---
_id: '15057'
abstract:
- lang: eng
  text: Vaccinia virus–related kinase (VRK) is an evolutionarily conserved nuclear
    protein kinase. VRK-1, the single Caenorhabditis elegans VRK ortholog, functions
    in cell division and germline proliferation. However, the role of VRK-1 in postmitotic
    cells and adult life span remains unknown. Here, we show that VRK-1 increases
    organismal longevity by activating the cellular energy sensor, AMP-activated protein
    kinase (AMPK), via direct phosphorylation. We found that overexpression of vrk-1
    in the soma of adult C. elegans increased life span and, conversely, inhibition
    of vrk-1 decreased life span. In addition, vrk-1 was required for longevity conferred
    by mutations that inhibit C. elegans mitochondrial respiration, which requires
    AMPK. VRK-1 directly phosphorylated and up-regulated AMPK in both C. elegans and
    cultured human cells. Thus, our data show that the somatic nuclear kinase, VRK-1,
    promotes longevity through AMPK activation, and this function appears to be conserved
    between C. elegans and humans.
acknowledgement: 'This research was supported by grants NRF-2019R1A3B2067745 and NRF-2017R1A5A1015366
  funded by the Korean Government (MSIT) through the National Research Foundation
  (NRF) of Korea to S.-J.V.L. and by grant Basic Science Research Program (No. 2019R1A2C2009440)
  funded by the Korean Government (MSIT) through the NRF of Korea to K.-T.K. '
article_number: aaw7824
article_processing_charge: No
article_type: original
author:
- first_name: Sangsoon
  full_name: Park, Sangsoon
  last_name: Park
- first_name: Murat
  full_name: Artan, Murat
  id: C407B586-6052-11E9-B3AE-7006E6697425
  last_name: Artan
  orcid: 0000-0001-8945-6992
- first_name: Seung Hyun
  full_name: Han, Seung Hyun
  last_name: Han
- first_name: Hae-Eun H.
  full_name: Park, Hae-Eun H.
  last_name: Park
- first_name: Yoonji
  full_name: Jung, Yoonji
  last_name: Jung
- first_name: Ara B.
  full_name: Hwang, Ara B.
  last_name: Hwang
- first_name: Won Sik
  full_name: Shin, Won Sik
  last_name: Shin
- first_name: Kyong-Tai
  full_name: Kim, Kyong-Tai
  last_name: Kim
- first_name: Seung-Jae V.
  full_name: Lee, Seung-Jae V.
  last_name: Lee
citation:
  ama: Park S, Artan M, Han SH, et al. VRK-1 extends life span by activation of AMPK
    via phosphorylation. <i>Science Advances</i>. 2020;6(27). doi:<a href="https://doi.org/10.1126/sciadv.aaw7824">10.1126/sciadv.aaw7824</a>
  apa: Park, S., Artan, M., Han, S. H., Park, H.-E. H., Jung, Y., Hwang, A. B., …
    Lee, S.-J. V. (2020). VRK-1 extends life span by activation of AMPK via phosphorylation.
    <i>Science Advances</i>. American Association for the Advancement of Science.
    <a href="https://doi.org/10.1126/sciadv.aaw7824">https://doi.org/10.1126/sciadv.aaw7824</a>
  chicago: Park, Sangsoon, Murat Artan, Seung Hyun Han, Hae-Eun H. Park, Yoonji Jung,
    Ara B. Hwang, Won Sik Shin, Kyong-Tai Kim, and Seung-Jae V. Lee. “VRK-1 Extends
    Life Span by Activation of AMPK via Phosphorylation.” <i>Science Advances</i>.
    American Association for the Advancement of Science, 2020. <a href="https://doi.org/10.1126/sciadv.aaw7824">https://doi.org/10.1126/sciadv.aaw7824</a>.
  ieee: S. Park <i>et al.</i>, “VRK-1 extends life span by activation of AMPK via
    phosphorylation,” <i>Science Advances</i>, vol. 6, no. 27. American Association
    for the Advancement of Science, 2020.
  ista: Park S, Artan M, Han SH, Park H-EH, Jung Y, Hwang AB, Shin WS, Kim K-T, Lee
    S-JV. 2020. VRK-1 extends life span by activation of AMPK via phosphorylation.
    Science Advances. 6(27), aaw7824.
  mla: Park, Sangsoon, et al. “VRK-1 Extends Life Span by Activation of AMPK via Phosphorylation.”
