research Program (No. 2019R1A2C2009440) funded by the Korean Government (MSIT) through the NRF of Korea to K.-T.K. ","file":[{"file_id":"15058","creator":"dernst","relation":"main_file","date_updated":"2024-03-04T09:46:41Z","checksum":"a37157cd0de709dce5fe03f4a31cd0b6","date_created":"2024-03-04T09:46:41Z","content_type":"application/pdf","access_level":"open_access","success":1,"file_name":"2020_ScienceAdvances_Park.pdf","file_size":1864415}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2020-07-01T00:00:00Z","volume":6,"author":[{"full_name":"Park, Sangsoon","last_name":"Park","first_name":"Sangsoon"},{"orcid":"0000-0001-8945-6992","full_name":"Artan, Murat","id":"C407B586-6052-11E9-B3AE-7006E6697425","last_name":"Artan","first_name":"Murat"},{"first_name":"Seung Hyun","last_name":"Han","full_name":"Han, Seung Hyun"},{"first_name":"Hae-Eun H.","last_name":"Park","full_name":"Park, Hae-Eun H."},{"last_name":"Jung","full_name":"Jung, Yoonji","first_name":"Yoonji"},{"first_name":"Ara B.","last_name":"Hwang","full_name":"Hwang, Ara B."},{"first_name":"Won Sik","full_name":"Shin, Won Sik","last_name":"Shin"},{"last_name":"Kim","full_name":"Kim, Kyong-Tai","first_name":"Kyong-Tai"},{"full_name":"Lee, Seung-Jae V.","last_name":"Lee","first_name":"Seung-Jae V."}],"abstract":[{"text":"Vaccinia virus–related kinase (VRK) is an evolutionarily conserved nuclear protein kinase. VRK-1, the single Caenorhabditis elegans VRK ortholog, functions in cell division and germline proliferation. However, the role of VRK-1 in postmitotic cells and adult life span remains unknown. Here, we show that VRK-1 increases organismal longevity by activating the cellular energy sensor, AMP-activated protein kinase (AMPK), via direct phosphorylation. We found that overexpression of vrk-1 in the soma of adult C. elegans increased life span and, conversely, inhibition of vrk-1 decreased life span. In addition, vrk-1 was required for longevity conferred by mutations that inhibit C. elegans mitochondrial respiration, which requires AMPK. VRK-1 directly phosphorylated and up-regulated AMPK in both C. elegans and cultured human cells. Thus, our data show that the somatic nuclear kinase, VRK-1, promotes longevity through AMPK activation, and this function appears to be conserved between C. elegans and humans.","lang":"eng"}],"ddc":["570"],"oa":1,"file_date_updated":"2024-03-04T09:46:41Z","article_number":"aaw7824","article_processing_charge":"No","has_accepted_license":"1","date_created":"2024-03-04T09:41:57Z","quality_controlled":"1","citation":{"apa":"Park, S., Artan, M., Han, S. H., Park, H.-E. H., Jung, Y., Hwang, A. B., … Lee, S.-J. V. (2020). VRK-1 extends life span by activation of AMPK via phosphorylation. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.aaw7824\">https://doi.org/10.1126/sciadv.aaw7824</a>","mla":"Park, Sangsoon, et al. “VRK-1 Extends Life Span by Activation of AMPK via Phosphorylation.” <i>Science Advances</i>, vol. 6, no. 27, aaw7824, American Association for the Advancement of Science, 2020, doi:<a href=\"https://doi.org/10.1126/sciadv.aaw7824\">10.1126/sciadv.aaw7824</a>.","chicago":"Park, Sangsoon, Murat Artan, Seung Hyun Han, Hae-Eun H. Park, Yoonji Jung, Ara B. Hwang, Won Sik Shin, Kyong-Tai Kim, and Seung-Jae V. Lee. “VRK-1 Extends Life Span by Activation of AMPK via Phosphorylation.” <i>Science Advances</i>. American Association for the Advancement of Science, 2020. <a href=\"https://doi.org/10.1126/sciadv.aaw7824\">https://doi.org/10.1126/sciadv.aaw7824</a>.","ista":"Park S, Artan M, Han SH, Park H-EH, Jung Y, Hwang AB, Shin WS, Kim K-T, Lee S-JV. 2020. VRK-1 extends life span by activation of AMPK via phosphorylation. Science Advances. 