    <i>Science Advances</i>, vol. 6, no. 27, aaw7824, American Association for the
    Advancement of Science, 2020, doi:<a href="https://doi.org/10.1126/sciadv.aaw7824">10.1126/sciadv.aaw7824</a>.
  short: S. Park, M. Artan, S.H. Han, H.-E.H. Park, Y. Jung, A.B. Hwang, W.S. Shin,
    K.-T. Kim, S.-J.V. Lee, Science Advances 6 (2020).
date_created: 2024-03-04T09:41:57Z
date_published: 2020-07-01T00:00:00Z
date_updated: 2024-03-04T09:52:09Z
day: '01'
ddc:
- '570'
department:
- _id: MaDe
doi: 10.1126/sciadv.aaw7824
file:
- access_level: open_access
  checksum: a37157cd0de709dce5fe03f4a31cd0b6
  content_type: application/pdf
  creator: dernst
  date_created: 2024-03-04T09:46:41Z
  date_updated: 2024-03-04T09:46:41Z
  file_id: '15058'
  file_name: 2020_ScienceAdvances_Park.pdf
  file_size: 1864415
  relation: main_file
  success: 1
file_date_updated: 2024-03-04T09:46:41Z
has_accepted_license: '1'
intvolume: '         6'
issue: '27'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '07'
oa: 1
oa_version: Published Version
publication: Science Advances
publication_identifier:
  eissn:
  - 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
status: public
title: VRK-1 extends life span by activation of AMPK via phosphorylation
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2020'
...
---
_id: '7910'
abstract:
- lang: eng
  text: Quantum illumination uses entangled signal-idler photon pairs to boost the
    detection efficiency of low-reflectivity objects in environments with bright thermal
    noise. Its advantage is particularly evident at low signal powers, a promising
    feature for applications such as noninvasive biomedical scanning or low-power
    short-range radar. Here, we experimentally investigate the concept of quantum
    illumination at microwave frequencies. We generate entangled fields to illuminate
    a room-temperature object at a distance of 1 m in a free-space detection setup.
    We implement a digital phase-conjugate receiver based on linear quadrature measurements
    that outperforms a symmetric classical noise radar in the same conditions, despite
    the entanglement-breaking signal path. Starting from experimental data, we also
    simulate the case of perfect idler photon number detection, which results in a
    quantum advantage compared with the relative classical benchmark. Our results
    highlight the opportunities and challenges in the way toward a first room-temperature
    application of microwave quantum circuits.
article_number: eabb0451
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Shabir
  full_name: Barzanjeh, Shabir
  id: 2D25E1F6-F248-11E8-B48F-1D18A9856A87
  last_name: Barzanjeh
  orcid: 0000-0003-0415-1423
- first_name: S.
  full_name: Pirandola, S.
  last_name: Pirandola
- first_name: D
  full_name: Vitali, D
  last_name: Vitali
- first_name: Johannes M
  full_name: Fink, Johannes M
  id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
  last_name: Fink
  orcid: 0000-0001-8112-028X
citation:
  ama: Barzanjeh S, Pirandola S, Vitali D, Fink JM. Microwave quantum illumination
    using a digital receiver. <i>Science Advances</i>. 2020;6(19). doi:<a href="https://doi.org/10.1126/sciadv.abb0451">10.1126/sciadv.abb0451</a>
  apa: Barzanjeh, S., Pirandola, S., Vitali, D., &#38; Fink, J. M. (2020). Microwave
    quantum illumination using a digital receiver. <i>Science Advances</i>. AAAS.
    <a href="https://doi.org/10.1126/sciadv.abb0451">https://doi.org/10.1126/sciadv.abb0451</a>
  chicago: Barzanjeh, Shabir, S. Pirandola, D Vitali, and Johannes M Fink. “Microwave
    Quantum Illumination Using a Digital Receiver.” <i>Science Advances</i>. AAAS,
    2020. <a href="https://doi.org/10.1126/sciadv.abb0451">https://doi.org/10.1126/sciadv.abb0451</a>.
  ieee: S. Barzanjeh, S. Pirandola, D. Vitali, and J. M. Fink, “Microwave quantum
    illumination using a digital receiver,” <i>Science Advances</i>, vol. 6, no. 19.
    AAAS, 2020.
  ista: Barzanjeh S, Pirandola S, Vitali D, Fink JM. 2020. Microwave quantum illumination
    using a digital receiver. Science Advances. 6(19), eabb0451.
  mla: Barzanjeh, Shabir, et al. “Microwave Quantum Illumination Using a Digital Receiver.”
    <i>Science Advances</i>, vol. 6, no. 19, eabb0451, AAAS, 2020, doi:<a href="https://doi.org/10.1126/sciadv.abb0451">10.1126/sciadv.abb0451</a>.
  short: S. Barzanjeh, S. Pirandola, D. Vitali, J.M. Fink, Science Advances 6 (2020).
corr_author: '1'
date_created: 2020-05-31T22:00:49Z
date_published: 2020-05-06T00:00:00Z
date_updated: 2026-04-15T06:42:37Z
day: '06'
ddc:
- '530'
department:
- _id: JoFi
doi: 10.1126/sciadv.abb0451
ec_funded: 1
external_id:
  arxiv:
  - '1908.03058'
  isi:
  - '000531171100045'
  pmid:
  - '32548249'
file:
- access_level: open_access
  checksum: 16fa61cc1951b444ee74c07188cda9da
  content_type: application/pdf
  creator: dernst
  date_created: 2020-06-02T09:18:36Z
  date_updated: 2020-07-14T12:48:05Z
  file_id: '7913'
  file_name: 2020_ScienceAdvances_Barzanjeh.pdf
  file_size: 795822
  relation: main_file
file_date_updated: 2020-07-14T12:48:05Z
has_accepted_license: '1'
intvolume: '         6'
isi: 1
issue: '19'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 26336814-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '758053'
  name: A Fiber Optic Transceiver for Superconducting Qubits
- _id: 237CBA6C-32DE-11EA-91FC-C7463DDC885E
  call_identifier: H2020
  grant_number: '862644'
  name: Quantum readout techniques and technologies
- _id: 258047B6-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '707438'
  name: 'Microwave-to-Optical Quantum Link: Quantum Teleportation and Quantum Illumination
    with cavity Optomechanics'
- _id: 257EB838-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '732894'
  name: Hybrid Optomechanical Technologies
- _id: bdb108fd-d553-11ed-ba76-83dc74a9864f
  grant_number: F07105
  name: QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration
    of Superconducting Quantum Circuits
publication: Science Advances
publication_identifier:
  eissn:
  - 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/scientists-demonstrate-quantum-radar-prototype/
  record:
  - id: '9001'
    relation: later_version
    status: public
scopus_import: '1'
status: public
title: Microwave quantum illumination using a digital receiver
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2020'
...
---
_id: '8986'
abstract:
- lang: eng
  text: 'Flowering plants display the highest diversity among plant species and have
    notably shaped terrestrial landscapes. Nonetheless, the evolutionary origin of
    their unprecedented morphological complexity remains largely an enigma. Here,
    we show that the coevolution of cis-regulatory and coding regions of PIN-FORMED
    (PIN) auxin transporters confined their expression to certain cell types and directed
    their subcellular localization to particular cell sides, which together enabled
    dynamic auxin gradients across tissues critical to the complex architecture of
    flowering plants. Extensive intraspecies and interspecies genetic complementation
    experiments with PINs from green alga up to flowering plant lineages showed that
    PIN genes underwent three subsequent, critical evolutionary innovations and thus
    acquired a triple function to regulate the development of three essential components
    of the flowering plant Arabidopsis: shoot/root, inflorescence, and floral organ.
    Our work highlights the critical role of functional innovations within the PIN
    gene family as essential prerequisites for the origin of flowering plants.'
acknowledgement: 'We thank C.Löhne (Botanic Gardens, University of Bonn) for providing
  us with A. trichopoda. We would like to thank T.Han, A.Mally (IST, Austria), and
  C.Hartinger (University of Oxford) for constructive comment and careful reading.