6(27), aaw7824.","ama":"Park S, Artan M, Han SH, et al. VRK-1 extends life span by activation of AMPK via phosphorylation. <i>Science Advances</i>. 2020;6(27). doi:<a href=\"https://doi.org/10.1126/sciadv.aaw7824\">10.1126/sciadv.aaw7824</a>","short":"S. Park, M. Artan, S.H. Han, H.-E.H. Park, Y. Jung, A.B. Hwang, W.S. Shin, K.-T. Kim, S.-J.V. Lee, Science Advances 6 (2020).","ieee":"S. Park <i>et al.</i>, “VRK-1 extends life span by activation of AMPK via phosphorylation,” <i>Science Advances</i>, vol. 6, no. 27. American Association for the Advancement of Science, 2020."},"day":"01","intvolume":"         6","doi":"10.1126/sciadv.aaw7824","publication_status":"published","type":"journal_article","publisher":"American Association for the Advancement of Science","oa_version":"Published Version","month":"07","article_type":"original","title":"VRK-1 extends life span by activation of AMPK via phosphorylation","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)"},"department":[{"_id":"MaDe"}],"date_updated":"2024-03-04T09:52:09Z","publication_identifier":{"eissn":["2375-2548"]},"_id":"15057"},{"day":"06","corr_author":"1","scopus_import":"1","citation":{"ama":"Barzanjeh S, Pirandola S, Vitali D, Fink JM. Microwave quantum illumination using a digital receiver. <i>Science Advances</i>. 2020;6(19). doi:<a href=\"https://doi.org/10.1126/sciadv.abb0451\">10.1126/sciadv.abb0451</a>","ieee":"S. Barzanjeh, S. Pirandola, D. Vitali, and J. M. Fink, “Microwave quantum illumination using a digital receiver,” <i>Science Advances</i>, vol. 6, no. 19. AAAS, 2020.","short":"S. Barzanjeh, S. Pirandola, D. Vitali, J.M. Fink, Science Advances 6 (2020).","ista":"Barzanjeh S, Pirandola S, Vitali D, Fink JM. 2020. Microwave quantum illumination using a digital receiver. Science Advances. 6(19), eabb0451.","apa":"Barzanjeh, S., Pirandola, S., Vitali, D., &#38; Fink, J. M. (2020). Microwave quantum illumination using a digital receiver. <i>Science Advances</i>. AAAS. <a href=\"https://doi.org/10.1126/sciadv.abb0451\">https://doi.org/10.1126/sciadv.abb0451</a>","chicago":"Barzanjeh, Shabir, S. Pirandola, D Vitali, and Johannes M Fink. “Microwave Quantum Illumination Using a Digital Receiver.” <i>Science Advances</i>. AAAS, 2020. <a href=\"https://doi.org/10.1126/sciadv.abb0451\">https://doi.org/10.1126/sciadv.abb0451</a>.","mla":"Barzanjeh, Shabir, et al. “Microwave Quantum Illumination Using a Digital Receiver.” <i>Science Advances</i>, vol. 6, no. 19, eabb0451, AAAS, 2020, doi:<a href=\"https://doi.org/10.1126/sciadv.abb0451\">10.1126/sciadv.abb0451</a>."},"date_created":"2020-05-31T22:00:49Z","quality_controlled":"1","doi":"10.1126/sciadv.abb0451","intvolume":"         6","related_material":{"link":[{"description":"News on IST Homepage","url":"https://ist.ac.at/en/news/scientists-demonstrate-quantum-radar-prototype/","relation":"press_release"}],"record":[{"relation":"later_version","status":"public","id":"9001"}]},"file_date_updated":"2020-07-14T12:48:05Z","oa":1,"ddc":["530"],"abstract":[{"lang":"eng","text":"Quantum illumination uses entangled signal-idler photon pairs to boost the detection efficiency of low-reflectivity objects in environments with bright thermal noise. Its advantage is particularly evident at low signal powers, a promising feature for applications such as noninvasive biomedical scanning or low-power short-range radar. Here, we experimentally investigate the concept of quantum illumination at microwave frequencies. We generate entangled fields to illuminate a room-temperature object at a distance of 1 m in a free-space detection setup. We implement a digital phase-conjugate receiver based on linear quadrature measurements that outperforms a symmetric classical noise radar in the same conditions, despite the entanglement-breaking signal path. Starting from experimental data, we also simulate the case of perfect idler photon number detection, which results in a quantum advantage compared with the relative classical benchmark. Our results highlight the opportunities and challenges in the way toward a first room-temperature application of microwave quantum circuits."}],"has_accepted_license":"1","article_processing_charge":"No","article_number":"eabb0451","status":"public","author":[{"first_name":"Shabir","id":"2D25E1F6-F248-11E8-B48F-1D18A9856A87","last_name":"Barzanjeh","full_name":"Barzanjeh, Shabir","orcid":"0000-0003-0415-1423"},{"first_name":"S.","last_name":"Pirandola","full_name":"Pirandola, S."},{"full_name":"Vitali, D","last_name":"Vitali","first_name":"D"},{"last_name":"Fink","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8112-028X","full_name":"Fink, Johannes M","first_name":"Johannes M"}],"external_id":{"arxiv":["1908.03058"],"isi":["000531171100045"],"pmid":["32548249"]},"volume":6,"file":[{"date_updated":"2020-07-14T12:48:05Z","file_id":"7913","creator":"dernst","relation":"main_file","file_name":"2020_ScienceAdvances_Barzanjeh.pdf","file_size":795822,"checksum":"16fa61cc1951b444ee74c07188cda9da","date_created":"2020-06-02T09:18:36Z","content_type":"application/pdf","access_level":"open_access"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2020-05-06T00:00:00Z","issue":"19","language":[{"iso":"eng"}],"publication":"Science Advances","year":"2020","publication_identifier":{"eissn":["2375-2548"]},"isi":1,"pmid":1,"ec_funded":1,"_id":"7910","department":[{"_id":"JoFi"}],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"title":"Microwave quantum illumination using a digital receiver","date_updated":"2026-04-15T06:42:37Z","article_type":"original","month":"05","project":[{"name":"A Fiber Optic Transceiver for Superconducting Qubits","grant_number":"758053","call_identifier":"H2020","_id":"26336814-B435-11E9-9278-68D0E5697425"},{"call_identifier":"H2020","grant_number":"862644","name":"Quantum readout techniques and technologies","_id":"237CBA6C-32DE-11EA-91FC-C7463DDC885E"},{"_id":"258047B6-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"707438","name":"Microwave-to-Optical Quantum Link: Quantum Teleportation and Quantum Illumination with cavity Optomechanics"},{"grant_number":"732894","call_identifier":"H2020","name":"Hybrid Optomechanical Technologies","_id":"257EB838-B435-11E9-9278-68D0E5697425"},{"_id":"bdb108fd-d553-11ed-ba76-83dc74a9864f","grant_number":"F07105","name":"QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration of Superconducting Quantum Circuits"}],"arxiv":1,"oa_version":"Published Version","publisher":"AAAS","publication_status":"published","type":"journal_article"},{"article_type":"original","month":"12","project":[{"_id":"261099A6-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"742985","name":"Tracing Evolution of Auxin Transport and Polarity in Plants"},{"_id":"26538374-B435-11E9-9278-68D0E5697425","name":"Molecular mechanisms of endocytic cargo recognition in plants","call_identifier":"FWF","grant_number":"I03630"},{"name":"A Case Study of Plant Growth Regulation: Molecular Mechanism of Auxin-mediated Rapid Growth Inhibition in Arabidopsis Root","grant_number":"25351","_id":"26B4D67E-B435-11E9-9278-68D0E5697425"}],"oa_version":"Published Version","type":"journal_article","publication_status":"published","publisher":"AAAS","publication_identifier":{"eissn":["2375-2548"]},"isi":1,"pmid":1,"ec_funded":1,"_id":"8986","title":"Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)"},"department":[{"_id":"JiFr"}],"date_updated":"2026-06-19T22:31:09Z","acknowledgement":"We thank C.Löhne (Botanic Gardens, University of Bonn) for providing us with A. trichopoda. We would like to thank T.Han, A.Mally (IST, Austria), and