  Funding: The research leading to these results has received funding from the European
  Union’s Horizon 2020 Research and Innovation Programme (ERC grant agreement number
  742985), Austrian Science Fund (FWF, grant number I 3630-B25), DOC Fellowship of
  the Austrian Academy of Sciences, and IST Fellow program. '
article_number: eabc8895
article_processing_charge: No
article_type: original
author:
- first_name: Yuzhou
  full_name: Zhang, Yuzhou
  id: 3B6137F2-F248-11E8-B48F-1D18A9856A87
  last_name: Zhang
  orcid: 0000-0003-2627-6956
- first_name: Lesia
  full_name: Rodriguez Solovey, Lesia
  id: 3922B506-F248-11E8-B48F-1D18A9856A87
  last_name: Rodriguez Solovey
  orcid: 0000-0002-7244-7237
- first_name: Lanxin
  full_name: Li, Lanxin
  id: 367EF8FA-F248-11E8-B48F-1D18A9856A87
  last_name: Li
  orcid: 0000-0002-5607-272X
- first_name: Xixi
  full_name: Zhang, Xixi
  id: 61A66458-47E9-11EA-85BA-8AEAAF14E49A
  last_name: Zhang
  orcid: 0000-0001-7048-4627
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
citation:
  ama: Zhang Y, Rodriguez Solovey L, Li L, Zhang X, Friml J. Functional innovations
    of PIN auxin transporters mark crucial evolutionary transitions during rise of
    flowering plants. <i>Science Advances</i>. 2020;6(50). doi:<a href="https://doi.org/10.1126/sciadv.abc8895">10.1126/sciadv.abc8895</a>
  apa: Zhang, Y., Rodriguez Solovey, L., Li, L., Zhang, X., &#38; Friml, J. (2020).
    Functional innovations of PIN auxin transporters mark crucial evolutionary transitions
    during rise of flowering plants. <i>Science Advances</i>. AAAS. <a href="https://doi.org/10.1126/sciadv.abc8895">https://doi.org/10.1126/sciadv.abc8895</a>
  chicago: Zhang, Yuzhou, Lesia Rodriguez Solovey, Lanxin Li, Xixi Zhang, and Jiří
    Friml. “Functional Innovations of PIN Auxin Transporters Mark Crucial Evolutionary
    Transitions during Rise of Flowering Plants.” <i>Science Advances</i>. AAAS, 2020.
    <a href="https://doi.org/10.1126/sciadv.abc8895">https://doi.org/10.1126/sciadv.abc8895</a>.
  ieee: Y. Zhang, L. Rodriguez Solovey, L. Li, X. Zhang, and J. Friml, “Functional
    innovations of PIN auxin transporters mark crucial evolutionary transitions during
    rise of flowering plants,” <i>Science Advances</i>, vol. 6, no. 50. AAAS, 2020.
  ista: Zhang Y, Rodriguez Solovey L, Li L, Zhang X, Friml J. 2020. Functional innovations
    of PIN auxin transporters mark crucial evolutionary transitions during rise of
    flowering plants. Science Advances. 6(50), eabc8895.
  mla: Zhang, Yuzhou, et al. “Functional Innovations of PIN Auxin Transporters Mark
    Crucial Evolutionary Transitions during Rise of Flowering Plants.” <i>Science
    Advances</i>, vol. 6, no. 50, eabc8895, AAAS, 2020, doi:<a href="https://doi.org/10.1126/sciadv.abc8895">10.1126/sciadv.abc8895</a>.
  short: Y. Zhang, L. Rodriguez Solovey, L. Li, X. Zhang, J. Friml, Science Advances
    6 (2020).
corr_author: '1'
date_created: 2021-01-03T23:01:23Z
date_published: 2020-12-11T00:00:00Z
date_updated: 2026-04-29T22:31:06Z
day: '11'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1126/sciadv.abc8895
ec_funded: 1
external_id:
  isi:
  - '000599903600014'
  pmid:
  - '33310852'
file:
- access_level: open_access
  checksum: 5ac2500b191c08ef6dab5327f40ff663
  content_type: application/pdf
  creator: dernst
  date_created: 2021-01-07T12:44:33Z
  date_updated: 2021-01-07T12:44:33Z
  file_id: '8994'
  file_name: 2020_ScienceAdvances_Zhang.pdf
  file_size: 10578145
  relation: main_file
  success: 1
file_date_updated: 2021-01-07T12:44:33Z
has_accepted_license: '1'
intvolume: '         6'
isi: 1
issue: '50'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '742985'
  name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 26538374-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I03630
  name: Molecular mechanisms of endocytic cargo recognition in plants
- _id: 26B4D67E-B435-11E9-9278-68D0E5697425
  grant_number: '25351'
  name: 'A Case Study of Plant Growth Regulation: Molecular Mechanism of Auxin-mediated
    Rapid Growth Inhibition in Arabidopsis Root'
publication: Science Advances
publication_identifier:
  eissn:
  - 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
related_material:
  record:
  - id: '10083'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Functional innovations of PIN auxin transporters mark crucial evolutionary
  transitions during rise of flowering plants
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 6
year: '2020'
...