C.Hartinger (University of Oxford) for constructive comment and careful reading. Funding: The research leading to these results has received funding from the European Union’s Horizon 2020 Research and Innovation Programme (ERC grant agreement number 742985), Austrian Science Fund (FWF, grant number I 3630-B25), DOC Fellowship of the Austrian Academy of Sciences, and IST Fellow program. ","status":"public","external_id":{"isi":["000599903600014"],"pmid":["33310852"]},"author":[{"full_name":"Zhang, Yuzhou","orcid":"0000-0003-2627-6956","id":"3B6137F2-F248-11E8-B48F-1D18A9856A87","last_name":"Zhang","first_name":"Yuzhou"},{"first_name":"Lesia","id":"3922B506-F248-11E8-B48F-1D18A9856A87","last_name":"Rodriguez Solovey","full_name":"Rodriguez Solovey, Lesia","orcid":"0000-0002-7244-7237"},{"last_name":"Li","id":"367EF8FA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5607-272X","full_name":"Li, Lanxin","first_name":"Lanxin"},{"orcid":"0000-0001-7048-4627","full_name":"Zhang, Xixi","id":"61A66458-47E9-11EA-85BA-8AEAAF14E49A","last_name":"Zhang","first_name":"Xixi"},{"last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří","orcid":"0000-0002-8302-7596","first_name":"Jiří"}],"volume":6,"date_published":"2020-12-11T00:00:00Z","file":[{"date_created":"2021-01-07T12:44:33Z","access_level":"open_access","content_type":"application/pdf","checksum":"5ac2500b191c08ef6dab5327f40ff663","file_size":10578145,"success":1,"file_name":"2020_ScienceAdvances_Zhang.pdf","relation":"main_file","file_id":"8994","creator":"dernst","date_updated":"2021-01-07T12:44:33Z"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","issue":"50","publication":"Science Advances","language":[{"iso":"eng"}],"year":"2020","day":"11","corr_author":"1","scopus_import":"1","quality_controlled":"1","date_created":"2021-01-03T23:01:23Z","citation":{"short":"Y. Zhang, L. Rodriguez Solovey, L. Li, X. Zhang, J. Friml, Science Advances 6 (2020).","ieee":"Y. Zhang, L. Rodriguez Solovey, L. Li, X. Zhang, and J. Friml, “Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants,” <i>Science Advances</i>, vol. 6, no. 50. AAAS, 2020.","ama":"Zhang Y, Rodriguez Solovey L, Li L, Zhang X, Friml J. Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants. <i>Science Advances</i>. 2020;6(50). doi:<a href=\"https://doi.org/10.1126/sciadv.abc8895\">10.1126/sciadv.abc8895</a>","apa":"Zhang, Y., Rodriguez Solovey, L., Li, L., Zhang, X., &#38; Friml, J. (2020). Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants. <i>Science Advances</i>. AAAS. <a href=\"https://doi.org/10.1126/sciadv.abc8895\">https://doi.org/10.1126/sciadv.abc8895</a>","chicago":"Zhang, Yuzhou, Lesia Rodriguez Solovey, Lanxin Li, Xixi Zhang, and Jiří Friml. “Functional Innovations of PIN Auxin Transporters Mark Crucial Evolutionary Transitions during Rise of Flowering Plants.” <i>Science Advances</i>. AAAS, 2020. <a href=\"https://doi.org/10.1126/sciadv.abc8895\">https://doi.org/10.1126/sciadv.abc8895</a>.","mla":"Zhang, Yuzhou, et al. “Functional Innovations of PIN Auxin Transporters Mark Crucial Evolutionary Transitions during Rise of Flowering Plants.” <i>Science Advances</i>, vol. 6, no. 50, eabc8895, AAAS, 2020, doi:<a href=\"https://doi.org/10.1126/sciadv.abc8895\">10.1126/sciadv.abc8895</a>.","ista":"Zhang Y, Rodriguez Solovey L, Li L, Zhang X, Friml J. 2020. Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants. Science Advances. 6(50), eabc8895."},"doi":"10.1126/sciadv.abc8895","intvolume":"         6","related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"10083"}]},"file_date_updated":"2021-01-07T12:44:33Z","oa":1,"abstract":[{"text":"Flowering plants display the highest diversity among plant species and have notably shaped terrestrial landscapes. Nonetheless, the evolutionary origin of their unprecedented morphological complexity remains largely an enigma. Here, we show that the coevolution of cis-regulatory and coding regions of PIN-FORMED (PIN) auxin transporters confined their expression to certain cell types and directed their subcellular localization to particular cell sides, which together enabled dynamic auxin gradients across tissues critical to the complex architecture of flowering plants. Extensive intraspecies and interspecies genetic complementation experiments with PINs from green alga up to flowering plant lineages showed that PIN genes underwent three subsequent, critical evolutionary innovations and thus acquired a triple function to regulate the development of three essential components of the flowering plant Arabidopsis: shoot/root, inflorescence, and floral organ. Our work highlights the critical role of functional innovations within the PIN gene family as essential prerequisites for the origin of flowering plants.","lang":"eng"}],"ddc":["580"],"has_accepted_license":"1","article_processing_charge":"No","article_number":"eabc8895"},{"date_updated":"2026-04-03T09:43:31Z","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)"},"title":"Structural basis of sterol recognition by human hedgehog receptor PTCH1","department":[{"_id":"LeSa"}],"_id":"6919","isi":1,"publication_identifier":{"eissn":["2375-2548"]},"publication_status":"published","publisher":"American Association for the Advancement of Science","type":"journal_article","oa_version":"Published Version","month":"09","article_number":"eaaw6490","article_processing_charge":"No","has_accepted_license":"1","ddc":["570"],"oa":1,"file_date_updated":"2020-07-14T12:47:44Z","intvolume":"         5","doi":"10.1126/sciadv.aaw6490","citation":{"ista":"Qi C, Minin GD, Vercellino I, Wutz A, Korkhov VM. 2019. Structural basis of sterol recognition by human hedgehog receptor PTCH1. Science Advances. 5(9), eaaw6490.","mla":"Qi, Chao, et al. “Structural Basis of Sterol Recognition by Human Hedgehog Receptor PTCH1.” <i>Science Advances</i>, vol. 5, no. 9, eaaw6490, American Association for the Advancement of Science, 2019, doi:<a href=\"https://doi.org/10.1126/sciadv.aaw6490\">10.1126/sciadv.aaw6490</a>.","chicago":"Qi, Chao, Giulio Di Minin, Irene Vercellino, Anton Wutz, and Volodymyr M. Korkhov. “Structural Basis of Sterol Recognition by Human Hedgehog Receptor PTCH1.” <i>Science Advances</i>. American Association for the Advancement of Science, 2019. <a href=\"https://doi.org/10.1126/sciadv.aaw6490\">https://doi.org/10.1126/sciadv.aaw6490</a>.","apa":"Qi, C., Minin, G. D., Vercellino, I., Wutz, A., &#38; Korkhov, V. M. (2019). Structural basis of sterol recognition by human hedgehog receptor PTCH1. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.aaw6490\">https://doi.org/10.1126/sciadv.aaw6490</a>","short":"C. Qi, G.D. Minin, I. Vercellino, A. Wutz, V.M. Korkhov, Science Advances 5 (2019).","ieee":"C. Qi, G. D. Minin, I. Vercellino, A. Wutz, and V. M. Korkhov, “Structural basis of sterol recognition by human hedgehog receptor PTCH1,” <i>Science Advances</i>, vol. 5, no. 9. American Association for the Advancement of Science, 2019.","ama":"Qi C, Minin GD, Vercellino I, Wutz A, Korkhov VM. Structural basis of sterol recognition by human hedgehog receptor PTCH1. <i>Science Advances</i>. 