---
_id: '6919'
article_number: eaaw6490
article_processing_charge: No
author:
- first_name: Chao
  full_name: Qi, Chao
  last_name: Qi
- first_name: Giulio Di
  full_name: Minin, Giulio Di
  last_name: Minin
- first_name: Irene
  full_name: Vercellino, Irene
  id: 3ED6AF16-F248-11E8-B48F-1D18A9856A87
  last_name: Vercellino
  orcid: 0000-0001-5618-3449
- first_name: Anton
  full_name: Wutz, Anton
  last_name: Wutz
- first_name: Volodymyr M.
  full_name: Korkhov, Volodymyr M.
  last_name: Korkhov
citation:
  ama: Qi C, Minin GD, Vercellino I, Wutz A, Korkhov VM. Structural basis of sterol
    recognition by human hedgehog receptor PTCH1. <i>Science Advances</i>. 2019;5(9).
    doi:<a href="https://doi.org/10.1126/sciadv.aaw6490">10.1126/sciadv.aaw6490</a>
  apa: Qi, C., Minin, G. D., Vercellino, I., Wutz, A., &#38; Korkhov, V. M. (2019).
    Structural basis of sterol recognition by human hedgehog receptor PTCH1. <i>Science
    Advances</i>. American Association for the Advancement of Science. <a href="https://doi.org/10.1126/sciadv.aaw6490">https://doi.org/10.1126/sciadv.aaw6490</a>
  chicago: Qi, Chao, Giulio Di Minin, Irene Vercellino, Anton Wutz, and Volodymyr
    M. Korkhov. “Structural Basis of Sterol Recognition by Human Hedgehog Receptor
    PTCH1.” <i>Science Advances</i>. American Association for the Advancement of Science,
    2019. <a href="https://doi.org/10.1126/sciadv.aaw6490">https://doi.org/10.1126/sciadv.aaw6490</a>.
  ieee: C. Qi, G. D. Minin, I. Vercellino, A. Wutz, and V. M. Korkhov, “Structural
    basis of sterol recognition by human hedgehog receptor PTCH1,” <i>Science Advances</i>,
    vol. 5, no. 9. American Association for the Advancement of Science, 2019.
  ista: Qi C, Minin GD, Vercellino I, Wutz A, Korkhov VM. 2019. Structural basis of
    sterol recognition by human hedgehog receptor PTCH1. Science Advances. 5(9), eaaw6490.
  mla: Qi, Chao, et al. “Structural Basis of Sterol Recognition by Human Hedgehog
    Receptor PTCH1.” <i>Science Advances</i>, vol. 5, no. 9, eaaw6490, American Association
    for the Advancement of Science, 2019, doi:<a href="https://doi.org/10.1126/sciadv.aaw6490">10.1126/sciadv.aaw6490</a>.
  short: C. Qi, G.D. Minin, I. Vercellino, A. Wutz, V.M. Korkhov, Science Advances
    5 (2019).
date_created: 2019-09-29T22:00:45Z
date_published: 2019-09-18T00:00:00Z
date_updated: 2026-04-03T09:43:31Z
day: '18'
ddc:
- '570'
department:
- _id: LeSa
doi: 10.1126/sciadv.aaw6490
external_id:
  isi:
  - '000491128800062'
file:
- access_level: open_access
  checksum: b2256c9117655bc15f621ba0babf219f
  content_type: application/pdf
  creator: kschuh
  date_created: 2019-10-02T11:13:54Z
  date_updated: 2020-07-14T12:47:44Z
  file_id: '6928'
  file_name: 2019_AAAS_Qi.pdf
  file_size: 1236101
  relation: main_file
file_date_updated: 2020-07-14T12:47:44Z
has_accepted_license: '1'
intvolume: '         5'
isi: 1
issue: '9'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
publication: Science Advances
publication_identifier:
  eissn:
  - 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Structural basis of sterol recognition by human hedgehog receptor PTCH1
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 5
year: '2019'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '17949'
abstract:
- lang: eng
  text: Single-molecule electronic devices provide researchers with an unprecedented
    ability to relate novel physical phenomena to molecular chemical structures. Typically,
    conjugated aromatic molecular backbones are relied upon to create electronic devices,
    where the aromaticity of the building blocks is used to enhance conductivity.