2019;5(9). doi:<a href=\"https://doi.org/10.1126/sciadv.aaw6490\">10.1126/sciadv.aaw6490</a>"},"date_created":"2019-09-29T22:00:45Z","quality_controlled":"1","scopus_import":"1","day":"18","year":"2019","language":[{"iso":"eng"}],"publication":"Science Advances","issue":"9","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_published":"2019-09-18T00:00:00Z","file":[{"date_updated":"2020-07-14T12:47:44Z","relation":"main_file","file_id":"6928","creator":"kschuh","file_size":1236101,"file_name":"2019_AAAS_Qi.pdf","date_created":"2019-10-02T11:13:54Z","access_level":"open_access","content_type":"application/pdf","checksum":"b2256c9117655bc15f621ba0babf219f"}],"volume":5,"external_id":{"isi":["000491128800062"]},"author":[{"first_name":"Chao","last_name":"Qi","full_name":"Qi, Chao"},{"full_name":"Minin, Giulio Di","last_name":"Minin","first_name":"Giulio Di"},{"full_name":"Vercellino, Irene","orcid":"0000-0001-5618-3449","last_name":"Vercellino","id":"3ED6AF16-F248-11E8-B48F-1D18A9856A87","first_name":"Irene"},{"full_name":"Wutz, Anton","last_name":"Wutz","first_name":"Anton"},{"first_name":"Volodymyr M.","full_name":"Korkhov, Volodymyr M.","last_name":"Korkhov"}],"status":"public"},{"year":"2017","language":[{"iso":"eng"}],"publication":"Science Advances","issue":"10","date_published":"2017-10-01T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":3,"extern":"1","author":[{"first_name":"Xiaodong","full_name":"Yin, Xiaodong","last_name":"Yin"},{"first_name":"Yaping","full_name":"Zang, Yaping","last_name":"Zang"},{"first_name":"Liangliang","last_name":"Zhu","full_name":"Zhu, Liangliang"},{"first_name":"Jonathan Z.","full_name":"Low, Jonathan Z.","last_name":"Low"},{"last_name":"Liu","full_name":"Liu, Zhen-Fei","first_name":"Zhen-Fei"},{"last_name":"Cui","full_name":"Cui, Jing","first_name":"Jing"},{"last_name":"Neaton","full_name":"Neaton, Jeffrey B.","first_name":"Jeffrey B."},{"full_name":"Venkataraman, Latha","orcid":"0000-0002-6957-6089","id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf","last_name":"Venkataraman","first_name":"Latha"},{"last_name":"Campos","full_name":"Campos, Luis M.","first_name":"Luis M."}],"status":"public","article_number":"aao2615","article_processing_charge":"Yes","DOAJ_listed":"1","abstract":[{"text":"Single-molecule electronic devices provide researchers with an unprecedented ability to relate novel physical phenomena to molecular chemical structures. Typically, conjugated aromatic molecular backbones are relied upon to create electronic devices, where the aromaticity of the building blocks is used to enhance conductivity. We capitalize on the classical physical organic chemistry concept of Hückel antiaromaticity by demonstrating a single-molecule switch that exhibits low conductance in the neutral state and, upon electrochemical oxidation, reversibly switches to an antiaromatic high-conducting structure. We form single-molecule devices using the scanning tunneling microscope–based break-junction technique and observe an on/off ratio of ~70 for a thiophenylidene derivative that switches to an antiaromatic state with 6-4-6-π electrons. Through supporting nuclear magnetic resonance measurements, we show that the doubly oxidized core has antiaromatic character and we use density functional theory calculations to rationalize the origin of the high-conductance state for the oxidized single-molecule junction. Together, our work demonstrates how the concept of antiaromaticity can be exploited to create single-molecule devices that are highly conducting.","lang":"eng"}],"oa":1,"related_material":{"link":[{"url":"https://doi.org/10.1126/sciadv.abq0115","relation":"erratum"}]},"intvolume":"         3","doi":"10.1126/sciadv.aao2615","date_created":"2024-09-09T09:12:08Z","quality_controlled":"1","citation":{"ista":"Yin X, Zang Y, Zhu L, Low JZ, Liu Z-F, Cui J, Neaton JB, Venkataraman L, Campos LM. 2017. A reversible single-molecule switch based on activated antiaromaticity. Science Advances. 3(10), aao2615.","apa":"Yin, X., Zang, Y., Zhu, L., Low, J. Z., Liu, Z.-F., Cui, J., … Campos, L. M. (2017). A reversible single-molecule switch based on activated antiaromaticity. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.aao2615\">https://doi.org/10.1126/sciadv.aao2615</a>","mla":"Yin, Xiaodong, et al. “A Reversible Single-Molecule Switch Based on Activated Antiaromaticity.” <i>Science Advances</i>, vol. 3, no. 10, aao2615, American Association for the Advancement of Science, 2017, doi:<a href=\"https://doi.org/10.1126/sciadv.aao2615\">10.1126/sciadv.aao2615</a>.","chicago":"Yin, Xiaodong, Yaping Zang, Liangliang Zhu, Jonathan Z. Low, Zhen-Fei Liu, Jing Cui, Jeffrey B. Neaton, Latha Venkataraman, and Luis M. Campos. “A Reversible Single-Molecule Switch Based on Activated Antiaromaticity.” <i>Science Advances</i>. American Association for the Advancement of Science, 2017. <a href=\"https://doi.org/10.1126/sciadv.aao2615\">https://doi.org/10.1126/sciadv.aao2615</a>.","ama":"Yin X, Zang Y, Zhu L, et al. A reversible single-molecule switch based on activated antiaromaticity. <i>Science Advances</i>. 2017;3(10). doi:<a href=\"https://doi.org/10.1126/sciadv.aao2615\">10.1126/sciadv.aao2615</a>","short":"X. Yin, Y. Zang, L. Zhu, J.Z. Low, Z.-F. Liu, J. Cui, J.B. Neaton, L. Venkataraman, L.M. Campos, Science Advances 3 (2017).","ieee":"X. Yin <i>et al.</i>, “A reversible single-molecule switch based on activated antiaromaticity,” <i>Science Advances</i>, vol. 3, no. 10. American Association for the Advancement of Science, 2017."},"scopus_import":"1","day":"01","type":"journal_article","publisher":"American Association for the Advancement of Science","publication_status":"published","oa_version":"Published Version","month":"10","article_type":"original","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1126/sciadv.aao2615"}],"OA_type":"gold","date_updated":"2024-12-18T07:54:32Z","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)"},"title":"A reversible single-molecule switch based on activated antiaromaticity","_id":"17949","OA_place":"publisher","publication_identifier":{"eissn":["2375-2548"]}},{"main_file_link":[{"url":"https://doi.org/10.1126/sciadv.1501860","open_access":"1"}],"OA_type":"gold","article_type":"original","month":"04","oa_version":"Published Version","publication_status":"published","type":"journal_article","publisher":"American Association for the Advancement of Science","publication_identifier":{"eissn":["2375-2548"]},"OA_place":"publisher","pmid":1,"_id":"849","title":"Saturation of recognition elements blocks evolution of new tRNA identities","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)"},"date_updated":"2026-05-20T08:27:46Z","status":"public","acknowledgement":"We thank D. Söll, H. Grosjean, and L. Filonava for comments and suggestions.\r\nM.O. and P.D.D. thank the Barcelona Supercomputing Center for CPU/GPU time on MareNostrum/\r\nMinoTauro. P.D.D. is a PEDECIBA (Programa de Desarrollo de las Ciencias Básicas) and an SNI\r\n(Sistema Nacional de Investigadores) (ANII, Uruguay) researcher. Funding: This work was\r\nsupported in part by the Spanish Ministry of Economy and Competitiveness (grants\r\nBIO2012-32200, Sev-2012-0208, and BIO2012-32868 to L.R.d.P., F.A.K., and M.O., respectively)\r\nand by the Catalan Government (grants 2014-SGR-0771, 2014-SGR-0974, and 2014-SGR-0134 to\r\nL.R.d.P., F.A.K., and M.O., respectively). This work was also supported by the Howard Hughes\r\nMedical Institute International Early Career Scientist Program (55007424), by a European Research\r\nCouncil (ERC) Starting Grant (335980_EinME to F.K.), and by a grant from the ERC (ERC_SimDNA to\r\nM.O). A.G.T. and C.B. are funded by the Spanish Ministry of Economy and Competitiveness\r\n(FPDI-2013-17742 and BES-2013-064004, respectively).","volume":2,"extern":"1","publist_id":"6798","external_id":{"pmid":["27386510"]},"author":[{"first_name":"Adélaïde","full_name":"Saint