    We capitalize on the classical physical organic chemistry concept of Hückel antiaromaticity
    by demonstrating a single-molecule switch that exhibits low conductance in the
    neutral state and, upon electrochemical oxidation, reversibly switches to an antiaromatic
    high-conducting structure. We form single-molecule devices using the scanning
    tunneling microscope–based break-junction technique and observe an on/off ratio
    of ~70 for a thiophenylidene derivative that switches to an antiaromatic state
    with 6-4-6-π electrons. Through supporting nuclear magnetic resonance measurements,
    we show that the doubly oxidized core has antiaromatic character and we use density
    functional theory calculations to rationalize the origin of the high-conductance
    state for the oxidized single-molecule junction. Together, our work demonstrates
    how the concept of antiaromaticity can be exploited to create single-molecule
    devices that are highly conducting.
article_number: aao2615
article_processing_charge: Yes
article_type: original
author:
- first_name: Xiaodong
  full_name: Yin, Xiaodong
  last_name: Yin
- first_name: Yaping
  full_name: Zang, Yaping
  last_name: Zang
- first_name: Liangliang
  full_name: Zhu, Liangliang
  last_name: Zhu
- first_name: Jonathan Z.
  full_name: Low, Jonathan Z.
  last_name: Low
- first_name: Zhen-Fei
  full_name: Liu, Zhen-Fei
  last_name: Liu
- first_name: Jing
  full_name: Cui, Jing
  last_name: Cui
- first_name: Jeffrey B.
  full_name: Neaton, Jeffrey B.
  last_name: Neaton
- first_name: Latha
  full_name: Venkataraman, Latha
  id: 9ebb78a5-cc0d-11ee-8322-fae086a32caf
  last_name: Venkataraman
  orcid: 0000-0002-6957-6089
- first_name: Luis M.
  full_name: Campos, Luis M.
  last_name: Campos
citation:
  ama: Yin X, Zang Y, Zhu L, et al. A reversible single-molecule switch based on activated
    antiaromaticity. <i>Science Advances</i>. 2017;3(10). doi:<a href="https://doi.org/10.1126/sciadv.aao2615">10.1126/sciadv.aao2615</a>
  apa: Yin, X., Zang, Y., Zhu, L., Low, J. Z., Liu, Z.-F., Cui, J., … Campos, L. M.
    (2017). A reversible single-molecule switch based on activated antiaromaticity.
    <i>Science Advances</i>. American Association for the Advancement of Science.
    <a href="https://doi.org/10.1126/sciadv.aao2615">https://doi.org/10.1126/sciadv.aao2615</a>
  chicago: Yin, Xiaodong, Yaping Zang, Liangliang Zhu, Jonathan Z. Low, Zhen-Fei Liu,
    Jing Cui, Jeffrey B. Neaton, Latha Venkataraman, and Luis M. Campos. “A Reversible
    Single-Molecule Switch Based on Activated Antiaromaticity.” <i>Science Advances</i>.
    American Association for the Advancement of Science, 2017. <a href="https://doi.org/10.1126/sciadv.aao2615">https://doi.org/10.1126/sciadv.aao2615</a>.
  ieee: X. Yin <i>et al.</i>, “A reversible single-molecule switch based on activated
    antiaromaticity,” <i>Science Advances</i>, vol. 3, no. 10. American Association
    for the Advancement of Science, 2017.
  ista: Yin X, Zang Y, Zhu L, Low JZ, Liu Z-F, Cui J, Neaton JB, Venkataraman L, Campos
    LM. 2017. A reversible single-molecule switch based on activated antiaromaticity.
    Science Advances. 3(10), aao2615.
  mla: Yin, Xiaodong, et al. “A Reversible Single-Molecule Switch Based on Activated
    Antiaromaticity.” <i>Science Advances</i>, vol. 3, no. 10, aao2615, American Association
    for the Advancement of Science, 2017, doi:<a href="https://doi.org/10.1126/sciadv.aao2615">10.1126/sciadv.aao2615</a>.
  short: X. Yin, Y. Zang, L. Zhu, J.Z. Low, Z.-F. Liu, J. Cui, J.B. Neaton, L. Venkataraman,
    L.M. Campos, Science Advances 3 (2017).
date_created: 2024-09-09T09:12:08Z
date_published: 2017-10-01T00:00:00Z
date_updated: 2024-12-18T07:54:32Z
day: '01'
doi: 10.1126/sciadv.aao2615
extern: '1'
intvolume: '         3'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1126/sciadv.aao2615
month: '10'
oa: 1
oa_version: Published Version
publication: Science Advances
publication_identifier:
  eissn:
  - 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
related_material:
  link:
  - relation: erratum
    url: https://doi.org/10.1126/sciadv.abq0115
scopus_import: '1'
status: public
title: A reversible single-molecule switch based on activated antiaromaticity
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2017'
...