Léger, Adélaïde","last_name":"Saint Léger"},{"full_name":"Bello, Carla","last_name":"Bello","first_name":"Carla"},{"first_name":"Pablo","last_name":"Dans","full_name":"Dans, Pablo"},{"first_name":"Adrian","last_name":"Torres","full_name":"Torres, Adrian"},{"full_name":"Novoa, Eva","last_name":"Novoa","first_name":"Eva"},{"last_name":"Camacho","full_name":"Camacho, Noelia","first_name":"Noelia"},{"first_name":"Modesto","last_name":"Orozco","full_name":"Orozco, Modesto"},{"id":"44FDEF62-F248-11E8-B48F-1D18A9856A87","last_name":"Kondrashov","orcid":"0000-0001-8243-4694","full_name":"Kondrashov, Fyodor","first_name":"Fyodor"},{"first_name":"Lluís","full_name":"Ribas De Pouplana, Lluís","last_name":"Ribas De Pouplana"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_published":"2016-04-29T00:00:00Z","issue":"4","publication":"Science advances","language":[{"iso":"eng"}],"year":"2016","day":"29","quality_controlled":"1","citation":{"ama":"Saint Léger A, Bello C, Dans P, et al. Saturation of recognition elements blocks evolution of new tRNA identities. <i>Science advances</i>. 2016;2(4). doi:<a href=\"https://doi.org/10.1126/sciadv.1501860\">10.1126/sciadv.1501860</a>","ieee":"A. Saint Léger <i>et al.</i>, “Saturation of recognition elements blocks evolution of new tRNA identities,” <i>Science advances</i>, vol. 2, no. 4. American Association for the Advancement of Science, 2016.","short":"A. Saint Léger, C. Bello, P. Dans, A. Torres, E. Novoa, N. Camacho, M. Orozco, F. Kondrashov, L. Ribas De Pouplana, Science Advances 2 (2016).","mla":"Saint Léger, Adélaïde, et al. “Saturation of Recognition Elements Blocks Evolution of New TRNA Identities.” <i>Science Advances</i>, vol. 2, no. 4, e1501860, American Association for the Advancement of Science, 2016, doi:<a href=\"https://doi.org/10.1126/sciadv.1501860\">10.1126/sciadv.1501860</a>.","chicago":"Saint Léger, Adélaïde, Carla Bello, Pablo Dans, Adrian Torres, Eva Novoa, Noelia Camacho, Modesto Orozco, Fyodor Kondrashov, and Lluís Ribas De Pouplana. “Saturation of Recognition Elements Blocks Evolution of New TRNA Identities.” <i>Science Advances</i>. American Association for the Advancement of Science, 2016. <a href=\"https://doi.org/10.1126/sciadv.1501860\">https://doi.org/10.1126/sciadv.1501860</a>.","apa":"Saint Léger, A., Bello, C., Dans, P., Torres, A., Novoa, E., Camacho, N., … Ribas De Pouplana, L. (2016). Saturation of recognition elements blocks evolution of new tRNA identities. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.1501860\">https://doi.org/10.1126/sciadv.1501860</a>","ista":"Saint Léger A, Bello C, Dans P, Torres A, Novoa E, Camacho N, Orozco M, Kondrashov F, Ribas De Pouplana L. 2016. Saturation of recognition elements blocks evolution of new tRNA identities. Science advances. 2(4), e1501860."},"date_created":"2018-12-11T11:48:50Z","scopus_import":"1","doi":"10.1126/sciadv.1501860","intvolume":"         2","oa":1,"abstract":[{"lang":"eng","text":"Understanding the principles that led to the current complexity of the genetic code is a central question in evolution. Expansion of the genetic code required the selection of new transfer RNAs (tRNAs) with specific recognition signals that allowed them to be matured, modified, aminoacylated, and processed by the ribosome without compromising the fidelity or efficiency of protein synthesis. We show that saturation of recognition signals blocks the emergence of new tRNA identities and that the rate of nucleotide substitutions in tRNAs is higher in species with fewer tRNA genes. We propose that the growth of the genetic code stalled because a limit was reached in the number of identity elements that can be effectively used in the tRNA structure."}],"article_number":"e1501860","article_processing_charge":"No"}]